CN105816811A - 一种治疗心绞痛的中药组合物及其制备方法 - Google Patents

一种治疗心绞痛的中药组合物及其制备方法 Download PDF

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CN105816811A
CN105816811A CN201610284286.XA CN201610284286A CN105816811A CN 105816811 A CN105816811 A CN 105816811A CN 201610284286 A CN201610284286 A CN 201610284286A CN 105816811 A CN105816811 A CN 105816811A
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何佑兵
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Abstract

本发明公开了一种治疗心绞痛的中药组合物及其制备方法，治疗心绞痛的中药组合物按照重量的原料包括：荜茇、葛根、槟榔、丹参、徐长卿、隔山香、瓜蒌、薤白、法半夏、川芎、红花、广郁金、血竭、白蔻仁、石菖蒲、桂枝、郁金、枳实、姜黄、竹茹、葶苈子、北刘寄奴、鸡血藤、穿山龙、合欢皮、五灵脂、赤芍、降香。本发明中中药制剂所选药材配伍相宜，具有活血通络、理气止痛、清热利湿、养心益肾之功效，使用方便，吸收效果好，无不良及毒副作用，其中鸡血藤、穿山龙能短期内快速抗凝，增加冠脉血流量，保护缺血心肌、调节脂质代谢，有改善造血系统、降血脂、抗血栓形成、消除或软化动脉粥样硬化的斑块，提高机体免疫的能力。

Description

一种治疗心绞痛的中药组合物及其制备方法
技术领域
本发明涉及中药制备技术领域，具体是一种治疗心绞痛的中药组合物及其制备方法。
背景技术
心绞痛是冠状动脉供血不足导致心肌急剧的、暂时缺血与缺氧所引起的，以发作性胸痛或胸部不适为主要表现的临床综合征；特点为前胸阵发性、压榨性疼痛，可伴有其他症状，疼痛主要位于胸骨后部，可放射至心前区与左上肢，劳动或情绪激动时常发生，每次发作持续3-5分钟，可数日一次，也可一日数次，休息或用硝酸醋制剂后消失。本病多见于男性，多数40岁以上，劳累、情绪激动、饱食、受寒、阴雨天气、急性循环衰竭等为常见诱因。
心绞痛的直接发病原因是心肌供血不足，而心肌供血不足主要源于冠心病。有时，其他类型的心脏病或失控的高血压也能引起心绞痛。如果血管中脂肪不断沉积，就会形成斑块。斑块若发生在冠状动脉，就会导致其缩窄，进一步减少其对心肌的供血，就形成了冠心病。冠状动脉内脂肪不断沉积逐渐形成斑块的过程称为冠状动脉硬化。一些斑块比较坚硬而稳定，就会导致冠状动脉本身的缩窄和硬化。另外一些斑块比较柔软，容易碎裂形成血液凝块。冠状动脉内壁这种斑块的积累会以以下两种方式引起心绞痛:冠状动脉的固定位置管腔缩窄，进而导致经过的血流大大减少；形成的血液凝块部分或者全部阻塞冠状动脉。
心绞痛目前在我国的发病率呈逐年上升趋势，严重危害着人民群众的健康和生活，所以普及宣传心绞痛的知识，积极有效地防止冠心病是对于提高人民群众的健康是有重要意义的，心绞痛患者常服用的药物较多，这些药物虽然当时都有一定疗效，但不能从根本上治愈，不能彻底治愈心绞痛病一直是医学研究难题，为此研制一种新的药物来帮助患者摆脱心绞痛成为医学研究的一项新的重要课题。
