WO2005097152A1

WO2005097152A1 - Turmeric extract-containing composition having improved caking capacity

Info

Publication number: WO2005097152A1
Application number: PCT/JP2005/005175
Authority: WO
Inventors: Toshinori Ikehara
Original assignee: Kaneka Corporation
Priority date: 2004-03-31
Filing date: 2005-03-23
Publication date: 2005-10-20
Also published as: JPWO2005097152A1

Abstract

Concerning the utilization of turmeric having extremely useful physiological functions, attempts are made to improve the unfavorable caking capacity (i.e., a tendency toward caking due to its high viscosity and oily nature) of a turmeric extract to thereby overcome problems such as the poor fluidity and stickiness to containers. Thus, a composition containing a turmeric extract, which is difficult in handling as such, at a high concentration is provided. Using this turmeric extract-containing composition characterized by containing more than 40% by weight of a turmeric extract and comprising a fat and/or a lipophilic emulsifier having an HLB of 8.5 or less, useful components of turmeric are packed at a high concentration into a soft capsule or the like.

Description

Specification

Composition containing konkon extract with improved caking properties

Technical field

TECHNICAL FIELD [0001] The present invention relates to a composition containing a cocoon extract with improved caking properties, which facilitates the use of a cocoon extract having an effect of preventing or improving multiple 'risk' factor syndromes.

Background art

[0002] Ginger, which is classified into the genus Gingidae (spring gong: Curcuma aromatica, autumn gong:

Curcuma longa) is generally known as turmeric, one of the curry spices, and is widely used as food. On the other hand, traditional therapies such as Chinese herbal medicine, Indian aurveda, and Indonesian jams have long been known to have haemostatic, stomach, antibacterial and anti-inflammatory effects. It's being used. Attention has also been paid to the effects of turmeric and its major component, curcumin, which have antioxidant effects, bile secretion promoting effects (biliary effects), visceral (liver, visceral) function enhancing effects, carcinogenesis suppressing effects, lipid metabolism improving effects, and whitening. Various physiological actions such as actions have been elucidated. Furthermore, it is known that konkon extract has an effect of preventing or improving the multiple risk factor syndrome such as visceral fat obesity, diabetes, hyperlipidemia and hypertension (International Publication No. 476 99 pamphlet), icon is an extremely useful material having various functions.

[0003] However, the konkon extract (ゥ konoleoresin) is curcumin and curcumin derivatives

Since it contains terpenes such as pisaborane-type sesquiterpenes in addition to (talcuminoids), its properties are high-viscosity oil and exhibit caking properties, and it has no problem due to poor fluidity and adhesion to containers. In such cases, it was extremely difficult to enclose in soft capsules, for example. In addition, the use of corn extract has become difficult, and its use has been limited, for example, an alcohol-ketone organic solvent must be used to make the solution difficult to dissolve in water-triglyceride. In the pamphlet of WO02 / 47699, there is a description of a soft capsule using a coconut extract (40 parts by weight of konkon extract, 55 parts by weight of sesame oil, 5 parts by weight of glycerin fatty acid ester).記 Notes on properties of corn extract No specific mention was made of the details of the emulsifier incorporated in the product, and the caking properties were actually evaluated using Emulgy MS (manufactured by RIKEN Vitamin Co., HLB = 4.3) as a glycerin fatty acid ester. After that, soft capsules could be made at the laboratory level, but it was impractical to make soft capsules industrially. Therefore, it is clear that the present invention has no suggestion.

[0004] As a means for solving such a problem in using the icon extract, a mixture of the icon extract and the wine has been proposed (JP-A-9-111282). According to this method, it is possible to obtain a non-caking solid at room temperature, but the content of strawberry extract is limited to about 50%. In addition, the use of an organic solvent such as hydrous ethanol in the production process and the step of drying the solution are necessary, so that the product must be expensive.

[0005] Further, extraction of edible oils and fats from sesame powder with diglycerides has also been proposed (JP-A-2001-86931, JP-A-2003-137799). According to this method, it is possible to obtain an oil containing the active ingredient of a cocoon, but its concentration is only about 1%, which is not as high as that of the present invention, and is only about 1%. In order to obtain a great physiological effect, a large amount of the oil must be taken, which is not practical.

