CN105749232A - Folium artemisiae argyi-containing traditional Chinese medicine formula for tonifying kidney yang and nourishing kidney yin - Google Patents
Folium artemisiae argyi-containing traditional Chinese medicine formula for tonifying kidney yang and nourishing kidney yin Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/40—Cornaceae (Dogwood family)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/638—Ligustrum, e.g. Chinese privet
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention belongs to the field of traditional Chinese medicines and relates to a folium artemisiae argyi-containing traditional Chinese medicine formula for tonifying kidney yang and nourishing kidney yin. The traditional Chinese medicine formula is prepared from the following raw materials in parts by weight: 21-27 parts of folium artemisiae argyi, 19-26 parts of radix saposhnikoviae, 17-22 parts of poria cocos, 15-21 parts of radix achyranthis bidentatae, 16-22 parts of ligusticum wallichii, 10-16 parts of semen cuscutae, 9-15 parts of glossy privet fruit, 12-16 parts of angelica sinensis, 13-18 parts of cornus officinalis, 9-15 parts of lycium barbarum, 10-16 parts of ginger and 7-12 parts of liquorice. The traditional Chinese medicine formula provided by the invention has the functions of dredging channels and activating collaterals, activating blood and moving qi and tonifying and replenishing the liver and kidneys, and realizes a remarkable curative effect on kidney-deficiency syndrome. Animal experiments prove that the traditional Chinese medicine formula provided by the invention can remarkably improve the constitution and immunity of rats suffering the kidney-deficiency syndrome, and realizes a noticeable treatment effect on the rats suffering the kidney-deficiency syndrome.
Description
Technical field
The invention belongs to the field of Chinese medicines, particularly relate to the Chinese medicinal formulae of a kind of kidney-replenishing nourishing kidney-yin containing tarragon.
Background technology
Finger kidney vital essence negative and positive of suffering from a deficiency of the kidney are not enough.The kind suffered from a deficiency of the kidney has a lot, and most common of which is kidney-yin deficiency, kidney-yang deficiency.The symptom suffered from a deficiency of the kidney: kidney
The symptom of the deficiency of yang is the soreness of waist, coldness of extremities, chilly, the most also oedema, and for the symptom of " trembling with fear ", property function is bad also results in kidney-yang deficiency；Kidney
The symptom of the deficiency of Yin is " hot ", mainly has the soreness of waist, scorching, night sweat, abnormal sweating, dizziness, tinnitus etc..Modern science proves, when people suffers from a deficiency of the kidney,
No matter kidney-yin deficiency or kidney-yang deficiency, all can cause the reduction of the immunocompetence of people, have more evidence to show, suffer from a deficiency of the kidney generation time, the immunity energy of kidney
Power reduces, and the microcirculqtory system of kidney also can be blocked, and kidney network presents obstructed.So the treatment for suffering from a deficiency of the kidney should prevent and treat combination.
The great achievement of medical science before "Nei Jing", Difficult Classic Ji Qinhan, establishes to hide as the basic theory system as core, and physiology, the cause of disease,
The theories that aspect is asthenic symptoms such as pathology, disease, the rules for the treatment of and health-preserving and disease-preventing have established solid foundation." Plain Questions is logical comments actual situation opinion " proposes " vital essence
Take by force then empty " viewpoint, it is believed that vital essence loss is the premise of asthenic symptoms." Plain Questions innocence in ancient times opinion " summarizes and is dominated by the vital essence prosperity and decline of kidney, control, raw
Order by gradually containing to containing strong, the natural course of degradation again.These are summed up, and the most having recognized from physiological angle suffers from a deficiency of the kidney shows from the beginning of before and after 40 years old, with year
Constantly the increasing and the most substantially highlight of age, in today, the biotical growth of "Nei Jing" is strengthened the description of old rule and is still conformed to actual state.This
In also reveal that simultaneously and suffer from a deficiency of the kidney and old and feeble inner link.The research of Yao Peifa etc. shows, the percentage that normal adults is suffered from a deficiency of the kidney with increase age and in growth
Trend, 40 years old, 50 years old, 60 years old, the nephrasthenia syndrome occurrence rate of 70 years old age group be 71%, 80%, 95%, 96% respectively.
