CN105749039A - Traditional Chinese medicine composition for clearing damp and losing weight and preparation and preparation method of traditional Chinese medicine composition - Google Patents

Traditional Chinese medicine composition for clearing damp and losing weight and preparation and preparation method of traditional Chinese medicine composition Download PDF

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CN105749039A
CN105749039A CN201610217721.7A CN201610217721A CN105749039A CN 105749039 A CN105749039 A CN 105749039A CN 201610217721 A CN201610217721 A CN 201610217721A CN 105749039 A CN105749039 A CN 105749039A
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chinese medicine
medicine composition
weight
traditional chinese
composition
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张德龙
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Beijing Yuxintang Biotechnology Co Ltd
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Beijing Yuxintang Biotechnology Co Ltd
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Abstract

The invention provides a traditional Chinese medicine composition for clearing damp and losing weight. The traditional Chinese medicine composition is mainly prepared from the following raw materials: coix seeds, white kidney beans, small red beans, green soya beans, kelp, poria cocos, soybeans, hawthorn, lysimachia christinae hance, Chinese knotweed herbs, medicated leaven, semen cassia and the like. The composition is scientific in compatibility, is capable of removing stasis by inducing diuresis, removing obesity by softening and resolving hard mass, removing intra-intestinal garbage by facilitating the lung, and removing in vivo dross by dissolving phlegm, and is significant and lasting in slimming effect, free of rebound force and free of a side effect. The functions of a human body can be regulated; the traditional Chinese medicine composition can be taken for a long period of time; the fat scale in the body is removed; the body weight is effectively reduced; the traditional Chinese medicine composition is suitable for simple obesity, and also has a good curative effect on eczema and constipation.

Description

A kind of Chinese medicine composition for damp eliminating weight reducing and preparation and preparation method
Technical field
The invention belongs to the field of Chinese medicines, particularly to a kind of Chinese medicine composition for damp eliminating weight reducing and preparation and preparation method.
Background technology
Change along with the raising of people's living standard and living habit, fat people gets more and more, obesity not only affects the attractive in appearance of stature, but also the health of direct harmful to human, increase the danger of cardiovascular disease, affect the function of digestive system, hormonal system, increase the danger that cancer occurs, in addition also result in the variety of problems such as soft tissue of joint damage, reproductive performance decline and mental maladjustment, have become as global public health problem.Slight overweight people can pass through to keep on a diet, adjustment of diet and motion reach the effect of fat-reducing, and severe obesity person then needs to adopt Drug therapy to help to lose weight and fat reducing simultaneously.Current most weight-reducing product is artificial synthetics matter, though its curative effect is good, but easily caused by the symptom such as drowsiness, dizzy, headache, xerostomia, inappetence, gastrointestinal upset, cardiopalmus, anxiety, insomnia, blurred vision, life-time service is also easy to cause the organ functions such as endocrine dysfunction, the infringement heart, liver, kidney, once disable, being also easy to produce weight gain, comparatively speaking, the traditional Chinese medicine capable of reducing weight slim product property of medicine is gentle, side effect is relatively low, safer.CN102552551B discloses a kind of Chinese medicine composition for weight-reducing, Herba Ephedrae, Thallus Laminariae (Thallus Eckloniae), green tea, Radix Et Rhizoma Rhei are prepared from；CN104248669A discloses a kind of Chinese medicine composition with Weight-reducing and lipid-lowering effect, Semen Cassiae, Exocarpium Benincasae, Fructus Crataegi (parched), Fructus Cannabis, Semen Raphani, Pericarpium Citri Reticulatae, Radix Polygoni Multiflori, Radix Et Rhizoma Rhei, Spica Prunellae, Fructus Aurantii are prepared from.But the traditional Chinese medicine capable of reducing weight slim product often fat-reducing effect disclosed in prior art is not ideal enough, or is also easily caused the untoward reaction such as diarrhoea, gastrointestinal upset.
