CN105796693A - Medicine composition for preventing diphtheritic fowl pox and preparation method and application thereof - Google Patents
Medicine composition for preventing diphtheritic fowl pox and preparation method and application thereof Download PDFInfo
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
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- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract
The invention provides a medicine composition for preventing diphtheritic fowl pox.The medicine composition is prepared from, by weight, 6-8 parts of scutellariae radix veta, 6-8 parts of radix sophorae tonkinensis, 6-8 parts of borax, 4-6 parts of puffball, 4-6 parts of cortex moutan, 3-5 parts of berberis poiretii schneid, 3-5 parts of sanguisorba officinalis, 4-6 parts of VB2 and 2-4 parts of licorice root.The invention further provides a preparation method and application of the medicine composition.A formulation is selected according to clinical characteristics, clinical symptoms and pathological manifestations of diphtheritic fowl pox, the medicine composition has the effects of clearing away heat and toxin, eliminating inflammation and stopping bleeding, eliminating swelling and promoting tissue regeneration, promoting wound healing and preventing secondary infection, and a good treatment and repair function is achieved on chicken oral cavity and throat acne marks caused by pox viruses.The medicine composition is simple in preparation method, remarkable in treatment effect and convenient to use.When used, the medicine composition is added into water and drunk by chickens.
Description
Technical field
The invention belongs to veterinary drug technical field, be specifically related to a kind of pharmaceutical composition preventing and treating Diphterin type pox and its preparation method and application.
Background technology
Fowlpox is a kind of contagious disease of the chicken caused by bird pox virus, the most often can be divided into skin-type, diphtheria type and mixed type.Betide skin, referred to as skin-type；Betide oral cavity and throat, referred to as diphtheria type；Both have concurrently, referred to as mixed type.All can fall ill regardless of age in days, size, broiler and laying hen all can infect, and in period of disease 1-2 week, chickling mortality rate is higher, up to 5%～30% not etc. (Yin Zhen etc., animal virology (second edition), Beijing: Science Press, 1997,955,959,325-329).M & M is on the rise in recent years, and the case of immuning failure happens occasionally (Chang Zengshan etc., experimental chicken group breaks out the diagnosis report that fowlpox concurrent bacterial infects, Chinese Poultry industry guide, 2003 (24): 27).For the treatment of fowlpox, there is no specific medicament at present, generally use symptomatic therapy, utilize chemicals and antibiotic to alleviate the symptom of disease chicken and to prevent secondary bacterial disease.But chemical medicine and antibiotic is a large amount of and commonly used, does not meets " healthy aquaculture, green cultivation " concept.And the Ministry of Agriculture has prohibitted the use of moroxydine hydrochloride, virazole etc. for preventing and treating animal viral disease.Chinese medicine preparation is substantially based on oral powder at present, and direct spice is fed, and owing to the digestive tract of chicken own is shorter and smaller, drug powder time of staying in digestive tract is short, and active component dissolution is insufficient, affects its curative effect, therefore effect is the most not ideal；Many clinically and chemicals compatibility is applied.It addition, suffer from the sick chicken of Diphterin type pox due to the ill wound of throat, therefore dysphagia, application powder treatment is not most suitable, and at this moment liquid preparation is exactly more satisfactory preparation.
Summary of the invention
In order to solve problems of the prior art, the invention provides a kind of pharmaceutical composition for preventing and treating Diphterin type pox, the present invention also provides for its preparation method and application.This pharmaceutical composition is a kind of liquid preparation, during use, is added to the water, allows chicken drink.
First purpose of the present invention is to provide a kind of pharmaceutical composition preventing and treating Diphterin type pox, and described pharmaceutical composition is made up of the crude drug of following weight portion: Radix Scutellariae 6-8 part, Radix Sophorae Tonkinensis 6-8 part, Borax 6-8 part, Lasiosphaera Seu Calvatia 4-6 part, Cortex Moutan 4-6 part, Radix Berberidis 3-5 part, Radix Sanguisorbae 3-5 part, VB24-6 part, Radix Glycyrrhizae 2-4 part.
