CN105769943A - Method for extracting moringa oleifera flavone from moringa oleifera leaves and moringa oleifera healthcare product - Google Patents
Method for extracting moringa oleifera flavone from moringa oleifera leaves and moringa oleifera healthcare product Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/754—Evodia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Abstract
The invention belongs to the field of traditional Chinese medicine, and discloses a method for extracting moringa oleifera flavone from moringa oleifera leaves.The moringa oleifera leaves are washed up, dried and smashed; the powder is soaked with saturated whitewash for 20-60 min; after ethanol water is added, the pH value of the system is adjusted to be close to neutral, heating and extracting are carried out for more than 30 min, and the heating and extracting temperature is controlled to range from 50 DEG C to 70 DEG C; then pressure reducing suction filtration is carried out, and a total flavone extracting solution is obtained; evaporation and concentration are carried out, adsorption by macroporous resin is carried out, ethanol water is used for elution after washing, and eluant is obtained; evaporation and concentration are carried out, and moringa oleifera flavone is obtained after refrigerating and drying.Moringa oleifera flavone is openly prepared into a compound.The invention further discloses application of moringa oleifera flavone to preparation of a healthcare product with the effect of improving immunity.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of method extracting Moringa flavone from leaf of Moringa and application thereof.
Background technology
Immunity is the defense mechanism of human body self, it is human bioequivalence and any foreign body (virus, antibacterial etc.) eliminating external intrusion, processes the ability of old and feeble, damage, death, the own cells of degeneration and identification and process vivo mutations cell and virus infected cell.Immunology Today is thought, immunity is human bioequivalence and the physiological reaction getting rid of " dissident ".What perform this function in human body is immune system.Current Moringa health product composition is single, does not have due effect.Up to now, people are look for the Chinese medicine health care product of a kind of raising immunity making simple, taking convenience.
Summary of the invention
Goal of the invention: in order to solve the problems referred to above, it is an object of the invention to provide a kind of method extracting Moringa flavone from leaf of Moringa and application thereof.
Technical scheme: it is an object of the invention to by following scheme realization:
A kind of method extracting Moringa flavone from leaf of Moringa, cleans leaf of Moringa, dries, and pulverize；With saturated limewater pre-soaking 20～60min, after addition ethanol water, the acid-base value of regulation system is extremely close to neutral and more than heating extraction 30min, the temperature of heating extraction controls at 50～70 DEG C, then decompression sucking filtration obtains total flavones extracting solution, evaporation and concentration, obtains eluent with ethanol water eluting after macroporous resin adsorption, washing, evaporation and concentration, obtains total flavones and is Moringa flavone after freeze-dried.
Leaf of Moringa drying requirement is drying 3～7h at 40～70 DEG C of temperature.
Described macroporous resin is 10～60 orders the macroporous resin of cleaned D101, AB-8 or X-5.
A kind of have the Moringa health product improving immunity, its contained active component is prepared from by following raw materials in part by weight proportioning: Moringa flavone 2 parts, Foliumet Ramulus Evodiae 20 parts, 18 parts of rock jujube tree, big Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 16 parts, Herba passiflorae cochinchinensis 14 parts, Herba ixeritis debilis 20 parts, 6 parts of Radix Glycyrrhizae, and Moringa flavone is that said method preparation obtains.
Described have the Moringa health product improving immunity, preparation method step is: take above-mentioned other medical materials merging except Moringa flavone, boiling twice, collecting decoction, being concentrated into relative density when 65 DEG C is 1.10-1.20, add ethanol, stirring, makes alcohol content by volume percentage calculation reach 65-85%, stands, filter, when filtrate reduced in volume is to 65 DEG C, relative density is 1.20-1.30 and reclaims ethanol, and by concentrated solution spray drying, gained granular powder is broken into dry extract, add Moringa flavone and adjuvant, make required preparation.
Described have the Moringa health product improving immunity, and in preparation method, decocting condition is: first time amount of water is the 8-12 times amount of medical material weight, decocts 1-2h, and second time amount of water is the 6-10 times amount of medical material weight, decocts 1-2h.
