CN102846786A - Medicinal preparation for treating hypertension and preparation method thereof - Google Patents
Medicinal preparation for treating hypertension and preparation method thereof Download PDFInfo
- Publication number
- CN102846786A CN102846786A CN 201210360243 CN201210360243A CN102846786A CN 102846786 A CN102846786 A CN 102846786A CN 201210360243 CN201210360243 CN 201210360243 CN 201210360243 A CN201210360243 A CN 201210360243A CN 102846786 A CN102846786 A CN 102846786A
- Authority
- CN
- China
- Prior art keywords
- preparation
- parts
- herba
- lupuli
- flos
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
The invention relates to a medicinal preparation for treating hypertension and a preparation method thereof. The medicinal preparation comprises radix berberidis, herba siegesbeckiae, flos lupuli, herba pyrolae, fructus phyllanthi, ramulus uncariae cum uncis and tabasheer; and is prepared into pharmaceutically acceptable dosage forms such as tablet, granule or capsule according to specific process. The medicinal preparation has effects in clearing away heat and calming liver, invigorating kidney and promoting body fluid production; and has significant treatment effect on hypertension.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of hypertensive pharmaceutical preparation and preparation method thereof for the treatment of.
Background technology
Hypertension is to increase clinical syndrome as main manifestations take systemic arterial pressure, it is modal cardiovascular disease, be divided into two kinds of secondary hypertension and essential hypertensions, most hypertension pathogenies are not clear, be called essential hypertension, clinical manifestation is not for to take in the situation of antihypertensive drug, systolic pressure 〉=140mmHg and (or) diastolic pressure 〉=90mmHg.
Essential hypertension belongs to the category of the traditional Chinese medical science " dizzy ", " headache ", and " the Plain Questions the most pure virginity will be discussed greatly " said: " all wind trembling and dizziness all belong to liver "." bier sea opinion " said: " deficiency of marrow-reservoir, vertigo and tinnitus then, shin dizziness." Chinese medicine thinks, hypertension is because of feelings will internal injury, eating and drinking without temperance, overstrain damage, or asthenia, deficiency of the kidney etc. cause giving birth in internal organs imbalance between YIN and YANG, the wind-fire, the expectorant stasis of blood is handed over resistance with age, QI and blood contrary disorderly due to.Modern scholar thinks essential hypertension take deficiency syndrome as main, and sick position is mainly at the heart, relevant with Liver and kidney.Wang Shi thinks that dizzy morbidity is relevant with silt, and blood stasis has substantial connection with excessive rising of liver-YANG, stagnation of phlegm-damp in middle-JIAO, deficiency of kidney-essence, deficiency of qi and blood, and the dizzy feelings will that mostly is is uncomfortable, is worried angry, and excessive rising of liver-YANG is disturbed in the head; Body constitution is fat, the excessive phlegm that wets, or the rich sweet food of monophagia more, and spleen fortune is not normal, and wet the Sheng made expectorant, stagnation of turbid phlegm in middle-JIAO, upper illiteracy is positive clearly; Weakness due to chronic disease or lose blood after, deficiency of both the heart and spleen, insufficiency of vital energy and blood can not be gone up flourishly in the head, or deficiency of kidney-essence, deficiency of marrow-reservoir, brain lose and moisten fosterly, all easily cause dizzy.
At present, western medical treatment hypertension mainly contains 6 large classes, be diuretic, beta-blocker, calcium antagonist, angiotensin converting enzyme inhibitor, Angiotensin Ⅱ receptor antagonist and adrenergic blocking agent, be the main antihypertensive drugs of clinical practice, but it has blood pressure after taking and easily rebounds, fluctuates and the characteristics such as side effect is large.And the Chinese medicine hypertension can effectively be regulated the function balance between each system of body from integrally-regulated, treatment must aim at the pathogenesis of disease, and hypotensive effect is gentle, and effect is better, and side effect is less.Therefore, development has the function that suppressing the hyperactive liver to relieve the wind syndrome, blood circulation promoting and blood stasis dispelling reduce phlegm, and antihypertensive effect is obvious, side effect is little, is fit to long-term taking, and safe and reliable Chinese medicinal composition preparation has good economic implications and social meaning.
Summary of the invention
The object of the present invention is to provide a kind of hypertensive pharmaceutical preparation for the treatment of, it has, and heat-clearing and toxic substances removing, the kidney invigorating promote the production of body fluid, the effect of suppressing the hyperactive liver to relieve the wind syndrome, phlegm reduction of blood circulation promoting, wind-damp dispelling.
