CN105816350A - Daily nail polish - Google Patents
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- CN105816350A CN105816350A CN201510469127.2A CN201510469127A CN105816350A CN 105816350 A CN105816350 A CN 105816350A CN 201510469127 A CN201510469127 A CN 201510469127A CN 105816350 A CN105816350 A CN 105816350A
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Abstract
The invention discloses a daily nail polish. The daily nail polish mainly comprises, by weight, 48.3 to 51.3 parts of water, 23 to 24 parts of polyurethane-35, 16.3 to 17 parts of acrylic acid/VP cross-linked polymer, 4.2 to 4.4 parts of hydroxypropyl methyl cellulose, 0.9 to 1.1 parts of triethanolamine, 0.7 to 0.8 part of laurinol polyoxyethylene ether and 0.01 to 0.05 part of a compound as shown in a formula I. The daily nail polish provided by the invention can be easily smeared and integrally stripped, so the daily nail polish can be easily replaced every day; the nail polish smeared on nails can be torn off before rest every night so as to allow the nails to have sufficient breathing time; and in the next day, a user can use different nail polish as needed so as to realize perfect matching among the color of the nail polish, clothes and make-up. The daily nail polish is prepared from purely natural raw materials, does not use any toxic raw material, protects nails and can effectively prevent and treat fungi.
Description
Technical field
The present invention relates to a kind of nial polish, relate more specifically to a kind of daily disposable and refer to coloured silk.
Background technology
On market, nial polish is various in style, riotous with colour.Especially at the beginning of spring Mo, summer, autumn, people seeking beauty often buys the nial polish of various kind, shades of colour, spreads upon fingernail or/and on toenail, with various clothing of arranging in pairs or groups, part personage also can go to special manicure shop to carry out nail decorative.
Traditional nial polish nial polish is substantially is this material with nitrocellulose, mixes the chemical solvents such as acetone, ethyl acetate, ethyl lactate, phthalic acid tincture class and makes.
In General nail oil, in order to reach the purpose making nial polish quickly parch, adding a large amount of acetone, ethyl acetate composition, the feature of both compositions is highly volatile, so nial polish can quickly be killed.But acetone, ethyl acetate belong to hazardous chemical, they are inflammable and explosive, when volatilization, generation is made us dazzling dizzy penetrating odor, room air is produced and stains (after volatilization, their volume will expand 1,000 times), in the case of long-term suction, nervous system may be produced harm, also mucosa is had strong and stimulating.As long as these nial polishs are coated with long, fingernail just breathes no more, and easily turns yellow, and pigment can be deposited in fingernail.
When nail polish colors to be changed or removal nial polish, needing to be impregnated with cleaner with cotton balls, by Cotton Gossypii by nail surface, wiping keeps the light pressure to nail surface simultaneously back and forth.Frequently use cleaner that fingernail is carried out, also fingernail can be damaged.
If some people seeking beauty goes to participate in friend's party, birthday party, the finger colour coloured silk generally smeared can be more bright-coloured, the occasion that the comparison of class of needing if had notice the when of attending a party temporarily promptly to go back such as to work is serious, loaded down with trivial details refers to the nial polish that color cleaning procedure can cause people cannot clean or change other colors the very first time, if not carrying out referring to color cleaning or replacing, it is clear that smear the most bright-coloured finger coloured silk and will seem that whole dressing is not suitable for.
It addition, the mycosis of fingernail (tinea unguium) belongs to infectious disease, the most still can not be treated satisfactorily.Although they great majority do not produce the pain sensation to patient, but being permanently present so that treatment has absolute necessity of infection focus.In addition to circulatory disturbance and damage, the factor of fungal infection of nail can be caused to also have immune defence to lack and some dysbolismus (diabetes).It is main infection object that toenail is particularly susceptible infection, thumb first and little finger first.And often apply nial polish, it is also possible to cause fungal infection.