On the basis of forefathers recognize, Qing Dynasty Lin Peiqin clearly summarize suffer from a deficiency of the kidney, the pathological concept such as kidney-yang deficiency, kidney deficiency in both YIN and YANG, corresponding arteries and veins disease table
Existing and concrete treatment side's medicine.As " ache of the spinal column, continuous has a pain, and join legs the aching and limp person of foot, suffers from a deficiency of the kidney also." " kidney-yang deficiency person, weak pulse is without carefully, and urine is clear
Profit, god is tired to breathe hard, preferably the source of benefit fire, shenqi pill, pilose antler ball." " kidney-yin deficiency person, arteries and veins is big vast and counts, scorching during the fire of deficiency type, and dark urine preferably strengthens the master of water,
Dihuang Decoction, Da Bu Wan." " kidney deficiency in both YIN and YANG person, feeble pulse and big, suitable extreme misery Heibei provincial opera, Wubishanyao Pills." these pathological concept and side medicine edge always
With so far, instruct theory and the clinical practice of the traditional Chinese medical science.
Chinese patent application 201510336173.5 discloses the Chinese medicine that a kind for the treatment of is suffered from a deficiency of the kidney, be by maple ball 4-7, black fungus 6-8, the sub-7-10 of paper mulberry,
Radix stellariae dichotomae 6-9, beggar-ticks 5-8, Radix Codonopsis 3-6, matrimony vine 4-6, golden cypress 7-9, Chinese yam 3-5, Radix Angelicae Sinensis 4-7, parasitic loranthus 5-8, lily 2-4, Ba Ji
It 8-10, fructus amomi 10-12, bark of eucommia 6-8 are prepared from, and this invention Chinese medicine clinic can be treated and be suffered from a deficiency of the kidney.This Chinese medicine has nourishing the liver invigorating the spleen, marrow mended by controlling nocturnal emission with astringent drugs,
Effect that soothing the liver fall fire, nourshing kidney are invigorated blood circulation, but complicated component, theoretical foundation is indefinite, without prescription analysis.
Summary of the invention
The technical problem to be solved in the present invention is to provide the Chinese medicinal formulae of a kind of kidney-replenishing nourishing kidney-yin, in particular it relates to a kind of kidney-replenishing containing tarragon
The Chinese medicinal formulae of nourishing kidney-yin.This Chinese medicinal formulae has clearing and activating the channels and collaterals, blood-activating and qi-promoting, and the effect such as tonify the liver and kidney, and also has good effect, has no side effect
With advantages such as taking conveniences.Additionally, the present invention also provide for corresponding manufacturing process by this Chinese medicinal formulae ensure to make on the premise of curative effect facilitate easy-to-use
Preparation.
For achieving the above object, technical scheme is as follows:
Chinese medicinal formulae of the present invention is prepared from by the raw material of following parts by weight:
Tarragon 21-27 part, windproof 17-22 part, Poria cocos 19-26 part, root of bidentate achyranthes 15-2l part, Ligusticum wallichii 16-22 part, seed of Chinese dodder 10-16 part, glossy privet
Sub-9-15 part, Radix Angelicae Sinensis 12-16 part, Fructus Corni 13-18 part, matrimony vine 9-15 part, ginger 10-16 part and Radix Glycyrrhizae 7-12 part.
Further, described Chinese medicinal formulae is prepared from by the raw material of following parts by weight:
Tarragon 21 parts, windproof 17 parts, 19 parts of Poria cocos, the root of bidentate achyranthes 15 parts, Ligusticum wallichii 16 parts, the seed of Chinese dodder 10 parts, the fruit of glossy privet 9 parts, Radix Angelicae Sinensis 12
Part, Fructus Corni 13 parts, matrimony vine 9 parts, 10 parts of ginger and 7 parts of Radix Glycyrrhizae.