Technical scheme of the present invention is as follows: a kind ofly treat hypertensive pharmaceutical preparation and preparation method thereof, it is characterized in that described compositions made by the raw material of following weight portion:
Radix Berberidis 5 ~ 10 10 ~ 15 parts of Fen, Herba Siegesbeckiaes, 5 ~ 10 parts of Flos lupuli (Flos Humuli Lupuli)s, 5 ~ 10 parts of Herba Pyrolaes, 10 ~ 15 parts of Fructus Phyllanthis, 10 ~ 15 parts of Ramulus Uncariae Cum Uncis, 3 ~ 5 parts of Concretio silicea Bambusae seu schizostachyis.
Described preparation is tablet, capsule, granule, pill, oral liquid formulations, drop pill.
The preparation method of the hypertensive pharmaceutical preparation of described treatment may further comprise the steps:
(1) each drug component carries out weighing by weight, and Herba Pyrolae, Ramulus Uncariae Cum Uncis, Concretio silicea Bambusae seu schizostachyi three flavor medical materials are decocted with water 2-4 time, filters, and collecting decoction is concentrated into the clear paste that relative density is 1.20-1.28, and is for subsequent use;
(2) Radix Berberidis, Herba Siegesbeckiae, Flos lupuli (Flos Humuli Lupuli), Fructus Phyllanthi four Chinese medicine material are added 5-8 and doubly measure the 65-95% alcohol reflux 2-4 time, each 1-2.5 hour, filter, merging filtrate is concentrated into the extractum that relative density is 1.22-1.30, and is for subsequent use;
(3) merge above-mentioned the water extracted immersing paste and alcohol-extracted extract, drying under reduced pressure gets dry extract, is ground into fine powder, adds suitable adjuvant, makes suitable dosage form, and get final product.
Pharmaceutical composition of the present invention is for essential hypertension due to excessive rising of liver-YANG, the phlegm-damp resistance network and the prescription of making laws, prescription promotes the production of body fluid as rule for the treatment of take suppressing the hyperactive liver to relieve the wind syndrome, phlegm reduction of blood circulation promoting, the kidney invigorating, take Ramulus Uncariae Cum Uncis as monarch drug, get its heat clearing away suppressing the hyperactive liver Herba Siegesbeckiae, Radix Berberidis is minister, gets its dispelling wind and removing obstruction in the collateral, heat clearing and damp drying, gets Flos lupuli (Flos Humuli Lupuli) stomach invigorating diuresis, get Herba Pyrolae, the Concretio silicea Bambusae seu schizostachyi expelling wind and removing dampness reduces phlegm, the assistant with the Fructus Phyllanthi secretion replenishing and throat moistening.We also make pharmaceutically acceptable dosage form according to the physicochemical property of effective ingredient according to special process, have the characteristics such as bioavailability is high, absorption is fast, obvious, the easy processing of curative effect.
The specific embodiment:
Further specify the present invention below in conjunction with the specific embodiment, but the scope of protection of present invention is not limited to following embodiment.
One, preparation example:
Embodiment 1: the preparation of pharmaceutical preparation of the present invention:
Prescription proportioning: Radix Berberidis 390g, Herba Siegesbeckiae 390g, Flos lupuli (Flos Humuli Lupuli) 196g, Herba Pyrolae 390g, Fructus Phyllanthi 590g, Ramulus Uncariae Cum Uncis 590g, Concretio silicea Bambusae seu schizostachyi 196g.
Method for making: (1) adds 6 times of water gagings with Herba Pyrolae, Ramulus Uncariae Cum Uncis, Concretio silicea Bambusae seu schizostachyi 3 flavor medical materials, decocts 3 times, and filtration, collecting decoction, being concentrated into relative density is 1.25(60 ℃ of survey) clear paste, for subsequent use;
(2) Radix Berberidis, Herba Siegesbeckiae, Flos lupuli (Flos Humuli Lupuli), Fructus Phyllanthi 4 flavor medical materials are added 8 times of amount 70% alcohol reflux 2 times, each 1.5 hours, filter, merging filtrate, being concentrated into relative density was 1.30(60 ℃ of survey) extractum, for subsequent use;
(3) merge above-mentioned the water extracted immersing paste and alcohol-extracted extract, drying under reduced pressure gets dry extract, is ground into fine powder, adds right amount of auxiliary materials, and mixing is granulated, and sieves, and drying is made 1000g, packing, the pharmaceutical preparation that namely gets granule dosage form of the present invention.
