CN105727434B - A kind of transdermal iontophoresis electrode plate of Chinese medicine and physiotherapy equipment for treating asthma - Google Patents

A kind of transdermal iontophoresis electrode plate of Chinese medicine and physiotherapy equipment for treating asthma Download PDF

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CN105727434B
CN105727434B CN201610062736.0A CN201610062736A CN105727434B CN 105727434 B CN105727434 B CN 105727434B CN 201610062736 A CN201610062736 A CN 201610062736A CN 105727434 B CN105727434 B CN 105727434B
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parts
chinese medicine
asthma
silicon rubber
electrode plate
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CN105727434A (en
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续智元
续棪
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
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    • A61K35/63—Arthropods
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    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
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    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents

Abstract

The invention discloses a kind of transdermal iontophoresis electrode plates of Chinese medicine for treating asthma, including medical grade silicon rubber conductive plate, heater circuit, intermediate-frequency circuit and the Chinese medicine electrode cores for adsorbing Chinese medicine extract with core bore socket, heater circuit and intermediate-frequency circuit are hovered above in medical grade silicon rubber conductive plate and are connect with core bore, adsorb the Chinese medicine electrode cores of Chinese medicine extract in silicon rubber conductive plate；The Chinese medicine extract is by caulis piperis futokadsurae, ganoderma lucidum, Chinese ephedra, asarum, radix scutellariae, the tuber of stemona, fritillaria thunbergii, Exocarpium Citri Rubrum, Cynanchum glaucescens, aster, pheretima, datura flower, ching-chieh, radix saposhnikoviae, cicada is de-, flos caryophylli, semen brassicae, Herba Epimedii, radix aconiti lateralis preparata, cortex cinnamomi, what rhizoma pinellinae praeparata etc. was process by alcohol percolation method, a pair of electrodes plate continual alternating in a dosage period receives symmetrical wave physiologic signal and asymmetrical wave imports signal, drug is set rapidly and uniformly to penetrate into subcutaneous deep, to bronchial asthma, allergic asthma, the treatment for chronic cough of itching is swallowed with quick, eutherapeutic feature.

Description

A kind of transdermal iontophoresis electrode plate of Chinese medicine and physiotherapy equipment for treating asthma
Technical field
The invention belongs to medical instruments field, it is related to a kind of mutually tying electronic technology, software programming control technology with Chinese medicine The physiotherapy equipment of conjunction, more particularly to a kind of transdermal iontophoresis electrode plate of Chinese medicine for treating asthma and physiotherapy equipment.
Background technique
Asthma is one of most common chronic disease in the world, and American-European some western countries' disease incidence are up to 10% or more, China's hair Sick rate about 2%, about 20,000,000 people of asthmatic patient, there are about 300,000,000 people to suffer from asthma in the whole world.About asthma Producing reason, human body is congenital The many reasons such as constitution and heredity, mood, affection of exogenous wind-cold, diet, environment, wherein allergy is the major reason that asthma generates.In Doctor thinks that kidney yang virtual loss, phlegm retention lies prostrate lung, and asthma perennial root is in phlegm, along with composite factors such as environment, native endowment, diet, psychology Lead to the disorder of body function, so as to cause asthma attack.For chronic asthma, allergic asthma doctor trained in Western medicine at present mainly with hormone It is controlled with aminophylline, side effect is big, without other good methods.Chinese traditional treatment asthma, based on traditional Chinese herbal decoction, be aided with it is middle at Submissive, acupuncture cupping of medicine, Chinese medicine etc., there is apparent advantage, but traditional decoction poor taste, allows people to feel that toxic side effect is big, needs It decocts and takes, patient compliance is poor.
Direct current current iontophoresis is the therapy that physiotherapy is combined with drug therapy, and especially intermediate frequency electro-ionic osmosis is then The new technology developed in recent years.A part of drug is dissociated into ion, straight using in drug solution by direct current current iontophoresis Under the action of galvanic electricity, according to the principle that identical charges repel each other, there is a natural attraction between the sexes, anion and cation are oriented movement, cathode medical fluid In containing positively charged medicine ion is contained in negatively charged medicine ion or anode medical fluid, will be moved to human body direction It moves and enters internal.Since intermediate frequency electro-ionic osmosis is small relative to direct current current iontophoresis skin electrode Benefit Transfer, drug is not By stomach and intestine and liver, but it is directly imported into lesion part, is subcutaneously forming medicine ion heap and slow release, and intermediate frequency arteries and veins It rushes electrotherapy and medicinal treatment and the complex treatment of neural reflex effect is more excellent than the effect of direct current current iontophoresis.
But current intermediate frequency electro-ionic osmosis process only has single asymmetrical wave pulse lead-in mode, still deposits in importing process In skin pricktest polarity effect, and medical fluid and electrode are separation, and effective liposoluble constituent is less in medical fluid used, greatly shadow Therapeutic effect is rung.
Summary of the invention
In order to overcome the deficiencies in the prior art, the invention discloses a kind of transdermal importing electricity of Chinese medicine for treating asthma Pole plate and physiotherapy equipment, with ethanol as solvent, high degree extracts effective Chinese medicine extract, is closed by Chinese medicine extract and electrode Two for one formed electrode plates, a pair of electrodes plate continual alternating in a dosage period receive symmetrical wave physiologic signal and Asymmetrical wave imports signal, drug can be made rapidly and uniformly to imported into subcutaneous deep, has quick, curative effect to the treatment of asthma Good feature provides the New Product that can push domestic and international market to rapidly to solve this chronic disease of asthma, Jin Erwei Traditional Chinese medicine goes further to the world and opens up new field.
