CN105833222A - Traditional Chinese medicine composition for improving immunity and application thereof - Google Patents
Traditional Chinese medicine composition for improving immunity and application thereof Download PDFInfo
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- CN105833222A CN105833222A CN201610271612.3A CN201610271612A CN105833222A CN 105833222 A CN105833222 A CN 105833222A CN 201610271612 A CN201610271612 A CN 201610271612A CN 105833222 A CN105833222 A CN 105833222A
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Abstract
The invention discloses a traditional Chinese medicine composition for improving immunity and application thereof .The traditional Chinese medicine composition is prepared from, by mass, 5-10 parts of broccoli, 5-15 parts of mulberries, 1-6 parts of radix saposhnikoviae, 3-8 parts of white lablab beans, 1-6 parts of rhizoma atractylodis macrocephalae, 3-7 parts of dates, 3-10 parts of longan aril, 2-8 parts of fructus lycii, 1-4 parts of codonopsis pilosula, 4-12 parts of walnut kernels, 3-8 parts of black sesame, 2-8 parts of tremella fuciformis, 3-6 parts of lentinula edodes, 5-10 parts of chinese prickly ash, 1-3 parts of sword beans, 5-10 parts of rhizoma zingiberis and 2-5 parts of amino acid .The amino acid is glutamic acid or aspartic acid .Affinal drug and diet materials are selected, the composition has the effect of improving immunity, is free of toxic or side effects, safe to use and can be directly eaten as food, if people eat the composition at the moment of season alternation or temperature change in spring, the morbidity of flu and other diseases can be greatly reduced, disease cycle can be shortened if people eat the composition in the disease period, and treatment time is shortened.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine composition improving immunity and application thereof.
Background technology
Immunity, is exactly the ability of human defense's disease.Hypoimmunity is exactly to defend weakening of disease ability.The institute of people
Can survive healthily in various environment, human immune system plays conclusive effect.Around us, existence is a lot
Pathogenic factor, and, the drug resistance phenomenon that antibacterial can spread disease and exist.The problem of mankind's anti-microbial disease, just
It is dependent on the immunity of self.Enhancing immunity can anti-curing cancers.Everyone is internal all also exists cancer gene.Health is by ring
The all kinds of factor such as border, diet affects, and about ten thousand cells are undergone mutation.When nutrition supply is good, immunity is strong when, to the greatest extent
Pipe has the cell of sudden change, but under powerful immune attack, will necessarily be destroyed.In actual life, there are about ten thousand/
The people of about one, owing to the many factors such as malnutrition cause immunity to reduce so that immunologically competent cell can not identify sudden change
Cell so that it is growth and breeding, finally develops into cancer.Enhancing immunity has become a health care of current people's pay attention to day by day
Problem.
At present, on market, the health product of enhancing immunity function mainly have following a few class: ginseng class health product, vitamins are protected
Strong product, microelement kind health product, some other product improving immunity function declared.If common people have following existing
As, broadly fall into hypoimmunity and easily feel tired, but can not check organic disease wound of often catching a cold and easily infect, healing
Slow the intestines and stomach is poor.Here it is primarily referred to as somewhat eating improper with regard to vomiting and dirarrhea.In addition, often take the people of antibiotic, often endure
The people at night, people, chronic and the middle-aged and elderly people that operating pressure is big also need enhancing immunity.Chinese herbal medicine is derived from natural, passes through
The screening of thousand of years, drug effect is certain, toxic and side effects is little, the little even noresidue of residual quantity, has health care, treatment, rehabilitation etc. comprehensive
Effect, and with all Disease-resistant factors in integrally-regulated body, resist disease, enhancing immunity and increasingly closed by people
Note, many researchers and pharmaceutical producing enterprise start sight to bet the research and development of Chinese medicine.As traditional medicine elite
Chinese medicine, having abundant production and processing capacity, long-term medical practice also to make the performance effects of plurality of Chinese in China has
And be apparent from, therefore, restudy regulation immunity of organism and the extraneous cause of disease of opposing of Chinese medicine again by the viewpoint of modern medicine
The invasion and attack effect of microorganism, has the advantage of uniqueness.
