CN105748901A - 一种保健饮料配方及其制备方法 - Google Patents
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Abstract
本发明公开一种保健饮料配方及其制备方法,包括以下重量份的原料药:菊花10~50份,青葙子10~20份,麦冬10~20份,酸枣仁10~20份,密蒙花10~20份,决明子10~20份,茯苓10~20份,白扁豆10~20份,龙胆草10~20份,陈皮10~20份,甘草10~20份,天花粉10~20份,栀子10~20份,佛手10~20份,地骨皮10~20份,益母草10~20份,谷精草10~20份,玫瑰茄10~20份,夏枯草10~20份,合欢花10~20份。本发明针对都市上班族普遍使用电脑办公久视,烟酒无度,夜生活不节制、熬夜、过度用眼总得不到缓解等伤害肝脏的行为,本发明滋补肝肾、益阴养血、补虚益精气,祛风明目,滋补肝肾的功效,针对性更强。
Description
技术领域
本发明涉及一种保健饮料配方及其制备方法,属于保健饮料技术领域。
背景技术
现代都市上班族普遍使用电脑办公,烟酒无度,夜生活不节制,熬夜,这些都直接伤害了肝气。久视以及辐射,为电脑一族的眼睛健康埋下了隐患。这类人需要注意用眼,护肝养血,缓解疲劳。
现在市面上各种保健品、药品泛滥,但大多数徒有其表,大张旗鼓的虚假宣传,很可能没有任何保健功能,但造成人身体的巨大伤害,因此,寻找健康有效的保健品具有很现实的重要意义。中药保健品具有无毒、能被生物体完全吸收的优点,是我们研究的主要方向。现代都市上班族普遍使用电脑办公久视,烟酒无度,夜生活不节制、熬夜等伤害肝脏的行为,双眼受到血的给养才能视物,而过度用眼,会使肝血亏虚,使双目得不到营养的供给,从而出现眼干涩、看东西模糊、夜盲等。另外,长期久坐用眼,除双目供血不足外,颈椎、腰椎也会产生劳损,总得不到缓解,也会对肝脏造成损害。如果单纯靠药物治疗恐怕很难坚持,胡乱使用眼药水更会使眼睛受损伤,导致各种眼病或失明的危险,且服用中药比较麻烦,口感不佳,不宜长期服用,效果也不一定理想,这就需要一种疗效好针对性强的保健品。
发明内容
为克服上述不足,本发明目的提供一种保健饮料配方及其制备方法。
本发明的方案如下:本发明一种保健饮料配方及其制备方法,其所述保健饮料配方中可以包括以下重量份的原料药:菊花10~50份,青葙子10~20份,麦冬10~20份,酸枣仁10~20份,密蒙花10~20份,决明子10~20份,茯苓10~20份,白扁豆10~20份,龙胆草10~20份,枸杞10~20份,陈皮10~20份,甘草10~20份,天花粉10~20份,栀子10~20份,佛手10~20份,地骨皮10~20份,益母草10~20份,枸杞10~20份,谷精草10~20份,玫瑰茄10~20份,夏枯草10~20份,合欢花10~20份。
其所述保健饮料配方中还可以包括以下重量份的原料药:菊花10~50份,青葙子10~15份,麦冬10~15份,酸枣仁10~15份,密蒙花10~15份,决明子10~15份,茯苓10~15份,白扁豆10~15份,龙胆草10~15份,枸杞10~15份,陈皮10~15份,甘草10~15份,天花粉10~20份,栀子10~20份,佛手10~20份,地骨皮10~20份,益母草10~20份,枸杞10~20份,谷精草10~20份,玫瑰茄10~20份,夏枯草10~20份,合欢花10~20份。
其所述保健饮料配方中也可以包括以下重量份的原料药:菊花10~50份,青葙子10~20份,麦冬10~20份,酸枣仁10~20份,密蒙花10~20份,决明子10~20份,茯苓10~20份,白扁豆10~20份,龙胆草10~20份,枸杞10~20份,陈皮10~20份,甘草10~20份,天花粉10~15份,栀子10~15份,佛手10~15份,地骨皮10~15份,益母草10~15份,枸杞10~15份,谷精草10~15份,玫瑰茄10~15份,夏枯草10~15份,合欢花10~15份
为解决上述技术问题,本发明还提供一种保健饮料的制备方法,其所述保健饮料的制备方法包括以下步骤:
a.菊花的萃取,作为组分1;
b.其他原料的制备,作为组分2;
c.将上述两种提取液组分1和组分2合并,浓缩后加糊精调和制粒,消毒杀菌后制备成保健饮料冲剂。
所述步骤a中,可以在秋季将采集的白菊切碎,将其浸泡置于有盖不锈钢桶内,加70%乙醇液,质量为粗颗粒的0.8-1倍,搅拌均匀,湿润密闭放置1小时以上,使充分膨胀;将渗漉筒底部滤板用纱布袋包裹铺平后再将湿润膨胀后的药物样品拌松弄散,然后用不锈钢勺盛粉,均匀的装入渗漉筒,装10-12厘米厚,用T型棒压匀,再按上述操作,一层一层的装入,适当加压,药粉填装不得超过渗漉筒的2/3高处;药粉面上盖不锈钢孔板压牢,打开渗漉筒下面的放料阀,并放一容器,然后缓缓加入70%乙醇液;待排出药粉粉粒之间的空气,并有乙醇流出约20L左右,关闭放料阀,盖上漉筒、浸渍24小时,然后开放料阀进行渗漉,控制渗漉速度一般为1000g药材每分钟流出2~3ml,滤液放入贮液缸内,并将排空时的乙醇液倒入贮液缸;将渗滤液合并静置,静置备用,作为组分1。