发明内容
本发明的目的在于提供一种见效快、治愈率高的治疗心绞痛的中药组合物及其制备方法，以解决上述背景技术中提出的问题。
为实现上述目的，本发明提供如下技术方案：
一种治疗心绞痛的中药组合物，按照重量份的原料包括：荜茇40-50份、葛根20-30份、槟榔10-20份、丹参5-10份、徐长卿10-20份、隔山香20-30份、瓜蒌10-20份、薤白8-12份、法半夏5-10份、川芎5-10份、红花6-8份、广郁金5-10份、血竭3-5份、白蔻仁2-4份、石菖蒲6-8份、桂枝10-20份、郁金3-5份、枳实10-20份、姜黄15-25份、竹茹5-15份、葶苈子7-9份、北刘寄奴10-15份、鸡血藤10-15份、穿山龙5-15份、合欢皮4-6份、五灵脂3-5份、赤芍10-20份、降香10-20份。
作为本发明进一步的方案：所述治疗心绞痛的中药组合物，按照重量份的原料包括：荜茇42-48份、葛根22-28份、槟榔12-18份、丹参6-9份、徐长卿12-18份、隔山香22-28份、瓜蒌12-18份、薤白9-11份、法半夏6-9份、川芎6-9份、红花6.5-7.5份、广郁金6-9份、血竭3.5-4.5份、白蔻仁2.5-3.5份、石菖蒲6.5-7.5份、桂枝12-18份、郁金3.5-4.5份、枳实12-18份、姜黄18-22份、竹茹8-12份、葶苈子7.5-8.5份、北刘寄奴11-14份、鸡血藤11-14份、穿山龙8-12份、合欢皮4.5-5.5份、五灵脂3.5-4.5份、赤芍12-18份、降香12-18份。
作为本发明再进一步的方案：所述治疗心绞痛的中药组合物，按照重量份的原料包括：荜茇45份、葛根25份、槟榔15份、丹参8份、徐长卿15份、隔山香25份、瓜蒌15份、薤白10份、法半夏8份、川芎8份、红花7份、广郁金8份、血竭4份、白蔻仁3份、石菖蒲7份、桂枝15份、郁金4份、枳实15份、姜黄20份、竹茹10份、葶苈子8份、北刘寄奴12份、鸡血藤12份、穿山龙10份、合欢皮5份、五灵脂4份、赤芍15份、降香15份。
所述治疗心绞痛的中药组合物的制备方法，具体步骤如下：
(1)按照重量份称取各原料；
(2)将荜茇、葛根、法半夏、川芎、北刘寄奴和鸡血藤放入容器中，加入总质量3-5倍的清水进行浸泡，浸泡时间为60-80min；
(3)将浸泡好的原料药放入小型干燥机中进行干燥，干燥后粉碎，过100-140目滤网过滤得到细粉；
(4)将槟榔、隔山香、薤白和五灵脂去除杂质，洗净，切片，晒干，至于容器内，研末，得到过160-200目的细粉，备用；
(5)将丹参、血竭、穿山龙和合欢皮去除杂质，洗净，置于容器内，加入黄酒拌匀，炒干，取出晾凉，研末，得到过160-200目的细粉，备用；
(6)将徐长卿、瓜蒌、红花、广郁金、白蔻仁、石菖蒲、桂枝、郁金、枳实、姜黄、竹茹、葶苈子、赤芍和降香去除杂质，洗净，放入容器中，加6-8倍量蒸馏水，煎煮1-3h，提取煎煮液；再加入4-6倍量蒸馏水，煎煮1-2h，提取煎煮液，最后合并2次提取的煎煮液，过滤，得滤液，浓缩成60℃下相对密度为1.1-1.14的稠膏，干燥后得到干膏；
(7)将步骤(3)-步骤(6)得到的细粉和干膏混合均匀，加入80-90份的批把蜜，搅拌均匀，置于不锈钢糖衣机中，启动糖衣机，获得丸剂，丸剂的粒径为2.0-2.5cm。
与现有技术相比，本发明的有益效果是：
