CN105770274A - Muscle regeneration plaster and preparation method thereof - Google Patents

Muscle regeneration plaster and preparation method thereof Download PDF

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Publication number
CN105770274A
CN105770274A CN201610154896.8A CN201610154896A CN105770274A CN 105770274 A CN105770274 A CN 105770274A CN 201610154896 A CN201610154896 A CN 201610154896A CN 105770274 A CN105770274 A CN 105770274A
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parts
ginseng
cream
blood
angelicae sinensis
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邢明宇
韩田田
邢远鹏
李国林
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/889Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
    • AHUMAN NECESSITIES
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    • A61K33/00Medicinal preparations containing inorganic active ingredients
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    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/34Copper; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/618Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11Pteridophyta or Filicophyta (ferns)
    • A61K36/12Filicopsida or Pteridopsida
    • A61K36/126Drynaria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/254Acanthopanax or Eleutherococcus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/35Caprifoliaceae (Honeysuckle family)
    • A61K36/355Lonicera (honeysuckle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/35Extraction with lipophilic solvents, e.g. Hexane or petrol ether

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
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Abstract

The invention discloses muscle regeneration plaster, prepared from the following medicinal materials according to parts by weight: 30-50 parts of ginseng, 30-100 parts of Radix Astragali, 30-100 parts of Radix Notoginseng, 30-100 parts of Radix Angelicae Sinensis, 20-50 parts of Rhizoma Drynariae, 20-50 parts of Resina Draconis, 500-1000 parts of refined sesame seed oil, 20-50 parts of Flos Lonicerae, 20-50 parts of Cortex Acanthopanacis Radicis, 20-40 parts of Margarita, 10-30 parts of verdigris, and 50-160 parts of yellow lead. The muscle regeneration plaster is effective in tonifying qi and activating blood, stopping bleeding and dissipating stasis, relieving pain and subsiding swelling, and is free of skin transplantation and significant in therapeutic effect for treating wounds with infection and purulence, bone exposure with healing failure healing and healing failure in long-term closure, such as trauma and burns.