所述步骤b中,可以将其余原料泡入10倍量乙醇中2-3天后,加热提取2次,每次1-2小时,去上清液,合并提取液,100-110目滤过,再经截流分子量为6000-10000的超滤柱超滤,超滤液减压浓缩相对密度为80℃时1.25的滤液,静置备用,成组分2。
所述步骤c中,可以将上述步骤提取的两种提取液,放入双效真空浓缩器中混合,先将滤液浓缩至80℃时相对密度为1.32的浓缩液,置0~5℃低温冷藏24小时;将冷藏液加0.3%的助滤剂硅藻土,过滤,滤液再置入双效真空浓缩器中,浓缩至每1ml含0.1g浸膏,加糊精调和制粒,消毒杀菌后制备成保健保健饮料冲剂。
为解决上述技术问题,本发明也提供一种保健饮料的制备方法,所述保健饮料的制备方法还可以包括以下步骤:
a.菊花的制备,作为组分1;
b.将所述其余原料药切碎提取作为组分2;
c.将组分1和组分2混合,浓缩后加适量蜂蜜调和,紫外线消毒杀菌后装瓶。
所述步骤a中,可以将采集的白菊花泡入10倍量乙醇中2-7天后,加热提取2次,每次1-2小时,去上清液,合并提取液,100-110目滤过,再经截流分子量为6000-10000的超滤柱超滤,超滤液减压浓缩相对密度为80℃时1.36的浸膏,加热浓缩至膏状,静置备用,成组分1。
所述步骤b中,将其余原料药材混合,切碎过100~120目筛,过筛后细粉备用,粗颗粒放入耐酸碱浸渍锅,在室温下,与70度以上乙醇一起浸渍15~30天,然后加热回流提取2次,每次1~2小时,将2次提取液合并静置,过滤,分离后取滤液;用纱布过滤,残渣中加入50-60%乙醇,60℃-70℃继续浸提2h,每10min搅拌一次,纱布过滤,合并浸提液,浓缩成糊状成为组分2。
本发明的有益效果:本发明使用白菊为主要原料。本发明滋补肝肾、益阴养血、补虚益精气,祛风明目,滋补肝肾的功效,针对性更强本;针对都市上班族普遍使用电脑办公久视,烟酒无度,夜生活不节制、熬夜、过度用眼总得不到缓解等伤害肝脏的行为,以白菊花为主料,加上一些滋肝补肾、清肝明目,口感清淡的中药,共同作用,对肝阴亏损,两目干涩、视力减退;肝火上炎,目赤肿痛;对用眼过度造成眼睛发干发涩有良好的保健作用。本发明选取的这些药材大多口感清淡,并且药效显著,可以长期服用,还不影响白菊味道,使人易于接受,可以长期服用。
具体实施方式
菊花,多年生菊科草本植物,是经长期人工选择培育出的名贵观赏花卉,也称艺菊,品种已达千余种。菊花是中国十大名花之一,在中国已有三千多年的栽培历史,中国菊花传入欧洲,约在明末清初开始。其中产地湖北大别山麻城福田河的福白菊,浙江桐乡的杭白菊和黄山脚下的黄山贡菊(徽州贡菊)比较有名。产于安徽亳州的亳菊、滁州的滁菊、四川中江的川菊、浙江德清的德菊、河南济源的怀菊花(四大怀药之一)都有很高的药效。特别是黄山贡菊,它生长在高山云雾之中,采黄山之灵气,汲皖南山水之精华,它的无污染性对现代人来说,具有更高的饮用价值。菊花的功效与作用:味微辛、甘、苦,性微寒。能疏散风热,清肝明目,平肝阳,解毒。用于感冒风热,发热头昏;肝经有热;目赤多泪,或肝肾阴虚,眼目昏花;肝阳上亢,眩晕头痛;疮疡肿痛。现代又用于冠心病、高血压病。
青葙子为苋科植物一年生草本青葙和鸡冠花的干燥种子,别名野鸡冠花子、鸡冠花子。有野生,亦有栽培,全国各地均有生产。青葙种子和鸡冠花种子两者极相似,均呈扁圆形或双凸镜形,边缘较薄,中心较厚。直径约1~1.5毫米,厚约0.5毫米。色黑,平滑光亮。在扩大镜下观察可见表面有网状纹,网纹呈矩形或多角形,排列成整齐的同心环。基部稍下凹处为种脐,中央有稍突起的脊,种皮薄,剥去种皮,子仁黄白色,饱含油质。气微,味淡,以色黑亮者为佳。功效与作用:中医实验认为有祛风热、清肝火和明目等作用,其原理大概与消炎作用有关。
麦冬百合科沿阶草属多年生常绿草本植物,根较粗,中间或近末端常膨大成椭圆形或纺锤形的小块根,茎很短,叶基生成丛,禾叶状,苞片披针形,先端渐尖,种子球形,花期5-8月,果期8-9月。麦冬原产中国,日本、越南、印度也有分布。中国南方等地均有栽培。生于海拔2000米以下的山坡阴湿处、林下或溪旁。现代药理研究也表明,麦冬主要含沿阶草苷、甾体皂苷、生物碱、谷甾醇、葡萄糖、氨基酸、维生素等,具有抗疲劳、清除自由基、提高细胞免疫功能以及降血糖的作用。另外,麦冬有镇静、催眠、抗心肌缺血、抗心律失常、抗肿瘤等作用,尤其对增进老年人健康具有多方面功效。
酸枣仁,别名枣仁、酸枣核、山枣仁。由鼠李科乔木酸枣成熟果实去果肉、核壳,收集种子,晒干而成。生于向阳山坡、路旁,主要产于河南、河北、陕西、辽宁、山西、山东、云南等地。秋季果实成熟时采收,去果肉及硬核,取种子,生用或微炒用。中国最早的一部药书《神农本草经》中记载:“补中益肝,坚筋骨,助阴气,皆酸枣仁之功也。”明代李时珍《本草纲目》中记载,枣仁“熟用疗胆虚不得眠,烦渴虚汗之症;生用疗胆热好眠,皆足厥阴少阳药也。治虚烦不眠,惊悸怔忡,烦渴,虚汗。
密蒙花,又名:染饭花、九里香、小锦花、蒙花、黄饭花、疙瘩皮树花、鸡骨头花,为马钱科、醉鱼草属灌木,高1-4米。小枝略呈四棱形,灰褐色;小枝、叶下面、叶柄和花序均密被灰白色星状短绒毛,为马钱科植物密蒙花的干燥花或花蕾,有祛风、凉血、润肝、明目的作用,可治目赤肿痛,多泪羞明,青盲翳障,风弦烂眼。生海拔200-2800米向阳山坡、河边、村旁的灌木丛中或林缘,分布于中国、不丹、缅甸、越南。清热泻火,养肝明目,退翳,用于目赤肿痛,多泪羞明,目生翳膜,肝虚目暗,视物昏花。
