CN105833170A

CN105833170A - Medicine composition for clinically nursing peptic ulcer

Info

Publication number: CN105833170A
Application number: CN201610193363.0A
Authority: CN
Inventors: 杨海林; 刘学键
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-03-30
Filing date: 2016-03-30
Publication date: 2016-08-10

Abstract

The invention relates to a medicine composition for clinically nursing peptic ulcer. The medicine composition is prepared from the following ingredients of herba houttuyniae, dandelion, radix cirsii jeponici, coix seeds, Chinese yam, rhizoma cyperi, wheat germ, endothelium corneum gigeriae galli, rhizoma coptidis, radix salviae miltiorrhizae, chaff flower roots, radix linderae, frankincense, rhizoma cimicifugae, rhizoma ligustici wallichii, cortex moutan, glossy privet fruit, trichosanthes, iphigenia indica, radix paeoniae alba, shell of areca nut, perilla frutescens, pawpaw, radix angelicae pubescentis, agilawood, rhizoma atractylodis and radix curcumae. The medicine composition has the advantages that the effect of treating both symptoms and root causes is achieved; the medicine composition is poisonless and harmless to human bodies; no side effect exists; the price is low; the manufacturing is simple and convenient; and the application prospects are wide.

Description

The pharmaceutical composition of clinical care peptic ulcer

Technical field

The invention belongs to technical field of pharmaceuticals, be specifically related to the pharmaceutical composition for clinical care peptic ulcer with Chinese herbal medicine as raw material.

Background technology

Peptic ulcer refers mainly to betide the duodenal chronic ulcer of harmonization of the stomach, is a frequently-occurring disease, commonly encountered diseases.Ulcer be formed with various factors, wherein acidic gastric juice is the Fundamentals of ulcer to the Digestion of mucosa, hence obtains one's name.Any position of acidic gastric juice contact, such as distal esophagus, the postoperative anastomotic stoma of gastrointestinal anastomosis, jejunum and the Meckel diverticulum with Ectopic Gastric Mucosa, most of ulcer betides duodenum stomach function regulating, therefore also known as taste-blindness rate.Why it is referred to as peptic ulcer, it is because previously thinking that mucosa autodigestion is formed by peptic ulcer and duodenal ulcer due to gastric acid and pepsin, in fact gastric acid and pepsin are the one of the main reasons of ulcer, and also other reasons can form peptic ulcer.Owing to peptic ulcer and the cause of disease of duodenal ulcer and clinical symptoms have many similarities, sometimes it is difficult to differentiate between peptic ulcer or duodenal ulcer, is the most often diagnosed as peptic ulcer, or taste-blindness rate.If the clear and definite ulcer of energy is at stomach or duodenum, that just can directly be diagnosed as peptic ulcer or duodenal ulcer.

Irregular recently as the quickening of rhythm of life and diet, peptic ulcer rate rises year by year.Its cardinal symptom is often the rhythmicity epigastrium pain of recurrent exerbation or the chronic arythmia pain of middle upper abdomen, often accompany acid regurgitation, glutted, belch, scorching hot, noisy etc., even Nausea and vomiting, hematemesis, having blood in stool, minority can be developed to gastric cancer, serious threat patient vitals.Peptic ulcer main pathogenic has: 1. helicobacter pylori (Hp): Hp is a kind of gastrointestinal pathogen, containing VacA (VacA) and cell toxicant related gene A (CagA) in its strain drive member, it it is the Important cause of disease in peptic ulcer generating process.2. gastric acid: hyperchlorhydria can cause peptic ulcer, is also unfavorable for ulcer healing simultaneously.Gastric acid and pepsin directly act on unprotected gastric mucosa, can cause gastric mucosa corrosion and digestion.3. gastrin: gastrin can promote the secretion of gastric acid and pepsinogen, increases the weight of the erosion to gastric mucosa.4. free radical: when body is by virus and bacterial invasion, immunocyte is produced from by substrates matter, mainly oxygen-derived free radicals, kills bacterial virus as mean of defense.But under some pathologic condition, it produces and removes the possible disequilibrium of function so that it is accumulation too much causes damage in the tissue.Oxygen-derived free radicals is combined with polyvalent unsaturated fatty acid, can produce the lipid peroxide such as MDA, destroys lysosome membrane and mitochondrion, causes ulcer.

