CN105853458A - Vitamin E selenium and preparation method thereof - Google Patents
Vitamin E selenium and preparation method thereof Download PDFInfo
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- CN105853458A CN105853458A CN201610260507.XA CN201610260507A CN105853458A CN 105853458 A CN105853458 A CN 105853458A CN 201610260507 A CN201610260507 A CN 201610260507A CN 105853458 A CN105853458 A CN 105853458A
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- China
- Prior art keywords
- vitamin
- selenium
- preparation
- selenocarrageenan
- licopersicin
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- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 title claims abstract description 87
- 229930003427 Vitamin E Natural products 0.000 title claims abstract description 43
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 title claims abstract description 43
- 229940046009 vitamin E Drugs 0.000 title claims abstract description 43
- 235000019165 vitamin E Nutrition 0.000 title claims abstract description 43
- 239000011709 vitamin E Substances 0.000 title claims abstract description 43
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 title claims abstract description 40
- 239000011669 selenium Substances 0.000 title claims abstract description 40
- 229910052711 selenium Inorganic materials 0.000 title claims abstract description 40
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 239000002904 solvent Substances 0.000 claims abstract description 10
- 229940113118 carrageenan Drugs 0.000 claims abstract description 6
- 235000010418 carrageenan Nutrition 0.000 claims abstract description 6
- 239000000679 carrageenan Substances 0.000 claims abstract description 6
- 229920001525 carrageenan Polymers 0.000 claims abstract description 6
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims abstract description 6
- 229940091258 selenium supplement Drugs 0.000 claims description 35
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 18
- 238000001035 drying Methods 0.000 claims description 10
- 239000012047 saturated solution Substances 0.000 claims description 10
- 229960000935 dehydrated alcohol Drugs 0.000 claims description 8
- 239000000243 solution Substances 0.000 claims description 6
- 238000006243 chemical reaction Methods 0.000 claims description 5
- BVTBRVFYZUCAKH-UHFFFAOYSA-L disodium selenite Chemical compound [Na+].[Na+].[O-][Se]([O-])=O BVTBRVFYZUCAKH-UHFFFAOYSA-L 0.000 claims description 5
- 229960004756 ethanol Drugs 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 229960001471 sodium selenite Drugs 0.000 claims description 5
- 235000015921 sodium selenite Nutrition 0.000 claims description 5
- 239000011781 sodium selenite Substances 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- PMYDPQQPEAYXKD-UHFFFAOYSA-N 3-hydroxy-n-naphthalen-2-ylnaphthalene-2-carboxamide Chemical compound C1=CC=CC2=CC(NC(=O)C3=CC4=CC=CC=C4C=C3O)=CC=C21 PMYDPQQPEAYXKD-UHFFFAOYSA-N 0.000 claims description 3
- MCAHWIHFGHIESP-UHFFFAOYSA-N selenous acid Chemical compound O[Se](O)=O MCAHWIHFGHIESP-UHFFFAOYSA-N 0.000 claims description 3
- 229960001881 sodium selenate Drugs 0.000 claims description 3
- 235000018716 sodium selenate Nutrition 0.000 claims description 3
- 239000011655 sodium selenate Substances 0.000 claims description 3
- 230000004071 biological effect Effects 0.000 abstract description 7
- 230000003064 anti-oxidating effect Effects 0.000 abstract description 4
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- 238000010521 absorption reaction Methods 0.000 abstract description 2
- 238000011031 large-scale manufacturing process Methods 0.000 abstract description 2
- 150000002632 lipids Chemical class 0.000 abstract description 2
- 230000002349 favourable effect Effects 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
- REJLGAUYTKNVJM-SGXCCWNXSA-N tomatine Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@H]1[C@@H](CO)O[C@H]([C@@H]([C@H]1O)O)O[C@@H]1C[C@@H]2CC[C@H]3[C@@H]4C[C@H]5[C@@H]([C@]4(CC[C@@H]3[C@@]2(C)CC1)C)[C@@H]([C@@]1(NC[C@@H](C)CC1)O5)C)[C@@H]1OC[C@@H](O)[C@H](O)[C@H]1O REJLGAUYTKNVJM-SGXCCWNXSA-N 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 description 4
- 230000004224 protection Effects 0.000 description 4
- 210000000170 cell membrane Anatomy 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 238000002835 absorbance Methods 0.000 description 2
- 230000001093 anti-cancer Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 210000004153 islets of langerhan Anatomy 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000001850 reproductive effect Effects 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 206010000234 Abortion spontaneous Diseases 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 208000002177 Cataract Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 208000019926 Keshan disease Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- -1 Polyoxyethylene Polymers 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 229910052785 arsenic Inorganic materials 0.000 description 1
