CN105816466A - Veterinary synchronized estrus promoter and preparation method thereof - Google Patents
Veterinary synchronized estrus promoter and preparation method thereof Download PDFInfo
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- CN105816466A CN105816466A CN201610154143.7A CN201610154143A CN105816466A CN 105816466 A CN105816466 A CN 105816466A CN 201610154143 A CN201610154143 A CN 201610154143A CN 105816466 A CN105816466 A CN 105816466A
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- animals
- estrus
- estrus synchronization
- synchronization agent
- altrenogest
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a veterinary synchronized estrus promoter. Each liter of the veterinary synchronized estrus promoter comprises the following raw materials by weight: 0.2 to 0.8 gram of altrenogest, 0.025 to 2 grams of sorbic acid, 0.07 to 11 grams of butyl hydroxyl anisole, 0.07 to 11 grams of 2,6-di-tert-butyl-4-methyl phenol, 1.2 to 1.7 grams of benzyl alcohol, and the balance being plant oil. The estrus promoter prepared from altrenogest, sorbic acid, butyl hydroxyl anisole, and 2,6-di-tert-butyl-4-methyl phenol can promote estrus and pregnancy, adjust the internal secretion of cattle, and control the regular estrus; thus the expected confinement of cattle in batches can be realized, pregnant cattle can be treated in batches, thus the production efficiency and industrial management level of farms can be greatly improved, and the pregnancy rate is 96% or more. The provided veterinary synchronized estrus promoter plays an important role for increasing the industrial production level of animal husbandry in our country.
Description
Technical field
The present invention relates to veterinary drug field, particularly relate to a kind of estrus synchronization agent for animals and preparation method thereof.
Background technology
If estrus synchronization drug main for animals irritates ovary by exogenous hormone so that it is send out according to predetermined requirement
Changing, makes the ovarian physiology function of process female animal all in same phase, thus reaches estrus synchronization.
Estrus synchronization generally uses two kinds of approach: a kind of approach is to extend luteal phase, uses to a group female animal simultaneously
Progestational hormone medicine, the growth promoter of suppression follicle and performance of oestrusing.Drug withdrawal simultaneously after the regular period, by
Lose the control of exogenous progestogen in ovary, the cycle corpus luteum on ovary is degenerated, goes out the most simultaneously simultaneously
Existing follicular development, causes female animal to oestrus.Use progestogen suppression female animal to send out lazy, actually artificially extend Huang
The body phase, play the effect extending the estrus cycle, postponing oestrus.Another kind of approach is to shorten luteal phase, should
Accelerating luteolysis with PGF2 α, make ovary break away from the control of internal progestogen in advance, then follicle is able to same
Shi Fayu, thus reach female animal estrus synchronization.This situation actually shortens the estrus cycle of female animal, promotees
Female animal is made to oestrus at short notice.The hormonal properties that above two approach uses is different, but is all to corpus luteum merit
Can play regulatory role, result makes extend luteal phase or shortens, and finally reaches the purpose of regulation ovarian function.
Cultivating factory on a large scale now, utilize estrus synchronization agent has sheep, cow etc., the method for employing
Mainly following three kinds of methods:
(1) vaginal suppository inserting method is by after sterilized to foam plastics, cotton-wool, and a certain amount of medicinal liquid is inhaled in leaching, fills in cervix uteri
Near, medicinal liquid slowly but discharges continuously to surrounding tissue, is absorbed by organisms, takes after certain time
Go out, be generally used for cattle, sheep.Advantage is a drug, saves trouble, and shortcoming is that first estrus conception rate is relatively low,
And easily there is thromboembolism obscission.
(2) heeling-in method: be contained in tubule with holes by medicine, is imbedded at subcutaneous, takes out through some days, the heeling-in phase
Between medicine slowly absorb, this method can be used as colony process.Dosage is little, is difficult to lose.
(3) injection: a certain amount of medicine is subcutaneously or intramuscularly injected by every day, drug withdrawal behind continuous some skies.