Peptic ulcer is treated drug toxic and side effects by current Western medicine greatly and has infringement to the Liver and kidney of patient, and relapse rate is the highest after drug withdrawal, motherland's medical science is thought, peptic ulcer belongs to the categories such as " gastric abscess ", " stomachache due to hyperactive liver-QI attacking the stomach ", " pained " of motherland's medical science, " acid regurgitation ".Many referred to as " epigastric pain ", " peratodynia " among the people, " stomachache ", " hungry full consumptive disease " etc..Liver is viscus attriguted to wind and wood, main catharsis, and spleen is the dirty of Zhiyin, and relying the catharsis of liver to begin can post transporting.Edema with the liver involved catharsis then spleen-QI being ascending, spleen precise and tiny on be attributed to lung；And make gastric qi decline, the fluent small intestinal of water paddy become thoroughly decomposed.If the liver failing to maintain the normal flow of QI, wood gas pent-up, then spleen-QI failing to rise up, failure of stomach-QI to descend, stop up stagnant for disease；Or edema with the liver involved takes advantage of it, weakness of the spleen and stomach, or catharsis is too, and taste, by an opposite direction, lift immoderate, then disturbance of QI is disease.Spleen is source of generating QI and blood, the internal organs of taste the exterior and the interior each other.Insufficiency of the spleen then insufficiency of generating and transforming QI and blood, stomach mistake is moistened foster, and ulcer and recurrent exerbation, does not the most easily occur in Rong Ze pain, " prolonged illness people's network, for a long time pain stay the stasis of blood ", the venation of stagnation of blood stasis stomach, and QI-blood circulation is smooth, therefore stagnation of QI and blood may bring about pain；The stasis of blood the most then stomach mistake is moistened foster, the most then gives birth to ulcer.Stagnation of blood stasis is not only the result of peptic ulcer recurrent exerbation, especially its protracted inflammation, refractory difficulty important step more.Therefore stagnation of liver-QI with deficiency of the spleen blood stasis is the main pathology link that peptic ulcer occurs and recurs, soothing liver and strengthening spleen activating blood circulation method is its base therapy rule for the treatment of.Develop a kind of high-efficiency low-toxicity, the Chinese medicine preparation for the treatment of both the principal and secondary aspects of a disease is still clinical eager needs.

Summary of the invention

It is an object of the invention to provide that a kind of side effect is little, the pharmaceutical composition of the clinical care peptic ulcer of safe ready.Its purpose is to solve treatment peptic ulcer, overcome Western medicine toxic and side effects big, the inapparent problem of therapeutic effect, reach the purpose for the treatment of both the principal and secondary aspects of a disease.

Present inventor is from motherland's traditional medicine theory, in constantly clinical research is screened for many years, some medicines chosen prescription, carry out pharmacology, pharmacodynamics and clinical practice etc. are studied, obtaining the pharmaceutical composition of clinical care peptic ulcer of the present invention, this pharmaceutical composition has warming middle-JIAO of regulating the flow of vital energy, pain relieving.Curing mainly the cold syndrome of the stomach syndrome of stagnation of QI of gastric abscess, disease sees that gastral cavilty painful abdominal mass is swollen and pain, poor appetite, the dim gas of acid regurgitation, defecates uncomfortable, pale tongue, white and thin fur, thready and weak pulse or heavy thin.

For achieving the above object, the technical solution used in the present invention is as follows:

The pharmaceutical composition of a kind of clinical care peptic ulcer, it is characterised in that described compositions is prepared by following raw material:

Herba Houttuyniae, Herba Taraxaci, Radix Cirsii Japonici, Semen Coicis, Rhizoma Dioscoreae, Rhizoma Cyperi, Fructus Hordei Germinatus, Endothelium Corneum Gigeriae Galli, Rhizoma Coptidis, Radix Salviae Miltiorrhizae, Radix Achyranthis Bidentatae, the Radix Linderae, Olibanum, Rhizoma Cimicifugae, Rhizoma Chuanxiong, Cortex Moutan, Fructus Ligustri Lucidi, Fructus Trichosanthis, Pseudobulbus Cremastrae Seu Pleiones, the Radix Paeoniae Alba, Pericarpium Arecae, Folium Perillae, Fructus Chaenomelis, Radix Angelicae Pubescentis, Lignum Aquilariae Resinatum, Rhizoma Atractylodis, Radix Curcumae.