Summary of the invention
The deficiency existed for prior art, it is an object of the invention to provide a kind of daily disposable and refer to coloured silk, can easily smear, it is also possible to realize flood and refer to color tearable peelable, without using cleaner to carry out the wiping to nial polish, every day can easily change the nial polish of different color according to dressing；If referring to coloured silk under peeling off every night, have employed the material composition of pure natural, without using any toxic raw materials, protecting fingernail, fungal infection can be prevented and treated simultaneously.
For achieving the above object, the technical scheme is that
A kind of daily disposable refers to coloured silk, it is characterised in that wrap the raw material of following weight portion:
Its compounds of formula I is shown below:
The glycerol of weight portion 0.09-1.2 can also be added as required；
Can also add the coloring agent of weight portion 0.01-4.2 as required, described coloring agent is the combination in any of at least two in CI12490, CI77891, CI11710, CI77266；
The Muscovitum of weight portion 2.58 can also be added as required.
The present invention so-called " as required ", refers to the different demand such as the color according to nial polish, glossiness, density, dry speed, and producer can regulate voluntarily.
The nial polish of the present invention is without materials such as acetone, toluene, formaldehyde, ethyl acetate, DBP, nontoxic, tasteless, to human body fanout free region, environmentally safe.
Prior art discloses the character of polyurethane-35, there is water proofing property and outstanding resistance to migration, the thin film of non-greasy can be formed, hardness and motility well balanced, can quickly become dry, wear-resisting, lasting, easily rinse, be the film former of a kind of generalization cosmetic formula, be suitable for broadness PH scope, without neutralizing, it it is a kind of low viscosity product；
Change General nail oil using NC Nitroncellulose as the mode of film former, but use polyurethane-35 and acrylic acid/VP cross linked polymer collectively as film former or perhaps interfacial agents, common effect both it result in rate of drying and and fingernail between attachment dynamics, peelable lay the foundation for tearable；
Hydroxypropyl methyl cellulose, as thickening agent, determines the viscosity of nial polish, can obtain when smearing nial polish stable, anti-settling, subtract ooze, the anti-performance such as drop down；
Triethanolamine is as buffer agent, it is possible to generate salt with mineral acid or organic acid reaction, for adjusting the pH value in solution；
Polyoxyethylene lauryl ether is as wetting agent, it it is one of kind minimum to skin irritation in surfactant, it with various surfactant compounds, can reduce their zest (can reduce the zest of triethanolamine in this formula), improves the performance of product；
Glycerol, as wetting agent, uses natural glycerin rather than industry glycerol in the present invention, fingernail is carried out moisturizing.
Water, polyurethane-35, acrylic acid/VP cross linked polymer, hydroxypropyl methyl cellulose, triethanolamine, the mutual fusion of each raw material such as polyoxyethylene lauryl ether, the especially proportioning of polyurethane-35 and acrylic acid/VP cross linked polymer determines tearable peelable, both hydroxypropyl methyl cellulose and triethanolamine coordinative role determines the thrown cycle of nial polish, because the formula that whole product is used only has triethanolamine slightly zest taste, and polyoxyethylene lauryl ether can effectively reduce the zest of triethanolamine, so that whole product nonirritant taste；Whole nial polish has good adhesive force and resistance to water, and paint film brightness is high, and bright in colour, colour retention is strong.
The nial polish of the present invention, after being applied on fingernail, drying time reaches at about 2-5 minute soon, coloured silk is referred to for daily disposable, user can be according to the nial polish of the mood of every day with dress collocation different colours, by peeling nial polish with hands tearing before having a bath every day, without cleaner, fingernail will not be caused any harm, can sufficiently be breathed at sack time fingernail.This nial polish of life-time service, the situation also not resulting in fingernail jaundice impaired occurs.
Embodiment
Below by embodiment, the invention will be further described.The method described in the embodiment of the present invention that it should be understood that is only used for the present invention rather than limitation of the present invention are described, under the concept thereof of the present invention, the simple modifications of preparation method of the present invention is broadly fallen into the scope of protection of present invention.All raw materials, solvent and the strain used in embodiment is purchased from Sigma Biochemical and Organic Compounds for Research and Diagnostic Clinical Reagents company.