Summary of the invention
It is an object of the invention to provide a kind of Chinese medicine composition improving immunity and application thereof, by a large amount of Chinese medicines
Screening combination, it is obvious that the Chinese medicine composition obtained improves immunity of organisms effect, and without any side effects, uses safety.
In order to achieve the above object, the technological means that the present invention uses is:
A kind of Chinese medicine composition improving immunity, component and each constituent mass number are as follows: Caulis et Folium Brassicae capitatae 5 ~ 10 parts, and Fructus Mori 5 ~
15 parts, Radix Saposhnikoviae 1 ~ 6 part, Semen Lablab Album 3 ~ 8 parts, the Rhizoma Atractylodis Macrocephalae 1 ~ 6 part, 3 ~ 7 parts of Fructus Jujubae, Arillus Longan 3 ~ 10 parts, Fructus Lycii 2 ~ 8 parts,
Radix Codonopsis 1 ~ 4 part, Semen Juglandis 4 ~ 12 parts, Semen Sesami Nigrum 3 ~ 8 parts, 2 ~ 8 parts of Tremella, 3 ~ 6 parts of Lentinus Edodes, 5 ~ 10 parts of Pericarpium Zanthoxyli, Semen Canavaliae 1 ~ 3
Part, Rhizoma Zingiberis 5 ~ 10 parts, 2 ~ 5 parts of aminoacid.
Described aminoacid is glutamic acid or aspartic acid.
Described a kind of Chinese medicine composition improving immunity, component and each constituent mass number are as follows: Caulis et Folium Brassicae capitatae 6 ~ 8
Part, 8 ~ 12 parts of Fructus Mori, Radix Saposhnikoviae 2 ~ 4 parts, Semen Lablab Album 4 ~ 6 parts, the Rhizoma Atractylodis Macrocephalae 2 ~ 5 parts, 4 ~ 6 parts of Fructus Jujubae, Arillus Longan 5 ~ 8 parts, Fructus Lycii
Son 4 ~ 6 parts, Radix Codonopsis 2 ~ 3 parts, Semen Juglandis 6 ~ 10 parts, Semen Sesami Nigrum 4 ~ 6 parts, 4 ~ 6 parts of Tremella, 4 ~ 5 parts of Lentinus Edodes, 6 ~ 8 parts of Pericarpium Zanthoxyli,
Semen Canavaliae 1.6 ~ 2.4 parts, Rhizoma Zingiberis 6 ~ 8 parts, 3 ~ 4 parts of aminoacid.
Described a kind of Chinese medicine composition improving immunity, component and each constituent mass number are as follows: Caulis et Folium Brassicae capitatae 7 parts,
10 parts of Fructus Mori, Radix Saposhnikoviae 3 parts, Semen Lablab Album 5 parts, the Rhizoma Atractylodis Macrocephalae 4 parts, 5 parts of Fructus Jujubae, Arillus Longan 6 parts, Fructus Lycii 5 parts, Radix Codonopsis 2.5
Part, Semen Juglandis 8 parts, Semen Sesami Nigrum 5 parts, 5 parts of Tremella, 4.5 parts of Lentinus Edodes, 7 parts of Pericarpium Zanthoxyli, Semen Canavaliae 2 parts, Rhizoma Zingiberis 7 parts, aminoacid 3.5
Part.
The application in the medicine or health product of preparation raising immunity of the described Chinese medicine composition.
The Chinese medicine composition improving immunity is made the agent on any one pharmaceutics with customary adjuvant and/or additive
Type.
Chinese medicine composition and the customary adjuvant and/or additive that improve immunity are made any one health promoting beverage or
Health food.
Raw material described in the formula of the present invention all can buy in market.Composition described above is by weight as proportioning
, can increase according to corresponding proportion when producing or reduce, as large-scale production can by kilogram in units of, or with ton as list
Position, small-scale production can also milligram be unit, and weight can increase or reduce, but the raw medicinal herbs weight between each composition is joined
The constant rate of ratio.