本发明中中药制剂所选药材配伍相宜，符合中医药学和现代医药学研究理论，具有活血通络、理气止痛、清热利湿、养心益肾之功效，使用方便，吸收效果好，无不良及毒副作用，其中鸡血藤、穿山龙的作用类似于西药抗凝剂和血小板抑制剂，能短期内快速抗凝，增加冠脉血流量，保护缺血心肌、调节脂质代谢，有改善造血系统、降血脂、抗血栓形成、消除或软化动脉粥样硬化的斑块，提高机体免疫的能力。
具体实施方式
下面结合具体实施方式对本专利的技术方案作进一步详细地说明。
实施例1
一种治疗心绞痛的中药组合物，按照重量份的原料包括：荜茇40份、葛根20份、槟榔10份、丹参5份、徐长卿10份、隔山香20份、瓜蒌10份、薤白8份、法半夏5份、川芎5份、红花6份、广郁金5份、血竭3份、白蔻仁2份、石菖蒲6份、桂枝10份、郁金3份、枳实10份、姜黄15份、竹茹5份、葶苈子7份、北刘寄奴10份、鸡血藤10份、穿山龙5份、合欢皮4份、五灵脂3份、赤芍10份、降香10份。所述治疗心绞痛的中药组合物的制备方法，具体步骤如下：
(1)按照重量份称取各原料；
(2)将荜茇、葛根、法半夏、川芎、北刘寄奴和鸡血藤放入容器中，加入总质量3倍的清水进行浸泡，浸泡时间为60min；
(3)将浸泡好的原料药放入小型干燥机中进行干燥，干燥后粉碎，过100目滤网过滤得到细粉；
(4)将槟榔、隔山香、薤白和五灵脂去除杂质，洗净，切片，晒干，至于容器内，研末，得到过160目的细粉，备用；
(5)将丹参、血竭、穿山龙和合欢皮去除杂质，洗净，置于容器内，加入黄酒拌匀，炒干，取出晾凉，研末，得到过160目的细粉，备用；
(6)将徐长卿、瓜蒌、红花、广郁金、白蔻仁、石菖蒲、桂枝、郁金、枳实、姜黄、竹茹、葶苈子、赤芍和降香去除杂质，洗净，放入容器中，加6倍量蒸馏水，煎煮1h，提取煎煮液；再加入4倍量蒸馏水，煎煮1h，提取煎煮液，最后合并2次提取的煎煮液，过滤，得滤液，浓缩成60℃下相对密度为1.1的稠膏，干燥后得到干膏；
(7)将步骤(3)-步骤(6)得到的细粉和干膏混合均匀，加入80份的批把蜜，搅拌均匀，置于不锈钢糖衣机中，启动糖衣机，获得丸剂，丸剂的粒径为2.0cm。
实施例2
一种治疗心绞痛的中药组合物，按照重量份的原料包括：荜茇42份、葛根22份、槟榔12份、丹参6份、徐长卿12份、隔山香22份、瓜蒌12份、薤白9份、法半夏6份、川芎6份、红花6.5份、广郁金6份、血竭3.5份、白蔻仁2.5份、石菖蒲6.5份、桂枝12份、郁金3.5份、枳实12份、姜黄18份、竹茹8份、葶苈子7.5份、北刘寄奴11份、鸡血藤11份、穿山龙8份、合欢皮4.5份、五灵脂3.5份、赤芍12份、降香12份。
所述治疗心绞痛的中药组合物的制备方法，具体步骤如下：
(1)按照重量份称取各原料；
(2)将荜茇、葛根、法半夏、川芎、北刘寄奴和鸡血藤放入容器中，加入总质量3.5倍的清水进行浸泡，浸泡时间为65min；
(3)将浸泡好的原料药放入小型干燥机中进行干燥，干燥后粉碎，过110目滤网过滤得到细粉；
(4)将槟榔、隔山香、薤白和五灵脂去除杂质，洗净，切片，晒干，至于容器内，研末，得到过170目的细粉，备用；
(5)将丹参、血竭、穿山龙和合欢皮去除杂质，洗净，置于容器内，加入黄酒拌匀，炒干，取出晾凉，研末，得到过170目的细粉，备用；
