CN105727272A - Veterinary drug for treating cow infertility - Google Patents

Veterinary drug for treating cow infertility Download PDF

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Publication number
CN105727272A
CN105727272A CN201610279528.6A CN201610279528A CN105727272A CN 105727272 A CN105727272 A CN 105727272A CN 201610279528 A CN201610279528 A CN 201610279528A CN 105727272 A CN105727272 A CN 105727272A
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weight portion
radix
weight
preparation
enzyme preparation
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姚四新
赵淑秋
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Henan Institute of Science and Technology
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Henan Institute of Science and Technology
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • A61K36/076Poria
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
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    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282Artemisia, e.g. wormwood or sagebrush
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    • A61K36/185Magnoliopsida (dicotyledons)
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    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287Chrysanthemum, e.g. daisy
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    • A61K36/39Convolvulaceae (Morning-glory family), e.g. bindweed
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    • A61K36/484Glycyrrhiza (licorice)
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    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537Salvia (sage)
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    • A61K36/65Paeoniaceae (Peony family), e.g. Chinese peony
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    • A61K36/68Plantaginaceae (Plantain Family)
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    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734Crataegus (hawthorn)
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Abstract

The invention discloses a veterinary drug for treating cow infertility. The scheme comprises the following steps: (1) selecting poria cocos, plantain herb, serissa japonica, angelica sinensis, salvia miltiorrhiza, dipsacus asperoides, flatstem milkvetch seeds, semen cuscutae, flos chrysanthemi, rhizoma cyperi, lycium barbarum, radix astragali, rhizoma atractylodis macrocephalae, radix angelicae, rhizoma dioscoreae, radix paeoniae alba, charred fructus crataegi, liquorice, a micro-ecological preparation and an enzyme preparation; and (2) adding the Chinese herbal medicines into a pulverizer and processing into powder with particle size of 30-200 meshes; sieving; adding 0.5 part by weight of micro-ecological preparation and 0.05 part by weight of enzyme preparation and mixing uniformly; and finally, granulating to finish the preparation. The veterinary drug disclosed by the invention conforms to the industrial policy of national veterinary drug development, meets the requirement for production of pollution-free food without antibiotic residue, and meets the requirements for developing scientific and technological enterprises and enhancing the innovation ability of the enterprises.

Description

A kind of veterinary drug treating barrenness of milk cow
Technical field:
The present invention relates to veterinary drug, a kind of veterinary drug treating barrenness of milk cow.
Background technology:
Barrenness of milk cow refers to do not have the cattle of pregnancy through 3 breedings, is a kind of phenomenon most commonly seen in milk cows, its reason Including (1) feeding and management factor and the nutritional imbalance of feedstuff, be most commonly that vitamin (shortage of especially VA and VE) and Mineral (calcium phosphorus etc.) and the shortage of trace element (such as copper, ferrum, zinc, manganese);(2) urogenital tract infection;(3) endocrine disturbance leads Cause reproductive system disease (mainly hypo ovaria, ovarian cyst, retained corpus luteum etc.).This disease greatly have impact on milch cow Fertility, significantly reduces the economic benefit of foster milch cow.The conventional therapy of primary disease causes using in a large number hormone and antibiotic etc., Its consequence is that the drug resistance phenomenon of antibiotic is more prevalent, and curative effect reduces, animal product Quality Down.For avoiding sending out of above-mentioned phenomenon Life the invention provides a kind of drug resistance that do not produces does not affects the veterinary drug treating barrenness of milk cow of milch cow product quality.
Summary of the invention:
It is an object of the invention to provide one can overcome milch cow to cause drug resistance because being excessively used antibiotic and hormone medicine for a long time Property bacterial strain generation, avoid medicine through use after in Contents in Cows remain, strengthen milch cow body immunity, improve milch cow life Produce performance, significantly improve the veterinary drug of the treatment barrenness of milk cow of milk beef dairy products quality simultaneously.
