CN105770919A - Medical ultrasonic coupling agent for preventing skin disease infection - Google Patents
Medical ultrasonic coupling agent for preventing skin disease infection Download PDFInfo
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- CN105770919A CN105770919A CN201610209751.3A CN201610209751A CN105770919A CN 105770919 A CN105770919 A CN 105770919A CN 201610209751 A CN201610209751 A CN 201610209751A CN 105770919 A CN105770919 A CN 105770919A
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Abstract
The invention discloses a medical ultrasonic coupling agent for preventing skin disease infection. The medical ultrasonic coupling agent is composed of the following components in percentage by weight: 2-7% of traditional Chinese medicine extract, 70-82% of an optical clearing agent, 0.05-0.1% of a penetration enhancer, 0.5-1.5% of a viscosity modifier, 0.1-1.2% of a lubricating agent and the balance of deionized water. The traditional Chinese medicine extract is prepared by extracting the following traditional Chinese medicinal materials in parts by weight: 3-10 parts of desmodium gangeticum, 5-15 parts of sphagnum palustre, 5-20 parts of Siberian cocklebur flower, 4-10 parts of common sage herb, 3-8 parts of mangifera leaves, 3-8 parts of solanum lyratum thunb, 2-6 parts of oldworld arrowhead leaf, 1-5 parts of aeschynomene indica, 2-6 parts of erythrosticta maxim, 3-9 parts of adiantum capillus-veneris, 3-6 parts of cardamine hirsute, 1-6 parts of mazus japonicus, 1-5 parts of herb of java treebine, 2-7 parts of elsholtzia cypriani, 3-10 parts of anisomeles indica and 2-6 parts of lavender. On the basis of an ultrasonic coupling agent, a certain amount of traditional Chinese medicine extract is added, so that the medical ultrasonic coupling agent can effectively prevent cross infection of skin diseases such as eczema, scabies, furuncle and dermatitis, has no irritation to skin, is safe without toxic or side effect, good in imaging effect and high in image resolution.
Description
Technical field
The present invention relates to ultrasonic coupling agent technical field, be specifically related to a kind of medical ultrasonic coupling agent preventing the dermatosis from infecting.
Background technology
During ultrasonic examination, the air between probe and patient skin will hinder the incoming human body of ultrasound wave, for obtaining high-quality image, need fluidity transmitting medium to connect probe and patient's body surface, and this medium is exactly couplant.Couplant is a kind of easy-to-use product being made up of a new generation's aqueous high molecular gel.PH value is neutral, and human non-toxic is harmless in reply, is difficult to be dried, is difficult to become sour, and ultrasonoscopy is clear, and toughness is suitable, and without greasy, probe is prone to slide, and wettable skin eliminates skin surface air, and greasy property is good, it is easy to launch；, not damaged corrosion-free to ultrasonic probe；Non-stimulated to skin, without anaphylaxis, and easily wipe, there is good thixotropy and do not trickle, processing ease is grasped；Not pollution clothes, it is easy to clean；Good stability, is not affected by climate change.Can be used for A type, Type B, M type diasonograph, doppler flowmeter, it is adaptable to department of obstetrics and gynecology, digestive system, urinary system, nervous system, neonate, thyroid and mammary gland etc. check.
Existing medical ultrasonic coupling agent is widely used to hospital, for skin, tract mucosa ultrasound examination and intermediary's medium for the treatment of, each many employings of hospital clinical ultrasonic examination are based on the couplant of sodium carboxymethyl cellulose, methyl para hydroxy benzoic acid etc., although having certain coupling effect, but its anti-microbial property is poor, in clinical practice, the patient skin being checked can be produced certain corrosion and stimulation；Additionally, ultrasonic probe altofrequency in ultrasonic examination uses repeatedly between patient, it is generally only and does simple wiping after patient uses, although not necessarily making patient's thus infection pathogen, but still there is the risk of the biggest cross infection, when carrying out ultrasound detection, because ultrasonic probe must the skin of close contact patient just can check, many pathogenic bacterias can carry out cross infection by the damaged mouth of patient skin, especially detection position skin surface damages with wound or other forms, can bring cross infection to patient with ultrasonic examination.Therefore develop a kind of ultrasonic coupling agent that can prevent the dermatosis from infecting and there is highly important clinical meaning.
