CN105833201A - Application of Qiweidigu capsules to preparation of medicine for treating hemorrhoids - Google Patents
Application of Qiweidigu capsules to preparation of medicine for treating hemorrhoids Download PDFInfo
- Publication number
- CN105833201A CN105833201A CN201610367167.0A CN201610367167A CN105833201A CN 105833201 A CN105833201 A CN 105833201A CN 201610367167 A CN201610367167 A CN 201610367167A CN 105833201 A CN105833201 A CN 105833201A
- Authority
- CN
- China
- Prior art keywords
- hemorrhoid
- application
- capsules
- hemorrhoids
- ground
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/58—Reptiles
- A61K35/586—Turtles; Tortoises, e.g. terrapins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/066—Clavicipitaceae
- A61K36/068—Cordyceps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention provides application of Qiweidigu capsules to the preparation of medicine for treating hemorrhoids and overcomes the technical prejudices in terms of application in the prior art. Clinical tests show that the Qiweidigu capsules are good in curative effect on hemorrhoids and good in curative effect on internal hemorrhoids, external hemorrhoids or mixed hemorrhoids when being used independently, and the total effective rate of the Qiweidigu capsules is 96.67%; a better effect can be achieved when the Qiweidigu capsules are combined with Qingpeng ointment or Mayinglong hemorrhoids suppository during use, the curative effect is evidently higher than that of common treatment medicine, and a good curative effect on the internal hemorrhoids, the external hemorrhoids and the mixed hemorrhoids and the five common symptoms of the hemorrhoids is achieved.
Description
Technical field
The present invention relates to the ground capsule application in preparing medicine for treaching hemorrhoie of a kind of Tibetan medicine seven taste, belong to
Pharmaceutical technology field.
Background technology
Anal and bowel pile is commonly called as hemorrhoid, is the distinctive commonly encountered diseases of the mankind, frequently-occurring disease.According to relevant reconnaissance information
Showing, the sickness rate of anorectal disease is 59.1%, and hemorrhoid account for 87.25% in all anal and intestinal diseases, and
Most commonly seen with internal hemorrhoid the most again, account for the 52.19% of all anal and intestinal diseases.Men and women all can fall ill, with women
Sickness rate be high；Any age all can fall ill, and wherein the people in 20-40 year is the most common, and can be along with
The increase at age and gradually increase the weight of.Its pathogenic factor is a lot of, when sitting, for a long time station, tired etc. makes human body long
Between be in a kind of fixation postures, thus affect blood circulation, make in pelvic cavity internal organs in slow blood flow and abdomen fill
Blood, cause haemorrhoidal vein over filling, varicose, protuberance, wall of vein tension force decline and cause hemorrhoid be morbidity
One of major reason.
Treatment to hemorrhoid at present includes operative treatment and non-operative treatment, and non-operative treatment is divided into again non-medicine
Thing treatment and Drug therapy, Drug therapy mainly has topical therapy: include suppository, unguentum and lotion；
Oral drug therapy: general employing treats cirsoid medicine.
Seven taste ground Tibetan of capsule system proved recipes, perform standard: Chinese patent medicine provincial standard rises national drug mark
Quasi-part (internal medicine qi-blood-body fluid fascicle)；Standard number: WS-10931 (ZD-0931)-2002.Prescription group
Become to have Cortex Lycii, Radix Curcumae, Hirudo, Cordyceps, Fructus Perillae, Carapax Et Plastrum Testudinis (system), Pheretima.It is nourshing Yin and drynsessmoistening prescription,
Disperse blood stasis and dredge collateral.For quenching one's thirst caused by yin deficiency and blood stasis, type Ⅱdiabetes mellitus is shown in above-mentioned patient.
Seven tastes ground capsules are mainly used in blood sugar lowering, and the aspect such as existing document, patent does not all find that it can be used for
The report for the treatment of hemorrhoid or research.
Summary of the invention
It is an object of the invention to provide seven taste ground capsule application in preparing medicine for treaching hemorrhoie.
Seven taste ground capsules record and rise national drug standards part (internal medicine QI and blood in Chinese patent medicine provincial standard
Body fluid fascicle)；Standard number: WS-10931 (ZD-0931)-2002, market is commercially available.
The present invention is achieved through the following technical solutions:
Seven taste ground capsule application in preparing medicine for treaching hemorrhoie.
