CN105794793A - Sterilization composition containing fluxapyroxad - Google Patents
Sterilization composition containing fluxapyroxad Download PDFInfo
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- CN105794793A CN105794793A CN201610220585.7A CN201610220585A CN105794793A CN 105794793 A CN105794793 A CN 105794793A CN 201610220585 A CN201610220585 A CN 201610220585A CN 105794793 A CN105794793 A CN 105794793A
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- Prior art keywords
- fluxapyroxad
- active component
- disease
- agent
- probenazole
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- 239000005788 Fluxapyroxad Substances 0.000 title claims abstract description 76
- SXSGXWCSHSVPGB-UHFFFAOYSA-N fluxapyroxad Chemical compound FC(F)C1=NN(C)C=C1C(=O)NC1=CC=CC=C1C1=CC(F)=C(F)C(F)=C1 SXSGXWCSHSVPGB-UHFFFAOYSA-N 0.000 title claims abstract description 76
- 239000000203 mixture Substances 0.000 title claims abstract description 49
- 230000001954 sterilising effect Effects 0.000 title abstract 3
- 238000004659 sterilization and disinfection Methods 0.000 title abstract 3
- 201000010099 disease Diseases 0.000 claims abstract description 42
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 42
- WHHIPMZEDGBUCC-UHFFFAOYSA-N probenazole Chemical compound C1=CC=C2C(OCC=C)=NS(=O)(=O)C2=C1 WHHIPMZEDGBUCC-UHFFFAOYSA-N 0.000 claims abstract description 29
- 239000000375 suspending agent Substances 0.000 claims description 31
- 235000007164 Oryza sativa Nutrition 0.000 claims description 30
- 235000009566 rice Nutrition 0.000 claims description 29
- 230000000844 anti-bacterial effect Effects 0.000 claims description 16
- 239000003094 microcapsule Substances 0.000 claims description 14
- 239000000839 emulsion Substances 0.000 claims description 12
- 241000221785 Erysiphales Species 0.000 claims description 11
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims description 11
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- 241001530056 Athelia rolfsii Species 0.000 claims description 7
- 241000233679 Peronosporaceae Species 0.000 claims description 7
- 239000000725 suspension Substances 0.000 claims description 7
- 239000004530 micro-emulsion Substances 0.000 claims description 6
- 239000004562 water dispersible granule Substances 0.000 claims description 6
- 239000004563 wettable powder Substances 0.000 claims description 6
- 241000607479 Yersinia pestis Species 0.000 claims description 4
- 240000007594 Oryza sativa Species 0.000 claims description 2
- IUOKJNROJISWRO-UHFFFAOYSA-N N-(2-cyano-3-methylbutan-2-yl)-2-(2,4-dichlorophenoxy)propanamide Chemical compound CC(C)C(C)(C#N)NC(=O)C(C)OC1=CC=C(Cl)C=C1Cl IUOKJNROJISWRO-UHFFFAOYSA-N 0.000 abstract description 26
- UFHLMYOGRXOCSL-UHFFFAOYSA-N isoprothiolane Chemical compound CC(C)OC(=O)C(C(=O)OC(C)C)=C1SCCS1 UFHLMYOGRXOCSL-UHFFFAOYSA-N 0.000 abstract description 26
- 230000000694 effects Effects 0.000 abstract description 14
- 150000001875 compounds Chemical class 0.000 abstract description 4
- 230000000855 fungicidal effect Effects 0.000 abstract description 4
- 239000000417 fungicide Substances 0.000 abstract description 3
- 238000001228 spectrum Methods 0.000 abstract description 2
- 239000004480 active ingredient Substances 0.000 abstract 6
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 46
- 239000003814 drug Substances 0.000 description 40
- 239000002131 composite material Substances 0.000 description 37
- 241000209094 Oryza Species 0.000 description 29
- 230000003449 preventive effect Effects 0.000 description 24
- 239000000575 pesticide Substances 0.000 description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 15
- 239000013530 defoamer Substances 0.000 description 14
- 239000002270 dispersing agent Substances 0.000 description 14
- 239000012071 phase Substances 0.000 description 13
- 241000209140 Triticum Species 0.000 description 12
- 235000021307 Triticum Nutrition 0.000 description 12
- 239000008367 deionised water Substances 0.000 description 11
- 229910021641 deionized water Inorganic materials 0.000 description 11
- 239000003995 emulsifying agent Substances 0.000 description 10
- 239000002904 solvent Substances 0.000 description 10
- 239000000080 wetting agent Substances 0.000 description 10
- 230000002528 anti-freeze Effects 0.000 description 9
- 238000000034 method Methods 0.000 description 9
- 239000002562 thickening agent Substances 0.000 description 9
- 239000008187 granular material Substances 0.000 description 8
- 230000002265 prevention Effects 0.000 description 8
- 206010067482 No adverse event Diseases 0.000 description 7
- 230000010165 autogamy Effects 0.000 description 7
- 239000006071 cream Substances 0.000 description 7
