CN105726899A - Pharmaceutical composition containing folium artemisiae argyi for controlling nervous type lumbar vertebra pain and preparing method thereof - Google Patents
Pharmaceutical composition containing folium artemisiae argyi for controlling nervous type lumbar vertebra pain and preparing method thereof Download PDFInfo
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- CN105726899A CN105726899A CN201610231930.7A CN201610231930A CN105726899A CN 105726899 A CN105726899 A CN 105726899A CN 201610231930 A CN201610231930 A CN 201610231930A CN 105726899 A CN105726899 A CN 105726899A
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/646—Arachnids, e.g. spiders, scorpions, ticks or mites
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- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
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- A61K36/07—Basidiomycota, e.g. Cryptococcus
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
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- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention belongs to the field of traditional Chinese medicine and relates to a pharmaceutical composition containing folium artemisiae argyi for controlling nervous type lumbar vertebra pain and a preparing method thereof.The pharmaceutical composition is mainly prepared from, by weight, 16-23 parts of folium artemisiae argyi, 16-22 parts of cassia twig, 12-18 parts of pith of Himalayan trevesia, 7-14 parts of longstamen onion bulb, 9-15 parts of rhizome of chuanxiong, 8-12 parts of herba asari, 4-11 parts of flos sophorae, 8-12 parts of poria cocos, 4-9 parts of scorpion, 4-8 parts of dried rehmannia root, 5-11 parts of ganoderma lucidum, 5-10 parts of frankincense, 4-7 parts of radix scutellariae and 6-11 parts of licorice root.The pharmaceutical composition is merely prepared from Chinese herbal medicine, can promote blood circulation to remove blood stasis, strengthen back and bones and relieve pain, and can effectively control nervous type lumbar vertebra pain.The pharmaceutical composition is definite in treatment effect, capable of becoming effective quickly, capable of preventing relapse, safe and free of side and toxic effect.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of prevent and treat nervous system type lumbar vertebra pain medicine containing Folium Artemisiae Argyi
Compositions and preparation method thereof.
Background technology
The nervous system type lumbar vertebra pain i.e. sclerotin of lumbar vertebra, intervertebral disc, ligament, muscle generation pathological changes, and then pressure
Compel, traction stimulation lumbar vertebra is neural thus complicated and diversified symptom occurs.Its cardinal symptom: can not uprightly,
Headache, dizziness, blurred vision, hypomnesis, lumbar vertebra are ached, inappetence, regurgitation, vomiting,
Weakness of the lower extremities, severe patient may cause paralysis.
In China's mid-aged population, 97% suffers from lumbar disc disease, and wherein concurrency nervous system type lumbar vertebra pain is occurred frequently.
In recent years, the trend of rejuvenation, crowd's morbidity in less than 40 years old up to more than 25% are presented again.
The traditional Chinese medical science thinks that primary disease belongs to Chinese medicine " atrophic debility of bones " category, how can not fill because of deficiency of kidney essence, kidney yang deficiency
The raw marrow of bone, deficiency of kidney yin, essence are become homeless foster, it is impossible to support marrow.
Treatment nervous system type lumbar vertebra pain there is no effective medicine the most both at home and abroad, and the traditional Chinese medical science is mainly to mend
Liver and kidney, wind-damp dispelling, reducing swelling and alleviating pain, relaxing muscles and tendons to promote blood circulation is main, is aided with existing Chinese herbal medicine and treats.
Massage and the effect that fixing braking, Manipulation therapy are outer power, can only play temporary transient analgesic effect,
And the purpose for the treatment of can not be reached.Acupuncture method can restore menstrual flow and invigorate blood circulation and have analgesic effect, can eliminate pain,
But acupuncture can only help out for nervous system type lumbar vertebra pain.Treatment treatment primary disease relies primarily on medicine and controls
Treat, block therapy be drug injection around pain spot and nerve root, but relatively big to human injury, no
The most conventional.Naturopathy is to act on human body (such as infrared ray, magnetic, electricity) by various physical agents, rises
To antiinflammatory, pain relieving, add the purpose of quick-recovery, be highly effective to improving clinical symptoms, but right
Human body has certain injury.Operative treatment is mainly used in having a strong impact on life, work and rest person, warp
Non-operative treatment nonresponder.Operation changes the original organizational structure of human body, belongs to traumatic therapy.