The greatest drawback of three of the above method is that breeding stock is caused stress, induces an illness, and is extremely difficult to
The control feelings effect of estrus synchronization, female animal pregnancy rate is many below 80%, is allowed to can not more effectively reach breeding stock
The mass of breeding, industrialization and reduction reproductive-cost.
Summary of the invention
In view of this, it is an object of the invention to provide a kind of estrus synchronization agent for animals, this agent of oestrusing can improve
The pregnancy rate of female animal.
To achieve these goals, the technical scheme is that
A kind of estrus synchronization agent for animals, comprises following raw material in every liter of estrus synchronization agent for animals:
Preferably, every liter of estrus synchronization agent for animals comprises following raw material:
Present invention also offers the preparation method of above-mentioned estrus synchronization agent for animals, comprise the following steps:
A) vegetable oil is poured in retort；
B) by altrenogest, sorbic acid, Butylated hydroxyanisole, 2,6 di tert butyl 4 methyl phenol and benzene
Methanol is sequentially added in the retort of step a), and heated and stirred, until each raw material is completely dissolved, i.e. obtains
Estrus synchronization agent for animals.
Preferably, heating-up temperature described in step b) is 25～35 DEG C, and described mixing time is 20～40min.
Preferably, also include after step b), estrus synchronization agent for animals is distributed into bottle, and below 25 DEG C
Store.
From technique scheme it can be seen that the present invention provide estrus synchronization agent for animals, by use allyl
Pregnant element, sorbic acid, Butylated hydroxyanisole and 2,6 di tert butyl 4 methyl phenol are oestrusing of preparing of raw material
Agent has promoting the sexual maturity of animals and promoting gravidity, regulates domestic animal endocrine, controls the effect that domestic animal periodically oestruses, it is possible to realize domestic animal
Packet is pre-produces, and reaches the purpose of all-in and all-out, thus production efficiency and the industrialization pipe of domestic animal field are greatly improved
Reason level, pregnancy rate is more than 96%.This serves act foot to the commercial production level improving China's farm
The effect of weight.
Detailed description of the invention
In order to further appreciate that the present invention, below in conjunction with embodiment, the preferred embodiments of the invention are retouched
State, but it is to be understood that these describe simply for further illustrating the features and advantages of the present invention rather than right
The restriction of patent requirements of the present invention.
A kind of estrus synchronization agent for animals, comprises following raw material in every liter of estrus synchronization agent for animals:
The estrus synchronization agent for animals that the present invention provides, will not cause stress, and effect is notable female animal,
Female animal can be made to reach " estrus synchronization, superfecundation, the same period teems, the same period delivers for sale " can oestrusing female animal
Rate, pregnancy rate bring up to more than 96%, greatly reduce cost of labor, it is achieved the industrialization of breeding stock breeding and
Scientific level, reduces reproductive-cost.Fundamentally improve the industrialized level of the breeding stock breeding of China, make
The breeding stock breeding technique of China is close to or up international breeding stock breeding level.
Altrenogest is the main component of animal contraception, in the present invention, wraps in every liter of estrus synchronization agent for animals
Containing 0.2～0.8g altrenogest；In an embodiment of the present invention, every liter of estrus synchronization agent for animals comprises
0.4～0.6g altrenogest.
Sorbic acid plays growing of suppression yeast, mycete and many funguses, and in the present invention, every liter for animals same
Phase oestruses and comprises 0.025～2g sorbic acid in agent；In an embodiment of the present invention, every liter of estrus synchronization agent for animals
In comprise 0.5～1.5g sorbic acid.
Butylated hydroxyanisole and 2,6-di-tert-butyl-4-methy phenol has synergism, plays antioxygen and is turned into
With, it is possible to extend the effect duration of estrus synchronization agent for animals.In the present invention, in every liter of estrus synchronization agent for animals
Comprise 0.07～11g Butylated hydroxyanisole；In an embodiment of the present invention, rise in estrus synchronization agent for animals and wrap
Containing 4～7g Butylated hydroxyanisole.