The technical scheme is that, a kind of veterinary drug treating barrenness of milk cow, it is characterised in that:
Poria 15-30 weight portion, Herba Plantaginis 12-30 weight portion, Serissa foetida 8-15 weight portion, Radix Angelicae Sinensis 8-15 weight portion, Radix Salviae Miltiorrhizae 7-15 weight portion, Radix Dipsaci 7-15 weight portion, Semen Astragali Complanati 7-15 weight portion, Semen Cuscutae 7-15 weight portion, Flos Chrysanthemi 5-10 weight portion, Rhizoma Cyperi 5-15 weight portion, Fructus Lycii 5-12 weight portion, Radix Astragali 8-20 weight portion, Rhizoma Atractylodis Macrocephalae 6-12 weight portion, Radix Angelicae Dahuricae 5-10 weight portion, Rhizoma Dioscoreae 16-30 weight portion, Radix Paeoniae Alba 5-12 weight portion, Fructus Crataegi (parched to brown) 5-15 weight portion, Radix Glycyrrhizae 1-3 weight portion, microbial ecological agent 0.2- 0.5 weight portion, enzyme preparation 0.02-0.05 weight portion;(2) when preparing, each composition Chinese herbal medicine is added in pulverizer and be processed into 30- The powder of 200 mesh, sieves, rear microbial ecological agent 0.5 weight portion, enzyme preparation 0.05 weight portion of adding, then mix homogeneously, finally Pelletize, complete preparation.
The preferred preparation technology of the present invention is: (1) Poria 30 weight portion, Herba Plantaginis 30 weight portion, Serissa foetida 15 weight Part, Radix Angelicae Sinensis 15 weight portion, Radix Salviae Miltiorrhizae 15 weight portion, Radix Dipsaci 15 weight portion, Semen Astragali Complanati 15 weight portion, Semen Cuscutae 15 weight portion, chrysanthemum Spend 10 weight portions, Rhizoma Cyperi 15 weight portion, Fructus Lycii 12 weight portion, the Radix Astragali 20 weight portion, the Rhizoma Atractylodis Macrocephalae 12 weight portion, the Radix Angelicae Dahuricae 10 weight portion, Rhizoma Dioscoreae 30 weight portion, the Radix Paeoniae Alba 12 weight portion, Fructus Crataegi (parched to brown) 15 weight portion, Radix Glycyrrhizae 3 weight portion, microbial ecological agent 0.5 weight portion, enzyme Preparation 0.05 weight portion;(2) when preparing, each composition Chinese herbal medicine is added the powder being processed into 30-200 mesh in pulverizer, sieves, Rear addition microbial ecological agent 0.5 weight portion, enzyme preparation 0.05 weight portion, then mix homogeneously, finally pelletize, complete system Standby.
The present invention has a promoting diuresis to eliminate damp pathogen, activating blood circulation to dissipate blood stasis, invigorating spleen to remove dampness, and soothing liver-QI is invigorated blood circulation, the liver and the kidney tonifying, dissipates wind heat clearing away, the kidney invigorating Adjusting blood, dispersing the stagnated live-QI to relieve the stagnation of QI, menstruction regulating and pain relieving, regulate the flow of vital energy in tune, invigorating QI to consolidate the body surface resistance, diuresis poison holding, invigorating the spleen and benefiting QI, hidroschesis is antiabortive, dispels the wind dry Wet, reducing swelling and alleviating pain, convergence is solid de-, heat-clearing and toxic substances removing, soothing the liver dispelling the stagnated QI, and removing food stagnancyization is stagnant, strengthening the spleen stomach function regulating, nourishing blood for regulating menstruation, and yin fluid astringing is only Antiperspirant, clearing away heat and promoting diuresis, the effect of eliminating dampness by diuresis antidiarrheal, there is adjustment flora simultaneously, the feature such as have no side effect, and processing technique is simple Single, production cost is low, effectively reduces milch cow incidence of infertility, enhances the immunity of milch cow body, have adjusted the intestinal microbial population of milch cow, Effectively prevent generation and hormone, the antibiotic residual in Contents in Cows of Resistant strain, improve the product of milk and beef Quality, reduces environmental pollution.
The present invention has the following advantages simultaneously:
1, meet the industrial policy of national basic veterinary drug exploitation, meet and produce nuisanceless, antibiotic-free residual, the wanting of pollution-free food Ask.Meet development scientific and technological enterprises and strengthen the requirement of Enterprise Innovation Capability.