Preferably, application of the present invention, its usage and dosage is: oral, one time 4, one day 4
Secondary.
Preferably, application of the present invention, refer to seven taste ground capsules and external application drug for haemorrhoid use in conjunction.
Preferably, application of the present invention, refer to seven taste ground capsules and Ma Yinglong ZHICHUAN SHUAN or blue or green roc
Ointment use in conjunction.
Preferably, application of the present invention, extract including according to seven taste ground capsule formula composition preparations
After compositions, make acceptable any preparation on pharmaceutics further.
Preferably, hemorrhoid of the present invention, refer to internal hemorrhoid, external hemorrhoid or mixed hemorrhoid.
Preferably, hemorrhoid of the present invention, refer to pain, edema, pruritus, abjection and/or just
The hemorrhoid of blood.
It is further preferred that hemorrhoid of the present invention, refer to the hemorrhoid with edema and/or pain.
Beneficial effect:
In the application of seven tastes ground capsules, widely known it is nourshing Yin and drynsessmoistening prescription, disperse blood stasis and dredge collateral.For the deficiency of YIN
Quenching one's thirst caused by blood stasis, type Ⅱdiabetes mellitus is shown in above-mentioned patient.
Instant invention overcomes the technology prejudice of above-mentioned application aspect, found by clinical research, seven taste ground bones
Capsule has good curative effect to hemorrhoid, and total effective rate, 96.67%, is significantly higher than conventional medicine,
And five kinds of symptoms that three kinds of hemorrhoid and hemorrhoid are common are all had good curative effect.
Detailed description of the invention
In order to be more fully understood that the essence of the present invention, seven tastes will be further illustrated by clinical experiment below
Ground capsule application in preparing medicine for treaching hemorrhoie.
The ground analgesia of capsule of experimental example 1: seven taste, hemorrhage, anticoagulation experiment
1 material
1.1 samples and reagent
Seven tastes ground capsule (Jin He pharmaceutcal corporation, Ltd, lot number: 20111201)；LIUWEIXIAOZHI PIAN is (expensive
State grass hall Pharmaceutical Co., Ltd, lot number: 20110502)；Glacial acetic acid (Chinese Medicine group Shanghai
Chemical reagents corporation, lot number: 20110709).
1.2 animal
Healthy qualified KM mice 150, ♀ ♂ dual-purpose, weight 18～25g, real by Shandong Traditional Chinese Medicine University
Test animal center and [laboratory animal credit number: SDXK (Shandong) 20070006] is provided.
2 methods
The 2.1 7 taste ground capsule impacts on the mouse hot-plate threshold of pain
50 ♀ mices are divided into 5 groups at random, i.e. model [wait appearance 1% carboxymethyl cellulose (CMC)] group,
LIUWEIXIAOZHI PIAN group (being called for short: XIAOZHI PIAN group, 2.592g/kg) and seven high, medium and low dose of the capsules in taste ground
Amount (16,8,4mg/20g) group (is called for short: high dose group, middle dosage group, low dose group), and ig is administered,
Every day 2 times, administration volume is 0.2ml/10g, continuous 7d.In last be administered after 30,60,90,120min
Measure mice and lick sufficient incubation period (s), as the hot plate threshold of pain (hot plate temperature is 55 DEG C).
The 2.2 7 taste ground capsule impacts on glacial acetic acid induced mice writhing response
50 mices (♀ ♂ hold concurrently half) are divided into 5 groups at random, i.e. model (waiting appearance 1%CMC) group, six
Taste XIAOZHI PIAN (being called for short: XIAOZHI PIAN group, 2.592g/kg) group and the seven taste ground high, medium and low dosage of capsule
(16,8,4mg/20g) group (is called for short: high dose group, middle dosage group, low dose group), and ig is administered,
Every day 2 times, administration volume is 0.2ml/10g, continuous 7d.After last is administered, 60min gives ip in mice 0.6
% glacial acetic acid solution (0.2ml/ is only), the writhing number of times occurred in 15min after record injected in mice.