It is described that " continual alternating receives symmetrical wave physiologic signal in a dosage period and asymmetrical wave imports letter Number " lead-in mode, be a kind of theoretic strategic structural of the present invention in medium-frequency pulse iontophoretic delivery mode.In i.e. Frequency pulse asymmetrical wave has the subcutaneous function of medicine-inductiveness, but can generate certain skin electrode during importing Change effect, skin pricktest polarity effect can then weaken medicine-inductiveness speed and import volume；Though medium-frequency pulse does not have Cheng Bo By the subcutaneous function of medicine-inductiveness, but medium-frequency pulse has elimination skin pricktest polarity effect to Cheng Bo physical therapy, accelerates part Blood flow and the effect for improving local blood circulation.In this way, in a dosage period internal intermediate frequency pulse pair Cheng Bo physiologic signal in Frequency pulse asymmetrical wave electro-ionic osmosis signal is continual to be alternately present (this alternating can be 0.5 second or several seconds), so that in Frequency pulse asymmetrical wave imports signal in the state of eliminating skin pricktest polarity effect and blood flow velocity is accelerated, by medicine ion Subcutaneous tissue is imported at faster speed, and is spread rapidly, is subcutaneously being formed medicine ion heap, is being led to enhance medicine ion Speed, depth and the concentration entered.
A kind of transdermal iontophoresis electrode plate of Chinese medicine for treating asthma of disclosure of the invention, including with the medical of core bore socket Silicon rubber conductive plate, heater circuit, intermediate-frequency circuit and the Chinese medicine electrode cores for adsorbing Chinese medicine extract, heater circuit and medium frequency electric Road hovers above in medical grade silicon rubber conductive plate and connect with core bore, and heater circuit and intermediate-frequency circuit should not closely medical grade silicon rubbers The edge of conductive plate can reserve at a distance from 0.6-2.6cm, heater circuit and medium frequency electric with the edge of medical grade silicon rubber conductive plate There are many disks to spread mode on road, heater circuit can cured around the surrounding distribution of medical grade silicon rubber conductive plate or by heater circuit With being in corrugated distribution on silicon rubber conductive plate, to facilitate Homogeneouslly-radiating, the Chinese medicine electrode cores for adsorbing Chinese medicine extract are embedding In medical grade silicon rubber conductive plate, the chimeric mode of Chinese medicine electrode cores and medical grade silicon rubber conductive plate can be used medical silicon Rubber conductive plate is surrounded by the flanging inwardly wrapped for installing fixed Chinese medicine electrode cores, naturally it is also possible to pass through its other party Formula is implemented；The Chinese medicine extract is using the Chinese medicine of following parts by weight as raw material: 50-120 parts of caulis piperis futokadsurae, 40-80 parts of ganoderma lucidum, fiber crops 30-80 parts yellow, 30-70 parts of asarum, 30-70 parts of radix scutellariae, 20-50 parts of the tuber of stemona, 20-60 parts of fritillaria thunbergii, 20-50 parts of Exocarpium Citri Rubrum, Cynanchum glaucescens 20-50 parts, 20-55 parts of aster, 15-45 parts of pheretima, 14-30 parts of datura flower, 15-50 parts of ching-chieh, 15-45 parts of radix saposhnikoviae, cicada it is de- 15-50 parts, 20-50 parts of flos caryophylli, 15-45 parts of semen brassicae, 20-50 parts of Herba Epimedii, 15-45 parts of radix aconiti lateralis preparata, 20-45 parts of cortex cinnamomi, 15-40 parts of rhizoma pinellinae praeparata, 15-45 parts of rhizoma anemarrhenae, 20-45 parts of cordate houttuynia, 20-50 parts of Radix Glycyrrhizae, 20-50 parts of spina gleditsiae, with ethanol as solvent It extracts and obtains the Chinese medicine extract that relative density is 0.90-1.18g/mL, the adsorbance of Chinese medicine extract in Chinese medicine electrode cores For 60-135mL/cm3.Wherein, Chinese medicine electrode cores can be made of the preferable material of the adsorptivities such as non-woven fabrics, gauze, Chinese medicine The size of agent electrode cores is corresponding with the size of medical grade silicon rubber conductive plate；In order to which Chinese medicine electrode cores are longer using preceding energy preservation Unused Chinese medicine electrode cores aluminium foil bag etc. can be sealed preservation by the time.
The Chinese medicine extract is prepared by the raw material of following parts by weight as a preferred implementation manner: sea 70-100 parts of wind rattan, 45-65 parts of ganoderma lucidum, 45-65 parts of Chinese ephedra, 44-58 parts of asarum, 45-57 parts of radix scutellariae, 28-40 parts of the tuber of stemona, bulb of thunberg fritillary 32-45 parts female, 30-40 parts of Exocarpium Citri Rubrum, 30-42 parts of Cynanchum glaucescens, 32-45 parts of aster, 25-35 parts of pheretima, 12-25 parts of datura flower, schizonepeta 25-42 parts of fringe, 25-35 parts of radix saposhnikoviae, cicada be 28-40 parts de-, 30-40 parts of flos caryophylli, 25-35 parts of semen brassicae, 30-40 parts of Herba Epimedii, 25-35 parts of radix aconiti lateralis preparata, 27-35 parts of cortex cinnamomi, 23-36 parts of rhizoma pinellinae praeparata, 25-35 parts of rhizoma anemarrhenae, 27-38 parts of cordate houttuynia, Radix Glycyrrhizae 30-40 Part, 25-35 parts of spina gleditsiae.
