CN105745373A - 抗微生物纺织产品及其获得的方法 - Google Patents
抗微生物纺织产品及其获得的方法 Download PDFInfo
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- CN105745373A CN105745373A CN201480050290.9A CN201480050290A CN105745373A CN 105745373 A CN105745373 A CN 105745373A CN 201480050290 A CN201480050290 A CN 201480050290A CN 105745373 A CN105745373 A CN 105745373A
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Classifications
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- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
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- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
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- D06M13/152—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing oxygen having a hydroxy group bound to a carbon atom of a six-membered aromatic ring
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- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M13/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
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- D06M13/322—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing nitrogen
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- D06M15/00—Treating fibres, threads, yarns, fabrics, or fibrous goods made from such materials, with macromolecular compounds; Such treatment combined with mechanical treatment
- D06M15/01—Treating fibres, threads, yarns, fabrics, or fibrous goods made from such materials, with macromolecular compounds; Such treatment combined with mechanical treatment with natural macromolecular compounds or derivatives thereof
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- D06M15/11—Starch or derivatives thereof
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- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
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Abstract
本发明涉及一种获得抗真菌、抗假丝酵母和抗细菌纺织产品的方法。本发明的目的是获得抗微生物产品，其能够减少由纺织产品传播或蔓延的感染性疾病，减少为确保卫生所花费的额外成本和精力，和增加一次性纺织产品的卫生。一种三氯生、氯己定和八硼酸二钠五水合物的溶液被用于本发明的方法中。所述溶液能够使疏水性纺织产品转化为亲水性产品，从而能够使溶液中的抗微生物剂被编入纺织产品中。
Description
发明领域
本发明涉及一种获得抗真菌、抗假丝酵母和抗细菌纺织产品的方法。
发明背景
致病性、机会性或有益微生物通过使用在表面和潮湿环境中无机和有机营养素，增殖，并在它们定位的区域形成菌落。在表面长时期维持的表面污染和病原体增加环境和医院-获得性感染风险的危险。在文献中已指出，减少环境病原体负荷是医院获得性疾病减少的一个重要步骤(Wenzel和Edmond, 2003)。绝大多数病原体长期生活在表面并引起严重疾病，在经接触和吸入而传播时变得广泛蔓延。已显示耐万古霉素肠球菌菌种(Enterococcus species)，其是这些病原体中最重要的一种，从医院内的门把手、床单、床栏、桌子，墙壁，地板和其它表面分离(Yamaguchie等, 1994)。由于医院的表面适合于微生物生长，在入院几小时后，所述表面上的微生物开始在患者的皮肤上、呼吸道、泌尿和生殖系统中生长和增殖(Nguyen,
2006)。因这些理由，使得在重症监护病房(其中特别是治疗具有受抑制或弱免疫系统的患者)、紧急情况应答中心和其它卫生保健单位、托儿所、幼儿园、公共交通工具和其它公共领域的所有表面上，抗微生物已变成一个重要的领域，其处于科学家们的极大兴趣下。
