CN105796842A - Traditional Chinese medicine composition for treating periodontitis and preparation method of traditional Chinese medicine composition - Google Patents

Traditional Chinese medicine composition for treating periodontitis and preparation method of traditional Chinese medicine composition Download PDF

Info

Publication number
CN105796842A
CN105796842A CN201610131459.4A CN201610131459A CN105796842A CN 105796842 A CN105796842 A CN 105796842A CN 201610131459 A CN201610131459 A CN 201610131459A CN 105796842 A CN105796842 A CN 105796842A
Authority
CN
China
Prior art keywords
parts
chinese medicine
medicine composition
fructus
rhizoma
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201610131459.4A
Other languages
Chinese (zh)
Inventor
孙晓东
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201610131459.4A priority Critical patent/CN105796842A/en
Publication of CN105796842A publication Critical patent/CN105796842A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8964—Anemarrhena
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/238—Saposhnikovia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/268—Asarum (wild ginger)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/58—Meliaceae (Chinaberry or Mahogany family), e.g. Azadirachta (neem)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718—Coptis (goldthread)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A61K36/744—Gardenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a traditional Chinese medicine composition for treating periodontitis and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: 5-15 parts of asarum, 10-30 parts of honeysuckle, 10-30 parts of gardenia, 10-30 parts of rhizoma anemarrhenae, 5-15 parts of coptis chinensis, 5-15 parts of loofah sponge, 5-20 parts of moutan bark, 10-30 parts of mint, 10-30 parts of gypsum, 10-30 parts of divaricate saposhnikovia roots, 5-20 parts of liquorice, 10-30 parts of ligusticum, 10-45 parts of sandalwood, 10-28 parts of earthworm, 10-30 parts of pericarpium citri reticulatae viride, 10-30 parts of cortex meliae, 10-40 parts of semen lepidii and 25-50 parts of raspberry. The traditional Chinese medicine composition is prepared through the technologies of alcohol extraction, aqueous extraction and the like; and the composition has a good effect on treatment of gingival pain, gingival atrophy, teeth root leakage, gomphiasis and often errhysis and pyorrhea caused by stomach fire steaming.