Summary of the invention
In order to solve above-mentioned technical problem, the present invention provides a kind of Chinese medicine composition for damp eliminating weight reducing, is mainly prepared from by the raw material of following weight portion:
The Chinese medicine composition prescription compatibility of the present invention is scientific and reasonable, wherein:
Semen Coicis: for the dry mature kernal of grass Semen Coicis, has effect of promoting diuresis to eliminate damp pathogen, invigorating the spleen to arrest diarrhea, eliminating impediment, evacuation of pus, detoxicating and resolving stagnation of pathogens；
Semen Phaseoli Vulgaris: for the dry mature kernal of leguminous plant scarlet runner bean, has effect of warming the middle warmer and descending qi, profit the intestines and stomach, only singultus, kidney tonifying complement；
Semen Ormosiae Hosiei: for the dry mature seed of leguminous plant Semen Phaseoli or Semen Phaseoli, has effect of inducing diuresis to remove edema, removing toxic substances and promoting pus discharge；
Semen phaseoli radiati: be seed coat be dark green Semen sojae atricolor, has antioxidation, antiinflammatory, maintenance blood vessel elasticity, brain-strengthening and the effect preventing fatty liver from being formed；
Thallus Laminariae (Thallus Eckloniae): for the dry thallus of Laminariaceae plant Thallus Laminariae (Thallus Eckloniae) or Alariaceae plant Thallus Laminariae (Thallus Eckloniae), has effect of hard masses softening and resolving, expectorant, diuretic；
Poria: for the dry sclerotia of On Polyporaceae Poria, has effect of promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming；
Semen Glycines: for the dry seed of Glycine annual herb plant Semen sojae atricolor, has the alleviating distention in middle-JIAO therapeutic method to keep the adverse QI flowing downwards, QI invigorating skin moistening, diuretic relieving distension, controls effect of toxic swelling；
Fructus Crataegi: for the dry mature fruit of rosaceous plant Fructus Pyri Pashiae or Fructus Crataegi, has effect of promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis；
Herba Lysimachiae: the dry herb of Ofthe Primulaceae Lysimachia christinae Hance, have eliminating damp-heat, treating stranguria, detumescence effect；
Herb Polygoni Chinensis: for the dry aerial parts of polygonaceae plant Herb Polygoni Chinensis, has heat-clearing and toxic substances removing, dampness removing disappears effect stagnant, blood-cooling itch-relieving, bright retaining nebula；
Massa Medicata Fermentata: after mixing for the medicine addition flour such as Herba polygoni hydropiperis, Herba Artemisiae Annuae, Semen Armeniacae Amarum or wheat bran, fermented herbal leaven, there is effect of invigorating the spleen and regulating the stomach, promoting digestion and removing stagnation；
Semen Cassiae: for the dry mature seed of leguminous plant Semen Cassiae or little Semen Cassiae, has effect of clearing away heat to improve acuity of vision, loosening bowel to relieve constipation.
The present invention, according to traditional Chinese medical science pharmacology, adopts the Chinese medicine composition that several Chinese crude drugs are prepared from, and the property of medicine is gentle, there is effect of spleen tonifying and fat, Qingre Quyu, diuretic toxin expelling, endocrine regulation, complement each other between each taste Chinese crude drug, work in coordination with promotion, superabundant fats in removing summer-heat body, get rid of vivotoxin, user can effectively lose weight, reducing body fat rate, slimming effect is notable, persistently without bounce-back, and safety non-toxic, period of taking medicine will not produce the side effect such as insomnia, cardiopalmus, diarrhoea, gastrointestinal upset.
As the further improvement of Chinese medicine composition of the present invention, described Chinese medicine composition also includes the raw material that parts by weight are following:
Natrii Sulfas 8-15 Stigma Maydis 5-10 Herba Schizonepetae 3-8 Radix Aristolochiae Fangchi 3-8.