Described have the Moringa health product improving immunity, and in preparation method, spray drying condition is: inlet temperature is 90-110 DEG C, and leaving air temp is 60-90 DEG C, and temperature of charge is 60-90 DEG C, and atomizing pressure is 0.2-0.5 MPa, and spray velocity is 1-10ml/s.
Described have the Moringa health product improving immunity application in preparation raising immunity health product.
Above-mentioned Moringa (MoringaoleiferaLam.) original producton location India and African Territories, for Moringaceae Moringa plant, undergraduate course only one belongs to, totally 14 kinds, evergreen or half defoliation small arbor plant.Because the root of Moringa has acid, so being named as " Moringa ", Moringa is also called " drumstick tree ", is because its trunk is gained the name as drumstick.The present invention is the leaf of Moringa of sajina tree (Moringaoleifera).
Foliumet Ramulus Evodiae derives from Rutaceae Evodia plant Foliumet Ramulus Evodiae Evodialepta (Spreng.) Merr., is used as medicine with root and leaf.The whole year can adopt, and root is cleaned, and section is dried standby；Leaf dries in the shade standby.Heat-clearing and toxic substances removing, expelling wind and removing dampness.Control the diseases such as laryngopharynx swelling and pain, rheumatic ostalgia, malaria, jaundice, eczema, dermatitis, traumatic injury and worm venom.
Rock jujube tree is plant Rhamnus heterophylla RhamnusheterophyllusOliv., is used as medicine with root or branch and leaf.Root can be adopted the whole year, and branch and leaf are adopted summer, dries clearing away heat-damp and promoting diuresis, cooling blood for hemostasis.For dysentery, spit blood, spitting of blood, bleeding hemorrhoids, metrorrhagia, leucorrhea, summer-heat day excessive thirst.The present invention is used as medicine with root.
Big Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) is Primulaceae Lysimachia plant Rhizoma Paridis Herba lysimachiae capillipedis LysimachiaparidiformaisFranch., with all herbal medicine.The four seasons can adopt, using fresh herb or dry.Perennial herb, high about 30 centimetres, up to 60 centimetres.Root stock tubbiness, supporting root is most, elongated, faint yellow.Stem is upright, not branch, and nearly base portion is red, has a pubescence, upper green or redly, dipped beam is sliding；Internode is longer, and joint place slightly expands, and has the flakey lobule of degeneration.Leaf is often four, nearly stockless, and wheel is born in stem top, wide ellipse, avette or ovum shape lanceolar.Summer-flowering, spends majority, clusters in stem top；Corolla yellow, slightly meat.Capsule is spherical, is coated in the calyx harbored.The chest stuffiness relieving profit diaphragm, eliminates the phlegm, antitussive, pain relieving.For pulmonary tuberculosis, chronic cough, gastroenteritis, stomachache, lumbago due to pathogenic wind-dampness, puerperal abdonimal pain；Traumatic injury, venom, furuncle and phyma are controlled in external.
Herba passiflorae cochinchinensis is Passifloraceae Passiflora plant Herba passiflorae cochinchinensis PassifloracochinchinensisSpreng., is used as medicine with Herb.The whole year can adopt, and cleans chopping, dries.Heat-clearing and toxic substances removing, reducing swelling and alleviating pain.For venom, taste-blindness rate；Panaris, carbuncle sore are controlled in external.
Herba ixeritis debilis is Compositae Ixeris Cass plant Herba ixeritis debilis IxerisdebilisA.Gray, with all herbal medicine.Xia Qiu gathers, using fresh herb or dry.Clearing away heat and cooling blood, inducing diuresis to remove edema.For cough due to lung-heat, laryngalgia, oral ulcer, acute conjunctivitis, appendicitis, edema, dysuria；Mastitis, furuncle toxic swelling, skin pruritus are controlled in external.All the other are pharmacopeia kind.
Beneficial effect: immunity is low is exactly positive QI-insufficiency by traditional Chinese medical science saying.Treatment is not only wanted qi-restoratives righting, also answers blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing.Therefore in we, Foliumet Ramulus Evodiae, rock jujube tree cooling blood for hemostasis, heat-clearing and toxic substances removing are monarch drug, big Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae), Herba passiflorae cochinchinensis heat-clearing and toxic substances removing, and reducing swelling and alleviating pain is ministerial drug, Moringa, Herba ixeritis debilis, Radix Glycyrrhizae inducing diuresis to remove edema, dispelling wind are adjuvant, all medicines are harmonious, and play benefiting QI for activating blood circulation altogether, are used for improving immunity.
