CN105770379A - 一种痔疮膏 - Google Patents

一种痔疮膏 Download PDF

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CN105770379A
CN105770379A CN201610184282.4A CN201610184282A CN105770379A CN 105770379 A CN105770379 A CN 105770379A CN 201610184282 A CN201610184282 A CN 201610184282A CN 105770379 A CN105770379 A CN 105770379A
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王永帮
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Abstract

一种痔疮膏，由以下重量份的原料制成：薄荷油28‑32份、冰片48‑52份、百合48‑52份、苍术42‑48份、黄连56‑62份、滑石30‑38份、赤石脂30‑38份、北柴胡42‑46份、石菖蒲54‑58份、独活48‑52份、田字草30‑34份、枇杷叶42‑46份、白扁豆38‑48份、五味子24‑32份、马齿苋42‑48份、西红花42‑46份、旱莲草42‑46份、蒲公英26‑30份、石钟乳34‑38份、金钱草25‑31份、山栀皮42‑46份、石荷叶38‑44份、毛冬青38‑44份、苍耳子42‑48份、白附子42‑48份、酸枣仁34‑38份、药用凡士林40‑50份。本发明痔疮膏直接从肛门给药，切近病灶，药效吸收快，起到活血去结，抗菌消炎，增强肌肉弹性的作用，防止肛瘘、肛裂，对于治疗外痔效果特别明显，治愈后不易复发，同时对于治疗便秘也有一定功效。