Embodiment 2: the preparation of pharmaceutical preparation of the present invention:
Prescription proportioning: Radix Berberidis 333g, Herba Siegesbeckiae 700g, Flos lupuli (Flos Humuli Lupuli) 417g, Herba Pyrolae 333g, Fructus Phyllanthi 500g, Ramulus Uncariae Cum Uncis 417g, Concretio silicea Bambusae seu schizostachyi 125g.
Method for making: the present embodiment preparation technology is with embodiment 1.
Embodiment 3: the preparation of pharmaceutical preparation of the present invention:
Prescription proportioning: Radix Berberidis 286g, Herba Siegesbeckiae 573g, Flos lupuli (Flos Humuli Lupuli) 286g, Herba Pyrolae 286g, Fructus Phyllanthi 573g, Ramulus Uncariae Cum Uncis 573g, Concretio silicea Bambusae seu schizostachyi 172g.
Method for making: the present embodiment preparation technology is with embodiment 1.
Embodiment 4: the preparation of pharmaceutical preparation of the present invention:
Prescription proportioning: Radix Berberidis 377g, Herba Siegesbeckiae 565g, Flos lupuli (Flos Humuli Lupuli) 301g, Herba Pyrolae 377g, Fructus Phyllanthi 377g, Ramulus Uncariae Cum Uncis 565g, Concretio silicea Bambusae seu schizostachyi 188g.
Method for making: the present embodiment preparation technology is with embodiment 1.
Embodiment 5: the preparation of pharmaceutical preparation of the present invention:
Prescription proportioning: Radix Berberidis 262g, Herba Siegesbeckiae 524g, Flos lupuli (Flos Humuli Lupuli) 393g, Herba Pyrolae 305g, Fructus Phyllanthi 567g, Ramulus Uncariae Cum Uncis 524g, Concretio silicea Bambusae seu schizostachyi 175g.
Method for making: the present embodiment preparation technology is with embodiment 1.
Embodiment 6: the preparation of pharmaceutical preparation of the present invention:
Prescription proportioning: Radix Berberidis 279g, Herba Siegesbeckiae 558g, Flos lupuli (Flos Humuli Lupuli) 279g, Herba Pyrolae 359g, Fructus Phyllanthi 558g, Ramulus Uncariae Cum Uncis 558g, Concretio silicea Bambusae seu schizostachyi 160g.
Method for making: (1) adds 8 times of water gagings with Herba Pyrolae, Ramulus Uncariae Cum Uncis, Concretio silicea Bambusae seu schizostachyi 3 flavor medical materials, decocts 4 times, and filtration, collecting decoction, being concentrated into relative density is 1.20(60 ℃ of survey) clear paste, for subsequent use;
(2) Radix Berberidis, Herba Siegesbeckiae, Flos lupuli (Flos Humuli Lupuli), Fructus Phyllanthi 4 flavor medical materials are added 5 times of amount 65% alcohol reflux 3 times, each 1 hour, filter, merging filtrate, being concentrated into relative density was 1.22(60 ℃ of survey) extractum, for subsequent use;
(3) merge above-mentioned the water extracted immersing paste and alcohol-extracted extract, drying under reduced pressure gets dry extract, is ground into fine powder, adds right amount of auxiliary materials, and mixing is granulated, and sieves, and with the further tabletting of the granule that makes, drying is made 1000, the pharmaceutical preparation that namely gets Tabules of the present invention.
Embodiment 7: the preparation of pharmaceutical preparation of the present invention:
Prescription proportioning: Radix Berberidis 377g, Herba Siegesbeckiae 452g, Flos lupuli (Flos Humuli Lupuli) 377g, Herba Pyrolae 301g, Fructus Phyllanthi 565g, Ramulus Uncariae Cum Uncis 490g, Concretio silicea Bambusae seu schizostachyi 188g.
Method for making: (1) adds 5 times of water gagings with Herba Pyrolae, Ramulus Uncariae Cum Uncis, Concretio silicea Bambusae seu schizostachyi 3 flavor medical materials, decocts 2 times, and filtration, collecting decoction, being concentrated into relative density is 1.23(60 ℃ of survey) clear paste, for subsequent use;
(2) Radix Berberidis, Herba Siegesbeckiae, Flos lupuli (Flos Humuli Lupuli), Fructus Phyllanthi 4 flavor medical materials are added 6 times of amount 65% alcohol reflux 4 times, each 2.5 hours, filter, merging filtrate, being concentrated into relative density was 1.26(60 ℃ of survey) extractum, for subsequent use;
(3) merge above-mentioned the water extracted immersing paste and alcohol-extracted extract, drying under reduced pressure gets dry extract, is ground into fine powder, adds right amount of auxiliary materials, and mixing is granulated, and sieves, and the granule that makes is incapsulated shell, makes 1000, the pharmaceutical preparation that namely gets capsule formulation of the present invention.