(6)将徐长卿、瓜蒌、红花、广郁金、白蔻仁、石菖蒲、桂枝、郁金、枳实、姜黄、竹茹、葶苈子、赤芍和降香去除杂质，洗净，放入容器中，加6.5倍量蒸馏水，煎煮1.5h，提取煎煮液；再加入4.5倍量蒸馏水，煎煮1.2h，提取煎煮液，最后合并2次提取的煎煮液，过滤，得滤液，浓缩成60℃下相对密度为1.11的稠膏，干燥后得到干膏；
(7)将步骤(3)-步骤(6)得到的细粉和干膏混合均匀，加入82份的批把蜜，搅拌均匀，置于不锈钢糖衣机中，启动糖衣机，获得丸剂，丸剂的粒径为2.1cm。
实施例3
一种治疗心绞痛的中药组合物，按照重量份的原料包括：荜茇45份、葛根25份、槟榔15份、丹参8份、徐长卿15份、隔山香25份、瓜蒌15份、薤白10份、法半夏8份、川芎8份、红花7份、广郁金8份、血竭4份、白蔻仁3份、石菖蒲7份、桂枝15份、郁金4份、枳实15份、姜黄20份、竹茹10份、葶苈子8份、北刘寄奴12份、鸡血藤12份、穿山龙10份、合欢皮5份、五灵脂4份、赤芍15份、降香15份。
所述治疗心绞痛的中药组合物的制备方法，具体步骤如下：
(1)按照重量份称取各原料；
(2)将荜茇、葛根、法半夏、川芎、北刘寄奴和鸡血藤放入容器中，加入总质量4倍的清水进行浸泡，浸泡时间为70min；
(3)将浸泡好的原料药放入小型干燥机中进行干燥，干燥后粉碎，过120目滤网过滤得到细粉；
(4)将槟榔、隔山香、薤白和五灵脂去除杂质，洗净，切片，晒干，至于容器内，研末，得到过180目的细粉，备用；
(5)将丹参、血竭、穿山龙和合欢皮去除杂质，洗净，置于容器内，加入黄酒拌匀，炒干，取出晾凉，研末，得到过180目的细粉，备用；
(6)将徐长卿、瓜蒌、红花、广郁金、白蔻仁、石菖蒲、桂枝、郁金、枳实、姜黄、竹茹、葶苈子、赤芍和降香去除杂质，洗净，放入容器中，加7倍量蒸馏水，煎煮2h，提取煎煮液；再加入5倍量蒸馏水，煎煮1.5h，提取煎煮液，最后合并2次提取的煎煮液，过滤，得滤液，浓缩成60℃下相对密度为1.12的稠膏，干燥后得到干膏；
(7)将步骤(3)-步骤(6)得到的细粉和干膏混合均匀，加入85份的批把蜜，搅拌均匀，置于不锈钢糖衣机中，启动糖衣机，获得丸剂，丸剂的粒径为2.2cm。
实施例4
一种治疗心绞痛的中药组合物，按照重量份的原料包括：荜茇48份、葛根28份、槟榔18份、丹参9份、徐长卿18份、隔山香28份、瓜蒌18份、薤白11份、法半夏9份、川芎9份、红花7.5份、广郁金9份、血竭4.5份、白蔻仁3.5份、石菖蒲7.5份、桂枝18份、郁金4.5份、枳实18份、姜黄22份、竹茹12份、葶苈子8.5份、北刘寄奴14份、鸡血藤14份、穿山龙12份、合欢皮5.5份、五灵脂4.5份、赤芍18份、降香18份。
所述治疗心绞痛的中药组合物的制备方法，具体步骤如下：
(1)按照重量份称取各原料；
(2)将荜茇、葛根、法半夏、川芎、北刘寄奴和鸡血藤放入容器中，加入总质量4.5倍的清水进行浸泡，浸泡时间为75min；
(3)将浸泡好的原料药放入小型干燥机中进行干燥，干燥后粉碎，过130目滤网过滤得到细粉；
(4)将槟榔、隔山香、薤白和五灵脂去除杂质，洗净，切片，晒干，至于容器内，研末，得到过190目的细粉，备用；
(5)将丹参、血竭、穿山龙和合欢皮去除杂质，洗净，置于容器内，加入黄酒拌匀，炒干，取出晾凉，研末，得到过190目的细粉，备用；
(6)将徐长卿、瓜蒌、红花、广郁金、白蔻仁、石菖蒲、桂枝、郁金、枳实、姜黄、竹茹、葶苈子、赤芍和降香去除杂质，洗净，放入容器中，加7.5倍量蒸馏水，煎煮2.5h，提取煎煮液；再加入5.5倍量蒸馏水，煎煮1.8h，提取煎煮液，最后合并2次提取的煎煮液，过滤，得滤液，浓缩成60℃下相对密度为1.13的稠膏，干燥后得到干膏；
