CN105814202B - Notch1特异性sirna分子 - Google Patents

Notch1特异性sirna分子 Download PDF

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Publication number
CN105814202B
CN105814202B CN201480061599.8A CN201480061599A CN105814202B CN 105814202 B CN105814202 B CN 105814202B CN 201480061599 A CN201480061599 A CN 201480061599A CN 105814202 B CN105814202 B CN 105814202B
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nucleotide
nucleotides
nucleic acid
acid molecule
modified
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Expired - Fee Related
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CN105814202A (zh
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S·施赖伯
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Soluventis GmbH
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Soluventis GmbH
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
CN201480061599.8A 2013-09-30 2014-09-30 Notch1特异性sirna分子 Expired - Fee Related CN105814202B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202010081100.7A CN111197046A (zh) 2013-09-30 2014-09-30 Notch 1特异性sirna分子

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13004722.8 2013-09-30
EP13004722.8A EP2853595A1 (en) 2013-09-30 2013-09-30 NOTCH 1 specific siRNA molecules
PCT/EP2014/002655 WO2015043768A1 (en) 2013-09-30 2014-09-30 Notch 1 specific sirna molecule

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202010081100.7A Division CN111197046A (zh) 2013-09-30 2014-09-30 Notch 1特异性sirna分子

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CN105814202A CN105814202A (zh) 2016-07-27
CN105814202B true CN105814202B (zh) 2020-03-06

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CN201480061599.8A Expired - Fee Related CN105814202B (zh) 2013-09-30 2014-09-30 Notch1特异性sirna分子
CN202010081100.7A Pending CN111197046A (zh) 2013-09-30 2014-09-30 Notch 1特异性sirna分子

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CN202010081100.7A Pending CN111197046A (zh) 2013-09-30 2014-09-30 Notch 1特异性sirna分子

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EP (2) EP2853595A1 (enExample)
JP (2) JP6561061B2 (enExample)
CN (2) CN105814202B (enExample)
AU (1) AU2014327809B2 (enExample)
CA (1) CA2924788A1 (enExample)
DK (1) DK3052625T3 (enExample)
HR (1) HRP20211525T1 (enExample)
HU (1) HUE056609T2 (enExample)
IL (1) IL244661B (enExample)
LT (1) LT3052625T (enExample)
MX (1) MX377713B (enExample)
RU (1) RU2651493C2 (enExample)
SG (2) SG11201602437VA (enExample)
SI (1) SI3052625T1 (enExample)
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Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2853595A1 (en) * 2013-09-30 2015-04-01 Soluventis GmbH NOTCH 1 specific siRNA molecules
WO2021131944A1 (ja) * 2019-12-27 2021-07-01 国立大学法人神戸大学 癌遺伝子治療薬
CN112626068B (zh) * 2020-12-21 2021-12-03 徐州医科大学 一种靶向Notch1基因的LncRNA及其应用
CN116790603B (zh) * 2023-08-18 2023-10-31 成都中科奥格生物科技有限公司 一种sgRNA、CRISPR/Cas9载体及其构建方法和用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013020097A1 (en) * 2011-08-03 2013-02-07 Quark Pharmaceuticals, Inc. Double-stranded oligonucleotide compounds for treating hearing and balance disorders

