CN105748959A - Medicine composition for lowering blood pressure, preparation containing same and application - Google Patents
Medicine composition for lowering blood pressure, preparation containing same and application Download PDFInfo
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- CN105748959A CN105748959A CN201610265648.0A CN201610265648A CN105748959A CN 105748959 A CN105748959 A CN 105748959A CN 201610265648 A CN201610265648 A CN 201610265648A CN 105748959 A CN105748959 A CN 105748959A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8988—Gastrodia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention relates to a medicine composition for lowering blood pressure, a preparation containing the same and application.The medicine composition is composed of, by weight, 5-15 parts of rhizoma gastrodiae, 5-15 parts of flos chrysanthemi, 5-15 parts of radix achyranthis bidentatae, 5-15 parts of semen ziziphi spinosae, 5-15 parts of radix stephaniae tetrandrae and 1-5 parts of coptis chinensis.The invention further discloses the preparation containing the composition, and the preparation has the effect of calming the liver and suppressing yang and is suitable for the syndrome of hyperactivity of liver-yang of high blood pressure.
Description
Technical field
The present invention relates to Chinese medicine composition, specifically, relate to the pharmaceutical composition of a kind of blood pressure lowering and containing its preparation and application.
Background technology
Hypertension is one of modal chronic disease, is also the topmost risk factor of cardiovascular and cerebrovascular disease, and apoplexy, myocardial infarction, heart failure and chronic kidney disease are its major complications.Predicting according to World Health Organization (WHO), to the year two thousand twenty, noninfectious will account for the 79% of China's cause of death.Wherein the cardiovascular disease such as hypertension will account for first place.Therefore, prevention and Hypertension have become the focus of society research.Effectively prevention and treatment hypertension are one of significant problems urgently to be resolved hurrily at present.Existing Altace Ramipril is usually Western medicine, has bigger side effect for the liver of human body, kidney etc. and easily causes the uncomfortable reaction such as cough, edema, dizziness.Find a kind of can the medicine of effectively blood pressure lowering and safe without toxic side effect necessary.
Summary of the invention
In order to solve problems of the prior art, it is an object of the invention to provide the pharmaceutical composition of a kind of blood pressure lowering and preparation thereof and application.
Technical solution of the present invention is as follows:
The pharmaceutical composition of a kind of blood pressure lowering, is grouped into by the one-tenth of following weight portion: 5～15 parts of Rhizoma Gastrodiae, Flos Chrysanthemi 5～15 parts, Radix Achyranthis Bidentatae 5～15 parts, Semen Ziziphi Spinosae 5～15 parts, Radix Stephaniae Tetrandrae 5～15 parts and Rhizoma Coptidis 1～5 part.
Preferably, the pharmaceutical composition of described blood pressure lowering, the one-tenth of following weight portion it is grouped into: 8～12 parts of Rhizoma Gastrodiae, Flos Chrysanthemi 8～12 parts, Radix Achyranthis Bidentatae 8～12 parts, Semen Ziziphi Spinosae 8～12 parts, Radix Stephaniae Tetrandrae 8～12 parts and Rhizoma Coptidis 2～4 parts.
It is further preferred that the pharmaceutical composition of described blood pressure lowering, the one-tenth of following weight portion it is grouped into: 10 parts of Rhizoma Gastrodiae, Flos Chrysanthemi 10 parts, Radix Achyranthis Bidentatae 10 parts, Semen Ziziphi Spinosae 10 parts, Radix Stephaniae Tetrandrae 10 parts and Rhizoma Coptidis 3 parts.
Pharmaceutical composition of the present invention can be prepared from by existing conventional method.
The present invention also provides for the pharmaceutical preparation of a kind of blood pressure lowering, described pharmaceutical preparation by above-mentioned blood pressure lowering pharmaceutical composition separately made, or the pharmaceutical composition and pharmaceutically acceptable carrier by above-mentioned blood pressure lowering form.
Described pharmaceutical preparation is pharmaceutically various common formulations, for instance capsule, granule, pill, unguentum, decoction, powder, paster, tablet or oral liquid etc., it is preferred to capsule or granule.