Preferably, the Chinese medicine extract is prepared by the raw material of following parts by weight: 86 parts of caulis piperis futokadsurae, ganoderma lucidum 58 Part, 57 parts of Chinese ephedra, 52 parts of asarum, 50 parts of radix scutellariae, 35 parts of the tuber of stemona, 38 parts of fritillaria thunbergii, 35 parts of Exocarpium Citri Rubrum, 36 parts of Cynanchum glaucescens, 40 parts of aster, 30 parts of pheretima, 20 parts of datura flower, 34 parts of ching-chieh, 31 parts of radix saposhnikoviae, cicada take off 32 parts, 36 parts of flos caryophylli, 30 parts of semen brassicae, Herba Epimedii 35 parts, 31 parts of radix aconiti lateralis preparata, 30 parts of cortex cinnamomi, 28 parts of rhizoma pinellinae praeparata, 30 parts of rhizoma anemarrhenae, 33 parts of cordate houttuynia, 35 parts of Radix Glycyrrhizae, 40 parts of spina gleditsiae.
The Chinese medicine extract is extracted by alcohol percolation method as a preferred implementation manner, the second The volume by volume concentration of alcohol is 40-75%.
Preferably, also added with penetrating agent water solubility azone in the Chinese medicine extract；Preferably, the water solubility Azone accounts for the 2-5% of Chinese medicine extract volume fraction.
The amount of Chinese medicine extract is 75-118mL/cm in the Chinese medicine electrode cores as a preferred implementation manner,3。
Preferably, the resistance of the medical grade silicon rubber conductive plate≤30 Ω, the Chinese medicine electricity of the absorption Chinese medicine extract The resistance of pole piece≤10 Ω, and the temperature of herbal penetration electrode plate is maintained 38-42 DEG C.
In order to have better therapeutic effect to asthma, the continual alternating of intermediate-frequency circuit receives symmetrical wave physiologic signal Signal is imported with asymmetrical wave.
It is described the invention also discloses a kind of herbal penetration physiotherapy equipment comprising above-mentioned herbal penetration electrode plate Physiotherapy equipment further includes microprocessor, waveform generator, Dose Controller, amplifier, isolator, open circuit overload detection device, key Input and display alarm part and temperature controller, the input terminal of the output end and microprocessor of key input and display alarm part Connection, the output end of microprocessor is connected with the input end of the temperature controller, the output end of temperature controller with Chinese medicine is transdermal gives The input terminal of medicine electrode plate connects, and the output end of microprocessor and the input terminal of waveform generator connect, waveform generator and micro- The output end of processor is connect with the input terminal of Dose Controller respectively, the output end of Dose Controller and the input terminal of amplifier Connection, the output end of amplifier and the input terminal of isolator connect, the output end of isolator and the defeated of overload detection device of opening a way Enter end connection, the output end for overload detection device of opening a way connects with the input terminal of microprocessor and herbal penetration electrode plate respectively It connects；Above-mentioned herbal penetration physiotherapy equipment by software systems to low frequency, ultralow frequency modulation various waveforms (sine wave, square wave, Integrate wave, differential wave, triangular wave etc.), the design to prescription, the time, temperature etc. programming Control.Power supply: power supply has R type transformation Device is depressured network voltage, operating voltage needed for obtaining equipment；Microprocessor: the various movements of equipment are controlled；Waveform occurs Device: waveform needed for generating；Dose Controller: the size of dosage is controlled；Amplifier: signal is amplified；Isolator: isolation electricity Device control section is isolated with human body；Open circuit overload detection device: judge whether pole plate opens a way with whether signal overloads；Chinese medicine is saturating Skin iontophoresis electrode plate: effect with human body and heat；Key input and display alarm part: man-machine dialogue interface.
The characteristics of herbal penetration physiotherapy equipment of the present invention, is: medium-frequency pulse physical therapy, intermediate frequency arteries and veins can be achieved It is punched through skin and imports administration physical therapy and intrinsic heat physical therapy function, physics reason is carried out by the medium-frequency pulse symmetrical wave that low frequency and ultralow frequency are modulated It treats, square wave, the sine wave for the medium-frequency pulse asymmetrical wave modulated by low frequency and ultralow frequency carry out transdermal ion and import administration, and work Working frequency selects the frequency adapted to from seven grades of frequencies of 2kHz, 4kHz, 6kHz, 7kHz, 8kHz, 9kHz, 10kHz, writes software System is controlled by microprocessor, and medium-frequency pulse is made to import signal in a dosage period to Cheng Bo physiologic signal and asymmetrical wave Continual alternating is output to two electrode plates, and the position that effect needs physical therapy to be administered with human body has medicine ion exchange concurrently Cutaneous penetration and the stroke of medium-frequency pulse wave energy improve drug by force and rapidly enter effect that is subcutaneous and spreading, and drug can be made quick Subcutaneous deep uniformly is penetrated into, to achieve the purpose that more efficient subcutaneous administration.