2.3 7 taste ground capsules are hemorrhage on mice, the impact of clotting time
50 mices (♀ ♂ hold concurrently half) are divided into 5 groups at random, i.e. blank (waiting appearance 1%CMC) group, six
Taste XIAOZHI PIAN (being called for short: XIAOZHI PIAN group, 2.592g/kg) group and the seven taste ground high, medium and low dosage of capsule
(16,8,4mg/20g) group (is called for short: high dose group, middle dosage group, low dose group), and ig is administered,
Every day 2 times, administration volume is 0.2ml/10g, continuous 7d.30min after last is administered, in order to cutting little
Cut off at rat-tail point 0.5cm, timing when blood flows out naturally, suck drop of blood 1 time every 15s filter paper,
Until blood stops naturally, calculate the bleeding time；Meanwhile, by the blood of outflow in microscope slide two ends each 1,
Drop of blood diameter about 5mm, calculates its clotting time with stopwatch, every 30s cleaning pin from drop of blood edge to
In provoke gently 1 time, and observe and provoke with or without the blood streak, from blood sampling to there being the blood streak to provoke only for clotting time.
2.4 statistical method
SPSS17.0 software processes is used to analyze experimental data.Data represent with x ± s.P ＜ 0.05 is difference
Statistically significant.
3 results
The 3.1 7 taste ground capsule impacts on the mouse hot-plate threshold of pain
Compare with model group, upon administration 30,90min seven taste ground capsule high, medium and low dosage group mice
Lick foot all to extend incubation period, i.e. the hot plate threshold of pain is improved, statistically significant (P the ＜ 0.01 or P ＜ of difference
0.05), 60min then only has high dose group notable prolongation (P ＜ 0.05).Capsules can with pointing out seven tastes
Significantly improve the hot plate threshold of pain, have certain analgesic activity.
The ground capsule impact (x ± s, n=10) on the mouse hot-plate threshold of pain of table 1 seven taste
Compare with model group: * P ＜ 0.05, * * P ＜ 0.01
The 3.2 7 taste ground capsule impacts on glacial acetic acid induced mice writhing response
Compare with model group, seven taste ground capsule dosage high, the middle group statistically significant (P of mouse writhing number of times
＞ 0.05), low dose group is reduced trend, points out seven taste ground capsules anti-to glacial acetic acid induced mice writhing
Should there is certain inhibition.
The ground capsule impact (x ± s, n=10) on glacial acetic acid induced mice writhing response of table 2 seven taste
| Group | Dosage, g/kg | Writhing number of times in 15min |
| Model group | —— | 36.64±9.28 |
| XIAOZHI PIAN group | 2.59 | 28.54±10.13 |
| Low dose group | 0.2 | 29.34±11.01 |
| Middle dosage group | 0.4 | 25.45±8.47* |
| High dose group | 0.8 | 24.52±9.83* |
3.3 7 taste ground capsules are hemorrhage on mice, the impact of clotting time
Comparing with blank group, seven taste ground capsule high dose group mice bleeding times and clotting time all have significantly
Shortening (P ＞ 0.05), middle dosage group is reduced significantly effect to the bleeding time, and low dose group is to hemorrhage
Time and clotting time are without obvious effect.Capsules are hemorrhage to mice, clotting time has one to point out seven tastes ground
Reduced short effect.
Table 3 seven taste ground capsule is hemorrhage on mice, the impact (x ± s, n=10) of clotting time
| Group | Dosage, g/kg | Bleeding time, min | Clotting time, s |
| Blank group | —— | 15.64±4.28 | 178.34±33.76 |
| XIAOZHI PIAN group | 2.59 | 17.54±5.13 | 170.71±29.58 |
| Low dose group | 0.2 | 15.34±5.01 | 172.66±37.23 |
| Middle dosage group | 0.4 | 12.45±4.47* | 160.41±33.18 |
| High dose group | 0.8 | 11.52±5.83* | 150.21±28.73* |
4, brief summary
Test result indicate that, basic, normal, high dosage group seven taste ground capsule causes for the hot plate of experiment mice
Pain reaction all have remarkable result, pain reaction that middle and high dosage group then causes for glacial acetic acid and little
There is remarkable result in the Mus bleeding time, and for clotting time, only high dose group has remarkable result.Seven tastes are described
Ground capsule has certain analgesia, hemorrhage effect.
Experimental example 2: clinical experiment
1 data and method
1.1 physical data
1.1.1 inclusive criteria
Select patient 131 example being chief complaint with hemorrhoid." the traditional Chinese medical science anus issued according to State Administration of Traditional Chinese Medicine
Intestinal section Illnesses Diagnoses criterion of therapeutical effect ", draft with reference to " China anorectal disease ", observe disease and plant as internal hemorrhoid, outward
Hemorrhoid, mixed hemorrhoid.131 patients are randomly divided into 4 groups.4 groups equal at sex, age, sick kind and syndrome integral
Without marked difference, there is comparability, be shown in Table 4.