Further, described Chinese medicinal formulae is prepared from by the raw material of following parts by weight:
Tarragon 27 parts, windproof 22 parts, 26 parts of Poria cocos, the root of bidentate achyranthes 21 parts, Ligusticum wallichii 22 parts, the seed of Chinese dodder 16 parts, the fruit of glossy privet 15 parts, Radix Angelicae Sinensis 16
Part, Fructus Corni 18 parts, matrimony vine 15 parts, 16 parts of ginger and 12 parts of Radix Glycyrrhizae.
Further, described Chinese medicinal formulae is prepared from by the raw material of following parts by weight:
Tarragon 24 parts, windproof 20 parts, 22 parts of Poria cocos, the root of bidentate achyranthes 18 parts, Ligusticum wallichii 19 parts, the seed of Chinese dodder 13 parts, the fruit of glossy privet 12 parts, Radix Angelicae Sinensis 14
Part, Fructus Corni 15 parts, matrimony vine 12 parts, 13 parts of ginger and 9 parts of Radix Glycyrrhizae.
Correspondingly, the preparation method of described Chinese medicinal formulae comprises following step:
S1, weigh each taste raw medicinal material in proportion；
S2, tarragon, windproof, Poria cocos, the root of bidentate achyranthes, Ligusticum wallichii, the seed of Chinese dodder, the fruit of glossy privet, Radix Angelicae Sinensis, Fructus Corni, matrimony vine, ginger and Radix Glycyrrhizae are gone respectively
Impurity, cleans, and dries, is ground into meal；
S3, the ingredients meal mixing prepared by S2, add the distilled water of initial 5-8 times of weight of medicinal material, soak 12-20 hour, decoct 2-4
Hour, filter and retain filtrate；Add the purified water of initial 6-9 times of weight of medicinal material, decoct 1-3 hour, filter and retain filter residue；Merge filter
Liquid, is concentrated into the concentrate that 60-70 DEG C of relative density is 1.20-1.25 standby；
S4, ethanol toward concentration 65-75% adding 4-7 times of weight in the filter residue of S3, refluxing extraction 2-3 time, each 2-5 hour, filtration was also
Retaining filtrate, merging filtrate, decompression is distilled off ethanol, and it is standby to be concentrated into the concentrate that 60-70 DEG C of relative density is 1.20-1.25；
S5, the concentrate of S3 and S4 gained is merged, continue to be concentrated into the Chinese medical concrete that 60-70 DEG C of relative density is 1.30-1.35, standby；
S6, toward the Chinese medical concrete of S5 gained adds auxiliary material, utilize modern general Chinese medicine preparation technology to make the finished product preparation of clinical needs.
Further, described Chinese medicinal formulae is made into capsule, tablet, powder, oral liquid, granule or pill.
The source of component used by the present invention, nature and flavor, return through and effect:
Tarragon: for the dry leaf of feverfew Chinese mugwort；Taste is pungent, bitter, warm in nature, returns liver,spleen,kidney warp；Warming channel for arresting bleeding, eliminating cold to stop pain, menstruation regulating is pacified
Tire, removing dampness to relieve itching, clearing and activating the channels and collaterals.
Windproof: for the dry root of umbelliferae Saposhnikovia divaricata；Taste is pungent, sweet, warm in nature；Return bladder, liver, the spleen channel；Inducing diaphoresis to dispel wind, wins wet, only convulsion.
Poria cocos: for the dry sclerotia of On Polyporaceae Poria cocos；Taste is sweet, light, and property is put down；The thoughts of returning home, lung, spleen, kidney channel；Clearing damp and promoting diuresis, invigorating the spleen is peaceful
The heart.
The root of bidentate achyranthes: for the dry root of the amaranthaceous plant root of bidentate achyranthes；Bitter, acid, property is put down；Return liver, kidney channel；Filling liver kidney, strengthening the bones and muscles, stimulate the menstrual flow by the stasis of blood, draw blood
Descending.