Preferably, described pharmaceutical composition, it is prepared by the raw material of following weight proportioning:

Herba Houttuyniae 35 parts, Herba Taraxaci 35 parts, Radix Cirsii Japonici 35 parts, Semen Coicis 35 parts, Rhizoma Dioscoreae 35 parts,

Rhizoma Cyperi 30 parts, 30 parts of Fructus Hordei Germinatus, Endothelium Corneum Gigeriae Galli 30 parts, Rhizoma Coptidis 30 parts, Radix Salviae Miltiorrhizae 27 parts,

Radix Achyranthis Bidentatae 27 parts, the Radix Linderae 27 parts, Olibanum 27 parts, Rhizoma Cimicifugae 25 parts, Rhizoma Chuanxiong 25 parts,

Cortex Moutan 22 parts, Fructus Ligustri Lucidi 22 parts, Fructus Trichosanthis 22 parts, Pseudobulbus Cremastrae Seu Pleiones 20 parts, the Radix Paeoniae Alba 20 parts,

Pericarpium Arecae 20 parts, Folium Perillae 18 parts, Fructus Chaenomelis 15 parts, Radix Angelicae Pubescentis 15 parts, Lignum Aquilariae Resinatum 15 parts,

Rhizoma Atractylodis 10 parts, Radix Curcumae 10 parts.

Medicine of the present invention can add one or more pharmaceutically acceptable carriers and be mixed and made into any one clinically or pharmaceutically acceptable dosage form, preferred oral preparation.When being applied to the patient needing this treatment in the way of oral administration, the solid preparation of routine can be made into, such as tablet, capsule, soft capsule etc..

Preferably, preparation method is:

1) each raw material is weighed, standby；

2) taking Semen Coicis, Rhizoma Dioscoreae, Rhizoma Cyperi, Fructus Hordei Germinatus, Rhizoma Coptidis, the Radix Linderae, Olibanum, Cortex Moutan, Fructus Ligustri Lucidi, the Radix Paeoniae Alba, Fructus Chaenomelis, Lignum Aquilariae Resinatum, Rhizoma Atractylodis mix homogeneously, the water intense fire adding 5 times of weight boils, then slow fire boiling 1 hour, and filtrate and filtering residue are collected by filtration；Adding 2 times of weight water in filtering residue, intense fire boils, and then slow fire boiling 1 hour, is collected by filtration filtrate；Merge twice filtrate, after cooling, be condensed into the extractum that density is 1.2g/ml；After 80 DEG C dry, it is ground into powder, is composite I；

3) take residual components add relative to 3 times of weight 75%(volume fractions of mixture) ethanol, reflux, extract, 2 times, each 1 hour, extracting solution merge, be concentrated into the clear paste that density is 1.2g/ml, 80 DEG C of drying, Complex II is prepared in pulverizing；

4) by composite I and Complex II mixing and stirring, sterilization prepares capsule product.

Usage and dosage, each 0.2g, three times on the one, three weeks be a course for the treatment of.

The present invention is on the basis of the clinical experience of Chinese traditional treatment peptic ulcer, develops pharmaceutical composition in conjunction with modern pharmacy achievement.There is the strongest suppressing the hyperactive liver pain relieving, regulating qi-flowing for strengthening spleen, spleen reinforcing lung kidney, promote the purpose of ulcer healing.

Detailed description of the invention

Embodiment 1

A kind of pharmaceutical composition for clinical care peptic ulcer, it is characterised in that be prepared by the raw material of following weight proportioning:

Rhizoma Atractylodis 10 parts, Radix Curcumae 10 parts.