- 229940079593 drug Drugs 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- 206010011732 Cyst Diseases 0.000 description 5
- 239000008346 aqueous phase Substances 0.000 description 5
- 244000052616 bacterial pathogen Species 0.000 description 5
- 208000031513 cyst Diseases 0.000 description 5
- 239000004615 ingredient Substances 0.000 description 5
- 229920002521 macromolecule Polymers 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 231100000820 toxicity test Toxicity 0.000 description 5
- 239000000945 filler Substances 0.000 description 4
- 230000005764 inhibitory process Effects 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 239000003002 pH adjusting agent Substances 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- -1 pyrazole amide Chemical class 0.000 description 4
- 239000004094 surface-active agent Substances 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 3
- 230000008485 antagonism Effects 0.000 description 3
- 238000000498 ball milling Methods 0.000 description 3
- 239000011230 binding agent Substances 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 235000013399 edible fruits Nutrition 0.000 description 3
- 238000013401 experimental design Methods 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 230000002045 lasting effect Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 230000009471 action Effects 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical group C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 2
- 230000009036 growth inhibition Effects 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001018 virulence Effects 0.000 description 2
- 244000241257 Cucumis melo Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 241001330975 Magnaporthe oryzae Species 0.000 description 1
- 102000019259 Succinate Dehydrogenase Human genes 0.000 description 1
- 108010012901 Succinate Dehydrogenase Proteins 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 238000012271 agricultural production Methods 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 239000010242 baoji Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 235000010290 biphenyl Nutrition 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 244000037666 field crops Species 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 239000002917 insecticide Substances 0.000 description 1
- 235000021374 legumes Nutrition 0.000 description 1
- 230000037356 lipid metabolism Effects 0.000 description 1
- 239000010871 livestock manure Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 230000008099 melanin synthesis Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
Abstract
The invention discloses sterilization composition containing fluxapyroxad. The sterilization composition comprises an active ingredient A and an active ingredient B, wherein the active ingredient A is selected from fluxapyroxad, the active ingredient B is selected from any one of compounds including isoprothiolane, fenoxanil and probenazole, and the weight ratio of the active ingredient A to the active ingredient B is (1:80)-(60:1). The composition has higher activity for multiple diseases of various crops, has a remarkable synergistic effect, expands the fungicide spectrum and has the characteristics of small use amount, rain wash resistance and remarkable synergism.
Description
The application is divisional application, and original application is the patent application " bactericidal composition of a kind of Fluxapyroxad-containsterilization " of Shaanxi Welch Crop Protection Co., Ltd., and the application number of original application is 2012101664956, and original application day is 2012.05.25.
Technical field
The invention belongs to technical field of pesticide, relate to the application in crop pest of the bactericidal composition of a kind of Fluxapyroxad-containsterilization.
Technical background
Fluxapyroxad (fluxapyroxad) chemical name: 3-(difluoro)-1-methyl-N-(3', 4', 5'-trifluoro [1,1'-biphenyl]-2-base)-1-H-pyrazoles-4-amide, fluxapyroxad belongs to pyrazole amide series bactericidal agent, succinate dehydrogenase inhibitors.Superior lasting effect and lasting transmission characteristic are integrated in one.
Isoprothiolane (isoprothiolane) chemical name: diisopropyl-1,3-dithiolane-a-phenyl malonic ester, molecular formula: C12H18O4S2, Isoprothiolane is systemic fungicide, and rice blast is had specially good effect.Rice plant accumulates on leaf texture after absorbing medicament, specifically focuses on cob and branch stalk, thus suppressing pathogenic bacteria intrusion, hindering pathogenic bacteria lipid metabolism, it is suppressed that pathogen growth, playing prevention and treatment.