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 229910052793 cadmium Inorganic materials 0.000 description 1
- BDOSMKKIYDKNTQ-UHFFFAOYSA-N cadmium atom Chemical compound [Cd] BDOSMKKIYDKNTQ-UHFFFAOYSA-N 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 231100000315 carcinogenic Toxicity 0.000 description 1
- 230000005961 cardioprotection Effects 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 210000003855 cell nucleus Anatomy 0.000 description 1
- 210000000349 chromosome Anatomy 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 1
- 235000003969 glutathione Nutrition 0.000 description 1
- 229960003180 glutathione Drugs 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 230000026109 gonad development Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 230000002519 immonomodulatory effect Effects 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 208000015994 miscarriage Diseases 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 238000011027 product recovery Methods 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 208000000995 spontaneous abortion Diseases 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to vitamin E selenium and a preparation method thereof. The vitamin E selenium comprises the following components in percentage by weight: 0.01% to 0.08% of selenium carrageenan, 8% to 12% of vitamin E, 5% to 8% of tomatin, and the balance of solvent. The invention also discloses a preparation method of the vitamin E selenium. The vitamin E selenium and the preparation method have the advantages that the biological activity is high, the lipid solubility is high, the oral absorption is favorable, the absorbing rate is high, the property is stable, the convenience in use is realized, and the selenium element is effectively supplemented; the biological activity is high, the deformation of cytomembrane is effectively prevented, and the anti-oxidizing property is strong; the preparation method is simple and convenient, the production cycle is short, the recovery rate of product is high, the zero emission of three wastes is realized in the production process, and the preparation method is suitable for large-scale production.
Description
Technical field
The present invention relates to health product technology field, particularly relate to a kind of vitamin E selenium and preparation method thereof.
Background technology
Selenium is human body and the required trace element of animal, and it is the constituent of erythrocyte glutathion peroxidase, and its Main Function is the synthesis participating in enzyme, and the structure of protection cell membrane exempts from over oxidation and interference with function.Have anticancer, anti-cancer, cardioprotection, prevent and treat cataract, prevent and treat the functions such as Keshan disease, Kaschin-Beck disease and slow down aging, the most also to some heavy metal elements (as lead, arsenic, cadmium, hydrargyrum, etc.) have Detoxication.
Vitamin E (Vitamin E) is a kind of fatsoluble vitamin, also known as tocopherol, is one of topmost antioxidant.There is anti-oxidation function, required for animal normal growth and fertility.Vitamin E can the unsaturated fatty acid of protection structure biomembrane lipoids from oxidation; the integrity of protection lipid film; participate in maintaining animal normal reproductive function; promote gonad development, facilitate and become pregnant and prevent miscarriage, and capillary of skin resistance can be strengthened; and maintain normal permeability; improve humans and animals blood circulation, there is adjustment reproductive function, the anti-ageing effect of waiting for a long time.
Selenium and vitamin E all can enhancing human body immunity ability, both merge use, and immunologic function is more notable.Selenium can strengthen the antioxidation of vitamin E, the existence of vitamin E, can reduce the consumption of selenium, and both share and can play mutual synergism.
At present, the inorganic selenium that the vitamin E selenium on market generally utilizes, inorganic selenium directly acts on, with vitamin E, the vitamin E selenium obtained, and usual biological activity is relatively low, is difficult to absorb, and unstable properties, bioavailability is the highest.
Chinese patent 201210544609.6 discloses a kind of sodium selenite vitamin E injection, and it includes the following component in 100ml: vitamin E 5g, sodium selenite 0.1g, solubilizing agent 7.5g-10.0g, solvent 0.5-5ml, surplus is water for injection；Described solubilizing agent is Tween 80 or Polyoxyethylene castor oil EL-40；Described solvent is dehydrated alcohol.This invention gained can the injection biological activity of simultaneously vitimin supplement E and selenium low, be difficult to absorb, utilization rate is relatively low.