Natrii Sulfas: for Sulfates mineral Natrii Sulfas race Natrii Sulfas, processed refining crystalline solid, has effect of relieving constipation by purgation, moistening for dryness and softening hard mass, detumescence of relieving inflammation or internal heat；
Stigma Maydis: for style and the fresh idea of grass family Zea plant Zea mays, has effect of inducing diuresis to remove edema, suppressing the hyperactive liver function of gallbladder promoting；
Herba Schizonepetae: for the dry aerial parts of labiate Herba Schizonepetae, has effect of induce sweat scattered wind, rash；
Radix Aristolochiae Fangchi: for the root of aristolochiaceae plant Radix Aristolochiae Fangchi, has effect of wind-expelling pain-stopping, clearing away heat and promoting diuresis.
The Chinese medicine composition of the present invention adds Natrii Sulfas, Stigma Maydis, Herba Schizonepetae, four kinds of Chinese crude drugs of Radix Aristolochiae Fangchi, the effect of good clearing heat and expelling damp, strengthening spleen and nourishing blood, repellent antipruritic, anti-inflammation and sterilization can be played, formula compatibility science, can effectively treat various types of eczemas such as acute eczema, subacute eczema and chronic eczema, and this medicine has no side effect without hormone, safety, suitable various people take.
As the further improvement of Chinese medicine composition of the present invention, described Chinese medicine composition also includes the raw material that parts by weight are following:
Semen sojae atricolor 8-15 Semen Sesami 5-10 Folium Nelumbinis 5-10 green tea 5-10.
Semen sojae atricolor: for the black seeds of legume soybean, there is yin nourishing QI invigorating, nourish improving eyesight, solar heat protection of dispeling the wind, promoting blood circulation and detoxication effect；
Semen Sesami: for the dry mature seed of Pedaliaceae (Pedaliaceae) Sesamum plant sesame, has effect that invigorating the liver and kidney, benefiting essence-blood, intestine moistening are dry；
Folium Nelumbinis: for the dried leaves of nymphaeaceae plant lotus, has effect of clearing away summer-heat, sending up the lucid YANG, cooling blood for hemostasis；
Green tea: refer to take the young leaves of Camellia sinensis or bud, not fermented, through completing, shaping, the technique such as drying and the Folium Camelliae sinensis that makes, there is effect of anti-cancer, blood fat reducing and fat-reducing.
The Chinese medicine composition of the present invention adds Semen sojae atricolor, Semen Sesami, Folium Nelumbinis, four kinds of Chinese crude drugs of green tea, plays the effect of loosening bowel to relieve constipation, there is the effect well treating constipation, and health is had no adverse effects, clinical practice safety.
Present invention also offers a kind of oral liquid for damp eliminating weight reducing, ratio of weight and number be that the Chinese medicine composition of 1:1-2:4-6, adjuvant and water form.Chinese medicine composition is fabricated to oral liquid, and drug level height, drug substance stable, mouthfeel are good, taking convenience, be easy to carry.
As the further improvement of above-mentioned oral liquid, described adjuvant includes each composition of following parts by weight:
Methionine 5-8 steviosin 0.5-1 Oleum Cinnamomi 1-2
Butoben sodium salt 0.1-0.3.
Above-mentioned adjuvant can improve Chinese medicine composition dissolubility in oral liquid, is beneficial to absorption of human body.
As the further improvement of above-mentioned oral liquid, described adjuvant also includes each composition of following parts by weight:
Soybean oligo saccharide 2-5 carboxymethyl cellulose 0.5-1.5.
Above two adjuvant can improve the stability of oral liquid, extends the holding time of oral liquid.