Fenoxanil (fenoxanil) chemical name: N-(1-itrile group-1,2-dimethyl propyl)-2-(2,4-dichlorophenoxy) propionic acid amide., molecular formula: C15H18Cl2N2O2, fenoxanil is a novel systemic fungicide for preventing and treating rice blast, has novel mechanism of action, belongs to melanin biosynthesis inhibitor (MBI), preventing and treating rice blast excellent on blade face and when using under water, and holding effect is notable.
Probenazole (probenazole) chemical name: PROBENAZOLE, molecular formula: C10H9NO3S, probenazole can extensively protect and eradicate land for growing field crops effect, fruit tree, grassland, vegetable pathogenic bacteria；Slightly antimicrobial acivity in isolated test；Processing Oryza sativa L., promote Root Absorption, cover crop is infecting by Pyricularia oryzae and rice bacterial leaf spot pathogenic bacteria.
But, in the real process of agricultural production, pest control is easiest to generate the problem that the generation of pest resistance to insecticide.Different cultivars composition carries out composite, is prevent and treat the method that resistant insect is very common.Heterogeneity carries out composite, according to practical application effect, judge certain composite be potentiation, add and or antagonism.In most cases, the composite effect of pesticide is all additive effect, really have potentiation composite seldom, especially potentiation clearly, significantly high composite just less of co-toxicity coefficient.Study through inventor, it has been found that can will produce good potentiation after composite to fluxapyroxad and Isoprothiolane, fenoxanil, probenazole, and not yet open about the relevant report that fluxapyroxad and Isoprothiolane, fenoxanil, probenazole are composite.
Summary of the invention
Fluxapyroxad and Isoprothiolane, fenoxanil, probenazole single dose life-time service are likely to bring resistance to occur, degradation problem under drug effect, and the bactericidal composition that the present invention proposes contains active components A and active component B, and appropriate surfactant and carrier.
A kind of bactericidal composition of Fluxapyroxad-containsterilization, containing active components A and active component B, active components A and active component B weight ratio are 1 80～60 1, described active components A is selected from fluxapyroxad, active component B one in Isoprothiolane, fenoxanil, probenazole, active components A and active component B preferably weight ratio are 1 60～40 1；The weight ratio being more preferably fluxapyroxad and Isoprothiolane is 1 25～5 1, and the weight ratio of fluxapyroxad and fenoxanil is 1 20～10 1, and the weight ratio of fluxapyroxad and probenazole is 1 35～5 1.
The bactericidal composition of described Fluxapyroxad-containsterilization is for preventing and treating the disease of crops, and described crops include cereal crops, legume crop, oil crop, fibre crops, sugar crop, melon crop, fruits crop, dry fruit crop, hobby crop, root crop, flower crop, medicinal crop, crop, green manure pasture crop.
Described disease includes rice blast, leaf blight, bakanae disease, false smut, banded sclerotial blight, powdery mildew, rust, leaf spot, moire disease, net blotch, downy mildew, late blight, stripe disease.
In the present composition, the content of active component depends on amount of application when being used alone, and also depends on mixed ratio and the potentiation degree of a kind of compound and another kind of compound, simultaneously also relevant with target disease.In usual compositions, the weight percentage of active component is the 1%～90% of gross weight, it is advantageous to be 5%～80%.According to different preparation types, active component content scope is different.Generally, liquid preparation contains the active substance of by weight 1%～60%, it is preferred that be 5%～50%；Solid preparation contains the active substance of by weight 5%～80%, it is preferred that be 10%～80%.
The bactericidal composition of the present invention at least contains a kind of surfactant, active component dispersion in water when being beneficial to use.Surface-active contents is the 2%～30% of total formulation weight amount, and surplus is solid or liquid diluent.
Surfactant selected by the bactericidal composition of the present invention is known in those skilled in the art: can be selected from one or more in dispersant, wetting agent, thickening agent or defoamer.According to different dosage form, can also containing stabilizer known in those skilled in the art, antifreeze etc. in preparation.
The bactericidal composition of the present invention can by user before use through diluting or directly using.Its preparation can be prepared by processing method known in those skilled in the art, after mixing with liquid flux or solid carrier by active component, adds one or more in surfactant such as dispersant, stabilizer, wetting agent, binding agent, defoamer etc..
The bactericidal composition of the present invention can be processed into acceptable dosage form on any pesticide on demand, wherein preferred dosage form is wettable powder, water dispersible granules, suspending agent, suspension emulsion, microemulsion, aqueous emulsion, microcapsule suspending agent, microcapsule suspension-suspendinagent agent, it is also possible to make granule.