As preferably, described pharmaceutical composition is made up of the crude drug of following weight portion: Radix Scutellariae 7 parts, Radix Sophorae Tonkinensis 7 parts, Borax 7 parts, Lasiosphaera Seu Calvatia 5 parts, Cortex Moutan 5 parts, Radix Berberidis 4 parts, Radix Sanguisorbae 4 parts, VB25 parts, 3 parts of Radix Glycyrrhizae.
Second object of the present invention is to provide the preparation method of aforementioned pharmaceutical compositions, weigh Radix Scutellariae 6-8 part, Radix Sophorae Tonkinensis 6-8 part, Lasiosphaera Seu Calvatia 4-6 part, Cortex Moutan 4-6 part, Radix Berberidis 3-5 part, Radix Sanguisorbae 3-5 part, Radix Glycyrrhizae 2-4 part by weight, add the soak by water 2 hours of 9-11 times of weight, add 7-9 times amount soak by water again 2 hours, collecting decoction, filtration, it is concentrated into about 1-1.2g/ml, adds Borax 6-8 part, VB24-6 part, stirs, mixes, to obtain final product.
Third object of the present invention is to provide pharmaceutical composition application in the medicine of preparation preventing and treating Diphterin type pox.
Fourth object of the present invention is to provide a kind of medicine, and its effective ingredient is the pharmaceutical composition described in claim 1 or 2.
As preferably, described medicine also includes medically acceptable adjuvant.
As preferably, the dosage form of described medicine is oral liquid.
As preferably, the consumption of described medicine is each 1ml/kg body weight, every day 2 times, is used in conjunction 5-7 days.
Chicken Diphterin type pox is oral cavity and the throat membranes that bird pox virus mainly encroaches on chicken, and at oral cavity and bottleneck throat mucosa generation varioliform exanthema.The yellow spotting that initial stage is rounded, gradually forms one layer of yellow-white pseudomembrane, covers on mucosa.Along with disease, pseudomembrane constantly expands and thickens, and oral cavity and bottleneck throat are blocked, and sick chicken swallows and breathing is affected, dyspnea, severe patient death by suffocation.
Radix Scutellariae clearing away lung-heat in the present invention, has antiinflammatory, anti-secondary infection effect；Radix Sophorae Tonkinensis heat-clearing and toxic substances removing, detumescence sore-throat relieving, expelling phlegm for arresting cough effect；Lasiosphaera Seu Calvatia has sore hemostasis, secondary infection effect antibacterial, anti-；Cortex Moutan can be good at antiinflammatory, antibacterial, enhancing immunization；Radix Berberidis all has good antibacterial action to staphylococcus aureus, Class B streptococcus and escherichia coli；Borax has anticorrosion and the effect of protection mucosa, because it is alkalescence, can make mucosa de-sludging；VB2Participate in the growth metabolism of cell, be the necessary nutrient of when injected organism tissue metabolism and reparation；Radix Sanguisorbae cooling blood for hemostasis, antibacterial, secondary infection can be prevented and treated, reduce wound surface and ooze out, wound healing；Radix Glycyrrhizae and middle emergency, coordinating the actions of various ingredients in a prescription.All medicines share, the hemostasis of heat-clearing and toxic substances removing, antiinflammatory, detumescence and promoting granulation, wound healing, prevention secondary infection, have well treatment and repair to the chicken oral cavity caused because of poxvirus and bottleneck throat pox spots.
The pharmaceutical composition preparation method of the present invention is simple, evident in efficacy, easy to use, is added to the water by this pharmaceutical composition, allows chicken drink.
Detailed description of the invention
Below example facilitates a better understanding of the present invention, but does not limit the present invention.Experimental technique in following embodiment, if no special instructions, is conventional method.Test material used in following embodiment, if no special instructions, is commercially available.
A kind of pharmaceutical composition for preventing and treating Diphterin type pox, is prepared from by the crude drug of following weight portion:
Radix Scutellariae 6-8 part, Radix Sophorae Tonkinensis 6-8 part, Borax 6-8 part, Lasiosphaera Seu Calvatia 4-6 part, Cortex Moutan 4-6 part, Radix Berberidis 3-5 part, Radix Sanguisorbae 3-5 part, VB24-6 part, Radix Glycyrrhizae 2-4 part.