The preparation method that present invention also offers the Chinese medicine composition reduced weight for damp eliminating, said method comprising the steps of:
(1) be 26～30MPa, temperature by all raw materials at pressure it is 58～65 DEG C, CO2Carry out carbon dioxide supercritical fluid extraction, combining extraction liquid after extraction 2-3h when flow is 25～35kg/h, filter；
(2) the upper macroporous adsorptive resins of filtrate step (1) prepared, is first 10% ethanol water eluting by concentration, discards eluent；It is 40-70% ethanol water eluting by concentration again, reclaims eluent；
(3) in step (2) gained eluent, add the inulin that concentration is the carboxymethyl starch sodium of 3-5% and 0.5-1%, prepare mixed liquor；
(4) mixed liquor spray drying step (3) prepared, process conditions are: feeding temperature is 70-90 DEG C, and the inlet temperature of spray dryer is 130-150 DEG C, and leaving air temp is 60-80 DEG C, and high-pressure steam pressure is 0.6-0.8MPa.
Prepare Chinese medicine composition to adopt and directly pulverized by raw material, the fried rear filtering and concentrating that added water by raw material, use water or ethanol to carry out the multiple methods such as extraction.The present invention adopt first with carbon dioxide supercritical fluid extraction, again through macroporous resin column eluting, finally spray-dried technique, it is possible to obtain good stability, effective ingredient is high, granule fine and smooth, impurity is few, prevented from caking, have good dispersibility and deliquescent product.
Present invention also offers the another kind of Chinese medicine composition for damp eliminating weight reducing, be mainly prepared from by the raw material of following weight portion:
The present invention provides a kind of Chinese medicine composition for damp eliminating weight reducing, this Chinese medicine composition prescription compatibility science, by diuretic with stasis of dispelling, hard masses softening and resolving with too fat to move, the lung qi dispersing of disappearing with except enteral rubbish, expectorant are with except internal waste matter, slimming effect is notable and persistently without bounce-back, has no side effect, and energy regulating body function, can long-term taking, purged body lactone dirt, effectively lose weight, suitable in simple obesity, treatment eczema and constipation symptom also there is good curative effect simultaneously.
Detailed description of the invention
Embodiment 1
A kind of Chinese medicine composition, said composition is grouped into by the one-tenth of following weight:
The preparation method of described Chinese medicine composition:
Fully soak adding water after all raw material pulverizing, heating and refluxing extraction 2 times, each 2 hours, collect extracting solution concentrate drying, pulverize to obtain fine powder.
Embodiment 2
A kind of Chinese medicine composition, said composition is grouped into by the one-tenth of following weight:
The preparation method of described Chinese medicine composition:
All raw materials are obtained medicine juice by cleaning, soak, decoct, filtering；Gained medicine juice is dried to obtain fine powder through drying process with atomizing.
Embodiment 3
A kind of Chinese medicine composition, said composition is grouped into by the one-tenth of following weight:
The preparation method of described Chinese medicine composition:
(1) be 26MPa, temperature by all raw materials at pressure it is 58 DEG C, CO2Carry out carbon dioxide supercritical fluid extraction, combining extraction liquid after extraction 3h when flow is 25kg/h, filter；
(2) the upper macroporous adsorptive resins of filtrate step (1) prepared, is first 10% ethanol water eluting by concentration, discards eluent；It is 40% ethanol water eluting by concentration again, reclaims eluent；
(3) in step (2) gained eluent add concentration be 3% carboxymethyl starch sodium and 0.5% inulin, prepare mixed liquor；
(4) mixed liquor spray drying step (3) prepared, process conditions are: feeding temperature is 70 DEG C, and the inlet temperature of spray dryer is 130 DEG C, and leaving air temp is 60 DEG C, and high-pressure steam pressure is 0.6MPa.
Embodiment 4
A kind of Chinese medicine composition, said composition is grouped into by the one-tenth of following weight:
Preparation method is with embodiment 1.
Embodiment 5
A kind of Chinese medicine composition, said composition is grouped into by the one-tenth of following weight:
Preparation method is with embodiment 2.