In the cosmetics finished product query web that network address is http://www.cosdna.com/cht/ingredients.php, all the components of the input present invention, the degree of feeling at ease of its display single component is as shown in the table:
This website representing, the figure of degree of feeling at ease is shown with five kinds: The more representative on the left side more can feel at ease to use.This is a comprehensive safety index, from zest, cause pox different, its mainly for life-time service safety be estimated.Depending on including whether the data such as CIR (cosmetic composition comment) RTECS (chemical toxicity reaction information bank), FDA (Federal Food and Pharmaceutical management board) exist the report of this composition unfavorable.Its purpose is more prone to assess whether to cause the possibility of chronicity injury in skin, cell or human body.
Owing to the usage degree of feeling at ease that CI 11710 is yellow and CI 12490 is red is not the highest, both pigment can not be put into inside some color, as long as not allowing the support oil produced into both pigment, anemia of pregnant woman even can be allowed to feel at ease to use, the baby in anemia of pregnant woman or anemia of pregnant woman's belly will not be produced any injury.
The preparation embodiment of compound of formula I:
With Folium Ginkgo as raw material, pulverized and by soak with ethanol and extract 2～4 times, each 12h～72h, after being merged, filter and concentrate by extracting solution, obtained described Folium Ginkgo extract extractum；Wherein ethanol: Folium Ginkgo=3～4:1, weight ratio.
Dry column-packing after 60～120 mesh silica gel with 2～5 times of weight for described extractum after above-mentioned Folium Ginkgo extract extractum acetone solution are mixed, then it is followed successively by the grade chloroform-methanol solution of 9:1,8:2,7:3,6:4,5:5 by volume ratio and carries out gradient elution, the eluent obtained when collecting wherein with the chloroform-methanol eluting that volume ratio is 9:1, the referred to as first eluent；Continue to separate by above-mentioned first eluent silica gel column chromatography, the chloroform-acetone solution being followed successively by 15:1,10:1,5:1,2:1 by volume ratio carries out gradient elution, and the eluent obtained during by chloroform-acetone solution eluting that wherein volume is 10:1 is referred to as the second eluent.Continue to separate by above-mentioned second eluent silica gel column chromatography, the petroleum ether-ethyl acetate solution being followed successively by 9:1,8:2,7:3,6:4,5:5 by volume ratio carries out gradient elution, and the eluent obtained during by petroleum ether-ethyl acetate eluting that wherein volume ratio is 7:3 is referred to as the 3rd eluent.
Above-mentioned 3rd eluent being passed through high pressure liquid chromatography (pressure is at the reversed-phase preparative chromatography of 5-15Mpa) and carries out isolated and purified, this high pressure liquid chromatography uses 21.2mm × 250mm, the C of 5 μm18Chromatographic column, flowing is the methanol aqueous solution of 60wt% mutually, flow rate of mobile phase is 12mL/min, UV-detector detection wavelength is 374nm, 3rd each Jin Yang of eluent 60～150 μ L, collect eluent corresponding when chromatographic peak retention time after each sample introduction is 31min, after desolvation, i.e. obtain described compound of formula I
After obtaining above-mentioned compound of formula I, methanol solution can be again dissolved in, and with methanol solution for flowing phase, carry out chromatography by gel column, described compound of formula I can be purified further.
Formula I is yellow powder；The following key structural feature peak listing the ultraviolet spectra of compound of formula I, infrared spectrum and proton magnetic.
Ultraviolet spectra (solvent is methanol): λmax(log ε) 210 (4.36), 266 (3.82), 374 (3.68) nm；
Infrared spectrum (pressing potassium bromide troche): vmax3452,2924,2615,1668,1612,1516,1437,1316,1247,1182,1083,1022,868,722cm-1；
1H NMR(500MHz,CDCl3,ppm)δ:10.7(s-OH),9.48(s-OH)6.28-7.52(d,-CH 5H),6.57(s,1H),6.18(s 1H),3.27(d,-CH2),1.99-3.81(d,-CH39H).