Table 4 patient's basic document
1.1.1 exclusion standard
Connective tissue external hemorrhoid, gestation and women breast-feeding their children, suffer from the important organ diseases such as serious heart and brain Liver and kidney
Sick, psychotic, suffers from anal fistula, proctoptosis, rectal polyp, anal papilla tumor, colorectal carcinoma, knot
Other anal and intestinal disease such as enteritis, or meet above-mentioned inclusive criteria but the person that needs operative treatment.
1.2 method
After patient signs Informed Consent Form, it is administered respectively:
Matched group: LIUWEIXIAOZHI PIAN (Guizhou Qingcaotang Pharmaceutical Co., Ltd., lot number: 20110502)
Treatment group: seven tastes ground capsule (gold scolds Tibetan medicine, lot number 20130617)
Combine I group: seven tastes ground capsule+Ma Yinglong ZHICHUAN SHUAN (Wuhan Ma Yinglong Pharmaceutical Group Co., Ltd,
Lot number 120425)
Combine II group: seven tastes ground capsule+green grass or young crops roc ointment (gold scolds Tibetan medicine, lot number 20120822)
Each by specification method uses, and 14 days courses for the treatment of, treats 3 courses for the treatment of.Take off without case during treatment
Visit, also do not find obvious adverse reaction.
2 observation index (symptom) and scoring criterion
2.1 pain
0 point: without obvious pain
2 points: slight, intermittent uncomfortable pain
4 points: pain moderate, regular, can tolerate
6 points: serious, rest pain, it is difficult to stand
2.2 edema
0 point: without edema
2 points: single edema, edematous tissue≤1cm
4 points: edema is one or more, symptom is relatively light, edematous tissue≤2cm
6 points: edema is one or more, symptom is heavier, edematous tissue ＞ 2cm
2.3 pruritus
0 point: without pruritus
2 points: pruritus once in a while, do not affect daily life
4 points: pruritus is obvious, often scratches, affects daily life
6 points: pruritus is heavier, have a strong impact on daily life
2.4 abjection
0 point: without abjection
2 points: can the most also receive after blood stasis abjection after an action of the bowels
4 points: need external force also to receive after blood stasis abjection after an action of the bowels
6 points: blood stasis incarceration, it is impossible to also receive
2.5 have blood in stool
0 point: without having blood in stool
2 points: even have toilet paper to have blood in stool
4 points: bleed after an action of the bowels, can stop voluntarily after an action of the bowels
6 points: just before or after an action of the bowels spurting hemorrhage
3, curative effect determinate standard: with reference to " traditional Chinese medical science anorectum department Illnesses Diagnoses criterion of therapeutical effect ", be divided into
Cure: the symptoms such as nothing is had blood in stool, abjection, blood stasis disappears or atrophy completely
Effective: the symptoms such as nothing is had blood in stool, abjection, blood stasis reduces or atrophy is original 1/3
Taking a turn for the better: have after an action of the bowels and have blood in stool on a small quantity or occasionally have blood in stool, companion's blood stasis is slightly deviate from, and blood stasis reduces or withers
It is condensed to original 2/3
Invalid: Sx is without improving or increasing the weight of
4, disease integration criterion of therapeutical effect
With treatment Patients Before And After pain, edema, pruritus, the score value percentage change deviating from and have blood in stool
(therapeutic index) is passed judgment on, therapeutic index (TI)=(integration after integration-treatment before treatment) ÷ treatment
Front integration × 100%
Cure: >=85%
Effective: >=50%
Take a turn for the better: >=20%
Invalid: ＜ 20%
5, statistical method
Ranked data Ridit analyzes, and mean data, enumeration data use u-test, rank test.
6, result
The general curative effect of 6.1 pairs of three kinds of hemorrhoid: be shown in Table 5 and table 6.
On general curative effect, treatment group and 2 drug combination groups are all significantly better than matched group, and seven tastes ground osseocolla
The blue or green roc ointment (combining II group) of capsule associating is better.