Preparation method is:

1) each raw material is weighed, standby；

Embodiment 2

Function test

Studies on acute toxicity

Healthy rat and mice single oral gavage respectively gives the pharmaceutical composition for clinical care peptic ulcer of embodiment 1 preparation, and given low is clinical intend consumption 50 times.After administration, mice occurs that light activity reduces, and within about 1 hour, recovers normal, Continuous Observation 7 days after administration, none animal dead, its overall health of patients, diet, take the photograph water, urine and body weight increase all normal, obvious acute toxic reaction does not occurs, does not causes animal dead yet.The reactions such as obvious acute toxic reaction does not occurs in mice, and rat occurs having loose bowels just, activity minimizing, acute toxicity target organ is liver and spleen.Point out this medicine acute toxicity low, clinical drug safety.

Pharmaceutical research

Take healthy rat 60, body weight 180 ± 20g, male and female half and half.Divide 3 groups at random by body weight, sex, first group be embodiment 1 medicine group, second group be ranitidine group, the 3rd group be distilled water matched group.Every day gavage 1 time.After within 3rd week, being administered, water 48h is can't help in fasting.After last is administered 3h, each group rat equal gavage dehydrated alcohol 1.0ml/ only, puts to death after lh, cut open the belly ligation pylorus and cardia.Take stomach and inject Sal water 10ml to gastric, after being placed in 10% formalin fixing, 10min, cutting along greater gastric curvature, wash away gastric residue with normal saline, observe and evaluate ulcer index.Assessment method: gastric gland the length people of streak damage occurs in 1mm person, measures length, and every mm counts 1 point, and its width doubles more than lmm person's score, and length and width are respectively less than lmm, score 0.5 point, and score is added the ulcer index being this Mus.

Result embodiment as shown in table 11 medicine group all has obvious inhibiting effect to rat dehydrated alcohol type peptic ulcer, compares P < 0.0l with matched group.

Table 1 rat dehydrated alcohol type peptic ulcer is tested

Group	Number of cases	Ulcer index
			First group	20	43. 47±8.23
Second group	20	47.68±10.17
			3rd group	20	221.04±10.15

Embodiment 3

1, clinical data

The Peptic Ulcers that 110 examples have complete clinical data is randomly divided into treatment group and matched group, treatment group 55 example, male 20 examples, female 35 example, the course of disease 3 months-7 years.Matched group 55 example, male 19 examples, female 36 example, the course of disease 2 months-7 years, at aspects such as sex, age, the courses of disease without significant difference (P ＞ 0.05) before two groups of case treatments, there is comparability.

2, diagnostic criteria

" the medicine for digestive system guideline of clinical investigations " promulgated for 1993 with reference to Ministry of Public Health, syndrome of heat in the stomach: burning pain in the epigastrium, mouth happiness is thirsty, desire for cold drinks, acid regurgitation.Gingival swelling and pain, dry stool yellowish urine, red tongue with yellow fur.Syndrome of cold in the stomach: stomachache with cool feeling, bitterly gesture are more acute, and trembling with fear, it is light to review, and vomits clear water, and tongue is the thickest.Blood stasis gastric abscess: pain of gastric cavity aching as needle stabbing, fixes and does not moves, tenderness, purplish tongue.Dyspepsia is demonstrate,proved: gastral cavilty distension pain, acid regurgitation, and it is smelly dirty to rush down lower sour, and thick fur is turbid.

Western medicine diagnose standard

(1) periodicity of recurrent exerbation, regular upper abdominal pain.

(2) epigastrium tenderness.

(3) fibergastroscopy display ulcer.

3, Therapeutic Method

(1) treatment group 55 example, the pharmaceutical composition of oral embodiment 1 preparation, each 0.2g, three times on the one, within three weeks, it is a course for the treatment of, takes before the meal in three.

(2) matched group 55 example, uses ranitidine, 1 150mg, and every day twice, three weeks is a course for the treatment of, and gastroscope statistics curative effect is checked in treatment after terminating.

1, criterion of therapeutical effect

(1) recovery from illness

The symptoms such as a, upper abdomen vexed swollen, pain, acid regurgitation, belch eliminate.