Description

一种痔疮膏
技术领域
本发明涉及医药制药技术领域，具体涉及一种痔疮膏。
背景技术
痔疮是肛门直肠底部及肛门粘膜的静脉丛发生曲张而形成的一个或多个柔软的静脉团的一种慢性疾病。通常当排便时持续用力，造成此处静脉内压力反复升高，静脉就会肿大。医学所指痔疮包括内痔、外痔、混合痔。
通常表现的症状包括：瘙痒，便血，疼痛。
痔疮的并发症：1.引起脱垂、顿甚至坏死，2.长期便血易致贫血，3.容易引发妇科炎症，4.导致肛周长期湿疹。
病发原因：
1.职业关系：人久站或久坐，长期负重远行，影响静脉回流，使盆腔内血流缓慢和腹内脏器充血，引起痔静脉过度充盈，静脉壁张力下降，血管容易瘀血扩张。又因运动不足、肠蠕动减少、粪便下行迟缓或习惯性便秘，可以压迫和刺激静脉，使局部充血和血液回流障碍，引起痔静脉内压力升高，静脉壁抵抗力降低。
2.局部刺激和饮食不节：肛门部受冷、受热、便秘腹泻、过量饮酒和多吃辛辣食物，都可刺激肛门和直肠，使痔静脉丛充血，影响静脉血液回流，以致静脉壁抵抗力下降。
3.肛门静脉压力增高：因肝硬，变肝充血和心脏功能代偿不全等，均可使肛门静脉充血，压力增高，影响直肠静脉血液回流。
4.腹内压力增加：因腹内肿瘤、子宫肿瘤、卵巢肿瘤、前列腺肥大、妊娠饮食过饱或蹲厕过久等。都可使腹内压增加妨碍静脉的血液回流。
5.肛门部感染：痔静脉丛先因急慢性感染，发炎静脉壁弹性组织逐渐纤维化而变弱，抵抗力不足，而致扩大曲张，加上其它原因使静脉曲张逐渐加重生成痔块。痔块主要由扩张静脉、海绵状组织和结缔组织间质构成。静脉扩张弯曲，其壁变薄，外膜和中层萎缩，壁内弹力纤维组织变成纤维组织也有的静脉无改变。静脉内可有血栓形成，静脉外有血块。常有急慢性炎症，可见因细胞浸润，有时形成小脓肿。海绵状组织，叫直肠海绵体，由很多血管小球组成，球内有短小并能弯曲的小动脉。有时有动静脉瘘，在痔块内可摸到动脉搏动。内痔表面是柱状上皮，外痔表面是鳞状上皮。
现在通常对于痔疮的治疗主要包括：手术和外敷。由于其病理特点，造成了其反复发作，治疗非常复杂。
发明内容
本发明所要解决的技术问题在于提供一种活血去结，抗菌消炎，增强肌肉弹性的作用，防止肛瘘、肛裂，对于治疗外痔效果特别明显的痔疮膏。
本发明所要解决的技术问题采用以下技术方案来实现：
一种痔疮膏，由以下重量份的原料制成：薄荷油28-32份、冰片48-52份、百合48-52份、苍术42-48份、黄连56-62份、滑石30-38份、赤石脂30-38份、北柴胡42-46份、石菖蒲54-58份、独活48-52份、田字草30-34份、枇杷叶42-46份、白扁豆38-48份、五味子24-32份、马齿苋42-48份、西红花42-46份、旱莲草42-46份、蒲公英26-30份、石钟乳34-38份、金钱草25-31份、山栀皮42-46份、石荷叶38-44份、毛冬青38-44份、苍耳子42-48份、白附子42-48份、酸枣仁34-38份、药用凡士林40-50份。
一种痔疮膏，优选的，由以下重量份的原料制成：薄荷油30份、冰片50份、百合50份、苍术45份、黄连59份、滑石34份、赤石脂34份、北柴胡44份、石菖蒲56份、独活50份、田字草32份、枇杷叶44份、白扁豆43份、五味子28份、马齿苋45份、西红花44份、旱莲草44份、蒲公英28份、石钟乳36份、金钱草28份、山栀皮44份、石荷叶41份、毛冬青41份、苍耳子45份、白附子45份、酸枣仁36份、药用凡士林45份。
一种痔疮膏的制备方法，包括以下步骤，
(1).按处方所述重量份称取各原料：薄荷油28-32份、冰片48-52份、百合48-52份、苍术42-48份、黄连56-62份、滑石30-38份、赤石脂30-38份、北柴胡42-46份、石菖蒲54-58份、独活48-52份、田字草30-34份、枇杷叶42-46份、白扁豆38-48份、五味子24-32份、马齿苋42-48份、西红花42-46份、旱莲草42-46份、蒲公英26-30份、石钟乳34-38份、金钱草25-31份、山栀皮42-46份、石荷叶38-44份、毛冬青38-44份、苍耳子42-48份、白附子42-48份、酸枣仁34-38份、药用凡士林40-50份；
(2).将各原料除薄荷油、冰片、滑石、赤石脂、药用凡士林外，加入10-20倍8°黄酒浸泡12小时，取出，沥干，再加入10-20倍52°的白酒煎煮2-5小时，过滤，滤渣再加入5-10倍52°的白酒煎煮2-5小时，过滤，合并两次滤液，滤液放入-40℃冷库冷冻24小时，取出，用文火煮开得备用液；
(3).将冰片、滑石、赤石脂研磨成20-50目的粉末，加入2-5倍浓度为40-50％的乙醇热回流30-50分钟，收取回流液，回流液减压回收乙醇得浸膏；
(4).将步骤(2)所得备用液和步骤(3)所得浸膏混合，加入薄荷油、药用凡士林充分混合均匀，加热蒸发得相对密度为1.65-1.75g/ml的稠膏；
(5).将步骤(4)所得稠膏放入杀菌锅灭菌，灭菌温度为83-87℃，然后灌装，每支3g，即得痔疮膏成品。
本发明痔疮膏使用时直接挤入肛门，每次一支，每晚睡前给药，15天一个疗程，一般2-3个疗程即可治愈。特别注意，本发明痔疮膏禁止接触脸部及皮肤有创口处。
本发明的有益效果是：本发明痔疮膏直接从肛门给药，切近病灶，药效吸收快，起到活血去结，抗菌消炎，增强肌肉弹性的作用，防止肛瘘、肛裂，对于治疗外痔效果特别明显，治愈后不易复发，同时对于治疗便秘也有一定功效。
具体实施方式
