CN105833117A - Traditional Chinese medicine composition for treating rheumatoid arthritis - Google Patents
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Abstract
The invention discloses a traditional Chinese medicine composition for treating rheumatoid arthritis. The traditional Chinese medicine composition is prepared from, by weight, 10-35 parts of radix clematidis, 6-20 parts of radix saposhnikoviae, 6-12 parts of semen brassicae, 10-20 parts of honeysuckle stems, 6-12 parts of prepared stiff silkworms, 3-8 parts of medicinal scorpions, 3-8 parts of centipedes, 6-15 parts of radix angelicae, 10-30 parts of stir-fried coix seeds, 10-25 parts of rhizoma corydalis and 10-25 parts of cortex erythrinae. The basic etiology and pathogenesis of intermingled cold and heat and phlegm stagnation, numbness and obstruction of the rheumatoid arthritis are firstly summarized, the traditional Chinese medicine composition is prepared on the basis of the basic etiology and pathogenesis, and the compatible characteristics of cold-warm combination and simultaneous treatment of phlegm and blood stasis are achieved. When the traditional Chinese medicine composition is used for treating the rheumatoid arthritis, the treatment effect is sure, safety, simpliness and convenience are achieved, the effect-enhancing and toxicity-reducing effects are achieved, symptoms and signs (such as the joint pain degree, the swelling degree, the pressing pain degree, the motion degree, the grip strength and morning stiffness) can be improved, the indexes such as an anti-CCP antibody, an RF, ESR and CRP are improved, the western medicine dosage is decreased, and the illness state relapse rate is decreased.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, be specifically related to a kind of Chinese drug-treated group for treating rheumatoid arthritis
Compound.
Background technology
Rheumatoid arthritis is a systemic autoimmune disease, as Morbidity control is improper, ultimately results in pass
Joint destroys, deformity, and people's health in serious harm, and rheumatoid arthritis is one of difficult problem of puzzlement medical circle.
Rheumatoid arthritis pathogenesis is indefinite, there is no specific treatment means, and clinical efficacy has much room for improvement,
Find that effective medicine has important clinical value.
The Western medicine for the treatment of rheumatoid arthritis has hormone, immunodepressant, biologic product, non-steroidal anti-at present
Scorching antalgesic etc., but the compliance of patient therapy is poor, and compound of Chinese herbal medicine rheumatoid arthritis has advantage.
At present pathogen and pathology of tcm arthritic to rheumatoid arthritis understanding differs, and therapy, choosing side are different.
Western medicine rheumatoid arthritis has certain side effect, the easy recurrent exerbation of the state of an illness, hormone, immunosupress,
The decrements such as non_steroidal anti_inflammatory drug are the most smooth.Treatment by Chinese herbs rheumatoid arthritis toxic and side effect is little, promotes west
Minimizing removed by medicine, stablizes the state of an illness, improves clinical efficacy.
Up to now, not yet have been reported that treatment rheumatoid based on cold-heat jumble, blockage of phlegm and blood stasis etiology and pathogenesis is closed
The Chinese medicine compound prescription that joint is scorching.
Summary of the invention
Goal of the invention: it is an object of the invention to provide a kind of Chinese medicine compound prescription for treating rheumatoid arthritis,
Rheumatoid arthritis can easy, be effectively treated by this Chinese medicine compound prescription.
Technical scheme: it is an object of the invention to be realized by following technical proposals:
A kind of Chinese medicine composition treating rheumatoid arthritis, is made up of the raw material of following parts by weight: Wheeling
Celestial 10～35 parts, windproof 6～20 parts, semen brassicae 6～12 parts, caulis lonicerae 10～20 parts, the stiff silkworm 6 of system～
12 parts, scorpio 3～8 parts, centipede 3～8 parts, the root of Dahurain angelica 6～15 parts, parched rice benevolence 10～30 parts, corydalis tuber
10～25 parts, erythrina bark 10～25 parts.
This invention is based on treatise on Febrile Diseases method of using medicines with both cold and hot natures, in conjunction with clinical practice, sum up cold-heat jumble,
Blockage of phlegm and blood stasis is the Basic disease cause interpretation of the cause, onset and process of an illness of rheumatoid arthritis.
Based on rheumatoid arthritis cold-heat jumble, the blockage of phlegm and blood stasis Basic disease cause interpretation of the cause, onset and process of an illness, establish warming and activating meridian, heat-clearing
Except numbness, dissipating phlegm and removing blood stasis therapy.