Embodiment 6
A kind of Chinese medicine composition, said composition is grouped into by the one-tenth of following weight:
The preparation method of described Chinese medicine composition:
(1) be 30MPa, temperature by all raw materials at pressure it is 65 DEG C, CO2Carry out carbon dioxide supercritical fluid extraction, combining extraction liquid after extraction 2h when flow is 35kg/h, filter；
(2) the upper macroporous adsorptive resins of filtrate step (1) prepared, is first 10% ethanol water eluting by concentration, discards eluent；It is 70% ethanol water eluting by concentration again, reclaims eluent；
(3) in step (2) gained eluent add concentration be 5% carboxymethyl starch sodium and 1% inulin, prepare mixed liquor；
(4) mixed liquor spray drying step (3) prepared, process conditions are: feeding temperature is 90 DEG C, and the inlet temperature of spray dryer is 150 DEG C, and leaving air temp is 80 DEG C, and high-pressure steam pressure is 0.8MPa.
Embodiment 7
A kind of Chinese medicine composition, said composition is grouped into by the one-tenth of following weight:
Preparation method is with embodiment 1.
Embodiment 8
A kind of Chinese medicine composition, said composition is grouped into by the one-tenth of following weight:
Preparation method is with embodiment 2.
Embodiment 9
A kind of Chinese medicine composition, said composition is grouped into by the one-tenth of following weight:
The preparation method of described Chinese medicine composition:
(1) be 28MPa, temperature by all raw materials at pressure it is 60 DEG C, CO2Carry out carbon dioxide supercritical fluid extraction, combining extraction liquid after extraction 2.5h when flow is 30kg/h, filter；
(2) the upper macroporous adsorptive resins of filtrate step (1) prepared, is first 10% ethanol water eluting by concentration, discards eluent；It is 50% ethanol water eluting by concentration again, reclaims eluent；
(3) in step (2) gained eluent add concentration be 4% carboxymethyl starch sodium and 0.8% inulin, prepare mixed liquor；
(4) mixed liquor spray drying step (3) prepared, process conditions are: feeding temperature is 80 DEG C, and the inlet temperature of spray dryer is 140 DEG C, and leaving air temp is 70 DEG C, and high-pressure steam pressure is 0.7MPa.
Embodiment 10
A kind of Chinese medicine composition, said composition is grouped into by the one-tenth of following weight:
Preparation method is with embodiment 1.
Embodiment 11
A kind of Chinese medicine composition, said composition is grouped into by the one-tenth of following weight:
Preparation method is with embodiment 2.
Embodiment 12
A kind of Chinese medicine composition, said composition is grouped into by the one-tenth of following weight:
Preparation method is with embodiment 3.
Embodiment 13
A kind of oral liquid, this oral liquid is grouped into by the one-tenth of following weight:
Prepared by conventional method.
Embodiment 14
A kind of oral liquid, this oral liquid is grouped into by the one-tenth of following weight:
Prepared by conventional method.
Embodiment 15
A kind of oral liquid, this oral liquid is grouped into by the one-tenth of following weight:
Prepared by conventional method.
Embodiment 16
A kind of oral liquid, this oral liquid is grouped into by the one-tenth of following weight:
Prepared by conventional method.
Embodiment 17
A kind of oral liquid, this oral liquid is grouped into by the one-tenth of following weight:
Prepared by conventional method.
Embodiment 18
A kind of oral liquid, this oral liquid is grouped into by the one-tenth of following weight:
Prepared by conventional method.
Reference examples 1
A kind of oral liquid, this oral liquid is grouped into by the one-tenth of following weight:
Prepared by conventional method.
Reference examples 2
A kind of oral liquid, this oral liquid is grouped into by the one-tenth of following weight:
Prepared by conventional method.
Reference examples 3
A kind of oral liquid, this oral liquid is grouped into by the one-tenth of following weight:
Prepared by conventional method.
Reference examples 4
A kind of oral liquid, this oral liquid is grouped into by the one-tenth of following weight:
Prepared by conventional method.
Reference examples 5
A kind of oral liquid, this oral liquid is grouped into by the one-tenth of following weight:
Prepared by conventional method.