Ligusticum wallichii: for the dry rhizome of samphire Ligusticum wallichii；Taste is pungent, warm in nature；Return liver, courage, pericardium channel；Blood-activating and qi-promoting, wind-expelling pain-stopping.
The seed of Chinese dodder: for the dry mature seed of convolvulus cuscuta plant；Taste is sweet, warm in nature；Return liver,kidney,spleen warp；Nourishing liver and kidney, controlling nocturnal emission with astringent drugs contracting urine,
Antiabortive, improving eyesight, antidiarrheal.
The fruit of glossy privet: for the fruit of Oleaceae Ligustrum plant glossy privet；Taste is sweet, bitter, cool in nature；Return liver, kidney channel；Tonify the liver and kidney, improving eyesight, clearind deficient heat.
Radix Angelicae Sinensis: for the dry root of umbelliferae angelica；Its taste is sweet, pungent, warm in nature；Return liver, the heart, the spleen channel；Inrigorating qi and promoting blood circulation, menstruction regulating and pain relieving, profit
Intestines defaecation.
Fructus Corni: for the drying and ripening pulp of Cornaceae plant Fructus Corni；Taste is sour, puckery, slightly warm in nature；Return liver, kidney channel；Tonify the liver and kidney, puckery essence
Gu it is de-.
Matrimony vine: for the dry mature fruit of plant of Solanaceae lycium barbarum；Its taste is sweet, and property is put down；Return liver, kidney channel；Nourshing kidney, moistening lung, tonifying liver, improving eyesight.
Ginger: for the fresh rhizome of zingiber；Taste is pungent, slightly warm in nature；Return lung, spleen, stomach warp；Relieving exterior syndrome and dispelling cold, warming middle energizer to arrest vomiting, preventing phlegm from forming and stopping coughing.
Radix Glycyrrhizae: this product is glycyrrhizic legume, swollen fruit Radix Glycyrrhizae or the dry root of glycyrrhiza glabra.Taste is sweet, and property is put down；The thoughts of returning home, lung, spleen, stomach warp；Mend
Spleen benefit gas, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.
The prescription analysis of Chinese medicine of the present invention:
According to the compatibility theory of the traditional Chinese medical science dialectical and Chinese medicine to having kidney-replenishing nourishing kidney-yin effect, in conjunction with fitness and the modern pharmaceutical skill of modern
The feature of art, the collocation ingredients of reasonable science, form Chinese prescription of the present invention.The prescription of the present invention is with tarragon and Poria cocos as monarch drug in a prescription, Wen Jing
Hemostasis, clearing and activating the channels and collaterals, the peaceful heart of invigorating the spleen；With windproof, the root of bidentate achyranthes, Ligusticum wallichii and the seed of Chinese dodder as ministerial drug, filling liver kidney, strengthening the bones and muscles, inducing diaphoresis to dispel wind, row of invigorating blood circulation
Gas, controlling nocturnal emission with astringent drugs contracting urine；With the fruit of glossy privet, Radix Angelicae Sinensis, Fructus Corni and matrimony vine as adjutant, tonifying the liver and kidney, inrigorating qi and promoting blood circulation, puckery essence takes off admittedly；With ginger and Radix Glycyrrhizae
For making medicine, appetizing and in, coordinating the drug actions of a prescription；The all medicines of monarch coordinate, collaborative promotion, complement each other, are finally reached effect of kidney-replenishing nourishing kidney-yin,
It is applicable to Patients with Kidney Deficiency Type.
Compared with prior art, the present invention has a following technical advantage:
1, Chinese medicinal formulae of the present invention can significantly alleviate losing weight of rat of suffering from a deficiency of the kidney, and makes heart rate recover to normal level, significantly extends rat of suffering from a deficiency of the kidney
Motion total time and power exhaust the time, increase spleen weight and the chest gland weight of rat of suffering from a deficiency of the kidney, increase the immunity of rat and exercise tolerance, to kidney deficiency rat
Result for the treatment of is notable.