Patent Document 1: WO 02/47699

Patent Document 2: JP-A-9-111282

Patent Document 3: JP 2001-86931A

Patent Document 4: JP-A-2003-137799

Disclosure of the invention

Problems to be solved by the invention

[0006] An object of the present invention relates to the use of a macaque extract having an extremely useful physiological action, and solves the problems of poor fluidity and adhesion to containers and the like by improving the above-mentioned undesirable properties. Another object of the present invention is to provide a composition containing a high concentration of corn extract, which is extremely difficult to handle as it is.

Means for solving the problem

[0007] In view of the above-mentioned circumstances, the present inventors have conducted intensive studies and as a result, by mixing a cocoon extract with an edible oil / fat and / or a specific emulsifier, the caking property was remarkably improved, and the cocoon extract was improved The present inventors have found that a slurry having good fluidity can be obtained even if it is contained at a concentration, and have completed the present invention.

[0008] That is, a first aspect of the present invention is that a lipophilic emulsifier containing a corn extract in an amount of more than 40% by weight, and having a medium chain fatty acid triglyceride and Z or fat and / or HLB value of 8.5 or less. The present invention relates to a composition comprising a grape extract. A preferred embodiment relates to the composition described above, characterized by comprising a medium-chain fatty acid triglyceride and a lipophilic emulsifier having a Z or HLB value of 8.5 or less. More preferably, the lipophilic emulsifier is a glycerin fatty acid ester, the composition containing a coconut extract described above, and further preferably, the lipophilic emulsifier is a polyglycerin fatty acid ester. The corn extract extract-containing composition, particularly preferably the corn extract extract-containing composition described above, wherein the constituent fatty acids of the polyglycerin fatty acid ester are unsaturated fatty acids, and very preferably the lipophilic emulsifier is diglycerin monoester. The above-mentioned composition comprising a cocoon extract, which is an ester of oleic acid, and most preferably the effect of preventing or ameliorating multiple 'risk' factor syndrome. Extract-containing composition.

[0009] A second aspect of the present invention relates to a capsule enclosing the above-described composition.

[0010] A composition having a high viscosity and a low adherence to a container or the like can be provided despite containing a high concentration of a corn extract. Therefore, for example, it becomes easy to encapsulate the useful component of the cocoon in a soft capsule or the like at a high concentration.

The invention's effect

[0011] Although the composition of the present invention has a very useful physiological activity, it has a high viscosity, a caking property, a poor fluidity and often adheres to a container. By mixing a medium-concentrated triglyceride and / or fat and oil and a lipophilic emulsifier having a Z or HLB value of 8.5 or less with a high-concentration corn extract having a high concentration, the fluidity, adhesion and uniformity are excellent. Has advantages. In addition, the composition containing the cocoon extract of the present invention has an advantage that it has an effect of preventing or ameliorating multiple 'risk' factor syndromes because it contains a high concentration of the cocoon extract. Furthermore, since the composition containing a cocoon extract of the present invention is excellent in fluidity, adhesion and uniformity, a soft capsule containing a high-concentration cocoon extract can be used. It has the advantage that it can be easily manufactured.

BEST MODE FOR CARRYING OUT THE INVENTION

Hereinafter, the present invention will be described in detail. The cocoon extract-containing composition of the present invention is obtained by mixing a cocoon extract with an oil component, which improves fluidity, and / or a lipophilic emulsifier, which improves cohesion.

[0013] The method for producing the icon extract of the present invention is not particularly limited, and it can be obtained by a conventionally known method, for example, a method of extracting the rhizome of the icon with warm ethanol. It is also possible to use commercially available Coneole Resin as it is.

[0014] Further, the iconic extract used in the present invention includes curcumin, curcumin derivatives (eg, demethoxycurcumin, bisdemethoxycurcumin, dihydrocurcumin, tetrahydrocurcumin, hexahydrocurcumin, dihydroxytetracurcumin, etc.) and pisaborane-type The sesquiterbene includes, for example, 1-bisabolene, α-curcumene, gingiberene, 1-sesquiferandrene, ar-turmerone, α-turmerone, and 3-turmerone.

