CN105816804A - 一种治疗肝结石的药物及其制备 - Google Patents

一种治疗肝结石的药物及其制备 Download PDF

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CN105816804A
CN105816804A CN201610240794.8A CN201610240794A CN105816804A CN 105816804 A CN105816804 A CN 105816804A CN 201610240794 A CN201610240794 A CN 201610240794A CN 105816804 A CN105816804 A CN 105816804A
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陈中元
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Abstract

一种治疗肝结石的药物，由以下药物组成：金钱草，海金沙，鸡内金，黄芩，枳壳，茵陈，延胡索，麦芽，甘草，大黄，炒栀子，牡丹皮，薄荷，郁金，白芍，当归，柴胡，茯苓，白术，香附，神曲；本发明还提供了该药物的制备方法，该药物可疏解肝郁，快速治愈肝结石。

Description

一种治疗肝结石的药物及其制备
技术领域
本发明属于纯中药配方技术领域，特别涉及一种治疗肝结石的药物及其制备。
背景技术
肝结石在病程间歇期，可无症状，或仅表现为上腹轻度不适。急性期出现上腹部疼痛，可表现为典型胆绞痛或持续性胀痛，有的病人疼痛不明显，而寒颤发热非常厉害，周期发作，这种周期性的间歇发作是肝内胆管结石的特征性临床表现。可有长期的胆道病史，或伴有寒颤发热、黄疸的急性胆管炎史；患侧肝区及下胸部有经常性疼痛不适，常放射至背、肩部；一侧肝管梗阻时，可无黄疸或黄疸甚轻；合并有重症胆管炎时，全身情况比较严重，且急性发作后恢复较慢；检查时，肝区压痛和叩击痛明显，肝脏呈不对称性肿大并有压痛；全身状况受影响明显，90％病人有低蛋白血症，1/3病人有明显贫血；晩期会有肝、脾肿大及门脉高压表现。肝结石一般无明显症状，往往是体检时才发现，结石大的话可以引起疼痛，堵塞胆道时可引起黄疸，发热，肝区疼痛，严重时危及生命。
西医对肝结石以手术为治疗原则，具有手术治疗风险性大，术后恢复困难且痛苦的缺点。
相应地，中医对肝结石以标本兼治为原理，通过溶石、排石，活血清热理气的方法能够部分克服西医治疗的缺点，然而，目前的中医治疗所用药物，仍然存在一些缺点，例如，申请号为98120627.1的中国专利公开了治肝丸，组方：蟾酥、牛黄、巴豆、珍珠、麝香、灯心草、黄连、地丁、铜绿、车前子、大黄、寒水石、白矾、冰片、羚羊角、雄黄、血竭、葶苈子、蜂蜜。申请号为200810147178.3的中国专利公开了可治疗阑尾炎、胆囊炎、输卵管疾病及结石类疾病的中药，组方：没药、儿茶、藏红花、当归尾、血竭、川射香、梅片、珠砂、大米酒。实践中发现两者的效果不好，不能彻底治愈肝结石。
发明内容
为了克服上述现有技术的缺点，本发明的目的在于提供一种治疗肝结石的药物及其制备，该药物可疏解肝郁，快速治愈肝结石。
为了实现上述目的，本发明采用的技术方案是：
一种治疗肝结石的药物，由以下重量份的药物组成：
金钱草40g-60g，海金沙20g-30g，鸡内金20g-30g，黄芩10g-20g，枳壳10g-15g，茵陈15g-25g，延胡索12g-18g，麦芽10g-20g，甘草8g-15g，大黄5g-12g，炒栀子10g-15g，牡丹皮12g-20g，薄荷6g-12g，郁金12g-18g，白芍30g-40g，当归10g-30g，柴胡10g-15g，茯苓15g-30g，白术10g-30g，香附10g-18g，神曲10g-20g。