The preparation method of aforementioned pharmaceutical compositions is:
Weigh Radix Scutellariae 6-8 part, Radix Sophorae Tonkinensis 6-8 part, Lasiosphaera Seu Calvatia 4-6 part, Cortex Moutan 4-6 part, Radix Berberidis 3-5 part, Radix Sanguisorbae 3-5 part, Radix Glycyrrhizae 2-4 part by weight, add the soak by water 2 hours of 10 times of weight, add 8 times amount soak by water again 2 hours, collecting decoction, filtration, it is concentrated into about 1g/ml, adds Borax 6-8 part, VB24-6 part, stirs, mixes, to obtain final product.
According to the Ministry of Agriculture " novel chiral synthon general toxicity test specification ", this medicine is carried out acute toxicity test, its LD of result50> 34560mg/kg, can be assessed as actual nontoxic.
When this pharmaceutical composition is prepared as medicine, it is also possible to add medically acceptable adjuvant.
Clinical trial:
Make an addition to, in drinking-water, allow chicken freely drink water by 1ml/kg body weight by the pharmaceutical composition of the present invention.
Certain chicken house laying hen, do not do fowlpox immunity, initial discovery minority chicken lethargy, search for food and minimizing of drinking water, time have and dehisce to breathe, laying rate is declined slightly, indivedual chickens stream nose liquid, eye closing or eye flowing water sample or mucoid liquid, eyelid swelled, chicken has fragmentary death, uses Multiple Classes of Antibiotics DeGrain, then goes to a doctor.
Checking sick chicken, show as diet and be intended to reduce, spirit is tired, and flow out viscous liquid for eye and nostril, or eyelid swelled, or conjunctiva is full of purulence or fibrinous exudate；Laying rate is dropped to 76% by 87% before ill；Cuing open check weighing disease and dead chicken, in oral cavity, throat etc. mucosa finds varioliform exanthema, have for circular yellow spotting, have is covered on mucosa for a thin layer yellow-white pseudomembrane, and sick chicken swallows and breathes in impact.Skin has no pox spots.Make the suspension of 1:5 with chicken oropharynx pseudomembrane of dying of illness, take 5 healthy chickens, suspension is rubbed in the cockscomb scratched；After 5 d, all there is typical varioliform exanthema symptom in 5 inoculation chickens.Through Clinical anatomic and laboratory diagnosis, it is diagnosed as Diphterin type pox.
Treatment: 1856 chickens are divided into medicine group and blank group, wherein medication therapy groups 1702, blank group 154.Medicine group chicken presses 1mL/kg body weight drinking water administration, every day 2 times, is used in conjunction 7 days；Blank group is not administered.
Result: after treatment group medication, whole chicken group's disease gradually takes a turn for the better, more anosis chicken death, breathes and becomes more to lead to intestinal, and feed intake increases；After medication 5 days, cluster chicken diet is intended to normal, breathes smoothness, continues medication 2 days, and cluster chicken is fully recovered；Laying rate is gone up to 84%.And the chicken of blank group still diet is intended to lowly, symptom does not subtracts, and has again 11 death within 7 days, and laying rate drops to 72%.
Conclusion: the pharmaceutical composition of the present invention is pressed the method for 1mL/kg body weight and is administered with water way, every day 2 times, is used in conjunction 7 days, has good preventive and therapeutic effect to Diphterin type pox.
The present invention is according to characteristics of incidence, clinical symptoms and the pathological manifestations prescription of Diphterin type pox, heat-clearing and toxic substances removing, antiinflammatory hemostasis, detumescence and promoting granulation, wound healing, prevention secondary infection, have well treatment and repair to the chicken oral cavity caused because of poxvirus and bottleneck throat pox spots.
Embodiment 1
The formula of a kind of pharmaceutical composition for preventing and treating Diphterin type pox of the present invention is as follows:
Radix Scutellariae 7g, Radix Sophorae Tonkinensis 7g, Borax 7g, Lasiosphaera Seu Calvatia 5g, Cortex Moutan 5g, Radix Berberidis 4g, Radix Sanguisorbae 4g, VB25g, Radix Glycyrrhizae 3g.