[0015] The medium-chain fatty acid triglyceride (hereinafter also referred to as MCT) used in the present invention is a triglyceride having a fatty acid residue having 6 to 10 carbon atoms as a constituent fatty acid residue.

[0016] The fats and oils used in the present invention are edible fats and oils other than medium-chain fatty acid triglycerides, and are not particularly limited. For example, vegetable oils such as corn oil, rapeseed oil, high cinnamon rape oil, soybean oil, olive oil, safflower oil, cottonseed oil, castor oil, rice bran oil, palm oil, palm kernel oil, etc., fish oil, beef tallow, lard, milk fat, egg yolk Animal oils such as oils, oils and fats which have been subjected to separation, hydrogenation, transesterification and the like using these as raw materials, or mixed oils thereof can be used. For applications other than foods, it is also possible to select fats and oils other than the above animal and vegetable fats and oils.

[0017] The lipophilic emulsifier used in the present invention is not particularly limited as long as it can be uniformly mixed with the cocoon extract or the cocoon extract and fats and oils, but the HLB value is preferably 8.5 or less, more preferably 3 or less. —8.5, more preferably 5-8.5. This is because it is preferable that the solvent used for extracting the cocoon be closer to the lipophilicity. However, the lipophilicity mentioned here means that it can be dissolved in fats and oils, and those that can be dissolved in MCT or general edible fats and oils are defined as lipophilic emulsifiers. When the HLB value exceeds 8.5, emulsifiers are separated from cocoon extract and oils and fats May be.

[0018] The HLB value is generally a measure of the degree of hydrophilicity and lipophilicity of an emulsifier, and the smaller the value, the stronger the lipophilicity. The method for determining the HLB value is not particularly limited, but can be determined, for example, by the following formula (see Dani Gakushi Dictionary, Tokyo Kagaku Dojin, 1st edition, published on October 1, 1994).

[0019] HLB = 20 X (l-S / A)

S: Känig value of ester, A: Acid value of fatty acid

Examples of such emulsifiers include glycerin fatty acid esters such as monoglycerin fatty acid ester, monoglycerin fatty acid organic acid ester, polyglycerin fatty acid ester, polyglycerin condensed ricinoleate ester, sorbitan fatty acid esters, polysorbates, Sugar fatty acid esters, propylene glycol fatty acid esters, lecithin and the like can be mentioned, and at least one of them can be used in combination. Among them, polyglycerin fatty acid esters and polyglycerin condensed ricinoleate are more preferable, since glycerin fatty acid esters are preferred because they can effectively improve the caking property. The caking property as referred to in the present invention means a balance between fluidity, adhesion to a container, and uniformity of each component of a composition containing a cocoon extract. The better the above three properties, the better the caking property. Also means good

[0020] Examples of the polyglycerin fatty acid ester and the polyglycerin condensed ricinoleate include an average degree of polymerization of polyglycerin of 2 to 10. Further, examples of the polyglycerin fatty acid ester include those in which the constituent fatty acid is a fatty acid having 6 to 22 carbon atoms. Among them, the constituent fatty acid is preferably an unsaturated fatty acid. For example, diglycerin monooleate, Tetraglycerin pentaoleate, hexaglycerin pentaoleate, pentaglycerin trioleate, decaglycerin pentaoleate, decaglycerin decaoleate, decaglycerin depot oleate, etc. Preferred and more preferred are diglycerin monooleates.

[0021] As the lipophilic emulsifier having an MCT, fat or HLB value of S8.5 or less, at least one of them can be used as long as it can be uniformly mixed with a cocoon extract.程 As the content of corn extract increases, lipophilic emulsifiers with MCT and Z or HLB values of 8.5 or less are preferred. A mixture of lipophilic emulsifiers having an MCT and HLB value of 8.5 or less is more preferred. MCT is known to have a lower viscosity than general fats and oils and an effect of suppressing body fat.It is a uniform and fine slurry compared to general fats and oils, and has a large effect of improving fluidity and uniformity. A lipophilic emulsifier having an HLB value of 8.5 or less has a large effect of improving adhesion.