2, do not produce the drug resistance problems that prior art generally exists.
3, owing to the present invention is to be mainly composed of Chinese medicine, and by natural plants and a small amount of microbial ecological agent and enzyme preparation group Becoming, medicine is not the most existed to toxicity problem, produce toxic side effects thus without to milch cow, this point is correlated with The proof of test.
4, the results showed that the medicine character of the present invention and efficacy stability and storage tolerance also are adapted for long-distance and adverse circumstances Transport, this uses beyond doubt the most extremely advantageous for medicine.
Detailed description of the invention:
Describe embodiment in detail,
Embodiment 1
Take Poria 30kg, Herba Plantaginis 30kg, Serissa foetida 15 kg, Radix Angelicae Sinensis 15kg, Radix Salviae Miltiorrhizae 15kg, Radix Dipsaci 15kg, Semen Astragali Complanati 15kg, Semen Cuscutae 15kg, Flos Chrysanthemi 10kg, Rhizoma Cyperi 15kg, Fructus Lycii 12kg, Radix Astragali 20kg, Rhizoma Atractylodis Macrocephalae 12kg, Radix Angelicae Dahuricae 10kg, Rhizoma Dioscoreae 30kg, Radix Paeoniae Alba 12kg, Fructus Crataegi (parched to brown) 15kg, Radix Glycyrrhizae 3kg, microbial ecological agent 0.5kg, enzyme preparation 0.05 kg.
Described microbial ecological agent is that the cattle and sheep tailored version that Beijing Tian Feng Ying Tai Bioisystech Co., Ltd produces is combined micro- Ecological agent: Wei Er strengthens WSR-01, and main component includes enterococcus faecalis, Lactobacillus plantarum, bacillus subtilis, lichens spore bar Bacterium, enzyme preparation, antibacterial peptide (patent) etc., total viable count >=2,000,000,000 cfu/g.On the one hand this product can effectively suppress pathogenic bacterium to exist Field planting in intestinal walls, produces the bioactive substance having inhibitory action to pathogenic bacterium, on the other hand can produce organic acid, stable Ruminal pH value, stimulates rumen microorganism growth, and the decomposition improving feedstuff absorbs, the flora of decomposition of cellulose in significant stimulation cud With the propagation that lactic acid utilizes bacterium, the digestion increasing promotion cellulose of cellulose-decomposing bacterium, bacillus subtilis, lichens spore bar Bacterium produces protease, amylase, improves efficiency of feed utilization, improves the immune function of milch cow, sets up optimum the following of Contents in Cows health Ring, reduces the infertility induced because of raising dairy cattle mismanagement.
Described enzyme preparation is to build the Hylotelephium erythrostictum (Miq.) H.Ohba prestige 2X powder that bright industry (Zhuhai) company limited produces, by α-amylase, wood Dextranase, cellulase, protease, 1,4 beta-glucanase, pectase, amylopectase form, can be by phase by enzyme hydrolysis effect Protein, starch and the non-starch polysaccharides(nsp) answered is hydrolyzed to oligopeptide, aminoacid, oligosaccharide, oligosaccharide and monosaccharide, promotes that milch cow is to accordingly Digesting and assimilating of protein and polysaccharide, improves the feed digestibility of milch cow, improves milk cow production performance, supplements the endogenous of milch cow Enzyme, it is thus achieved that higher rate of return on investment.
Now each composition Chinese herbal medicine is added during preparation the powder being processed into 60 mesh in pulverizer, sieves, add Tiny ecosystem afterwards Preparation: 0.5kg, enzyme preparation: 0.05kg, then mix homogeneously, finally pelletize, packaging, saves backup.
This product, according to listing terms of packing, in temperature 40 DEG C ± 2 DEG C, is deposited under the conditions of relative humidity 75% ± 5% 3 months, Quality, without significant change, in temperature 25 DEG C ± 2 DEG C, is deposited under the conditions of relative humidity 60% ± 10% 22 months, and quality is without substantially becoming Change.Above-mentioned result of the test shows, this product storage quality under prescribed conditions is stable, can store for a long time.