决明子,是豆科植物决明或小决明的干燥成熟种子,以其有明目之功而名之。秋季采收成熟果实,晒干,打下种子,除去杂质。决明子味苦、甘、咸,性微寒,入肝、肾、大肠经;润肠通便,降脂明目,清肝明目,利水通便,有缓泻作用,降血压降血脂,用于目赤涩痛,羞明多泪,头痛眩晕,目暗不明,大便秘结。
茯苓,为多孔菌科真菌茯苓的干燥菌核。多于7~9月采挖,挖出后除去泥沙,堆置“发汗”后,摊开晾至表面干燥,再“发汗”,反复数次至现皱纹、内部水分大部散失后,阴干,称为“茯苓个”;或将鲜茯苓按不同部位切制,阴干,分别称为“茯苓块”和“茯苓片”。用于水肿尿少,痰饮眩悸,脾虚食少,便溏泄泻,心神不安,惊悸失眠。
白扁豆,可晒干,炒后可食用,别名藊豆、白藊豆、南扁豆;一年生缠绕草本植物扁豆的成熟种子,一年生缠绕草本,茎光滑,羽状三出复叶,小叶3,顶生小叶宽三角状,侧生小叶斜卵形,托叶小,披针形。总状花序腋生,直立,花序轴粗壮;花2至多朵;小苞片2,脱落;萼阔钟状,萼齿5,不等;花冠蝶形,白色或紫红色,长约2厘米,旗瓣基部具耳。荚果倒卵状长椭圆形,微弯,扁平,长5—7厘米;种子2—5,白色或紫黑色,长约8毫米。花期7—8月,果期9一10月。成熟后呈扁椭圆形或扁卵圆形,长约0.8-1.2cm,宽0.6-0.9cm,厚0.4-0.7cm。表面黄白色,平滑而光泽,一侧边缘有半月形白色突起的种阜,约占周径的1/3—1/2,剥去后可见凹陷的种脐,紧接种阜一端有1珠孔,另端有短的种脊。质坚硬。种皮薄脆,内有子叶2枚,肥厚,黄白色,角质。嚼之有豆腥气。花期7-9月;果期9-11月。其性味甘微湿,入脾胃二经,有补脾胃,和中化湿,消暑解毒的功效,主治脾胃虚弱、泄泻、呕吐、暑湿内蕴、脘腹胀痛、赤白带下等病,又能解酒毒。
龙胆草原名:龙胆,别名:胆草、草龙胆、山龙胆。龙胆科、龙胆属多年生草本,根茎平卧或直立,具多数粗壮、略肉质的须根。枝单生,直立,黄绿色或紫红色,中空,近圆形,具条棱,棱上具乳突,稀光滑。枝下部叶膜质,淡紫红色,鳞片形,先端分离,中部以下连合成筒状抱茎;产内蒙古、黑龙江、吉林、辽宁、贵州,陕西、湖北、湖南、安徽、江苏、浙江、福建、广东、广西。生于山坡草地、路边、河滩、灌丛中、林缘及林下、草甸,海拔400-1700米。在苏联、朝鲜、日本也有分布。味苦,性寒。归肝、胆经。清热燥湿;泻肝定惊。湿热黄疸;小便淋痛;阴肿阴痒;湿热带下;肝胆实火之头胀头痛;目赤肿痛;耳聋耳肿;胁痛口苦;热病惊风抽搐。
陈皮,中药名。为芸香科植物橘及其栽培变种的干燥成熟果皮。药材分为“陈皮”和“广陈皮”。采摘成熟果实,剥取果皮,晒干或低温干燥。用于脘腹胀满,食少吐泻,咳嗽痰多。
甘草,别名:国老、甜草、乌拉尔甘草、甜根子。豆科、甘草属多年生草本,根与根状茎粗壮,是一种补益中草药。对人体很好的一种药,药用部位是根及根茎,药材性状根呈圆柱形,长25~100厘米,直径0.6~3.5厘米。外皮松紧不一,表面红棕色或灰棕色。根茎呈圆柱形,表面有芽痕,断面中部有髓。气微,味甜而特殊。功能主治清热解毒、祛痰止咳、脘腹等。喜阴暗潮湿,日照长气温低的干燥气候。甘草多生长在干旱、半干旱的荒漠草原、沙漠边缘和黄土丘陵地带。根和根状茎供药用。功效:1.用于心气虚,心悸怔忡,脉结代,以及脾胃气虚,倦怠乏力等。前者,常与桂枝配伍,如桂枝甘草汤、炙甘草汤。后者,常与党参、白术等同用,如四君子汤、理中丸等。2.用于痈疽疮疡、咽喉肿痛等。可单用,内服或外敷,或配伍应用。痈疽疮疡,常与金银花、连翘等同用,共奏清热解毒之功,如仙方活命饮。咽喉肿痛,常与桔梗同用,如桔梗汤。若农药、食物中毒,常配绿豆或与防风水煎服。3.用于气喘咳嗽。可单用,亦可配伍其他药物应用。如治湿痰咳嗽的二陈汤;治寒痰咳喘的苓甘五味姜辛汤;治燥痰咳嗽的桑杏汤;治热毒而致肺痈咳唾腥臭脓痰的桔梗汤;治咳唾涎沫的甘草干姜汤等。另风热咳嗽、风寒咳嗽、热痰咳嗽亦常配伍应用。4.用于胃痛、腹痛及腓肠肌挛急疼痛等甘草的图片(20张),常与芍药同用,能显著增强治挛急疼痛的疗效,如芍药甘草汤。5.用于调和某些药物的烈性。如调味承气汤用本品缓和大黄、芒硝的泻下作用及其对胃肠道的刺激。另外,在许多处方中也常用本品调和诸药。7甘草有类似肾上腺皮质激素样作用。对组胺引起的胃酸分泌过多有抑制作用;并有抗酸和缓解胃肠平滑肌痉挛作用。8.甘草黄酮、甘草浸膏及甘草次酸均有明显的镇咳作用;祛痰作用也较显著,其作用强度为甘草酸>甘草黄酮>甘草浸膏。9.甘草还有抗炎,抗过敏作用,能保护发炎的咽喉和气管粘膜。甘草浸膏和甘草酸对某些毒物有类似葡萄糖醛酸的解毒作用。10.甘草常用来治疗随更年期而来的症状.因为甘草里含有甘草素,是一种类似激素的化合物,它有助于平衡女性体内的激素含量。11.甘草所含的次酸能阻断致癌物诱发肿瘤生长的作用。
天花粉,药肆之所谓天花粉者,即以萎根切片用之,有粉之名,无粉之实。天花粉为葫芦科植物栝蒌的根,是一种中药,为清热泻火类药物,其具体功效是清热泻火,生津止渴,排脓消肿。主治:治热病口渴、消渴、黄疸、肺燥咳血、痈肿、痔痿。对于治疗糖尿病,常用它与滋阴药配合使用,以达到标本兼治的作用。