The preparation method of a kind of pharmaceutical composition for preventing and treating Diphterin type pox of the present invention is as follows:
Weigh Radix Scutellariae 7g, Radix Sophorae Tonkinensis 7g, Lasiosphaera Seu Calvatia 5g, Cortex Moutan 5g, Radix Berberidis 4g, Radix Sanguisorbae 4g and Radix Glycyrrhizae 3g, add the soak by water 2 hours of 10 times of weight, then add 8 times amount soak by water 2 hours, collecting decoction, filtration, it is concentrated into about 1g/ml, adds Borax 7g, VB25g, stirs, mixes, to obtain final product.
Embodiment 2
The formula of a kind of pharmaceutical composition for preventing and treating Diphterin type pox of the present invention is as follows:
Radix Scutellariae 60g, Radix Sophorae Tonkinensis 75g, Borax 75g, Lasiosphaera Seu Calvatia 45g, Cortex Moutan 55g, Radix Berberidis 50g, Radix Sanguisorbae 50g, VB260g, Radix Glycyrrhizae 20g.
The preparation method of a kind of pharmaceutical composition for preventing and treating Diphterin type pox of the present invention is as follows:
Weigh Radix Scutellariae 60g, Radix Sophorae Tonkinensis 75g, Lasiosphaera Seu Calvatia 45g, Cortex Moutan 55g, Radix Berberidis 50g, Radix Sanguisorbae 50g and Radix Glycyrrhizae 20g, add the soak by water 2 hours of 9 times of weight, then add 9 times amount soak by water 2 hours, collecting decoction, filtration, it is concentrated into about 1.1g/ml, adds Borax 75g, VB260g, stirs, mixes, to obtain final product.
Embodiment 3
The formula of a kind of pharmaceutical composition for preventing and treating Diphterin type pox of the present invention is as follows:
Radix Scutellariae 80g, Radix Sophorae Tonkinensis 60g, Borax 60g, Lasiosphaera Seu Calvatia 60g, Cortex Moutan 40g, Radix Berberidis 30g, Radix Sanguisorbae 30g, VB260g, Radix Glycyrrhizae 40g.
The preparation method of a kind of pharmaceutical composition for preventing and treating Diphterin type pox of the present invention is as follows:
Weigh Radix Scutellariae 80g, Radix Sophorae Tonkinensis 60g, Lasiosphaera Seu Calvatia 60g, Cortex Moutan 40g, Radix Berberidis 30g, Radix Sanguisorbae 30g and Radix Glycyrrhizae 40g, add the soak by water 2 hours of 11 times of weight, then add 8 times amount soak by water 2 hours, collecting decoction, filtration, it is concentrated into about 1.2g/ml, adds Borax 60g, VB260g, stirs, mixes, to obtain final product.
Embodiment 4
The formula of a kind of pharmaceutical composition for preventing and treating Diphterin type pox of the present invention is as follows:
Radix Scutellariae 70g, Radix Sophorae Tonkinensis 80g, Borax 80g, Lasiosphaera Seu Calvatia 40g, Cortex Moutan 60g, Radix Berberidis 35g, Radix Sanguisorbae 40g, VB240g, Radix Glycyrrhizae 30g.
The preparation method of a kind of pharmaceutical composition for preventing and treating Diphterin type pox of the present invention is as follows:
Weigh Radix Scutellariae 80g, Radix Sophorae Tonkinensis 60g, Lasiosphaera Seu Calvatia 60g, Cortex Moutan 40g, Radix Berberidis 30g, Radix Sanguisorbae 30g and Radix Glycyrrhizae 40g, add the soak by water 2 hours of 10 times of weight, then add 7 times amount soak by water 2 hours, collecting decoction, filtration, it is concentrated into about 1.1g/ml, adds Borax 60g, VB260g, stirs, mixes, to obtain final product.
Embodiment 5
The formula of a kind of pharmaceutical composition for preventing and treating Diphterin type pox of the present invention is as follows:
Radix Scutellariae 75g, Radix Sophorae Tonkinensis 65g, Borax 75g, Lasiosphaera Seu Calvatia 55g, Cortex Moutan 45g, Radix Berberidis 30g, Radix Sanguisorbae 45g, VB250g, Radix Glycyrrhizae 35g.