Detailed description of the invention
Form by the following examples, the foregoing of the present invention is described in further detail again, but this should not being interpreted as, the scope of the above-mentioned theme of the present invention is only limitted to Examples below, and all technology realized based on foregoing of the present invention belong to the scope of the present invention.
Embodiment 1: take leaf of Moringa 1kg and clean, dry, and pulverize；With saturated limewater pre-soaking 20min, after addition ethanol water, the acid-base value of regulation system is extremely close to neutral and more than heating extraction 30min, the temperature of heating extraction controls at 70 DEG C, then decompression sucking filtration obtains total flavones extracting solution, evaporation and concentration, obtains eluent with ethanol water eluting after macroporous resin adsorption, washing, evaporation and concentration, obtains total flavones and is Moringa flavone after freeze-dried.Leaf of Moringa drying requirement is drying 7h at 40 DEG C of temperature.Described macroporous resin is 60 orders the macroporous resin of cleaned D101.
Embodiment 2: take leaf of Moringa 0.9kg and clean, dry, and pulverize；With saturated limewater pre-soaking 60min, after addition ethanol water, the acid-base value of regulation system is extremely close to neutral and more than heating extraction 30min, the temperature of heating extraction controls at 5070 DEG C, then decompression sucking filtration obtains total flavones extracting solution, evaporation and concentration, obtains eluent with ethanol water eluting after macroporous resin adsorption, washing, evaporation and concentration, obtains total flavones and is Moringa flavone after freeze-dried.Leaf of Moringa drying requirement is drying 3h at 70 DEG C of temperature.Described macroporous resin is 10 orders the macroporous resin of cleaned AB-8.
Embodiment 3: take leaf of Moringa 1.3kg and clean, dry, and pulverize；With saturated limewater pre-soaking 40min, after addition ethanol water, the acid-base value of regulation system is extremely close to neutral and more than heating extraction 30min, the temperature of heating extraction controls at 60 DEG C, then decompression sucking filtration obtains total flavones extracting solution, evaporation and concentration, obtains eluent with ethanol water eluting after macroporous resin adsorption, washing, evaporation and concentration, obtains total flavones and is Moringa flavone after freeze-dried.Leaf of Moringa drying requirement is drying 4h at 60 DEG C of temperature.Described macroporous resin is 40 orders the macroporous resin of cleaned X-5.
Embodiment 4: take Foliumet Ramulus Evodiae 20g, rock jujube tree 18g, big Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 16g, Herba passiflorae cochinchinensis 14g, Herba ixeritis debilis 20g, Radix Glycyrrhizae 6g medical material mixes, boiling twice, add water 8 times amount into medical material weight for the first time, decoct 1.5h, add water 6 times amount into medical material weight for the second time, decoct 1h, collecting decoction, filter, filtrate is concentrated into relative density 1.10 (65 DEG C), adding ethanol in proper amount makes alcohol content (volume fraction) reach 65%, stirring, stand 24 hours, filter, filtrate recycling ethanol is also concentrated into the extractum of relative density 1.10 (65 DEG C), it is spray-dried that (condition is inlet temperature is 100 DEG C, leaving air temp is 80 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s.), it is ground into dry extract, adds Moringa flavone 2g, the dextrin 50g of above-described embodiment 1 preparation, with appropriate 80% ethanol wet, soft material processed, cross 14 mesh sieves and granulate, 70 DEG C dry, and 60 order granulate obtain granule.