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US5378825A (en) 1990-07-27 1995-01-03 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogs
EP0618925B2 (en) 1991-12-24 2012-04-18 Isis Pharmaceuticals, Inc. Antisense oligonucleotides
EP0786522A2 (en) 1992-07-17 1997-07-30 Ribozyme Pharmaceuticals, Inc. Enzymatic RNA molecules for treatment of stenotic conditions
US5753613A (en) 1994-09-30 1998-05-19 Inex Pharmaceuticals Corporation Compositions for the introduction of polyanionic materials into cells
US5885613A (en) 1994-09-30 1999-03-23 The University Of British Columbia Bilayer stabilizing components and their use in forming programmable fusogenic liposomes
US5820873A (en) 1994-09-30 1998-10-13 The University Of British Columbia Polyethylene glycol modified ceramide lipids and liposome uses thereof
US6001311A (en) 1997-02-05 1999-12-14 Protogene Laboratories, Inc. Apparatus for diverse chemical synthesis using two-dimensional array
US6395713B1 (en) 1997-07-23 2002-05-28 Ribozyme Pharmaceuticals, Inc. Compositions for the delivery of negatively charged molecules
EP1071753A2 (en) 1998-04-20 2001-01-31 Ribozyme Pharmaceuticals, Inc. Nucleic acid molecules with novel chemical compositions capable of modulating gene expression
CA2365625A1 (en) 1999-03-10 2000-09-14 Phogen Limited Delivery of substances to cells
PT1527176E (pt) 2002-08-05 2007-04-30 Atugen Ag Novas formas de muléculas de arn de interferência
SI1771206T1 (en) 2004-05-05 2018-06-29 Silence Therapeutics Gmbh LIPID LIPID COMPLEXES AND THEIR USE
BRPI0906657A2 (pt) * 2008-01-29 2015-07-14 Proyecto Biomedicina Cima Sl Métodos e composições capazes de causar um silenciamento pós-transcricional da expressão genética de forma sinérgica
WO2009114726A1 (en) * 2008-03-12 2009-09-17 Intradigm Corporation Compositions comprising notch1 sirna and methods of use thereof
EP2123256A1 (en) * 2008-05-19 2009-11-25 Ruhr-Universität Bochum Perfluorcarbon nanoemulsions with endocytosis enhancing surface for gene-transfer
EA201270019A1 (ru) * 2009-06-15 2012-06-29 Элнилэм Фармасьютикалз, Инк. Двуцепочечная рнк, включенная в липидный состав и мишенью которой является ген pcsk9
BR112014016937A2 (pt) * 2012-01-12 2017-06-13 Quark Pharmaceuticals Inc terapia de combinação para o tratamento de desordens de audição e do equilíbrio
EP2853595A1 (en) * 2013-09-30 2015-04-01 Soluventis GmbH NOTCH 1 specific siRNA molecules

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013020097A1 (en) * 2011-08-03 2013-02-07 Quark Pharmaceuticals, Inc. Double-stranded oligonucleotide compounds for treating hearing and balance disorders

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells;Zhiwei Wang等;《Mol Cancer Ther》;20060301;第5卷(第3期);第483-493页 *
小鼠胚胎干细胞Notch1基因沉默对Dvl-1和JNK-3表达的影响;李佳;《中国优秀硕士学位论文全文数据库（基础科学辑）》;20071115(第5期);A006-57 *

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MX2016004142A (es) 2016-10-13
CA2924788A1 (en) 2015-04-02
AU2014327809A1 (en) 2016-04-07
JP2016533190A (ja) 2016-10-27
JP6561061B2 (ja) 2019-08-14
MX377713B (es) 2025-03-11
SI3052625T1 (sl) 2021-12-31
US20180237785A1 (en) 2018-08-23
EP3052625B1 (en) 2021-08-25
US9896690B2 (en) 2018-02-20
RU2651493C2 (ru) 2018-04-19
SG10201802593WA (en) 2018-05-30
JP7086039B2 (ja) 2022-06-17
IL244661B (en) 2021-08-31
CN105814202A (zh) 2016-07-27
EP3052625A1 (en) 2016-08-10
WO2015043768A1 (en) 2015-04-02
RU2016116931A (ru) 2017-11-10
AU2014327809B2 (en) 2021-11-18
HUE056609T2 (hu) 2022-02-28
DK3052625T3 (da) 2021-11-15
SG11201602437VA (en) 2016-04-28
US20160215292A1 (en) 2016-07-28
EP2853595A1 (en) 2015-04-01
CN111197046A (zh) 2020-05-26
WO2015043768A8 (en) 2016-05-12
LT3052625T (lt) 2021-12-10
JP2019196384A (ja) 2019-11-14
IL244661A0 (en) 2016-04-21
US10669548B2 (en) 2020-06-02
HRP20211525T1 (hr) 2021-12-24

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