During use, add according to 0.5% ratio in milk cow forage, or oral by drinking-water according to Chinese medical discrimination result, rise To blood circulation promoting and blood stasis dispelling, expelling wind and removing dampness, dredging collateral eliminating impediment, spleen reinforcing stomach invigorating, promoting diuresis to eliminate damp pathogen, nourishing blood for regulating menstruation, nurse one's health blood vessels, liver and kidney tonifying, receive Hold back and admittedly take off, control stagnation of QI due to depression of the liver, there is the function adjusting flora simultaneously.
Embodiment 2
Take Poria 20kg, Herba Plantaginis 15kg, Serissa foetida 11 kg, Radix Angelicae Sinensis 11kg, Radix Salviae Miltiorrhizae 9kg, Radix Dipsaci 9kg, Semen Astragali Complanati 9kg, Herba cuscutae Sub-9kg, Flos Chrysanthemi 7kg, Rhizoma Cyperi 8kg, Fructus Lycii 6kg, Radix Astragali 10kg, Rhizoma Atractylodis Macrocephalae 6kg, Radix Angelicae Dahuricae 6kg, Rhizoma Dioscoreae 18kg, Radix Paeoniae Alba 7kg are burnt Fructus Crataegi 7kg, Radix Glycyrrhizae 1.2kg, microbial ecological agent 0.25kg, enzyme preparation 0.023 kg.
Described microbial ecological agent is that the cattle and sheep tailored version that Beijing Tian Feng Ying Tai Bioisystech Co., Ltd produces is combined micro- Ecological agent: Wei Er strengthens WSR-01, and main component includes enterococcus faecalis, Lactobacillus plantarum, bacillus subtilis, lichens spore bar Bacterium, enzyme preparation, antibacterial peptide (patent) etc., total viable count >=2,000,000,000 cfu/g.On the one hand this product can effectively suppress pathogenic bacterium to exist Field planting in intestinal walls, produces the bioactive substance having inhibitory action to pathogenic bacterium, on the other hand can produce organic acid, stable Ruminal pH value, stimulates rumen microorganism growth, and the decomposition improving feedstuff absorbs, the flora of decomposition of cellulose in significant stimulation cud With the propagation that lactic acid utilizes bacterium, the digestion increasing promotion cellulose of cellulose-decomposing bacterium, bacillus subtilis, lichens spore bar Bacterium produces protease, amylase, improves efficiency of feed utilization, improves the immune function of milch cow, sets up optimum the following of Contents in Cows health Ring, reduces the infertility induced because of raising dairy cattle mismanagement.
Described enzyme preparation is to build the Hylotelephium erythrostictum (Miq.) H.Ohba prestige 2X powder that bright industry (Zhuhai) company limited produces, by α-amylase, wood Dextranase, cellulase, protease, 1,4 beta-glucanase, pectase, amylopectase form, can be by phase by enzyme hydrolysis effect Protein, starch and the non-starch polysaccharides(nsp) answered is hydrolyzed to oligopeptide, aminoacid, oligosaccharide, oligosaccharide and monosaccharide, promotes that milch cow is to accordingly Digesting and assimilating of protein and polysaccharide, improves the feed digestibility of milch cow, improves milk cow production performance, supplements the endogenous of milch cow Enzyme, it is thus achieved that higher rate of return on investment.
Now each composition Chinese herbal medicine is added during preparation the powder being processed into 30 mesh in pulverizer, sieves, add Tiny ecosystem afterwards Preparation: 0.25kg, enzyme preparation: 0.023kg, then mix homogeneously, finally pelletize, packaging, saves backup.
This product, according to listing terms of packing, in temperature 40 DEG C ± 2 DEG C, is deposited under the conditions of relative humidity 75% ± 5% 3 months, Quality, without significant change, in temperature 25 DEG C ± 2 DEG C, is deposited under the conditions of relative humidity 60% ± 10% 22 months, and quality is without substantially becoming Change.Above-mentioned result of the test shows, this product storage quality under prescribed conditions is stable, can store for a long time.
During use, add according to 1% ratio in milk cow forage, or oral by drinking-water according to Chinese medical discrimination result, play Blood circulation promoting and blood stasis dispelling, clearing away heat and cooling blood, dispelling cold and removing dampness, stomach invigorating of invigorating blood circulation, supporing yang antidiarrheal, warming the spleen whets the appetite, and has the function adjusting flora simultaneously.