2, compared with the chemotherapeutic agent of Current therapeutic kidney deficiency, Chinese medicinal formulae prescription of the present invention is pure natural medicinal material, and bad reaction is little, secondary work
With low, and Chinese medicinal formulae effect of the present invention is comprehensive, kidney-replenishing nourishing kidney-yin effectively, it is adaptable to treatment kidney deficiency.
3, Chinese medicinal formulae of the present invention also has compatibility science, cure rate is high, be difficult to the advantages such as recurrence.
Detailed description of the invention
It will be understood by those skilled in the art that technology disclosed in following example represents the performance in the practice of the invention that the inventors discovered that good
The technology of effect.But, disclosed specific embodiments can be made many changes, and still obtain same or analogous result, and not
Depart from the spirit and scope of the present invention.
Embodiment 1
The embodiment of the present invention 1 Chinese medicinal formulae is prepared from by the raw material of following parts by weight: tarragon 21 parts, windproof 17 parts, 19 parts of Poria cocos, ox
15 parts of knee, Ligusticum wallichii 16 parts, the seed of Chinese dodder 10 parts, the fruit of glossy privet 9 parts, Radix Angelicae Sinensis 12 parts, Fructus Corni 13 parts, matrimony vine 9 parts, 10 parts of ginger and sweet
Grass 7 parts.
Preparation method is as follows:
S1, weigh each taste raw medicinal material in proportion；
S2, tarragon, windproof, Poria cocos, the root of bidentate achyranthes, Ligusticum wallichii, the seed of Chinese dodder, the fruit of glossy privet, Radix Angelicae Sinensis, Fructus Corni, matrimony vine, ginger and Radix Glycyrrhizae are gone respectively
Impurity, cleans, and dries, is ground into meal；
S3, the ingredients meal mixing prepared by S2, add the distilled water of initial 6 times of weight of medicinal material, soak 14 hours, decoct 2 hours,
Filter and retain filtrate；Add the purified water of initial 8 times of weight of medicinal material, decoct 2 hours, filter and retain filter residue；Merging filtrate, is concentrated into
65 DEG C of relative densities be 1.20 concentrate standby；
S4, ethanol toward the concentration 75% adding 6 times of weight in the filter residue of S3, refluxing extraction 2 times, each 2 hours, filter and retain filtrate,
Merging filtrate, decompression is distilled off ethanol, and it is standby to be concentrated into the concentrate that 65 DEG C of relative densities are 1.20；
S5, the concentrate of S3 and S4 gained being merged, continuing to be concentrated into 65 DEG C of relative densities is the Chinese medical concrete of 1.35, standby；
S5, toward the Chinese medical concrete of S4 gained adds auxiliary material, utilize modern general Chinese medicine preparation technology to make capsule.
Embodiment 2
The embodiment of the present invention 2 Chinese medicinal formulae is prepared from by the raw material of following parts by weight: tarragon 27 parts, windproof 22 parts, 26 parts of Poria cocos, ox
21 parts of knee, Ligusticum wallichii 22 parts, the seed of Chinese dodder 16 parts, the fruit of glossy privet 15 parts, Radix Angelicae Sinensis 16 parts, Fructus Corni 18 parts, matrimony vine 15 parts, 16 parts of ginger and
12 parts of Radix Glycyrrhizae.
Preparation method is with embodiment 1.
Embodiment 3
The embodiment of the present invention 3 Chinese medicinal formulae is prepared from by the raw material of following parts by weight: tarragon 24 parts, windproof 20 parts, 22 parts of Poria cocos, ox
18 parts of knee, Ligusticum wallichii 19 parts, the seed of Chinese dodder 13 parts, the fruit of glossy privet 12 parts, Radix Angelicae Sinensis 14 parts, Fructus Corni 15 parts, matrimony vine 12 parts, 13 parts of ginger and
9 parts of Radix Glycyrrhizae.
Preparation method is with embodiment 1.