Embodiment one:
A kind of daily disposable refers to coloured silk, nial polish for honey peach red color, including the water of 51.23 weight portions, the polyurethane-35 of 24.4 weight portions, the acrylic acid/VP cross linked polymer of 16.96 weight portions, the hydroxypropyl methyl cellulose of 4.35 weight portions, the triethanolamine of 1.03 weight portions, the polyoxyethylene lauryl ether of 0.78 weight portion, the compound of formula I of 0.01 weight portion, the glycerol of 0.25 weight portion, the CI77891 of 0.89 weight portion, the CI11710 of 0.02 weight portion, the CI12490 of 0.09 weight portion, high-speed stirred mix homogeneously after the mixing of above composition.
Embodiment two:
A kind of daily disposable refers to coloured silk, nial polish for positive red color, including the water of 49.74 weight portions, the polyurethane-35 of 23.87 weight portions, the acrylic acid/VP cross linked polymer of 16.63 weight portions, the hydroxypropyl methyl cellulose of 4.27 weight portions, the triethanolamine of 1.01 weight portions, the polyoxyethylene lauryl ether of 0.77 weight portion, the compound of formula I of 0.02 weight portion, the glycerol of 0.74 weight portion, the CI12490 of 2.97 weight portions, high-speed stirred mix homogeneously after the mixing of above composition.
Embodiment three:
A kind of daily disposable refers to coloured silk, nial polish for burgundy color, including the water of 48.36 weight portions, the polyurethane-35 of 23.45 weight portions, the acrylic acid/VP cross linked polymer of 16.66 weight portions, the hydroxypropyl methyl cellulose of 4.26 weight portions, the triethanolamine of 1.01 weight portions, the polyoxyethylene lauryl ether of 0.77 weight portion, the compound of formula I of 0.03 weight portion, the Muscovitum of 2.58 weight portions, the glycerol of 0.58 weight portion, the CI12490 of 0.09 weight portion, the CI77266 of 1.05 weight portions, high-speed stirred mix homogeneously after the mixing of above composition.
Embodiment four:
A kind of daily disposable refers to coloured silk, nial polish for bright cherry-red color, including the water of 49.51 weight portions, the polyurethane-35 of 23.74 weight portions, the acrylic acid/VP cross linked polymer of 16.57 weight portions, the hydroxypropyl methyl cellulose of 4.26 weight portions, the triethanolamine of 1 weight portion, the polyoxyethylene lauryl ether of 0.77 weight portion, the compound of formula I of 0.04 weight portion, the CI77891 of 0.68 weight portion, the CI12490 of 3.39 weight portions, the CI77266 of 0.08 weight portion, high-speed stirred mix homogeneously after the mixing of above composition.
Embodiment five:
A kind of daily disposable refers to coloured silk, nial polish for pink color, including the water of 51.19 weight portions, the polyurethane-35 of 24.56 weight portions, the acrylic acid/VP cross linked polymer of 16.73 weight portions, the hydroxypropyl methyl cellulose of 4.30 weight portions, the triethanolamine of 1.01 weight portions, the polyoxyethylene lauryl ether of 0.77 weight portion, the compound of formula I of 0.05 weight portion, the glycerol of 0.29 weight portion, the CI77891 of 0.93 weight portion, the CI12490 of 0.22 weight portion, high-speed stirred mix homogeneously after the mixing of above composition.
Embodiment six:
A kind of daily disposable refers to coloured silk, nial polish for light naked powder color, including the water of 51.21 weight portions, the polyurethane-35 of 24.78 weight portions, the acrylic acid/VP cross linked polymer of 16.89 weight portions, the hydroxypropyl methyl cellulose of 4.34 weight portions, the triethanolamine of 1.02 weight portions, the polyoxyethylene lauryl ether of 0.78 weight portion, the compound of formula I of 0.02 weight portion, the glycerol of 0.2 weight portion, the CI77891 of 0.75 weight portion, the CI11710 of 0.01 weight portion, the CI12490 of 0.02 weight portion, high-speed stirred mix homogeneously after the mixing of above composition.
