CN104435815A - 一种治疗粘连性肩关节囊炎的外用中药药物 - Google Patents
一种治疗粘连性肩关节囊炎的外用中药药物 Download PDFInfo
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Abstract
一种治疗粘连性肩关节囊炎的外用中药药物,由以下中药原料制成药膏:土鳖虫100g、独活100g、续断100g、羌活150g、川芎100g、红花100g、防风100g、合欢皮100g、连翘120g、黄芩50g、板蓝根50g、千年健50g、威灵仙50g、桂枝50g、荆芥50g、醋制延胡索50g、全蝎50g、细辛50g、洋金花2g、赤石脂50g、自然铜30g、血竭10g、苏木50g、乳香50g、没药50g、炉甘石50g、儿茶50g、茜草50g、虎杖50g、黄药子50g、当归50g、天花粉10g、紫竹叶15g、鲜益母草10g、鲜大蓟10g、鲜小蓟10g、鲜桑叶6g、鲜菊花6g、鲜仙人掌6g。本发明标本兼治,利用多种药物联合活血化瘀、通络镇痛、消肿、疏通病变部位的经络,治愈疾病。
Description
技术领域
本发明涉及一种以中草药为原料制备的中药药物,具体地说是一种用于治疗粘连性肩关节囊炎的外用中药药物。
背景技术
粘连性肩关节囊炎是肩关节囊、滑囊、肌腱及肩周肌的慢性损伤性炎症。其病因多为继发性,如中老年人软组织退行性,对外力承受力减弱;肩部急慢性损伤或上肢因外伤、手术或其他原因长期固定肩关节,使肩部肌肉持续性痉挛、缺血而形成粘连,最后转变为真正的肩周炎。主要症状以肩部逐渐产生疼痛,夜间疼痛为甚,且逐渐加重,肩关节活动功能受限而且日益加重。此病多见于体力劳动者。如得不到有效的治疗,可严重影响肩关节的功能活动,肩关节可有广泛压痛,并向颈部及肘部放射,还可出现不同程度的三角肌的萎缩。利用传统的治疗方法手法松解术,局部痛点封闭,推拿、按摩需要经过很长时间的治疗,且痛苦大,疗效不理想。
发明内容
本发明的目的是提供一种治疗粘连性肩关节囊炎的外用中药药物。
为实现上述目的,本发明采用的技术方案为:
一种治疗粘连性肩关节囊炎的外用中药药物,其特征是,由以下中药原料按以下重量配比和以下制备工艺制成:
土鳖虫100g、独活100g、续断100g、羌活150g、川芎100g、红花100g、防风100g、合欢皮100g、连翘120g、黄芩50g、板蓝根50g、千年健50g、威灵仙50g、桂枝50g、荆芥50g、醋制延胡索50g、全蝎50g、细辛50g、洋金花2g、赤石脂50g、自然铜30g、血竭10g、苏木50g、乳香50g、没药50g、炉甘石50g、儿茶50g、茜草50g、虎杖50g、黄药子50g、当归50g、天花粉10g、紫竹叶15g、鲜益母草10g、鲜大蓟10g、鲜小蓟10g、鲜桑叶6g、鲜菊花6g、鲜仙人掌6g;
其制备工艺为:将上述中草药的根茎、果实、种子经过清洗,烘干工艺,在无菌、无尘的条件下:
(1)将土鳖虫100g、独活100g、续断100g、羌活150g、川芎100g、红花100g、防风100g、合欢皮100g、连翘120g、黄芩50g、板蓝根50g、千年健50g、威灵仙50g、桂枝50g、荆芥50g浸泡于5000ml凉水中半小时,然后煎煮两次:第一次煎煮沸后20分钟,漉出煎液;第二次煎煮沸后10分钟,漉出煎液;然后合并两次煎液浓缩至1000ml,塑封于100ml的塑料袋内备用;
(2)将醋制延胡索50g、全蝎50g、细辛50g、洋金花2g、赤石脂50g、自然铜30g、血竭10g、苏木50g、乳香50g、没药50g、炉甘石50g、儿茶50g、茜草50g、虎杖50g、黄药子50g、当归50g、天花粉10g、紫竹叶15g混匀后碎成细粉,采用环氧乙烷灭菌后分成10等份装入无菌玻璃瓶内备用;