为了使本发明实现的技术手段、创作特征、达成目的与功效易于明白了解，下面结合具体实施例，进一步阐述本发明。
实施例1
一种痔疮膏，由以下重量份的原料制成：薄荷油30份、冰片50份、百合50份、苍术45份、黄连59份、滑石34份、赤石脂34份、北柴胡44份、石菖蒲56份、独活50份、田字草32份、枇杷叶44份、白扁豆43份、五味子28份、马齿苋45份、西红花44份、旱莲草44份、蒲公英28份、石钟乳36份、金钱草28份、山栀皮44份、石荷叶41份、毛冬青41份、苍耳子45份、白附子45份、酸枣仁36份、药用凡士林45份。
一种痔疮膏的制备方法，包括以下步骤，
(1).按处方所述重量份称取各原料；
(2).将各原料除薄荷油、冰片、滑石、赤石脂、药用凡士林外，加入15倍8°黄酒浸泡12小时，取出，沥干，再加入15倍52°的白酒煎煮3.5小时，过滤，滤渣再加入8倍52°的白酒煎煮3.5小时，过滤，合并两次滤液，滤液放入-40℃冷库冷冻24小时，取出，用文火煮开得备用液；
(3).将冰片、滑石、赤石脂研磨成40目的粉末，加入3.5倍浓度为45％的乙醇热回流40分钟，收取回流液，回流液减压回收乙醇得浸膏；
(4).将步骤(2)所得备用液和步骤(3)所得浸膏混合，加入薄荷油、药用凡士林充分混合均匀，加热蒸发得相对密度为1.7g/ml的稠膏；
(5).将步骤(4)所得稠膏放入杀菌锅灭菌，灭菌温度为85℃，然后灌装，每支3g，即得痔疮膏成品。
本发明痔疮膏使用时直接挤入肛门，每次一支，每晚睡前给药，15天一个疗程，一般2-3个疗程即可治愈。特别注意，本发明痔疮膏禁止接触脸部及皮肤有创口处。
实施例2
一种痔疮膏，由以下重量份的原料制成：薄荷油28份、冰片48份、百合48份、苍术42份、黄连56份、滑石30份、赤石脂30份、北柴胡42份、石菖蒲54份、独活48份、田字草30份、枇杷叶42份、白扁豆38份、五味子24份、马齿苋42份、西红花42份、旱莲草42份、蒲公英26份、石钟乳34份、金钱草25份、山栀皮42份、石荷叶38份、毛冬青38份、苍耳子42份、白附子42份、酸枣仁34份、药用凡士林40份。
一种痔疮膏的制备方法，包括以下步骤，
(1).按处方所述重量份称取各原料；
(2).将各原料除薄荷油、冰片、滑石、赤石脂、药用凡士林外，加入10倍8°黄酒浸泡12小时，取出，沥干，再加入10倍52°的白酒煎煮2小时，过滤，滤渣再加入5倍52°的白酒煎煮2小时，过滤，合并两次滤液，滤液放入-40℃冷库冷冻24小时，取出，用文火煮开得备用液；
(3).将冰片、滑石、赤石脂研磨成20目的粉末，加入2倍浓度为40％的乙醇热回流30分钟，收取回流液，回流液减压回收乙醇得浸膏；
(4).将步骤(2)所得备用液和步骤(3)所得浸膏混合，加入薄荷油、药用凡士林充分混合均匀，加热蒸发得相对密度为1.65g/ml的稠膏；
(5).将步骤(4)所得稠膏放入杀菌锅灭菌，灭菌温度为83℃，然后灌装，每支3g，即得痔疮膏成品。
本发明痔疮膏使用时直接挤入肛门，每次一支，每晚睡前给药，15天一个疗程，一般2-3个疗程即可治愈。特别注意，本发明痔疮膏禁止接触脸部及皮肤有创口处。
实施例3
一种痔疮膏，由以下重量份的原料制成：薄荷油32份、冰片52份、百合52份、苍术48份、黄连62份、滑石38份、赤石脂38份、北柴胡46份、石菖蒲58份、独活52份、田字草34份、枇杷叶46份、白扁豆48份、五味子32份、马齿苋48份、西红花46份、旱莲草46份、蒲公英30份、石钟乳38份、金钱草31份、山栀皮46份、石荷叶44份、毛冬青44份、苍耳子48份、白附子48份、酸枣仁38份、药用凡士林50份。
一种痔疮膏的制备方法，包括以下步骤，
(1).按处方所述重量份称取各原料；
(2).将各原料除薄荷油、冰片、滑石、赤石脂、药用凡士林外，加入20倍8°黄酒浸泡12小时，取出，沥干，再加入20倍52°的白酒煎煮5小时，过滤，滤渣再加入10倍52°的白酒煎煮5小时，过滤，合并两次滤液，滤液放入-40℃冷库冷冻24小时，取出，用文火煮开得备用液；
(3).将冰片、滑石、赤石脂研磨成50目的粉末，加入5倍浓度为50％的乙醇热回流50分钟，收取回流液，回流液减压回收乙醇得浸膏；
(4).将步骤(2)所得备用液和步骤(3)所得浸膏混合，加入薄荷油、药用凡士林充分混合均匀，加热蒸发得相对密度为1.75g/ml的稠膏；
(5).将步骤(4)所得稠膏放入杀菌锅灭菌，灭菌温度为87℃，然后灌装，每支3g，即得痔疮膏成品。
本发明痔疮膏使用时直接挤入肛门，每次一支，每晚睡前给药，15天一个疗程，一般2-3个疗程即可治愈。特别注意，本发明痔疮膏禁止接触脸部及皮肤有创口处。
临床资料：
随机抽取50例病人，年龄14-58岁，其中男性30例，女性20例。采用本发明具体实施例1的药物进行治疗。最终结果如下表所示。
由临床试验显示，本发明痔疮膏对痔疮治疗效果很好，尤其是适合治疗外痔。
疗效标准
依据1994年国家中医药管理局发布《中医病证诊断疗效标准》制订。治愈：排便时无出血；好转：排便时仍间断便血；无效：排便时仍便血。
以上显示和描述了本发明的基本原理和主要特征和本发明的优点。本行业的技术人员应该了解，本发明不受上述实施例的限制，上述实施例和说明书中描述的只是说明本发明的原理，在不脱离本发明精神和范围的前提下，本发明还会有各种变化和改进，这些变化和改进都落入要求保护的本发明范围内。本发明要求保护范围由所附的权利要求书及其等效物界定。