栀子,别名:黄栀子、山栀、白蟾,是茜草科植物栀子的果实。栀子的果实是传统中药,属卫生部颁布的第l批药食两用资源,具有护肝、利胆、降压、镇静、止血、消肿等作用。在中医临床常用于治疗黄疸型肝炎、扭挫伤、高血压、糖尿病等症。
佛手,果实在成熟时各心皮分离,形成细长弯曲的果瓣,状如手指,故名佛手。常绿灌木或小乔木,高达丈余,茎叶基有长约6厘米的硬锐刺,新枝三棱形。单叶互生,长椭圆形,有透明油点。花多在叶腋间生出,常数朵成束,其中雄花较多,部分为两性花,花冠五瓣,白色微带紫晕,春分至清明第一次开花,常多雄花,结的果较小,另一次在立夏前后,9-10月成熟,果大供药用,皮鲜黄色,皱而有光泽,顶端分歧,常张开如手指状,故名佛手,肉白,无种子。根、茎、叶、花、果均可入药,辛、苦、甘、温、无毒;入肝、脾、胃三经,有理气化痰、止呕消胀、舒肝健脾、和胃更多种药用功能。对老年人的气管炎、哮喘病有明显的缓解作用;对一般人的消化不良、胸腹胀闷,有更为显著的疗效。佛手可制成多种中药材,久服有保健益寿的作用。
地骨皮,别名:枸杞皮,为茄科、枸杞属植物,是枸杞的根皮。可入药,具有退热除蒸之效,凉血除蒸、清肺降火等功效。常生于山坡、荒地、丘陵地、盐碱地、路旁及村边宅旁,分布于我国东北、河北、山西、陕西、甘肃南部以及西南、华中、华南和华东各省区;朝鲜,日本,欧洲有栽培或逸为野生。
益母草,又名:蓷、茺蔚、坤草、九重楼、云母草、森蒂,为唇形科、益母草属植物,夏季开花。其干燥地上部分为常用中药,中国大部分地区均产,生用或熬膏用。一年或二年生草本全国大部分地区均有分布,生于山野荒地、田埂、草地等。在夏季生长茂盛花未全开时采摘,味辛苦、凉,活血、祛淤、调经、消水,治疗妇女月经不调,胎漏难产,胞衣不下,产后血晕,瘀血腹痛,崩中漏下,尿血、泻血,痈肿疮疡。
谷精草,一年生草本,须根细软稠密,叶基生,长披针状条形。头状花序呈半球形,底部有苞片层层紧密排列,苞片淡黄绿色,上部边缘密生白色短毛,花序顶部灰白色。花茎纤细,长短不一,淡黄绿色,有光泽,稍扭曲,有棱线数条。蒴果3裂。主产于中国江苏苏州、宜兴、溧阳,浙江吴兴、湖州、相乡,湖北黄岗、咸宁、孝感等地。中国多数地区以该种植物全草作谷精草入药,秋季开花结珠时采收,晒干。具有疏散风热,明目退翳的功效。用于肝经风热、目赤肿痛、目生翳障、风热头痛、夜盲症等症。
玫瑰茄,中药名。为锦葵科植物玫瑰茄的根、种子。略呈圆锥状或不规则形,长2.5~4cm,直径约2cm,花萼紫红色至紫黑色,5裂,裂片披针形,下部可见与花萼愈合的小苞片,约10裂,披针形,基部具有去除果实后留下的空洞。花冠黄棕色,外表面有线状条纹,内表面基部黄褐色,偶见稀疏的粗毛。体轻,质脆。气微清香,味酸。敛肺止咳,降血压,解酒。
夏枯草,别名:麦穗夏枯草、铁线夏枯草(云南丛书),麦夏枯、铁线夏枯(滇南本草),夕句、乃东(本经)等;为多年生草本植物,匍匐根茎,节上生须根。茎高达30厘米,基部多分枝,浅紫色。花萼钟形,花丝略扁平,花柱纤细,先端裂片钻形,外弯。花盘近平顶。小坚果黄褐色,花期4-6月,果期7-10月。夏枯草生长在山沟水湿地或河岸两旁湿草丛、荒地、路旁,广泛分布于中国各地,以河南、安徽、江苏、湖南等省为主要产地。夏枯草适应性强,整个生长过程中很少有病虫害。有清火明目之功效,能治目赤肿痛、头痛等。
合欢花是豆科,合欢属落叶乔木,喜温暖湿润和阳光充足环境,气微香,味淡。产中国东北至华南及西南部各省区。生于山坡或栽培。非洲、中亚至东亚均有分布;北美亦有栽培。合欢花花丝粉红色,荚果偏,心材黄灰褐,嫩叶可食,老叶可以洗衣服;树皮供药用,有驱虫之效。它还有宁神作用,主要是治郁结胸闷、失眠健忘、滋阴补阳、眼疾、神经衰弱等功效。
具体实施例1:
菊花的制备:在9~11月采收品相好的白菊花,簸去杂质,洗净,晒干;将晒干的白菊花放入乙醇中萃取,作为组分1。
其他原料的制备:其他原料泡入10倍量乙醇中2-3天后,加热提取2次,成组分2。
混合:将制备好的白菊花萃取液和其他原料提取液混合,浓缩后,加糊精或蜂蜜制粒,作为颗粒冲剂,饮用时用温开水冲泡。
具体实施例2:
秋季将采集的白菊大约5000g切碎,将其浸泡置于有盖不锈钢桶内,加70%乙醇液,质量为粗颗粒的0.8-1倍,搅拌均匀,湿润密闭放置1小时以上,使充分膨胀;将渗漉筒底部滤板用纱布袋包裹铺平后再将湿润膨胀后的药物样品拌松弄散,然后用不锈钢勺盛粉,均匀的装入渗漉筒,装10-12厘米厚,用T型棒压匀,再按上述操作,一层一层的装入,适当加压,药粉填装不得超过渗漉筒的2/3高处;药粉面上盖不锈钢孔板压牢,打开渗漉筒下面的放料阀,并放一容器,然后缓缓加入70%乙醇液;待排出药粉粉粒之间的空气,并有乙醇流出约20L左右,关闭放料阀,盖上漉筒、浸渍24小时,然后开放料阀进行渗漉,控制渗漉速度一般为1000g药材每分钟流出2~3ml,滤液放入贮液缸内,并将排空时的乙醇液倒入贮液缸;将渗滤液合并静置,静置备用,作为组分1。