Embodiment 3,
Take Poria 15kg, Herba Plantaginis 12kg, Serissa foetida 8 kg, Radix Angelicae Sinensis 8kg, Radix Salviae Miltiorrhizae 7kg, Radix Dipsaci 7kg, Semen Astragali Complanati 7kg, Semen Cuscutae 7kg, Flos Chrysanthemi 5kg, Rhizoma Cyperi 5kg, Fructus Lycii 5kg, Radix Astragali 8kg, Rhizoma Atractylodis Macrocephalae 6kg, Radix Angelicae Dahuricae 5kg, Rhizoma Dioscoreae 16kg, Radix Paeoniae Alba 5kg, Jiaoshan Hill Short, bristly hair or beard 5kg, Radix Glycyrrhizae 1kg, microbial ecological agent 0.5kg, enzyme preparation 0.05 kg.
Described microbial ecological agent is that the cattle and sheep tailored version that Beijing Tian Feng Ying Tai Bioisystech Co., Ltd produces is combined micro- Ecological agent: Wei Er strengthens WSR-01, and main component includes enterococcus faecalis, Lactobacillus plantarum, bacillus subtilis, lichens spore bar Bacterium, enzyme preparation, antibacterial peptide (patent) etc., total viable count >=2,000,000,000 cfu/g.On the one hand this product can effectively suppress pathogenic bacterium to exist Field planting in intestinal walls, produces the bioactive substance having inhibitory action to pathogenic bacterium, on the other hand can produce organic acid, stable Ruminal pH value, stimulates rumen microorganism growth, and the decomposition improving feedstuff absorbs, the flora of decomposition of cellulose in significant stimulation cud With the propagation that lactic acid utilizes bacterium, the digestion increasing promotion cellulose of cellulose-decomposing bacterium, bacillus subtilis, lichens spore bar Bacterium produces protease, amylase, improves efficiency of feed utilization, improves the immune function of milch cow, sets up optimum the following of Contents in Cows health Ring, reduces the infertility induced because of raising dairy cattle mismanagement.
Described enzyme preparation is to build the Hylotelephium erythrostictum (Miq.) H.Ohba prestige 2X powder that bright industry (Zhuhai) company limited produces, by α-amylase, wood Dextranase, cellulase, protease, 1,4 beta-glucanase, pectase, amylopectase form, can be by phase by enzyme hydrolysis effect Protein, starch and the non-starch polysaccharides(nsp) answered is hydrolyzed to oligopeptide, aminoacid, oligosaccharide, oligosaccharide and monosaccharide, promotes that milch cow is to accordingly Digesting and assimilating of protein and polysaccharide, improves the feed digestibility of milch cow, improves milk cow production performance, supplements the endogenous of milch cow Enzyme, it is thus achieved that higher rate of return on investment.
Now each composition Chinese herbal medicine is added during preparation the powder being processed into 200 mesh in pulverizer, sieves, add Tiny ecosystem afterwards Preparation: 0.2kg, enzyme preparation: 0.02kg, then mix homogeneously, finally pelletize, packaging, saves backup.
This product, according to listing terms of packing, in temperature 40 DEG C ± 2 DEG C, is deposited under the conditions of relative humidity 75% ± 5% 3 months, Quality, without significant change, in temperature 25 DEG C ± 2 DEG C, is deposited under the conditions of relative humidity 60% ± 10% 22 months, and quality is without substantially becoming Change.Above-mentioned result of the test shows, this product storage quality under prescribed conditions is stable, can store for a long time.
During use, add according to 2% ratio in milk cow forage, or oral by drinking-water according to Chinese medical discrimination result, play Blood circulation promoting and blood stasis dispelling, expelling wind and removing dampness, dredging collateral eliminating impediment, spleen reinforcing stomach invigorating, promoting diuresis to eliminate damp pathogen, nourishing blood for regulating menstruation, nurse one's health blood vessels, liver and kidney tonifying, convergence Gu de-, control stagnation of QI due to depression of the liver, there is the function adjusting flora simultaneously.