Summary of the invention
Present invention solves the technical problem that and be to provide a kind of medical ultrasonic coupling agent preventing the dermatosis from infecting, can effectively prevent and disease propagation, non-stimulated to human body, safe without toxic side effect, imaging effect is good, and image resolution ratio is high.
The technical scheme is that a kind of medical ultrasonic coupling agent preventing the dermatosis from infecting, calculation by weight, mainly consists of the following composition: Chinese medicine extract 2-7%, light clarifier 70-82%, penetrating agent 0.05-0.1%, viscosity modifier 0.5-1.5%, lubricant 0.1-1.2%, surplus are deionized water.
Further, described Chinese medicine extract is to be extracted by the Chinese crude drug of following weight portion to be prepared from: viscous people's grass 3-10 part, bog moss 5-15 part, Flos Xanthii 5-20 part, Herba Salviae Plebeiae 4-10 part, really leaf 3-8 part, Herba Solani Lyrati 3-8 part, Folium sagittariae sagittifoliae 2-6 part, Herba Aeschynonenes Indicae 1-5 part, Swertia erythrosticta Maxim. 2-6 part, Herba Adianti 3-9 part, Hairy Bittercress 3-6 part, Mazus japonicus 1-6 part, Herba Cissi Javanae 1-5 part, weeds perfume (or spice) 2-7 part, wide Radix Saposhnikoviae 3-10 part, Garden lavender 2-6 part.
Further, the preparation method of described Chinese medicine extract is:
nullFresh viscous people grass is weighed by described proportioning、Bog moss、Flos Xanthii、Herba Salviae Plebeiae、Really leaf、Herba Solani Lyrati、Folium sagittariae sagittifoliae、Herba Aeschynonenes Indicae、Swertia erythrosticta Maxim.、Herba Adianti、Hairy Bittercress、Mazus japonicus、Herba Cissi Javanae、Weeds is fragrant、Wide Radix Saposhnikoviae、Garden lavender，Clean up with the tap water of flowing，It is placed in 30-50 DEG C containing the warm water of the sodium chloride of 0.5-1% soaks 15-30min，Take out，Chopping，It is placed in juice extractor，And add equivalent ethanol and squeeze the juice，The mass concentration of described ethanol is 45-55%，Then filter to get filtrate，Filtrate heating is concentrated into the 1/3 of original volume，Cool after 30-34 DEG C addition water，Stirring，Water volume content is made to reach 65-68%，Activated carbon adsorption is decoloured，Then 18-20h is stood in 0-5 DEG C，Again with sodium bicarbonate solution regulation pH value to 7.0-8.0，Filter，Filtrate is condensed into the extractum that solid content is 72-75%，I.e. obtain described Chinese medicine extract；
Further, in such scheme, described smooth clarifier is PEG400, and light clarifier can now live to strengthen light penetration capacity in skin histology.
Further, in such scheme, described penetrating agent is azone, and it has stronger surface-active structure, also has the strongest compatibility, so skin matter is had the strongest osmosis.
Further, in such scheme, described viscosity modifier is carbomer, can not only regulate viscosity, also have good transparency.
A kind of medical ultrasonic coupling agent preventing the dermatosis from infecting, its preparation method is:
In a heated condition viscosity modifier is dissolved in light clarifier, adds deionized water and stir, be cooled to room temperature, add Chinese medicine extract, penetrating agent, lubricant stirring and dissolving, obtain described medical ultrasonic coupling agent.
The invention has the beneficial effects as follows: on the basis of existing ultrasonic coupling agent, add a certain amount of Chinese medicine extract, can effectively prevent dermatosis such as eczema, the cross infection of furuncle, dermatitis etc., non-stimulated to human body, safe without toxic side effect, imaging effect is good, and image resolution ratio is high.
Detailed description of the invention
Embodiment 1:
A kind of medical ultrasonic coupling agent preventing the dermatosis from infecting, calculation by weight, mainly consist of the following composition: Chinese medicine extract 2%, light clarifier 70%, penetrating agent 0.05%, viscosity modifier 0.5%, lubricant 0.1%, surplus are deionized water.