Patient is more painful, surgical disruption tissue, causes the change of human tissue structure, easily increases
The pathological changes of other tissue, through such as, some patient, after a period of time after surgery, easily causes other waist
The regression of intercalated disc or cause bulging in various degree or prominent, is also easy to produce nerve and sticks or legs and feet fiber crops
Wood, loses consciousness, and is particularly susceptible initiation hyperosteogeny or vertebra is unstable.So operative therapy can only be
Using at a puss, waist disease of dashing forward belongs to self limiting or self-healing property disease to a certain extent, should select as far as possible
Use conservative treatment.
Therefore it is crucial for selecting timely, regular, effective, not have side effect Therapeutic Method, external traditional Chinese medicinal application
The advantage for the treatment of nervous system type lumbar vertebra pain maximum is to effect a radical cure from pathology.Nowadays in treatment nervous system type
Lumbar vertebra pain aspect, decomposes the dose difficulty of arrival disease sites owing to oral medicine also exists medicine by internal organs
To control, the property of medicine is strong injures internal organs, and the property of medicine is low does not reaches the drawback of therapeutic effect, and people will
Sight turns to the individual variation according to people to need on the liniment of scalable property of medicine intensity.Holy according to the traditional Chinese medical science
Allusion quotation Huangdi's Internal Classics is recorded, and in tradition doctor's strange method of bone, maximally efficient means are in water-soluble transdermal art
Room temperature dresses therapy, is commonly called as " poultice ", reconciles into watery wine etc. after referring to pulverize high-quality Chinese medicine formula
Pasty state, applies a kind of transdermal methods carrying out treating in local.Feature is not heat, and dose is big, free
Good.Gu has saying of " sticking with paste gas hundred cream ", and acting on affected site, its usefulness surmounts common unguentum tens
Portion, or even hundreds of times, have penetration strong, absorbs the features such as fast.
Chinese patent application CN103721080A discloses one and treats cervical spondylosis, lumbar spondylosis and ischium
Neuralgic Chinese medicine composition, by Flos Carthami, Radix Notoginseng, Sanguis Draxonis, Semen Persicae (parched), Radix Achyranthis Bidentatae, Pheretima, ground beetle,
The Cortex Eucommiae, Radix Dipsaci, Herba Taxilli, Olibanum (processed), Myrrha (processed), catechu, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Rhizoma Gastrodiae,
It is formulated that Radix Glycyrrhizae Preparata and parching to brown melon seed press certain weight ratio, and the party is used for treating cervical spondylosis, lumbar spondylosis
And sciatica medicine instant effect, but medical material is multiple numerous and diverse, and wherein ground beetle is slightly poisonous, has human body
Toxic and side effects.
Summary of the invention
For solving the deficiencies in the prior art, it is an object of the invention to provide a kind of preventing containing Folium Artemisiae Argyi
Control nervous system type lumbar vertebra pain pharmaceutical composition and preparation method thereof.
For realizing the purpose of the present invention, the research of the present inventor's foundation theory of Chinese medical science and clinic test repeatedly
And checking, it is provided that a kind of prevent and treat nervous system type lumbar vertebra pain pharmaceutical composition, described medicine containing Folium Artemisiae Argyi
Compositions is mainly prepared from by the raw material of following parts by weight:
Folium Artemisiae Argyi 16-23 part, Ramulus Cinnamomi 16-22 part, Medulla Trevesiae palmatae 12-18 part, Bulbus Allii Macrostemonis 7-14 part, Rhizoma Chuanxiong
9-15 part, Herba Asari 8-12 part, Flos Sophorae 4-11 part, Poria 8-12 part, Scorpio 4-9 part, Radix Rehmanniae 4-8
Part, Ganoderma 5-11 part, Olibanum 5-10 part, Radix Scutellariae 4-7 part and Radix Glycyrrhizae 6-11 part.