将其余原料青葙子1000g,麦冬1000g,酸枣仁1000g,密蒙花1000g,决明子1000g,茯苓1000g,白扁豆1000g,龙胆草1000g,枸杞1000g,陈皮1000g,甘草1000g,天花粉1000g,栀子1000g,佛手1000g,地骨皮1000g,益母草1000g,枸杞1000g,谷精草1000g,玫瑰茄1000g,夏枯草1000g,合欢花1000g,泡入10倍量乙醇中2-3天后,加热提取2次,每次1-2小时,去上清液,合并提取液,100-110目滤过,再经截流分子量为6000-10000的超滤柱超滤,超滤液减压浓缩相对密度为80℃时1.25的滤液,静置备用,成组分2。将上述步骤提取的两种提取液,放入双效真空浓缩器中混合,先将滤液浓缩至80℃时相对密度为1.32的浓缩液,置0~5℃低温冷藏24小时;将冷藏液加0.3%的助滤剂硅藻土,过滤,滤液再置入双效真空浓缩器中,浓缩至每1ml含0.1g浸膏,加糊精调和制粒,消毒杀菌后制备成保健保健饮料冲剂。然后即可包装出品,可分装成10-15克的小茶包,也可整体混合成袋出售。
具体实施例3:
秋季将采集的白菊大约5000g切碎,将采集的白菊花泡入10倍量乙醇中2-7天后,加热提取2次,每次1-2小时,去上清液,合并提取液,100-110目滤过,再经截流分子量为6000-10000的超滤柱超滤,超滤液减压浓缩相对密度为80℃时1.36的浸膏,加热浓缩至膏状,静置备用,成组分1。将其余原料药材青葙子1100g,麦冬1200g,酸枣仁1200g,密蒙花1100g,决明子1000g,茯苓1000g,白扁豆1100g,龙胆草1000g,枸杞1200g,陈皮1200g,甘草1000g,天花粉1000g,栀子1100g,佛手1200g,地骨皮1300g,益母草1200g,枸杞1200g,谷精草1000g,玫瑰茄1100g,夏枯草1000g,合欢花1000g混合,切碎过100~120目筛,过筛后细粉备用,粗颗粒放入耐酸碱浸渍锅,在室温下,与70度以上乙醇一起浸渍15~30天,然后加热回流提取2次,每次1~2小时,将2次提取液合并静置,过滤,分离后取滤液;用纱布过滤,残渣中加入50-60%乙醇,60℃-70℃继续浸提2h,每10min搅拌一次,纱布过滤,合并浸提液,浓缩成糊状成为组分2。将上述步骤提取的两种提取液,放入双效真空浓缩器中混合,先将滤液浓缩至80℃时相对密度为1.32的浓缩液,置0~5℃低温冷藏24小时;将冷藏液加0.3%的助滤剂硅藻土,过滤,滤液再置入双效真空浓缩器中,浓缩至每1ml含0.1g浸膏,加糊精调和制粒,消毒杀菌后制备成保健保健饮料冲剂。然后即可包装出品,可分装成10-15克的小茶包,也可整体混合成袋出售。
药理学毒性试验
急性毒性实验
一、试验材料:
动物:昆明种小鼠,体重21-24g,雌雄各半,山东大学生物试验室育种。实验物:本发明煎煮液。
二、方法:
1、LD50计算:采用改良寇氏法,将小鼠随机分成5组,每组10只,雌雄各半,将本发明加蒸馏水溶解,配成最大浓度,按小鼠最大允许容量给药,所给剂量按生药量依次为18,14.4,11.5,9.2,7.4(g.kg-1),在动物禁食(不禁水)18小时后,一日内分两次给药(间隔半小时),每次0.5ml,观察动物死亡情况。
2、最大耐受剂量测定(MTD值):取小鼠20只,雌雄各10只。将本发明加蒸馏水溶解,配成最高浓度,按动物的最大耐受量,以注射灌喂器能抽动为准。在动物禁食(不禁水)18小时后,一日内分两次给药(间隔半小时),每次0.5ml(每ml含生药0.36g),总药量为18g生药/kg.d,相当临床成人50Kg体重用量的300倍。给药后连续观察7天。
三、试验结果:
在LD50计算中当用最大允许浓度和最大允许容量给予小鼠时(18g/Kg.d),未见小鼠死亡,即未测出LD50,只可求最大耐受剂量,在7天观察期中,动物其食欲、活动、毛色、精神状态等皆正常,发育正常,未见有死亡。即选用相当于临床剂量的300倍药量,并无不良反应发生,表明急性毒性极小,MTD>18g/Kg.d。
实验例2:长期毒性实验资料
本发明的煎煮剂经灌胃给药6个月的动物长期毒性试验结果:SD大鼠分成三组,每组30只,雌雄各半(分成高、中、低三个剂量组,每组10只),其中第一组经灌胃给生理盐水;第二组经灌胃给本发明的剂量为0.25g、2.5g和12.5g/kg.d;第三组经灌胃给洛伐他汀的剂量为0.5mg、5.0mg和50.0mg/kg.d。在给药期间,分别观察各组动物给药后的临床表现、血液学、血生化、脏器系数和组织病理学等指标进行药物毒性的评价。研究结果:主要毒性反应表现在洛伐他汀50mg/kg.d和5.0mg组,表现在给药后SD大鼠出现了流涎、毛蓬松、忙碌、腹泻、踏脚等反应和症状,总摄食量和体重减轻;血液检查显示白细胞总数有所增加,红细胞总数、血红蛋白含量和血小板计数明显下降(P均<0.05);血液生化检查显示ALT、AST、ALP和CK升高1~8倍(P均<0.05),肌酐和尿素氮有所升高(P均<0.05),但未引起动物死亡;组织病理学分析结果显示洛伐他汀50mg/kg.d组出现了与人相似的肝肾病理改变。而生理盐水组和本发明0.25g、2.5g和12.5g/kg.d三个剂量组和洛伐他汀0.5mg/kg.d剂量组在整个给药期间均未出现类似反应,在恢复期观察期间,出现反应的各组动物的症状逐渐消失恢复正常状态。可见本发明不但能够降低洛伐他汀的毒副作用,而且可使洛伐他汀的临床无毒剂量增加至5~25倍(P均<0.01)。