Oral medicine liquid dissolubility test is analyzed
Take the oral liquid of above example 13, reference examples 1 and reference examples 2 respectively, put in medicament dissolution instrument, separately sampled in 1h, 2h, 4h, 6h, 12h, 16h, 24h, detect drug-eluting percentage rate by high performance liquid chromatography, and calculating the cumulative release percentage rate of medicine, result is in Table 1.
Chinese medicine composition dissolution (%) result of the test in table 1 oral liquid
Time (h) Embodiment 13 Reference examples 1 Reference examples 2
0 0 0 0
1 40 25 20
2 72 41 33
4 91 49 45
6 99 52 49
12 100 60 54
16 -- 68 60
24 -- 70 63
From above-mentioned result of the test, the whole dissolution of the oral liquid of embodiment 13 Chinese medicine composition in 12h, and the oral liquid of comparative examples 1-2 still has fractions not have dissolution when 24h, affect the absorption of Chinese medicine composition in human body oral disposition liquid, and then affect therapeutic effect, therefore the mixture adding methionine, steviosin, Oleum Cinnamomi and butoben sodium salt in oral liquid can effectively facilitate the dissolving of Chinese medicine composition, improves the human body absorption to Chinese medicine composition.
Stability of Oral analysis of experiments
1. accelerated test
Example 16, reference examples 3-5 oral liquid, all at temperature 40 DEG C ± 2 DEG C, place 6 months when relative humidity is 75% ± 5%, testing, 1 month period, 2 months, 3 months, 6 the end of month are separately sampled once, the detection character of oral liquid, color and luster, abnormal smells from the patient, main constituent content (labelled amount %) and moisture, it was found that the indices of embodiment 16 has no significant change；And the color of the oral liquid of reference examples 3-5 all deepens, and precipitation occurs.
2. long term test
Example 16, reference examples 3-5 oral liquid, all at temperature 25 DEG C ± 2 DEG C, place 12 months when relative humidity is 60% ± 10%, testing, 0 month period, 3 months, 6 months, 9 months, 12 the end of month are separately sampled once, the detection character of oral liquid, color and luster, main constituent content (labelled amount %) and moisture, it was found that the above-mentioned indices of embodiment 16 has no significant change；And the color of the oral liquid of reference examples 3-5 all substantially deepens, and muddiness and precipitation occur.
From the result of above-mentioned accelerated test and long term test it can be seen that add soybean oligo saccharide and carboxymethyl cellulose oral liquid to be remarkably improved the stability of oral liquid, reducing one of them composition, or change one of them composition, the stability of oral liquid declines.
Fat-reducing effect is analyzed
1. test crowd
360 example experimenters, the age, between 18-70 year, is BMI > 30 (BMI=body weight (Kg)/heights2(m)) Simple Obesity, be randomly divided into test 1-4 group, compare 1 group and comparison 2 groups, often organize 60 people.
2. therapeutic scheme
Test 1 group of Chinese medicine composition taking embodiment 3, test 2 groups of Chinese medicine compositions taking embodiment 6, test 3 groups of Chinese medicine compositions taking embodiment 9, test 4 groups of Chinese medicine compositions taking embodiment 12, above-mentioned four groups of experimenters take 2 months all continuously, every day, sooner or later respectively once each 5g, half an hour ante cibum took；Compareing 1 group and take the CN102552551B Chinese medicine composition announced, every day respectively once, takes 2 months sooner or later continuously；Compareing 2 groups and take the CN104248669A Chinese medicine composition announced, every day respectively once, takes 2 months sooner or later continuously.Whole experimenters normal diet during treating, does not take any other medicine with fat-reducing effect or health product, does not carry out the large amount of exercise physical training with fat-reducing effect yet.
3. efficacy assessment standard
Effective: weight loss more than 20% or weight loss within normal range (BMI is between 18-25), and more than 1 year can be kept；
Effective: weight loss is more than 5%, and can keep more than 3 months；
Invalid: weight loss is less than 5%, or it is heavy or bounce-back to recover substance in 3 months.