Compositions comprises following component and content when making wettable powder: active components A 1%～60%, active component B1%～80%, dispersant 1%～12%, wetting agent 1%～8%, filler surplus.
Compositions includes following component and content when making water dispersible granules: active components A 1%～60%, active component B1%～80%, dispersant 1%～12%, wetting agent 1%～8%, disintegrating agent 1%～10%, binding agent 0～8%, filler surplus.
Compositions includes following component and content when making suspending agent: active components A 1%～50%, active component B1%～50%, dispersant 1%～10%, wetting agent 1%～10%, defoamer 0.01%～2%, thickening agent 0～2%, antifreeze 0～8%, deionized water add to 100%.
Compositions includes following component and content when making suspension emulsion: active components A 1%～50%, active component B1%～50%, emulsifying agent 1%～10%, dispersant 1%～10%, solvent 0～20%, defoamer 0.01%～2%, thickening agent 0～2%, antifreeze 0～8%, deionized water add to 100%.
Compositions includes following component and content when making microemulsion: active components A 1%～50%, active component B1%～50%, emulsifying agent 3%～25%, solvent 1%～10%, antifreeze 0～8%, defoamer 0.01%～2%, deionized water add to 100%.
Compositions includes following component and content when making aqueous emulsion: active components A 1%～50%, active component B1%～50%, solvent 1%～20%, emulsifying agent 1%～12%, antifreeze 0～8%, defoamer 0.01%～2%, thickening agent 0～2%, deionized water add to 100%.
Compositions includes following component and content when making microcapsule suspending agent: active components A 1%～50%, active component B1%～50%, macromolecule cyst material 1%～10%, dispersant 2%～10%, solvent 1%～10%, emulsifying agent 1%～7%, pH adjusting agent 0.01%～5%, defoamer 0.01%～2%, deionized water add to 100%.
Compositions includes following component and content when making microcapsule suspension-suspendinagent agent: active components A 1%～50%, active component B1%～50%, macromolecule cyst material 1%～12%, dispersant 1%-12%, wetting agent 1%-8%, solvent 1%～15%, emulsifying agent 1%～8%, defoamer 0.01%～2%, thickening agent 0～2%, pH adjusting agent 0.01%～5%, deionized water add to 100%.
The wettable powder the key technical indexes of the present invention:
The water dispersible granules the key technical indexes of the present invention:
The suspending agent the key technical indexes of the present invention:
The suspension emulsion the key technical indexes of the present invention:
The microemulsion the key technical indexes of the present invention:
The aqueous emulsion the key technical indexes of the present invention:
The microcapsule suspending agent the key technical indexes of the present invention:
The microcapsule suspension-suspendinagent agent the key technical indexes of the present invention:
It is an advantage of the current invention that:
(1) present composition has good potentiation and lasting effect within the specific limits, and preventive effect is higher than single dose；(2) pesticide usage amount reduces, and reduces pesticide residual quantity on crop, alleviates environmental pollution；(3) expand fungicidal spectrum, multiple diseases such as rice blast, leaf blight, bakanae disease, false smut, banded sclerotial blight, powdery mildew, rust, leaf spot, moire disease, net blotch, downy mildew, late blight, stripe disease are had greater activity.
Detailed description of the invention
Below in conjunction with embodiment to further instruction of the present invention, the percentage ratio in embodiment is all weight percentage, but the invention is not limited in this.
Application Example one: fluxapyroxad is correlated with compound product embodiment (following content is and amounts to percentage composition).
Example 1～14 wettable powder
By fluxapyroxad, effective ingredient B, dispersant, wetting agent, filler mixing, mix homogeneously in mixed cylinder, remix uniformly after jet mill is pulverized, namely can be made into wettable powder product of the present invention.It is specifically shown in table 1.
Table 1 example 1～14 each component and content
Example 15～24 water dispersible granules
Fluxapyroxad, effective ingredient B, dispersant, wetting agent, binding agent, disintegrating agent, filler are obtained through comminution by gas stream together the particle diameter needed, obtains granulation materials.Item is quantitatively sent in fluidized bed granulating dryer through granulating and dried, prepares water dispersible granules product of the present invention.It is specifically shown in table 2.