Embodiment 4
The embodiment of the present invention 4 Chinese medicinal formulae is prepared from by the raw material of following parts by weight: tarragon 22 parts, windproof 18 parts, 20 parts of Poria cocos, ox
16 parts of knee, Ligusticum wallichii 17 parts, the seed of Chinese dodder 11 parts, the fruit of glossy privet 10 parts, Radix Angelicae Sinensis 13 parts, Fructus Corni 14 parts, matrimony vine 11 parts, 11 parts of ginger and
8 parts of Radix Glycyrrhizae.
Preparation method is with embodiment 1.
Embodiment 5
The embodiment of the present invention 5 Chinese medicinal formulae is prepared from by the raw material of following parts by weight: tarragon 26 parts, windproof 21 parts, 24 parts of Poria cocos, ox
19 parts of knee, Ligusticum wallichii 21 parts, the seed of Chinese dodder 15 parts, the fruit of glossy privet 14 parts, Radix Angelicae Sinensis 15 parts, Fructus Corni 17 parts, matrimony vine 14 parts, 15 parts of ginger and
11 parts of Radix Glycyrrhizae.
Preparation method is with embodiment 1.
The Chinese medicinal formulae of the present invention impact on kidney deficiency rat
1. animal used as test: SPF level SD male rat 80, is provided by Guangdong Province's Experimental Animal Center.
2. Experimental agents: the capsule that embodiment of the present invention 1-5 prepares respectively；Positive control drug is capsule for tonifying kidneys and nourishing brain (Taiji Group Zhe Jiangdong
Pharmaceutical Co. Ltd of side, traditional Chinese medicines quasi-word Z33020888).
3. experimental technique:
After animal used as test is raised 1 week under normal operation, 80 rats are randomly divided into 8 groups, often group 10, be respectively as follows: blank group,
Test A-E group, positive controls, model group, the wherein solution of the capsule preparation that test A-E group gavage respectively prepares to embodiment of the present invention 1-5,
Dosage is 30mg/kg；Positive controls gavage gives the solution of commercially available capsule for tonifying kidneys and nourishing brain preparation, and dosage is 25mg/kg；Blank
Group and the equal gavage of model group to the physiological saline of equivalent, each group gavage every day 1 time, and the 5-9 days, except blank group hypodermic injection physiological saline
Outward, remaining respectively organizes equal hypodermic injection hydrocortisone parenteral solution, and dosage is 25mg/kg body weight.Heart rate and the body weight of each group of rat is detected in the 9th day
Change, the mensuration of action endurance target of going forward side by side, then put to death, measure thymus gland and the weight in wet base of spleen.
4. experimental result
Table 1 Chinese medicinal formulae of the present invention is on the exercise tolerance index of rat of suffering from a deficiency of the kidney and the impact of heart rate
Note: compare with blank group,#P ＜ 0.05,##P ＜ 0.01；Compare with model group,*P ＜ 0.05,**P ＜ 0.01.
Weight gain, spleen weight and the impact of chest gland weight on rat of suffering from a deficiency of the kidney of table 2 Chinese medicinal formulae of the present invention
| Group | Quantity | Dosage (mg/kg) | Weight gain (g) | Spleen weight (mg) | Chest gland weight (mg) |
| Blank group | 10 | - | 30.26±3.47 | 106.72±17.35 | 38.98±6.72 |
| Model group | 10 | - | -8.15±1.56### | 70.34±11.32# | 20.52±4.06## |
| Positive controls | 10 | 25 | 21.45±3.10*** | 99.45±9.27* | 31.12±7.10* |
| A group | 10 | 30 | 18.77±3.24*** | 97.68±9.40* | 37.20±6.35** |
| B group | 10 | 30 | 20.10±2.80*** | 100.20±12.25* | 36.34±6.10** |
| C group | 10 | 30 | 21.56±3.22*** | 103.61±15.76* | 38.45±7.02** |
| D group | 10 | 30 | 19.72±3.63*** | 98.80±10.21* | 35.50±6.51** |
| E group | 10 | 30 | 19.05±2.68*** | 99.63±10.02* | 36.26±6.27** |
Note: compare with blank group,#P ＜ 0.05,##P ＜ 0.01,###P ＜ 0.001；Compare with model group,*P ＜ 0.05,**P ＜ 0.01,***P
＜ 0.001.