Description

A kind of anathrepsis cream and preparation method thereof
Technical field
The invention belongs to pharmaceutical technology field, be specifically related to a kind of anathreptic Chinese medicine and preparation method thereof in wound, scald.
Background technology
In daily life, can wound unavoidably, the accident such as burn, traffic accident, industrial injury, causes bone fracture, comminuted fracture, muscle squeezes is pulverized, bedsore infects or exposes bone etc. because of deep burn.These cause bone exposure illness when hospitalize because of accident, generally require and carry out the operative treatment such as amputation or skin-grafting, not only operation difficulty is done, is bothered, treatment time length, weak effect, medical expense are high, patient suffering is big, and sequelae can be left because of amputation, skin-grafting etc. to patient, cause lifelong regret.There is no at present and make anathreptic medicine for treating exposed bone.
Publication number CN1231903A publication date 1999.10.20 discloses a kind of pharmaceutical composition making outer undisguised Surrounding muscles regenerate and preparation method thereof, and this pharmaceutical composition uses following ingredients and consumption (by weight) to be prepared from: red ginseng 50-120 part, radix pseudostellariae 60-80 part, honeysuckle 50-100 part, safflower 50-100 part, pangolin 60-90 part, scutellaria 60-90 part, pseudo-ginseng 70-120 part, coptis 60-90 part, wide red 50-100 part, sesame oil 500-800 part.Muscle damage, loss that treatment is caused because of burn, bedsore, scald, red wound, infection etc. by this medicine and the head without periosteum bone that causes exposes and has certain curative effect.But its result for the treatment of is limited, develop one can to wound, burn need not skin-grafting, situation about the most undisguisedly can not put on flesh realize anti-infective, remove slough, the medicine of quickly-healing be traditional Chinese medicine technology personnel need solve problem.
Summary of the invention
For solving the drawbacks described above that prior art exists, it is an object of the invention to provide a kind of anathrepsis cream used in wound, treatment of scald, the wound face infection such as red wound, wound, scald are suppurated, undisguisedly can not put on flesh, close the treatment do not healed for a long time, it is not necessary to skin-grafting, evident in efficacy.
Another object of the present invention is to provide the preparation method of a kind of anathrepsis cream.
For achieving the above object, the technical solution used in the present invention is: this anathrepsis cream, it is characterised in that prepare by the bulk drug of following weight parts: ginseng 30-50 part, Radix Astragali 30-100 part, pseudo-ginseng 30-100 part, Radix Angelicae Sinensis 30-100 part, rhizome of davallia 20-50 part, dragon's blood 20-50 part, little mill oil 500-1000 part, honeysuckle 20-50 part, cortex acanthopanacis 20-50 part, pearl 20-40 part, verdigris 10-30 part, yellow lead 50-160 part.
Preferably, this anathrepsis cream, it is characterised in that prepare by the bulk drug of following weight parts: ginseng 45 parts, the Radix Astragali 50 parts, pseudo-ginseng 50 parts, Radix Angelicae Sinensis 50 parts, the rhizome of davallia 40 parts, dragon's blood 40 parts, little mill oil 500 parts, honeysuckle 40 parts, field pennycress 40 parts, cortex acanthopanacis 40 parts, pearl 30 parts, verdigris 30 parts, 100 parts of yellow lead.
The preparation method of this anathrepsis cream, it is characterised in that be prepared according to the following steps:
(1) 150-250 degree is heated in first little mill oil being added iron pan, again by formula rate by ginseng, the Radix Astragali, pseudo-ginseng, Radix Angelicae Sinensis, the rhizome of davallia, that pot burned put into by honeysuckle, cortex acanthopanacis is black for degree, remove slag, impurity screening, continue little fire and boil, when the fluid boiled drips beading stop heating;
(2) oil liquid temperature be down to 80-120 spend time, add the yellow lead of formula rate, verdigris, pearl, fine powder of dragons blood, stir, cool as cream.
The using method of this anathrepsis cream, affected part cleaning and sterilizing, apply one layer with anathrepsis cream of the present invention, cover with gauze fixing, within 48 hours, again change.
Medicine of the present invention is applicant's several generations ancient prescription handed down from one's ancestors and improves gained through test of many times, the periosteum causing the muscle damage treated because burn, bedsore, scald, red wound, infection etc. cause, loss exposes and has peculiar curative effect, anti-infective, remove slough, wound healing is fast, it is not necessary to skin-grafting, and healing time is fast, topical application of drug can cover one layer of granulation on undisguised periosteum in three days, within 5-7 days, wound closes up, and within 7-10 days, the new skin in affected part grows up to, and this type of medicine of existing treatment is unable to reach as above effect.
In the present invention side of sending group medicine, ginseng, the Radix Astragali, pseudo-ginseng are monarch drug in a prescription, inrigorating qi and promoting blood circulation, the styptic powder stasis of blood, alleviating pain and detumescence.Ginseng has invigorating qi for relieving desertion, strengthening spleen and tonifying lung, peaceful heart intelligence development, and nourish blood the effect promoted the production of body fluid.Radix Astragali replenishing and restoring lung qi, inducing diuresis for removing edema, energy tonifying Qi is with promoting circulation of blood, and tonifying Qi is with green blood, and tonifying Qi is to nourish blood, and tonifying Qi is with logical numbness.Effect of its benefiting qi and nourishing blood, can make healthy tendency vigorous, after sore diabrosis, and not closing in for a long time etc., pus draining and toxin expelling, the effect of myogenic sore can be received.Pseudo-ginseng has the hemostasis of the scattered stasis of blood, effect of detumescence ding-tong, has good hemostasia effect, significant hematopoiesis function.Three taste monarch drug in a prescription compatibilities are mutually auxiliary to be multiplied, and the quickly-healing growth for muscle and skin provides guarantee.