Table 2 example 15～24 each component and content
Example 25～34 suspending agent
By dispersant, wetting agent, defoamer, thickening agent, antifreeze through high speed shear mix homogeneously, add fluxapyroxad, effective ingredient B, surplus deionized water is supplied, ball milling 2～3 hours in ball mill, make diameter of particle all below 5 μm, prepare oil-suspending agent product of the present invention.It is specifically shown in table 3.
Table 3 example 25～34 each component and content
Example 35～39 suspension emulsion
By dispersant, defoamer, thickening agent, antifreeze, solvent in above-mentioned formulation material through high speed shear mix homogeneously, add fluxapyroxad, ball milling 2～3 hours in ball mill, make diameter of particle all below 5 μm, prepare fluxapyroxad suspending agent, then in active component B, emulsifying agent and the various direct emulsifying of auxiliary agent high speed agitator to suspending agent, suspension emulsion product of the present invention will be prepared.It is specifically shown in table 4.
Table 4 example 35～39 each component and content
Example 40～42 microemulsion
Fluxapyroxad, effective ingredient B are dissolved in equipped with in the homogenizer of solvent, emulsifying agent, antifreeze, defoamer are joined in the homogenizer equipped with above-mentioned solution, surplus deionized water strongly mixes after supplying and homogenizes, and finally obtains the microemulsion product of the present invention that clear appearance is transparent.It is specifically shown in table 5.
Table 5 example 40～42 each component and content
Example 43～52 aqueous emulsion
Fluxapyroxad, effective ingredient B, solvent, emulsifying agent are added together, make to be dissolved into homogeneous oil phase；Deionized water, antifreeze, thickening agent, defoamer are mixed, becomes homogeneous aqueous phase.Under high velocity agitation, aqueous phase is added oil phase, prepare aqueous emulsion product of the present invention.It is specifically shown in table 6.
Table 6 example 43～52 each component and content
Example 53～55 microcapsule suspending agent
By fluxapyroxad, active component B, macromolecule cyst material, solvent mixing, make to be dissolved into homogeneous oil phase, in a shear condition, oil phase is joined containing emulsifying agent, pH adjusting agent, dispersant, defoamer aqueous phase solution in, surplus deionized water is supplied, bi-material reacts at oil-water interfaces, forms macromolecule cyst wall, makes the finely disseminated microcapsule suspending agent product of the present composition.It is specifically shown in table 7.
Table 7 example 53～55 each component and content
Example 56,57 microcapsule suspension-suspendinagent agent
By active component B, macromolecule cyst material, solvent mixing, make to be dissolved into homogeneous oil phase, oil phase is joined in a shear condition containing emulsifying agent, pH adjusting agent aqueous phase solution in, make finely disseminated microcapsule suspending agent.By dispersant, wetting agent, defoamer, thickening agent through high speed shear mix homogeneously, add fluxapyroxad, ball milling 2～3 hours in ball mill, make diameter of particle all below 5 μm, prepare suspending agent, then being joined by suspending agent in the aqueous phase solution of micro-capsule suspension, deionized water supplies surplus, makes the finely disseminated microcapsule suspension-suspendinagent agent product of the present composition.It is specifically shown in table 8.
Table 8 example 56,57 each component and content
Active component B Isoprothiolane, fenoxanil, probenazole in table 1～8 are exchanged, novel formulation can be prepared.
The embodiment of the present invention is the method adopting Toxicity Determination and field test to combine.First pass through Toxicity Determination, potentiation ratio (SR) after clear and definite two kinds of medicaments are composite by a certain percentage, SR < 0.5 is antagonism, 0.5≤SR≤1.5 are summation action, SR > 1.5 is potentiation, on this basis, then carry out field test.
Test method: determine after the effective inhibition concentration scope of each medicament through prerun, medicament sets 5 dosage respectively and processes by active constituent content, if clear water comparison.Carry out with reference to " farm-chemical indoor determination test rule antibacterial ", adopt mycelial growth rate method to measure the medicament virulence to crop pathogenic bacteria.Measure colony diameter by decussation method after 72h, calculate each process net growth, mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), liquor strength (μ g/mL) converts logarithm value (x) to, try to achieve virulence regression equation (y=a+bx) with method of least square, and thus calculate the EC of every kind of medicament50Value.Calculating two medicaments different ratio synergy ratio (SR) according to Wadley method, SR < 0.5 is antagonism, and 0.5≤SR≤1.5 are summation action simultaneously, and SR > 1.5 is potentiation.Computing formula is as follows:
Wherein: the ratio that a, b respectively active components A and active component B are shared in combination；
A is fluxapyroxad；
B selects the one to Isoprothiolane, fenoxanil, probenazole.