4. interpretation of result
According to therapeutic scheme and efficacy assessment standard, testing in 1 group of 60 example experimenter, effective 33 examples, effective 25 examples, total effective rate reaches 96.6%；Testing in 2 group of 60 example experimenter, effective 30 examples, effective 27 examples, total effective rate reaches 95%；Testing in 3 group of 60 example experimenter, effective 36 examples, effective 22 examples, total effective rate reaches 96.6%；Testing in 4 group of 60 example experimenter, effective 25 examples, effective 26 examples, total effective rate is 85%；And above-mentioned four groups of experimenters take off mourning clothes during medication and had outside the phenomenon perspiring increase with the first of Chinese medicine composition week, all without the ill symptoms such as nervous, headache, sleep disorder, anorexia, diarrhoea, body void, visceral organ injury；Compareing in 1 group of 60 example experimenter, effective 12 examples, effective 23 examples, total effective rate is 58.3%；Compareing in 2 group of 60 example experimenter, effective 5 examples, effective 26 examples, total effective rate is 51.7%
5. conclusion
Above-mentioned result of the test shows, Chinese medicine composition weight-reducing of the present invention is evident in efficacy, lasting, hence it is evident that is better than comparison 1 group and the effect of 2 groups of drug administrations of comparison, and does not find toxic and side effects, is suitable for Obesity patient and takes to be used as to lose weight.
Treatment eczema effect analysis
1. test crowd
200 example experimenters, are divided into test 5 groups and test 6 groups.Wherein testing 5 groups is 100 example acute eczema patients, and symptom is: there is a sheet of erythema in affected part, the intensive or little pimple evacuated, and the vesicle that naked eyes difficulty is shown in；Testing 6 groups is 100 example patients with chronic eczema, and symptom is: there are wellability erythema, a small amount of pimple bleb and vesicle in affected part, and incrustation, there is breach at the position bigger at dermatoglyph especially movement degree.
2. therapeutic scheme
The Chinese medicine composition of the oral embodiment of the present invention 6 of whole experimenters, every day 3 times, each 10 grams, takes medicine 7 days continuously.
3. efficacy assessment standard
Cure: eczema all disappears.
Effective: eczema symptom substantially alleviates, major part erythema, pimple, vesicle disappear, and experimenter affected part gargalesthesia alleviates.
Invalid: eczema symptom is without obvious alleviation.
4. interpretation of result
According to therapeutic scheme and efficacy assessment standard, testing in 5 group of 100 example experimenter, 68 examples of fully recovering, effective 32 examples, effective percentage is 100%；Testing in 6 group of 100 example experimenter, 53 examples of fully recovering, effective 44 examples, invalid 3 examples, effective percentage is 97%.
5. conclusion
The above results shows, after in the present invention drug composition adding Natrii Sulfas, Stigma Maydis, Herba Schizonepetae and 4 kinds of Chinese crude drugs of Radix Aristolochiae Fangchi, can effectively treat various types of eczemas such as acute eczema, subacute eczema and chronic eczema, and this medicine is without hormone, takes safety.
Treatment anti-constipation effect analysis
1. test crowd
100 example experimenters, the age, in 14-65 one full year of life, is constipation and continues the patient of more than month, and does not take the medicine of cathartic or other treatment difficult defecation or health product (but can external glycerin or coloclysis assist) before the treatment in one week.
2. therapeutic scheme
The Chinese medicine composition of the oral embodiment of the present invention 9 of whole experimenters, every day respectively once, each 10 grams, takes medicine 15 days sooner or later continuously.
3. efficacy assessment standard
Curing: every 2 days defecations 1 time, just matter is relatively moistened, and defecation is unobstructed, in a short time without recurrence；
Effective: every 3 days defecations 1 time, just matter turns profit, and defecation owes smooth；
Invalid: defecation frequency and just matter all without improving, still need to by cathartic.
4. interpretation of result
According to therapeutic scheme and efficacy assessment standard, in 100 example experimenters, 35 examples of fully recovering, effective 61 examples, effective percentage reaches 96%.