The Chinese medicine preparation of the present invention, is that the raw material of Chinese medicine by being formed by above-mentioned formula adds through extraction or other modes
Work, makes pharmaceutically active substance, subsequently, with this material as raw material, adds pharmaceutically acceptable carrier, according to galenic pharmacy when needing
Routine techniques make.Described active substance can obtain by extracting raw material of Chinese medicine respectively, it is also possible to is extracted by common
Raw material of Chinese medicine obtains, it is also possible to obtain by other means, such as: by pulverizing, squeeze, calcine, grind, sieving, percolation, extraction
Take, water carries, alcohol extraction, ester carries, the method such as ketone carries, chromatography obtains, these active substances can be to be the material of extractum form, Ke Yishi
Dry extract can also be fluid extract, determines to make different concentration according to different needs of preparation.
The compositions of the present invention, its pharmaceutically active substance prepares through extracting processing, and processing can use above-mentioned side
Any combination in method.
Beneficial effect
The Chinese medicine composition of the raising immunity that the present invention provides, selects the material of integration of edible and medicinal herbs, not only has raising immunity
Effect, and without any side effects, use safety, can be directly as food consumption, in season alternation or temperature in spring
Eat during change, the sickness rate of the diseases such as influenza can be greatly reduced, at the edible disease cycle that can shorten of period of disease, when quickening is cured
Between.
Detailed description of the invention
Each component employed in following example all can obtain from common commercial approach.
Embodiment 1
A kind of Chinese medicine composition improving immunity, component and each constituent mass number are as follows: Caulis et Folium Brassicae capitatae 5 parts, 5 parts of Fructus Mori, anti-
Wind 1 part, Semen Lablab Album 3 parts, the Rhizoma Atractylodis Macrocephalae 1 part, 3 parts of Fructus Jujubae, Arillus Longan 3 parts, Fructus Lycii 2 parts, Radix Codonopsis 1 part, Semen Juglandis 4 parts is black
Semen Sesami 3 parts, 2 parts of Tremella, 3 parts of Lentinus Edodes, 5 parts of Pericarpium Zanthoxyli, Semen Canavaliae 1 part, Rhizoma Zingiberis 5 parts, amino acid aspartic acid 2 parts.
Embodiment 2
A kind of Chinese medicine composition improving immunity, component and each constituent mass number are as follows: Caulis et Folium Brassicae capitatae 10 parts, 15 parts of Fructus Mori,
Radix Saposhnikoviae 6 parts, Semen Lablab Album 8 parts, the Rhizoma Atractylodis Macrocephalae 6 parts, 7 parts of Fructus Jujubae, Arillus Longan 10 parts, Fructus Lycii 8 parts, Radix Codonopsis 4 parts, Semen Juglandis 12
Part, Semen Sesami Nigrum 8 parts, 8 parts of Tremella, 6 parts of Lentinus Edodes, 10 parts of Pericarpium Zanthoxyli, Semen Canavaliae 3 parts, Rhizoma Zingiberis 10 parts, amino acid aspartic acid 5 parts.
Embodiment 3
A kind of Chinese medicine composition improving immunity, component and each constituent mass number are as follows: Caulis et Folium Brassicae capitatae 6 parts, 8 parts of Fructus Mori, anti-
Wind 2 parts, Semen Lablab Album 4 parts, the Rhizoma Atractylodis Macrocephalae 2 parts, 4 parts of Fructus Jujubae, Arillus Longan 5 parts, Fructus Lycii 4 parts, Radix Codonopsis 2 parts, Semen Juglandis 6 parts is black
Semen Sesami 4 parts, 4 parts of Tremella, 4 parts of Lentinus Edodes, 6 parts of Pericarpium Zanthoxyli, Semen Canavaliae 1.6 parts, Rhizoma Zingiberis 6 parts, amino acids glutamic acid 3 parts.