In the present invention, every liter of estrus synchronization agent for animals comprises the 2 of 0.07～11g, 6-di-t-butyl-4-methyl
Phenol；In an embodiment of the present invention, rise estrus synchronization agent for animals comprises 4～7g 2,6-di-t-butyl-4-
Methylphenol.
Benzyl alcohol plays the dissolving adding altrenogest, is allowed to reach most preferably to merge with other raw materials and vegetable oil
State, makes the effect of oestrusing of estrus synchronization agent for animals reach optimum state simultaneously.In the present invention, every liter
Estrus synchronization agent for animals comprises 1.2～1.7g benzyl alcohol；In an embodiment of the present invention, rise and send out the same period for animals
Feelings agent comprises 1.4～1.5g benzyl alcohol.
Present invention also offers the preparation method of a kind of estrus synchronization agent for animals, comprise the following steps:
A) vegetable oil is poured in retort；
B) by altrenogest, sorbic acid, Butylated hydroxyanisole, 2,6 di tert butyl 4 methyl phenol and benzene
Methanol is sequentially added in the retort of step a), and heated and stirred, until each raw material is completely dissolved, i.e. obtains
Estrus synchronization agent for animals.
The estrus synchronization agent for animals using technique scheme to prepare, has promoting the sexual maturity of animals and promoting gravidity, regulates domestic animal
Endocrine, controls the effect that domestic animal periodically oestruses, and to realize, domestic animal packet is pre-produces, and reaches the mesh of all-in and all-out
, thus production efficiency and the industrialization management level of domestic animal field are greatly improved, success rate is more than 96%.
The level of production improving China's farm is played the important and pivotal role by this.
In an embodiment of the present invention, in step b), heating-up temperature is 25～35 DEG C, and mixing time is
20～40min.
In an embodiment of the present invention, also include after step b), the estrus synchronization for animals that step b) is obtained
Agent subpackage such as duckweed, and store at 25 DEG C.
Present invention also offers the preparation of a kind of estrus synchronization agent for animals, this estrus synchronization agent for animals is oral liquid.
Female animal can be caused stress by above-mentioned oral agents, and effect is notable, and female animal can be made to reach, and " same period is sent out
Feelings, superfecundation, the same period teems, the same period delivers for sale " Oestrus rate of female animal, pregnancy rate can be brought up to 96%
Above, greatly reduce cost of labor, it is achieved the industrialization of breeding stock breeding and scientific level, reduce breeding
Cost.
The estrus synchronization agent for animals that the present invention provides, avoids and is used in mixed way with griseofulvin, be diagnosed as intrauterine
The female domestic animal disabling that film is scorching.
In order to further illustrate the present invention, below in conjunction with embodiment the present invention provided estrus synchronization agent for animals and
Its preparation method is described in detail, but they can not be interpreted as limiting the scope of the present invention.
Embodiment 1
Raw material is weighed: containing 0.2g altrenogest, 0.025g in every liter of estrus synchronization agent for animals by following weight
Sorbic acid, 0.07g Butylated hydroxyanisole, 0.07g2,6-di-tert-butyl-4-methy phenol and 1.2g benzyl alcohol,
Surplus is vegetable oil；
By above-mentioned altrenogest, sorbic acid, Butylated hydroxyanisole, 2,6 di tert butyl 4 methyl phenol, benzene
Methanol, is added sequentially to equipped with in the retort of vegetable oil, and stirs 35min at 30 DEG C, i.e. obtains beast
Use estrus synchronization agent, and estrus synchronization agent for animals is made oral liquid be distributed into bottle, and store at 25 DEG C.