Here, the contents of the cocoon extract, the medium-chain fatty acid triglyceride and / or the fat and oil, and the lipophilic emulsifier having a Z or HLB value of 8.5 or less in the cocoon extract-containing composition will be described in detail. The lipophilic emulsifier having a medium chain fatty acid triglyceride and / or fat and / or Z or HLB value of 8.5 or less according to the present invention includes MCT alone, fat and oil alone, lipophilic emulsifier alone having an HLB value of 5 or less, MCT and Combination of fats and oils, Combination of MCT and lipophilic emulsifier with HLB value of 5 or less, Combination of fats and oils with lipophilic emulsifier with HLB value of 8.5 or less, MCT and fat with HLB value of 8.5 or less Combined with a lipophilic emulsifier. These combinations can be appropriately selected depending on the content of the Japanese extract.

[0023] That is, when the content of the coconut extract in the composition containing the coconut extract is 40% by weight or less, the lipophilic emulsifier having an MCT and / or fat and / or HLB value of 8.5 or less is 60% by weight or more. It is. In this case, MCT alone, fat alone, lipophilic emulsifier alone, combined use of MCT and fat, combined use of MCT and lipophilic emulsifier, combined use of fat and oil with lipophilic emulsifier, combined use of MCT with fat and oil and lipophilic emulsifier Good combination of,

[0024] Similarly, when the content of the iconic extract is more than 0% by weight and less than 50% by weight, MCT alone, a lipophilic emulsifier alone, a combination of MCT and a fat or oil, a combination of MCT and a lipophilic emulsifier, a fat or oil, The combined amount of MCT, lipophilic emulsifier, and MCT, fat and oil, and lipophilic emulsifier in any combination is more than 50% by weight and less than 60% by weight. Since the effect of improving caking properties may not be practical with fats and oils alone, the weight ratio of fats and fats to lipophilic emulsifiers, which is preferably used in combination with MCT or with lipophilic emulsifiers, is 99.9 / 0.1-0.1 / 99.9 is preferred, and more preferably 90/10-0.1 / 99.9. It is preferable to set the weight ratio of the lipophilic emulsifier to be high in order to increase the ratio of fats and oils when the priority is placed on the fluidity and to improve the adhesion.

[0025] When the content of the cocoon extract is 50% by weight or more and less than 60% by weight, MCT alone, a lipophilic emulsifier alone, a combination of MCT and a fat, a combination of MCT and a lipophilic emulsifier, Combinations of fats and lipophilic emulsifiers, combined use of MCTs and fats and lipophilic emulsifiers, in any combination, the total amount is more than 40% by weight and not more than 50% by weight. Since fats and oils alone may not sufficiently improve the caking properties, the combination of fats and oils with MCTs or the combination of fats and oils with a lipophilic emulsifier is preferred, and both fluidity and adhesion are greatly improved. To achieve good, a combination of MCT and lipophilic emulsifier is more preferable. When the fat and oil and the lipophilic emulsifier are used in combination, the weight ratio of the fat and oil to the lipophilic emulsifier is preferably 90Z10 0.1 / 99.9 force S, more preferably 75 / 25-0.1 / 99.9. The emulsifier ratio is set in a range higher than the case where the content of the product derived from corn is more than 40 wt% and less than 50 wt%. The weight ratio of oil and fat to MCT when using oil and fat together with MCT is preferably 90 / 10-0.1 / 99.9, more preferably 70 / 30-0.1 / 99.9, and even more preferably f. In addition, the ratio is 50 / 50-0.1 / 99.9, and the MCT ratio is higher and the range is set as compared with the case where the content of konkon extract is more than 0% and less than 50% by weight. It is preferable to set the weight ratio of the lipophilic emulsifier to be higher in order to increase the ratio of fats and oils when the priority is given to the fluidity and to prioritize the improvement in adhesion. When MCT is used in combination with a lipophilic emulsifier, the weight ratio of MCT to the lipophilic emulsifier is preferably 90/10 to 10/90. Within this range, both fluidity and adhesion are significantly improved.