Testing accordingly of the present invention uses random double blind test method to carry out various dose preventing and treating through mirror as a example by embodiment 1 It is set to the infertility ill milch cow test of natural occurrence, sets conventional medicine process group and blank group, at conventional medicine simultaneously Reason prescription case is ciprofloxacin 150ppm drinking-water 5-7 days, FSH 100 200 unit, and 1 times/day of intramuscular injection continues 2 3 times, after oestrusing, use interstitialcellstimulating hormone (ICSH) 100 200 unit intramuscular injection instead;Blank group does not make any process;Test group uses The present invention divides high, normal, basic three dosage that is 1.0%, 1.5%, 2.0% ratio to add in sheep roughage, is used in conjunction 7 days.Observe the present invention couple The preventive and therapeutic effect of the ill sheep of infertility, to inquire into its science applied in Cow product.Result shows, the present invention is for certainly So infertility ill sheep preventing and treating of morbidity, the pregnancy rate of low dose group is 70%, and the pregnancy rate of two dosage groups of senior middle school is 90%;Often Rule drug treating group pregnancy rate 70%, blank group pregnancy rate is only 10%, low dose group treatment compared with conventional medicine process group Quite, two dosage group curative effects of senior middle school are substantially better than conventional medicine process group to effect;Difference is the most notable compared with blank group.
From the point of view of result of the test, the present invention has blood circulation promoting and blood stasis dispelling, clearing away heat and cooling blood, dispelling cold and removing dampness, stomach invigorating of invigorating blood circulation, supporing yang only Rushing down, warming the spleen whets the appetite, and has adjustment flora simultaneously, and the function such as have no side effect.Facing to examine, process of the test not finding, this medicine has not Good reaction.Should according to circumstances and cost accounting in actual production, it is proposed that face and examine middle application preferably middle dosage 1.5%, be used in conjunction 7 days It it is a course for the treatment of.Test medication 1 the symptom course for the treatment of is improved, and pregnancy rate significantly improves, but now should continue medication one treatment Journey, to consolidate curative effect, prevents recurrence.
Acute toxicity test:
Use horn method white mice acute toxinology experiment, select 10 healthy Kun Ming mice, be randomly divided into 2 groups, often organize 5 Only, test group every gavages 0.5g(and be equivalent to 21.5g/kg body weight every day) decocting liquid of the present invention, matched group every fills every day Take same dose of normal saline.Observe 7 days, finally it all cutd open and kill, observe internal organs without observing ANOMALOUS VARIATIONS, Liver and kidney spleen group Knitting and observe the most no abnormal, hemogram and serum GPT activity compare without significant difference with matched group.Milch cow is being carried out body The toxicity test result of animal shows, the medicine of the present invention, during whole 7 days feeding experiments, tests milch cow well-grown, Have no any toxic and side effects, consistent with test mice result, the LD of prescription of the present invention is described50It is far longer than 21.5g/kg body Weight, by acute toxinology experiment classification, this pure Chinese medicine weighting agent prescription belongs to non-poisonous material, is safe and reliable.
Subacute toxicity test:
For understanding the subacute toxicity situation of medicine of the present invention, carry out this test at the enterprising row of mice, in experimental period, except high agent Outside amount group causes palatability difference affect and search for food because drug dose is excessive, remaining respectively organizes mice appetite, behavior and feces all normally, Physically well developing, without any poisoning symptom, the hemogram of each group and serum GPT activity are all within normal range.Dosage is examined by facing 3-4 times feeds 30 days, has no any toxic and side effects, illustrates that the medicine of the present invention faces that to examine the dosage of medication be the safest.
Below for the case cured:
1) there are 3 breast milk cattle cattle farm, Xinxiang, Henan, and appetite is strong, Repeat breeding, then with embodiment 1 medical treatment, and mixed feeding, often Medicine 15g mixed by 1kg feedstuff.Medication 5~7 days, oestrused after 20 days, and breeding is become pregnant.
