CN105853422A - 联合使用拉喹莫德和富马酸二甲酯治疗多发性硬化症的方法 - Google Patents
联合使用拉喹莫德和富马酸二甲酯治疗多发性硬化症的方法 Download PDFInfo
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- CN105853422A CN105853422A CN201610252021.1A CN201610252021A CN105853422A CN 105853422 A CN105853422 A CN 105853422A CN 201610252021 A CN201610252021 A CN 201610252021A CN 105853422 A CN105853422 A CN 105853422A
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- laquinimod
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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Landscapes
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261616337P | 2012-03-27 | 2012-03-27 | |
| US61/616,337 | 2012-03-27 | ||
| US13/800,047 | 2013-03-13 | ||
| US13/800,047 US20130259856A1 (en) | 2012-03-27 | 2013-03-13 | Treatment of multiple sclerosis with combination of laquinimod and dimethyl fumarate |
| CN201380016933.3A CN104470520A (zh) | 2012-03-27 | 2013-03-26 | 联合使用拉喹莫德和富马酸二甲酯治疗多发性硬化症的方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380016933.3A Division CN104470520A (zh) | 2012-03-27 | 2013-03-26 | 联合使用拉喹莫德和富马酸二甲酯治疗多发性硬化症的方法 |
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| CN105853422A true CN105853422A (zh) | 2016-08-17 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380016933.3A Pending CN104470520A (zh) | 2012-03-27 | 2013-03-26 | 联合使用拉喹莫德和富马酸二甲酯治疗多发性硬化症的方法 |
| CN201610252021.1A Pending CN105853422A (zh) | 2012-03-27 | 2013-03-26 | 联合使用拉喹莫德和富马酸二甲酯治疗多发性硬化症的方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN201380016933.3A Pending CN104470520A (zh) | 2012-03-27 | 2013-03-26 | 联合使用拉喹莫德和富马酸二甲酯治疗多发性硬化症的方法 |
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| JP (2) | JP2015512406A (enExample) |
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| AR089862A1 (es) | 2012-02-03 | 2014-09-24 | Teva Pharma | USO DE LAQUINIMOD PARA EL TRATAMIENTO DE PACIENTES CON ENFERMEDAD DE CROHN EN QUIENES FRACASO UNA TERAPIA ANTI-FACTOR DE NECROSIS TUMORAL a (ANTI-TNFa) DE PRIMERA LINEA |
| EP2744498A4 (en) | 2012-02-16 | 2014-12-03 | Teva Pharma | N-ETHYL-N-PHENYL-1,2-DIHYDRO-4,5-DI-HYDROXY-1-METHYL-2-OXO-3-CHINOLINE CARBOXAMIDE AND THE PREPARATION AND USE THEREOF |
| TW201400117A (zh) | 2012-06-05 | 2014-01-01 | Teva Pharma | 使用拉喹莫德治療眼發炎疾病 |
| EP2692343A1 (en) * | 2012-08-03 | 2014-02-05 | Forward Pharma A/S | Combination therapy for treatment of multiple sclerosis |
| TW201410244A (zh) | 2012-08-13 | 2014-03-16 | Teva Pharma | 用於治療ｇａｂａ媒介之疾病之拉喹莫德（ｌａｑｕｉｎｉｍｏｄ） |
| AU2013305684B2 (en) | 2012-08-22 | 2016-11-24 | Xenoport, Inc. | Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof |
| JP2015527372A (ja) | 2012-08-22 | 2015-09-17 | ゼノポート，インコーポレイティド | 副作用を低減させるモノメチルフマレートおよびそのプロドラッグの投与方法 |
| HK1215210A1 (zh) | 2012-11-07 | 2016-08-19 | Teva Pharmaceutical Industries Ltd. | 拉喹莫德胺盐 |
| CA2901849A1 (en) | 2013-03-14 | 2014-09-25 | Teva Pharmaceutical Industries Ltd. | Crystals of laquinimod sodium and improved process for the manufacture thereof |
| WO2014160633A1 (en) | 2013-03-24 | 2014-10-02 | Xenoport, Inc. | Pharmaceutical compositions of dimethyl fumarate |
| WO2014197860A1 (en) | 2013-06-07 | 2014-12-11 | Xenoport, Inc. | Method of making monomethyl fumarate |
| US9421182B2 (en) | 2013-06-21 | 2016-08-23 | Xenoport, Inc. | Cocrystals of dimethyl fumarate |
| EP3041467A1 (en) | 2013-09-06 | 2016-07-13 | XenoPort, Inc. | Crystalline forms of (n,n-diethylcarbamoyl)methyl methyl (2e)but-2-ene-1,4-dioate, methods of synthesis and use |
| US9326947B1 (en) | 2014-02-28 | 2016-05-03 | Banner Life Sciences Llc | Controlled release fumarate esters |
| WO2015130998A1 (en) | 2014-02-28 | 2015-09-03 | Banner Life Sciences Llc | Controlled release enteric soft capsules of fumarate esters |
| US10098863B2 (en) | 2014-02-28 | 2018-10-16 | Banner Life Sciences Llc | Fumarate esters |