(3)用时取鲜益母草10g、鲜大蓟10g、鲜小蓟10g、鲜桑叶6g、鲜菊花6g、鲜仙人掌6g,捣成泥状;
(4)取步骤(1)中制备的备用液1袋100ml、步骤(2)中制备的备用药粉1份和步骤(3)中捣成泥状的药泥,搅拌均匀,制成药膏。
本发明通过对病变的肩关节施以药膏外敷起到了清热解毒、活血化瘀、散寒通络、止痛生肌消肿的作用,可使受损的肩关节迅速消肿,恢复原有功能。TDP的照射对病变部位和药膏起到了加热的作用,可促进药物的渗透,增加药物的吸收量。药膏的镇痛作用使肢体的被动锻炼能够进行,促进了病变肩关节功能的迅速恢复。
本发明的有益效果:
1、标本兼治 它突破传统的治疗局限,能最大限度地调和气血,改善血液循环,促进和调整机体的免疫机能,调动人体内在的抗病能力,调整机体与外在环境的平衡,并调节人体的动态平衡,从整体上改善身体机能,达到治愈疾病的目的。
2、众药综治打破常规利用多种药物联合活血化瘀、通络镇痛、消肿、疏通病变部位的经络,促进新陈代谢,恢复病变部位的正常功能。迅速减轻病变肩关节痉挛、缺血、疼痛,从而缓解症状,治愈疾病。
具体实施方式
下面结合具体实施例对本发明作进一步说明:
对于粘连性肩关节囊炎的治疗,要在手法松解术解除粘连的基础上,尽快解决患者病变肩部的疼痛,阻断病情的进一步恶化;疏通病变部位的经络,改善血液循环,促进新陈代谢,恢复病变部位的正常功能;达到治愈疾病的目的。
实施例
本发明治疗粘连性肩关节囊炎外用中药药物,由以下中药原料按照以下重量配比制成:
土鳖虫100g、独活100g、续断100g、羌活150g、川芎100g、红花100g、防风100g、合欢皮100g、连翘120g、黄芩50g、板蓝根50g、千年健50g、威灵仙50g、桂枝50g、荆芥50g、醋制延胡索50g、全蝎50g、细辛50g、洋金花2g、赤石脂50g、自然铜30g、血竭10g、苏木50g、乳香50g、没药50g、炉甘石50g、儿茶50g、茜草50g、虎杖50g、黄药子50g、当归50g、天花粉10g、紫竹叶15g、鲜益母草10g、鲜大蓟10g、鲜小蓟10g、鲜桑叶6g、鲜菊花6g、鲜仙人掌6g。
本发明的制备工艺:本发明采用上等纯天然中草药的根茎、果实、种子经过清洗,烘干等工艺在无菌、无尘的条件下:
(1)将土鳖虫100g、独活100g、续断100g、羌活150g、川芎100g、红花100g、防风100g、合欢皮100g、连翘120g、黄芩50g、板蓝根50g、千年健50g、威灵仙50g、桂枝50g、荆芥50g浸泡于5000ml凉水中半小时,然后煎煮两次:第一次煎煮沸后20分钟,漉出煎液;第二次煎煮沸后10分钟,漉出煎液;然后合并两次煎液浓缩至1000ml,塑封于100ml的塑料袋内备用。
(2)将醋制延胡索50g、全蝎50g、细辛50g、洋金花2g、赤石脂50g、自然铜30g、血竭10g、苏木50g、乳香50g、没药50g、炉甘石50g、儿茶50g、茜草50g、虎杖50g、黄药子50g、当归50g、天花粉10g、紫竹叶15g混匀后碎成细粉,采用环氧乙烷灭菌后分成10等份装入无菌玻璃瓶内备用;
(3)鲜益母草10g、鲜大蓟10g、鲜小蓟10g、鲜桑叶6g、鲜菊花6g、鲜仙人掌6g,捣成泥状。
(4)用时取步骤(1)中制备的备用液1袋100ml、步骤(2)中制备的备用药粉1份和步骤(3)中捣成泥状的药泥,搅拌均匀,制成药膏。
使用方法:将本发明涂于擦洗干净的病变的肩关节并外附保鲜膜,每日早晚各涂药一次;每次涂药后以TDP神灯照射半小时,肩关节被动锻炼半小时,10天为一疗程。
本发明药理分析:
本发明原料中:合欢皮、续断、土鳖虫—活血祛瘀,消肿止痛,续筋骨;血竭、乳香、没药—活血止痛,消肿生肌;炉甘石、赤石脂、自然铜—清热、收湿敛疮;防风、独活、羌活 —通利关节,消肿止痛;茜草、虎杖、川芎、苏木、 红花、醋制延胡索—活血祛瘀,消肿止痛;桂枝、荆芥—温通经脉,通阳化气,止痛,止血;紫竹叶、黄药子、儿茶、鲜益母草—解毒消肿,活血化瘀;千年健、全蝎、当归—强筋骨,活血散结,消肿止痛;鲜大蓟、鲜小蓟、鲜仙人掌、鲜桑叶、鲜菊花、黄芩、天花粉、板蓝根、连翘、细辛-清热解毒,消肿散结;洋金花、威灵仙-解痉止痛。
1、活血祛瘀,消肿止痛,续筋骨:药物合欢皮、续断、土鳖虫病变的肩部其中的活性因子能迅速起到活血祛瘀,消肿止痛,续筋骨的作用。这五种药物还具有很好的杀菌,抗病毒加速受损部位新陈代谢,抗血栓形成,促进血液流动,促进病变部位迅速恢复。
2. 活血止痛,消肿生肌:药物血竭、乳香、没药中的活性因子能迅速起到活血止痛,消肿生肌的作用,这两种药物还具有多种抗菌素,所含的树脂、树胶、挥发油具有较强的镇痛作用。
3. 通利关节,消肿止痛:药物中的防风、独活、羌活均有很好的清热解毒,消肿止痛的作用,能促进神经胶质细胞的分裂和生长,通过影响神经内分泌功能,进而调节机体的生理病理活动,以达到消肿、通利关节的作用。
4. 清热、收湿敛疮:药物中的炉甘石、赤石脂、自然铜具有很好的清热,收湿敛疮的作用其中的活性成分,能吸着大量化学有害物或毒物而起到收敛、消炎、止痒及保护创面作用,并能抑制局部葡萄球菌的生长。
5. 活血祛瘀,消肿止痛:药物中的茜草、虎杖、川芎、苏木、 红花、醋制延胡索、鲜益母草具有活血祛瘀,消肿止痛的作用,其中的三萜类、皂苷、氨基酸、黄酮、糖和多种无机元素,具有抗疲劳、抗缺氧、免疫调节、疗疮痈,等作用。
6. 温通经脉,通阳化气,镇痛,抗炎,止血:药物中的桂枝、荆芥均有温通经脉,通阳化气的作用,其中的桂皮醛,酮类,烯类成分具有很强的镇痛,抗炎,止血的作用。
7. 解毒消肿,活血化瘀:药物中的紫竹叶、黄药子、儿茶、鲜益母草具有很强的解毒消肿,活血化瘀的作用,其中含有生物碱,非生物碱及20多种具有镇静、解痉、免疫调节、抗放射、抗肿瘤的有效成分。
8.活血散结,消肿止痉、痛:药物中的千年健、全蝎、当归能有效活血、散结、消肿止痉、止痛,千年健挥发油具有显著抑制布氏杆菌生长,治肢节酸疼的作用,全蝎中的蝎毒具有消肿止痉、镇痛的作用。当归挥发油有镇静、催眠、镇痛、麻醉等作用,当归对多种致病菌具有抗炎,还具有促进免疫的功能。
9. 清热解毒,消肿散结:药物中的鲜大蓟、鲜小蓟、鲜仙人掌、鲜桑叶、鲜菊花、黄芩、天花粉、板蓝根、连翘、细辛含有的多种生物碱,挥发油具有很强的清热解毒,消肿散结的作用;天花粉蛋白、癸酰乙醛、癸醛、月桂醛及甲壬酮等成分具有很强的清热解毒、消肿排脓的作用。
10. 解痉止痛:药物中的洋金花、威灵仙的有效成分如洋金花中的生物碱对病变部位具有麻醉,解痉,镇痛的作用,威灵仙为治疗痹痛拘挛麻木之要药。
本发明的药效学统计:
1.一般临床资料:选取同期入住我院普外科的粘连性肩关节囊炎患者214例,随机分为两组;治疗组107例,男44例,女63例;年龄21.47-79.42岁,平均59.31岁;实验组107例,男47例,女60例,年龄23.71-83.34岁,平均57.72岁;这两个随机组患者在性别、年龄、营养状况等方面比较,差异无统计学意义(P>0.05)。
2.使用方法:治疗组患者将病变的肩部给予手法松解术后,将药膏外涂擦洗干净的病变肩部并外附保鲜膜,每日早晚各一次;每次涂药后以TDP神灯照射半小时,肩关节被动锻炼半小时,10天为一疗程。对照组患者按照 传统的方法手法松解术后,局部痛点封闭,推拿、按摩10天为一疗程。
3.评价指标:比较两组患者出院时肩关节功能评分结果,治愈率,住院治疗的天数,出院时的满意度。(1)患者肩关节功能评定:采用周秉文主编的《颈肩痛》肩部活动功能评定指标,分别对术后6小时肩关节功能,出院时肩关节功能进行评分:总分为360分。极度受限0—60分,严重受限 60—120分,显著受限121-180分,中度受限181-240分,轻度受限241-300分,正常301-360分(2)临床疗效标准:痊愈:肩部疼痛消失,肩关节功能评分>300分,显效:肩部疼痛明显缓解,肩关节功能评分>240分;有效:肩部疼痛基本缓解,肩关节功能评分>180分;无效:肩部疼痛无改善,肩关节功能评分﹤180分。