Chinese medicine material and formula in the present invention are the warps that electro-ionic osmosis Chinese medicine external is studied according to theory of traditional Chinese medical science and many years It tests and repeatedly practises screening, medicine prescription is selected with pharmacological property and effect compatibility.Chinese medicine think asthma main cause in phlegm, feature be the cold of insufficiency type and Cold-evil, based on lung deficiency of the kidney void, excess of yin due to yang insufficiency, gas does not change dregs, raw in phlegm retention, meets outer cold-evil's (allergy object, germ), draw promote and Hair.Though asthma is divided into heat heavy breathing of roaring of trembling with fear, in the majority with cold heavy breathing.Asthma is controlled to work as from cold dispelling wind-dispelling, dehumidifying resolving sputum, warm kidney promoting the dispersing function of the lung, stop Cloperastine asthma, promoting blood circulation latus rectum, antiallergic anti-inflammatory are started with.Caulis piperis futokadsurae tepor in side enters Liver Channel, is longer than dispelling wind and removing obstruction in the meridians, and blood circulation and channel invigorating is kind to control Wind-cold-dampness arthralgia, asthma is cold roar it is in the majority, it is first in expelling wind and clearing away cold, caulis piperis futokadsurae can also ventilating, there is special efficacy to asthma chronic cough, Therefore selecting caulis piperis futokadsurae is monarch drug in a prescription.Being equipped with ganoderma lucidum, Chinese ephedra, asarum is ministerial drug, and ganoderma lucidum is to bronchial muscular spasm caused by antihistaminicum Property wheeze, have preferable antibechic, phlegm-dispelling functions, especially ganoderma lucidum can make it is of flaccid muscles, improve microcirculation, can enhance it is transdermal to The effect of medicine.The effect of Chinese ephedra, asarum expelling cold and relieving exterior syndrome, warm kidney mend fire, more enhance warm cold retained fluid and antiasthmatic-antitussive, asarum simultaneously has There is diastole bronchial smooth muscle antiasthmatic effect；The tuber of stemona, rhizoma pinellinae praeparata, Radix Glycyrrhizae, Exocarpium Citri Rubrum, Cynanchum glaucescens, semen brassicae, aster in side have and mend Spleen QI invigorating, warming lung for dispelling cold, it is relieving cough and reducing sputum, wide in sharp gas effect；Flos caryophylli, Herba Epimedii, radix aconiti lateralis preparata, cortex cinnamomi in side have temperature Tonifying spleen kidney, warming kidney and enhancing yang, the effect of warming lung for dispelling cold, eliminating phlegm and relieving cough；Datura flower in side, ching-chieh, radix saposhnikoviae, cicada be de-, asarum, existing Relieving exterior syndrome and dispelling cold, the effect of warming lung and reducing phlegm cough-relieving also have antianaphylactic effect, hyoscine energy expansion bronchus contained by datura flower And inhibits respiratory tract glandular secretion and alleviate the effect of asthma；Radix scutellariae, fritillaria thunbergii, pheretima, rhizoma anemarrhenae, cordate houttuynia in side have clear Hot eliminating dampness, promoting the dispersing function of the lung dissipating bind, preventing phlegm from forming and stopping coughing, activating microcirculation and removing stasis medicinal, the effect of bactericidal antiphlogistic；It with spina gleditsiae is especially efficacy-enhancing ingredient in side.Spina gleditsiae, no It is only capable of promoting circulation of blood promoting the circulation of qi, more there is the kind function drawn, " all medicine uplinks can be drawn, control part of the body cavity above the diaphragm housing the heart and lungs disease ".
Above-mentioned all medicines share, cooperates, and itches chronic cough with good health care to bronchial asthma, allergic asthma, pharynx With rehabilitation effect.Physical therapy is carried out when asthma attack, can antiasthmatic-antitussive, effective Control of asthma；Take treating winter disease in summer, annual dog days It 1 time a day, 60 minutes every time, physical therapy 30 days, in the season of current year or coming year asthma attack, asthma did not reaccessed or has a slight hair Make；If continuous 3 year dog days adhere to physical therapy, the asthma of most asthmatic patients is effectively controlled, does not reaccess.
Detailed description of the invention
Fig. 1 is the main view of the transdermal iontophoresis electrode plate of Chinese medicine.
Fig. 2 is the top view of the transdermal iontophoresis electrode plate of Chinese medicine.
Fig. 3 is partly cut-away's top view of the transdermal iontophoresis electrode plate of Chinese medicine.
Fig. 4 is the cross-sectional view of the line A-A along Fig. 3.
Fig. 5 is the block diagram of the herbal penetration physiotherapy equipment comprising the transdermal iontophoresis electrode plate of Chinese medicine.
In figure: 1. medical grade silicon rubber conductive plates, 2. Chinese medicine electrode cores, 3. flanging, 4. sockets, 5. core bore, 6. heating electricity Road, 7. intermediate-frequency circuits.
Specific embodiment
It is described below for disclosing the present invention so that those skilled in the art can be realized the present invention.It is excellent in being described below Embodiment is selected to be only used as illustrating, it may occur to persons skilled in the art that other obvious modifications.
Embodiment 1.
A kind of transdermal iontophoresis electrode plate of Chinese medicine for treating asthma, including the medical grade silicon rubber conductive plate with 5 socket 4 of core bore 1, heater circuit, intermediate-frequency circuit and the Chinese medicine electrode cores 2 for adsorbing Chinese medicine extract, heater circuit 6 and intermediate-frequency circuit 7 hover above It is connect in medical grade silicon rubber conductive plate 1 and with core bore 5, medical grade silicon rubber conductive plate 1 has inside for fixing Chinese medicine electrode cores 2 The flanging 3 of packet, is entrenched in Chinese medicine electrode cores 2 in medical grade silicon rubber conductive plate 1；The Chinese medicine extract is with following weight The Chinese medicine of part is raw material: 50 parts of caulis piperis futokadsurae, 40 parts of ganoderma lucidum, 30 parts of Chinese ephedra, 30 parts of asarum, 70 parts of radix scutellariae, 50 parts of the tuber of stemona, fritillaria thunbergii 60 parts, 20 parts of Exocarpium Citri Rubrum, 20 parts of Cynanchum glaucescens, 20 parts of aster, 15 parts of pheretima, 10 parts of datura flower, 15 parts of ching-chieh, 15 parts of radix saposhnikoviae, cicada it is de- 15 parts, 20 parts of flos caryophylli, 15 parts of semen brassicae, 20 parts of Herba Epimedii, 15 parts of radix aconiti lateralis preparata, 20 parts of cortex cinnamomi, 15 parts of rhizoma pinellinae praeparata, rhizoma anemarrhenae 15 Part, 20 parts of cordate houttuynia, 20 parts of Radix Glycyrrhizae, 20 parts of spina gleditsiae, the ethanol as solvent for being 75% with volume by volume concentration, are extracted by percolation, It is clarified, the Chinese medicine extract that relative density is 0.90g/mL is obtained after filtering, then be added into Chinese medicine extract and account for Chinese medicine and mention The water-soluble azone penetrating agent that the volume fraction of liquid is 2% is taken, the adsorbance of Chinese medicine extract is in Chinese medicine electrode cores 133mL/cm3, the resistance of medical grade silicon rubber conductive plate is 28-30 Ω, the Chinese medicine electrode cores of the absorption Chinese medicine extract Resistance is 9-10 Ω, and the temperature of herbal penetration electrode plate is maintained 38-42 DEG C.