2) veterinary hospital of Henan Science and Technology College saw and treated patients infertility disease milch cow 137 example in 1 year, and it mainly shows the estrus cycle Long, ovarian atrophy, hardening, strength of uterine contraction weakens, and lactogenic is decreased obviously;Or again and again oestrus, external genital is sagging, congested, sleeping ground Time outer vaginal orifice open, with flowing out transparent secretions, disposition is rough, calls thicker like ram sound time serious, frequent mounting, Again and again urinating, there is depression in afterbody, and each oestrus 6~8 days, Ipsilateral ovary enlargement during examination per rectum, follicle skin depth is rich in bullet Property, touch substantial part, have follicular fluid to fluctuate;Or lochia is detained or efflux time extends, cervix uteri is in week in puerperal 1~2 Below still opening, lochia gradually becomes mucus from light red.Preventing and treating: add the beast of the present invention according to 1.5-2% in feedstuff Medicine, uses 1 course for the treatment of, and pregnancy rate reaches 70.1%(96/137), use 2 courses for the treatment of, pregnancy rate reaches 89.9%(123/137).
From above test situation it can be seen that the present invention has significant curative effect to preventing and treating barrenness of milk cow, its preventive effect is also Clearly, there is the good prospect of its popularization and application, non-nuisance and noresidue green milk and meat product will be promoted The sound development of processing industry.

Claims (2)

1. treating a veterinary drug for barrenness of milk cow, it includes Chinese medicinal components, microbial ecological agent and enzyme preparation, it is characterised in that: (1) Poria 15-30 weight portion, Herba Plantaginis 12-30 weight portion, Serissa foetida 8-15 weight portion, Radix Angelicae Sinensis 8-15 weight portion, pellet are chosen Ginseng 7-15 weight portion, Radix Dipsaci 7-15 weight portion, Semen Astragali Complanati 7-15 weight portion, Semen Cuscutae 7-15 weight portion, Flos Chrysanthemi 5-10 weight Part, Rhizoma Cyperi 5-15 weight portion, Fructus Lycii 5-12 weight portion, Radix Astragali 8-20 weight portion, Rhizoma Atractylodis Macrocephalae 6-12 weight portion, Radix Angelicae Dahuricae 5-10 weight Part, Rhizoma Dioscoreae 16-30 weight portion, Radix Paeoniae Alba 5-12 weight portion, Fructus Crataegi (parched to brown) 5-15 weight portion, Radix Glycyrrhizae 1-3 weight portion, microbial ecological agent 0.2-0.5 weight portion, enzyme preparation 0.02-0.05 weight portion;(2) when preparing, each composition Chinese herbal medicine chosen is added pulverizer In be processed into the powder of 30-200 mesh, sieve, rear add microbial ecological agent 0.5 weight portion, enzyme preparation 0.05 weight portion, then mix Close uniformly, finally pelletize, complete preparation.
A kind of veterinary drug treating barrenness of milk cow, it is characterised in that: choose (1) Poria 30 weight Part, Herba Plantaginis 30 weight portion, Serissa foetida 15 weight portion, Radix Angelicae Sinensis 15 weight portion, Radix Salviae Miltiorrhizae 15 weight portion, Radix Dipsaci 15 weight portion, husky Garden son 15 weight portions, Semen Cuscutae 15 weight portion, Flos Chrysanthemi 10 weight portion, Rhizoma Cyperi 15 weight portion, Fructus Lycii 12 weight portion, the Radix Astragali 20 weight Amount part, the Rhizoma Atractylodis Macrocephalae 12 weight portion, the Radix Angelicae Dahuricae 10 weight portion, Rhizoma Dioscoreae 30 weight portion, the Radix Paeoniae Alba 12 weight portion, Fructus Crataegi (parched to brown) 15 weight portion, Radix Glycyrrhizae 3 weight portions, microbial ecological agent 0.5 weight portion, enzyme preparation 0.05 weight portion;(2) each composition Chinese herbal medicine will chosen when preparing Add the powder being processed into 30-200 mesh in pulverizer, sieve, rear addition microbial ecological agent 0.5 weight portion, enzyme preparation 0.05 weight Amount part, then mix homogeneously, finally pelletize, and completes preparation.
CN201610279528.6A 2016-05-03 2016-05-03 Veterinary drug for treating cow infertility Pending CN105727272A (en)

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Application publication date: 20160706