Showing the curative effect of three kinds of hemorrhoid, treatment group and 2 drug combination groups are all significantly better than matched group, and
The seven taste ground blue or green roc ointment (combining II group) of capsule associating treat the better of internal hemorrhoid.
Contrast for symptom score shows, seven taste ground capsules are used alone for deviating from edema without aobvious
Write curative effect, combine blue or green roc ointment or associating Ma Yinglong ZHICHUAN SHUAN uses and then has significant curative effect；Seven taste ground bones
Capsule roc ointment the most alone or in combination or associating Ma Yinglong ZHICHUAN SHUAN use for pain and effect of having blood in stool
More preferably；The general effect that seven taste ground capsule associating roc ointment or associating Ma Yinglong ZHICHUAN SHUAN use is the best
In being used alone.
The table 5 Comparison of therapeutic to three kinds of hemorrhoid: total effects
| Case load | Recovery from illness | Effective | Take a turn for the better | Invalid | Total effective (%) | U value | Difference | |
| Matched group | 32 | 3 | 12 | 13 | 4 | 87.50% | —— | —— |
| Treatment group | 33 | 7 | 17 | 6 | 3 | 90.91% | 1.989 | P ＜ 0.05# |
| Combine I group | 33 | 7 | 16 | 9 | 1 | 96.97% | 2.048 | P ＜ 0.05# |
| Combine II group | 33 | 8 | 18 | 6 | 1 | 96.97% | 2.663 | P ＜ 0.01## |
Ridit analyzes: compare with matched group, #P ＜ 0.05 (u >=1.96), ##P ＜ 0.01 (u >=2.58)
The table 6 Comparison of therapeutic to three kinds of hemorrhoid: number
Ridit analyzes: compare with matched group, #P ＜ 0.05 (u >=1.96), ##P ＜ 0.01 (u >=2.58)
The curative effect of 6.2 pairs of different symptoms indexs: be shown in Table 7.
The table 7 curative effect to different symptoms Score index
In upper table, mean scores=∑ (score value × this score value number)/total number of persons
Rank test: compare before being administered, * P ＜ 0.05, * * P ＜ 0.01
Following example all can realize the effect of above-mentioned experimental example.The seven taste ground capsules that embodiment is used
The product that Tibetan medicine Pharmaceutical limited company produces is scolded for Qinghai gold.
The ground capsule application in preparing medicine for treaching hemorrhoie of embodiment 1, seven taste
For internal hemorrhoid.Usage and dosage is: oral, one time 4,4 times on the one.
The ground capsule application in preparing medicine for treaching hemorrhoie of embodiment 2, seven taste
For external hemorrhoid.Usage and dosage is: oral, one time 4,4 times on the one.
The ground capsule application in preparing medicine for treaching hemorrhoie of embodiment 3, seven taste
For mixed hemorrhoid.Usage and dosage is: oral, one time 4,4 times on the one.
The ground capsule application in preparing medicine for treaching hemorrhoie of embodiment 4, seven taste
The blue or green roc ointment of associating uses, for internal hemorrhoid with pain.
Blue or green roc ointment: external, is applied to affected part in right amount, 2 times on the one；
Seven tastes ground capsules: oral, one time 4,4 times on the one.
The ground capsule application in preparing medicine for treaching hemorrhoie of embodiment 5, seven taste
The blue or green roc ointment of associating uses, for internal hemorrhoid with having blood in stool.
Blue or green roc ointment: external, is applied to affected part in right amount, 2 times on the one；
Seven tastes ground capsules: oral, one time 4,4 times on the one.
The ground capsule application in preparing medicine for treaching hemorrhoie of embodiment 6, seven taste
The blue or green roc ointment of associating uses, for internal hemorrhoid with edema.
Blue or green roc ointment: external, is applied to affected part in right amount, 2 times on the one；
Seven tastes ground capsules: oral, one time 4,4 times on the one.
The ground capsule application in preparing medicine for treaching hemorrhoie of embodiment 7, seven taste
The blue or green roc ointment of associating uses, for internal hemorrhoid with pruritus.
Blue or green roc ointment: external, is applied to affected part in right amount, 2 times on the one；
Seven tastes ground capsules: oral, one time 4,4 times on the one.
The ground capsule application in preparing medicine for treaching hemorrhoie of embodiment 8, seven taste
The blue or green roc ointment of associating uses, for external hemorrhoid with having blood in stool.