Described pharmaceutically acceptable carrier refers to the pharmaceutical carrier that pharmaceutical field is conventional, one or more in filler, binding agent, disintegrating agent, lubricant, suspending agent, wetting agent, pigment, essence, solvent, surfactant or correctives.
Described filler is selected from starch, sucrose, lactose, mannitol, sorbitol, xylitol, microcrystalline Cellulose or glucose etc.；
Described binding agent is selected from cellulose derivative, alginate, starch, water, dextrin, gelatin or polyvinylpyrrolidone etc.；
Described disintegrating agent is selected from microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose or cross-linking sodium carboxymethyl cellulose；
Described lubricant is selected from stearic acid, Polyethylene Glycol, calcium carbonate, sodium bicarbonate, micropowder silica gel, Pulvis Talci or magnesium stearate；
Described suspending agent is selected from micropowder silica gel, Cera Flava, Cera Flava, cellulose, solid polyethylene glycol；
Described wetting agent is selected from glycerol, Tween 80, vaseline, ethoxy aluminium Oleum Ricini or lecithin；
One or more in mature vinegar, yellow vinegar, yellow wine, ethanol, liquid polyethylene glycol, isopropanol, Tween 80, glycerol, propylene glycol, plant wet goods of described solvent, one or more in soybean oil, Oleum Ricini, Oleum Arachidis hypogaeae semen, mediation wet goods of described vegetable oil.
Described surfactant is smooth selected from dodecylbenzene sodium sulfonate, stearic acid, poloxalkol, fatty acid Pyrusussuriensis or Polysorbate (tween) etc.；
Described correctives is selected from aspartame, Sucralose, essence, steviosin, acesulfame potassium, citric acid or saccharin sodium.
The method that present invention also offers preparation said medicine preparation, the method comprises the following steps: conventionally prepared by formulation method.
Preferably, the preparation method of the method for said medicine preparation comprises the steps:
1) each raw material is taken by formula；
2) Rhizoma Gastrodiae, Rhizoma Coptidis are respectively crushed into fine powder, cross 100 mesh sieves, standby；
3) Flos Chrysanthemi, Radix Achyranthis Bidentatae, Semen Ziziphi Spinosae and Radix Stephaniae Tetrandrae are mixed, the reflux, extract, that adds water 2 times, for the first time with 10 times amount water, for the second time with 8 times amount water, each 1 hour, united extraction liquid, it is concentrated into thick extractum (relative density 1.2-1.3), continue vacuum decompression and be dried to dry extract, pulverize, obtain dry extract；
4) by step 3) gained dry extract and step 1) in Rhizoma Gastrodiae fine powder, Rhizoma Coptidis fine powder mix homogeneously, make soft material with ethanol for binding agent, granulate, make granule or capsule further.
Wherein it is preferred to, described step 3) vacuum that dries of vacuum decompression is-0.06～-0.08Mpa.
Present invention also offers aforementioned pharmaceutical compositions application in preparing Altace Ramipril.
Weight portion of the present invention can be the unit of weights well known in the art such as μ g, mg, g, kg, it is also possible to is its multiple, such as 1/10,1/100,10 times, 100 times etc..