Description

A kind of Chinese medicine composition treating periodontitis and preparation method thereof
Technical field
The present invention relates to field of medicine invention, be specifically related to a kind of Chinese medicine composition treating periodontitis and system thereof Preparation Method.
Background technology
The chronic inflammatory disease of the Periodontal Supporting Tissue that periodontitis is mainly caused by local factor, age of onset with 35 years old the most common, and clinical cardinal symptom is with gingiva pain, gum meat atrophy, root of the tooth a surname's dew, tooth Loosen, frequent oozing of blood pyorrhea is main.As gingivitis fails to treat in time, inflammation can be diffused into deep layer by gingiva Periodontal membrane, alveolar bone and cementum and develop into periodontitis.Due in early days many without obvious subjective symptoms easy quilt Ignore, the most more serious in time having symptom, the most can not retain tooth.Thus propaganda and education must be strengthened, make trouble Person's early presentation and in time treatment, lose the final result that tooth is untreated periodontitis.Inventor understands The certainly misery of periodontitis patient, the medicine little to health side effect, therefore have developed a kind of new drug.
Summary of the invention
It is an object of the invention to provide a kind of Chinese medicine composition treating periodontitis.
It is a further object of the present invention to provide a kind of preparation method treating periodontitis Chinese medicine composition.
It is a further object of the present invention to provide Chinese medicine composition described above and steam institute in preparation treatment stomach-fire The gingiva pain caused, gum meat atrophy, root of the tooth a surname's dew, odontoseisis, the application in the medicine of frequent oozing of blood pyorrhea.
The present invention provides a kind of Chinese medicine composition treating periodontitis, and this Chinese medicine composition is by following weight portion Chinese medicine is made: Herba Asari 5-15 part, Flos Lonicerae 10-30 part, Fructus Gardeniae 10-30 part, Rhizoma Anemarrhenae 10-30 part, Rhizoma Coptidis 5-15 part, Retinervus Luffae Fructus 5-15 part, Cortex Moutan 5-20 part, Herba Menthae 10-30 part, Gypsum Fibrosum 10-30 Part, Radix Saposhnikoviae 10-30 part, Radix Glycyrrhizae 5-20 part, Rhizoma Ligustici 10-30 part, Lignum Santali Albi 10-45 part, Pheretima 10-28 Part, Pericarpium Citri Reticulatae Viride 10-30 part, Cortex Meliae 10-30 part, Semen Lepidii (Semen Descurainiae) 10-40 part, Fructus Rubi 20-50 part.
Preferably, the Chinese medicine composition that the present invention provides is made up of the Chinese medicine of following weight portion: Herba Asari 7-13 Part, Flos Lonicerae 12-25 part, Fructus Gardeniae 12-25 part, Rhizoma Anemarrhenae 12-28 part, Rhizoma Coptidis 7-13 part, Retinervus Luffae Fructus 7-13 part, Cortex Moutan 7-18 part, Herba Menthae 12-28 part, Gypsum Fibrosum 12-28 part, Radix Saposhnikoviae 12-28 part, sweet Grass 7-18 part, Rhizoma Ligustici 12-28 part, Lignum Santali Albi 15-40 part, Pheretima 12-26 part, Pericarpium Citri Reticulatae Viride 12-28 part, Cortex Meliae 12-28 part, Semen Lepidii (Semen Descurainiae) 15-35 part, Fructus Rubi 25-45 part.
It is further preferred that the Chinese medicine composition that the present invention provides is made up of the Chinese medicine of following weight portion: Herba Asari 9-11 part, Flos Lonicerae 15-22 part, Fructus Gardeniae 15-22 part, Rhizoma Anemarrhenae 15-22 part, Rhizoma Coptidis 9-11 part, silk Melon network 9-11 part, Cortex Moutan 9-16 part, Herba Menthae 15-25 part, Gypsum Fibrosum 15-25 part, Radix Saposhnikoviae 15-25 Part, Radix Glycyrrhizae 9-15 part, Rhizoma Ligustici 15-25 part, Lignum Santali Albi 20-35 part, Pheretima 15-24 part, Pericarpium Citri Reticulatae Viride 14-26 Part, Cortex Meliae 14-26 part, Semen Lepidii (Semen Descurainiae) 18-32 part, Fructus Rubi 28-42 part.
Further preferred, the Chinese medicine composition that the present invention provides is made up of the Chinese medicine of following weight portion: thin Pungent 10 parts, Flos Lonicerae 18 parts, Fructus Gardeniae 18 parts, the Rhizoma Anemarrhenae 18 parts, Rhizoma Coptidis 10 parts, Retinervus Luffae Fructus 10 parts, Cortex Moutan 13 parts, Herba Menthae 20 parts, 20 parts of Gypsum Fibrosum, Radix Saposhnikoviae 20 parts, 12 parts of Radix Glycyrrhizae, Rhizoma Ligustici 20 parts, 25 parts of Lignum Santali Albi, Pheretima 20 parts, 20 parts of Pericarpium Citri Reticulatae Viride, Cortex Meliae 20 parts, Semen Lepidii (Semen Descurainiae) 25 parts, Fructus Rubi 35 parts.
The preparation method of Chinese medicine composition of the present invention comprises the following steps: Herba Asari, Flos Lonicerae, Fructus Gardeniae, The Rhizoma Anemarrhenae, Rhizoma Coptidis, Retinervus Luffae Fructus, Cortex Moutan, Herba Menthae, Gypsum Fibrosum, Radix Saposhnikoviae, Radix Glycyrrhizae, Rhizoma Ligustici, Lignum Santali Albi, Pheretima, Pericarpium Citri Reticulatae Viride, Cortex Meliae, Semen Lepidii (Semen Descurainiae), Fructus Rubi pulverize and sieve, and mix with pharmaceutically acceptable carrier or diluent Close uniformly, be prepared as preparation.
The preparation method of Chinese medicine composition of the present invention comprises the following steps:
1) Chinese medicine of weight portion is weighed respectively, standby；
2) Retinervus Luffae Fructus, Cortex Moutan are added 2-5 times amount water soaking 12-24 hour, filter, filtrate concentrate drying, It is ground into fine powder, standby；Filtering residue adds ethanol 2-4 times amount heating and refluxing extraction 2-4 time of 60-90%, each 1-3 Hour, filter, filtrate recycling ethanol, dry, pulverize into fine powder, standby.
3) by Herba Asari, Flos Lonicerae, Fructus Gardeniae, the Rhizoma Anemarrhenae, Rhizoma Coptidis, Herba Menthae, Gypsum Fibrosum, Radix Saposhnikoviae, Radix Glycyrrhizae, ligusticumic Basis, Lignum Santali Albi, Pheretima, Pericarpium Citri Reticulatae Viride, Cortex Meliae, Semen Lepidii (Semen Descurainiae), Fructus Rubi add water 3-5 times amount, decoct 3-5 time, 1-3 hour every time, collecting decoction, filter, filtrate concentrates, and dry, pulverize into fine powder, standby；
4) by step 2) 3) fine powder mix homogeneously, add pharmaceutically acceptable carrier or diluent system Dosage form needed for one-tenth.
Preferably, the preparation method of Chinese medicine composition of the present invention comprises the following steps:
1) Chinese medicine of weight portion is weighed respectively, standby；