Application Example two:
For examination disease: rice blast.
Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd..
EXPERIMENTAL DESIGN: determine effective inhibition concentration scope of fluxapyroxad and isoprothiolane and the two different ratio mixture through pilot study.
Table 9 fluxapyroxad and the composite toxicity test analysis of results table to rice blast of Isoprothiolane
As shown in Table 9, the potentiation ratio SR of rice blast is all higher than 1.5 when 1 80～60 1 by fluxapyroxad and Isoprothiolane proportioning, illustrate that both all show potentiation at mixture in 1 80～60 1 scopes, when the proportioning of fluxapyroxad and Isoprothiolane is when 1 25～5 1, potentiation is more prominent, and potentiation ratio is all more than 2.15.Especially when fluxapyroxad and Isoprothiolane weight ratio are 1:5, potentiation ratio is maximum, and potentiation is the most obvious.Testing, through applicant, the proportioning finding fluxapyroxad and Isoprothiolane is 5:1, 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, 1:11, 1:12, 1:13, 1:14, 1:15, 1:16, 1:17, 1:18, 1:19, 1:20, during 1:25, fluxapyroxad is composite to rice blast with Isoprothiolane, leaf blight, bakanae disease, false smut, banded sclerotial blight, powdery mildew, rust, leaf spot, moire disease, net blotch, downy mildew, late blight, the preventing and treating of stripe disease has obvious potentiation, potentiation ratio is all more than 1.50.
Application Example three:
For examination disease: rice blast.
Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd..
EXPERIMENTAL DESIGN: determine effective inhibition concentration scope of fluxapyroxad and the former medicine of fenoxanil and the two different ratio mixture through pilot study.
Toxicity test result
Table 10 fluxapyroxad and the composite toxicity test analysis of results table to rice blast of fenoxanil
As shown in Table 10, the potentiation ratio SR of rice blast is all higher than 1.5 when 1 80～60 1 by fluxapyroxad and fenoxanil proportioning, illustrate that both all show potentiation at mixture in 1 80～60 1 scopes, when the proportioning of fluxapyroxad and fenoxanil is when 1 20～10 1, potentiation becomes apparent from highlighting, and potentiation ratio is all more than 2.0.Especially when fluxapyroxad and fenoxanil weight ratio are 1:2, potentiation ratio is maximum, and potentiation is the most obvious.Testing, through applicant, the proportioning finding fluxapyroxad and fenoxanil is 10:1, 9:1, 8:1, 7:1, 6:1, 5:1, 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, 1:11, 1:12, 1:13, 1:14, 1:15, 1:16, 1:17, 1:18, 1:19, during 1:20, fluxapyroxad is composite to rice blast with fenoxanil, leaf blight, bakanae disease, false smut, banded sclerotial blight, powdery mildew, rust, leaf spot, moire disease, net blotch, downy mildew, late blight, the preventing and treating of stripe disease has obvious potentiation, potentiation ratio is all more than 1.50.
Application Example four:
For examination disease: Rice Leaf rot.
Test medicine provides by Shaanxi Welch Crop Protection Co., Ltd..
EXPERIMENTAL DESIGN: determine effective inhibition concentration scope of fluxapyroxad and the former medicine of probenazole and the two different ratio mixture through pilot study.
Toxicity test result
Table 11 fluxapyroxad and the composite toxicity test analysis of results table to Rice Leaf rot of probenazole
As shown in Table 11, the potentiation ratio SR of Rice Leaf rot is all higher than 1.5 when 1 80～60 1 by fluxapyroxad and probenazole proportioning, illustrate that both all show potentiation at mixture in 1 80～60 1 scopes, when the proportioning of fluxapyroxad and probenazole is when 1 35～5 1, potentiation becomes apparent from highlighting, and potentiation ratio is all more than 2.0.Especially when fluxapyroxad and probenazole weight ratio are 1:7, potentiation ratio is maximum, and potentiation is the most obvious.When the proportioning that applicant tests discovery fluxapyroxad and probenazole is 5:1,4:1,3:1,2:1,1:1,1:2,1:3,1:4,1:5,1:6,1:7,1:8,1:9,1:10,1:15,1:20,1:25,1:30,1:35, fluxapyroxad and probenazole composite to rice blast, leaf blight, bakanae disease, false smut, banded sclerotial blight, powdery mildew, rust, leaf spot, moire disease, net blotch, downy mildew, late blight, stripe disease preventing and treating have obvious potentiation, potentiation ratio is all more than 1.50.