需要制成抗微生物性的主要表面是连续地和直接接触人皮肤的纺织产品。由于纺织产品富含营养素且许多纺织产品可保留空气中的水分，它们为微生物提供非常便利的条件。在诸如医院等环境中，在那里消毒是极其重要的，通过频繁地洗涤纺织产品来减少污染危险是令人疲惫的，或者一次性产品在使用后被破坏。由于用于卫生保健单位的纺织产品可在其上容纳许多病原体，除了将这些产品除污之外，其上的微生物负荷也应被清除(Fijan等 2005)。虽然没有提供在纺织品上的微生物负荷和感染性疾病之间的直接关系的科学研究，已提出即使在洗涤后，一些微生物物种可在纺织品上生存(Larson,
1999)。此外，一次性产品，即使它们在无菌条件下包装，一旦它们从其包装中取出，便为微生物定植提供合适的环境。由于洗涤和使用一次性产品不能减少在这些地方的微生物负荷，所以需要会降低感染危险和交叉污染并且不会允许其上有任何微生物载荷的抗微生物纺织产品。
一些产品例如构成纺织产品的很大一部分的非织造品是天然疏水性的。然而，在通过使用这些织物开发的各种产品，特别是在卫生用品(例如卫生垫和尿布)中，吸水性是需要的。因此，这种类型的产品，至少其某些部分，应被制成亲水性的。此外，在用水溶性染料进行的涂覆过程中也需要亲水性纺织产品。因此，在将用水溶性染料进行应用之前，应将疏水性纺织产品制成亲水性的。除了这些，为开发抗微生物纺织产品，应使得表面为亲水性的且活性物质应该被允许编入纺织品中。
美国专利文件号US2013152277公开一种服装，其为抗微生物纺织产品。
国际专利文件号WO2013072883公开一种抗真菌、抗假丝酵母和抗细菌纺织产品。
发明简述
本发明的一个目的是获得获得一次性和可重复使用的抗微生物纺织产品。
本发明的另一个目的是获得抗微生物纺织产品，其能够减少经纺织产品传播或蔓延的感染性疾病。
本发明的进一步的目的是获得抗微生物纺织产品，其减少为确保卫生所花费的额外成本和精力。
本发明的又一个目的是获得一种能够将疏水性纺织产品转化为亲水性纺织产品的溶液。
发明详述
用于获得本发明的抗微生物纺织产品而实施的方法的步骤如下：
实验性研究
所进行的研究包括以下步骤：
- 使三氯生溶于glucopon并获得均匀的混合物，
- 将氯己定溶液加入到获得的溶液中，
- 将八硼酸二钠五水合物溶液加入到所述三氯生+氯己定溶液中，且当获得均匀的混合物时，获得抗微生物浸渍溶液，
- 将浸渍溶液装载在纺织产品上，从而使得产品为抗微生物的，
- 使纺织产品通过辊，从而回收过量的溶液，
- 通过使其通过烘箱，干燥装载有浸渍溶液的纺织产品，
- 干燥后，获得最终抗微生物纺织产品。
当实施本发明时，通过于45℃温和地混合，使三氯生粉末以0.001-0.1%的浓度溶于10% glucopan，获得均匀的混合物。20%氯己定溶液以0.05-3%的浓度加入制备的溶液。最后，通过将高纯度和矿化的八硼酸二钠五水合物溶液以0.001-0.1%的浓度混入制备的溶液中，获得均匀的浸渍溶液。
通过工业装置的帮助，将获得的最终混合物装载到纺织产品上，从而将它们制成抗微生物的。在纺织产品通过在浸渍桶中的浸渍溶液后，使它们通过工业辊，从而回收过量的溶液。纺织产品，其用浸渍溶液装载，通过以12米/分钟的速度经过60℃温度的烘箱来干燥。获得的纺织产品对抗细菌、酵母和真菌的抗微生物特性通过使用标准盘扩散法来评价。
特征研究
盘扩散法
荷载有浸渍溶液的纺织产品的抗微生物特性通过使用标准NCCLS盘扩散法检测(Lalitha, 2005)。简言之，包含108 cfu/ml细菌、106 cfu/ml酵母和104 spor/ml真菌的100ul溶液用新的培养物制备并用扩散法分别在胰蛋白酶解酪蛋白大豆琼脂(Trypticase soy agar) (TSA)、沙氏葡萄糖琼脂
(SDA)和马铃薯葡萄糖琼脂(PDA)上接种。将大约1x1
cm的部分(其从用包含所述浓度的三氯生、氯己定和八硼酸二钠五水合物的浸渍溶液装载的纺织产品切割)置于接种的陪替氏培养皿上。未用浸渍溶液装载的空的纺织产品被用作阴性对照。作为阳性对照，对细菌使用氧氟沙星(5
µg/盘)，而对酵母和真菌使用制霉菌素(100
u/盘)。对于细菌，将陪替氏培养皿(其被接种且纺织产品放置于其上)于36±1℃保持24小时，而对于酵母保持48小时，对于真菌于25±1℃保持72小时。在标准盘扩散法中测试的对抗微生物的抗微生物活性通过测量抑制区而评价。所有的试验重复至少两次。测试的纺织产品的抗微生物活性结果概述于表1中。
实验结果
抗微生物试验结果
当对抗测试的微生物的抑制区在所述部分（其从用包含三氯生、氯己定和八硼酸二钠五水合物的浸渍溶液装载的纺织产品切割，所述浸渍溶液通过为获得本发明的抗微生物纺织产品所应用的方法制备）的周围观察到时，对照组中的纺织产品的部分周围未检测到抑制区(表1)。通过使用用浓度最优化的活性分子制备的浸渍溶液，赋予纺织产品抗细菌、抗假丝酵母和抗真菌特性。
表1. 装载有抗微生物浸渍溶液的纺织产品对抗所选择的细菌、真菌和酵母分离物/菌株的体外抗微生物试验结果。
本发明的应用
本发明的产品对大肠杆菌(Escherichia coli)、铜绿假单胞菌(Pseudomonas aeruginosa)、MRSA，和金黄色葡萄球菌(Staphylococcus aureus)细菌；酵母，假丝酵母(Candida spp.)；和真菌菌种，曲霉菌(Aspergillus spp.)和青霉菌(Penicillium spp)是有效的。
在对其施用本发明的疏水性非-纺织样品中，glucopon + 三氯生+氯己定+八硼酸二钠五水合物+蒸馏水((dH2O)的溶液能够通过允许疏水性表面转化为亲水性表面，使抗微生物混合物编入纺织产品。
这些纺织产品可用于：
- 特别是医疗界，用于透析过滤器、创可贴、外科手术服、口罩、帽、外科缝线和帷帘，
- 在服装界；在需要卫生的工作服中的衣服诸如加强布和夹层；
- 内衣和夏装如短裤、比基尼和泳衣，这些服装极其经常地暴露于潮湿下，并为细菌繁殖提供合适的环境，
- 要求卫生的婴儿服装，
- 家用和工作场所用纺织品；地毯、窗帘、室内装饰品、桌布、床单，
- 在公共运输交通工具中要求卫生的枕头休息套和其它纺织产品，
- 可用于包装，储存和运输食品的所有纺织产品，
- 在建筑业中的表面隔板和绝缘材料；在其中可防止微生物增殖和导致腐烂的领域。
参考文献
Wenzel, R. P.和Edmond, M. B.