Embodiment 2.
A kind of transdermal iontophoresis electrode plate of Chinese medicine for treating asthma, including the medical grade silicon rubber conductive plate with 5 socket 4 of core bore 1, heater circuit, intermediate-frequency circuit and the Chinese medicine electrode cores 2 for adsorbing Chinese medicine extract, heater circuit 6 and intermediate-frequency circuit 7 hover above It is connect in medical grade silicon rubber conductive plate 1 and with core bore 5, medical grade silicon rubber conductive plate 1 has inside for fixing Chinese medicine electrode cores 2 The flanging 3 of packet, is entrenched in Chinese medicine electrode cores 2 in medical grade silicon rubber conductive plate 1；The Chinese medicine extract is with following weight The Chinese medicine of part is raw material: 120 parts of caulis piperis futokadsurae, 80 parts of ganoderma lucidum, 80 parts of Chinese ephedra, 70 parts of asarum, 30 parts of radix scutellariae, 20 parts of the tuber of stemona, bulb of thunberg fritillary Female 20 parts, 50 parts of Exocarpium Citri Rubrum, 50 parts of Cynanchum glaucescens, 55 parts of aster, 45 parts of pheretima, 18 parts of datura flower, 50 parts of ching-chieh, windproof 45 parts, cicada Take off 50 parts, 50 parts of flos caryophylli, 45 parts of semen brassicae, 50 parts of Herba Epimedii, 45 parts of radix aconiti lateralis preparata, 45 parts of cortex cinnamomi, 40 parts of rhizoma pinellinae praeparata, rhizoma anemarrhenae 45 Part, 45 parts of cordate houttuynia, 50 parts of Radix Glycyrrhizae, 50 parts of spina gleditsiae, the ethanol as solvent for being 40% with volume by volume concentration, are extracted by percolation, It is clarified, the Chinese medicine extract that relative density is 1.18g/mL is obtained after filtering, then be added into Chinese medicine extract and account for Chinese medicine and mention The water-soluble azone penetrating agent that the volume fraction of liquid is 3% is taken, the adsorbance of Chinese medicine extract is in Chinese medicine electrode cores 132mL/cm3, the resistance of medical grade silicon rubber conductive plate is 24-27 Ω, the Chinese medicine electrode cores of the absorption Chinese medicine extract Resistance is 7-8 Ω, and the temperature of herbal penetration electrode plate is maintained 39-40 DEG C.
Embodiment 3.
A kind of transdermal iontophoresis electrode plate of Chinese medicine for treating asthma, including the medical grade silicon rubber conductive plate with 5 socket 4 of core bore 1, heater circuit, intermediate-frequency circuit and the Chinese medicine electrode cores 2 for adsorbing Chinese medicine extract, heater circuit 6 and intermediate-frequency circuit 7 hover above It is connect in medical grade silicon rubber conductive plate 1 and with core bore 5, medical grade silicon rubber conductive plate 1 has inside for fixing Chinese medicine electrode cores 2 The flanging 3 of packet, is entrenched in Chinese medicine electrode cores 2 in medical grade silicon rubber conductive plate 1；The Chinese medicine extract is with following weight The Chinese medicine of part is raw material: 70 parts of caulis piperis futokadsurae, 52 parts of ganoderma lucidum, 45 parts of Chinese ephedra, 44 parts of asarum, 45 parts of radix scutellariae, 28 parts of the tuber of stemona, fritillaria thunbergii 32 parts, 30 parts of Exocarpium Citri Rubrum, 30 parts of Cynanchum glaucescens, 32 parts of aster, 25 parts of pheretima, 30 parts of datura flower, 25 parts of ching-chieh, 25 parts of radix saposhnikoviae, cicada it is de- 28 parts, 30 parts of flos caryophylli, 25 parts of semen brassicae, 30 parts of Herba Epimedii, 25 parts of radix aconiti lateralis preparata, 27 parts of cortex cinnamomi, 23 parts of rhizoma pinellinae praeparata, rhizoma anemarrhenae 25 Part, 27 parts of cordate houttuynia, 30 parts of Radix Glycyrrhizae, 38 parts of spina gleditsiae, the ethanol as solvent for being 50% with volume by volume concentration, are extracted by percolation, It is clarified, the Chinese medicine extract that relative density is 1.12g/mL is obtained after filtering, then be added into Chinese medicine extract and account for Chinese medicine and mention The water-soluble azone penetrating agent that the volume fraction of liquid is 2% is taken, the adsorbance of Chinese medicine extract is in Chinese medicine electrode cores 73mL/cm3, the resistance of medical grade silicon rubber conductive plate is 26-29 Ω, the electricity of the Chinese medicine electrode cores of the absorption Chinese medicine extract Resistance is 6-8 Ω, and the temperature of herbal penetration electrode plate is maintained 38-40 DEG C.
Embodiment 4.