Application Example five fluxapyroxad and active component B and the composite preventing and treating rice blast test of pesticide effectiveness thereof
This test arrangement is at Shaanxi Province's Hanzhong City; test medicine is researched and developed by Shaanxi Welch Crop Protection Co., Ltd., is provided, comparison medicament 10% fluxapyroxad suspending agent (autogamy), 40% Isoprothiolane cream (commercial), 20% fenoxanil suspending agent (commercial), 8% probenazole granule (commercial).
Investigating the rice blast state of an illness before medicine, in the first time dispenser of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after second time dispenser 7 days, 14 days, 30 days, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 12 fluxapyroxad and active component B and the composite preventing and treating rice blast test of pesticide effectiveness thereof
As can be seen from Table 12, effectively preventing and treating rice blast after fluxapyroxad is composite with active component B, prevention effect is superior to the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example six fluxapyroxad and active component B and composite prevent and treat the rice sheath blight disease test of pesticide effectiveness
This test arrangement is at Shaanxi Province's Hanzhong City; test medicine is researched and developed by Shaanxi Welch Crop Protection Co., Ltd., is provided, comparison medicament 10% fluxapyroxad suspending agent (autogamy), 40% Isoprothiolane cream (commercial), 20% fenoxanil suspending agent (commercial), 8% probenazole granule (commercial).
Investigating the rice sheath blight disease state of an illness before medicine, in the first time dispenser of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after second time dispenser 7 days, 14 days, 30 days, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 13 fluxapyroxad and active component B and composite prevent and treat the rice sheath blight disease test of pesticide effectiveness
As can be seen from Table 13, effectively preventing and treating rice sheath blight disease after fluxapyroxad is composite with active component B, prevention effect is superior to the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example seven fluxapyroxad and active component B and the composite preventing and treating wheat powdery mildew test of pesticide effectiveness thereof
This test arrangement is in Xi'an City, Shanxi Province; test medicine is researched and developed by Shaanxi Welch Crop Protection Co., Ltd., is provided, comparison medicament 10% fluxapyroxad suspending agent (autogamy), 40% Isoprothiolane cream (commercial), 20% fenoxanil suspending agent (commercial), 8% probenazole granule (commercial).
Investigating the wheat powdery mildew state of an illness before medicine, in the first time dispenser of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 3 times.Within after third time dispenser 7 days, 14 days, 30 days, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 14 fluxapyroxad and active component B and the composite preventing and treating wheat powdery mildew test of pesticide effectiveness thereof
As can be seen from Table 14, effectively preventing and treating wheat powdery mildew after fluxapyroxad is composite with active component B, prevention effect is superior to the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example eight fluxapyroxad and active component B and the composite preventing and treating wheat sharp eyespot test of pesticide effectiveness thereof
This test arrangement is in Baoji, Shaanxi province city; test medicine is researched and developed by Shaanxi Welch Crop Protection Co., Ltd., is provided, comparison medicament 10% fluxapyroxad suspending agent (autogamy), 40% Isoprothiolane cream (commercial), 20% fenoxanil suspending agent (commercial), 8% probenazole granule (commercial).
Investigating the wheat sharp eyespot state of an illness before medicine, in the first time dispenser of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after second time dispenser 7 days, 14 days, 30 days, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 15 fluxapyroxad and active component B and the composite preventing and treating wheat sharp eyespot test of pesticide effectiveness thereof
As can be seen from Table 15, effectively preventing and treating wheat sharp eyespot after fluxapyroxad is composite with active component B, prevention effect is superior to the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example nine fluxapyroxad and active component B and composite prevent and treat the wheat rust test of pesticide effectiveness
This test arrangement is in Jingyang County, Shaanxi Province; test medicine is researched and developed by Shaanxi Welch Crop Protection Co., Ltd., is provided, comparison medicament 10% fluxapyroxad suspending agent (autogamy), 40% Isoprothiolane cream (commercial), 20% fenoxanil suspending agent (commercial), 8% probenazole granule (commercial).