(2003). "倾听SARS：传染控制的课程（Listening
to SARS: lessons for infection control.）"
Annals of internal medicine 139(7): 592-593.
Yamaguchie, E., Valena, F., Smith, S. M., Simmons, A.和Eng, R. H. (1994). "耐万古霉素的粪肠球菌(Enterococcus faecium)的定植模式(Colonization pattern of vancomycin-resistant
Enterococcus faecium)".
American journal of infection control 22(4): 202-206.
Nguyen, Q. V. (2006). "医院获得性感染(Hospital-acquired
infections)." eMedicine, August 21.
Fijan, S., Sostar-Turk, S.和Cencic, A. (2005). "在医院洗衣房实施卫生监测系统以减少医院纺织品的微生物污染(Implementing hygiene monitoring systems
in hospital laundries in order to reduce microbial contamination of hospital
textiles)." The Journal of hospital infection 61(1): 30.
Larson, E. L. (1999). " 家庭卫生：新千年再度出现的问题(Home
hygiene: a reemerging issue for the new millennium.)" American journal of
infection control 27(6): S1-S3.
Lalitha, M. (2005).
"抗微生物敏感性试验手册(Manual on antimicrobial susceptibility
testing)." http://www.ijmm.org/documents/Antimicrobia.doc.
Claims (12)
1. 一种包括以下步骤的方法：
- 使三氯生溶于glucopon并获得均匀的混合物，
- 将氯己定溶液加入到所获得的溶液中，
- 将八硼酸二钠五水合物加入到所述溶液混合物中并获得均匀的浸渍溶液，
- 将所述浸渍溶液装载在纺织产品上，从而将所述产品制成抗微生物的，
- 使所述纺织产品通过辊，从而回收所述过量的溶液，
- 通过使其通过烘箱，干燥用浸渍溶液装载的所述纺织产品，
- 干燥后，获得最终的抗微生物纺织产品。
2. 依据权利要求1的方法，其中三氯生于45℃以0.001-0.1%的浓度溶于10% glucopan中，获得均匀的混合物。
3. 依据权利要求1的方法，其中20%的氯己定溶液以0.05-3%的浓度加入到所获得的溶液中。
4. 依据权利要求1的方法，其中八硼酸二钠五水合物以0.001-0.1%的浓度加入到所述溶液中，用于所述均匀的浸渍溶液。
5. 依据权利要求1的方法，其中通过使所述产品以12米/分钟的速度穿过60℃的烘箱来进行干燥。
6. 依据权利要求1的浸渍溶液，其将疏水性纺织品表面转化为亲水性表面并将抗微生物特性编入所述纺织表面。
7. 用依据权利要求1-6的任一项的方法获得的抗微生物纺织产品。
8. 依据权利要求7的纺织产品，其具有对抗细菌、酵母和真菌的抗微生物活性。
9. 依据权利要求8的纺织产品，其有效对抗大肠杆菌(Escherichia coli)、铜绿假单胞菌(Pseudomonas
aeruginosa)、MRSA和金黄色葡萄球菌(Staphylococcus
aureus)的菌种。
10. 依据权利要求8的纺织产品，其有效对抗酵母，假丝酵母(Candida spp)。
11. 依据权利要求8的纺织产品，其有效对抗曲霉菌(Aspergillus spp.)和青霉菌(Penicillium spp)的真菌菌种。
12. 抗微生物纺织产品，其可用于：
- 医疗界：用于透析过滤器、创可贴、外科手术服、口罩、帽、外科缝线和帷帘，
- 在服装界；在需要卫生的工作服中衣服的夹层部分和加强布；夏装如短裤、比基尼和泳衣和内衣，
- 需要卫生的婴儿服装，
- 家用和工作场所用纺织品；地毯、窗帘、室内装饰品、桌布、床单，
- 用于公共运输交通工具的枕头休息套，
- 可用于包装，储存和运输食品的所有纺织产品，
- 在建筑界中的表面隔板（façade
linings）和绝缘材料；在其中可防止微生物繁殖和导致腐烂的领域中。
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| US10125453B2 (en) | 2018-11-13 |
| EP3044361A1 (en) | 2016-07-20 |
| RU2660050C2 (ru) | 2018-07-04 |
| JP6698531B2 (ja) | 2020-05-27 |
| RU2016113704A (ru) | 2017-10-17 |
| JP2016535181A (ja) | 2016-11-10 |
| US20160215442A1 (en) | 2016-07-28 |
| WO2015038080A1 (en) | 2015-03-19 |
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