本发明药物的制备及使用方法，按重量取好药物，放适量水(淹没药物即可)，将药物浸泡一小时左右，用大火烧开后，减至小火熬15分钟后倒出药液；再加适量水，熬第二次，用大火烧开后，减至小火熬20分钟后倒出药液；再加适量水，熬第三次，用大火烧开后，减至小火熬25分钟后倒出药液，三次所得药液混合，分三次服用，饭后服用。
本发明以清热利湿、清肝胆湿热、解毒、利水通淋、排石、利水消肿、化坚消石、运脾消食、燥湿、泻火解毒、止血、破气消积、化痰除痞、利湿退黃、活血行气止痛、补脾益气、润肺止咳、缓急止痛、泻下功积、泻火、活血祛瘀、利水、清化湿热、泻火除烦、凉血、清热凉血、活血散瘀、疏解肝郁、养血敛阴、平抑肝阳、柔肝止痛、补血、活血止痛、润肠、利水渗湿、健脾、补气健脾、燥湿利水、止汗、消食和胃为基本治疗原理，能达到疏解肝郁，快速治愈的效果。
具体实施方式
下面结合实施例详细说明本发明的实施方式。
本发明各组份药理作用为：
金钱草：甘、咸，微寒；归肝、胆、肾、膀胱经；功效：清热利湿，通淋，清肝胆湿热，清热解毒；主治：热淋、石淋，肝胆结石，黄疸，热毒痈肿，毒蛇咬伤。
海金沙：甘、淡，寒；归膀胱，小肠经；功效：利水通淋，排石，利水消肿。主治：淋病，肝胆结石，脾湿肿满。
鸡内金：甘、平；归脾胃、小肠、膀胱经；功效：运脾消食，固精止遗；本品尚有化坚消石之功，对泌尿系结石及胆结石作用。主治：消化不良，食积不化，小儿疳积证，遗尿，遗精。
黄芩：苦、寒；归肺、胆、胃、大肠经；功效：清热燥湿，泻火解毒，止血，安胎；主治：湿温，黄疸，泻痢，热琳。气分实热，肺热咳嗽，痈肿疮毒。血热吐衄，咳血，便血，崩漏，胎热不安。
枳壳：苦、辛，微寒；归脾、胃、大肠经；功效：破气消积，化痰除痞。主治：食积停滞，腹痛便秘，泻痢不畅，里急后重证，痰浊阻塞，胸脘痞满证，但作用比枳实缓和，长于行气宽中。
茵陈：味苦，微寒；归脾胃、肝、胆经；功效：清热利湿退黃。主治：黄疸，胆结石症，湿温病，湿疮，疥癣，风疹。
延胡索：辛、苦，温；归心、肝、脾经；功效：活血行气止痛；主治：血瘀气滞诸痛证。
麦芽：味甘、平；归脾、胃、肝经；功效：消食和中，回乳。主治：食积停滞，消化不良，妇女断乳，乳房胀痛。
甘草：甘、平；归脾、胃、脾、心经；功效：补脾益气，润肺止咳，缓急止痛，清热解毒。主治：脾胃虚弱证，心虚动悸脉结代证，脏躁证，诸咳喘证，脘腹或四肢挛急作痛，痈疽疮肿，咽喉肿痛，食物、药物及农药中毒，缓和药性，调和百药。
大黄：苦、寒；归脾、胃、大肠肝心经；功效：泻下功积，泻火，清热解毒，活血祛瘀，利水，清化湿热。主治：积滞实证，痢疾，实火头痛、目赤、咽痛、口疮等，热性出血，热毒疮疡，烧伤，肠痈，经闭，产后恶露不下，癥瘕，跌打损伤，水肿，黄疸，淋证。
炒栀子：味苦，寒；归心、肺、胃、三焦经；功效：泻火除烦，淸热利湿，凉血解毒。主治：热病心烦，高热烦躁，湿热黄疸，小便短赤，热淋，血淋，血热出血，痈肿疮毒，外用治扭挫伤，炒栀子苦寒之性稍缓，长于清热除烦，用于热病心烦。
牡丹皮：苦、辛、微寒；归心、肝、肾经；功效：清热凉血，活血散瘀。主治：血热发斑疹，吐衄，月经先期，经前发热，阴虚发热，血滞经闭，癥积，外疡内痈。
薄荷：辛、凉；归肝、肺经；功效：疏散风热，清利头目，利咽透疹，疏解肝郁，辟秽气。主治：外感风热证，风热头痛，目赤证，风热上功之咽喉肿痛，麻疹透发不畅证，肝气郁滞胸闷，胁肋胀痛证，痧胀腹痛吐泻证。
郁金：辛、苦、寒；归心、肝、胆经；功效：活血止痛，行气解郁，清热凉血，清心开窍，利胆退黄；主治：胁痛，痛经，月经不调，癥瘕积快，吐血，衄血，尿血，倒经，神志不清，癫痫，癫狂证，湿热黄疸。
白芍：苦、酸、微寒；归肝、脾经；功效：养血敛阴，平抑肝阳，柔肝止痛；主治：肝血亏虚证，月经不调，胎产诸证，体虚多汗证，阴虚动风证，肝阳上亢证，肝急诸痛证。
当归：甘、辛、温；归肝、心、脾经；功效：补血，活血止痛，润肠。主治：心肝血虚证，月经不调，痛经，经闭，胎前产后诸疾，跌扑损伤，痹痛麻木，痈疽疮疡，血虚肠燥证，兼治咳喘。