试验例3:累积毒性实验:
本发明煎煮剂对小鼠按7.69、19.18和43.21g生药/kg连续用药15周(1.0ml/100g体重,每天2次)及停药3周后,结果表明:本发明中药制剂对大鼠的毛发、行为、大小便、体重、脏器重量、血象、肝肾功能、血糖、血脂等指标均无明显影响,脏器肉眼没有发现异样变化和组织学检查结果表明,用药15周及停药3周后,大鼠各脏器均无明显改变。说明本发明中药制剂对大鼠长期用药后毒性小,停药后也没有异样反应,应用安全。
药理学实验说明:
1实验材料
1.1药品
本发明平肝明目的菊花保健饮料(用实施例2的方法制备);阳性对照药:杞菊地黄丸,同仁堂出品,市售。
1.2动物Wistar大鼠,昆明种小鼠,♀♂均用。
2对肝损伤小鼠血清中ALT、ET、NO含量的影响
2.1分组:取90只昆明小鼠随机分为6组,每组15只,A组为正常对照组;B组为模型对照组;C组为阳性对照组;D1组为本发明低剂量组,D2组为本发明中剂量组,D3组为本发明高剂量组;
2.2造模方法:采用卡介苗和脂多糖联合的方法建立免疫性肝损伤小鼠模型。各组动物适应性喂养3d后,除正常对照组外,每只小鼠1次尾静脉注射卡介苗5×107个活菌,于注射BCG后第12d静脉注射脂多糖7.5μg/鼠,于16h后处死取材,正常对照组2次都以相同方法注射等量生理盐水。
2.3给药与处理:静脉注射卡介苗的第一天起开始灌胃给药,1次/d。正常对照组与模型对照组:生理盐水灌胃,灌胃量同药物治疗组的用药容量;阳性对照药物治疗组:杞菊地黄丸,5.9g/kg剂量给药;本发明组低3.9g/kg、中7.8g/kg、高11.7g/kg剂量给药。正常对照组于第12d注射生理盐水后16h,眼球后静脉丛取血,并处死动物取肝组织送检;其余组于静脉注射脂多糖后16h,眼球后静脉丛取血,并处死动物取肝组织送检。
2.4观察指标及检测方法:①检测谷-丙转氨酶(ALT):采用化学比色法测定。②内源性一氧化氮(N0)测定:采用放射免疫法,剖取0.5g肝脏制成10%肝组织匀浆,在4℃条件下,3000转/min,离心10min,取上清液。③内皮素(ET)检测:采用放射免法直接测定血浆ET浓度。
表1各组血清ALT、ET、N0的变化情况比较
组别 | n | 剂量 | ALT(nmol*s-1/L) | ET(ng/L) | NOμ(mol/L) |
A | 15 | / | 838. 25± 382. 95 | 49. 46± 16. 34 | 37. 46± 8. 15 |
B | 15 | / | 1223. 12± 851. 74 | 52. 78± 42. 47 | 49. 42±21. 45 |
C | 15 | 5.9g/kg | 1788. 46± 645. 34** | 58. 67± 23. 15* | 46. 21± 10. 23* |
D1 | 15 | 3.9g/kg | 1455. 78± 467. 11**△ | 50. 32± 20.91* | 46. 57± 9. 56*△ |
D2 | 15 | 7.8g/kg | 1546. 37± 432. 16**△ | 54. 21± 18.32* | 46. 55± 7. 35*△ |
D3 | 15 | 11.7g/kg | 1973. 31± 422. 54** | 61. 52± 17. 67* | 47. 32± 8. 15* |
*与模型组比较,*P<0.05、**P<0.01;△与阳性对照组比较,△P<0.05。
3、对慢性肝损伤的保护作用
取40只昆明小鼠随机分为4组,每组10只,大鼠皮下注射10%5ml/kg四氯化碳油溶液,每周2次,连续注射3个月,造成四氯化碳慢性肝损伤动物模型,观察本发明药物对损伤肝的保护作用。
正常对照组(A)与模型对照组(B):生理盐水灌胃,灌胃量同药物治疗组的用药容量;阳性对照药物治疗组(C):杞菊地黄丸,2.7g/kg剂量给药;本发明(D),2.7g/kg剂量给药。正常对照组于第12d注射生理盐水后16h,眼球后静脉丛取血,并处死动物取肝组织送检;其余组于静脉注射脂多糖后16h,眼球后静脉丛取血,并处死动物取肝组织送检。
表2本发明药物对慢性肝损伤大鼠的保护作用(X±SD)
组别 | n | 剂量 | SGPT(卡门氏单位) | SGOT(卡门氏单位) | 羟脯氨酸含量 |
A | 10 | / | 42.19± 27. 04 | 109.37± 14. 63 | 1. 63± 0. 25 |
B | 10 | / | 47. 84± 99. 32 | 106.14± 72. 49 | 2.08± 0. 28 |
C | 10 | 2.7g/kg | 42.46± 29.25** | 112.51± 19. 43** | 1.68± 0. 67 |
D | 10 | 2.7g/kg | 37.78± 14. 24** | 89.43± 16. 42**△ | 1. 66± 0. 24 |