[0026] Further, when the content of the cocoon extract is 60% by weight or more, the combination use of MCT and a lipophilic emulsifier, the combination use of a fat and oil with a lipophilic emulsifier, and the combination use of MCT with a fat and oil and a lipophilic emulsifier are preferred. Amongst the combinations, the combined amount of MCT and lipophilic emulsifier is more preferable, and the total amount is less than 40% by weight. When MCT and a lipophilic emulsifier are used in combination, the weight ratio of the MCT to the lipophilic emulsifier is not particularly limited, but is preferably 0.1 / 99.9 to 99.9 / 0.1, more preferably 10/90. 90/10, more preferably 25 / 75-75 / 25, and most preferably 40 / 60-60 / 40. When fluidity is prioritized, the ratio of fats and oils is increased to improve adhesion. If priority is given, it is preferable to set the weight ratio of the lipophilic emulsifier to be high.

[0027] The composition of the icon extract is preferably adjusted under heating conditions as needed, and more preferably at about 20-60 ° C. Specifically, for adjustment, a predetermined amount of a cocoon extract and a predetermined amount of fats and oils or Z or a lipophilic emulsifier may be uniformly mixed by stirring under a predetermined temperature heating condition, for example, a paddle mixer. , Homomixer, A homogenizer, a high-pressure homogenizer, a colloid minole, a bead mill, or the like can be used.

[0028] The composition containing the radish extract prepared by the above-described method is preferably in the form of a capsule for more effective ingestion than the power that can be added to food as it is. , Soft capsules, hard capsules, seamless capsules and the like can be used. Furthermore, various vitamins such as vitamins A, C, D, and E, and a formulation base such as beeswax and the like may be further added to the icon extract composition according to the purpose. In addition, licorice hydrophobic extract, clove extract, cinnamon extract, etc., which has the effect of preventing or ameliorating multiple 'risk' factor syndrome, or materials commonly used as foods, and food additives such as antioxidants May be added.

Example

Hereinafter, the present invention will be described more specifically with reference to Examples, but the present invention is not limited to these Examples.

20 g of the icon extract-containing composition was placed in a 50 cc glass beaker, and the state when the beaker was tilted at 45 ° downward at 25 ° C. was observed. The evaluation criteria are as follows.

◎: Flows out quickly, △: Flows out slowly, A: Flows out slowly when heated to 40 ° C, X: Almost flows out even when heated to 40 ° C, *: Emulsifier even when stirred Is not uniform and cannot be evaluated in a separated state.

[0031] Gug adhesion evaluation method>

20 g of the icon extract-containing composition was placed in a 50 cc glass beaker, the beaker was tilted downward at 45 ° C. at 25 ° C., the beaker was returned to its original position, and the state of the inner wall of the beaker after standing for 30 minutes was observed. The evaluation criteria are as follows. ◎: No adhesion to inner wall, 〇: Slight adhesion to inner wall, △: Granular adhesion to inner wall, X: Adhesive and stick to inner wall, *: Emulsifier was not uniform even after stirring and separated Can not be evaluated in the state

[0032] <Uniformity evaluation method>

ゥ The appearance and the internal phase of the composition containing the konkon extract were observed. About the evaluation criteria It is as follows. ◎: uniform and fine slurry state, 〇: uniform but granular slurry state, △: uniform when stirred, but solid-liquid separation in a short time when allowed to stand,

X: The emulsifier was not uniform even after stirring, but separated.

(Example 1)

ゥ Conoleo resin (Maruzen Pharmaceutical Co., Ltd .: Talcminoid 31%, Terpenes 39%) 50% by weight, MCT (RIKEN Vitamin Co., Ltd., trade name: Actor M2) 25% by weight, Diglycerin monoolein An acid ester (manufactured by Riken Vitamin Co., Ltd., trade name: Poem D〇_100V, HLB value = 8.0) was used in an amount of 25% by weight, and mixed with a paddle mixer under heating conditions of 40 ° C. The composition containing the extracted radish extract showed significantly improved fluidity, adhesion and uniformity, that is, very good properties with greatly improved caking properties (Table 1).