The method have the benefit that
Hypertension, differential diagnosis in tcm many genus excessive rising of liver-YANG.Rhizoma Gastrodiae used by pharmaceutical composition of the present invention has effect of suppressing the hyperactive liver and subsiding YANG, is just accord with the syndrome of the excessive rising of liver-YANG of hypertension.The liver belonging to wood and the heart matches fire, wood is the mother of fire, illness of the mother organ affecting the child one, and the fire of Liver Channel rising is often bothered the mind and seen the disease of vexed insomnia, therefore in side with Semen Ziziphi Spinosae both can nourishing the liver easing the affected liver, again can mind tranquilizing and the heart calming, be monarch drug altogether with Rhizoma Gastrodiae.Flos Chrysanthemi is clear Gan Run gently, both can principal drug assistance Rhizoma Gastrodiae suppressing the hyperactive liver, again can liver heat removing easing the affected liver, for ministerial drug.Actually rushing down its son, the fire of Liver Channel can be healed by letting out heart-fire clearly, certainly shows disrespect on Radix Stephaniae Tetrandrae row water in side, and removing pathogen in the heart heavily fortified point kidney, to help the fire of all medicine liver heat removing warps.Liver is arranged in Jiao, the heat of Rhizoma Coptidis then kind clear middle Jiao.Hypertension incidence is many because of excessive rising of liver-YANG to gas and blood and walk with upper, therefore with Radix Achyranthis Bidentatae conducting blood to flow downwards in side, and Radix Achyranthis Bidentatae also has the merit of diuretic, and the Radix Stephaniae Tetrandrae of ministerial drug can be helped with clear profit liver-fire.Upper three medicines make for assistant altogether.All medicines share, and play nourishing the liver easing the affected liver, suppressing the hyperactive liver and subsiding YANG, the fixed dizzy effect of diuresis altogether, then hypertension must heal.
Especially, Rhizoma Gastrodiae, in preparation process, is become with the flour of Rhizoma Coptidis fine powder to make preparation after being directly mixed into dry extract, reasonably saves its effective ingredient, significantly improve curative effect by preparation of the present invention.
Pharmaceutical composition of the present invention and have effect of suppressing the hyperactive liver and subsiding YANG containing its preparation, is just accord with the syndrome of the excessive rising of liver-YANG of hypertension, is used for treating hypertension especially essential hypertension.
Detailed description of the invention
Following example are used for illustrating the present invention, but are not limited to the scope of the present invention.
Embodiment 1
The pharmaceutical composition of a kind of blood pressure lowering, is grouped into by the one-tenth of following weight portion: 10 kilograms of Rhizoma Gastrodiae, Flos Chrysanthemi 10 kilograms, Radix Achyranthis Bidentatae 10 kilograms, Semen Ziziphi Spinosae 10 kilograms, Radix Stephaniae Tetrandrae 10 kilograms and Rhizoma Coptidis 3 kilograms.
The pharmaceutical preparation (mediodespidine Chinese medicine preparation) of a kind of blood pressure lowering, is made up of aforementioned pharmaceutical compositions.The preparation method of said preparation includes:
1) each raw material is taken by formula；
2) Rhizoma Gastrodiae, Rhizoma Coptidis are respectively crushed into fine powder, cross 100 mesh sieves, standby；
3) Flos Chrysanthemi, Radix Achyranthis Bidentatae, Semen Ziziphi Spinosae and Radix Stephaniae Tetrandrae are mixed, the reflux, extract, that adds water 2 times, for the first time with 10 times amount water, for the second time with 8 times amount water, each 1 hour, united extraction liquid, it is concentrated into thick extractum (relative density 1.2), continuation vacuum decompression dries (vacuum is-0.06～-0.08Mpa) and becomes dry extract, pulverizes, obtains dry extract；
4) by step 3) gained dry extract and step 1) in Rhizoma Gastrodiae fine powder, Rhizoma Coptidis fine powder mix homogeneously, make soft material with 80% ethanol (v/v) for binding agent, granulate with 20 order mesh screens, dry, granulate, it is filled in No. 0 capsule, polishing, packaging.
Embodiment 2
The pharmaceutical composition of a kind of blood pressure lowering, is grouped into by the one-tenth of following weight portion: 5 kilograms of Rhizoma Gastrodiae, Flos Chrysanthemi 5 kilograms, Radix Achyranthis Bidentatae 5 kilograms, Semen Ziziphi Spinosae 5 kilograms, Radix Stephaniae Tetrandrae 5 kilograms and Rhizoma Coptidis 1 kilogram.
The pharmaceutical preparation (mediodespidine Chinese medicine preparation) of a kind of blood pressure lowering, is made up of aforementioned pharmaceutical compositions.The preparation method of said preparation is identical with embodiment 1.
Embodiment 3
The pharmaceutical composition of a kind of blood pressure lowering, is grouped into by the one-tenth of following weight portion: 15 kilograms of Rhizoma Gastrodiae, Flos Chrysanthemi 15 kilograms, Radix Achyranthis Bidentatae 15 kilograms, Semen Ziziphi Spinosae 15 kilograms, Radix Stephaniae Tetrandrae 15 kilograms and Rhizoma Coptidis 5 kilograms.