2) Retinervus Luffae Fructus, Cortex Moutan are added 3 times amount water soaking 18 hours, filter, filtrate concentrate drying, pulverize Become fine powder, standby；The ethanol 3 times amount heating and refluxing extraction that filtering residue adds 75% 3 times, each 2 hours, filters, Filtrate recycling ethanol, dry, pulverize into fine powder, standby.
3) by Herba Asari, Flos Lonicerae, Fructus Gardeniae, the Rhizoma Anemarrhenae, Rhizoma Coptidis, Herba Menthae, Gypsum Fibrosum, Radix Saposhnikoviae, Radix Glycyrrhizae, ligusticumic Basis, Lignum Santali Albi, Pheretima, Pericarpium Citri Reticulatae Viride, Cortex Meliae, Semen Lepidii (Semen Descurainiae), Fructus Rubi add water 4 times amount, decoct 4 times, every time 2 hours, collecting decoction, filter, filtrate concentrates, and dry, pulverize into fine powder, standby；
4) by step 2) 3) fine powder mix homogeneously, add pharmaceutically acceptable carrier or diluent system Dosage form needed for one-tenth.
Described parts by weight can be unit of weight known to the field of medicaments such as μ g, mg, g, kg.
The implication of times amount refers to the weight ratio of medical material.
The Chinese medicine composition that the present invention provides is possibly together with pharmaceutically acceptable carrier or diluent.
Described Chinese medicine composition is solid preparation or liquid preparation, described solid preparation be tablet, capsule, Granule or pill；Described liquid preparation is oral liquid.
Described pharmaceutically acceptable carrier or diluent refer to the pharmaceutical carrier that pharmaceutical field is conventional, selected from filling out Fill one or more in agent, binding agent, disintegrating agent, lubricant, surfactant or correctives.
Wherein said filler is selected from starch, sucrose, lactose, mannitol, sorbitol, xylitol, crystallite Cellulose or glucose etc.；
Described binding agent is selected from cellulose derivative, alginate, gelatin or polyvinylpyrrolidone etc.；
Described disintegrating agent is selected from microcrystalline Cellulose, carboxymethyl starch sodium, polyvinylpyrrolidone, low replacement hydroxyl Propyl cellulose or cross-linking sodium carboxymethyl cellulose；
Described lubricant is selected from stearic acid, Polyethylene Glycol, calcium carbonate, sodium bicarbonate, silicon dioxide, Talcum Powder or magnesium stearate；
Described surfactant is common selected from dodecylbenzene sodium sulfonate, stearic acid, PULLRONIC F68 Polymers, fatty acid Pyrusussuriensis be smooth or Polysorbate (tween) etc.；
Described correctives is selected from aspartame, Sucralose or saccharin sodium.
The Chinese medicine composition that the present invention provides has the advantage that
1, act on obvious, rapid-action, have no side effect.
2, the present invention by pharmacodynamics test data show described in Chinese medicine composition there is analgesia, antiinflammatory Effect, the capillary permeability causing inflammation caused by each medication group xylol increases and dyestuff oozes out all There is the strongest inhibitory action, cure mainly the most identical with the function of the present invention, provide pharmacology for clinical trial Learn foundation.
Detailed description of the invention
Following example are used for illustrating the present invention, but are not limited to the scope of the present invention.
Embodiment 1
Prescription: Herba Asari 5g, Flos Lonicerae 10g, Fructus Gardeniae 10g, Rhizoma Anemarrhenae 10g, Rhizoma Coptidis 5g, Retinervus Luffae Fructus 5g, Cortex Moutan 5g, Herba Menthae 10g, Gypsum Fibrosum 10g, Radix Saposhnikoviae 10g, Radix Glycyrrhizae 5g, Rhizoma Ligustici 10g, Lignum Santali Albi 10g, Pheretima 10g, Pericarpium Citri Reticulatae Viride 10g, Cortex Meliae 10g, Semen Lepidii (Semen Descurainiae) 10g, Fructus Rubi 20g.
Preparation method:
1) Chinese medicine of weight portion is weighed respectively, standby；
2) Retinervus Luffae Fructus, Cortex Moutan are added 2 times amount water soaking 12 hours, filter, filtrate concentrate drying, pulverize Become fine powder, standby；The ethanol 2 times amount heating and refluxing extraction that filtering residue adds 60% 2 times, each 1 hour, filters, Filtrate recycling ethanol, dry, pulverize into fine powder, standby.
3) by Herba Asari, Flos Lonicerae, Fructus Gardeniae, the Rhizoma Anemarrhenae, Rhizoma Coptidis, Herba Menthae, Gypsum Fibrosum, Radix Saposhnikoviae, Radix Glycyrrhizae, ligusticumic Basis, Lignum Santali Albi, Pheretima, Pericarpium Citri Reticulatae Viride, Cortex Meliae, Semen Lepidii (Semen Descurainiae), Fructus Rubi add water 3 times amount, decoct 3 times, every time 1 hour, collecting decoction, filter, filtrate concentrates, and dry, pulverize into fine powder, standby；
4) by step 2) 3) fine powder mix homogeneously, add and account for the starch of mix homogeneously fine powder weight 2/5, Load capsule, make capsule.
Embodiment 2
Prescription: Herba Asari 15g, Flos Lonicerae 30g, Fructus Gardeniae 30g, Rhizoma Anemarrhenae 30g, Rhizoma Coptidis 15g, Retinervus Luffae Fructus 15g, Cortex Moutan 20g, Herba Menthae 30g, Gypsum Fibrosum 30g, Radix Saposhnikoviae 30g, Radix Glycyrrhizae 20g, Rhizoma Ligustici 30g, Lignum Santali Albi 45g, Pheretima 28g, Pericarpium Citri Reticulatae Viride 30g, Cortex Meliae 30g, Semen Lepidii (Semen Descurainiae) 40g, Fructus Rubi 50g.
Preparation method:
1) Chinese medicine of weight portion is weighed respectively, standby；
2) Retinervus Luffae Fructus, Cortex Moutan are added 5 times amount water soaking 24 hours, filter, filtrate concentrate drying, pulverize Become fine powder, standby；The ethanol 4 times amount heating and refluxing extraction that filtering residue adds 90% 4 times, each 3 hours, filters, Filtrate recycling ethanol, dry, pulverize into fine powder, standby.
3) by Herba Asari, Flos Lonicerae, Fructus Gardeniae, the Rhizoma Anemarrhenae, Rhizoma Coptidis, Herba Menthae, Gypsum Fibrosum, Radix Saposhnikoviae, Radix Glycyrrhizae, ligusticumic Basis, Lignum Santali Albi, Pheretima, Pericarpium Citri Reticulatae Viride, Cortex Meliae, Semen Lepidii (Semen Descurainiae), Fructus Rubi add water 5 times amount, decoct 5 times, every time 3 hours, collecting decoction, filter, filtrate concentrates, and dry, pulverize into fine powder, standby；
4) by step 2) 3) fine powder mix homogeneously, add and account for the starch of mix homogeneously fine powder weight 2/5, Load capsule, make capsule.
Embodiment 3
Prescription: Herba Asari 7g, Flos Lonicerae 12g, Fructus Gardeniae 12g, Rhizoma Anemarrhenae 12g, Rhizoma Coptidis 7g, Retinervus Luffae Fructus 7g, Cortex Moutan 7g, Herba Menthae 12g, Gypsum Fibrosum 12g, Radix Saposhnikoviae 12g, Radix Glycyrrhizae 7g, Rhizoma Ligustici 12g, Lignum Santali Albi 15g, Pheretima 12g, Pericarpium Citri Reticulatae Viride 12g, Cortex Meliae 12g, Semen Lepidii (Semen Descurainiae) 15g, Fructus Rubi 25g.