Two, test example:
1, testing data:
Observe case 246 examples, 30 ~ 40 years old age, 50 examples, 40 ~ 50 years old 86 example, 110 examples more than 50 years old, course of disease 1-15, patient's blood pressure 150 ~ 190mmHg/95 before the treatment ~ 105mmHg.
2, diagnostic criteria:
With reference to " principle is known in the new Chinese medicine clinical research " (trial version in 2002), light-duty have play bitter taste in slight headache, morning, mouthful little do, slight insomnia, slightly breathe hard after uncomfortable in chest, the activity; Medium-sized headache can be born, the few Tianjin of bitter taste, xerostomia, the time see insomnia, uncomfortable in chest obviously, activity is not also breathed hard; Heavy headache unbearably, top-heavy, bitter taste is puckery, xerostomia is often drunk water, can not fall asleep, uncomfortable in chest as stop up, breathe hard heavier.
3, Therapeutic Method:
Oral medicinal tablet of the present invention, every day 3 times, each 2,30 days is a course for the treatment of, light-duty 1 course for the treatment of, medium-sized 2 courses for the treatment of, heavy 3 courses for the treatment of.
4, efficacy assessment standard:
Produce effects: 1. more than the diastolic pressure decline 10mmHg, and reach normal range; Though 2. diastolic pressure is not down to normally, descended 20mmHg or more than.
Effectively: 1. diastolic pressure descends not as good as 10mmHg, and has reached normal range; 2. diastolic pressure is treated front decline 10 ~ 19mmHg, but does not reach normal range; 3. systolic pressure is treated more than the front decline 30mmHg.Must possess wherein 1.
Invalid: as not reach above standard person.
5, therapeutic outcome: see Table 1:
Table 1:246 example is taken the hypertensive medicinal tablet curative effect for the treatment of of the present invention
Clinical test results shows clinical produce effects 183 examples, obvious effective rate 74.4%; Effective 61 examples, effective percentage 24.8%; Invalid 2 examples, inefficiency 0.8%.
Claims (3)
1. treatment hypertensive pharmaceutical preparation and preparation method thereof is characterized in that described compositions made by the raw material of following weight portion:
Radix Berberidis 5 ~ 10 10 ~ 15 parts of Fen, Herba Siegesbeckiaes, 5 ~ 10 parts of Flos lupuli (Flos Humuli Lupuli)s, 5 ~ 10 parts of Herba Pyrolaes, 10 ~ 15 parts of Fructus Phyllanthis, 10 ~ 15 parts of Ramulus Uncariae Cum Uncis, 3 ~ 5 parts of Concretio silicea Bambusae seu schizostachyis.
2. the hypertensive pharmaceutical preparation for the treatment of according to claim 1 is characterized in that described preparation is tablet, capsule, granule, pill, oral liquid formulations, drop pill.