Radix Angelicae Sinensis, the rhizome of davallia, dragon's blood are ministerial drug, have and enrich blood, saprophytic newly, swelling and pain relieving effect.Wherein, Radix Angelicae Sinensis is good at enriching blood, eliminating cold to stop pain, for the panacea enriched blood, can well treat the illness of qi-blood deficiency aspect with the tonifying Qi medicine Radix Astragali compatibility when using.Modern study shows, Radix Angelicae Sinensis has obvious inhibitory action to platelet aggregation, can reduce thrombosis;The Radix Angelicae Sinensis polysaccharide contained in Radix Angelicae Sinensis can make leucocyte and granulophilocyte increase, and the recovery to red blood cell, hemoglobin, leucocyte and femur number of nucleated cells has obvious facilitation, it is possible to strengthen hematopoiesis function.Rhizome of davallia energy promoting blood circulation to remove blood stasis, swelling and pain relieving, reunion of fractured tendons and bones, for the key medicine of traumatology.Allocating compound into, better efficacy, as the Holy Benevolent Prescriptions rhizome of davallia dissipates, with controlling metal-inflicted wound, injury of the tissues knochenbruch, aching unbearably painful, is i.e. scattered with this product compatibility native copper etc., and heat wine is taken after mixing with liquid, and has the effect of swelling and pain relieving, accelerating union of bone fracture.Dragon's blood has scattered stasis of blood analgesic therapy, hemostasis, effect of myogenic sore.
Little mill oil, honeysuckle, cortex acanthopanacis are adjutant, clearing heat and detoxicating, regulate the twelve regular channels, treat muscles and bones.Wherein, honeysuckle has effect clearing heat and detoxicating, that anti-inflammatory, qi-restoratives treat wind, cures mainly disease under turgor, warm disease heating, the heat poison disease such as large carbuncle and tumour.Cortex acanthopanacis function wines used as antirheumatic, again can filling liver kidney, strengthening the bones and muscles, can be used for the diseases such as arthralgia due to wind-dampness, muscles and bones contraction, soreness of waist and knee joint.Little mill oil is for blasting the effective ingredient of the medicine of frying, and action effect is more direct, good effect, containing abundant vitamin in the least mill oil, vitamin A therein, Cobastab, vitamin E etc., can stop fat to produce the harmful substance of infringement cell, purged body endotoxin.
Pearl, verdigris, yellow lead are for making medicine, and removing toxic substances and promoting tissue regeneration, desinsection is antipruritic, promoting granulation and wound healing.
The medicine that the present invention provides can be applicable to treatment because wounding, the red wound that causes of traffic accident, the accident such as industrial injury and the muscle loss infecting and causing because of burn or bedsore, bone the disease such as expose, promote its muscle and tendon regeneration.Medicine provided by the present invention proves through substantial amounts of clinic trial, has significant result for the treatment of.Not only can make muscle, tendon, skin regeneration, it is also possible to make wound restore, and the cycle of curing is short, patient suffering is little, postoperative without scar.Stop the sequelae such as amputation, skin-grafting.The diseases such as the exanthemv that the most also causes other reason, ulcer also have significant result for the treatment of.Bulk drug needed for the present invention is Chinese medicine conventional medicament, wide material sources, and preparation technology is simple, it is simple to implement.
Detailed description of the invention
Embodiment 1
A kind of anathrepsis cream, is prepared by the bulk drug of following weight parts: ginseng 30 parts, the Radix Astragali 30 parts, Radix Angelicae Sinensis 30 parts, pseudo-ginseng 30 parts, the rhizome of davallia 20 parts, dragon's blood 20 parts, little mill oil 500 parts, honeysuckle 20 parts, cortex acanthopanacis 20 parts, pearl 20 parts, verdigris 10 parts, 50 parts of yellow lead.
The preparation method of this anathrepsis cream, is prepared according to the following steps:
(1) 150 degree are heated in first little mill oil being added iron pan, again by formula rate by ginseng, the Radix Astragali, Radix Angelicae Sinensis, pseudo-ginseng, the rhizome of davallia, that pot burned put into by honeysuckle, cortex acanthopanacis is black for degree, remove slag, impurity screening, continue little fire and boil, when the fluid boiled drips beading stop heating;
(2) when oil liquid temperature is down to 80 degree, add the yellow lead of formula rate, verdigris, pearl, fine powder of dragons blood, stir, cool as cream.
Embodiment 2
A kind of anathrepsis cream, is prepared by the bulk drug of following weight parts: ginseng 45 parts, the Radix Astragali 50 parts, Radix Angelicae Sinensis 50 parts, pseudo-ginseng 50 parts, the rhizome of davallia 40 parts, dragon's blood 40 parts, little mill oil 500 parts, honeysuckle 40 parts, cortex acanthopanacis 40 parts, pearl 30 parts, verdigris 30 parts, 100 parts of yellow lead.
The preparation method of this anathrepsis cream, is prepared according to the following steps:
(1) 200 degree are heated in first little mill oil being added iron pan, again by formula rate by ginseng, the Radix Astragali, Radix Angelicae Sinensis, pseudo-ginseng, the rhizome of davallia, that pot burned put into by honeysuckle, cortex acanthopanacis is black for degree, remove slag, impurity screening, continue little fire and boil, when the fluid boiled drips beading stop heating;
(2) when oil liquid temperature is down to 100 degree, add the yellow lead of formula rate, verdigris, pearl, fine powder of dragons blood, stir, cool as cream.
Embodiment 3
A kind of anathrepsis cream, is prepared by the bulk drug of following weight parts: ginseng 50 parts, the Radix Astragali 100 parts, Radix Angelicae Sinensis 100 parts, pseudo-ginseng 100 parts, the rhizome of davallia 50 parts, dragon's blood 50 parts, little mill oil 1000 parts, honeysuckle 50 parts, cortex acanthopanacis 50 parts, pearl 40 parts, verdigris 30 parts, 160 parts of yellow lead.
The preparation method of this anathrepsis cream, it is characterised in that be prepared according to the following steps:
(1) 250 degree are heated in first little mill oil being added iron pan, again by formula rate by ginseng, the Radix Astragali, Radix Angelicae Sinensis, pseudo-ginseng, the rhizome of davallia, that pot burned put into by honeysuckle, cortex acanthopanacis is black for degree, remove slag, impurity screening, continue little fire and boil, when the fluid boiled drips beading stop heating;
(2) when oil liquid temperature is down to 120 degree, add the yellow lead of formula rate, verdigris, pearl, fine powder of dragons blood, stir, cool as cream.
Representative instance
Wang, man, fracture of lower leg, after county hospital orthopaedics synthetism, muscle cannot heal, and affected part reaches 3cmx5cm without muscle area, and affected part has white purulence to produce.First surgically by pus-serum wash clean white on marrow after seeing and treating patients, again with the ointment coating affected part of the embodiment of the present invention 1 preparation, and covered wrapping by gauze, changing dressings after 48 hours, within 7 days, muscle length is put down and closes up, and within 10 days, new skin generates, stop the topical application of drug, using bone fracture plaster treatment to promote the healing of bone again, after 30 days, x-ray fluoroscopy shows, bone healing success.

