CN105852109A - Microemulsion for preventing cardiovascular diseases and preparation method thereof - Google Patents
Microemulsion for preventing cardiovascular diseases and preparation method thereof Download PDFInfo
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- CN105852109A CN105852109A CN201610264621.XA CN201610264621A CN105852109A CN 105852109 A CN105852109 A CN 105852109A CN 201610264621 A CN201610264621 A CN 201610264621A CN 105852109 A CN105852109 A CN 105852109A
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- vitamin
- microemulsion
- preservative
- surfactant
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- 208000024172 Cardiovascular disease Diseases 0.000 title claims abstract description 22
- 239000004530 micro-emulsion Substances 0.000 title claims abstract description 21
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 44
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 40
- 238000003756 stirring Methods 0.000 claims abstract description 28
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 22
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 22
- 239000004094 surface-active agent Substances 0.000 claims abstract description 22
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 22
- 229940046009 vitamin E Drugs 0.000 claims abstract description 22
- 239000011709 vitamin E Substances 0.000 claims abstract description 22
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 20
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 20
- 239000010495 camellia oil Substances 0.000 claims abstract description 20
- 239000004064 cosurfactant Substances 0.000 claims abstract description 20
- 239000003755 preservative agent Substances 0.000 claims abstract description 20
- 230000002335 preservative effect Effects 0.000 claims abstract description 20
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 20
- 239000011718 vitamin C Substances 0.000 claims abstract description 20
- 239000004376 Sucralose Substances 0.000 claims abstract description 18
- 235000019408 sucralose Nutrition 0.000 claims abstract description 18
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims abstract description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims abstract description 14
- 229920000053 polysorbate 80 Polymers 0.000 claims abstract description 14
- -1 phytosterol ester Substances 0.000 claims abstract description 10
- 239000007762 w/o emulsion Substances 0.000 claims abstract description 8
- 238000002156 mixing Methods 0.000 claims abstract description 5
- 239000000243 solution Substances 0.000 claims description 35
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 24
- 150000002148 esters Chemical class 0.000 claims description 19
- 235000002378 plant sterols Nutrition 0.000 claims description 19
- 230000002378 acidificating effect Effects 0.000 claims description 16
- 239000000796 flavoring agent Substances 0.000 claims description 16
- 235000013355 food flavoring agent Nutrition 0.000 claims description 16
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 15
- 229930195729 fatty acid Natural products 0.000 claims description 15
- 239000000194 fatty acid Substances 0.000 claims description 15
- 230000002265 prevention Effects 0.000 claims description 14
- 239000003795 chemical substances by application Substances 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 9
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 8
- 229920001030 Polyethylene Glycol 4000 Polymers 0.000 claims description 8
- 239000007864 aqueous solution Substances 0.000 claims description 8
- 230000000694 effects Effects 0.000 claims description 8
- 150000004665 fatty acids Chemical class 0.000 claims description 8
- 239000002994 raw material Substances 0.000 claims description 8
- 238000013019 agitation Methods 0.000 claims description 7
- 235000010199 sorbic acid Nutrition 0.000 claims description 7
- 229940075582 sorbic acid Drugs 0.000 claims description 7
- 239000004334 sorbic acid Substances 0.000 claims description 7
- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 claims description 6
- PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 claims description 6
- 229930006000 Sucrose Natural products 0.000 claims description 6
- 239000005720 sucrose Substances 0.000 claims description 6
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 claims description 5
- 230000003213 activating effect Effects 0.000 claims description 5
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 4
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 3
- 230000001105 regulatory effect Effects 0.000 claims description 3
- WSWCOQWTEOXDQX-MQQKCMAXSA-N sorbic acid group Chemical group C(\C=C\C=C\C)(=O)O WSWCOQWTEOXDQX-MQQKCMAXSA-N 0.000 claims description 3
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract description 18
- 235000012000 cholesterol Nutrition 0.000 abstract description 8
- 235000013305 food Nutrition 0.000 abstract description 8
- 239000008280 blood Substances 0.000 abstract description 7
- 210000004369 blood Anatomy 0.000 abstract description 7
- 239000012153 distilled water Substances 0.000 abstract description 5
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 abstract description 3
- 208000007536 Thrombosis Diseases 0.000 abstract description 3
- 210000001367 artery Anatomy 0.000 abstract description 3
- 239000003613 bile acid Substances 0.000 abstract description 3
- 230000015572 biosynthetic process Effects 0.000 abstract description 3
- 210000004204 blood vessel Anatomy 0.000 abstract description 3