Embodiment 5: take Foliumet Ramulus Evodiae 20g, rock jujube tree 18g, big Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 16g, Herba passiflorae cochinchinensis 14g, Herba ixeritis debilis 20g, Radix Glycyrrhizae 6g medical material mixes, boiling twice, 10 times amount into medical material weight that add water, decoct 2h, add water 8 times amount into medical material weight for the second time, decoct 1h, collecting decoction, filter, filtrate is concentrated into relative density 1.15 (65 DEG C), adding ethanol in proper amount makes alcohol content (volume fraction) reach 75%, stirring, stand 24 hours, filter, filtrate recycling ethanol is also concentrated into the extractum of relative density 1.25 (65 DEG C), it is spray-dried that (condition is inlet temperature is 120 DEG C, leaving air temp is 90 DEG C, temperature of charge is 80 DEG C, atomizing pressure is 0.3 MPa, spray velocity is 7.5/s.), it being ground into dry extract, add Moringa flavone 2g, the starch 50g of above-described embodiment 1 preparation, mix homogeneously, with appropriate 80% ethanol wet, soft material processed, crosses 30 mesh sieves and granulates, dry in 70～80 DEG C, with 60 mesh sieve granulate, tabletting, sugar coating, subpackage, outer package, censorship is qualified, obtains finished product.
Embodiment 6: take Foliumet Ramulus Evodiae 20g, rock jujube tree 18g, big Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 16g, Herba passiflorae cochinchinensis 14g, Herba ixeritis debilis 20g, Radix Glycyrrhizae 6g medical material mixes, boiling twice, add water 10 times amount into medical material weight for the first time, decoct 1.5h, add water 8 times amount into medical material weight for the second time, decoct 1.5h, collecting decoction, filter, filtrate is concentrated into relative density 1.15 (65 DEG C), adding ethanol in proper amount makes alcohol content (volume fraction) reach 75%, stirring, stand 24 hours, filter, filtrate recycling ethanol is also concentrated into the extractum of relative density 1.25 (65 DEG C), it is spray-dried that (condition is inlet temperature is 120 DEG C, leaving air temp is 90 DEG C, temperature of charge is 90 DEG C, atomizing pressure is 0.4 MPa, spray velocity is 7.5/s.), be ground into dry extract, cross No. 6 sieves, add Moringa flavone 2g prepared by above-described embodiment 1, reinstall No. 1 capsule finished product.
Embodiment 7: the present invention improves the pharmacodynamic study of immunity
Experiment purpose: with the gavage mice 30d of the present invention of variable concentrations, compare the present invention and the normal group mice difference by the splenic lymphocyte proliferation of ConA induction, judge whether the present invention strengthens splenic lymphocyte proliferation.
Laboratory animal: Kunming mouse, male, body weight 18-22g, Shanghai Slac Experimental Animal Co., Ltd. provides, production licence: SCXK (Shanghai) 2007-0005.
Experimental agents: prepare by the preparation method of above-mentioned granule embodiment.
Experimental procedure: mice, is grouped by body weight stratified random, often group 12.As shown in the table, normal group gavage feeds water；Levamisole hydrochloride group gavage levamisole hydrochloride；The basic, normal, high dosage component of compound recipe other gavage 1,2,4g kg-1Inventive samples, the continuous gastric infusion 30d of each group.Aseptic taking spleen, conventionally make individual cells suspension, adjusting cell concentration is 5 × 105Individual/mL.Being added in 24 orifice plates by splenocyte suspension, every hole 1mL, every animal sets two multiple holes, and (adding 50uLPRMI1640 culture fluid) is normally cultivated in a hole；One hole adds 50uL concanavalin A, Con A (ConA) liquid (final concentration of 4.76ug/mL).It is placed in 5%CO2, 37 DEG C of CO2Incubator is cultivated 48h.Experiment terminates front 4h, and every hole sucks supernatant 700uL, adds the 700uL PRMI1640 culture fluid without hyclone, and every hole adds the MTT liquid of 50uL5mg/mL simultaneously.After cultivation terminates, every hole adds 1mL acid isopropyl alcohol, and the uniform crystallization to purple of careful piping and druming is all dissolved.Being dispensed in 96 well culture plates before detection, 4 multiple holes are made in every hole, measure its optical density value at 570nm wavelength place.
Experimental result: of the present invention group of mouse spleen lymphocyte is significantly higher than normal group mice by the rate of increase conversion values after ConA induction, as shown in the table.
Table 1 present invention on the impact of spleen lymphocyte proliferation (N=12)
Note: compared with normal group★★P < 0.01,★P < 0.05.