(7)将步骤(3)-步骤(6)得到的细粉和干膏混合均匀，加入88份的批把蜜，搅拌均匀，置于不锈钢糖衣机中，启动糖衣机，获得丸剂，丸剂的粒径为2.4cm。
实施例5
一种治疗心绞痛的中药组合物，按照重量份的原料包括：荜茇50份、葛根30份、槟榔20份、丹参10份、徐长卿20份、隔山香30份、瓜蒌20份、薤白12份、法半夏10份、川芎10份、红花8份、广郁金10份、血竭5份、白蔻仁4份、石菖蒲8份、桂枝20份、郁金5份、枳实20份、姜黄25份、竹茹15份、葶苈子9份、北刘寄奴15份、鸡血藤15份、穿山龙15份、合欢皮6份、五灵脂5份、赤芍20份、降香20份。所述治疗心绞痛的中药组合物的制备方法，具体步骤如下：
(1)按照重量份称取各原料；
(2)将荜茇、葛根、法半夏、川芎、北刘寄奴和鸡血藤放入容器中，加入总质量5倍的清水进行浸泡，浸泡时间为80min；
(3)将浸泡好的原料药放入小型干燥机中进行干燥，干燥后粉碎，过140目滤网过滤得到细粉；
(4)将槟榔、隔山香、薤白和五灵脂去除杂质，洗净，切片，晒干，至于容器内，研末，得到过200目的细粉，备用；
(5)将丹参、血竭、穿山龙和合欢皮去除杂质，洗净，置于容器内，加入黄酒拌匀，炒干，取出晾凉，研末，得到过200目的细粉，备用；
(6)将徐长卿、瓜蒌、红花、广郁金、白蔻仁、石菖蒲、桂枝、郁金、枳实、姜黄、竹茹、葶苈子、赤芍和降香去除杂质，洗净，放入容器中，加8倍量蒸馏水，煎煮3h，提取煎煮液；再加入6倍量蒸馏水，煎煮2h，提取煎煮液，最后合并2次提取的煎煮液，过滤，得滤液，浓缩成60℃下相对密度为1.14的稠膏，干燥后得到干膏；
(7)将步骤(3)-步骤(6)得到的细粉和干膏混合均匀，加入90份的批把蜜，搅拌均匀，置于不锈钢糖衣机中，启动糖衣机，获得丸剂，丸剂的粒径为2.5cm。
典型病例：
(1)徐某，女，51岁，患者由于冠状动脉粥样硬化狭窄导致冠状动脉供血不足，心肌暂时缺血与缺氧所引起心前区疼痛。被确诊为心绞痛。曾使用过其他药物，效果不佳。服用本发明中药制剂10天后，症状明显好转，继续服用一个月后，以上症状消失，恢复健康，没有复发。
(2)王某，男，52岁，患冠心病心绞痛10年，2014在某医院行冠状动脉旁路移植术，术后三个月，心绞痛复发，患者乏力、大便畅、舌嫩红、苔白润、左寸脉弱，中医诊断为胸痹。服用本发明中药制剂剂7天后，胸痛未发，偶发胸闷，面色红润，继续服用20天后，症状基本消失。2015年12月打电话询问得知，患者胸痛、胸闷一直没有复发，乏力基本消失，睡眠质量高，精神极佳。
(3)刘某，女，62岁，因过度劳累后突感心胸剧痛、如刺如绞、痛有定处，胸闷气短、动则尤甚，心慌。经心电图检查为冠心病心绞痛发作，口服本发明中药制剂治疗20天后，症状显著减轻，40天后，症状完全消失，心电图正常，随访一年未复发。
本发明中中药制剂所选药材配伍相宜，符合中医药学和现代医药学研究理论，具有活血通络、理气止痛、清热利湿、养心益肾之功效，使用方便，吸收效果好，无不良及毒副作用，其中鸡血藤、穿山龙的作用类似于西药抗凝剂和血小板抑制剂，能短期内快速抗凝，增加冠脉血流量，保护缺血心肌、调节脂质代谢，有改善造血系统、降血脂、抗血栓形成、消除或软化动脉粥样硬化的斑块，提高机体免疫的能力。