The preparation method of a kind of pharmaceutical composition for preventing and treating Diphterin type pox of the present invention is as follows:
Weigh Radix Scutellariae 75g, Radix Sophorae Tonkinensis 65g, Lasiosphaera Seu Calvatia 55g, Cortex Moutan 45g, Radix Berberidis 30g, Radix Sanguisorbae 45g and Radix Glycyrrhizae 35g, add the soak by water 2 hours of 11 times of weight, then add 9 times amount soak by water 2 hours, collecting decoction, filtration, it is concentrated into about 1g/ml, adds Borax 75g, VB250g, stirs, mixes, to obtain final product.
Embodiment 6
The formula of a kind of pharmaceutical composition for preventing and treating Diphterin type pox of the present invention is as follows:
Radix Scutellariae 65g, Radix Sophorae Tonkinensis 75g, Borax 70g, Lasiosphaera Seu Calvatia 50g, Cortex Moutan 55g, Radix Berberidis 35g, Radix Sanguisorbae 35g, VB255g, Radix Glycyrrhizae 25g.
The preparation method of a kind of pharmaceutical composition for preventing and treating Diphterin type pox of the present invention is as follows:
Weigh Radix Scutellariae 65g, Radix Sophorae Tonkinensis 75g, Lasiosphaera Seu Calvatia 50g, Cortex Moutan 55g, Radix Berberidis 35g, Radix Sanguisorbae 35g and Radix Glycyrrhizae 25g, add the soak by water 2 hours of 9 times of weight, then add 8 times amount soak by water 2 hours, collecting decoction, filtration, it is concentrated into about 1.2g/ml, adds Borax 70g, VB255g, stirs, mixes, to obtain final product.
Last it is noted that the foregoing is only the preferred embodiments of the present invention, it is not limited to the present invention, although the present invention being described in detail with reference to previous embodiment, for a person skilled in the art, technical scheme described in foregoing embodiments still can be modified by it, or wherein portion of techniques feature is carried out equivalent.All within the spirit and principles in the present invention, any modification, equivalent substitution and improvement etc. made, should be included within the scope of the present invention.
Claims (8)
1. the pharmaceutical composition preventing and treating Diphterin type pox, it is characterised in that: described pharmaceutical composition is made up of the crude drug of following weight portion: Radix Scutellariae 6-8 part, Radix Sophorae Tonkinensis 6-8 part, Borax 6-8 part, Lasiosphaera Seu Calvatia 4-6 part, Cortex Moutan 4-6 part, Radix Berberidis 3-5 part, Radix Sanguisorbae 3-5 part, VB2
4-6 part, Radix Glycyrrhizae 2-4 part.
Pharmaceutical composition the most according to claim 1, it is characterised in that: described pharmaceutical composition is made up of the crude drug of following weight portion: Radix Scutellariae 7 parts, Radix Sophorae Tonkinensis 7 parts, Borax 7 parts, Lasiosphaera Seu Calvatia 5 parts, Cortex Moutan 5 parts, Radix Berberidis 4 parts, Radix Sanguisorbae 4 parts, VB25 parts, 3 parts of Radix Glycyrrhizae.
3. the preparation method of the pharmaceutical composition described in claim 1 or 2, it is characterized in that: weigh Radix Scutellariae 6-8 part, Radix Sophorae Tonkinensis 6-8 part, Lasiosphaera Seu Calvatia 4-6 part, Cortex Moutan 4-6 part, Radix Berberidis 3-5 part, Radix Sanguisorbae 3-5 part, Radix Glycyrrhizae 2-4 part by weight, add the soak by water 2 hours of 9-11 times of weight, add 7-9 times amount soak by water again 2 hours, collecting decoction, filtration, it is concentrated into about 1-1.2g/ml, adds Borax 6-8 part, VB24-6 part, stirs, mixes, to obtain final product.
4. the application in the medicine of preparation preventing and treating Diphterin type pox of the pharmaceutical composition described in claim 1 or 2.
5. a medicine, its effective ingredient is the pharmaceutical composition described in claim 1 or 2.
Medicine the most according to claim 5, it is characterised in that: described medicine also includes medically acceptable adjuvant.
7. according to the medicine described in claim 5 or 6, it is characterised in that: the dosage form of described medicine is oral liquid.
8. according to the medicine described in claim 5 or 6, it is characterised in that: the consumption of described medicine is each 1ml/kg body weight, every day 2 times, is used in conjunction 5-7 days.
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