Preferably, the nervous system type lumbar vertebra pain pharmaceutical composition of preventing and treating containing Folium Artemisiae Argyi of the present invention is mainly
It is prepared from by the raw material of following parts by weight:
Folium Artemisiae Argyi 16 parts, Ramulus Cinnamomi 16 parts, Medulla Trevesiae palmatae 12 parts, Bulbus Allii Macrostemonis 7 parts, Rhizoma Chuanxiong 9 parts, Herba Asari 8
Part, 4 parts of Flos Sophorae, 8 parts of Poria, Scorpio 4 parts, 4 parts of the Radix Rehmanniae, Ganoderma 5 parts, Olibanum 5 parts,
Radix Scutellariae 4 parts and 6 parts of Radix Glycyrrhizae.
Preferably, the nervous system type lumbar vertebra pain pharmaceutical composition of preventing and treating containing Folium Artemisiae Argyi of the present invention is mainly
It is prepared from by the raw material of following parts by weight:
Folium Artemisiae Argyi 19 parts, Ramulus Cinnamomi 19 parts, Medulla Trevesiae palmatae 15 parts, Bulbus Allii Macrostemonis 10 parts, Rhizoma Chuanxiong 12 parts, Herba Asari
10 parts, 7 parts of Flos Sophorae, 10 parts of Poria, Scorpio 6 parts, 6 parts of the Radix Rehmanniae, Ganoderma 8 parts, Olibanum 7
Part, Radix Scutellariae 5 parts and 8 parts of Radix Glycyrrhizae.
Preferably, the nervous system type lumbar vertebra pain pharmaceutical composition of preventing and treating containing Folium Artemisiae Argyi of the present invention is mainly
It is prepared from by the raw material of following parts by weight:
Folium Artemisiae Argyi 23 parts, Ramulus Cinnamomi 22 parts, Medulla Trevesiae palmatae 18 parts, Bulbus Allii Macrostemonis 14 parts, Rhizoma Chuanxiong 15 parts, Herba Asari
12 parts, 11 parts of Flos Sophorae, 12 parts of Poria, Scorpio 9 parts, 8 parts of the Radix Rehmanniae, Ganoderma 11 parts, Olibanum
10 parts, Radix Scutellariae 7 parts and 11 parts of Radix Glycyrrhizae.
Preferably, described pharmaceutical composition is made into unguentum, gel or spray.
Preferably, the preparation method of described pharmaceutical composition comprises the steps of
S1, respectively weigh Folium Artemisiae Argyi, Ramulus Cinnamomi, Medulla Trevesiae palmatae, Bulbus Allii Macrostemonis, Rhizoma Chuanxiong, Herba Asari, Flos Sophorae, Poria,
Scorpio, the Radix Rehmanniae, Ganoderma, Olibanum, Radix Scutellariae and Radix Glycyrrhizae, standby after pulverizing；
S2, in medical material, add the distilled water of initial 5-10 times of weight of medical material, soak 20-25 hour,
Decoct 2-4 hour, filter and retain filtrate；Add the purified water of initial 4-8 times of weight of medical material, decoct
Boil 1-3 hour, filter and retain filtering residue；Merging filtrate, being concentrated into 60-70 DEG C of relative density is
The concentrated solution of 1.20-1.25 is standby；
S3, the ethanol of concentration 60-70% of 6-8 times of weight of addition, backflow in the filtering residue of step S2
Extracting 2 times, each 2-4 hour, filter and retain filtrate, merging filtrate, decompression is distilled off second
Alcohol, and it is standby to be concentrated into the concentrated solution that 60-70 DEG C of relative density is 1.20-1.25；
S4, the concentrated solution of step S2 and S3 gained is merged, continue to be concentrated into 60-70 DEG C the closeest
Degree is the Chinese medical concrete of 1.30-1.35, standby；
S5, in the Chinese medical concrete of step S4 gained, add adjuvant, utilize modern general Chinese medicine preparation
Technology makes the finished product preparation of clinical needs.