Summary of the invention
The technical problem to be solved is, overcomes the drawbacks described above of existing existence, it is provided that a kind of biological activity vitamin E selenium high, that beneficially absorb and preparation method thereof.
The technical solution adopted for the present invention to solve the technical problems is: a kind of vitamin E selenium, the weight percent content of each component is: selenocarrageenan 0.01～0.08%(preferably 0.04%), vitamin E 8～12%(preferably 10%), licopersicin 5～8%(preferably 6%), surplus is solvent.
Further, described solvent is dehydrated alcohol.
Further, described selenocarrageenan is prepared by enzymolysis selenylation reaction by carrageenan and inorganic selenium.
Further, described inorganic selenium is for being sodium selenite, Monohydrated selenium dioxide or sodium selenate.
Its preparation method, comprises the following steps:
(1) selenocarrageenan and licopersicin are dissolved in dehydrated alcohol, obtain saturated solution；
(2) being mixed with vitamin E by the saturated solution that step (1) prepares, stir 1h, room temperature shading stands 24h；
(3) reduce pressure in Rotary Evaporators cold drying by the mixture that step (2) prepares, baking temperature is 30-50 DEG C, and drying time is 3-5h, reclaims ethanol, obtains one oily solution；
I.e. vitamin E selenium.
Compared with prior art, the invention have the advantages that biological activity is high, fat-soluble height, beneficially oral absorption, absorbance is high, and stable performance is easy to use, can the synergistic function of effectively Selenium Supplement element, licopersicin and selenocarrageenan；Biological activity is high, can effectively prevent cell membrane degeneration, have strong anti-oxidation; the mutual synergism of licopersicin, selenocarrageenan and vitamin E; increasing the excretion of selenium, reduce the toxicity of selenium, coordinating protection cell membrane, nucleus and chromosome be not by carcinogenic injury；Product has immunomodulating, face nourishing antidebilitation, speckle dispelling, prophylaxis of cancer and cardiovascular disease, reduces the damage of radical pair β islet cells, promotes the functions such as β islet cells reparation, can also can be as some food or the additive of feedstuff as health food；Preparation method is easy, with short production cycle, and product recovery rate is high, and production process realizes " three wastes " zero-emission, is suitable to large-scale production.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further described.
Embodiment 1
The present embodiment comprises the following steps:
(1) selenocarrageenan and 7% licopersicin that weight percent content is 0.02% are dissolved in dehydrated alcohol, obtain saturated solution；
(2) saturated solution step (1) prepared and the mixing of 9% vitamin E, stir 1h, and room temperature shading stands 24h；
(3) reduce pressure in Rotary Evaporators cold drying by the mixture that step (2) prepares, baking temperature is 40 DEG C, and drying time is 4h, reclaims ethanol, obtains one oily solution；
I.e. vitamin E selenium.
In the present embodiment, selenocarrageenan is prepared by enzymolysis selenylation reaction by carrageenan and Monohydrated selenium dioxide.
Embodiment 2
The present embodiment comprises the following steps:
(1) selenocarrageenan and 6% licopersicin that weight percent content is 0.05% are dissolved in dehydrated alcohol, obtain saturated solution；
(2) saturated solution step (1) prepared and the mixing of 11% vitamin E, stir 1h, and room temperature shading stands 24h；
(3) reduce pressure in Rotary Evaporators cold drying by the mixture that step (2) prepares, baking temperature is 40 DEG C, and drying time is 4h, reclaims ethanol, obtains one oily solution；
I.e. vitamin E selenium.
In the present embodiment, selenocarrageenan is prepared by enzymolysis selenylation reaction by carrageenan and sodium selenate.
Embodiment 3
The present embodiment comprises the following steps:
(1) selenocarrageenan and 6% licopersicin that weight percent content is 0.07% are dissolved in dehydrated alcohol, obtain saturated solution；
(2) saturated solution step (1) prepared and the mixing of 10% vitamin E, stir 1h, and room temperature shading stands 24h；
(3) reduce pressure in Rotary Evaporators cold drying by the mixture that step (2) prepares, baking temperature is 40 DEG C, and drying time is 4h, reclaims ethanol, obtains one oily solution；
I.e. vitamin E selenium.