A kind of transdermal iontophoresis electrode plate of Chinese medicine for treating asthma, including the medical grade silicon rubber conductive plate with 5 socket 4 of core bore 1, heater circuit, intermediate-frequency circuit and the Chinese medicine electrode cores 2 for adsorbing Chinese medicine extract, heater circuit 6 and intermediate-frequency circuit 7 hover above It is connect in medical grade silicon rubber conductive plate 1 and with core bore 5, medical grade silicon rubber conductive plate 1 has inside for fixing Chinese medicine electrode cores 2 The flanging 3 of packet, is entrenched in Chinese medicine electrode cores 2 in medical grade silicon rubber conductive plate 1；The Chinese medicine extract is with following weight The Chinese medicine of part is raw material: 100 parts of caulis piperis futokadsurae, 70 parts of ganoderma lucidum, 65 parts of Chinese ephedra, 58 parts of asarum, 57 parts of radix scutellariae, 40 parts of the tuber of stemona, bulb of thunberg fritillary Female 45 parts, 40 parts of Exocarpium Citri Rubrum, 42 parts of Cynanchum glaucescens, 45 parts of aster, 35 parts of pheretima, 26 parts of datura flower, 42 parts of ching-chieh, windproof 35 parts, cicada Take off 40 parts, 40 parts of flos caryophylli, 35 parts of semen brassicae, 40 parts of Herba Epimedii, 35 parts of radix aconiti lateralis preparata, 35 parts of cortex cinnamomi, 36 parts of rhizoma pinellinae praeparata, rhizoma anemarrhenae 35 Part, 38 parts of cordate houttuynia, 40 parts of Radix Glycyrrhizae, 42 parts of spina gleditsiae, the ethanol as solvent for being 68% with volume by volume concentration, are extracted by percolation, It is clarified, the Chinese medicine extract that relative density is 0.98g/mL is obtained after filtering, then be added into Chinese medicine extract and account for Chinese medicine and mention The water-soluble azone penetrating agent that the volume fraction of liquid is 3% is taken, the adsorbance of Chinese medicine extract is in Chinese medicine electrode cores 115mL/cm3, the resistance of medical grade silicon rubber conductive plate is 24-28 Ω, the Chinese medicine electrode cores of the absorption Chinese medicine extract Resistance is 8-10 Ω, and the temperature of herbal penetration electrode plate is maintained 38-42 DEG C.
Embodiment 5.
A kind of transdermal iontophoresis electrode plate of Chinese medicine for treating asthma, including the medical grade silicon rubber conductive plate with 5 socket 4 of core bore 1, heater circuit, intermediate-frequency circuit and the Chinese medicine electrode cores 2 for adsorbing Chinese medicine extract, heater circuit 6 and intermediate-frequency circuit 7 hover above It is connect in medical grade silicon rubber conductive plate 1 and with core bore 5, medical grade silicon rubber conductive plate 1 has inside for fixing Chinese medicine electrode cores 2 The flanging 3 of packet, is entrenched in Chinese medicine electrode cores 2 in medical grade silicon rubber conductive plate 1；The Chinese medicine extract is with following weight The Chinese medicine of part is raw material: 86 parts of caulis piperis futokadsurae, 55 parts of ganoderma lucidum, 57 parts of Chinese ephedra, 52 parts of asarum, 50 parts of radix scutellariae, 35 parts of the tuber of stemona, fritillaria thunbergii 38 parts, 35 parts of Exocarpium Citri Rubrum, 36 parts of Cynanchum glaucescens, 40 parts of aster, 21 parts of datura flower, 30 parts of pheretima, 34 parts of ching-chieh, 31 parts of radix saposhnikoviae, cicada are de- 32 parts, 36 parts of flos caryophylli, 30 parts of semen brassicae, 35 parts of Herba Epimedii, 31 parts of radix aconiti lateralis preparata, 30 parts of cortex cinnamomi, 28 parts of rhizoma pinellinae praeparata, rhizoma anemarrhenae 30 Part, 33 parts of cordate houttuynia, 35 parts of Radix Glycyrrhizae, 33 parts of spina gleditsiae, the ethanol as solvent for being 60% with volume by volume concentration is extracted by percolation, It is clarified, the Chinese medicine extract that relative density is 1.07g/mL is obtained after filtering, then be added into Chinese medicine extract and account for Chinese medicine and mention The water-soluble azone penetrating agent that the volume fraction of liquid is 5% is taken, the adsorbance of Chinese medicine extract is in Chinese medicine electrode cores 92mL/cm3, the resistance of medical grade silicon rubber conductive plate is 27-29 Ω, the electricity of the Chinese medicine electrode cores of the absorption Chinese medicine extract Resistance is 8-9 Ω, and the temperature of herbal penetration electrode plate is maintained 37-40 DEG C.
Use the herbal penetration physical therapy of the transdermal iontophoresis electrode plate of the Chinese medicine for the treatment asthma for including above-described embodiment 1 Instrument treats bronchial asthma, allergic asthma, pharynx cough of itching.The World Health Organization is determined as asthma to control all the life The property treated effect disease, therefore, effectively control and alleviation asthma attack are the key that treatment asthma.Following efficacy determination is taken in this physical therapy Standard: A. clinic control, clinical symptoms, sign disappear or mostly disappear；B. effective, clinical symptoms, sign are obviously improved；C. have Effect, clinical symptoms, sign take a favorable turn；D. invalid, clinical symptoms, sign are without improvement, even it aggravates or midway stopping person.
First kind curative effect: i.e. asthma attack, chill pharynx, which are itched, carries out physical therapy when causing cough and asthma breaking-out, and electrode is placed in the bottom of heart Cave and DINGCHUAN acupoint, each the transdermal importing of Chinese medicine 60 minutes, 1 time a day, and each course for the treatment of 10 days, each course for the treatment of midfeather 3 days.It sees Examining 38, wherein bronchial asthma and allergic asthma 22, chill pharynx, which is itched, causes cough and asthma 16, male 20, and female 18, year Age 21-66 years old, course of disease 1-50.Clinic control 14, account for 37%；Effective 18, account for 47%；Effective 3, account for 8%；It invalid 3, accounts for 8%, concrete outcome is as shown in table 1.