From the above results, model group is compared with blank group, and the indices of rat is all remarkably decreased, and modeling success is described；Give this
Chinese medicinal formulae and commercially available capsule for tonifying kidneys and nourishing brain prepared by bright each embodiment are treated, all can notable the motion total time of lengthening model group rat, power
Exhausting the time, and alleviate the losing weight of rat of suffering from a deficiency of the kidney, the rat heart rate that makes to suffer from a deficiency of the kidney recovers to normal level, increases spleen weight and the thymic weight of rat,
Illustrating that Chinese medicinal formulae of the present invention has significant curative effect to kidney deficiency, its result for the treatment of is suitable with positive control drug, and prepare with C group i.e. experimental example 3
Chinese medicinal formulae effect is the most notable.In sum, Chinese medicinal formulae of the present invention can strengthen the exercise tolerance of Patients with Kidney Deficiency Type, and can be by increasing spleen, chest
Gland index, improves the immunity of Patients with Kidney Deficiency Type, effect of performance enriching yin and nourishing kidney, and can improve the appetite of rat of suffering from a deficiency of the kidney, increase food-intake, alleviate
Suffer from a deficiency of the kidney the losing weight of rat.
Owing to describing the present invention by above preferred embodiment, in the spirit and/or scope of the present invention, any replacement for the present invention/
Or combination implement the present invention, will be apparent from for a person skilled in the art, and be included among the present invention.
Claims (6)
1. the Chinese medicinal formulae of the kidney-replenishing nourishing kidney-yin containing tarragon, it is characterised in that described Chinese medicinal formulae is by the raw material system of following parts by weight
For forming:
Tarragon 21-27 part, windproof 17-22 part, Poria cocos 19-26 part, root of bidentate achyranthes 15-21 part, Ligusticum wallichii 16-22 part, seed of Chinese dodder 10-16 part, glossy privet
Sub-9-15 part, Radix Angelicae Sinensis 12-16 part, Fructus Corni 13-18 part, matrimony vine 9-15 part, ginger 10-16 part and Radix Glycyrrhizae 7-12 part.
2. the Chinese medicinal formulae of the kidney-replenishing nourishing kidney-yin containing tarragon as claimed in claim 1, it is characterised in that described Chinese medicinal formulae is by following heavy
The raw material of amount number is prepared from:
Tarragon 21 parts, windproof 17 parts, 19 parts of Poria cocos, the root of bidentate achyranthes 15 parts, Ligusticum wallichii 16 parts, the seed of Chinese dodder 10 parts, the fruit of glossy privet 9 parts, Radix Angelicae Sinensis 12
Part, Fructus Corni 13 parts, matrimony vine 9 parts, 10 parts of ginger and 7 parts of Radix Glycyrrhizae.
3. the Chinese medicinal formulae of the kidney-replenishing nourishing kidney-yin containing tarragon as claimed in claim 1, it is characterised in that described Chinese medicinal formulae is by following heavy
The raw material of amount number is prepared from:
Tarragon 27 parts, windproof 22 parts, 26 parts of Poria cocos, the root of bidentate achyranthes 21 parts, Ligusticum wallichii 22 parts, the seed of Chinese dodder 16 parts, the fruit of glossy privet 15 parts, Radix Angelicae Sinensis 16
Part, Fructus Corni 18 parts, matrimony vine 15 parts, 16 parts of ginger and 12 parts of Radix Glycyrrhizae.
4. the Chinese medicinal formulae of the kidney-replenishing nourishing kidney-yin containing tarragon as claimed in claim 1, it is characterised in that described Chinese medicinal formulae is by following heavy
The raw material of amount number is prepared from:
Tarragon 24 parts, windproof 20 parts, 22 parts of Poria cocos, the root of bidentate achyranthes 18 parts, Ligusticum wallichii 19 parts, the seed of Chinese dodder 13 parts, the fruit of glossy privet 12 parts, Radix Angelicae Sinensis 14
Part, Fructus Corni 15 parts, matrimony vine 12 parts, 13 parts of ginger and 9 parts of Radix Glycyrrhizae.