Wherein, described Chinese medicine extract is to be extracted by the Chinese crude drug of following weight portion to be prepared from: viscous people's grass 3 parts, bog moss 5 parts, Flos Xanthii 5 parts, Herba Salviae Plebeiae 4 parts, really 3 parts of leaf, Herba Solani Lyrati 3 parts, Folium sagittariae sagittifoliae 2 parts, Herba Aeschynonenes Indicae 1 part, Swertia erythrosticta Maxim. 2 parts, Herba Adianti 3 parts, Hairy Bittercress 3 parts, Mazus japonicus 1 part, Herba Cissi Javanae 1 part, fragrant 2 parts of weeds, wide Radix Saposhnikoviae 3 parts, Garden lavender 2 parts.
nullThe preparation method of described Chinese medicine extract is: weigh fresh viscous people grass by described proportioning、Bog moss、Flos Xanthii、Herba Salviae Plebeiae、Really leaf、Herba Solani Lyrati、Folium sagittariae sagittifoliae、Herba Aeschynonenes Indicae、Swertia erythrosticta Maxim.、Herba Adianti、Hairy Bittercress、Mazus japonicus、Herba Cissi Javanae、Weeds is fragrant、Wide Radix Saposhnikoviae、Garden lavender，Clean up with the tap water of flowing，It is placed in 30 DEG C containing the warm water of the sodium chloride of 0.5% soaks 15min，Take out，Chopping，It is placed in juice extractor，And add equivalent ethanol and squeeze the juice，The mass concentration of described ethanol is 45%，Then filter to get filtrate，Filtrate heating is concentrated into the 1/3 of original volume，Cool after 30 DEG C addition water，Stirring，Water volume content is made to reach 65%，Activated carbon adsorption is decoloured，Then 18h is stood in 0 DEG C，Again with sodium bicarbonate solution regulation pH value to 7.0，Filter，Filtrate is condensed into the extractum that solid content is 72%，I.e. obtain described Chinese medicine extract；
Wherein, described smooth clarifier is PEG400, and light clarifier can now live to strengthen light penetration capacity in skin histology.Described penetrating agent is azone, and it has stronger surface-active structure, also has the strongest compatibility, so skin matter is had the strongest osmosis.Described viscosity modifier is carbomer, can not only regulate viscosity, also have good transparency.
The preparation method of the medical ultrasonic coupling agent of this prevention the dermatosis from infecting is: be dissolved in by viscosity modifier in a heated condition in light clarifier, add deionized water to stir, it is cooled to room temperature, add Chinese medicine extract, penetrating agent, lubricant stirring and dissolving, obtain described medical ultrasonic coupling agent.
Embodiment 2:
A kind of medical ultrasonic coupling agent preventing the dermatosis from infecting, calculation by weight, mainly consists of the following composition: Chinese medicine extract 4.5%, light clarifier 76%, penetrating agent 0.075%, viscosity modifier 1.0%, lubricant 0.65%, surplus are deionized water.
Wherein, described Chinese medicine extract is to be extracted by the Chinese crude drug of following weight portion to be prepared from: viscous people's grass 6.5 parts, bog moss 10 parts, Flos Xanthii 12.5 parts, Herba Salviae Plebeiae 7 parts, really 5.5 parts of leaf, Herba Solani Lyrati 5.5 parts, Folium sagittariae sagittifoliae 4 parts, Herba Aeschynonenes Indicae 3 parts, Swertia erythrosticta Maxim. 4 parts, Herba Adianti 6 parts, Hairy Bittercress 4.5 parts, Mazus japonicus 3.5 parts, Herba Cissi Javanae 3 parts, fragrant 4.5 parts of weeds, wide Radix Saposhnikoviae 6.5 parts, Garden lavender 4 parts.
nullThe preparation method of described Chinese medicine extract is: weigh fresh viscous people grass by described proportioning、Bog moss、Flos Xanthii、Herba Salviae Plebeiae、Really leaf、Herba Solani Lyrati、Folium sagittariae sagittifoliae、Herba Aeschynonenes Indicae、Swertia erythrosticta Maxim.、Herba Adianti、Hairy Bittercress、Mazus japonicus、Herba Cissi Javanae、Weeds is fragrant、Wide Radix Saposhnikoviae、Garden lavender，Clean up with the tap water of flowing，It is placed in 40 DEG C containing the warm water of the sodium chloride of 0.75% soaks 22.5min，Take out，Chopping，It is placed in juice extractor，And add equivalent ethanol and squeeze the juice，The mass concentration of described ethanol is 50%，Then filter to get filtrate，Filtrate heating is concentrated into the 1/3 of original volume，Cool after 32 DEG C addition water，Stirring，Water volume content is made to reach 66.5%，Activated carbon adsorption is decoloured，Then 19h is stood in 2.5 DEG C，Again with sodium bicarbonate solution regulation pH value to 7.5，Filter，Filtrate is condensed into the extractum that solid content is 73.5%，I.e. obtain described Chinese medicine extract；
Wherein, described smooth clarifier is PEG400, and light clarifier can now live to strengthen light penetration capacity in skin histology.Described penetrating agent is azone, and it has stronger surface-active structure, also has the strongest compatibility, so skin matter is had the strongest osmosis.Described viscosity modifier is carbomer, can not only regulate viscosity, also have good transparency.