Second class curative effect: i.e. asthma treating winter disease in summer, annual dog days in summer do 3 courses for the treatment of, and electrode is placed in the bottom of heart cave And DINGCHUAN acupoint, each the transdermal importing of Chinese medicine 60 minutes, 1 time a day, each course for the treatment of 10 days, each course for the treatment of midfeather 3 days, continuously It does 3 years.Physical therapy observes asthma 29, wherein male 13, female 16, and the age, 20-68 years old, course of disease 3-55.Clinic control 11 Example, accounts for 38%, i.e., morbidity season is not fallen ill in patient's physical therapy 1 year；Effective 13,45% is accounted for, i.e., is fallen ill in patient's physical therapy 1 year Season does not fall ill or disease time is short and can voluntarily alleviate；Effective 3,10% is accounted for, i.e., occasionally has morbidity in patient's physical therapy 1 year, But number of incidences is significantly lower than number of incidences before physical therapy；Invalid 2,7% is accounted for, i.e., incidence and reason in patient's physical therapy 1 year Slightly improve before treating, but difference is little, concrete outcome is as shown in table 2.
The result of 1 first kind curative effect of table.
The result of 2 second class curative effect of table.
The basic principles, main features and advantages of the present invention have been shown and described above.The technology of the industry Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and what is described in the above embodiment and the description is only the present invention Principle, various changes and improvements may be made to the invention without departing from the spirit and scope of the present invention, these variation and Improvement is both fallen in the range of claimed invention.The present invention claims protection scope by appended claims and its Equivalent defines.

Claims (9)

1. a kind of transdermal iontophoresis electrode plate of Chinese medicine for treating asthma, including with core bore socket medical grade silicon rubber conductive plate plus Heater circuit, intermediate-frequency circuit and the Chinese medicine electrode cores for adsorbing Chinese medicine extract, heater circuit and intermediate-frequency circuit hover above medical silicon It is connect in rubber conductive plate and with core bore, and the edge of heater circuit and intermediate-frequency circuit and medical grade silicon rubber conductive plate reserves 0.6- The distance of 2.6cm leads heater circuit around the surrounding distribution of medical grade silicon rubber conductive plate or by heater circuit in medical grade silicon rubber It is in corrugated distribution on battery plate, to facilitate Homogeneouslly-radiating, adsorbs the Chinese medicine electrode cores of Chinese medicine extract embedded in medical silicon rubber In glue conductive plate；Medical grade silicon rubber conductive plate is surrounded by the flanging for being used to install fixed Chinese medicine electrode cores and inwardly wrapping； The Chinese medicine extract is using the Chinese medicine of following parts by weight as raw material: 50-120 parts of caulis piperis futokadsurae, 40-80 parts of ganoderma lucidum, Chinese ephedra 30-80 Part, 30-70 parts of asarum, 30-70 parts of radix scutellariae, 20-50 parts of the tuber of stemona, 20-60 parts of fritillaria thunbergii, 20-50 parts of Exocarpium Citri Rubrum, 20-50 parts of Cynanchum glaucescens, 20-55 parts of aster, 15-45 parts of pheretima, 10-30 parts of datura flower, 15-50 parts of ching-chieh, 15-45 parts of radix saposhnikoviae, cicada be 15-50 parts de-, 20-50 parts of flos caryophylli, 15-45 parts of semen brassicae, 20-50 parts of Herba Epimedii, 15-45 parts of radix aconiti lateralis preparata, 20-45 parts of cortex cinnamomi, rhizoma pinellinae praeparata 15- 40 parts, 15-45 parts of rhizoma anemarrhenae, 20-45 parts of cordate houttuynia, 20-50 parts of Radix Glycyrrhizae, 20-50 parts of spina gleditsiae, extract to obtain phase with ethanol as solvent It is the Chinese medicine extract of 0.90-1.18g/mL to density, the adsorbance of Chinese medicine extract is 60-135mL/ in Chinese medicine electrode cores cm3；The intermediate-frequency circuit is continual alternately to receive symmetrical wave physiologic signal and asymmetrical wave pulse signal, by low frequency and ultralow The medium-frequency pulse symmetrical wave of frequency modulation carries out physical therapy, by the side for the medium-frequency pulse asymmetrical wave that low frequency and ultralow frequency are modulated Wave, sine wave carry out transdermal ion and import administration, and working frequency is from 2kHz, 4kHz, 6kHz, 7kHz, 8kHz, 9kHz, 10kHz Selected in seven grades of frequencies adapt to frequency so that medium-frequency pulse asymmetrical wave import signal eliminate skin pricktest polarity effect and In the state that blood flow velocity is accelerated, medicine ion is imported into subcutaneous tissue, and spread rapidly at faster speed, subcutaneously formed Medicine ion heap, to enhance the speed of medicine-inductiveness, depth and concentration.
2. the transdermal iontophoresis electrode plate of Chinese medicine for the treatment of asthma as described in claim 1, which is characterized in that the Chinese medicine extract It is to be prepared by the raw material of following parts by weight: 70-100 parts of caulis piperis futokadsurae, 45-65 parts of ganoderma lucidum, 45-65 parts of Chinese ephedra, asarum 44- 58 parts, 45-57 parts of radix scutellariae, 28-40 parts of the tuber of stemona, 32-45 parts of fritillaria thunbergii, 30-40 parts of Exocarpium Citri Rubrum, 30-42 parts of Cynanchum glaucescens, aster 32-45 Part, 25-35 parts of pheretima, 12-25 parts of datura flower, 25-42 parts of ching-chieh, 25-35 parts of radix saposhnikoviae, cicada take off 28-40 parts, flos caryophylli 30- 40 parts, 25-35 parts of semen brassicae, 30-40 parts of Herba Epimedii, 25-35 parts of radix aconiti lateralis preparata, 27-35 parts of cortex cinnamomi, 23-36 parts of rhizoma pinellinae praeparata, rhizoma anemarrhenae 25-35 parts, 27-38 parts of cordate houttuynia, 30-40 parts of Radix Glycyrrhizae, 25-35 parts of spina gleditsiae.