Preparation method:
1) Chinese medicine of weight portion is weighed respectively, standby；
2) Retinervus Luffae Fructus, Cortex Moutan are added 3 times amount water soaking 18 hours, filter, filtrate concentrate drying, pulverize Become fine powder, standby；The ethanol 3 times amount heating and refluxing extraction that filtering residue adds 75% 3 times, each 2 hours, filters, Filtrate recycling ethanol, dry, pulverize into fine powder, standby.
3) by Herba Asari, Flos Lonicerae, Fructus Gardeniae, the Rhizoma Anemarrhenae, Rhizoma Coptidis, Herba Menthae, Gypsum Fibrosum, Radix Saposhnikoviae, Radix Glycyrrhizae, ligusticumic Basis, Lignum Santali Albi, Pheretima, Pericarpium Citri Reticulatae Viride, Cortex Meliae, Semen Lepidii (Semen Descurainiae), Fructus Rubi add water 4 times amount, decoct 4 times, every time 2 hours, collecting decoction, filter, filtrate concentrates, and dry, pulverize into fine powder, standby；
4) by step 2) 3) fine powder mix homogeneously, add and account for the starch of mix homogeneously fine powder weight 1/5, Mixing, pelletizes, and is dried, granulate, obtains the granule of the application.
Embodiment 4
Prescription: Herba Asari 13g, Flos Lonicerae 15g, Fructus Gardeniae 25g, Rhizoma Anemarrhenae 28g, Rhizoma Coptidis 13g, Retinervus Luffae Fructus 13g, Cortex Moutan 18g, Herba Menthae 28g, Gypsum Fibrosum 28g, Radix Saposhnikoviae 28g, Radix Glycyrrhizae 18g, Rhizoma Ligustici 28g, Lignum Santali Albi 40g, Pheretima 26g, Pericarpium Citri Reticulatae Viride 28g, Cortex Meliae 28g, Semen Lepidii (Semen Descurainiae) 35g, Fructus Rubi 45g.
Preparation method:
1) Chinese medicine of weight portion is weighed respectively, standby；
2) Retinervus Luffae Fructus, Cortex Moutan are added 3 times amount water soaking 18 hours, filter, filtrate concentrate drying, pulverize Become fine powder, standby；The ethanol 3 times amount heating and refluxing extraction that filtering residue adds 75% 3 times, each 2 hours, filters, Filtrate recycling ethanol, dry, pulverize into fine powder, standby.
3) by Herba Asari, Flos Lonicerae, Fructus Gardeniae, the Rhizoma Anemarrhenae, Rhizoma Coptidis, Herba Menthae, Gypsum Fibrosum, Radix Saposhnikoviae, Radix Glycyrrhizae, ligusticumic Basis, Lignum Santali Albi, Pheretima, Pericarpium Citri Reticulatae Viride, Cortex Meliae, Semen Lepidii (Semen Descurainiae), Fructus Rubi add water 4 times amount, decoct 4 times, every time 2 hours, collecting decoction, filter, filtrate concentrates, and dry, pulverize into fine powder, standby；
4) by step 2) 3) fine powder mix homogeneously, add and account for the starch of mix homogeneously fine powder weight 1/5, It is dried, tabletting, obtains the tablet of the application.
Embodiment 5
Prescription: Herba Asari 9g, Flos Lonicerae 15g, Fructus Gardeniae 15g, Rhizoma Anemarrhenae 15g, Rhizoma Coptidis 9g, Retinervus Luffae Fructus 9g, Cortex Moutan 9g, Herba Menthae 15g, Gypsum Fibrosum 15g, Radix Saposhnikoviae 15g, Radix Glycyrrhizae 9g, Rhizoma Ligustici 15g, Lignum Santali Albi 20g, Pheretima 15g, Pericarpium Citri Reticulatae Viride 14g, Cortex Meliae 14g, Semen Lepidii (Semen Descurainiae) 18g, Fructus Rubi 28g.
Preparation method:
1) Chinese medicine of weight portion is weighed respectively, standby；
2) Retinervus Luffae Fructus, Cortex Moutan are added 3 times amount water soaking 18 hours, filter, filtrate concentrate drying, pulverize Become fine powder, standby；The ethanol 3 times amount heating and refluxing extraction that filtering residue adds 75% 3 times, each 2 hours, filters, Filtrate recycling ethanol, dry, pulverize into fine powder, standby.
3) by Herba Asari, Flos Lonicerae, Fructus Gardeniae, the Rhizoma Anemarrhenae, Rhizoma Coptidis, Herba Menthae, Gypsum Fibrosum, Radix Saposhnikoviae, Radix Glycyrrhizae, ligusticumic Basis, Lignum Santali Albi, Pheretima, Pericarpium Citri Reticulatae Viride, Cortex Meliae, Semen Lepidii (Semen Descurainiae), Fructus Rubi add water 4 times amount, decoct 4 times, every time 2 hours, collecting decoction, filter, filtrate concentrates, and dry, pulverize into fine powder, standby；
4) by step 2) 3) fine powder mix homogeneously, add 3 times amount aquesterilisa, filter, add account for filter The aspartame of liquid 1/8, perfusion, gland, sterilizing, obtain the oral liquid of the application.
Embodiment 6
Prescription: Herba Asari 11g, Flos Lonicerae 22g, Fructus Gardeniae 22g, Rhizoma Anemarrhenae 22g, Rhizoma Coptidis 11g, Retinervus Luffae Fructus 11g, Cortex Moutan 16g, Herba Menthae 25g, Gypsum Fibrosum 25g, Radix Saposhnikoviae 25g, Radix Glycyrrhizae 15g, Rhizoma Ligustici 25g, Lignum Santali Albi 35g, Pheretima 24g, Pericarpium Citri Reticulatae Viride 26g, Cortex Meliae 26g, Semen Lepidii (Semen Descurainiae) 32g, Fructus Rubi 42g.
Preparation method:
1) Chinese medicine of weight portion is weighed respectively, standby；
2) Retinervus Luffae Fructus, Cortex Moutan are added 3 times amount water soaking 18 hours, filter, filtrate concentrate drying, pulverize Become fine powder, standby；The ethanol 3 times amount heating and refluxing extraction that filtering residue adds 75% 3 times, each 2 hours, filters, Filtrate recycling ethanol, dry, pulverize into fine powder, standby.
3) by Herba Asari, Flos Lonicerae, Fructus Gardeniae, the Rhizoma Anemarrhenae, Rhizoma Coptidis, Herba Menthae, Gypsum Fibrosum, Radix Saposhnikoviae, Radix Glycyrrhizae, ligusticumic Basis, Lignum Santali Albi, Pheretima, Pericarpium Citri Reticulatae Viride, Cortex Meliae, Semen Lepidii (Semen Descurainiae), Fructus Rubi add water 4 times amount, decoct 4 times, every time 2 hours, collecting decoction, filter, filtrate concentrates, and dry, pulverize into fine powder, standby；
4) by step 2) 3) fine powder mix homogeneously, add 3 times amount aquesterilisa, filter, addition accounts for The dextrin of mix homogeneously fine powder weight 1/13, mixing, pill, it is dried, obtains the micropill of the application.
Embodiment 7
Prescription: Herba Asari 10g, Flos Lonicerae 18g, Fructus Gardeniae 18g, Rhizoma Anemarrhenae 18g, Rhizoma Coptidis 10g, Retinervus Luffae Fructus 10g, Cortex Moutan 13g, Herba Menthae 20g, Gypsum Fibrosum 20g, Radix Saposhnikoviae 20g, Radix Glycyrrhizae 12g, Rhizoma Ligustici 20g, Lignum Santali Albi 25g, Pheretima 20g, Pericarpium Citri Reticulatae Viride 20g, Cortex Meliae 20g, Semen Lepidii (Semen Descurainiae) 25g, Fructus Rubi 35g.
Preparation method:
1) Chinese medicine of weight portion is weighed respectively, standby；