The pharmaceutical preparation (mediodespidine Chinese medicine preparation) of a kind of blood pressure lowering, is made up of aforementioned pharmaceutical compositions.The preparation method of said preparation is identical with embodiment 1.
Embodiment 4
The pharmaceutical composition of a kind of blood pressure lowering, is grouped into by the one-tenth of following weight portion: 8 kilograms of Rhizoma Gastrodiae, Flos Chrysanthemi 8 kilograms, Radix Achyranthis Bidentatae 8 kilograms, Semen Ziziphi Spinosae 8 kilograms, Radix Stephaniae Tetrandrae 8 kilograms and Rhizoma Coptidis 2 kilograms.
The pharmaceutical preparation (mediodespidine Chinese medicine preparation) of a kind of blood pressure lowering, is made up of aforementioned pharmaceutical compositions.The preparation method of said preparation includes:
1) each raw material is taken by formula；
2) Rhizoma Gastrodiae, Rhizoma Coptidis are respectively crushed into fine powder, cross 100 mesh sieves, standby；
3) Flos Chrysanthemi, Radix Achyranthis Bidentatae, Semen Ziziphi Spinosae and Radix Stephaniae Tetrandrae are mixed, the reflux, extract, that adds water 2 times, for the first time with 10 times amount water, for the second time with 8 times amount water, each 1 hour, united extraction liquid, it is concentrated into thick extractum (relative density 1.3), continuation vacuum decompression dries (vacuum is-0.06～-0.08Mpa) and becomes dry extract, pulverizes, obtains dry extract；
4) by step 3) gained dry extract and step 1) in Rhizoma Gastrodiae fine powder, Rhizoma Coptidis fine powder mix homogeneously, make soft material with 80% ethanol (v/v) for binding agent, granulate with 20 order mesh screens, dry, granulate, make granule.
Embodiment 5
The pharmaceutical composition of a kind of blood pressure lowering, is grouped into by the one-tenth of following weight portion: 12 kilograms of Rhizoma Gastrodiae, Flos Chrysanthemi 12 kilograms, Radix Achyranthis Bidentatae 12 kilograms, Semen Ziziphi Spinosae 12 kilograms, Radix Stephaniae Tetrandrae 12 kilograms and Rhizoma Coptidis 4 kilograms.
The pharmaceutical preparation (mediodespidine Chinese medicine preparation) of a kind of blood pressure lowering, with aforementioned pharmaceutical compositions for active component, is respectively prepared decoction, powder, paster, cream, tincture, tablet, capsule, granule, oral liquid by prior art conventional method.
Experimental example
This experimental example, to 90 primary hypertension patients, is randomly divided into 3 groups and carries out contrast experiment.Take embodiment 1-3 gained preparation, every day twice respectively, each 5, after continuing 4 weeks, be assessed as the standard of curative effect evaluation with hypertension in " the medicine for cardiovascular system guideline of clinical investigations draft " of Ministry of Public Health regulation:
Effective: diastolic pressure (DBP) decline >=10mmHg is also down to normal, or DBP decline >=20mmHg；
Effective: DBP decline≤10mmHg but be reduced to normal, or DBP declines 10～20mmHg, or shrinks pressure (SBP) decline >=30mmHg；
Invalid: not up to above-mentioned standard.
Three groups of comparitive study after table 1 treatment
Note: embodiment 2 and embodiment 3 contrast with embodiment 1 respectively, its P < 0.05.
In sum, the total effective rate of pharmaceutical composition of the present invention is more than 63%, and wherein, consumption part proportioning of embodiment 1 is optimal choice.
Although, above the present invention is described in detail with a general description of the specific embodiments, but on basis of the present invention, it is possible to it is made some modifications or improvements, and this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to the scope of protection of present invention.
