CN105753719A - 一种盐酸曲恩汀化合物 - Google Patents
一种盐酸曲恩汀化合物 Download PDFInfo
- Publication number
- CN105753719A CN105753719A CN201410787042.4A CN201410787042A CN105753719A CN 105753719 A CN105753719 A CN 105753719A CN 201410787042 A CN201410787042 A CN 201410787042A CN 105753719 A CN105753719 A CN 105753719A
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- syprine hydrochloride
- syprine
- ray powder
- diffraction
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- 210000001519 tissue Anatomy 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/82—Purification; Separation; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/82—Purification; Separation; Stabilisation; Use of additives
- C07C209/86—Separation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (9)
Priority Applications (2)
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CN201610642758.4A CN106278907B (zh) | 2014-12-17 | 2014-12-17 | 一种盐酸曲恩汀化合物 |
CN201410787042.4A CN105753719B (zh) | 2014-12-17 | 2014-12-17 | 一种盐酸曲恩汀化合物 |
Applications Claiming Priority (1)
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CN201410787042.4A CN105753719B (zh) | 2014-12-17 | 2014-12-17 | 一种盐酸曲恩汀化合物 |
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CN201610642758.4A Division CN106278907B (zh) | 2014-12-17 | 2014-12-17 | 一种盐酸曲恩汀化合物 |
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CN105753719A true CN105753719A (zh) | 2016-07-13 |
CN105753719B CN105753719B (zh) | 2019-06-21 |
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CN201410787042.4A Ceased CN105753719B (zh) | 2014-12-17 | 2014-12-17 | 一种盐酸曲恩汀化合物 |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109239208A (zh) * | 2017-07-11 | 2019-01-18 | 四川科瑞德凯华制药有限公司 | 一种盐酸曲恩汀的质量检测方法 |
CN111479798A (zh) * | 2018-05-04 | 2020-07-31 | Gmp奥奋有限公司 | 三亚乙基四胺四盐酸盐的晶形及其医药用途 |
US11033579B2 (en) | 2015-09-24 | 2021-06-15 | Innolife Co., Ltd. | Use of trientine to deliver copper to ischemic tissue |
US11077138B2 (en) | 2015-04-22 | 2021-08-03 | Innolife Co., Ltd. | Methods of tissue repair and regeneration |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060041170A1 (en) * | 2004-07-19 | 2006-02-23 | Marco Jonas | Synthesis of triethylenetetramines |
WO2006104400A1 (en) * | 2005-03-26 | 2006-10-05 | Protemix Corporation Limited | Copper antagonist compositions |
CN102924289A (zh) * | 2012-11-07 | 2013-02-13 | 广东奥尔诚药业有限公司 | 一种盐酸曲恩汀的合成工艺 |
-
2014
- 2014-12-17 CN CN201610642758.4A patent/CN106278907B/zh active Active
- 2014-12-17 CN CN201410787042.4A patent/CN105753719B/zh not_active Ceased
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060041170A1 (en) * | 2004-07-19 | 2006-02-23 | Marco Jonas | Synthesis of triethylenetetramines |
WO2006104400A1 (en) * | 2005-03-26 | 2006-10-05 | Protemix Corporation Limited | Copper antagonist compositions |
CN102924289A (zh) * | 2012-11-07 | 2013-02-13 | 广东奥尔诚药业有限公司 | 一种盐酸曲恩汀的合成工艺 |
Non-Patent Citations (2)
Title |
---|
PURCHASE, RUPERT: "The purification of triethylenetetramine and its dihydrochloride for the treatment of Wilson’s disease", 《JOURNAL OF CHEMICAL RESEARCH》 * |
SUZUKI, TOSHIO等: "A simple and convenient preparation of triethylene tetramine dihydrochloride (trien) for the treatment of Wilson"s disease and its stability", 《BYOIN YAKUGAKU》 * |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11077138B2 (en) | 2015-04-22 | 2021-08-03 | Innolife Co., Ltd. | Methods of tissue repair and regeneration |
US11033579B2 (en) | 2015-09-24 | 2021-06-15 | Innolife Co., Ltd. | Use of trientine to deliver copper to ischemic tissue |
CN109239208A (zh) * | 2017-07-11 | 2019-01-18 | 四川科瑞德凯华制药有限公司 | 一种盐酸曲恩汀的质量检测方法 |
CN111479798A (zh) * | 2018-05-04 | 2020-07-31 | Gmp奥奋有限公司 | 三亚乙基四胺四盐酸盐的晶形及其医药用途 |
US10988436B2 (en) | 2018-05-04 | 2021-04-27 | Orphalan S.A. | Crystalline form of triethylenetetramine tetrahydrochloride and its pharmaceutical use |
US11072577B2 (en) | 2018-05-04 | 2021-07-27 | Orphalan S.A. | Crystalline form of triethylenetetramine tetrahydrochloride and its pharmaceutical use |
US11117855B2 (en) | 2018-05-04 | 2021-09-14 | Orphalan S.A. | Crystalline form of triethylenetetramine tetrahydrochloride and its pharmaceutical use |
Also Published As
Publication number | Publication date |
---|---|
CN106278907B (zh) | 2019-06-21 |
CN105753719B (zh) | 2019-06-21 |
CN106278907A (zh) | 2017-01-04 |
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