- 239000000839 emulsion Substances 0.000 abstract description 2
- 239000007788 liquid Substances 0.000 abstract 4
- 229940075999 phytosterol ester Drugs 0.000 abstract 2
- 206010003210 Arteriosclerosis Diseases 0.000 abstract 1
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 5
- LRFDUPNLCDXZOE-UHFFFAOYSA-N camellianin b Chemical compound OC1C(O)C(O)C(C)OC1OC1C(O)C(O)C(OC=2C=3C(=O)C=C(OC=3C=C(O)C=2)C=2C=CC(O)=CC=2)OC1CO LRFDUPNLCDXZOE-UHFFFAOYSA-N 0.000 description 4
- 208000026106 cerebrovascular disease Diseases 0.000 description 4
- 230000002526 effect on cardiovascular system Effects 0.000 description 4
- 230000036541 health Effects 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- 206010020772 Hypertension Diseases 0.000 description 3
- 230000003078 antioxidant effect Effects 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 2
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 2
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 2
- 201000001320 Atherosclerosis Diseases 0.000 description 2
- 239000005642 Oleic acid Substances 0.000 description 2
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 2
- 241001122767 Theaceae Species 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 2
- 235000008390 olive oil Nutrition 0.000 description 2
- 239000004006 olive oil Substances 0.000 description 2
- 150000008442 polyphenolic compounds Chemical class 0.000 description 2
- 235000013824 polyphenols Nutrition 0.000 description 2
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 description 2
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- 108010023302 HDL Cholesterol Proteins 0.000 description 1
- 108010010234 HDL Lipoproteins Proteins 0.000 description 1
- 102000015779 HDL Lipoproteins Human genes 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 208000035150 Hypercholesterolemia Diseases 0.000 description 1
- 108010028554 LDL Cholesterol Proteins 0.000 description 1
- 108010007622 LDL Lipoproteins Proteins 0.000 description 1
- 102000007330 LDL Lipoproteins Human genes 0.000 description 1
- 108090001030 Lipoproteins Proteins 0.000 description 1
- 102000004895 Lipoproteins Human genes 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 244000173166 Pyrus ussuriensis Species 0.000 description 1
- 235000011572 Pyrus ussuriensis Nutrition 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000002155 anti-virotic effect Effects 0.000 description 1
- 235000008452 baby food Nutrition 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 230000003177 cardiotonic effect Effects 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 239000007957 coemulsifier Substances 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 201000005577 familial hyperlipidemia Diseases 0.000 description 1
- 239000005417 food ingredient Substances 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000021281 monounsaturated fatty acids Nutrition 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 235000010241 potassium sorbate Nutrition 0.000 description 1
- 239000004302 potassium sorbate Substances 0.000 description 1
- 229940069338 potassium sorbate Drugs 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 230000003019 stabilising effect Effects 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses a microemulsion for preventing cardiovascular diseases and a preparation method thereof and relates to the field of healthcare food. The microemulsion is prepared from vitamin E, phytosterol ester, camellia oil, a surfactant, vitamin C, a preservative, sucralose, an acidulant and a cosurfactant by the following steps: dissolving the vitamin C, sucralose, preservative and acidulant in distilled water, and adding Tween-80 to obtain clear transparent liquid; adding the vitamin E and phytosterol ester into the camellia oil, and stirring uniformly; adding the surfactant and mixing and stirring to obtain yellow clear transparent liquid; and slowly adding the yellow clear transparent liquid into the clear transparent liquid to finally obtain a clear transparent orange-yellow water-in-oil emulsion. Compared with prior art, the emulsion can help reducing cholesterol, and the cholesterol is transformed into bile acid so as to prevent arteriosclerosis and thrombus formation in blood vessels, keep smooth blood of artery blood vessels and prevent cardiovascular diseases; and moreover, the microemulsion has good taste and attractive appearance.
Description
Technical field
The present invention relates to technical field of health care food, a kind of microemulsion preventing cardiovascular disease and preparation side thereof
Method.
Background technology
Cardiovascular and cerebrovascular disease is the general designation of cardiovascular and cerebrovascular disease, refers to owing to hyperlipemia, blood are sticky, dynamic
Ischemic that heart that pulse atherosclerosis, hypertension etc. are caused, brain and body tissue occur or hemorrhage.Heart and brain blood
Pipe disease is a kind of serious threat mankind, the commonly encountered diseases of particularly more than 50 years old middle-aged and elderly people health, has high prevalence, high cause
Residual rate and the feature of high mortality, even if the treatment means that application is most advanced, perfect, still can have the cerebrovascular of more than 50%
It is unexpected that survivor life can not take care of oneself completely, and the whole world is died from the number of cardiovascular and cerebrovascular disease every year and is up to 15,000,000 people, occupies each
Plant the cause of the death the first.