Embodiment seven:
A kind of daily disposable refers to coloured silk, nial polish for honey peach red color, including the water of 48.99 weight portions, the polyurethane-35 of 23.44 weight portions, the acrylic acid/VP cross linked polymer of 16.36 weight portions, the hydroxypropyl methyl cellulose of 4.20 weight portions, the triethanolamine of 0.99 weight portion, the polyoxyethylene lauryl ether of 0.76 weight portion, the compound of formula I of 0.03 weight portion, the glycerol of 1.05 weight portions, the CI77891 of 4.17 weight portions, the CI12490 of 0.04 weight portion, high-speed stirred mix homogeneously after the mixing of above composition.
Table 1 is after the nial polish of above-described embodiment is applied on fingernail, goes to divest fingernail oil condition with hands:
| Drying time | Tearing degree | Drying time | Tearing degree | Drying time | Tearing degree | |
| Embodiment 1 | 2h | Viscous force is relatively strong, and fritter peels off | 5h | Part is still had to adhere to | 8h | Divest completely |
| Embodiment 2 | 2h | Viscous force is relatively strong, and fritter peels off | 5h | Part is still had to adhere to | 8h | Divest completely |
| Embodiment 3 | 2h | Viscous force is relatively strong, and fritter peels off | 5h | Part is still had to adhere to | 8h | Divest completely |
| Embodiment 4 | 2h | Viscous force is relatively strong, and fritter peels off | 5h | Part is still had to adhere to | 8h | Divest completely |
| Embodiment 5 | 2h | Viscous force is relatively strong, and fritter peels off | 5h | Part is still had to adhere to | 8h | Divest completely |
| Embodiment 6 | 2h | Viscous force is relatively strong, and fritter peels off | 5h | Part is still had to adhere to | 8h | Divest completely |
| Embodiment 7 | 2h | Viscous force is relatively strong, and fritter peels off | 5h | Part is still had to adhere to | 8h | Divest completely |
Activity experiment:
1, compound of formula I activity experiment
Being suspended in MH culture medium by antibacterial (trichophyton, trichophyton gypseum and Epidermophvton trichophyton), dispersion concentration is about 105Cfu mL-1, bacterium solution is added on 96 orifice plates (every hole adds bacterium solution 100 μ L), with culture medium as blank, using DMSO replacement tested material as negative control, with itraconazole (Xian-Janssen Pharmaceutical Ltd.) as positive control.Compound of formula I is dissolved in DMSO and is made into 800,400,200,100,50,25 μ g mL respectively-1Solution is (for MIC50Less than 5 μ g mL-1, when carrying out a step experiment, the Concentraton gradient of preparation is 50,25,12.5,6.25,3.1,1.5 μ g mL-1), join on 96 orifice plates with the amount of every hole 11 μ L that [ultimate density of medicinal liquid is respectively 80,40,20,10,5,2.5 μ g mL-1(it is 5,2.5,1.25,0.63,0.31 and 0.15 μ g mL for the latter-1)], each Concentraton gradient does four parallel laboratory tests.96 orifice plates are put into cultivation 24h in the incubator of 37 DEG C, then every hole adds the 25 every mL of the μ L PBS containing 4mg MTT, cultivating 4h again under similarity condition, every hole adds 100 μ LSDS lysates (95mL tri-distilled water+10gSDS+5mL isopropanol+0.1mL concentrated hydrochloric acid) and cultivates 12h afterwards.Measuring OD value under 570nm by microplate reader, percent inhibition is calculated as follows:
The height of activity is with semi-inhibit rate MIC50Represent, MIC50The least, the activity of compound is the highest, and result is: compound of formula I is to trichophyton, trichophyton gypseum and Epidermophvton trichophyton semi-inhibit rate MIC50It is respectively 0.63,0.60 and 0.82；Itraconazole is to trichophyton, trichophyton gypseum and Epidermophvton trichophyton semi-inhibit rate MIC50It is respectively 0.63,0.70 and 0.65.