Embodiment 4
A kind of Chinese medicine composition improving immunity, component and each constituent mass number are as follows: Caulis et Folium Brassicae capitatae 8 parts, 12 parts of Fructus Mori,
Radix Saposhnikoviae 4 parts, Semen Lablab Album 6 parts, the Rhizoma Atractylodis Macrocephalae 5 parts, 6 parts of Fructus Jujubae, Arillus Longan 8 parts, Fructus Lycii 6 parts, Radix Codonopsis 3 parts, Semen Juglandis 10 parts,
Semen Sesami Nigrum 6 parts, 6 parts of Tremella, 5 parts of Lentinus Edodes, 8 parts of Pericarpium Zanthoxyli, Semen Canavaliae 2.4 parts, Rhizoma Zingiberis 8 parts, amino acid aspartic acid 4 parts.
Embodiment 5
A kind of Chinese medicine composition improving immunity, component and each constituent mass number are as follows: Caulis et Folium Brassicae capitatae 7 parts, 10 parts of Fructus Mori,
Radix Saposhnikoviae 3 parts, Semen Lablab Album 5 parts, the Rhizoma Atractylodis Macrocephalae 4 parts, 5 parts of Fructus Jujubae, Arillus Longan 6 parts, Fructus Lycii 5 parts, Radix Codonopsis 2.5 parts, Semen Juglandis 8
Part, Semen Sesami Nigrum 5 parts, 5 parts of Tremella, 4.5 parts of Lentinus Edodes, 7 parts of Pericarpium Zanthoxyli, Semen Canavaliae 2 parts, Rhizoma Zingiberis 7 parts, amino acid aspartic acid 3.5
Part.
The preparation method of the Chinese medicine preparation of above-mentioned heat-clearing and toxic substances removing: remove the impurity in Chinese medicine and dust, weighs each in proportion
Chinese medicinal components be washed with deionized water clean after, soak about one hour with distilled water, the water yield is advisable there just not to be medium-height grass.By Chinese herbal medicine
Proceeding to together with soak in marmite, big fire is boiled, and goes to slow fire after boiling, reheats 30min.Four layers of filtered through gauze, by water
Boil liquid to pour in beaker.Retaining medicinal residues, add appropriate distilled water in marmite, big fire is boiled, and goes to slow fire, then add after boiling
Hot 30min.Four layers of filtered through gauze, pour into water cooking liquid in beaker, merge with primary water cooking liquid, add aminoacid, stirring
Uniformly, after ordinary filter paper filters, water cooking liquid is concentrated into 100ml.Save backup in-4 DEG C after subpackage labelling.Use front use
The micropore filter of 0.22um filters.
Comparative example 1
Improve immunity Chinese medicine composition, component and proportioning with embodiment 5, differ only in without Caulis et Folium Brassicae capitatae, Fructus Mori and
Radix Saposhnikoviae.
Comparative example 2
Improve immunity Chinese medicine composition, component and proportioning with embodiment 5, differ only in without Arillus Longan, Radix Codonopsis and
Lentinus Edodes.
Laboratory animal and packet
BALB/c mouse (4 ~ 6 weeks ages, body weight 18 ~ 22g), male and female half and half, purchased from Zhejiang Province's Experimental Animal Center.
It is randomly divided into 8 groups, often group 20.Group I is blank group, ND oil-emulsion inactivated vaccine chest muscle injection (0.3ml/
Only);2nd ~ 9 group is embodiment 1 ~ 5 and reference examples 1 ~ 2 medicine group, every day every 10mL/kg body weight), even feed 6d, chest muscle is injected
ND oil-emulsion inactivated vaccine (0.3ml/ is only).Sub-cage rearing, observes the situations such as mice health.During 21 age in days, head exempts from, the 42nd age in days
Time two exempt from.