柴胡：苦、平、微寒；归肝、胆经；功效：和解退热，疏肝解郁，升举阳气。主治：伤寒邪在少阳经，肝郁气滞之证，气虚下陷诸证。
茯苓：甘、淡，平；归心、脾、肾经；功效：利水渗湿，健脾，安神。主治：小便不利，水肿，痰饮，脾气虚弱证，心悸，失眠。
白术：苦、甘、温；归脾、胃经；功效：补气健脾，燥湿利水，止汗，安胎；主治：脾胃气虚证，水肿证，痰饮证，气虚自汗证，咍动不安证；药理：抗溃疡，抗肿瘤。
香附：辛、微苦、微甘、平；归肝、三焦经。功效：疏肝理气，调经止痛。主治：肝郁气滞证，疝气痛证，月经不调，痛经，乳房胀痛等证。
神曲:甘、辛、温。归脾、胃经。功效：消食和胃。主治：食积不化，脘腹胀满食少，或肠鸣泄泻。
以上药物均可在普通中药店购买得到。
本发明药物组合协同作用可达到快速治愈肝结石的目的，以下为本发明的若干实施例。
实施例一
临床实验对象：
吴某，女，43岁，出现上腹部疼痛，持续性胀痛，寒战发热，周期发作，右侧肝区及下胸部有经常性疼痛不适，常放射至背、肩部，食欲不振。去医院做B超检査，结果是肝胆管结石，经西医治疗一段时间无效。
用本实施例药物：
金钱草40g，海金沙20g，鸡内金20g，黄芩20g，枳壳10g，茵陈15g，延胡索12g，麦芽10g，甘草8g，大黄5g，炒栀子10g，牡丹皮12g，薄荷6g，郁金12g，白芍30g，当归10g，柴胡10g，茯苓15g，白术10g，香附10g，神曲10g。
用法：按重量取好药物，放适量水，将药物浸泡一小时左右，用大火烧开后，减至小火熬15分钟后倒出药液，再加适量水，熬第二次，用大火烧开后，减至小火熬20分钟后倒出药液，再加适量水，熬第三次，用大火烧开后，减至小火熬25分钟后倒出药液，三次所得药液混合，是为一剂，分三次服用，饭后服用，一日服完。
效果：三剂后症状基本消失，连续服用十五剂后，去医院做B超检査，结果肝胆管结石消失。
实施例二
临床实验对象：
张某，男，47岁，出现右腹部疼痛，持续性胀痛，右侧肝区及下胸部有经常性疼痛不适，食欲不振，去医院做B超检査，结果是肝胆管结石，经多处开药服用无效。
用本实施例药物：
金钱草50g，海金沙25g，鸡内金25g，黄芩15g，枳壳15g，茵陈15g，延胡索12g，麦芽10g，甘草10g，大黄5g，炒栀子10g，牡丹皮12g，薄荷6g，郁金12g，白芍30g，当归10g，柴胡10g，茯苓15g，白术10g，香附10g，神曲10g。
用法：按重量取好药物，放适量水，将药物浸泡一小时左右，用大火烧开后，减至小火熬15分钟后倒出药液，再加适量水，熬第二次，用大火烧开后，减至小火熬20分钟后倒出药液，再加适量水，熬第三次，用大火烧开后，减至小火熬25分钟后倒出药液，三次所得药液混合，是为一剂，分三次服用，饭后服用，一日服完。
效果：二剂后症状基本消失，连续服用十五剂后，去医院做B超检査，结果肝胆管结石消失。
实施例三
临床实验对象：
王某，女，52岁，出现上腹部疼痛，持续性胀痛，寒战发热，周期发作，右侧肝区及下胸部有经常性疼痛不适，食欲不振，去医院做B超检査，结果是肝胆管结石，经医院及多处开药服用一段时间，无效。
用本实施例药物：
金钱草60g，海金沙30g，鸡内金30g，黄芩20g，枳壳15g，茵陈25g，延胡索18g，麦芽20g，甘草15g，大黄12g，炒栀子15g，牡丹皮20g，薄荷12g，郁金18g，白芍40g，当归30g，柴胡15g，茯苓30g，白术30g，香附18g，神曲20g。
用法：按重量取好药物，放适量水，将药物浸泡一小时左右，用大火烧开后，减至小火熬15分钟后倒出药液，再加适量水，熬第二次，用大火烧开后，减至小火熬20分钟后倒出药液，再加适量水，熬第三次，用大火烧开后，减至小火熬25分钟后倒出药液，三次所得药液混合，是为一剂，分三次服用，饭后服用，一日服完。
效果：三剂后症状基本消失，连续服用十五剂后，去医院做B超检査，结果肝胆管结石消失。