Claims (3)

1. an anathrepsis cream, it is characterised in that prepare by the bulk drug of following weight parts: ginseng 30-50 part, Radix Astragali 30-100 part, pseudo-ginseng 30-100 part, Radix Angelicae Sinensis 30-100 part, rhizome of davallia 20-50 part, dragon's blood 20-50 part, little mill oil 500-1000 part, honeysuckle 20-50 part, cortex acanthopanacis 20-50 part, pearl 20-40 part, verdigris 10-30 part, yellow lead 50-160 part.
2. anathrepsis cream as claimed in claim 1, it is characterised in that prepare by the bulk drug of following weight parts: ginseng 45 parts, the Radix Astragali 50 parts, pseudo-ginseng 50 parts, Radix Angelicae Sinensis 50 parts, the rhizome of davallia 40 parts, dragon's blood 40 parts, little mill oil 500 parts, honeysuckle 40 parts, field pennycress 40 parts, cortex acanthopanacis 40 parts, pearl 30 parts, verdigris 30 parts, 100 parts of yellow lead.
3. the preparation method of anathrepsis cream as claimed in claim 1, it is characterised in that be prepared according to the following steps:
(1) 150-250 degree is heated in first little mill oil being added iron pan, again by formula rate by ginseng, the Radix Astragali, pseudo-ginseng, Radix Angelicae Sinensis, the rhizome of davallia, that pot burned put into by honeysuckle, cortex acanthopanacis is black for degree, remove slag, impurity screening, continue little fire and boil, when the fluid boiled drips beading stop heating;
(2) oil liquid temperature be down to 80-120 spend time, add the yellow lead of formula rate, verdigris, pearl, fine powder of dragons blood, stir, cool as cream.
CN201610154896.8A 2016-03-18 2016-03-18 Muscle regeneration plaster and preparation method thereof Withdrawn CN105770274A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1231903A (en) * 1998-04-14 1999-10-20 徐志强 Medicine capable of regenerating muscle around exposed bone, and its preparing method
CN105535334A (en) * 2016-02-20 2016-05-04 胶州市人民中医医院 Radix arnebiae and milkvetch root granulation-promoting extract and preparation method

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1231903A (en) * 1998-04-14 1999-10-20 徐志强 Medicine capable of regenerating muscle around exposed bone, and its preparing method
CN105535334A (en) * 2016-02-20 2016-05-04 胶州市人民中医医院 Radix arnebiae and milkvetch root granulation-promoting extract and preparation method

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Application publication date: 20160720