3. the transdermal iontophoresis electrode plate of Chinese medicine for the treatment of asthma as claimed in claim 2, which is characterized in that the Chinese medicine extract It is to be prepared by the raw material of following parts by weight: 86 parts of caulis piperis futokadsurae, 58 parts of ganoderma lucidum, 57 parts of Chinese ephedra, 52 parts of asarum, radix scutellariae 50 Part, 35 parts of the tuber of stemona, 38 parts of fritillaria thunbergii, 35 parts of Exocarpium Citri Rubrum, 36 parts of Cynanchum glaucescens, 40 parts of aster, 30 parts of pheretima, 20 parts of datura flower, ching-chieh 34 parts, 31 parts of radix saposhnikoviae, cicada be 32 parts de-, 36 parts of flos caryophylli, 30 parts of semen brassicae, 35 parts of Herba Epimedii, 31 parts of radix aconiti lateralis preparata, 30 parts of cortex cinnamomi, 28 parts of rhizoma pinellinae praeparata, 30 parts of rhizoma anemarrhenae, 33 parts of cordate houttuynia, 35 parts of Radix Glycyrrhizae, 40 parts of spina gleditsiae.
4. the transdermal iontophoresis electrode plate of Chinese medicine for the treatment of asthma as described in claim 1, it is characterised in that: the Chinese medicine extract It is to be extracted by alcohol percolation method, the volume by volume concentration of the ethyl alcohol is 40-75%.
5. the transdermal iontophoresis electrode plate of the Chinese medicine of the treatment asthma as described in any in claim 1-4, it is characterised in that: described Also added with penetrating agent water solubility azone in Chinese medicine extract.
6. the transdermal iontophoresis electrode plate of Chinese medicine for the treatment of asthma as claimed in claim 5, it is characterised in that: the water solubility laurel The volume fraction that azone accounts for Chinese medicine extract is 2-5%.
7. the transdermal iontophoresis electrode plate of Chinese medicine for the treatment of asthma as claimed in claim 6, it is characterised in that: the Chinese medicine electrode The amount of Chinese medicine extract is 75-118mL/cm in core3。
8. the transdermal iontophoresis electrode plate of Chinese medicine for the treatment of asthma as claimed in claim 7, it is characterised in that: the medical grade silicon rubber is led The resistance of battery plate≤30 Ω, resistance≤10 Ω of the Chinese medicine electrode cores.
9. a kind of herbal penetration physiotherapy equipment, it is characterised in that including treatment asthma such as described in any one of claims 1-8 The transdermal iontophoresis electrode plate of Chinese medicine, further include microprocessor, waveform generator, Dose Controller, amplifier, isolator, open circuit The output end of overload detection device, key input and display alarm part and temperature controller, key input and display alarm part with The input terminal of microprocessor connects, and the output end of microprocessor is connected with the input end of the temperature controller, temperature controller it is defeated Outlet is connect with the input terminal of herbal penetration electrode plate, and the output end of microprocessor and the input terminal of waveform generator connect It connects, the output end of waveform generator and microprocessor is connect with the input terminal of Dose Controller respectively, the output of Dose Controller End connect with the input terminal of amplifier, the connection of the input terminal of the output end and isolator of amplifier, the output end of isolator and The input terminal connection of open circuit overload detection device, the output end for overload detection device of opening a way are transdermal with microprocessor and Chinese medicine respectively The input terminal connection of electrode plate is administered.
CN201610062736.0A 2016-01-29 2016-01-29 A kind of transdermal iontophoresis electrode plate of Chinese medicine and physiotherapy equipment for treating asthma Active CN105727434B (en)

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Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN2068838U (en) * 1989-07-16 1991-01-09 天津市现代保健品应用技术研究所 Electric medicine-moxibustion therapeutic apparatus
CN1157736A (en) * 1996-12-30 1997-08-27 赵建立 Special medications ticking sheet dispensing for pneumonia therapeutic equipment and production technology
CN1357394A (en) * 2000-12-14 2002-07-10 上海大学 Chinese medicine acupoint introducing method and device
CN1698914A (en) * 2005-06-08 2005-11-23 山西怡生堂医疗技术有限公司 Method for treating cervical vertebra or lumbar vertebra disease by computer digital controlled medium-frequency wave and therapeutic device thereof
CN1840122A (en) * 2006-01-23 2006-10-04 广西金页制药有限公司 Chinese medicinal preparation for stopping cough and resolving phlegm and preparation method thereof
CN2875484Y (en) * 2006-02-24 2007-03-07 山西怡生堂医疗技术有限公司 Temp. control conducting polar plate
CN2877758Y (en) * 2005-06-08 2007-03-14 山西怡生堂医疗技术有限公司 Computer digital control intermediate frequency therapeutic instrument for cervical spondylopathy

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN2068838U (en) * 1989-07-16 1991-01-09 天津市现代保健品应用技术研究所 Electric medicine-moxibustion therapeutic apparatus
CN1157736A (en) * 1996-12-30 1997-08-27 赵建立 Special medications ticking sheet dispensing for pneumonia therapeutic equipment and production technology
CN1357394A (en) * 2000-12-14 2002-07-10 上海大学 Chinese medicine acupoint introducing method and device
CN1698914A (en) * 2005-06-08 2005-11-23 山西怡生堂医疗技术有限公司 Method for treating cervical vertebra or lumbar vertebra disease by computer digital controlled medium-frequency wave and therapeutic device thereof
CN2877758Y (en) * 2005-06-08 2007-03-14 山西怡生堂医疗技术有限公司 Computer digital control intermediate frequency therapeutic instrument for cervical spondylopathy
CN1840122A (en) * 2006-01-23 2006-10-04 广西金页制药有限公司 Chinese medicinal preparation for stopping cough and resolving phlegm and preparation method thereof
CN2875484Y (en) * 2006-02-24 2007-03-07 山西怡生堂医疗技术有限公司 Temp. control conducting polar plate

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