Claims (3)

1.一种治疗肝结石的药物，其特征在于，由以下重量份的药物组成：
金钱草40g-60g，海金沙20g-30g，鸡内金20g-30g，黄芩10g-20g，枳壳10g-15g，茵陈15g-25g，延胡索12g-18g，麦芽10g-20g，甘草8g-15g，大黄5g-12g，炒栀子10g-15g，牡丹皮12g-20g，薄荷6g-12g，郁金12g-18g，白芍30g-40g，当归10g-30g，柴胡10g-15g，茯苓15g-30g，白术10g-30g，香附10g-18g，神曲10g-20g。
2.根据权利要求1所述的一种治疗肝结石的药物，其特征在于，由以下重量份的药物组成：
金钱草50g，海金沙25g，鸡内金25g，黄芩15g，枳壳15g，茵陈15g，延胡索12g，麦芽10g，甘草10g，大黄5g，炒栀子10g，牡丹皮12g，薄荷6g，郁金12g，白芍30g，当归10g，柴胡10g，茯苓15g，白术10g，香附10g，神曲10g。
3.一种制备权利要求1或2所述治疗肝结石的药物的方法，其特征在于，包括如下步骤：按重量取好药物，放适量水，将药物浸泡一小时左右，用大火烧开后，减至小火熬15分钟后倒出药液；再加适量水，熬第二次，用大火烧开后，减至小火熬20分钟后倒出药液；再加适量水，熬第三次，用大火烧开后，减至小火熬25分钟后倒出药液，三次所得药液混合。
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