上面对本专利的较佳实施方式作了详细说明，但是本专利并不限于上述实施方式，在本领域的普通技术人员所具备的知识范围内，还可以在不脱离本专利宗旨的前提下作出各种变化。

Claims (4)

1.一种治疗心绞痛的中药组合物，其特征在于，按照重量份的原料包括：荜茇40-50份、葛根20-30份、槟榔10-20份、丹参5-10份、徐长卿10-20份、隔山香20-30份、瓜蒌10-20份、薤白8-12份、法半夏5-10份、川芎5-10份、红花6-8份、广郁金5-10份、血竭3-5份、白蔻仁2-4份、石菖蒲6-8份、桂枝10-20份、郁金3-5份、枳实10-20份、姜黄15-25份、竹茹5-15份、葶苈子7-9份、北刘寄奴10-15份、鸡血藤10-15份、穿山龙5-15份、合欢皮4-6份、五灵脂3-5份、赤芍10-20份、降香10-20份。
2.根据权利要求1所述的治疗心绞痛的中药组合物，其特征在于，按照重量份的原料包括：荜茇42-48份、葛根22-28份、槟榔12-18份、丹参6-9份、徐长卿12-18份、隔山香22-28份、瓜蒌12-18份、薤白9-11份、法半夏6-9份、川芎6-9份、红花6.5-7.5份、广郁金6-9份、血竭3.5-4.5份、白蔻仁2.5-3.5份、石菖蒲6.5-7.5份、桂枝12-18份、郁金3.5-4.5份、枳实12-18份、姜黄18-22份、竹茹8-12份、葶苈子7.5-8.5份、北刘寄奴11-14份、鸡血藤11-14份、穿山龙8-12份、合欢皮4.5-5.5份、五灵脂3.5-4.5份、赤芍12-18份、降香12-18份。
3.根据权利要求1所述的治疗心绞痛的中药组合物，其特征在于，按照重量份的原料包括：荜茇45份、葛根25份、槟榔15份、丹参8份、徐长卿15份、隔山香25份、瓜蒌15份、薤白10份、法半夏8份、川芎8份、红花7份、广郁金8份、血竭4份、白蔻仁3份、石菖蒲7份、桂枝15份、郁金4份、枳实15份、姜黄20份、竹茹10份、葶苈子8份、北刘寄奴12份、鸡血藤12份、穿山龙10份、合欢皮5份、五灵脂4份、赤芍15份、降香15份。
4.一种如权利要求1-3任一所述的治疗心绞痛的中药组合物的制备方法，其特征在于，具体步骤如下：
(1)按照重量份称取各原料；
(2)将荜茇、葛根、法半夏、川芎、北刘寄奴和鸡血藤放入容器中，加入总质量3-5倍的清水进行浸泡，浸泡时间为60-80min；
(3)将浸泡好的原料药放入小型干燥机中进行干燥，干燥后粉碎，过100-140目滤网过滤得到细粉；
(4)将槟榔、隔山香、薤白和五灵脂去除杂质，洗净，切片，晒干，至于容器内，研末，得到过160-200目的细粉，备用；
(5)将丹参、血竭、穿山龙和合欢皮去除杂质，洗净，置于容器内，加入黄酒拌匀，炒干，取出晾凉，研末，得到过160-200目的细粉，备用；
(6)将徐长卿、瓜蒌、红花、广郁金、白蔻仁、石菖蒲、桂枝、郁金、枳实、姜黄、竹茹、葶苈子、赤芍和降香去除杂质，洗净，放入容器中，加6-8倍量蒸馏水，煎煮1-3h，提取煎煮液；再加入4-6倍量蒸馏水，煎煮1-2h，提取煎煮液，最后合并2次提取的煎煮液，过滤，得滤液，浓缩成60℃下相对密度为1.1-1.14的稠膏，干燥后得到干膏；
(7)将步骤(3)-步骤(6)得到的细粉和干膏混合均匀，加入80-90份的批把蜜，搅拌均匀，置于不锈钢糖衣机中，启动糖衣机，获得丸剂，丸剂的粒径为2.0-2.5cm。
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