5. conclusion
The above results shows, after adding Semen sojae atricolor, Semen Sesami, Folium Nelumbinis and 4 kinds of Chinese crude drugs of green tea in the present invention, has the effect of loosening bowel to relieve constipation in drug composition, and treatment anti-constipation effect is notable.

Claims (9)

1. the Chinese medicine composition for damp eliminating weight reducing, it is characterised in that described Chinese medicine composition is mainly prepared from by the raw material of following weight portion:
2. the Chinese medicine composition for damp eliminating weight reducing according to claim 1, it is characterised in that described Chinese medicine composition also includes the raw material that parts by weight are following:
Natrii Sulfas 8-15 Stigma Maydis 5-10 Herba Schizonepetae 3-8 Radix Aristolochiae Fangchi 3-8.
3. the Chinese medicine composition for damp eliminating weight reducing according to claim 1, it is characterised in that described Chinese medicine composition also includes the raw material that parts by weight are following:
Semen sojae atricolor 8-15 Semen Sesami 5-10 Folium Nelumbinis 5-10 green tea 5-10.
4. for an oral liquid for damp eliminating weight reducing, by arbitrary described the forming for the Chinese medicine composition of damp eliminating weight reducing, adjuvant and water of claim 1-3, it is characterised in that the ratio of weight and number of described Chinese medicine composition, adjuvant and water is 1:1-2:4-6.
5. oral liquid according to claim 4, it is characterised in that described adjuvant includes each composition of following parts by weight:
Methionine 5-8 steviosin 0.5-1 Oleum Cinnamomi 1-2
Butoben sodium salt 0.1-0.3.
6. oral liquid according to claim 5, it is characterised in that described adjuvant also includes each composition of following parts by weight:
Soybean oligo saccharide 2-5 carboxymethyl cellulose 0.5-1.5.
7. the preparation method according to the arbitrary described Chinese medicine composition for damp eliminating weight reducing of claim 1-3, it is characterised in that said method comprising the steps of:
(1) be 26～30MPa, temperature by all raw materials at pressure it is 58～65 DEG C, CO2Carry out carbon dioxide supercritical fluid extraction, combining extraction liquid after extraction 2-3h when flow is 25～35kg/h, filter；
(2) the upper macroporous adsorptive resins of filtrate step (1) prepared, is first 10% ethanol water eluting by concentration, discards eluent；It is 40-70% ethanol water eluting by concentration again, reclaims eluent；
(3) in step (2) gained eluent, add the inulin that concentration is the carboxymethyl starch sodium of 3-5% and 0.5-1%, prepare mixed liquor；
(4) mixed liquor spray drying step (3) prepared, process conditions are: feeding temperature is 70-90 DEG C, and the inlet temperature of spray dryer is 130-150 DEG C, and leaving air temp is 60-80 DEG C, and high-pressure steam pressure is 0.6-0.8MPa.
8. claim 1-3 arbitrary described Chinese medicine composition application in the medicine that preparation is reduced weight for damp eliminating.
9. the Chinese medicine composition for damp eliminating weight reducing, it is characterised in that described Chinese medicine composition is mainly prepared from by the raw material of following weight portion:
CN201610217721.7A 2016-04-08 2016-04-08 Traditional Chinese medicine composition for clearing damp and losing weight and preparation and preparation method of traditional Chinese medicine composition Pending CN105749039A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106617228A (en) * 2016-09-29 2017-05-10 朱素红 Weight-reducing and recuperating meal and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103007100A (en) * 2013-01-14 2013-04-03 广东一方制药有限公司 Composition with functions of body slimming and waistline reduction and preparation method of composition

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103007100A (en) * 2013-01-14 2013-04-03 广东一方制药有限公司 Composition with functions of body slimming and waistline reduction and preparation method of composition

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106617228A (en) * 2016-09-29 2017-05-10 朱素红 Weight-reducing and recuperating meal and preparation method thereof

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