Embodiment 2
Raw material is weighed: containing 0.8g altrenogest, 2g Pyrusussuriensis in every liter of estrus synchronization agent for animals by following weight
Acid, 7g Butylated hydroxyanisole, 7g2,6-di-tert-butyl-4-methy phenol and 1.4g benzyl alcohol, surplus is for planting
Thing oil；
By above-mentioned altrenogest, sorbic acid, Butylated hydroxyanisole, 2,6 di tert butyl 4 methyl phenol, benzene
Methanol, is added sequentially to equipped with in the retort of vegetable oil, and stirs 25min at 25 DEG C, i.e. obtains beast
Use estrus synchronization agent, and estrus synchronization agent for animals is made oral liquid be distributed into bottle, and store at 25 DEG C.
Embodiment 3
Raw material is weighed: containing 0.4g altrenogest, 1.5g mountain in every liter of estrus synchronization agent for animals by following weight
Pears acid, 4g Butylated hydroxyanisole, 4g2,6-di-tert-butyl-4-methy phenol and 1.5g benzyl alcohol, surplus is
Vegetable oil；
By above-mentioned altrenogest, sorbic acid, Butylated hydroxyanisole, 2,6 di tert butyl 4 methyl phenol, benzene
Methanol, is added sequentially to equipped with in the retort of vegetable oil, and stirs 35min at 35 DEG C, i.e. obtains beast
Use estrus synchronization agent, and estrus synchronization agent for animals is made oral liquid be distributed into bottle, and store at 20 DEG C.
Embodiment 4
Raw material is weighed: containing 0.6g altrenogest, 0.5g mountain in every liter of estrus synchronization agent for animals by following weight
Pears acid, 11g Butylated hydroxyanisole, 11g2,6-di-tert-butyl-4-methy phenol and 1.2g benzyl alcohol, surplus
For vegetable oil；
By above-mentioned altrenogest, sorbic acid, Butylated hydroxyanisole, 2,6 di tert butyl 4 methyl phenol, benzene
Methanol, is added sequentially to equipped with in the retort of vegetable oil, and stirs 25min at 35 DEG C, i.e. obtains beast
Use estrus synchronization agent, and estrus synchronization agent for animals is made oral liquid be distributed into bottle, and store at 20 DEG C.
Embodiment 5
Raw material is weighed: containing 0.5g altrenogest, 0.05g mountain in every liter of estrus synchronization agent for animals by following weight
Pears acid, 9g Butylated hydroxyanisole, 8g2,6-di-tert-butyl-4-methy phenol and 1.7g benzyl alcohol, surplus is
Vegetable oil；
By above-mentioned altrenogest, sorbic acid, Butylated hydroxyanisole, 2,6 di tert butyl 4 methyl phenol, benzene
Methanol, is added sequentially to equipped with in the retort of vegetable oil, and stirs 20min at 25 DEG C, i.e. obtains beast
Use estrus synchronization agent, and estrus synchronization agent for animals is made oral liquid be distributed into bottle, and store at 15 DEG C.
Embodiment 6
Raw material is weighed: containing 0.3g altrenogest, 0.1g mountain in every liter of estrus synchronization agent for animals by following weight
Pears acid, 0.5g Butylated hydroxyanisole, 0.4g2,6-di-tert-butyl-4-methy phenol and 1.3g benzyl alcohol, surplus
For vegetable oil；
By above-mentioned altrenogest, sorbic acid, Butylated hydroxyanisole, 2,6 di tert butyl 4 methyl phenol, benzene
Methanol, is added sequentially to equipped with in the retort of vegetable oil, and stirs 20min at 30 DEG C, i.e. obtains beast
Use estrus synchronization agent, and estrus synchronization agent for animals is made oral liquid be distributed into bottle, and store at 15 DEG C.