(Example 2)

© Con O Leo resin (Maruzen Pharmaceuticals Co., Ltd.) 50 wt%, MCT (Riken Vitamin Stock Company, Ltd., trade name: actor M2) 37 · 5 weight ^_0/0, diglycerol mono O rain acid ester (Riken Vitamin stock Made by the company, trade name: Poem DO-100V, HLB value = 8.0) 12.5% by weight was mixed with a paddle mixer under heating conditions of 40 ° C. The obtained composition containing the icon extract had significantly improved fluidity, adhesion and uniformity, that is, exhibited very good properties with greatly improved caking properties (Table 1).

(Example 3)

© Con O Leo resin (Maruzen Pharmaceuticals Co., Ltd.) 50 weight ^_0/0, MCT (Riken Vitamin Stock Company, Ltd., trade name: actor M2) 12 · 5 weight ^_0/0, diglycerol mono O rain acid ester (RIKEN Vitamin Co., Ltd., trade name: Poem DO-100V, HLB value = 8.0) 37.5% by weight was mixed with a paddle mixer under heating conditions of 40 ° C. The obtained composition containing the icon extract had significantly improved fluidity, adhesion and uniformity, that is, exhibited very good properties with greatly improved caking properties (Table 1).

(Example 4)

© Con O Leo resin (Maruzen Pharmaceuticals Co., Ltd.) 80 wt%, MCT (Riken Vitamin Stock Company, Ltd., trade name: actor M2) 10 weight ^_0/0, diglycerol mono O rain acid ester (Riken vitamin Co., Ltd. Product name: Poem DO—100V, HLB value = 8.0) 10% by weight The mixture was mixed with a paddle mixer under o ° c heating conditions. The obtained composition containing the radish extract had good properties with improved fluidity and adhesion, and greatly improved uniformity, that is, improved caking properties (Table 1).

(Example 5)

© Con O Leo resin (Maruzen Pharmaceuticals Co., Ltd.) 50 wt%, MCT (Riken Vitamin Stock Company, Ltd., trade name: actor M2) 5 weight ^_0/0, penta-glycerol trioleate (Taiyo Chemical Co., Ltd., Trade name: Sun Fat A-173E, HLB value = 7.0) 45% by weight was mixed with a paddle mixer under heating conditions of 40 ° C. The obtained composition containing the icon extract had good properties in which the fluidity was improved, the adhesion and the uniformity were greatly improved, and the caking property was improved (Table 1).

(Example 6)

© Con O Leo resin (Maruzen Pharmaceuticals Co., Ltd.) 50 wt%, MCT (Riken Vitamin Stock Company, Ltd., trade name: actor M2) 45 weight ^_0/0, to Kisa glycerin penta-O rain acid esters (Sakamoto Yakuhin Kogyo stock Company name, trade name: SY Glister PO-5S, HLB value = 4.9) 5% by weight was mixed with a paddle mixer under heating conditions of 40 ° C. The obtained composition containing the radish extract showed excellent properties in which fluidity and uniformity were greatly improved, adhesion was improved, and caking property was improved (Table 1).

(Example 7)

ゥ Using 45% by weight of Conoleoresin (manufactured by Maruzen Pharmaceutical Co., Ltd.) and 55% by weight of MCT (manufactured by Riken Vitamin Co., Ltd., trade name: Actor M2), mixed with a paddle mixer under heating conditions of 40 ° C. did. The obtained composition containing the radish extract showed excellent properties in which flowability was greatly improved, adhesion and uniformity were improved, and caking property was improved (Table 1).