2) Retinervus Luffae Fructus, Cortex Moutan are added 3 times amount water soaking 18 hours, filter, filtrate concentrate drying, pulverize Become fine powder, standby；The ethanol 3 times amount heating and refluxing extraction that filtering residue adds 75% 3 times, each 2 hours, filters, Filtrate recycling ethanol, dry, pulverize into fine powder, standby.
3) by Herba Asari, Flos Lonicerae, Fructus Gardeniae, the Rhizoma Anemarrhenae, Rhizoma Coptidis, Herba Menthae, Gypsum Fibrosum, Radix Saposhnikoviae, Radix Glycyrrhizae, ligusticumic Basis, Lignum Santali Albi, Pheretima, Pericarpium Citri Reticulatae Viride, Cortex Meliae, Semen Lepidii (Semen Descurainiae), Fructus Rubi add water 4 times amount, decoct 4 times, every time 2 hours, collecting decoction, filter, filtrate concentrates, and dry, pulverize into fine powder, standby；
4) by step 2) 3) fine powder mix homogeneously, add and account for the plant of mix homogeneously fine powder weight 1/9 Oil mixing, obtains the soft capsule of the application.
In order to further illustrate beneficial effects of the present invention, inventor has done pharmacology test.
1. the impact on hot-plate instrument induction mice vola pain model
1.1 animal packets
Female mice 50 being only randomly divided into 5 groups, often group 10, respectively model group, present invention height are (about 0.12g/ml), (about 0.06g/ml), low (about 0.03g/ml) dosage group, positive drug control group in (spasmolysis and analgesia tincture, 0.12g/ml).
1.2 experimental technique
Mice adaptability is fed two days later, and model group gavages administration with normal saline 2ml/kg；Spasmolysis and analgesia Tincture group gavages administration by 2ml/kg, one day 3 times, continuous use 2 days；High dose of the present invention, middle dosage, Low dose group all gavages administration by 2ml/kg, one day 3 times, continuous use 2 days.Before medication, by mice Being placed on hot plate box, control temperature is at (55 ± 0.5 DEG C), after record mice licks to it after putting into hot plate box Foot required time, within the 2nd day, survey again 1 time, using the meansigma methodss of continuous two days as be administered before Basic Pain Threshold value. After medication in 3rd day 30,60,90,120min measure pain threshold respectively by above-mentioned Basic Pain Threshold pH-value determination pH method.
1.3 Testing index
Go out first in hot-plate instrument when 30min, 60min, 90min, 120min after the administration of observed and recorded mice Now add the time of rear foot phenomenon.
2. glacial acetic acid is caused the impact of mouse web portion writhing pain reaction
2.1 animal packets
Female mice 50 being only randomly divided into 5 groups, often group 10, respectively model group, present invention height are (about 0.12g/ml), (about 0.06g/ml), low (about 0.03g/ml) dosage group, positive drug control group in (spasmolysis and analgesia tincture, 0.12g/ml).
2.2 experimental technique
Mice adaptability is fed two days later, and model group gavages administration with normal saline 2ml/kg；Spasmolysis and analgesia tincture Group gavages administration by 2ml/kg, one day 3 times, continuous use 2 days；High dose of the present invention, middle dosage, Low dose group all gavages administration by 2ml/kg, one day 3 times, continuous use 2 days.After 3rd day medication 1h, The glacial acetic acid 0.2ml of every mouse peritoneal injection 0.8%, respectively mice in record 10min Yu 20min Writhing number of times and each group mouse writhing suppression ratio.
Inhibitory rate: (model group writhing number of times-administration group writhing number of times)/model group writhing number of times × 100%
2.3 Testing index
Observed and recorded respectively organize mice occur after injection glacial acetic acid time (incubation period) of writhing response first with The writhing number of times occurred in 10min, 20min.
3. xylol causes mice auricle swelling and the impact of capillary permeability variation model
3.1 animal packets
Female mice 50 being only randomly divided into 5 groups, often group 10, respectively model group, present invention height are (about 0.12g/ml), (about 0.06g/ml), low (about 0.03g/ml) dosage group, positive drug control group in (spasmolysis and analgesia tincture, 0.12g/ml).
3.2 experimental technique
Mice adaptability is fed two days later, and model group gavages administration with normal saline 2ml/kg；Spasmolysis and analgesia Tincture group gavages administration by 2ml/kg, one day 3 times, continuous use 2 days；High dose of the present invention, middle dosage, Low dose group all gavages administration by 2ml/kg, one day 3 times, continuous use 2 days.It was administered same in the 3rd day Time in mouse tail vein injection 1% azovan blue 0.2ml.After last is administered 1h, each group mouse right ear two sides Drip 10 μ l caused by dimethylbenzene xylene scorching, put to death mice after 30min, with 9mm card punch in the same position of left and right ear Lay circular auricle.Weigh left and right auricle weight record.Shred auris dextra sheet to put into and fill 4ml 35% the third In the EP pipe of ketone solution.Water-bath 38 DEG C takes out leachate after soaking 48h, is centrifuged 10min with 1500r/min. Take supernatant at 590nm wavelength, survey absorbance OD value.
Swelling=auris dextra sheet weight-left auricle weight
Ear swelling suppression ratio: (model group swelling average-administration group swelling average)/model group swelling average × 100%
3.3 Testing index
Mice left and right auricle weight, auris dextra sheet leachate OD value.
4. the impact on rat hindleg acute soft tissue injury
4.1 animal packets
Female mice 50 being only randomly divided into 5 groups, often group 10, respectively model group, present invention height are (about 0.12g/ml), (about 0.06g/ml), low (about 0.03g/ml) dosage group, positive drug control group in (spasmolysis and analgesia tincture, 0.12g/ml).
4.2 experimental technique
24h before experiment, loses hair or feathers with sodium sulfide solution huckle left back to rat, after depilation 24h, and etherization Rat, and cause acute soft tissue injury with beating device leg outer side left back to rat, regards subcutaneous hemorrhage as success, It is modeling success that several minutes has touched obvious tumefaction sense.Model group gavages administration with normal saline 2ml/kg； Spasmolysis and analgesia tincture group gavages administration by 2ml/kg, one day 3 times；High dose of the present invention, middle dosage, low dose Amount group all gavages administration by 2ml/kg, one day 3 times, successive administration 6 days.Rat is carried out active state Scoring, outward appearance is marked.
4.3 Testing index
5. Data Processing in Experiment