Conclusion: the present invention can strengthen spleen lymphocytic hyperplasia, therefore the present invention can improve immunity, can be used for preparation and improves efficacy of immunity health product.
Claims (8)
1. the method extracting Moringa flavone from leaf of Moringa, is characterized in that step is as follows: cleaned by leaf of Moringa, dry, and pulverizes；With saturated limewater pre-soaking 20～60min, after addition ethanol water, the acid-base value of regulation system is extremely close to neutral and more than heating extraction 30min, the temperature of heating extraction controls at 50～70 DEG C, then decompression sucking filtration obtains total flavones extracting solution, evaporation and concentration, obtains eluent with ethanol water eluting after macroporous resin adsorption, washing, evaporation and concentration, obtains total flavones and is Moringa flavone after freeze-dried.
2. the method extracting Moringa flavone as claimed in claim 1 from leaf of Moringa, is characterized in that leaf of Moringa drying requirement for drying 3～7h at 40～70 DEG C of temperature.
3. the method extracting Moringa flavone as claimed in claim 1 from leaf of Moringa, is characterized in that described macroporous resin is 10～60 orders the macroporous resin of cleaned D101, AB-8 or X-5.
4. one kind has the Moringa health product improving immunity, it is characterized in that, its contained active component is prepared from by following raw materials in part by weight proportioning: Moringa flavone 2 parts, Foliumet Ramulus Evodiae 20 parts, 18 parts of rock jujube tree, big Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 16 parts, Herba passiflorae cochinchinensis 14 parts, Herba ixeritis debilis 20 parts, 6 parts of Radix Glycyrrhizae, and the method preparation that Moringa flavone is the claims 1 obtains.
5. there are Moringa health product as claimed in claim 4 that improve immunity, it is characterized in that, preparation method step is: take above-mentioned other medical materials merging except Moringa polysaccharide, boiling twice, collecting decoction, being concentrated into relative density when 65 DEG C is 1.10-1.20, add ethanol, stirring, alcohol content by volume percentage calculation is made to reach 65-85%, stand, filter, when filtrate reduced in volume is to 65 DEG C, relative density is 1.20-1.30 and reclaims ethanol, by concentrated solution spray drying, gained granular powder is broken into dry extract, add Moringa flavone and adjuvant, make required preparation.
6. there are Moringa health product as claimed in claim 5 that improve immunity, it is characterized in that, in preparation method, decocting condition is: first time amount of water is the 8-12 times amount of medical material weight, decocts 1-2h, second time amount of water is the 6-10 times amount of medical material weight, decocts 1-2h.
7. there are Moringa health product as claimed in claim 5 that improve immunity, it is characterised in that in preparation method, spray drying condition is: inlet temperature is 90-110 DEG C, leaving air temp is 60-90 DEG C, temperature of charge is 60-90 DEG C, and atomizing pressure is 0.2-0.5 MPa, and spray velocity is 1-10ml/s.
8. there is the Moringa health product the improving immunity application in improving immunity health product as claimed in claim 4.
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| CN107373062A (en) * | 2017-09-01 | 2017-11-24 | 通江县石墩子生态农业有限公司 | A kind of preparation method of the chicken feed containing Moringa brass |
| CN108420074A (en) * | 2018-04-09 | 2018-08-21 | 江西牧威利元生物科技有限公司 | A kind of tyrosinase activity inhibitor and its application |
| CN116459286A (en) * | 2023-06-07 | 2023-07-21 | 河北瑞龙生物科技有限公司 | Method for extracting moringa flavone from moringa leaves |
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| 周玲仙: "《云南特有食物图鉴》", 31 March 2012, 云南科技出版社 * |
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| CN107373062A (en) * | 2017-09-01 | 2017-11-24 | 通江县石墩子生态农业有限公司 | A kind of preparation method of the chicken feed containing Moringa brass |
| CN108420074A (en) * | 2018-04-09 | 2018-08-21 | 江西牧威利元生物科技有限公司 | A kind of tyrosinase activity inhibitor and its application |
| CN116459286A (en) * | 2023-06-07 | 2023-07-21 | 河北瑞龙生物科技有限公司 | Method for extracting moringa flavone from moringa leaves |
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