Therefore, for cardiovascular and cerebrovascular disease, the most economically, family's angle, or from the point of view of health perspectives, the most in advance
Prevent being necessary.
Oleum Camelliae is the distinctive woody oils and fats of China, its fatty acid composition and the best Vegetable oil lipoprotein Fructus Canarii albi generally acknowledged in the world
Oil phase seemingly, has the laudatory title of " east olive oil ", but Camellia oil contains olive oil unexistent given activity material, contains in Oleum Camelliae
Several functions composition, such as camellin, Flos Camelliae Japonicae Saponin, tea polyphenols etc..Wherein camellin has cardiotonic, Tsubaki-saponin to have haemolysis
Bolt effect, and tea polyphenols has the reduction multiple effect such as cholesterol, chemoprophylaxis.Additionally, unsaturated fatty acid content in Oleum Camelliae
Height, wherein monounsaturated fatty acid oleic acid content is the abundantest.Oleic acid is a kind of high-quality and safety fatty acid, easily by human body
Absorbing, be difficult to again oxide deposition in internal, antioxidative effect is more preferable than polyunsaturated fatty acid, will not cause in blood of human body
The increase of cholesterol (TC) concentration, and the same with polyunsaturated fatty acid can reduce low-density lipoprotein cholesterol in blood
(LDL L), but do not reduce and even improve blood high-density lipoprotein cholesterol (HDL C), can effectively prevent and control
Treat the cardiovascular disease such as coronary heart disease, hypertension.
But Oleum Camelliae scent of, and greasy heavy, directly take and be difficult to obtain consumers in general's acceptance, add that it belongs to oiliness thing
Matter, is difficult to add thereto water-solubility function material.If imaging beverage based food can be done, both had good functional, mouth again
Taste is all good, will obtain the favor of consumer at different levels.
Summary of the invention
One of problem to be solved by this invention is to provide a kind of prevention with good prevention cardiovascular disease function
The microemulsion of cardiovascular disease.
In order to solve above-mentioned technical problem, scheme of the present invention is:
It includes the raw material of following weight percents:
Camellia oil 40-45%, vitamin E 0.1-0.2%, plant sterol ester 0.1-0.5%, surfactant 45-50%, vitamin
C 0.1-0.2%, preservative 0.03-0.05%, sucralose 0.05-0.08%, acidic flavoring agent 0.5-0.8%, cosurfactant
Aqueous solution surplus.
In technique scheme, more specifically scheme it may also is that described surfactant be Span-80, Span-85,
Any one in hard fatty acids monoglyceride or sucrose fatty acid ester series and the mixture of Tween-80, ratio presses HLB value ≈ 7
Regulation.
Further: described cosurfactant is the one in PEG-4000, propylene glycol；Described help surface activity
The concentration of agent aqueous solution is 20%；Described preservative is sorbic acid and potassium salt thereof.
The two of problem to be solved by this invention are to provide a kind of microemulsion making simply and making to be had well
The preparation method of microemulsion of prevention cardiovascular disease function.
In order to solve above-mentioned technical problem, scheme of the present invention is:
Use the raw material of following percentage by weight:
Camellia oil 40-45%, vitamin E 0.1-0.2%, plant sterol ester 0.1-0.5%, surfactant 45-50%, vitamin
C 0.1-0.2%, preservative 0.03-0.05%, sucralose 0.05-0.08%, acidic flavoring agent 0.5-0.8%, cosurfactant
Aqueous solution surplus；
Described surfactant is Span-80, appointing in Span-85, hard fatty acids monoglyceride or sucrose fatty acid ester series
A kind of mixture with Tween-80, ratio is regulated by HLB value ≈ 7；
Its preparation process is:
(1) soluble in water to vitamin C, sucralose, preservative and acidic flavoring agent, it is subsequently adding cosurfactant, stirs molten
Solve；
(2) under stirring, it is slowly added into Tween-80 toward step (1) gained solution, obtains clear transparent solutions；
(3) in Camellia oil, add vitamin E, plant sterol ester, stir, be subsequently adding surfactant, mix and blend
Uniformly, yellow clear transparent solutions is obtained；
(4) mechanical agitation is slowly added to step (2) gained solution in step (3) gained solution, finally gives clear
Orange-yellow water-in-oil emulsion.