Based on above therapy, this Chinese medicine composition is formulated in screening.Windproof in side expel pathogenic wind from the body surface, win wet pain relieving, " this
Grass detailed outline " point out this medicine: " wind as 36, channels and collaterals stay wet, all over the body pain all over the joints.Except wind dries elixir.",
Root of Chinese clematis temperature through dispelling wind and removing obstruction in the meridians, Tang Materia Medica: " waist, kidney, pin knee, accumulation, all cold diseases of enteral, the most not
It is recovered, the effect of clothes." two medicines are monarch drug in a prescription altogether；Semen brassicae heat warm in nature, reduce phlegm dispersing swelling and dissipating binds, and Compendium of Material Medica refers to
Going out this medicine profit gasification phlegm, caulis lonicerae is cold in nature, heat-clearing can remove numbness, " carrying out rock book on Chinese herbal medicine ": " caulis lonicerae controls muscles and bones
Pain.", two medicines share, and heat-clearing removes numbness, and resolving phlegm and dissipating blood stasis, for ministerial drug；The stiff silkworm of system, scorpio, centipede are
The product that flesh and blood is in love, have the merit of swelling and pain relieving, three medicine compatibilities, pick network and search heresy, and root of Dahurain angelica detumescence is removed obstruction in channels to relieve pain,
" book on Chinese herbal medicine converge with speech ": " root of Dahurain angelica, the up head lower support stomach, in reach limbs, all over logical skin so that hair key,
And profit lets out perverse trend.", rice benevolence is cool in nature, and taste is sweet, light, and invigorating the spleen excreting dampness removes numbness, and above five medicines are adjutant altogether；Unit
Recklessly invigorate blood circulation, promoting the circulation of qi, pain relieving, Li Shizhen (1518-1593 A.D.) meaning corydalis tuber: " can the stagnation of the circulation of vital energy in promoting circulation of blood, stasis in gas, therefore specially control all over the body
Upper and lower all pains ", erythrina bark is removed obstruction in channels to relieve pain, Compendium of Material Medica meaning erythrina bark " network of passing through, reaches disease institute ... ",
The merit of the two existing pain relievings of medicine, has again the effect of the through sick institute of tying-in, for making medicine in side.Full side compatibility using medicines of both cold and hot natures simultaneously,
The phlegm stasis of blood is also controlled.
This traditional Chinese medicine composition for treating rheumatoid arthritis has Synergy and attenuation effect, can improve symptom and sign and (close
Joint pain degree, swelling, tenderness degree, mobility, grip, morning are stiff), improve antiCCP antibody, RF, ESR,
The indexs such as CRP, PLT, Ig, reduce Western medicine (MTX, Meloxicam) consumption, reduce disease relapse rate, excellent
In western medicine group.Show that this Chinese medicine compound prescription has the immunoregulation effects such as anti-inflammatory, clinical treatment can be remarkably reinforced
Effect, promotes Western medicine decrement, stablizes state of an illness effect.Have and affect CIA lymphocyte of adjurant arthritis rat gene expression profile effect,
Lower proinflammatory cytokine and stop CIA rat bone to corrode, inducing apoptosis of synoviocytes.May be by lowering
MiRNA-146a expresses, and raises DNA methylation transferase expression and affects miRNA-146a to CIA rat
DNA methylation regulating and controlling effect.
Advantages of the present invention and beneficial effect: 1, take the lead in summing up and proposing rheumatoid arthritis cold-heat jumble, phlegm
The stasis of blood numbness resistance Basic disease cause interpretation of the cause, onset and process of an illness, formulates this Chinese medicine composition based on this；2, this traditional Chinese medicine composition for treating rheumatoid
Arthritis curative effect is certainly, safe and simple；3, this Chinese medicine composition compatible experiments is using medicines of both cold and hot natures simultaneously, and the phlegm stasis of blood is also
Control.
Detailed description of the invention
In order to make the object, technical solutions and advantages of the present invention clearer, below in conjunction with specific embodiment pair
The present invention is described in detail.
Embodiment one:
Raw material: 20 parts of the root of Chinese clematis, windproof 12 parts, semen brassicae 9 parts, caulis lonicerae 12 parts, the stiff silkworm 9 parts of system,
Scorpio 5 parts, centipede 5 parts, the root of Dahurain angelica 9 parts, parched rice benevolence 20 parts, corydalis tuber 12 parts, erythrina bark 12 parts.