Embodiment 7
Raw material is weighed: containing 0.7g altrenogest, 0.5g mountain in every liter of estrus synchronization agent for animals by following weight
Pears acid, 1g Butylated hydroxyanisole, 0.1g2,6-di-tert-butyl-4-methy phenol and 1.6g benzyl alcohol, surplus
For vegetable oil；
By above-mentioned altrenogest, sorbic acid, Butylated hydroxyanisole, 2,6 di tert butyl 4 methyl phenol, benzene
Methanol, is added sequentially to equipped with in the retort of vegetable oil, and stirs 40min at 30 DEG C, i.e. obtains beast
Use estrus synchronization agent, and estrus synchronization agent for animals is made oral liquid be distributed into bottle, and store at 10 DEG C.
Embodiment 9
Raw material is weighed: containing 0.4g altrenogest, 0.3g mountain in every liter of estrus synchronization agent for animals by following weight
Pears acid, 0.1g Butylated hydroxyanisole, 0.3g2,6-di-tert-butyl-4-methy phenol and 1.2g benzyl alcohol, surplus
For vegetable oil；
By above-mentioned altrenogest, sorbic acid, Butylated hydroxyanisole, 2,6 di tert butyl 4 methyl phenol, benzene
Methanol, is added sequentially to equipped with in the retort of vegetable oil, and stirs 40min at 35 DEG C, i.e. obtains beast
Use estrus synchronization agent, and estrus synchronization agent for animals is made oral liquid be distributed into bottle, and store at 10 DEG C.
Embodiment 9
Raw material is weighed: containing 0.45g altrenogest, 1g mountain in every liter of estrus synchronization agent for animals by following weight
Pears acid, 3g Butylated hydroxyanisole, 2g2,6-di-tert-butyl-4-methy phenol and 1.7g benzyl alcohol, surplus is
Vegetable oil；
By above-mentioned altrenogest, sorbic acid, Butylated hydroxyanisole, 2,6 di tert butyl 4 methyl phenol, benzene
Methanol, is added sequentially to equipped with in the retort of vegetable oil, and stirs 30min at 25 DEG C, i.e. obtains beast
Use estrus synchronization agent, and estrus synchronization agent for animals is made oral liquid be distributed into bottle, and store at 5 DEG C.
Embodiment 10
Raw material is weighed: containing 0.55g altrenogest, 0.75g in every liter of estrus synchronization agent for animals by following weight
Sorbic acid, 6g Butylated hydroxyanisole, 5g2,6-di-tert-butyl-4-methy phenol and 1.45g benzyl alcohol, surplus
For vegetable oil；
By above-mentioned altrenogest, sorbic acid, Butylated hydroxyanisole, 2,6 di tert butyl 4 methyl phenol, benzene
Methanol, is added sequentially to equipped with in the retort of vegetable oil, and stirs 30min at 30 DEG C, i.e. obtains beast
Use estrus synchronization agent, and estrus synchronization agent for animals is made oral liquid be distributed into bottle, and store at 5 DEG C.
One, embodiment 1～10 being obtained estrus synchronization agent for animals to test, result is as follows:
1, experimenter selects: as a example by replacement gilt with also group sow, totally 330, all of sow is
First pregnant sow, and have performance of oestrusing 2～3 times.
2, packet design: all of sow is divided into 11 groups, respectively experimental group 1～10 and matched group, respectively
30,11 groups of sows, without significant difference, have comparability.
3, using method: control group fed normal diet；Experimental group 1～10 feeds sprinkling 5mL embodiment 1～10
The normal diet of estrus synchronization agent for animals；Matched group and experimental group 1～10 every day 1 time, feed 18 days altogether,
Disable 5 days again.
4, criterion
Experimental group and matched group pregnancy rate (pregnancy rate=sow number/30 of becoming pregnant).
5, result is as shown in table 1
Table 1 experimental group 1～10 and the experimental data of matched group
Above estrus synchronization agent a kind of for animals that the present invention provides and preparation method thereof is carried out detailed Jie
Continuing, principle and the embodiment of the present invention are set forth by specific case used herein, above enforcement
The explanation of example is only intended to help to understand method and the core concept thereof of the present invention, it is noted that for this skill
For the those of ordinary skill in art field, under the premise without departing from the principles of the invention, it is also possible to the present invention
Carrying out some improvement and modification, these improve and modify in the protection domain also falling into the claims in the present invention.