Experimental data all withRepresent, use SPSS13.0 statistical software to be analyzed.Use single factor test Variance analysis (One-Way ANOVA) carries out significance,statistical analysis.Group difference significance uses single LSD (Least-significant difference) method in analysis of variance carries out multiple comparisons inspection Testing, P ＜ 0.05 is for there being significant difference.
6. the present invention impact on mice vola pain
Spasmolysis and analgesia tincture group demonstrates stronger analgesic activity after being administered 1h, but acts on when 2h and having declined. The present invention high, medium and low dosage group is being administered after 1h effect substantially, and to after being administered during 2h effect lasts strong Strong, when being administered 1h, analgesic activity is weaker than spasmolysis and analgesia tincture group, and after being administered 1.5h, analgesic activity is better than spasmolytic Analgesia tincture group.The present invention high, medium and low dosage group strengthens along with dosage increases analgesic activity, and high, in, Low dosage is respectively provided with stronger analgesic activity.The results are shown in Table 1:
Table 1: each comparison organizing hot plate method in mice pain experiments pain threshold
Compare before being administered, * P ＜ 0.05, * * P ＜ 0.01, * * * P ＜ 0.001；Compare with negative group,▲P ＜ 0.05,▲▲P ＜ 0.01,▲▲▲P ＜ 0.001； Compare with spasmolysis and analgesia tincture group,#P ＜ 0.05,##P ＜ 0.01；N=10
7. the present invention effect to mouse writhing pain experiments
Spasmolysis and analgesia tincture group and present invention dosage group high, middle all show stronger analgesic activity.Three dosage Being proportionate with its analgesic activity, high dose group of the present invention analgesia intensity is similar with spasmolysis and analgesia tincture group, middle dose Amount group analgesia intensity is weak compared with spasmolysis and analgesia tincture, and low dose group is without obvious analgesic activity.In preclinical comparison, solve Convulsion analgesia tincture has extremely significantly difference with negative group, and other each group differences are inconspicuous.It is shown in Table 2.
The comparison of mouse writhing number of times respectively organized by table 2
Compare with model group, * P ＜ 0.05, * * P ＜ 0.01, * * * P ＜ 0.001；Compare with spasmolysis and analgesia tincture group,▲P ＜ 0.05,▲▲P ＜ 0.01,▲▲▲P ＜ 0.001； N=10
The impact of xylol induced mice auricle edema the most of the present invention
The mice auricle swelling that each medication group dimethylbenzene causes all substantially is suppressed.Compare with model group, P ＜ 0.05, P ＜ 0.001.High dose group effect the most of the present invention is the strongest, and inhibitory rate of intumesce is 57.32%, Higher than spasmolysis and analgesia tincture group (44.62%)；Middle dosage group suppression ratio is 37.92%；Low dose group suppression ratio It is 15.03%.Show that the present invention increases antiinflammatory action with dosage and strengthens.It is shown in Table 3.
The comparison of auricle edema caused by mice dimethylbenzene respectively organized by table 3
Group Size of animal n Swelling (g) Suppression ratio
Negative group 10 0.0045±0.0007 \
Spasmolysis and analgesia tincture 10 0.0024±0.0006* * 44.62
High dose of the present invention 10 0.0021±0.0001* * ▲ ▲ 57.32
Dosage in the present invention 10 0.0028±0.0003* * ▲ 37.92
Low dosage of the present invention 10 0.0041±0.0004* ▲ ▲ ▲ 15.03
Compare with model group, * P ＜ 0.05, * * P ＜ 0.01, * * * P ＜ 0.001；Compare with spasmolysis and analgesia tincture group,▲P ＜ 0.05,▲▲P ＜ 0.01,▲▲▲P ＜ 0.001； N=10
The impact of xylol induced mice inflammation auricle capillary permeability the most of the present invention
The absorbance that each medication group is oozed out with model group Mice Auricle Evans blue dyestuff compares, and difference all has There is extremely notable meaning (P ＜ 0.001).The blood capillary that inflammation caused by each medication group xylol causes leads to Property increases and dyestuff oozes out and is respectively provided with the strongest inhibitory action thoroughly, and senior middle school of the present invention low dose group is right with the positive Approximate according to medicine spasmolysis and analgesia tincture activity, be respectively provided with stronger antiinflammatory action.It is shown in Table 4:
Table 4 is respectively organized the absorbance that Mice Auricle dyestuff oozes out and is compared
Group Size of animal n A value
Negative group 10 0.0103±0.0015
Spasmolysis and analgesia tincture 10 0.0052±0.0018* *
High dose of the present invention 10 0.0042±0.0022* *
Dosage in the present invention 10 0.0038±0.001* *
Low dosage of the present invention 10 0.0053±0.0015* *
Compare with model group, * P ＜ 0.05, * * P ＜ 0.01, * * * P ＜ 0.001；N=10
10, safety analysis and evaluation
Taking mice 26, male and female half and half, body weight 20-23g, fasting (can't help water) 12h before experiment, every Mus is pressed The maximum volume (0.5ml/10g) that is administered gavages, maximum can the concentrated solution of the present invention of gavage concentration (0.8g/ml), And within Yu Yi continuous 3 times, every minor tick 8h, Continuous Observation 7 days, have no that animal occurs death, mice Seeing that animal activity reduces after first gavage, in calm shape, after general 3-4h, activity gradually recovers, the 7th day mice Put to death after weighing, dissect, do not have seen from naked eyes the exception having obvious liver, the heart, spleen, lung, kidney.Its every day Cumulant is well beyond quantity, it is believed that clinical practice totally nontoxic.
Sum up: the present invention by pharmacodynamics test data show described in Chinese medicine composition there is analgesia, antiinflammatory Effect, the capillary permeability that inflammation caused by each medication group xylol is caused increase and dyestuff ooze out Being respectively provided with the strongest inhibitory action, above-mentioned pharmacodynamic result cures mainly with the function of the present invention and substantially matches, for Clinical practice provides pharmacology's foundation further.
Although, used general explanation, detailed description of the invention and test, the present invention made in detail Most description, but on the basis of the present invention, it can be made some amendments or improve, this is to this area skill It is apparent from for art personnel.Therefore, these done without departing from theon the basis of the spirit of the present invention are repaiied Change or improve, belonging to the scope of protection of present invention.