Further: described cosurfactant is the one in PEG-4000, propylene glycol, described in help surface activity
The concentration of agent aqueous solution is 20%；Described preservative is sorbic acid and potassium salt thereof.
Microemulsion (Microemulsion, ME) described in the present invention is the Thermodynamically stable that two kinds of mutual insoluble liq are formed
, isotropic, appearance transparent or translucent dispersion.It is typically oil, water, emulsifying agent and co-emulsifier to spontaneously form
Isotropism, the thermodynamics and kinetics stabilising system of clear.It is widely used in daily-use chemical industry, tertiary oil recovery,
The aspects such as enzyme catalysis.Owing to microemulsion is in addition to the general aspects with Emulsion, also have stable, clear, particle diameter are little
Advantage, has obtained increasing attention in the field such as pharmaceutical preparation and clinic the most in recent years.Microemulsion divides according to structure
For oil-in-water type, water-in-oil type and bicontinuous.Water oil-packaging type micro-emulsion can Solubilization of Water soluble drug, improve water soluble drug
Stability and bioavailability.
Plant sterol ester of the present invention has and preferably reduces blood cholesterol level, alleviates cardiovascular disease effect.
Within 2000, FDA (FDA) approval sterol ester uses as functional food ingredient.FDA thinks, everyone
As long as every day takes in more than 1.3g phytosterin fatty acid ester can reduce the purpose of cholesterol.In terms of medicine, plant
Sterol ester also can alleviate atherosclerosis as regulation hypercholesterolemia medicine simultaneously, prevents prostatosis, anticancer, anti-
Virus and antiinflammatory etc..
Vitamin E, as antioxidant, adds to and food can be made in food to keep after processing stablizing lasting fresh wind
Taste, it is also possible to for the production of functional health condensed food, in particular as antioxidant, the nutrition enhancer of infant food
Deng；In the RDA that national research council (NRC) in 2000 and food nutrition committee (FNB) formulate, vitamin E of being grown up
Quantity delivered is 15 mg/d.In terms of medicine, vitamin E has significant antitumor, prevention cardiovascular disease, improves body
The functions such as immunity；In terms of cosmetics, VE is the important component in beauty treatment skin moistening, anti-aging cosmetics；Food adds dimension
Raw element C can help to reduce cholesterol, cholesterol is converted into bile acid, thus helps prevention of arterial to harden；Vitamin C can
Help the formation of thrombosis in prevention blood vessel, maintain arteries blood flow unobstructed, the generation of prevention cardiovascular disease.Additionally supplement dimension
Raw element C can also help prophylaxis of hypertension.
The present invention compared with prior art, has the advantages that
1, this microemulsion has plant sterol ester, vitamin E and vitamin C due to compounding, it is possible to help to reduce cholesterol, and gallbladder is solid
Alcohol is converted into bile acid, thus helps prevention of arterial hardening and help the formation of thrombosis in prevention blood vessel, maintains arteries blood
Circulation is smooth, the generation of prevention cardiovascular disease.
2, making microemulsion owing to Camellia oil is mixed with emulsifying agent, it has good functional, good taste, it is thus achieved that
The favor of consumers at different levels.
Detailed description of the invention
Below in conjunction with instantiation, the invention will be further described:
Embodiment 1:
Use the raw material of following metering: Camellia oil 44.6 kilograms, vitamin E 0.2 kilogram, plant sterol ester 0.3 kilogram, surface
Activating agent Span-80 36 kilograms, surfactant Tween-80 12 kilograms, vitamin C 0.2 kilogram, preservative sorbic acid
0.03 kilogram, sucralose 0.08 kilogram, acidic flavoring agent, 0.8 kilogram, cosurfactant PEG-4000 1.18 kilograms,
Distilled water 4.70 kilograms；
Preparation process is:
(1) soluble in water to vitamin C, sucralose, preservative and acidic flavoring agent, it is subsequently adding the poly-second of cosurfactant two
Alcohol-400, stirring and dissolving；
(2) under stirring, it is slowly added into Tween-80 toward step (1) gained solution, obtains clear transparent solutions；
(3) in Camellia oil, add vitamin E, plant sterol ester, stir, be subsequently adding surfactant Span-80, mixed
Conjunction stirs, and obtains yellow clear transparent solutions；
(4) mechanical agitation is slowly added to step (2) gained solution in step (3) gained solution, finally gives clear
Orange-yellow water-in-oil emulsion.
