CN105816794A - 一种治疗中风病的中药组合物 - Google Patents

一种治疗中风病的中药组合物 Download PDF

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CN105816794A
CN105816794A CN201610188552.9A CN201610188552A CN105816794A CN 105816794 A CN105816794 A CN 105816794A CN 201610188552 A CN201610188552 A CN 201610188552A CN 105816794 A CN105816794 A CN 105816794A
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李树波
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Abstract

本发明涉及一种治疗中风病的中药组合物，它包含下列重量份的物质：石菖蒲19份、地龙16份、水蛭16份、当归尾10份、川芎10份、丹参10份、僵蚕10份、红花10份、乌梢蛇12份、土元11份、生黄芪11份、桃仁10份、全蝎5份、蜈蚣6份、郁金7份、胆南星5份、姜黄4份、桂枝3份、木香2份、陈皮1份、半夏1份、菊花2份、钩藤2份、白芍2份和山药2份。本发明的药物所选药材配伍相宜，符合中医药学和现代医药学理论，并具有益气通络、活血化瘀、消肿止痛之功效，对治疗缺血性中风病具有显著的疗效，疗程短，见效快，安全可靠，无毒副作用，治愈后不复发，价格低廉，标本兼治，值得临床上广泛推广应用。

Description

一种治疗中风病的中药组合物
技术领域
本发明涉及医药领域，具体来说涉及一种治疗中风病的中药组合物。
背景技术
缺血性脑中风是脑血管疾病的主要类型，约85％的脑中风是缺血性的，动脉粥样硬化是基础，缺血性脑中风存活的患者面临的最大的问题是再发作和其他缺血性事件的发生。烟毒可损害血管内膜，并能引起小血管收缩，管腔变窄，因而容易形成血栓，大量引用烈性酒，对血管有害无益。据调查，酗酒是引起缺血性脑中风的诱因之一。
随着中医气血相关理论研究的不断深入，现已将缺血性中风的基本病因归纳为气虚血瘀，气虚为本，血瘀为标，病机为气虚血瘀致痹阻脑络，经脉失养，治疗应标本兼治、益气活血，故采用益气活血法治疗缺血性中风已日趋广泛。由此研制出安全有效的治疗缺血性中风的中药将具有较大的市场需求和较好的开发前景。
发明内容
本发明的目的是提供一种治疗中风病的中药组合物。
为了实现本发明的目的，本发明提供一种治疗中风病的中药组合物，它包含下列重量份的物质：石菖蒲19份、地龙16份、水蛭16份、当归尾10份、川芎10份、丹参10份、僵蚕10份、红花10份、乌梢蛇12份、土元11份、生黄芪11份、桃仁10份、全蝎5份、蜈蚣6份、郁金7份、胆南星5份、姜黄4份、桂枝3份、木香2份、陈皮1份、半夏1份、菊花2份、钩藤2份、白芍2份和山药2份。
优选地，本发明所述的治疗中风病的中药组合物还包含下列重量份的物质：0.1份的具有下列结构式的物质：
优选地，所述中药组合物可以是洗剂、软膏剂或粉剂。
本发明还提供具有下列结构式的物质在制备治疗中风病的药物中的用途：
优选地，所述药物可以是洗剂、软膏剂或粉剂。
本发明的药物所选药材配伍相宜，符合中医药学和现代医药学理论，并具有益气通络、活血化瘀、消肿止痛之功效，对治疗缺血性中风病具有显著的疗效，疗程短，见效快，安全可靠，无毒副作用，治愈后不复发，价格低廉，标本兼治，值得临床上广泛推广应用。
具体实施方式
下面通过实施例进一步说明本发明。应该理解的是，本发明的实施例是用于说明本发明而不是对本发明的限制。根据本发明的实质对本发明进行的简单改进都属于本发明要求保护的范围。除非另有说明，否则本发明中的百分数是重量百分数。
实施例1
称取石菖蒲19克、地龙16克、水蛭16克、当归尾10克、川芎10克、丹参10克、僵蚕10克、红花10克、乌梢蛇12克、土元11克、生黄芪11克、桃仁10克、全蝎5克、蜈蚣6克、郁金7克、胆南星5克、姜黄4克、桂枝3克、木香2克、陈皮1克、半夏1克、菊花2克、钩藤2克、白芍2克和山药2克，粉碎，过100目筛，即得。
实施例2
化合物具有下列结构式：
试验例对小鼠凝血时间的影响
取昆明种小鼠50只，体重(18±2)g，雌雄各半，随机分为5组，每组10只。生理盐水阴性对照组，阳性药(脑心通胶囊组，0.3g/粒，咸阳步长制药有限公司生产)组、给药组1、给药组2和给药组3。各组给药量如下：生理盐水阴性对照组，给予生理盐水灌胃1mL/1000g体重；阳性药组，脑心通胶囊内容物10g加1000mL生理盐水配制成混悬液，给予灌胃1mL/1000g体重；给药组1，实施例1的粉末10g加1000mL生理盐水配制成混悬液，给予灌胃1mL/1000g体重；给药组2，0.02g的化合物加1000mL生理盐水配制成混悬液，给予灌胃1mL/1000g体重；给药组3，实施例1的粉末5g和0.01g的化合物加1000mL生理盐水配制成混悬液，给予灌胃1mL/1000g体重。以上均每日1次，连续给药7d。末次给药后60min，取血测定凝血时间，方法如下：用毛细玻璃管将小鼠做眼眶内眦取血，迅速滴血于载玻片上，血滴直径5-10mm，立即开始计时，此后每隔30s用干燥洁净针头挑动血液1次至针头能挑起纤维蛋白为止，即为凝血时间。结果见下表：
和生理盐水阴性对照组比较，*P＜0.05
与生理盐水阴性对照组比较，各治疗组的凝血时间都显著延长，这说明本发明药物均具有延长凝血时间的功效。而中风的一大病因就是血栓形成，因此有望开发成新的治疗药物。

Claims (5)

1.一种治疗中风病的中药组合物，其特征在于，它包含下列重量份的物质：石菖蒲19份、地龙16份、水蛭16份、当归尾10份、川芎10份、丹参10份、僵蚕10份、红花10份、乌梢蛇12份、土元11份、生黄芪11份、桃仁10份、全蝎5份、蜈蚣6份、郁金7份、胆南星5份、姜黄4份、桂枝3份、木香2份、陈皮1份、半夏1份、菊花2份、钩藤2份、白芍2份和山药2份。
2.根据权利要求1所述的治疗中风病的中药组合物，其特征在于，它还包含下列重量份的物质：0.1份的具有下列结构式的物质：
3.根据权利要求2所述的治疗中风病的中药组合物，其特征在于，所述中药组合物可以是洗剂、软膏剂或粉剂。
4.具有下列结构式的物质在制备治疗中风病的药物中的用途：
5.根据权利要求4所述的用途，其特征在于，所述药物可以是洗剂、软膏剂或粉剂。
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CN1328843A (zh) * 2001-06-01 2002-01-02 李树波 一种治疗中风病口服药物速愈散及其制造方法

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CN1328843A (zh) * 2001-06-01 2002-01-02 李树波 一种治疗中风病口服药物速愈散及其制造方法

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