Claims (10)

1. the Chinese medicine composition treating periodontitis, it is characterised in that this Chinese medicine composition is by following heavy The Chinese medicine of amount part is made: Herba Asari 5-15 part, Flos Lonicerae 10-30 part, Fructus Gardeniae 10-30 part, Rhizoma Anemarrhenae 10-30 Part, Rhizoma Coptidis 5-15 part, Retinervus Luffae Fructus 5-15 part, Cortex Moutan 5-20 part, Herba Menthae 10-30 part, Gypsum Fibrosum 10-30 Part, Radix Saposhnikoviae 10-30 part, Radix Glycyrrhizae 5-20 part, Rhizoma Ligustici 10-30 part, Lignum Santali Albi 10-45 part, Pheretima 10-28 Part, Pericarpium Citri Reticulatae Viride 10-30 part, Cortex Meliae 10-30 part, Semen Lepidii (Semen Descurainiae) 10-40 part, Fructus Rubi 20-50 part.
Chinese medicine composition the most according to claim 1, it is characterised in that this Chinese medicine composition by with The Chinese medicine of lower weight portion is made: Herba Asari 7-13 part, Flos Lonicerae 12-25 part, Fructus Gardeniae 12-25 part, the Rhizoma Anemarrhenae 12-28 part, Rhizoma Coptidis 7-13 part, Retinervus Luffae Fructus 7-13 part, Cortex Moutan 7-18 part, Herba Menthae 12-28 part, Gypsum Fibrosum 12-28 part, Radix Saposhnikoviae 12-28 part, Radix Glycyrrhizae 7-18 part, Rhizoma Ligustici 12-28 part, Lignum Santali Albi 15-40 part, Pheretima 12-26 part, Pericarpium Citri Reticulatae Viride 12-28 part, Cortex Meliae 12-28 part, Semen Lepidii (Semen Descurainiae) 15-35 part, Fructus Rubi 25-45 part.
Chinese medicine composition the most according to claim 2, it is characterised in that this Chinese medicine composition by with The Chinese medicine of lower weight portion is made: Herba Asari 9-11 part, Flos Lonicerae 15-22 part, Fructus Gardeniae 15-22 part, the Rhizoma Anemarrhenae 15-22 part, Rhizoma Coptidis 9-11 part, Retinervus Luffae Fructus 9-11 part, Cortex Moutan 9-16 part, Herba Menthae 15-25 part, Gypsum Fibrosum 15-25 part, Radix Saposhnikoviae 15-25 part, Radix Glycyrrhizae 9-15 part, Rhizoma Ligustici 15-25 part, Lignum Santali Albi 20-35 part, Pheretima 15-24 part, Pericarpium Citri Reticulatae Viride 14-26 part, Cortex Meliae 14-26 part, Semen Lepidii (Semen Descurainiae) 18-32 part, Fructus Rubi 28-42 part.
Chinese medicine composition the most according to claim 3, it is characterised in that this Chinese medicine composition by with The Chinese medicine of lower weight portion is made: Herba Asari 10 parts, Flos Lonicerae 18 parts, Fructus Gardeniae 18 parts, the Rhizoma Anemarrhenae 18 parts, Huang Even 10 parts, Retinervus Luffae Fructus 10 parts, Cortex Moutan 13 parts, Herba Menthae 20 parts, 20 parts of Gypsum Fibrosum, Radix Saposhnikoviae 20 parts, 12 parts of Radix Glycyrrhizae, Rhizoma Ligustici 20 parts, 25 parts of Lignum Santali Albi, Pheretima 20 parts, 20 parts of Pericarpium Citri Reticulatae Viride, Cortex Meliae 20 parts, Semen Lepidii (Semen Descurainiae) 25 parts, Fructus Rubi 35 parts.
5. according to the Chinese medicine composition described in any one of claim 1-4, it is characterised in that this Chinese drug-treated group Compound is possibly together with pharmaceutically acceptable carrier or diluent.
Chinese medicine composition the most according to claim 5, it is characterised in that described Chinese medicine composition is Solid preparation or liquid preparation, described solid preparation is tablet, capsule, granule or pill；Described liquid Body preparation is oral liquid.
7. prepare a preparation method for Chinese medicine composition described in any one of claim 1-4, its feature Being, the method comprises the following steps: Herba Asari, Flos Lonicerae, Fructus Gardeniae, the Rhizoma Anemarrhenae, Rhizoma Coptidis, Retinervus Luffae Fructus, male Cortex Moutan, Herba Menthae, Gypsum Fibrosum, Radix Saposhnikoviae, Radix Glycyrrhizae, Rhizoma Ligustici, Lignum Santali Albi, Pheretima, Pericarpium Citri Reticulatae Viride, Cortex Meliae, Semen Lepidii (Semen Descurainiae), Fructus Rubi pulverizes and sieves, and mixs homogeneously with pharmaceutically acceptable carrier or diluent, is prepared as preparation.
8. prepare a preparation method for Chinese medicine composition described in any one of claim 1-4, its feature Being, the method comprises the following steps:
1) Chinese medicine of weight portion is weighed respectively, standby；
2) Retinervus Luffae Fructus, Cortex Moutan are added 2-5 times amount water soaking 12-24 hour, filter, filtrate concentrate drying, It is ground into fine powder, standby；Filtering residue adds ethanol 2-4 times amount heating and refluxing extraction 2-4 time of 60-90%, each 1-3 Hour, filter, filtrate recycling ethanol, dry, pulverize into fine powder, standby.
3) by Herba Asari, Flos Lonicerae, Fructus Gardeniae, the Rhizoma Anemarrhenae, Rhizoma Coptidis, Herba Menthae, Gypsum Fibrosum, Radix Saposhnikoviae, Radix Glycyrrhizae, ligusticumic Basis, Lignum Santali Albi, Pheretima, Pericarpium Citri Reticulatae Viride, Cortex Meliae, Semen Lepidii (Semen Descurainiae), Fructus Rubi add water 3-5 times amount, decoct 3-5 time, 1-3 hour every time, collecting decoction, filter, filtrate concentrates, and dry, pulverize into fine powder, standby；
4) by step 2) 3) fine powder mix homogeneously, add pharmaceutically acceptable carrier or diluent system Dosage form needed for one-tenth.
The preparation method of Chinese medicine composition the most according to claim 8, it is characterised in that the method Comprise the following steps:
1) Chinese medicine of weight portion is weighed respectively, standby；
2) Retinervus Luffae Fructus, Cortex Moutan are added 3 times amount water soaking 18 hours, filter, filtrate concentrate drying, pulverize Become fine powder, standby；The ethanol 3 times amount heating and refluxing extraction that filtering residue adds 75% 3 times, each 2 hours, filters, Filtrate recycling ethanol, dry, pulverize into fine powder, standby.
3) by Herba Asari, Flos Lonicerae, Fructus Gardeniae, the Rhizoma Anemarrhenae, Rhizoma Coptidis, Herba Menthae, Gypsum Fibrosum, Radix Saposhnikoviae, Radix Glycyrrhizae, ligusticumic Basis, Lignum Santali Albi, Pheretima, Pericarpium Citri Reticulatae Viride, Cortex Meliae, Semen Lepidii (Semen Descurainiae), Fructus Rubi add water 4 times amount, decoct 4 times, every time 2 hours, collecting decoction, filter, filtrate concentrates, and dry, pulverize into fine powder, standby；
4) by step 2) 3) fine powder mix homogeneously, add pharmaceutically acceptable carrier or diluent system Dosage form needed for one-tenth.
10. the Chinese medicine composition described in any one of claim 1-4 steams caused tooth in preparation treatment stomach-fire Gum pain, gum meat atrophy, root of the tooth a surname's dew, odontoseisis, the application in the medicine of frequent oozing of blood pyorrhea.
CN201610131459.4A 2016-03-01 2016-03-01 Traditional Chinese medicine composition for treating periodontitis and preparation method of traditional Chinese medicine composition Pending CN105796842A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610131459.4A CN105796842A (en) 2016-03-01 2016-03-01 Traditional Chinese medicine composition for treating periodontitis and preparation method of traditional Chinese medicine composition