*与模型组比较,*P<0.05、**P<0.01;△与阳性对照组比较,△P<0.05。
从以上结果可以看出,检测合格的本发明药物对肝损伤小鼠血清中ALT、ET、N0含量有显著性改善,并且对慢性肝损伤有明显的的保护作用,与阳性对照药物比较有显著性差异。
临床试验:
一、实验对象:采用本发明中药保健饮料共在100例患者实验,其中男48例,女52例;年龄最大者55岁,年龄最小者18岁。大部分病患均为白领,自述视物模糊、夜盲;失眠健忘、肝阴亏损,两目干涩、视力减退;肝火上炎,目赤肿痛;经常眼睛发干发涩,熬夜,饮酒应酬;且面色晦暗,女病患大都有月经不调,面上起痘,色斑严重。实验组、对照组均50。病症相同或类似,采用市售清肝明目眼药水+中药调理。
治疗方法:
用法用量:治疗组采用本发明中药保健饮料。方用:菊花35g,青葙子13g,麦冬11g,酸枣仁11g,密蒙花11g,决明子12g,茯苓12g,白扁豆13g,龙胆草11g,枸杞12g,陈皮12g,甘草12g,天花粉12g,栀子12g,佛手12g,地骨皮11g,益母草12g,枸杞11g,谷精草12g,玫瑰茄11g,夏枯草13g,合欢花11g。其用法与用量如下:每天2袋次,每次冲泡两次为限。疗程:一个月为限。对照组每日服用中药成药(杞菊地黄丸)加滴眼药水(珍珠明目滴眼液,市售),一个月为限。
疗效评价标准
治愈:以上症状体征完全改善,患者无任何不良感觉,心情舒畅,精神焕发,眼睛不再发干发涩,视线模糊。显效:体征显著改善,患者基本无不良感觉,心情舒畅,精神很好。有效:体征明显改变,偶感稍有不适,但能接受,心情较好,精力比较充沛。无效:体征无任何改变,症状如前,心情抑郁,精神萎靡不振。面色晦暗,眼睛还是发干发涩。
结果见表1两组疗效比较(%)
组别 | 人数 | 痊愈 | 显效 | 有效 | 无效 | 总有效率 |
治疗组 | 50 | 37(74) | 11(22) | 2(4) | 0(0) | 100 |
对照组 | 50 | 25(50) | 12(24) | 8(16) | 5(10) | 90 |
讨论:本发明的治疗组效果明显高于对照组。表明本发明保健茶饮代替中药完全可行。本发明的优点是,作为日常饮用,能改善口感,也让人不产生厌恶心理,对中药气味不再排斥。
针对都市上班族普遍使用电脑办公久视,烟酒无度,夜生活不节制、过度用眼总得不到缓解等伤害肝脏的行为,采用补虚益精气,祛风明目,滋补肝肾的中药配伍,并且解决了中药口感不佳,不能长期服用的缺点。
本发明以白菊花为主料,加上一些滋肝补肾、清肝明目,口感清淡的中药,共同作用,对肝阴亏损,两目干涩、视力减退;肝火上炎,目赤肿痛;对用眼过度造成眼睛发干发涩有良好的保健作用。
《本草便读》:甘菊之用,可一言以蔽之,日疏风而已。然虽系疏风之品,而性味甘寒,与羌、麻等辛燥者不同,故补肝肾药中可相需而用也。《本草正义》:凡花皆主宣扬疏泄,独菊花则摄纳下降,能平肝火,熄内风,抑木气之横逆。《本经》主风头眩者,以阴虚阳浮,气火升腾,肝凤上扰之眩晕言之,非外来风邪,能令人眩也。肿痛,连上风头眩三字读。肝火直上顶巅,而为眩,为肿,为痛,阳焰直升,其势最暴。凡是头凤作痛,无非内火内风震撼不息,而菊花能治之,非肃降静镇迥异寻常者,殆难有此力量。目如欲脱,乃肝阳内风之尤甚者。世谓头凤痛甚,至于丧明,抑知且有目珠突出,形如雀卵者。泪出亦阴虚于下,肝火上扬,真阴无摄纳之权,而风阳以疏泄为用,则迎风而泪下,此皆肝肾阴亏,而浮阳上亢为虐,惟菊花之清苦泄降,能收摄虚阳而纳归于下,故为目科要药。又治皮肤死肌,恶风湿痹者,则血热而络脉不洁,渐以积秽成腐。菊花苦辛宣络,能理血中热毒,则污浊去而痹着之死肌可愈。石顽谓清利血脉,而痹着湿邪,得以开泄,持论甚正。惟此是冲和纯粹之品,以清经隧积淤之浊血,断非旦夕可以速效,弗以无近功,而遽疑《经》言之不可信也。菊花疏风较弱,清热力佳,用于外感风热常配酸枣仁同用,也可配黄芩、山栀治热盛烦燥等症。菊花治目赤肿痛,无论属于肝火或风热引起者,均可应用,因本品既能清肝火,又能散风热,常配合蝉衣、白蒺藜等同用。如肝阴不足,眼目昏花,则多配生地、杞子等同用。菊花清热解毒之功甚佳,为外科要药,主要用于热毒疮疡、红肿热痛之症,特别对于疔疮肿痛毒尤有良好疗效,既可内服,又可捣烂外敷。临床上常与地丁草、蒲公英等清热解毒之品配合应用。菊花能平降肝阳,对肝阳上亢引起的头目眩晕,往往与珍珠母、葛藤等配伍应用。菊花一药,主要分白菊、黄菊、野菊。黄、白两菊,都有疏散风热、平肝明目、清热解毒的功效。白菊花味甘、清热力稍弱,长于平肝明目;黄菊花味苦,泄热力较强,常用于疏散风热;野菊花味甚苦,清热解毒的力量很强。野菊的茎、叶,功用与花相似,无论内服与外敷,都有功效。酸枣仁与菊花,均能疏散风热,清泄肺肝,故在外感风热、发热头痛及目赤肿痛等症,两药往往相辅为用。但酸枣仁疏风清肺的功效较好,故治肺燥咳嗽,往往用酸枣仁而不用菊花;菊花则长于平肝阳,且能清热解毒
尽管上文对本发明的具体实施方式给予了详细描述和说明,但是应该指明的是,我们可以依据本发明的构想对上述实施方式进行各种等效改变和修改,其所产生的功能作用仍未超出说明书所涵盖的精神时,均应在本发明的保护范围之内。
Claims (10)