3. the preparation method of the hypertensive pharmaceutical preparation for the treatment of according to claim 2 may further comprise the steps:
(1) each drug component carries out weighing by weight, and Herba Pyrolae, Ramulus Uncariae Cum Uncis, Concretio silicea Bambusae seu schizostachyi three flavor medical materials are decocted with water 2 ~ 4 times, filters, and collecting decoction is concentrated into relative density and is 1.20 ~ 1.28 clear paste, and is for subsequent use;
(2) Radix Berberidis, Herba Siegesbeckiae, Flos lupuli (Flos Humuli Lupuli), Fructus Phyllanthi four Chinese medicine material are added 5 ~ 8 times of amount 65 ~ 95% alcohol reflux 2 ~ 4 times, each 1 ~ 2.5 hour, filter, merging filtrate is concentrated into the extractum that relative density is 1.22-1.30, and is for subsequent use;
(3) merge above-mentioned the water extracted immersing paste and alcohol-extracted extract, drying under reduced pressure gets dry extract, is ground into fine powder, adds suitable adjuvant, makes suitable dosage form, and get final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210360243 CN102846786A (en) | 2012-09-25 | 2012-09-25 | Medicinal preparation for treating hypertension and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210360243 CN102846786A (en) | 2012-09-25 | 2012-09-25 | Medicinal preparation for treating hypertension and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102846786A true CN102846786A (en) | 2013-01-02 |
Family
ID=47394031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201210360243 Pending CN102846786A (en) | 2012-09-25 | 2012-09-25 | Medicinal preparation for treating hypertension and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102846786A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103599368A (en) * | 2013-11-05 | 2014-02-26 | 刘京伟 | Traditional Chinese medicinal preparation for treating menopause hypertension |
| CN103908588A (en) * | 2014-03-13 | 2014-07-09 | 青岛百瑞吉生物工程有限公司 | Traditional Chinese medicine preparation used for treating hypertension, and preparation method thereof |
| CN105194143A (en) * | 2015-09-16 | 2015-12-30 | 淄博齐鼎立专利信息咨询有限公司 | Medicine preparation for treating hypertension |
-
2012
- 2012-09-25 CN CN 201210360243 patent/CN102846786A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103599368A (en) * | 2013-11-05 | 2014-02-26 | 刘京伟 | Traditional Chinese medicinal preparation for treating menopause hypertension |
| CN103599368B (en) * | 2013-11-05 | 2016-02-17 | 刘京伟 | A kind of Chinese medicine preparation for the treatment of climacteric hypertension |
| CN103908588A (en) * | 2014-03-13 | 2014-07-09 | 青岛百瑞吉生物工程有限公司 | Traditional Chinese medicine preparation used for treating hypertension, and preparation method thereof |
| CN105194143A (en) * | 2015-09-16 | 2015-12-30 | 淄博齐鼎立专利信息咨询有限公司 | Medicine preparation for treating hypertension |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101254272A (en) | Promoting coronary circulation and embolism resistance medicament | |
| KR20130014766A (en) | Oriental medicine composition for curing rhinitis in children and manufacturing method thereof | |
| CN105250821B (en) | A kind of compound Chinese medicinal preparation and preparation method thereof for treating ulcerative colitis | |
| CN102846786A (en) | Medicinal preparation for treating hypertension and preparation method thereof | |
| CN102940730A (en) | Traditional Chinese medicine for treating hypertension | |
| CN104383257A (en) | Chinese medicinal preparation for treating xerophthalmia due to liver depression and deficiency of yin | |
| CN101411851B (en) | Chinese medicinal composition for preventing and treating hyperlipemia symptom and atherosclerosis | |
| CN103202956A (en) | Antihypertensive life-preserving health-care medicinal liquor | |
| CN102641357B (en) | Medicament for treating hypertension and preparation method thereof | |
| KR20120086947A (en) | Oriental medicine composition for curing rhinitis in children and manufacturing method thereof | |
| CN105833043A (en) | Application of traditional Chinese medicine composition in preparation of medicine for treating primary hypertension | |
| CN105194355A (en) | Traditional Chinese medicine preparation for treating primary hypertension | |
| CN105535587A (en) | Traditional Chinese medicinal preparation for treating heart and kidney disharmony type palpitation and insomnia and preparation method of traditional Chinese medicinal preparation | |
| CN104984097A (en) | Chinese herba preparation for treating primary hypertension and application thereof | |
| CN107913315A (en) | A kind of Chinese medicine composition for treating refractory hypertension and preparation method thereof | |
| CN114848724B (en) | Traditional Chinese medicine composition for treating migraine and preparation method thereof | |
| CN103845467B (en) | A kind ofly be used for the treatment of medicine of the vascular hypertension of liver-yang hyperactivity of suffering from a deficiency of the kidney and preparation method thereof | |
| CN103860911B (en) | A kind of pharmaceutical composition treating chronic renal failure and preparation method and purposes | |
| CN102727672B (en) | A kind of Chinese medicine composition for the treatment of hypertensive nephropathy and preparation method thereof | |
| CN102846863A (en) | Traditional Chinese medicine preparation for treating hypertension and preparation method thereof | |
| CN102462757B (en) | Traditional Chinese medicine composition for reducing blood pressure and solid preparation for reducing blood pressure through lavipeditum | |
| CN105362703A (en) | Traditional Chinese medicine composition for treating primary hypertension and preparation method thereof | |
| CN106389999B (en) | Traditional Chinese medicine composition for relieving drunkenness and application thereof | |
| CN105250749A (en) | Traditional Chinese medicine for treating thyroid adenoma and preparation method thereof | |
| CN104825756A (en) | Traditional Chinese medicine composition for treating chronic renal failure |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20130102 |