2, agent activity experiment:
Use preparation described in embodiment 1-7, the activity experiment being discussed below:
Cutting about 0.5mm from the corner of Cornu Bovis seu Bubali thick, the small pieces of 1.5 × 3cm size also process half side, once a day, continuous five days with embodiment 1-7 preparation.Then being fixed on above the aqueous agar surface of a moisture chamber on the metal column of about 0.5cm by this sheet, the half side-view processed is down.The whole side of Cornu Bovis seu Bubali upward inoculates the microgonidium suspension of Trichophyton mentagrophytes in dots.Then, bacterium colony form is stored 10 days at 28 DEG C.
The pretreatment using the preparation of embodiment of the present invention 1-7 at half back side of Cornu Bovis seu Bubali prevents fungal spore for 5 times and germinates at whole end face.The most after 90 days, still vaccination can not be observed at whole apical view under the microscope.Therefore, the embodiment 1-7 preparation containing compound of formula I can the growth of effective pre-anti-fungal.
According to the method described above, carrying out control experiment, difference is in preparation described in embodiment 1-7 all not contain compound of formula I, and fungus has minority growing point on the Cornu Bovis seu Bubali side processed, but observed the good growth of fungus in another half.
Being provided without the blank of invention formulation process after inoculation, fungus fully grows on Cornu Bovis seu Bubali surface.
Claims (5)
1. a daily disposable refers to coloured silk, it is characterised in that include the raw material of following weight portion:
Its compounds of formula I is shown below:
Daily disposable the most according to claim 1 refers to coloured silk, it is characterised in that also include weight portion
The glycerol of 0.02-1.1.
Daily disposable the most according to claim 1 and 2 refers to coloured silk, it is characterised in that: also include
The coloring agent of weight portion 0.01-4.2.
Daily disposable the most according to claim 3 refers to coloured silk, it is characterised in that: described coloring agent
Red for CI12490, CI77891 is white, CI11710 is yellow, the black middle at least two of CI7726 any
Combination.
Daily disposable the most according to claim 4 refers to coloured silk, it is characterised in that also include 2.58
The Muscovitum of weight portion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510469127.2A CN105816350B (en) | 2015-08-03 | 2015-08-03 | Daily disposable refers to coloured silk |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510469127.2A CN105816350B (en) | 2015-08-03 | 2015-08-03 | Daily disposable refers to coloured silk |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105816350A true CN105816350A (en) | 2016-08-03 |
| CN105816350B CN105816350B (en) | 2018-04-10 |
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|---|---|---|---|
| CN201510469127.2A Active CN105816350B (en) | 2015-08-03 | 2015-08-03 | Daily disposable refers to coloured silk |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030064044A1 (en) * | 2001-04-16 | 2003-04-03 | Chen Shih-Ruey T. | Cosmetic compositions containing water-soluble polymer complexes |
| CN102228411A (en) * | 2011-06-23 | 2011-11-02 | 谭卓华 | Two-in-one water-soluble nail painting and protecting membrane solution |
| CN104758195A (en) * | 2014-01-06 | 2015-07-08 | 万华化学（广东）有限公司 | Waterborne nail polish based on aqueous polyurethane dispersion |
| CN104800125A (en) * | 2015-05-04 | 2015-07-29 | 上海零玖科技有限公司 | Nail polish and preparation method thereof |
-
2015
- 2015-08-03 CN CN201510469127.2A patent/CN105816350B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030064044A1 (en) * | 2001-04-16 | 2003-04-03 | Chen Shih-Ruey T. | Cosmetic compositions containing water-soluble polymer complexes |
| CN102228411A (en) * | 2011-06-23 | 2011-11-02 | 谭卓华 | Two-in-one water-soluble nail painting and protecting membrane solution |
| CN104758195A (en) * | 2014-01-06 | 2015-07-08 | 万华化学（广东）有限公司 | Waterborne nail polish based on aqueous polyurethane dispersion |
| CN104800125A (en) * | 2015-05-04 | 2015-07-29 | 上海零玖科技有限公司 | Nail polish and preparation method thereof |
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