(Example 8)

© Con O Leo resin (Maruzen Pharmaceuticals Co., Ltd.) 45 weight ^_0/0, diglycerol mono O rain acid ester (manufactured by Riken Vitamin Co., Ltd., trade name:. Poem D_〇- 100V, HLB value = 8 0) 55 wt. % And mixed with a paddle mixer under heating conditions of 40 ° C. The obtained composition containing extract of starch extract showed good properties in which fluidity and uniformity were improved, adhesion was greatly improved, and caking property was improved (Table 1). (Example 9)

After uniformly mixing 300 mg of the icon extract-containing composition of Example 1 and 30 mg of beeswax, the mixture was pressed into a gelatin film using a rotary soft capsule manufacturing apparatus to obtain a soft capsule having a content of 330 mg. The remaining amount of the contents due to adhesion in the mixing tank and the soft capsule manufacturing equipment was very small, and it was confirmed that there was no industrial problem.

(Comparative Example 1)

© Con O Leo resin (Maruzen Pharmaceuticals Co., Ltd.) 50 wt%, MCT (Riken Vitamin Stock Company, Ltd., trade name: actor M2) 25 weight ^_0/0, tetra glycerin mono O rain acid esters (Sakamoto Yakuhin Kogyo Co., Ltd. Product name: SY Glister MO_3S, HLB value = 8.8) 25% by weight was mixed with a paddle mixer under heating conditions of 40 ° C and ° C. The emulsifier was separated and the heterogeneous state was obtained in the obtained composition containing the icon extract, and its fluidity and adhesion could not be evaluated (Table 1).

(Comparative Example 2)

© Con O Leo resin (Maruzen Pharmaceuticals Co., Ltd.) 40% by weight, sesame oil (made by force de turbocharger oil stock company) 55 weight ^_0/0, mono glycerin monostearate ester (Riken Vitamin Co., Ltd., trade name: EMALGEE MS, HLB value = 4.3) 5% by weight was used and mixed with a paddle mixer at 40 under heating conditions. Although the flowability of the obtained composition containing the starch extract was improved, the adhesiveness and uniformity were not significantly improved, and the improvement of the caking property was not necessarily sufficient (see Table 1). 1). In addition, when soft capsules were prepared in the same manner as in Example 9, a considerable amount of adhesion was confirmed in the blending tank and the soft capsule manufacturing apparatus, and it was confirmed that there was a problem industrially.

(Comparative Example 3)

Using 45% by weight of Konoleo Resin (manufactured by Maruzen Pharmaceutical Co., Ltd.) and 55% by weight of rapeseed oil (manufactured by Kaneka Chemical Industry Co., Ltd.), they were mixed with a paddle mixer under a heating condition of 40 ° C. In the obtained composition containing the radish extract, none of the fluidity, adhesion and uniformity were significantly improved, and the improvement of the caking property was not necessarily sufficient (Table 1). ).

(Comparative Example 4) ゥ Coneole Resin (Maruzen Pharmaceutical Co., Ltd.) 100% by weight

And the adhesion was very poor.

[Table 1] 1

Industrial applicability

Despite containing a high concentration of corn extract, it is possible to provide a composition having a high viscosity and low adhesion to containers and the like. Therefore, for example, it becomes easy to enclose useful components of the cocoon in a soft capsule or the like at a high concentration.

Claims

The scope of the claims

[1] A coconut extract containing more than 40% by weight of a corn extract and comprising a medium-chain fatty acid triglyceride and / or fat and oil and a lipophilic emulsifier having a Z or HLB value of 8.5 or less. Extract-containing composition.

[2] The composition of claim 1 comprising a medium-chain fatty acid triglyceride and a lipophilic emulsifier having a Z or HLB value of 8.5 or less.

[3] The composition of claim 1 or 2, wherein the lipophilic emulsifier is a glycerin fatty acid ester.

[4] The composition of claim 1 or 2, wherein the lipophilic emulsifier is a polyglycerin fatty acid ester.

[5] The constituent fatty acid of the polyglycerin fatty acid ester is unsaturated.

4. The composition according to item 4 containing a konkon extract.

[6] The composition of claim 1 or 2, wherein the lipophilic emulsifier is diglycerin monooleate.

[7] The composition of claim 1, which has an effect of preventing or ameliorating multiple 'risk' factor syndromes.

[8] A capsule in which the composition according to any one of claims 11 to 7 is encapsulated.