In the present embodiment, selenocarrageenan is prepared by enzymolysis selenylation reaction by carrageenan and sodium selenite.
Performance test:
Above-mentioned gained vitamin E selenium is dissolved in water, according to country selenium supplement standard adult μ g/d every day 200, is converted to mouse dose by body surface area, toxic reaction does not occurs to mouse gavaging according to 100 times.
After being taken to human body by vitamin E selenium, mouthfeel is good, and absorbance is good, can effectively vitimin supplement E and selenium element.
Claims (6)
1. a vitamin E selenium, it is characterised in that the weight percent content of each component is: selenocarrageenan 0.01～0.08%, vitamin E 8～12%, licopersicin 5～8%, surplus is solvent.
Vitamin E selenium the most according to claim 1, it is characterised in that selenocarrageenan 0.04%, vitamin E 10%, licopersicin 6%, surplus is solvent.
Vitamin E selenium the most according to claim 1 and 2, it is characterised in that described solvent is dehydrated alcohol.
Vitamin E selenium the most according to claim 3, it is characterised in that described selenocarrageenan is prepared by enzymolysis selenylation reaction by carrageenan and inorganic selenium.
Vitamin E selenium the most according to claim 4, it is characterised in that described inorganic selenium is for being sodium selenite, Monohydrated selenium dioxide or sodium selenate.
The preparation method of vitamin E selenium the most according to claim 1, it is characterised in that comprise the following steps:
(1) selenocarrageenan and licopersicin are dissolved in dehydrated alcohol, obtain saturated solution；
(2) being mixed with vitamin E by the saturated solution that step (1) prepares, stir 1h, room temperature shading stands 24h；
(3) reduce pressure in Rotary Evaporators cold drying by the mixture that step (2) prepares, baking temperature is 30-50 DEG C, and drying time is 3-5h, reclaims ethanol, obtains one oily solution；
I.e. vitamin E selenium.
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| CN201610260507.XA CN105853458A (en) | 2016-04-25 | 2016-04-25 | Vitamin E selenium and preparation method thereof |
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| CN201610260507.XA CN105853458A (en) | 2016-04-25 | 2016-04-25 | Vitamin E selenium and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106265891A (en) * | 2016-08-30 | 2017-01-04 | 芜湖华海生物工程有限公司 | A kind of vitamin E capsule and preparation method thereof |
| CN112220046A (en) * | 2020-10-28 | 2021-01-15 | 青岛鹏洋生物工程有限公司 | Compound nutrition enhancer containing seleno-carrageenan and preparation method thereof |
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| CN104415053A (en) * | 2013-08-23 | 2015-03-18 | 石药集团中奇制药技术（石家庄）有限公司 | Anti-oxidation and anti-aging composition |
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2016
- 2016-04-25 CN CN201610260507.XA patent/CN105853458A/en active Pending
Patent Citations (4)
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|---|---|---|---|---|
| CN1757409A (en) * | 2005-09-20 | 2006-04-12 | 上海泰运科技有限公司 | Recipe of Wanshou capsule, and health-care function |
| CN102174119A (en) * | 2011-03-04 | 2011-09-07 | 无锡健特药业有限公司 | Selenized carrageenan and preparation method thereof |
| CN102824371A (en) * | 2012-08-23 | 2012-12-19 | 石药集团中奇制药技术（石家庄）有限公司 | Propolis-lycopene composition and preparation method thereof |
| CN104415053A (en) * | 2013-08-23 | 2015-03-18 | 石药集团中奇制药技术（石家庄）有限公司 | Anti-oxidation and anti-aging composition |
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| CN106265891A (en) * | 2016-08-30 | 2017-01-04 | 芜湖华海生物工程有限公司 | A kind of vitamin E capsule and preparation method thereof |
| CN112220046A (en) * | 2020-10-28 | 2021-01-15 | 青岛鹏洋生物工程有限公司 | Compound nutrition enhancer containing seleno-carrageenan and preparation method thereof |
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