Embodiment 2:
Use the raw material of following metering: Camellia oil 40 kilograms, vitamin E 0.1 kilogram, plant sterol ester 0.5 kilogram, live in surface
Property agent Span-85 33.33 kilograms, surfactant Tween-80 16.67 kilograms, vitamin C 0.1 kilogram, preservative Pyrusussuriensis
0.05 kilogram of potassium of acid, sucralose 0.05 kilogram, acidic flavoring agent 0.5 kilogram；Cosurfactant propylene glycol 1.8 kilograms, distillation
7.44 kilograms of water；
Preparation process is:
(1) soluble in water to vitamin C, sucralose, preservative and acidic flavoring agent, it is subsequently adding cosurfactant propylene glycol,
Stirring and dissolving；
(2) under stirring, it is slowly added into Tween-80 toward step (1) gained solution, obtains clear transparent solutions；
(3) in Camellia oil, add vitamin E, plant sterol ester, stir, be subsequently adding surfactant Span-85, mixed
Conjunction stirs, and obtains yellow clear transparent solutions；
(4) mechanical agitation is slowly added to step (2) gained solution in step (3) gained solution, finally gives clear
Orange-yellow water-in-oil emulsion.
Embodiment 3:
Use the raw material of following metering: Camellia oil 42.75 kilograms, vitamin E 0.15 kilogram, plant sterol ester 0.1 kilogram, table
Face activating agent hard fatty acids monoglyceride 33.33 kilograms, Tween-8016.67 kilogram of surfactant, vitamin C 0.15 thousand
Gram, preservative sorbic acid 0.04 kilogram, sucralose 0.06 kilogram, acidic flavoring agent 0.65 kilogram；Cosurfactant propylene glycol
1.22 kilograms, distilled water 4.88 kilograms；
Preparation process is:
(1) soluble in water to vitamin C, sucralose, preservative and acidic flavoring agent, it is subsequently adding cosurfactant propylene glycol,
Stirring and dissolving；
(2) under stirring, it is slowly added into Tween-80 toward step (1) gained solution, obtains clear transparent solutions；
(3) in Camellia oil, add vitamin E, plant sterol ester, stir, be subsequently adding surfactant hard fatty acids list
Glyceride, mixing and stirring, obtain yellow clear transparent solutions；
(4) mechanical agitation is slowly added to step (2) gained solution in step (3) gained solution, finally gives clear
Orange-yellow water-in-oil emulsion.
Example 4:
Use the raw material of following metering: Camellia oil 44.8 kilograms, vitamin E 0.1 kilogram, plant sterol ester 0.1 kilogram, surface
Activating agent sucrose fatty acid ester (SE-3) 30 kilograms, Tween-8015 kilogram of surfactant, vitamin C 0.2 kilogram, anticorrosion
Agent potassium sorbate 0.05 kilogram, sucralose 0.05 kilogram, acidic flavoring agent 0.8 kilogram；Cosurfactant PEG-4000
1.98 kilograms, distilled water 7.1 kilograms；
Preparation process is:
(1) soluble in water to the vitamin C in component C, sucralose, preservative and acidic flavoring agent, it is subsequently adding and helps surface activity
Agent PEG-4000, stirring and dissolving；
(2) under stirring, it is slowly added into Tween-80 toward step (1) gained solution, obtains clear transparent solutions；
(3) in Camellia oil, add vitamin E, plant sterol ester, stir, be subsequently adding surfactant sucrose-fatty
Ester (SE-3), mixing and stirring, obtain yellow clear transparent solutions；
(4) mechanical agitation is slowly added to step (2) gained solution in step (3) gained solution, finally gives clear
Orange-yellow water-in-oil emulsion.
Example 5:
Use the raw material of following metering: Camellia oil 44.3 kilograms, vitamin E 0.2 kilogram, plant sterol ester 0.5 kilogram, surface
Activating agent sucrose fatty acid ester (SE-1) 30 kilograms, Tween-8020 kilogram of surfactant, vitamin C 0.1 kilogram, anticorrosion
Agent sorbic acid 0.01 kilogram, sucralose 0.05 kilogram, acidic flavoring agent 0.5 kilogram；Cosurfactant PEG-4000 0.