5. the Chinese medicinal formulae of the kidney-replenishing nourishing kidney-yin containing tarragon as described in claim 1-4 is arbitrary, it is characterised in that described Chinese medicinal formulae is made
Become capsule, tablet, powder, oral liquid, granule or pill.
6. the Chinese medicinal formulae of the kidney-replenishing nourishing kidney-yin containing tarragon as described in claim 1-4 is arbitrary, it is characterised in that the system of described Chinese medicinal formulae
Preparation Method comprises following step:
S1, weigh each taste raw medicinal material in proportion；
S2, tarragon, windproof, Poria cocos, the root of bidentate achyranthes, Ligusticum wallichii, the seed of Chinese dodder, the fruit of glossy privet, Radix Angelicae Sinensis, Fructus Corni, matrimony vine, ginger and Radix Glycyrrhizae are gone respectively
Impurity, cleans, and dries, is ground into meal；
S3, the ingredients meal mixing prepared by S2, add the distilled water of initial 5-8 times of weight of medicinal material, soak 12-20 hour, decoct 2-4
Hour, filter and retain filtrate；Add the purified water of initial 6-9 times of weight of medicinal material, decoct 1-3 hour, filter and retain filter residue；Merge filter
Liquid, is concentrated into the concentrate that 60-70 DEG C of relative density is 1.20-1.25 standby；
S4, ethanol toward concentration 65-75% adding 4-7 times of weight in the filter residue of S3, refluxing extraction 2-3 time, each 2-5 hour, filtration was also
Retaining filtrate, merging filtrate, decompression is distilled off ethanol, and it is standby to be concentrated into the concentrate that 60-70 DEG C of relative density is 1.20-1.25；
S5, the concentrate of S3 and S4 gained is merged, continue to be concentrated into the Chinese medical concrete that 60-70 DEG C of relative density is 1.30-1.35, standby；
S6, toward the Chinese medical concrete of S5 gained adds auxiliary material, utilize modern general Chinese medicine preparation technology to make the finished product preparation of clinical needs.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107184800A (en) * | 2017-05-25 | 2017-09-22 | 成都六然堂益生菌研究所 | A kind of traditional Chinese medicinal ointment of kidney-replenishing nourishing kidney-yin for women takes agent and preparation method thereof |
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| CN1401383A (en) * | 2002-09-13 | 2003-03-12 | 谭翠玉 | Kidney-reinforcing Yang-invigorating pill for treating sexual impotence, and preparing process thereof |
| CN103463357A (en) * | 2013-10-09 | 2013-12-25 | 张玉明 | Medicinal liquor capable of warming and invigorating kidney yang and preparing method thereof |
| CN104547712A (en) * | 2015-01-23 | 2015-04-29 | 崔银方 | Traditional Chinese medicine preparation for treating climacteric syndrome and preparation method of traditional Chinese medicine preparation |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1401383A (en) * | 2002-09-13 | 2003-03-12 | 谭翠玉 | Kidney-reinforcing Yang-invigorating pill for treating sexual impotence, and preparing process thereof |
| CN103463357A (en) * | 2013-10-09 | 2013-12-25 | 张玉明 | Medicinal liquor capable of warming and invigorating kidney yang and preparing method thereof |
| CN104547712A (en) * | 2015-01-23 | 2015-04-29 | 崔银方 | Traditional Chinese medicine preparation for treating climacteric syndrome and preparation method of traditional Chinese medicine preparation |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107184800A (en) * | 2017-05-25 | 2017-09-22 | 成都六然堂益生菌研究所 | A kind of traditional Chinese medicinal ointment of kidney-replenishing nourishing kidney-yin for women takes agent and preparation method thereof |
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