Claims (6)
1. an estrus synchronization agent for animals, it is characterised in that comprise the most former in every liter of estrus synchronization agent for animals
Material:
Estrus synchronization agent for animals the most as claimed in claim 1, it is characterised in that every liter of estrus synchronization for animals
Agent comprises following raw material:
The preparation method of estrus synchronization agent for animals the most as claimed in claim 1 or 2, it is characterised in that bag
Include following steps:
A) vegetable oil is poured in retort；
B) by altrenogest, sorbic acid, Butylated hydroxyanisole, 2,6 di tert butyl 4 methyl phenol and benzene
Methanol is sequentially added in the retort of step a), and heated and stirred, until each raw material is completely dissolved, i.e. obtains
Estrus synchronization agent for animals.
4. preparation method as claimed in claim 3, it is characterised in that heating-up temperature described in step b)
Being 25～35 DEG C, described mixing time is 20～40min.
5. preparation method as claimed in claim 3, it is characterised in that also include after step b), by beast
It is distributed into bottle with estrus synchronization agent, and stores below 25 DEG C.
6. the preparation of an estrus synchronization agent for animals, it is characterised in that by the beast described in claim 1 or 2
It is oral liquid with estrus synchronization agent.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610154143.7A CN105816466A (en) | 2016-03-17 | 2016-03-17 | Veterinary synchronized estrus promoter and preparation method thereof |
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| CN201610154143.7A CN105816466A (en) | 2016-03-17 | 2016-03-17 | Veterinary synchronized estrus promoter and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108042485A (en) * | 2017-11-08 | 2018-05-18 | 宁波三生生物科技有限公司 | A kind of Altrenogest preparation and preparation method thereof |
| CN109260208A (en) * | 2018-08-30 | 2019-01-25 | 宁波三生生物科技有限公司 | A kind of Altrenogest preparation for animals and preparation method thereof |
| CN109464400A (en) * | 2018-12-29 | 2019-03-15 | 佛山市南海东方澳龙制药有限公司 | Altrenogest solid pharmaceutical preparation and its preparation method and application |
| WO2023000418A1 (en) * | 2021-07-19 | 2023-01-26 | 宁波三生生物科技股份有限公司 | Altrenogest injection, preparation method therefor, and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5214035A (en) * | 1992-04-16 | 1993-05-25 | Hoechst-Roussel Agri-Vet Company | Thixotropic formulations |
-
2016
- 2016-03-17 CN CN201610154143.7A patent/CN105816466A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5214035A (en) * | 1992-04-16 | 1993-05-25 | Hoechst-Roussel Agri-Vet Company | Thixotropic formulations |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108042485A (en) * | 2017-11-08 | 2018-05-18 | 宁波三生生物科技有限公司 | A kind of Altrenogest preparation and preparation method thereof |
| CN108042485B (en) * | 2017-11-08 | 2018-11-27 | 宁波三生生物科技有限公司 | A kind of Altrenogest preparation and preparation method thereof |
| CN109260208A (en) * | 2018-08-30 | 2019-01-25 | 宁波三生生物科技有限公司 | A kind of Altrenogest preparation for animals and preparation method thereof |
| CN109260208B (en) * | 2018-08-30 | 2021-04-30 | 宁波三生生物科技有限公司 | Veterinary altrenogest preparation and preparation method thereof |
| CN109464400A (en) * | 2018-12-29 | 2019-03-15 | 佛山市南海东方澳龙制药有限公司 | Altrenogest solid pharmaceutical preparation and its preparation method and application |
| WO2023000418A1 (en) * | 2021-07-19 | 2023-01-26 | 宁波三生生物科技股份有限公司 | Altrenogest injection, preparation method therefor, and application thereof |
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