4. 统计学方法:对两组患者的数量资料以 ±s表示,计数资料采用x2检验,p<0.05表示差异有统计学意义。
表1 两组患者出院时肩关节功能评分结果
注:与对照组比较x2=13.56 p<0.05有显著差异
表2两组患者临床治愈率比较
注:与对照组比较x2=9.56 p<0.05有显著差异
表3 两组患者住院治疗的天数(天)(±s)
表4两组患者出院时的满意度调查结果比较(%)
表注:与对照组比较x2=31.68 p<0.05有显著差异
5. 结果:治疗组患者出院时肩关节功能评分结果、治愈率、出院时的满意度明显高于对照组,患者住院治疗的天数,明显少于对照组,差异有统计学意义(P<0.05)。
本发明独特之处表现在:一是中药膏外敷起到了清热解毒,止痛消肿,活血化瘀,散寒通络的作用,可有效改善肩,关节肌肉的功能,促进病变部位的血液循环,使受损肩关节迅速止痛消肿恢,恢复原有功能;二是TDP的照射对病变部位和药膏起到了加热的作用,可促进药物的渗透,增加药物的吸收量。三是药膏能使有效的肢体功能锻炼得以进行,促进了病变肩关节功能的迅速恢复。
上面所述的实施例仅是对本发明的优选实施方式进行描述,并非对本发明的构思和保护范围进行限定,在不脱离本发明设计构思的前提下,本领域中普通工程技术人员对本发明的技术方案作出的各种变型和改进,均应落入本发明的保护范围。
Claims (1)
1.一种治疗粘连性肩关节囊炎的外用中药药物,其特征是,由以下中药原料按以下重量配比和以下制作方法制成:
土鳖虫100g、独活100g、续断100g、羌活150g、川芎100g、红花100g、防风100g、合欢皮100g、连翘120g、黄芩50g、板蓝根50g、千年健50g、威灵仙50g、桂枝50g、荆芥50g、醋制延胡索50g、全蝎50g、细辛50g、洋金花2g、赤石脂50g、自然铜30g、血竭10g、苏木50g、乳香50g、没药50g、炉甘石50g、儿茶50g、茜草50g、虎杖50g、黄药子50g、当归50g、天花粉10g、紫竹叶15g、鲜益母草10g、鲜大蓟10g、鲜小蓟10g、鲜桑叶6g、鲜菊花6g、鲜仙人掌6g;
其制备工艺为:将上述中草药的根茎、果实、种子经过清洗,烘干工艺,在无菌、无尘的条件下:
(1)将土鳖虫100g、独活100g、续断100g、羌活150g、川芎100g、红花100g、防风100g、合欢皮100g、连翘120g、黄芩50g、板蓝根50g、千年健50g、威灵仙50g、桂枝50g、荆芥50g浸泡于5000ml凉水中半小时,然后煎煮两次:第一次煎煮沸后20分钟,漉出煎液;第二次煎煮沸后10分钟,漉出煎液;然后合并两次煎液浓缩至1000ml,塑封于100ml的塑料袋内备用;
(2)将醋制延胡索50g、全蝎50g、细辛50g、洋金花2g、赤石脂50g、自然铜30g、血竭10g、苏木50g、乳香50g、没药50g、炉甘石50g、儿茶50g、茜草50g、虎杖50g、黄药子50g、当归50g、天花粉10g、紫竹叶15g混匀后碎成细粉,采用环氧乙烷灭菌后分成10等份装入无菌玻璃瓶内备用;
(3)用时取鲜益母草10g、鲜大蓟10g、鲜小蓟10g、鲜桑叶6g、鲜菊花6g、鲜仙人掌6g,捣成泥状;
(4)取步骤(1)中制备的备用液1袋100ml、步骤(2)中制备的备用药粉1份和步骤(3)中捣成泥状的药泥,搅拌均匀,制成药膏。
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