Claims (9)
1. the pharmaceutical composition of a blood pressure lowering, it is characterised in that be grouped into by the one-tenth of following weight portion: 5～15 parts of Rhizoma Gastrodiae, Flos Chrysanthemi 5～15 parts, Radix Achyranthis Bidentatae 5～15 parts, Semen Ziziphi Spinosae 5～15 parts, Radix Stephaniae Tetrandrae 5～15 parts and Rhizoma Coptidis 1～5 part.
2. pharmaceutical composition according to claim 1, it is characterised in that be grouped into by the one-tenth of following weight portion: 8～12 parts of Rhizoma Gastrodiae, Flos Chrysanthemi 8～12 parts, Radix Achyranthis Bidentatae 8～12 parts, Semen Ziziphi Spinosae 8～12 parts, Radix Stephaniae Tetrandrae 8～12 parts and Rhizoma Coptidis 2～4 parts.
3. pharmaceutical composition according to claim 1, it is characterised in that be grouped into by the one-tenth of following weight portion: 10 parts of Rhizoma Gastrodiae, Flos Chrysanthemi 10 parts, Radix Achyranthis Bidentatae 10 parts, Semen Ziziphi Spinosae 10 parts, Radix Stephaniae Tetrandrae 10 parts and Rhizoma Coptidis 3 parts.
4. the pharmaceutical preparation of a blood pressure lowering, it is characterised in that described pharmaceutical preparation pharmaceutical composition described in any one of claim 1-3 is separately made, or pharmaceutical composition and the pharmaceutically acceptable carrier described in any one of claim 1-3 form.
5. pharmaceutical preparation according to claim 4, it is characterised in that described pharmaceutical preparation is capsule, granule, pill, unguentum, decoction, powder, paster, tablet or oral liquid, it is preferred to capsule or granule.
6. the preparation method of pharmaceutical preparation described in claim 4 or 5, it is characterised in that comprise the steps:
1) each raw material is taken by formula；
2) Rhizoma Gastrodiae, Rhizoma Coptidis are respectively crushed into fine powder, cross 100 mesh sieves, standby；
3) Flos Chrysanthemi, Radix Achyranthis Bidentatae, Semen Ziziphi Spinosae and Radix Stephaniae Tetrandrae are mixed, the reflux, extract, that adds water 2 times, for the first time with 10 times amount water, for the second time with 8 times amount water, each 1 hour, united extraction liquid, it is concentrated into thick extractum, continue vacuum decompression and be dried to dry extract, pulverize, obtain dry extract；
4) by step 3) gained dry extract and step 1) in Rhizoma Gastrodiae fine powder, Rhizoma Coptidis fine powder mix homogeneously, make soft material with ethanol for binding agent, granulate, make granule or capsule further.
7. preparation method according to claim 6, it is characterised in that step 3) vacuum that dries of described vacuum decompression is-0.06～-0.08Mpa.
8. preparation method according to claim 6, it is characterised in that step 4) described binding agent is 80% ethanol.
9. claim 1-3 arbitrary described pharmaceutical composition application in preparing Altace Ramipril.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610265648.0A CN105748959B (en) | 2016-04-26 | 2016-04-26 | Pharmaceutical composition for reducing blood pressure, preparation containing pharmaceutical composition and application of pharmaceutical composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610265648.0A CN105748959B (en) | 2016-04-26 | 2016-04-26 | Pharmaceutical composition for reducing blood pressure, preparation containing pharmaceutical composition and application of pharmaceutical composition |
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| CN105748959A true CN105748959A (en) | 2016-07-13 |
| CN105748959B CN105748959B (en) | 2020-06-23 |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103479971A (en) * | 2013-09-27 | 2014-01-01 | 张锦晔 | Chinese medicine preparation for curing hyperactivity of liver-yang |
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2016
- 2016-04-26 CN CN201610265648.0A patent/CN105748959B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103479971A (en) * | 2013-09-27 | 2014-01-01 | 张锦晔 | Chinese medicine preparation for curing hyperactivity of liver-yang |
Non-Patent Citations (1)
| Title |
|---|
| 陈新宇等: "养肝清肝法对实验性高血压大鼠降压效果及其对左心室肥厚等的影响", 《中国中医急症》 * |
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