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610131459.4A CN105796842A (en) 2016-03-01 2016-03-01 Traditional Chinese medicine composition for treating periodontitis and preparation method of traditional Chinese medicine composition

Publications (1)

Publication Number Publication Date
CN105796842A true CN105796842A (en) 2016-07-27

Family

ID=56467860

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610131459.4A Pending CN105796842A (en) 2016-03-01 2016-03-01 Traditional Chinese medicine composition for treating periodontitis and preparation method of traditional Chinese medicine composition

Country Status (1)

Country Link
CN (1) CN105796842A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106236830A (en) * 2016-08-30 2016-12-21 罗嘉辉 A kind of Chinese medicine treating periodontitis
CN107362260A (en) * 2017-08-04 2017-11-21 上海中华药业南通有限公司 A kind of permanent tooth Chinese medicine preparation

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1654056A (en) * 2004-02-10 2005-08-17 湖北丽益医药科技有限公司 Chinese medicine composition for peridentitis and preparing method thereof
CN102114084A (en) * 2011-02-21 2011-07-06 武文周 Medicine for treating periodontitis
CN102327513A (en) * 2011-09-22 2012-01-25 郭心仪 Traditional Chinese medicine for treating periodontitis
CN104161806A (en) * 2014-08-19 2014-11-26 贵州同济堂制药有限公司 Traditional Chinese medicine composition for treating toothache and preparation method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1654056A (en) * 2004-02-10 2005-08-17 湖北丽益医药科技有限公司 Chinese medicine composition for peridentitis and preparing method thereof
CN102114084A (en) * 2011-02-21 2011-07-06 武文周 Medicine for treating periodontitis
CN102327513A (en) * 2011-09-22 2012-01-25 郭心仪 Traditional Chinese medicine for treating periodontitis
CN104161806A (en) * 2014-08-19 2014-11-26 贵州同济堂制药有限公司 Traditional Chinese medicine composition for treating toothache and preparation method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106236830A (en) * 2016-08-30 2016-12-21 罗嘉辉 A kind of Chinese medicine treating periodontitis
CN107362260A (en) * 2017-08-04 2017-11-21 上海中华药业南通有限公司 A kind of permanent tooth Chinese medicine preparation

Similar Documents

Publication Publication Date Title
CN1840117A (en) Dermatosis-treating medicine
CN102228599A (en) Chinese medicinal preparation for treating tumor
CN105796842A (en) Traditional Chinese medicine composition for treating periodontitis and preparation method of traditional Chinese medicine composition
CN103263531A (en) Chinese medicine composition for treating prosopalgia and preparation method thereof
CN1985921B (en) Chinese medicine composition for treating common cold and its preparing method
CN101396542A (en) Traditional Chinese medicine formulation for treating gastrosis and preparation method thereof
CN103495099B (en) Chinese medicine preparation for nursing patient with toothache and preparation method thereof
KR20160131225A (en) The herbal mixture extract as an active ingredient health supplement food for mproving gastrointestinal disorders and indigestion and the health-aid food manufactured thereby
KR20160131130A (en) The herbal mixture extract as an active ingredient therapeutic compositions for mproving gastrointestinal disorders and indigestion and the therapeutic compositions manufactured thereby
CN101461925B (en) Medicament composition for treating hepatopathy and preparation method thereof
CN101543577A (en) Traditional Chinese medicine composition for curing whelk and preparation method thereof
CN1695673A (en) Chinese medicinal preparation for treating high blood pressure and high blood fat
CN103520684B (en) Traditional Chinese medicine compound for reducing blood sugar
CN102895387A (en) Kidney-yang-warming medicine composition, and preparation thereof and preparation method thereof
CN102716419B (en) Compound oral liquid for developing intelligence and tonifying kidneys
CN102552711B (en) Traditional Chinese medicine composition for treating hypertension
CN104758592A (en) Traditional Chinese medicine capsule preparation for treating toothache due to wind-fire evil
CN103566219A (en) Traditional Chinese medicine composition for treating cold
CN103536879A (en) Pharmaceutical composition for treating diabetes mellitus and preparation method thereof
CN103239632B (en) Chinese medicine preparation for treating chronic periodontitis
CN103182025A (en) Traditional Chinese medicine composition for treating bradyarrhythmia, and application thereof
CN106177075A (en) The cold compress bag for the treatment of allergic skin and preparation method thereof
CN102908508B (en) Medicinal composition for treating seborrheic alopecia and preparation method thereof
CN105726713B (en) Traditional Chinese medicine composition and preparation method and application thereof
CN108606996A (en) It is a kind of that there is the pharmaceutical composition for improving immune function

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20160727

WD01 Invention patent application deemed withdrawn after publication