JPH10179086A - Oil-solubilizing liquid containing plant sterol as well as drinks and their production - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an oil-solubilizing liquid which improves the absorption into the human body by oil-solubilization of plant sterol contg. sitosterol, has improved stability and is useful for decreasing the symptoms of the prostatic hypertrophy, lowering cholesterol, etc., and drinks by adding vitamin E and an emulsifying agent to the plant sterol contg. the sitosterol. SOLUTION: The plant sterol contg. the sitosterol is made soluble in oil by adding the vitamin E and the emulsifying agent to the plant sterol contg. the sitosterol. The content of the vitamin E in the plant sterol oil-solubilizing liquid is >=5wt.% and the content of the emulsifying agent (liquid at ordinary temp.) is >=5wt.%. The oil-solubilizing liquid contg. 15 to 30wt.% plant sterol contg. the oil-solubilized sitosterol is easiest to handle and is widely processed to various kinds of foods.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

[0001] The present invention relates to an oil solubilized solution, food and drink containing a plant sterol, and a method for producing the same.
For more information, such as improving prostatic hypertrophy and lowering cholesterol,
The present invention relates to an oil solution, a food and drink, and a method for producing the same, which contain a plant sterol having an effect of preventing various diseases.

[0002]

2. Description of the Related Art Plant sterols such as sitosterol are
Cholesterol absorption inhibitory action has been known for a long time,
It has been used as a hyperlipidemic drug as a clinical drug or over-the-counter drug for some time. However, since phytosterols have a poor solubility in oils and water, their formulation has been suspended in oils or provided in the form of powders or granules.

[0003] The water-solubilization of plant sterols is disclosed in JP-A-50-89520 and JP-A-53-31210, which relates to a method for producing a sterol injection and is orally administered. Not for.

[0004] Further, it is known that a plant sterol and ethylene oxide are added to improve the solubility in water or an organic solvent by the length of the added ethylene oxide chain, but this is used for toiletries. It is not used as food.

[0005] When used in an insoluble form, plant sterols are poorly absorbed or are inconvenient to be widely used in foods. In Germany, sitosterol has been used to improve symptoms of prostatic hypertrophy, but is used in powder form due to its insoluble nature.

[0006]

SUMMARY OF THE INVENTION Accordingly, an object of the present invention is to provide an oil solubilized solution and a food or beverage containing a plant sterol such as sitosterol, and particularly to provide a human body by oil solubilizing a plant sterol such as sitosterol. An object of the present invention is to provide an oil solution, a food and drink, and a method for producing the same, which contain a plant sterol with good absorption and improved stability.

[0007]

The above objects of the present invention are as follows. In foods and drinks containing plant sterols containing sitosterol, foods and drinks characterized in that vegetable sterols containing sitosterol are added with vitamin E and an emulsifier to make the plant sterols soluble in oil,

[0008] 2. The food and drink according to 1, wherein the sitosterol is extracted from a natural plant component, and is a composition containing a single or other plant sterol component.

3. 3. The food or drink according to 1 or 2, wherein the solution of vegetable sterol oil contains 5% by weight or more of vitamin E.

[0010] 4. The food or drink according to any one of claims 1 to 3, wherein the emulsifier is a liquid emulsifier at room temperature, and the emulsifier is contained in the vegetable sterol oil solution at 5% by weight or more.

5. The food or drink according to any one of claims 1 to 4, wherein the food or beverage contains 0 to 10% by weight of a glycerin ester of a medium-chain fatty acid having 6 to 12 carbon chains.

6. An oil solubilized solution containing 1 to 50% by weight of a plant sterol containing sitosterol in an oil-solubilized state,

7. 4. The oil solubilized liquid according to 4, wherein the plant sterol is solubilized in oil by adding vitamin E and an emulsifier to the plant sterol containing sitosterol.

8. The oil solubilized liquid according to 6 or 7, wherein the sitosterol is extracted from a natural plant component, and is a composition containing a single or other plant sterol component.

9. The oil solubilized solution according to 6, 7, or 8, wherein the plant sterol oil solubilized solution contains 5% by weight or more of vitamin E.

10. The oil solubilized liquid according to any one of 6 to 9, wherein the emulsifier is a liquid emulsifier at room temperature, and the emulsifier is contained in the vegetable sterol oil solubilized liquid by 5% by weight or more.

11. 6. The oil solubilized liquid according to 6, wherein vitamin E and an emulsifier which is a liquid at room temperature are used together with an emulsifier containing oleic acid or lauric acid alone or in a total amount of 60% by weight or more in a fatty acid composition.

[12] The oil solubilized liquid according to any one of 6 to 11, wherein the glycerin ester of a medium-chain fatty acid having 6 to 12 carbon chains is contained in an amount of 0 to 10% by weight.

13. A method for producing an oil-solubilized plant sterol, characterized by adding vitamin E and an emulsifier to a plant sterol containing sitosterol to make the plant sterol solubilized in oil.