Blood sampling separates out serum and surveys antibody
After within after before head exempts from, 1d and head exempts from respectively 1 week, 2 weeks and two, exempting from 1 week, 2 weeks, often group randomly drawed 6 chickens, vein under the wing
Blood sampling, separates out serum.Measuring antibody titres to newcastle disease virus with β mono-blood clotting Inhibition test (HI), seek the meansigma methods often organized, result is with X
X log2 represents.Antibody is measured with blood clotting Inhibition test (HI).
Body weight, spleen and the mensuration of fabricius bursa weight
During off-test (8 week old), often group randomly draws 6 mices, and after weighing on an empty stomach, blood-letting is lethal, careful taking-up spleen and method
Family name's capsule.Blotting bloodstain and surface moisture with filter paper, weigh spleen and fabricius bursa weight respectively, often group obtains meansigma methods.The results are shown in Table 1
With table 2.
Different time ND-HI serum antibody titer respectively organized by table 1
| Group | Head exempts from front 1d | Head exempts from latter 1 week | Head exempts from latter 2 weeks | Two exempt from latter 1 week | Two exempt from latter 2 weeks |
| Matched group | 3.0±0.12 | 4.1±0.08 | 5.2±0.11 | 7.4±0.16 | 7.8±0.07 |
| Embodiment 1 | 3.1±0.17 | 4.4±0.11 | 6.1±0.12 | 9.4±0.12 | 10.8±0.12 |
| Embodiment 2 | 3.3±0.21 | 4.7±0.11 | 6.3±0.17 | 9.8±0.11 | 11.2±0.17 |
| Embodiment 3 | 3.4±0.16 | 5.4±0.22 | 6.5±0.14 | 9.6±0.12 | 11.3±0.12 |
| Embodiment 4 | 3.6±0.12 | 5.6±0.15 | 7.4±0.15 | 10.3±0.13 | 13.9±0.15 |
| Embodiment 5 | 4.9±0.17 | 6.9±0.12 | 8.1±0.13 | 11.0±0.12 | 15.6±0.21 |
| Comparative example 1 | 3.2±0.13 | 4.2±0.10 | 5.2±0.14 | 7.4±0.13 | 8.8±0.11 |
| Comparative example 2 | 3.3±0.19 | 4.2±0.15 | 5.3±0.12 | 7.0±0.12 | 8.3±0.13 |
Table 2 is respectively organized mouse experiment and is terminated to be body weight, spleen and fabricius bursa weight
| Group | Body weight (g) | Spleen (g) | Fabricius bursa (g) |
| Matched group | 167.0±1.12 | 1.24±0.25 | 2.28±0.13 |
| Embodiment 1 | 184.5±3.17 | 1.35±0.33 | 2.52±0.15 |
| Embodiment 2 | 186.8±3.21 | 1.45±0.43 | 2.85±0.27 |
| Embodiment 3 | 198.5±3.18 | 1.58±0.81 | 3.41±0.15 |
| Embodiment 4 | 219.8±3.02 | 2.08±0.66 | 4.01±0.15 |
| Embodiment 5 | 239.4±1.18 | 3.76±0.27 | 6.38±0.14 |
| Comparative example 1 | 172.4±1.13 | 1.26±0.32 | 2.68±0.19 |
| Comparative example 2 | 171.9±1.19 | 1.28±0.41 | 2.37±0.12 |
The Chinese medicine preparation of result above display embodiment 1 ~ 5 has facilitation to animal body immune organ, and it is right to be mainly manifested in
The increase of the immune organ weight such as the thymus of animal, spleen, fabricius bursa and the antagonism that traumatized animals immune organ weight is alleviated
Effect.Mouse T lymphocyte conversion ratio can be improved, accelerate cellular immune function and grow perfect, promote plasma cell hypertrophy and resist
Body synthesizes, and improves the immunity of body.