The preparation method of the medical ultrasonic coupling agent of this prevention the dermatosis from infecting is: be dissolved in by viscosity modifier in a heated condition in light clarifier, add deionized water to stir, it is cooled to room temperature, add Chinese medicine extract, penetrating agent, lubricant stirring and dissolving, obtain described medical ultrasonic coupling agent.
Embodiment 3:
A kind of medical ultrasonic coupling agent preventing the dermatosis from infecting, calculation by weight, mainly consist of the following composition: Chinese medicine extract 7%, light clarifier 82%, penetrating agent 0.1%, viscosity modifier 1.5%, lubricant 1.2%, surplus are deionized water.
Wherein, described Chinese medicine extract is to be extracted by the Chinese crude drug of following weight portion to be prepared from: viscous people's grass 10 parts, bog moss 15 parts, Flos Xanthii 20 parts, Herba Salviae Plebeiae 10 parts, really 8 parts of leaf, Herba Solani Lyrati 8 parts, Folium sagittariae sagittifoliae 6 parts, Herba Aeschynonenes Indicae 5 parts, Swertia erythrosticta Maxim. 6 parts, Herba Adianti 9 parts, Hairy Bittercress 6 parts, Mazus japonicus 6 parts, Herba Cissi Javanae 5 parts, fragrant 7 parts of weeds, wide Radix Saposhnikoviae 10 parts, Garden lavender 6 parts.
nullThe preparation method of described Chinese medicine extract is: weigh fresh viscous people grass by described proportioning、Bog moss、Flos Xanthii、Herba Salviae Plebeiae、Really leaf、Herba Solani Lyrati、Folium sagittariae sagittifoliae、Herba Aeschynonenes Indicae、Swertia erythrosticta Maxim.、Herba Adianti、Hairy Bittercress、Mazus japonicus、Herba Cissi Javanae、Weeds is fragrant、Wide Radix Saposhnikoviae、Garden lavender，Clean up with the tap water of flowing，It is placed in 50 DEG C containing the warm water of the sodium chloride of 1% soaks 30min，Take out，Chopping，It is placed in juice extractor，And add equivalent ethanol and squeeze the juice，The mass concentration of described ethanol is 55%，Then filter to get filtrate，Filtrate heating is concentrated into the 1/3 of original volume，Cool after 34 DEG C addition water，Stirring，Water volume content is made to reach 68%，Activated carbon adsorption is decoloured，Then 20h is stood in 5 DEG C，Again with sodium bicarbonate solution regulation pH value to 8.0，Filter，Filtrate is condensed into the extractum that solid content is 75%，I.e. obtain described Chinese medicine extract；
Wherein, described smooth clarifier is PEG400, and light clarifier can now live to strengthen light penetration capacity in skin histology.Described penetrating agent is azone, and it has stronger surface-active structure, also has the strongest compatibility, so skin matter is had the strongest osmosis.Described viscosity modifier is carbomer, can not only regulate viscosity, also have good transparency.
The preparation method of the medical ultrasonic coupling agent of this prevention the dermatosis from infecting is: be dissolved in by viscosity modifier in a heated condition in light clarifier, add deionized water to stir, it is cooled to room temperature, add Chinese medicine extract, penetrating agent, lubricant stirring and dissolving, obtain described medical ultrasonic coupling agent.
1, the ultrasonic coupling agent prepared by the embodiment of the present invention 1,2,3 is detected, measures its main physical and chemical index, the results are shown in Table 1:
2, product of the present invention carries out sterilization detection, and the killing rate for the common pathogenic bacteria such as gold-coloured staphylococci, escherichia coli, bacillus pyocyaneus, class product bacillus, Aspergillus flavus, Bacillus proteus, Candida albicans, hepatitis B virus all reaches more than 99.9%.