87 kilograms, distilled water 3.47 kilograms；
Preparation process is:
(1) soluble in water to vitamin C, sucralose, preservative and acidic flavoring agent, it is subsequently adding the poly-second of cosurfactant two
Alcohol-400, stirring and dissolving；
(2) under stirring, it is slowly added into Tween-80 toward step (1) gained solution, obtains clear transparent solutions；
(3) in Camellia oil, add vitamin E, plant sterol ester, stir, be subsequently adding surfactant sucrose-fatty
Ester (SE-1), mixing and stirring, obtain yellow clear transparent solutions；
(4) mechanical agitation is slowly added to step (2) gained solution in step (3) gained solution, finally gives clear
Orange-yellow water-in-oil emulsion.
Claims (5)
1. the microemulsion preventing cardiovascular disease, it is characterised in that include the raw material of following weight percents:
Camellia oil 40-45%, vitamin E 0.1-0.2%, plant sterol ester 0.1-0.5%, surfactant 45-50%, vitamin
C 0.1-0.2%, preservative 0.03-0.05%, sucralose 0.05-0.08%, acidic flavoring agent 0.5-0.8%, cosurfactant
Aqueous solution surplus.
The microemulsion of prevention cardiovascular disease the most according to claim 1, it is characterised in that: described surfactant is
Any one in Span-80, Span-85, hard fatty acids monoglyceride or sucrose fatty acid ester series and the mixing of Tween-80
Thing, ratio is regulated by HLB value ≈ 7.
The microemulsion of prevention cardiovascular disease the most according to claim 1 and 2, it is characterised in that help surface activity described in:
Agent is the one in PEG-4000, propylene glycol, and the concentration of described cosurfactant aqueous solution is 20%；Described preservative
For sorbic acid and potassium salt thereof.
4. the preparation method of the microemulsion preventing cardiovascular disease, it is characterised in that use the former of following percentage by weight
Material:
Camellia oil 40-45%, vitamin E 0.1-0.2%, plant sterol ester 0.1-0.5%, surfactant 45-50%, vitamin
C 0.1-0.2%, preservative 0.03-0.05%, sucralose 0.05-0.08%, acidic flavoring agent 0.5-0.8%, cosurfactant
Aqueous solution surplus；
Described surfactant is Span-80, arbitrary in Span-85, hard fatty acids monoglyceride, sucrose fatty acid ester series
Planting the mixture with Tween-80, ratio is regulated by HLB value ≈ 7；
Its preparation process is:
(1) soluble in water to vitamin C, sucralose, preservative and acidic flavoring agent, it is subsequently adding cosurfactant, stirs molten
Solve；
(2) under stirring, it is slowly added into Tween-80 toward step (1) gained solution, obtains clear transparent solutions；
(3) in Camellia oil, add vitamin E, plant sterol ester, stir, be subsequently adding surfactant, mix and blend
Uniformly, yellow clear transparent solutions is obtained；
(4) mechanical agitation is slowly added to step (2) gained solution in step (3) gained solution, finally gives clear
Orange-yellow water-in-oil emulsion.
The preparation method of the microemulsion of prevention cardiovascular disease the most according to claim 4, it is characterised in that help table described in:
Face activating agent is the one in PEG-4000, propylene glycol, and the concentration of described cosurfactant aqueous solution is 20%；Described
Preservative is sorbic acid and potassium salt thereof.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113975331A (en) * | 2021-10-28 | 2022-01-28 | 湖南润农生态茶油有限公司 | Antithrombotic tea oil, preparation method and application |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102283386A (en) * | 2011-08-16 | 2011-12-21 | 中国林业科学研究院亚热带林业研究所 | Composite camellia oil health care product with function of reducing blood fat and preparation method thereof |
| CN103283866A (en) * | 2013-06-09 | 2013-09-11 | 浙江大学 | Camellia oil microemulsion and preparation method thereof |
-
2016
- 2016-04-26 CN CN201610264621.XA patent/CN105852109A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102283386A (en) * | 2011-08-16 | 2011-12-21 | 中国林业科学研究院亚热带林业研究所 | Composite camellia oil health care product with function of reducing blood fat and preparation method thereof |
| CN103283866A (en) * | 2013-06-09 | 2013-09-11 | 浙江大学 | Camellia oil microemulsion and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 山枫塘: "茶油—食用油中的佳品", 《HTTPS://WENKU.BAIDU.COM/VIEW/665C2374F242336C1EB95E7E.HTML》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113975331A (en) * | 2021-10-28 | 2022-01-28 | 湖南润农生态茶油有限公司 | Antithrombotic tea oil, preparation method and application |
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