In order to solve the above problems, the present inventor has
In addition to stabilizing sitosterol by solubilizing plant sterols such as sitosterol in oil, a composition having good absorption into the human body was provided, and it was easily processed into various foods. In particular, the present inventors have conducted intensive studies on the oil solubilization of sitosterol. As a result, by using the oil solubilized liquids of 7, 8, and 9, and further, simultaneously using vitamin E and an emulsifier liquid at room temperature, It has been found that a stable and well-absorbable plant sterol, which has been a problem in the past, can be prepared. Furthermore, it has been found that by adding MCT (glycerin ester of medium chain fatty acid having 6 to 12 carbon chains, particularly triglyceride), the fluidity of the composition is improved, and the tongue is also improved, so that the composition can be easily used in foods. ,
The present invention has been completed.

[0021]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The details of the present invention will be described below. The sitosterol used in the present invention is a kind of vegetable sterol, and the plant sterol is obtained by separating from scum and the like produced in a deodorizing step of a vegetable oil manufacturing plant.

Sitosterol is a kind of plant sterol which forms a cell membrane of a plant together with campesterol and stigmasterol, and sitosterol is the sterol most contained in the plant kingdom.

The sterols are classified into animal, vegetable, fungal, marine, etc., and plant sterols including sitosterol are effective in the present invention. As plant sterols other than sitosterol, stigmasterol, campesterol, brassicasterol and the like are known. Sitosterol is a sterol most frequently contained in the plant kingdom, and is widely present in plant seed oils and various parts of plants. Stigmasterol is used in soybeans, palms, cottonseed, etc.
Campesterol is contained in soybeans, rapeseed, wheat and the like, and brassicasterol is contained in rapeseed. The sitosterol used in the present invention does not need to be a separate product alone, and may be used as a mixture of the above sterols.

Vitamin E used in the present invention is α,
Any type of β, γ, δ-tocopherol may be used, and of course, there is no difference in the solubility effect even with a mixture of these. Therefore, there is no difference in solubility due to the extraction source of vitamin E.

The emulsifier used in the present invention is an emulsifier which is liquid at normal temperature, for example, glycerin fatty acid ester, diglycerin fatty acid ester, polyglycerin fatty acid ester, organic acid glycerin fatty acid ester, propylene glycol fatty acid ester, sorbitan fatty acid ester And sucrose fatty acid esters and the like can be used alone or in combination. The emulsifier does not necessarily need to be highly purified by distillation or the like, and may be a reaction mixture.

Among the above-mentioned emulsifiers, emulsifiers containing oleic acid at a high concentration are preferable, and, for example, oleic acid monoglyceride, oleic acid diglyceride, and propylene glycol oleate are improved in solubility and flowability. . Further, the emulsifier used in the present invention contributes to the improvement of the waxy unpleasant tongue of plant sterols, and can be easily and widely used in various foods.

The MCT used in the present invention is a glycerin ester of a medium-chain fatty acid having 6 to 12 carbon chains, which is contained a lot in coconut oil. Vegetable sterol is most easily dissolved in MCT in oil, and dissolves plant sterol to a concentration of about 5% by weight. Preferably, MCT having a composition of tricaprylin (C ₁₀ ) is good, and this is 7% by weight.
Dissolve the plant sterol to a concentration. With MCT alone,
Although about 7% by weight of plant sterol is dissolved, the solubility is drastically improved by using vitamin E according to the present invention and an emulsifier in combination. At this time, MCT is 0 to 10% by weight.
, But is preferably 0 to 5% by weight. The use of MCT in the present invention is extremely effective in improving the fluidity of the oil solution and, when used in combination with an emulsifier, in improving the texture. Furthermore, MCT is useful for reducing the amount of vitamin E used, and the use of MCT has great significance industrially.

In the present invention, the plant sterol containing oil-solubilized sitosterol is 1 to 50% by weight in the oil solubilized solution, and the oil solubilized solution containing 15 to 30% by weight is most easily used industrially.

As described above, plant sterols have low solubility, and therefore, when used as a cholesterol-lowering agent or an agent for improving prostatic hypertrophy, they are almost always used in the form of powder or suspension. Given that sterol dissolution in bile acid micelles is an essential condition for absorption,
The oil-solubilized plant sterol according to the present invention is more easily absorbed than the powdered or suspended one, and its pharmacological effect can be expected more.

The food, drink and food containing these oil-solubilized plant sterols are not particularly restricted but include soft capsules, microcapsules, cooking oil, shortening, dressing, margarine, butter, cheese, yogurt, and mayonnaise. , Cookies and the like. In addition, a crystal preparation such as lecithin and other additives can be added to the present invention.