Patient, remaining certain, female, 55 years old.Double ankle-joint red and swollen heat pains, left shoulder joint, duplex joint have a pain,
Morning is stiff, and neck is arrested anxious, weak, chilly all over the body, uneasy sleeping at night, and food of receiving is poor, and two just adjust.Examine its dark tongue quality
Red, tongue is thin in vain, examines its thready,rolling and rapid pulse.Look into: ESR45mm/h, CRP10.5mg/l, RF189IU/ml,
AntiCCP antibody 221RU/ml, IgG 16.5g/L.This is asthenia in origin and asthenia in superficiality, cold-heat jumble, blockage of phlegm and blood stasis institute
Cause.Slow fire is boiled medicine 2 times, boils medicine 30 minutes every time, total amount 500ml, every day 1 dose, divides 2 times and is administered orally,
Treat 3 months, look into ESR15mm/h, CRP3.30mg/l, RF27IU/ml, antiCCP antibody 40RU/ml,
IgG 13.5g/L.Treatment rheumatoid arthritis has better effects, and all diseases substantially alleviate, stable disease, peace
Atoxic side effect.
Embodiment two:
Raw material: 30 parts of the root of Chinese clematis, windproof 15 parts, semen brassicae 10 parts, caulis lonicerae 15 parts, the stiff silkworm 10 of system
Part, scorpio 6 parts, centipede 6 parts, the root of Dahurain angelica 10 parts, parched rice benevolence 30 parts, corydalis tuber 20 parts, erythrina bark 20
Part.
Patient, Jiang, female, 50 years old.Both hands metacarpophalangeal joints, PIP, double wrist joint redness heat
Bitterly, double knee joint swells and ache, limitation of activity, and companion joint is stiff for morning, meets chill arthralgia more so, neck contraction
Discomfort, patient is conscious weak, uneasy sleeping at night, receive food can, two just adjust.Examine its dimly red tongue, greasy and thin fur,
Examine its thready,rolling and rapid pulse.Look into: ESR60mm/h, CRP20.5mg/l, RF268IU/ml, antiCCP antibody 302
RU/ml, IgG 17.3g/L.This is asthenia in origin and asthenia in superficiality, cold-heat jumble, caused by blockage of phlegm and blood stasis.Slow fire boils medicine 2
Secondary, boil medicine 30 minutes every time, total amount 500ml, every day 1 dose, divide 2 times and be administered orally, treat 3 months, look into
ESR18mm/h, CRP3.0mg/l, RF36IU/ml, antiCCP antibody 53RU/ml, IgG 14.3g/L.
Treatment rheumatoid arthritis has better effects, and all diseases substantially alleviate, stable disease, safe without toxic side effect.
Embodiment three:
Raw material: 15 parts of the root of Chinese clematis, windproof 6 parts, semen brassicae 6 parts, caulis lonicerae 10 parts, the stiff silkworm 6 parts of system,
Scorpio 3 parts, centipede 3 parts, the root of Dahurain angelica 6 parts, parched rice benevolence 15 parts, corydalis tuber 10 parts, erythrina bark 10 parts.
Patient, Chen, female, 45 years old.Both hands PIP swells and ache, double knee joint pain, joint morning
Deadlock, hip is uncomfortable, and dry is weak, chilly all over the body, still can sleep night, receive food can, two just adjust.Examine its tongue
Matter is dark red, and tongue is thin, examines its thready,rolling and rapid pulse.Look into: ESR38mm/h, CRP8.5mg/l, RF146IU/ml,
AntiCCP antibody 172RU/ml, IgG 15.6g/L.This is asthenia in origin and asthenia in superficiality, cold-heat jumble, blockage of phlegm and blood stasis institute
Cause.Slow fire is boiled medicine 2 times, boils medicine 30 minutes every time, total amount 500ml, every day 1 dose, divides 2 times and is administered orally,
Treat 3 months, look into ESR10mm/h, CRP2.6mg/l, RF22IU/ml, antiCCP antibody 33RU/ml,
IgG 13.4g/L.Treatment rheumatoid arthritis has better effects, and all diseases substantially alleviate, stable disease, peace
Atoxic side effect.
Claims (1)
1. the Chinese medicine composition treating rheumatoid arthritis, it is characterised in that by following parts by weight
Raw material is made: the root of Chinese clematis 10～35 parts, windproof 6～20 parts, semen brassicae 6～12 parts, caulis lonicerae 10～20
Part, the stiff silkworm 6 of system～12 parts, scorpio 3～8 parts, centipede 3～8 parts, the root of Dahurain angelica 6～15 parts, parched rice benevolence 10～
30 parts, corydalis tuber 10～25 parts, erythrina bark 10～25 parts.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106236995A (en) * | 2016-08-25 | 2016-12-21 | 杜春响 | One treats rheumatoid Chinese medicine composition and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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Application publication date: 20160810 |