Claims (7)
1. the Chinese medicine composition improving immunity, it is characterised in that component and each constituent mass number are as follows: Caulis et Folium Brassicae capitatae 5 ~
10 parts, 5 ~ 15 parts of Fructus Mori, Radix Saposhnikoviae 1 ~ 6 part, Semen Lablab Album 3 ~ 8 parts, the Rhizoma Atractylodis Macrocephalae 1 ~ 6 part, 3 ~ 7 parts of Fructus Jujubae, Arillus Longan 3 ~ 10 parts,
Fructus Lycii 2 ~ 8 parts, Radix Codonopsis 1 ~ 4 part, Semen Juglandis 4 ~ 12 parts, Semen Sesami Nigrum 3 ~ 8 parts, 2 ~ 8 parts of Tremella, 3 ~ 6 parts of Lentinus Edodes, Pericarpium Zanthoxyli 5 ~
10 parts, Semen Canavaliae 1 ~ 3 part, Rhizoma Zingiberis 5 ~ 10 parts, 2 ~ 5 parts of aminoacid.
A kind of Chinese medicine composition improving immunity the most according to claim 1, it is characterised in that described aminoacid is paddy
Propylhomoserin or aspartic acid.
A kind of Chinese medicine composition improving immunity the most according to claim 1, it is characterised in that component and each component matter
Amount number is as follows: Caulis et Folium Brassicae capitatae 6 ~ 8 parts, 8 ~ 12 parts of Fructus Mori, Radix Saposhnikoviae 2 ~ 4 parts, Semen Lablab Album 4 ~ 6 parts, the Rhizoma Atractylodis Macrocephalae 2 ~ 5 parts, Fructus Jujubae 4 ~ 6
Part, Arillus Longan 5 ~ 8 parts, Fructus Lycii 4 ~ 6 parts, Radix Codonopsis 2 ~ 3 parts, Semen Juglandis 6 ~ 10 parts, Semen Sesami Nigrum 4 ~ 6 parts, 4 ~ 6 parts of Tremella is fragrant
4 ~ 5 parts of mushroom, 6 ~ 8 parts of Pericarpium Zanthoxyli, Semen Canavaliae 1.6 ~ 2.4 parts, Rhizoma Zingiberis 6 ~ 8 parts, 3 ~ 4 parts of aminoacid.
A kind of Chinese medicine composition improving immunity the most according to claim 3, it is characterised in that component and each component matter
Amount number is as follows: Caulis et Folium Brassicae capitatae 7 parts, 10 parts of Fructus Mori, Radix Saposhnikoviae 3 parts, Semen Lablab Album 5 parts, the Rhizoma Atractylodis Macrocephalae 4 parts, 5 parts of Fructus Jujubae, Arillus Longan 6
Part, Fructus Lycii 5 parts, Radix Codonopsis 2.5 parts, Semen Juglandis 8 parts, Semen Sesami Nigrum 5 parts, 5 parts of Tremella, 4.5 parts of Lentinus Edodes, 7 parts of Pericarpium Zanthoxyli, Semen Canavaliae 2
Part, Rhizoma Zingiberis 7 parts, 3.5 parts of aminoacid.
5. in Claims 1-4 Chinese medicine composition described in any one in preparation improves the medicine of immunity or health product
Application.
Application the most according to claim 5, it is characterised in that Chinese medicine composition and the customary adjuvant of immunity will be improved
And/or additive makes the dosage form on any one pharmaceutics.
Application the most according to claim 5, it is characterised in that Chinese medicine composition and the customary adjuvant of immunity will be improved
And/or additive makes any one health promoting beverage.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106266686A (en) * | 2016-08-29 | 2017-01-04 | 河南鑫远洋动物药业有限公司 | Improve Chinese medicine preparation and the application thereof of immunity of poultry |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101536780A (en) * | 2009-04-24 | 2009-09-23 | 山东华信制药集团股份有限公司 | Glue tonifying food and health care food |
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2016
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101536780A (en) * | 2009-04-24 | 2009-09-23 | 山东华信制药集团股份有限公司 | Glue tonifying food and health care food |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106266686A (en) * | 2016-08-29 | 2017-01-04 | 河南鑫远洋动物药业有限公司 | Improve Chinese medicine preparation and the application thereof of immunity of poultry |
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