| US9636318B2 (en) | 2015-08-31 | 2017-05-02 | Banner Life Sciences Llc | Fumarate ester dosage forms |
| US9999672B2 (en) | 2014-03-24 | 2018-06-19 | Xenoport, Inc. | Pharmaceutical compositions of fumaric acid esters |
| SG11201608674UA (en) | 2014-04-29 | 2016-11-29 | Teva Pharma | Laquinimod for the treatment of relapsing-remitting multiple sclerosis (rrms) patients with a high disability status |
| MA41139A (fr) | 2014-12-11 | 2017-10-17 | Actelion Pharmaceuticals Ltd | Combinaison pharmaceutique comportant un agoniste sélectif du récepteur sip1 |
| UA122064C2 (uk) | 2014-12-11 | 2020-09-10 | Актеліон Фармасьютікалз Лтд | Схема дозування для селективного агоніста рецептора s1p1 |
| GB2540163A (en) * | 2015-07-07 | 2017-01-11 | Univ London Queen Mary | Combination therapy for treating multiple sclerosis |
| WO2017120355A1 (en) * | 2016-01-06 | 2017-07-13 | Teva Pharmaceutical Industries Ltd. | Dihydroquinolines and uses thereof |
| US11903918B2 (en) | 2020-01-10 | 2024-02-20 | Banner Life Sciences Llc | Fumarate ester dosage forms with enhanced gastrointestinal tolerability |
| US12483171B2 (en) | 2023-12-18 | 2025-11-25 | Abb Schweiz Ag | Plug and play solid state controller for high efficiency motors |
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2013
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- 2013-03-26 CA CA 2868259 patent/CA2868259A1/en not_active Abandoned
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- 2013-03-26 EA EA201491773A patent/EA201491773A1/ru unknown
- 2013-03-26 KR KR20147030064A patent/KR20150003765A/ko not_active Withdrawn
- 2013-03-26 JP JP2015503465A patent/JP2015512406A/ja not_active Withdrawn
- 2013-03-26 EP EP13768294.4A patent/EP2830623A4/en not_active Withdrawn
- 2013-03-26 AU AU2013239850A patent/AU2013239850A1/en not_active Abandoned
- 2013-03-26 CN CN201610252021.1A patent/CN105853422A/zh active Pending
- 2013-03-26 SG SG10201607976WA patent/SG10201607976WA/en unknown
- 2013-04-02 UY UY34720A patent/UY34720A/es not_active Application Discontinuation
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2014
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- 2014-10-23 ZA ZA2014/07722A patent/ZA201407722B/en unknown
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2015
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2017
- 2017-04-24 US US15/495,406 patent/US20170224675A1/en not_active Abandoned
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- 2017-07-27 US US15/662,165 patent/US20170319570A1/en not_active Abandoned
- 2017-11-03 US US15/803,017 patent/US20180050031A1/en not_active Abandoned
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Also Published As
| Publication number | Publication date |
|---|---|
| TW201343164A (zh) | 2013-11-01 |
| CN104470520A (zh) | 2015-03-25 |
| HK1205941A1 (en) | 2015-12-31 |
| SG11201405755QA (en) | 2014-10-30 |
| US20150119420A1 (en) | 2015-04-30 |
| AU2013239850A1 (en) | 2014-11-06 |
| AR090491A1 (es) | 2014-11-19 |
| US20170224675A1 (en) | 2017-08-10 |
| UY34720A (es) | 2013-10-31 |
| MX2014011616A (es) | 2014-10-17 |
| KR20150003765A (ko) | 2015-01-09 |
| SG10201607976WA (en) | 2016-11-29 |
| US20170319570A1 (en) | 2017-11-09 |
| IL234687A0 (en) | 2014-11-30 |
| US20180050031A1 (en) | 2018-02-22 |
| CA2868259A1 (en) | 2013-10-03 |
| US20130259856A1 (en) | 2013-10-03 |
| ZA201407722B (en) | 2016-06-29 |
| EA201491773A1 (ru) | 2015-02-27 |
| JP2015512406A (ja) | 2015-04-27 |
| JP2017200927A (ja) | 2017-11-09 |
| AU2018200065A1 (en) | 2018-02-01 |
| US20160000774A1 (en) | 2016-01-07 |
| EP2830623A1 (en) | 2015-02-04 |
| EP2830623A4 (en) | 2015-09-02 |
| WO2013148690A1 (en) | 2013-10-03 |
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