[0031]

EXAMPLES Examples of the production of various foods will be described below. Example 1 A soft capsule was prepared from an oil solubilized product prepared at the following compounding ratio using a gelatin-glycerin encapsulating agent. Plant sterol (Ricesterol, manufactured by Riken Vitamin) 20% by weight Vitamin E (SDC-RD-50, manufactured by Riken Vitamin) 50% by weight Propylene glycol monooleate (Likemar PO-100, manufactured by Riken Vitamin) 30% by weight

Example 2 An oil solubilized product was prepared in the following compounding ratio. Plant sterol (Riquesterol, manufactured by Riken Vitamin Co.) 20% by weight Vitamin E (SDC-RD-50, manufactured by Riken Vitamin Co.) 45% by weight Monoglyceride reacted oleic acid (Poem OL-200, manufactured by Riken Vitamin Co.) 16% by weight Glycol monooleate (Riquemar PO-100, manufactured by Riken Vitamin) 15% by weight MCT (Actor M-2, manufactured by Riken Vitamin) 5% by weight

Next, a dressing was prepared using the oil solubilized product in the following composition. The above oil solubilized substance 90 g Salad oil 570 g Western vinegar 250 g Mustard 1 g Pepper 1 g Lemon juice 45 g Onion juice 35 g Na glutamate 3 g Salt 5 g

Example 3 A mayonnaise was prepared using the oil solubilized product prepared in Example 2 with the following composition. The above oil solubilized substance 90 g Salad oil 646 g Vinegar 120 g Egg yolk 100 g Eggplant 20 g Na glutamate 2 g Salt 22 g

Example 4 Using the oil solubilized product prepared in Example 2, margarine was prepared according to the following formulation. Oil solubilized product 300 g Oil (liquid oil + hardened oil) 520 g Water 148.5 g Skim milk powder 15 g Salt 15 g Lecithin 1 g Flavor 0.49 g β-carotene 0.01 g

Example 5 Using the margarine prepared in Example 4, a cookie was prepared with the following composition. Margarine of Example 4 200 g Butter 100 g Sugar 180 g Egg white 55 g Soft flour 461 g Baking soda 1 g Salt 3 g

Next, effective examples of the present invention will be described. Men who are prone to dysuria due to prostatic hypertrophy (age 38-74, average 5
14 patients (9 years old) received two soft capsules of the oil solubilized product of Example 1 containing 30 mg of sitosterol three times a day after each meal for 3 months, and before and after the change in urination Was self-diagnosed according to the International Prostate Symptom Score (IPSS) shown in Table 1, and the results were shown in Table 2 and FIG.
And 2.

[0038]

[Table 1]

[0039]

[Table 2]

From Table 2 and FIGS. 1 and 2, the effectiveness of the present invention in improving urination disorders due to prostatic hypertrophy was confirmed.

The same effect as that of the cookie of Example 5 was observed in the same experiment as in Example 1.

[0042]

Industrial Applicability According to the present invention, it is possible to stabilize sitosterol by dissolving plant sterols such as sitosterol in oil, to provide a composition having good absorption into the human body, and to easily process a wide variety of foods. It is possible to provide an oil solution, a food and drink, and a method for producing the same, which have an effect of improving prostatic hypertrophy.

[Brief description of the drawings]

FIG. 1 is an item transition graph showing a result of an embodiment.

FIG. 2 is also a graph showing IPSS trends

────────────────────────────────────────────────── ─── Continued on the front page (51) Int.Cl. ⁶ Identification code FI B01J 13/00 B01J 13/00 A // A23L 1/24 A23L 1/24 A

Claims (13)

[Claims] 1. A food or beverage containing a plant sterol containing sitosterol, wherein the plant sterol is solubilized in oil by adding vitamin E and an emulsifier to the plant sterol containing sitosterol. 2. The food or drink according to claim 1, wherein said sitosterol is extracted from a natural plant component, and is a composition containing one or another plant sterol component. 3. The food or drink according to claim 1, wherein the solution of vegetable sterol oil contains 5% by weight or more of vitamin E. 4. The food or drink according to claim 1, wherein the emulsifier is a liquid emulsifier at room temperature, and the emulsifier is contained in the vegetable sterol oil solution in an amount of 5% by weight or more. 5. The food or drink according to claim 1, which contains 0 to 10% by weight of a glycerin ester of a medium-chain fatty acid having 6 to 12 carbon chains. 6. An oil solubilized solution containing 1 to 50% by weight of a plant sterol containing sitosterol solubilized in oil. 7. The oil solubilized liquid according to claim 4, wherein the plant sterol is solubilized in oil by adding vitamin E and an emulsifier to the plant sterol containing sitosterol. 8. The oil solubilized liquid according to claim 6, wherein the sitosterol is extracted from natural plant components and is a composition containing one or more other plant sterol components. 9. The method according to claim 6, wherein the solution of vegetable sterol oil contains 5% by weight or more of vitamin E.
The oil solubilized liquid as described above. 10. The emulsifier is a liquid emulsifier at room temperature,
The oil solubilized solution according to any one of claims 6 to 9, wherein 5% by weight or more is contained in the plant sterol oil solubilized solution. 11. The method according to claim 6, wherein the fatty acid composition contains vitamin E and an emulsifier which is liquid at ordinary temperature and which contains at least 60% by weight of oleic acid or lauric acid alone or in combination. Oil solubilized liquid. 12. The oil solubilized liquid according to claim 6, which contains 0 to 10% by weight of a glycerin ester of a medium-chain fatty acid having 6 to 12 carbon chains. 13. A process for producing an oil-solubilized plant sterol, comprising adding vitamin E and an emulsifier to a plant sterol containing sitosterol to make the plant sterol solubilized in oil.