3, clinical verification: choose 300 experimenters immediately, is bisected into 3 groups, applies the ultrasonic coupling agent of embodiment 1,2,3 respectively on skin, sees whether anaphylaxis, and three groups any anaphylaxis all do not occur as a result.
4, conclusion: the ultrasonic coupling agent opposing antibacterial effect of the present invention is good, non-stimulated to human body, and safe without toxic side effect, allergy risk is low, and imaging effect is good, and image resolution ratio is high.
Above example is only for illustrating technology design and the feature of the present invention, and its object is to allow person skilled in the art is to will appreciate that present disclosure and implement according to this, can not limit the scope of the invention with this.All equivalent transformations done according to spirit of the invention or modification, all should contain within protection scope of the present invention.
Claims (7)
1. the medical ultrasonic coupling agent preventing the dermatosis from infecting, it is characterized in that, calculation by weight, mainly consists of the following composition: Chinese medicine extract 2-7%, light clarifier 70-82%, penetrating agent 0.05-0.1%, viscosity modifier 0.5-1.5%, lubricant 0.1-1.2%, surplus are deionized water.
A kind of medical ultrasonic coupling agent preventing the dermatosis from infecting the most as claimed in claim 1, it is characterized in that, described Chinese medicine extract is to be extracted by the Chinese crude drug of following weight portion to be prepared from: viscous people's grass 3-10 part, bog moss 5-15 part, Flos Xanthii 5-20 part, Herba Salviae Plebeiae 4-10 part, really leaf 3-8 part, Herba Solani Lyrati 3-8 part, Folium sagittariae sagittifoliae 2-6 part, Herba Aeschynonenes Indicae 1-5 part, Swertia erythrosticta Maxim. 2-6 part, Herba Adianti 3-9 part, Hairy Bittercress 3-6 part, Mazus japonicus 1-6 part, Herba Cissi Javanae 1-5 part, weeds perfume (or spice) 2-7 part, wide Radix Saposhnikoviae 3-10 part, Garden lavender 2-6 part.
A kind of medical ultrasonic coupling agent preventing the dermatosis from infecting the most as claimed in claim 2, it is characterised in that the preparation method of described Chinese medicine extract is:
nullFresh viscous people grass is weighed by described proportioning、Bog moss、Flos Xanthii、Herba Salviae Plebeiae、Really leaf、Herba Solani Lyrati、Folium sagittariae sagittifoliae、Herba Aeschynonenes Indicae、Swertia erythrosticta Maxim.、Herba Adianti、Hairy Bittercress、Mazus japonicus、Herba Cissi Javanae、Weeds is fragrant、Wide Radix Saposhnikoviae、Garden lavender，Clean up with the tap water of flowing，It is placed in 30-50 DEG C containing the warm water of the sodium chloride of 0.5-1% soaks 15-30min，Take out，Chopping，It is placed in juice extractor，And add equivalent ethanol and squeeze the juice，Then filter to get filtrate，Filtrate heating is concentrated into the 1/3 of original volume，Cool after 30-34 DEG C addition water，Stirring，Water volume content is made to reach 65-68%，Then 18-20h is stood in 0-5 DEG C，Again with sodium bicarbonate solution regulation pH value to 7.0-8.0，Filter，Filtrate is condensed into the extractum that solid content is 72-75%，I.e. obtain described Chinese medicine extract.
A kind of medical ultrasonic coupling agent preventing the dermatosis from infecting the most as claimed in claim 1, it is characterised in that described smooth clarifier is PEG400.
A kind of medical ultrasonic coupling agent preventing the dermatosis from infecting the most as claimed in claim 1, it is characterised in that described penetrating agent is thiophene ketone.
A kind of medical ultrasonic coupling agent preventing the dermatosis from infecting the most as claimed in claim 1, it is characterised in that described viscosity modifier is carbomer.
7. a kind of medical ultrasonic coupling agent preventing the dermatosis from infecting as described in claim 1-6, it is characterised in that preparation method is:
In a heated condition viscosity modifier is dissolved in light clarifier, adds deionized water and stir, be cooled to room temperature, add Chinese medicine extract, penetrating agent, lubricant stirring and dissolving, obtain described medical ultrasonic coupling agent.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107412792A (en) * | 2017-03-10 | 2017-12-01 | 安徽省伟业净化设备有限公司 | A kind of special ultrasonic wave-coupled agent of skin injury patient |
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