Investigating the wheat rust state of an illness before medicine, in the first time dispenser of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after second time dispenser 7 days, 14 days, 30 days, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 16 fluxapyroxad and active component B and composite prevent and treat the wheat rust test of pesticide effectiveness
As can be seen from Table 16, effectively preventing and treating wheat rust after fluxapyroxad is composite with active component B, prevention effect is superior to the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example ten fluxapyroxad and active component B and the composite preventing and treating rice blast test of pesticide effectiveness thereof
This test arrangement is in Hanzhong City suburb, Shaanxi Province; test medicine is researched and developed by Shaanxi Welch Crop Protection Co., Ltd., is provided, comparison medicament 10% fluxapyroxad suspending agent (autogamy), 40% Isoprothiolane cream (commercial), 20% fenoxanil suspending agent (commercial), 8% probenazole granule (commercial).
Investigating the rice blast state of an illness before medicine, in the first time dispenser of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after second time dispenser 7 days, 14 days, 30 days, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 17 fluxapyroxad and active component B and the composite preventing and treating rice blast test of pesticide effectiveness thereof
As can be seen from Table 17, effectively preventing and treating rice blast after fluxapyroxad is composite with active component B, prevention effect is superior to the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example 11 fluxapyroxad and active component B and the composite preventing and treating Folium Hordei Vulgaris rot test of pesticide effectiveness thereof
This test arrangement is in Jinchang City Yongchang County, Gansu Province; test medicine is researched and developed by Shaanxi Welch Crop Protection Co., Ltd., is provided, comparison medicament 10% fluxapyroxad suspending agent (autogamy), 40% Isoprothiolane cream (commercial), 20% fenoxanil suspending agent (commercial), 8% probenazole granule (commercial).
Investigating the Folium Hordei Vulgaris rot state of an illness before medicine, in the first time dispenser of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after second time dispenser 7 days, 14 days, 30 days, investigate disease index respectively and calculate preventive effect.Experimental result is as follows:
Table 18 fluxapyroxad and active component B and the composite preventing and treating Folium Hordei Vulgaris rot test of pesticide effectiveness thereof
As can be seen from Table 18, effectively preventing and treating Folium Hordei Vulgaris rot after fluxapyroxad is composite with active component B, prevention effect is superior to the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
After draw through tests different local throughout the country, after fluxapyroxad and Isoprothiolane, fenoxanil, probenazole are composite to the preventive effect of the Common Diseases such as the rice blast in various crop, leaf blight, bakanae disease, false smut, banded sclerotial blight, powdery mildew, rust, leaf spot, moire disease, net blotch, downy mildew, late blight, stripe disease all more than 95%, being better than single dose preventive effect, potentiation is obvious.
Claims (6)
1. the bactericidal composition of a Fluxapyroxad-containsterilization, it is characterized in that: effective active composition is active components A and active component B, active components A and active component B weight ratio are 1 80～60 1, and described active components A is fluxapyroxad, and active component B is probenazole.
2. the bactericidal composition of Fluxapyroxad-containsterilization according to claim 1, it is characterised in that: the weight ratio of active components A and active component B is 1 60～40 1.
3. the bactericidal composition of Fluxapyroxad-containsterilization according to claim 2, it is characterised in that: the weight ratio of fluxapyroxad and probenazole is 1 35～5 1.
4. the bactericidal composition of Fluxapyroxad-containsterilization according to claim 3, it is characterised in that: compositions makes wettable powder, water dispersible granules, suspending agent, suspension emulsion, microemulsion, aqueous emulsion, microcapsule suspending agent, microcapsule suspension-suspendinagent agent.
5. the bactericidal composition of Fluxapyroxad-containsterilization according to claim 4 is for preventing and treating the application of crop pest.
6. application according to claim 5, it is characterised in that: described disease is rice blast, leaf blight, bakanae disease, false smut, banded sclerotial blight, powdery mildew, rust, leaf spot, moire disease, net blotch, downy mildew, late blight, stripe disease.
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| CN101257798A (en) * | 2005-08-05 | 2008-09-03 | 巴斯福股份公司 | Fungicidal mixtures containing substituted 1-methyl pyrazol-4-yl carboxylic acid anilides |
| WO2009098223A2 (en) * | 2008-02-05 | 2009-08-13 | Basf Se | Plant health composition |
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| CN101257798A (en) * | 2005-08-05 | 2008-09-03 | 巴斯福股份公司 | Fungicidal mixtures containing substituted 1-methyl pyrazol-4-yl carboxylic acid anilides |
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