Blue or green roc ointment: external, is applied to affected part in right amount, 2 times on the one；
Seven tastes ground capsules: oral, one time 4,4 times on the one.
The ground capsule application in preparing medicine for treaching hemorrhoie of embodiment 9, seven taste
The blue or green roc ointment of associating uses, for mixed hemorrhoid with pain.
Blue or green roc ointment: external, is applied to affected part in right amount, 2 times on the one；
Seven tastes ground capsules: oral, one time 4,4 times on the one.
The ground capsule application in preparing medicine for treaching hemorrhoie of embodiment 10, seven taste
Associating Ma Yinglong ZHICHUAN SHUAN uses, for external hemorrhoid with pain.
Ma Yinglong ZHICHUAN SHUAN: sooner or later or greatly fill in anal after an action of the bowels, one time 1,2 times on the one；
Seven tastes ground capsules: oral, one time 4,4 times on the one.
The ground capsule application in preparing medicine for treaching hemorrhoie of embodiment 11, seven taste
Associating Ma Yinglong ZHICHUAN SHUAN uses, and has blood in stool with pain for mixed hemorrhoid.
Ma Yinglong ZHICHUAN SHUAN: sooner or later or greatly fill in anal after an action of the bowels, one time 1,2 times on the one；
Seven tastes ground capsules: oral, one time 4,4 times on the one.
Claims (10)
1. seven taste ground capsule application in preparing medicine for treaching hemorrhoie.
Application the most according to claim 1, it is characterised in that seven taste ground capsules join with external application drug for haemorrhoid
Close application.
Application the most according to claim 2, it is characterised in that described external application drug for haemorrhoid is Ma Yinglong hemorrhoid
Skin ulcer bolt or blue or green roc ointment.
4. according to the application described in any one of claim 1-3, it is characterised in that join according to seven taste ground capsules
After extract is prepared by side, make acceptable any preparation on pharmaceutics further.
5. according to the arbitrary described application of claim 1-3, it is characterised in that described hemorrhoid refer to internal hemorrhoid,
External hemorrhoid or mixed hemorrhoid.
Application the most according to claim 5, it is characterised in that described hemorrhoid, refer to pain,
Edema, pruritus, the hemorrhoid deviating from and/or have blood in stool.
Application the most according to claim 5, it is characterised in that described hemorrhoid refer to edema and/or
The hemorrhoid of pain.
Application the most according to claim 4, it is characterised in that described hemorrhoid refer to internal hemorrhoid, external hemorrhoid or
Mixed hemorrhoid.
Application the most according to claim 8, it is characterised in that described hemorrhoid, refer to pain,
Edema, pruritus, the hemorrhoid deviating from and/or have blood in stool.
Application the most according to claim 8, it is characterised in that described hemorrhoid refer to edema and/or pain
The hemorrhoid of pain.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610367167.0A CN105833201A (en) | 2016-05-27 | 2016-05-27 | Application of Qiweidigu capsules to preparation of medicine for treating hemorrhoids |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610367167.0A CN105833201A (en) | 2016-05-27 | 2016-05-27 | Application of Qiweidigu capsules to preparation of medicine for treating hemorrhoids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105833201A true CN105833201A (en) | 2016-08-10 |
Family
ID=56594983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610367167.0A Pending CN105833201A (en) | 2016-05-27 | 2016-05-27 | Application of Qiweidigu capsules to preparation of medicine for treating hemorrhoids |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105833201A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1106281A (en) * | 1994-04-29 | 1995-08-09 | 于俊英 | Chinese medicinal preparation for treatment of ulcer |
| CN1528378A (en) * | 2003-09-30 | 2004-09-15 | 杨中文 | Chinese medicine for treating haemorrhoids and astriction |
| CN103919940A (en) * | 2014-04-17 | 2014-07-16 | 向芳兰 | Chinese medicinal composition for treating hemorrhoid |
| CN103933410A (en) * | 2013-01-21 | 2014-07-23 | 鲁南制药集团股份有限公司 | Medicinal use and preparation method of traditional Chinese medicine composition |