1.一种保健饮料配方及其制备方法,其特征在于,所述保健饮料配方及其制备方法中包括以下重量份的原料药:菊花10~50份,青葙子10~20份,麦冬10~20份,酸枣仁10~20份,密蒙花10~20份,决明子10~20份,茯苓10~20份,白扁豆10~20份,龙胆草10~20份,陈皮10~20份,甘草10~20份,天花粉10~20份,栀子10~20份,佛手10~20份,地骨皮10~20份,益母草10~20份,谷精草10~20份,玫瑰茄10~20份,夏枯草10~20份,合欢花10~20份。
2.根据权利要求1所述保健饮料配方及其制备方法,其特征在于,所述保健饮料配方及其制备方法中还包括以下重量份的原料药:菊花10~50份,青葙子10~15份,麦冬10~15份,酸枣仁10~15份,密蒙花10~15份,决明子10~15份,茯苓10~15份,白扁豆10~15份,龙胆草10~15份,陈皮10~15份,甘草10~15份,天花粉10~20份,栀子10~20份,佛手10~20份,地骨皮10~20份,益母草10~20份,谷精草10~20份,玫瑰茄10~20份,夏枯草10~20份,合欢花10~20份。
3.根据权利要求1所述保健饮料配方及其制备方法,其特征在于,所述保健饮料配方及其制备方法中也包括以下重量份的原料药:菊花10~50份,青葙子10~20份,麦冬10~20份,酸枣仁10~20份,密蒙花10~20份,决明子10~20份,茯苓10~20份,白扁豆10~20份,龙胆草10~20份,陈皮10~20份,甘草10~20份,天花粉10~15份,栀子10~15份,佛手10~15份,地骨皮10~15份,益母草10~15份,谷精草10~15份,玫瑰茄10~15份,夏枯草10~15份,合欢花10~15份。
4.一种如权利要求1~3中任一项所述保健饮料配方及其制备方法的制备方法,其特征在于,所述保健饮料的制备方法包括以下步骤:
a.菊花的萃取,作为组分1;
b.其他原料的制备,作为组分2;
c.将上述两种提取液组分1和组分2合并,浓缩后加糊精调和制粒,消毒杀菌后制备成保健饮料冲剂。
5.根据权利要求4所述保健饮料配方及其制备方法的制备方法,其特征在于:所述步骤a中,秋季将采集的白菊切碎,将其浸泡置于有盖不锈钢桶内,加70%乙醇液,质量为粗颗粒的0.8-1倍,搅拌均匀,湿润密闭放置1小时以上,使充分膨胀;将渗漉筒底部滤板用纱布袋包裹铺平后再将湿润膨胀后的药物样品拌松弄散,然后用不锈钢勺盛粉,均匀的装入渗漉筒,装10-12厘米厚,用T型棒压匀,再按上述操作,一层一层的装入,适当加压,药粉填装不得超过渗漉筒的2/3高处;药粉面上盖不锈钢孔板压牢,打开渗漉筒下面的放料阀,并放一容器,然后缓缓加入70%乙醇液;待排出药粉粉粒之间的空气,并有乙醇流出约20L左右,关闭放料阀,盖上漉筒、浸渍24小时,然后开放料阀进行渗漉,控制渗漉速度一般为1000g药材每分钟流出2~3ml,滤液放入贮液缸内,并将排空时的乙醇液倒入贮液缸;将渗滤液合并静置,静置备用,作为组分1。
6.根据权利要求4所述保健饮料配方及其制备方法的制备方法,其特征在于,所述步骤b中,将其余原料泡入10倍量乙醇中2-3天后,加热提取2次,每次1-2小时,去上清液,合并提取液,100-110目滤过,再经截流分子量为6000-10000的超滤柱超滤,超滤液减压浓缩相对密度为80℃时1.25的滤液,静置备用,成组分2。
7.根据权利要求4所述保健饮料配方及其制备方法的制备方法,其特征在于,所述步骤c中,将上述步骤提取的两种提取液,放入双效真空浓缩器中混合,先将滤液浓缩至80℃时相对密度为1.32的浓缩液,置0~5℃低温冷藏24小时;将冷藏液加0.3%的助滤剂硅藻土,过滤,滤液再置入双效真空浓缩器中,浓缩至每1ml含0.1g浸膏,加糊精调和制粒,消毒杀菌后制备成保健保健饮料冲剂。
8.一种如权利要求1~3中任一项所述保健饮料配方及其制备方法的制备方法,其特征在于,所述保健饮料配方及其制备方法的制备方法还可以包括以下步骤:
a.菊花的制备,作为组分1;
b.将所述其余原料药切碎提取作为组分2;
c.将组分1和组分2混合,浓缩后加适量蜂蜜调和,紫外线消毒杀菌后装瓶。
9.根据权利要求8所述保健饮料配方及其制备方法的制备方法,其特征在于,所述步骤a中,将采集的白菊花泡入10倍量乙醇中2-7天后,加热提取2次,每次1-2小时,去上清液,合并提取液,100-110目滤过,再经截流分子量为6000-10000的超滤柱超滤,超滤液减压浓缩相对密度为80℃时1.36的浸膏,加热浓缩至膏状,静置备用,成组分1。
10.根据权利要求8所述保健饮料配方及其制备方法的制备方法,其特征在于,所述步骤b中,将其余原料药材混合,切碎过100~120目筛,过筛后细粉备用,粗颗粒放入耐酸碱浸渍锅,在室温下,与70度以上乙醇一起浸渍15~30天,然后加热回流提取2次,每次1~2小时,将2次提取液合并静置,过滤,分离后取滤液;用纱布过滤,残渣中加入50-60%乙醇,60℃-70℃继续浸提2h,每10min搅拌一次,纱布过滤,合并浸提液,浓缩成糊状成为组分。
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