B, epigastrium tenderness eliminate；

C, fibergastroscope check display ulcer was wholly absent as the red cicatrix phase.

(2) effective

The symptoms such as a, upper abdomen vexed swollen, pain, acid regurgitation, belch substantially alleviate；

B, epigastrium tenderness are inconspicuous.

C, fibergastroscope check display ulcer disappearance mucosa substantially is concentrated.

(3) effective

The symptoms such as a, upper abdomen vexed swollen, pain, acid regurgitation, belch alleviate；

B, epigastrium tenderness exist；

The routed soup range shorter more than 50% of c, fibergastroscope check display.

(4) invalid

Compare, without any change with before treatment.

Concrete therapeutic outcome such as following table 2:P ＜ 0.05

Table 2

Group	Example time	Recovery from illness	Effective	Effectively	Invalid	Total effective rate (%)
							Treatment group	55	35	9	9	2	96.4
Matched group	55	28	10	7	10	81.8

As seen from the above table: cure rate and the total effective rate for the treatment of group alleviation peptic ulcer are significantly better than that matched group, have significant difference.

Embodiment 4

Bai, man 41 years old.Suffer from peptic ulcer, often feel stomach discomfort.Simultaneously with gastral cavilty portion burning sensation, tending to vomit of feeling sick, acid regurgitation, eat raw and cold and pungent postemphasis.During state of an illness fashion bad.The nearly uncomfortable rear gastralgia of diet increases the weight of.And have vomiting and nausea sense.Gastral cavilty is scorching hot.Belch acid regurgitation, pale tongue, have blood in stool in a large number.The micro-Huang of tongue and greasy, deep and stringy pulse.It is diagnosed as peptic ulcer.Take the pharmaceutical composition of embodiment 1 preparation, three times a day, take before the meal in three.After one course for the treatment of, pain disappears substantially, continues to take a course for the treatment of, barium meal examination, and ulcer surface disappears, the equal nothing of symptom and sign.

Above-mentioned each Chinese medicine and western medicine interaction compatibility that the present invention uses, its collaborative effect of curing the disease can be played, there is between each composition of raw material of Chinese medicine used drug effect be interweaved and mutually promote and coordinate usefulness, according to clinical verification, peptic ulcer is had good therapeutic effect, in the applicant's medical practice for many years, the case Numerous cured, all obtain good effect, and with low cost, alleviate the burden of patient.

Claims

1. the pharmaceutical composition of clinical care peptic ulcer, it is characterised in that be prepared by following raw material:

Pharmaceutical composition the most according to claim 1, it is characterised in that described pharmaceutical composition is prepared by the raw material of following weight proportioning:

Rhizoma Atractylodis 10 parts, Radix Curcumae 10 parts.

3. according to the pharmaceutical composition described in claim 1-2, it is characterised in that the preparation method of described pharmaceutical composition is as follows:

1) each raw material is weighed, standby；

2) taking Semen Coicis, Rhizoma Dioscoreae, Rhizoma Cyperi, Fructus Hordei Germinatus, Rhizoma Coptidis, the Radix Linderae, Olibanum, Cortex Moutan, Fructus Ligustri Lucidi, the Radix Paeoniae Alba, Fructus Chaenomelis, Lignum Aquilariae Resinatum, Rhizoma Atractylodis, mix homogeneously, the water intense fire adding 5 times of weight boils, then slow fire boiling 1 hour, and filtrate and filtering residue are collected by filtration；Adding 2 times of weight water in filtering residue, intense fire boils, and then slow fire boiling 1 hour, is collected by filtration filtrate；Merge twice filtrate, after cooling, be condensed into the extractum that density is 1.2g/ml；After 80 DEG C dry, it is ground into powder, is composite I；

3) surplus stock is taken, mixing, add the ethanol relative to 3 times of weight 75% of mixture, reflux, extract, 2 times, each 1 hour, extracting solution merged, and is concentrated into the clear paste that density is 1.2g/ml, and 80 DEG C of drying, Complex II is prepared in pulverizing；

4) by composite I and Complex II mixing and stirring, sterilization and get final product.

4. compositions described in claim 1-3 is for the purposes of digestive ulcer medicament.