| CN105012533A (en) * | 2015-08-24 | 2015-11-04 | 张德生 | Traditional Chinese medicine preparation for treating hemorrhoids |
| CN105194135A (en) * | 2015-10-30 | 2015-12-30 | 叶祥生 | Hemorrhoids ointment, preparation method and application of hemorrhoids ointment |
-
2016
- 2016-05-27 CN CN201610367167.0A patent/CN105833201A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1106281A (en) * | 1994-04-29 | 1995-08-09 | 于俊英 | Chinese medicinal preparation for treatment of ulcer |
| CN1528378A (en) * | 2003-09-30 | 2004-09-15 | 杨中文 | Chinese medicine for treating haemorrhoids and astriction |
| CN103933410A (en) * | 2013-01-21 | 2014-07-23 | 鲁南制药集团股份有限公司 | Medicinal use and preparation method of traditional Chinese medicine composition |
| CN103919940A (en) * | 2014-04-17 | 2014-07-16 | 向芳兰 | Chinese medicinal composition for treating hemorrhoid |
| CN105012533A (en) * | 2015-08-24 | 2015-11-04 | 张德生 | Traditional Chinese medicine preparation for treating hemorrhoids |
| CN105194135A (en) * | 2015-10-30 | 2015-12-30 | 叶祥生 | Hemorrhoids ointment, preparation method and application of hemorrhoids ointment |
Non-Patent Citations (5)
| Title |
|---|
| 中华人民共和国国家药品监督管理局: "《国家药品标准-内科气血津液分册》", 31 December 2002 * |
| 华明义、李体金、马平义: "《糖尿病诊治新概念》", 31 October 2002, 中国物资出版社 * |
| 徐元贞等: "《中华方药宝典》", 30 April 2012, 河南科学技术出版社 * |
| 徐廷翰、欧亚龙: "《中西医结合大肠肛门病研究新进展》", 31 October 2004, 四川科学技术出版社 * |
| 白寿宁等: "《宁夏枸杞研究 下册》", 31 December 1999, 宁夏人民出版社 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103463539B (en) | A kind of medicine for the treatment of eczema and its production and use | |
| CN102205107B (en) | Chinese medicinal preparation for treating duodenal ulcer and preparation method thereof | |
| CN103341092B (en) | Preparation method of powder for treating atrophic vaginitis | |
| CN103705796B (en) | A kind of pharmaceutical composition for the treatment of diarrhoea and preparation method thereof | |
| CN103735620B (en) | A kind of nano-emulsion in-situ gel treating hemorrhoid | |
| CN103285284B (en) | Medical composition for treating senile vaginitis | |
| CN103301353B (en) | Pharmaceutical composition for treating atrophic vaginitis | |
| CN103356932B (en) | A kind of pharmaceutical composition for the treatment of vulva squamous epithelial hyperplasia | |
| CN103301373B (en) | Pharmaceutical composition for treating postpartum perineal mucosal lesions | |
| CN103191399A (en) | Traditional Chinese medicine composition for treating bronchial asthma in acute-outbreak period | |
| CN103330867B (en) | Preparation method of powder for treating senile vaginitis | |
| CN103157050B (en) | Traditional Chinese medicine composition for treating vulvar itching diseases and preparation method thereof | |
| CN103479968B (en) | Traditional Chinese medicine composition for treating heart-fire flaming acne | |
| CN105833201A (en) | Application of Qiweidigu capsules to preparation of medicine for treating hemorrhoids | |
| CN105497262A (en) | Medicine composition for treating liver-yin and kidney-yin deficiency type polycystic ovarian syndrome | |
| CN103316270B (en) | Preparation method of powder of medicine for treating postnatal perineum mucosal lesion | |
| CN104352586B (en) | Blue or green roc ointment application in preparing medicine for treaching hemorrhoie | |
| CN103341094B (en) | Preparation method of powder for treating vulva squamous epithelial cell hyperplasia | |
| CN103301388B (en) | Traditional Chinese medicine composition for treating chronic gastrointestinal inflammation | |
| CN109925426A (en) | A kind of herbal fumigation agent can treat hemorrhoid | |
| CN103316258B (en) | Medicine composition for treating infantile vaginitis | |
| CN103301354B (en) | Preparation method of powder for treating infantile vaginitis | |
| CN105233180A (en) | Drug for treating internal hemorrhoid due to damp-heat pouring downward syndrome | |
| CN105288016B (en) | External traditional Chinese medicine emulsion for preventing and treating knee osteoarthritis and preparation method thereof | |
| CN105435162A (en) | Traditional Chinese medicine composition for treating allergic rhinitis, preparation method and traditional Chinese medicine preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160810 |