Claims (3)

1.一种痔疮膏，其特征在于，由以下重量份的原料制成：薄荷油28-32份、冰片48-52份、百合48-52份、苍术42-48份、黄连56-62份、滑石30-38份、赤石脂30-38份、北柴胡42-46份、石菖蒲54-58份、独活48-52份、田字草30-34份、枇杷叶42-46份、白扁豆38-48份、五味子24-32份、马齿苋42-48份、西红花42-46份、旱莲草42-46份、蒲公英26-30份、石钟乳34-38份、金钱草25-31份、山栀皮42-46份、石荷叶38-44份、毛冬青38-44份、苍耳子42-48份、白附子42-48份、酸枣仁34-38份、药用凡士林40-50份。
2.根据权利要求1所述的一种痔疮膏，其特征在于，由以下重量份的原料制成：薄荷油30份、冰片50份、百合50份、苍术45份、黄连59份、滑石34份、赤石脂34份、北柴胡44份、石菖蒲56份、独活50份、田字草32份、枇杷叶44份、白扁豆43份、五味子28份、马齿苋45份、西红花44份、旱莲草44份、蒲公英28份、石钟乳36份、金钱草28份、山栀皮44份、石荷叶41份、毛冬青41份、苍耳子45份、白附子45份、酸枣仁36份、药用凡士林45份。
3.如权利要求1所述的一种痔疮膏的制备方法，其特征在于：包括以下步骤，
(1).按处方所述重量份称取各原料；
(2).将各原料除薄荷油、冰片、滑石、赤石脂、药用凡士林外，加入10-20倍8°黄酒浸泡12小时，取出，沥干，再加入10-20倍52°的白酒煎煮2-5小时，过滤，滤渣再加入5-10倍52°的白酒煎煮2-5小时，过滤，合并两次滤液，滤液放入-40℃冷库冷冻24小时，取出，用文火煮开得备用液；
(3).将冰片、滑石、赤石脂研磨成20-50目的粉末，加入2-5倍浓度为40-50％的乙醇热回流30-50分钟，收取回流液，回流液减压回收乙醇得浸膏；
(4).将步骤(2)所得备用液和步骤(3)所得浸膏混合，加入薄荷油、药用凡士林充分混合均匀，加热蒸发得相对密度为1.65-1.75g/ml的稠膏；
(5).将步骤(4)所得稠膏放入杀菌锅灭菌，灭菌温度为83-87℃，然后灌装，每支3g，即得痔疮膏成品。
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