The source of Chinese crude drug, nature and flavor used by pharmaceutical composition of the present invention, return through and effect:
Folium Artemisiae Argyi: this product is the dried leaves of feverfew Chinese mugwort；Acrid in the mouth, hardship, warm in nature；Return liver,spleen,kidney warp；
Dispersing cold for relieving pain, warming the meridian for stopping bleeding.
Ramulus Cinnamomi: this product is the dry twig of canella Cortex Cinnamomi；Acrid in the mouth, sweet, warm in nature；GUIXIN, lung,
Bladder warp；Diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.
Medulla Trevesiae palmatae: this product is the leaf of Araliaceae Medulla Trevesiae palmatae；Mildly bitter flavor, property is put down；Return kidney channel；Blood stasis dispelling
Pain relieving.
Bulbus Allii Macrostemonis: this product is the dry bulb of liliaceous plant Allium macrostemon or Chinese onion；Acrid in the mouth, hardship, warm in nature；
Return lung, stomach, large intestine channel；Activating YANG and eliminating stagnation, circulation of qi promoting intestinal stasis relieving.
Rhizoma Chuanxiong: this product is the dry rhizome of samphire Rhizoma Chuanxiong；Acrid in the mouth, warm in nature；Return liver, gallbladder,
Pericardium channel；Blood-activating and qi-promoting, wind-expelling pain-stopping.
The Cortex Eucommiae: this product is the dry bark of the Eucommiaceae plant Cortex Eucommiae；Sweet in the mouth, warm in nature；Return liver, kidney channel；
Invigorating the liver and kidney, bone and muscle strengthening, antiabortive.
Herba Asari: this product is aristolochiaceae plant Herba Asari, Seoul Herba Asari or the dry herb of China's Herba Asari；
Acrid in the mouth, warm in nature；GUIXIN, lung, kidney channel；Expelling wind and cold, sensible pain relieving, warming the lung to resolve fluid-retention.
Flos Sophorae: this product is the dry flower and alabastrum of leguminous plant Chinese scholartree；Bitter in the mouth, cold nature；Return liver, big
Intestinal warp；Cooling blood for hemostasis, purging liver-fire.
Poria: this product is the dry sclerotia of On Polyporaceae Poria；Sweet in the mouth, light, property is put down；GUIXIN,
Lung, spleen, kidney channel；Promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.
Scorpio: this product is the dry body of Buthidae animal Scorpio；Acrid in the mouth, property is put down；Return Liver Channel；Breath
Wind spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.
The Radix Rehmanniae: this product is the Preparation process product of Radix Rehmanniae；Sweet in the mouth, slightly warm in nature；Return liver, kidney channel；YIN nourishing
Enriching blood, benefit essence fills out marrow.
Ganoderma: this product is the dry sporophore of On Polyporaceae Ganoderma lucidum (Leyss. Ex Fr.) Karst. or Ganoderma；Sweet in the mouth, property is put down；Return
The heart, lung, liver, kidney channel；Invigorating QI and tranquilization, relieving cough and asthma.
Olibanum: this product is Burseraceae Boswellia carterii platymiscium Boswellia carterii, wild Boswellia carterii etc., with its trunk skin zone
The oleo-gum-resin that wound oozes out is used as medicine；Acrid in the mouth, hardship, warm in nature；GUIXIN, liver, spleen channel；Promoting blood circulation and stopping pain.
Radix Scutellariae: this product is the dry root of labiate Radix Scutellariae；Bitter in the mouth, cold in nature；Return lung, gallbladder, spleen,
Large intestine, small intestine meridian；Heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L.；Sweet in the mouth, property
Flat；Gui Jing, GUIXIN, lung, spleen, stomach warp；Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, relieving spasm to stop pain, it is in harmonious proportion
All medicines.
The prescription analysis of Chinese medicine of the present invention:
According to the traditional Chinese medical science to preventing and treating the compatibility theory of the dialectical of nervous system type lumbar vertebra pain and Chinese crude drug, in conjunction with modern
Body constitution and the feature of modern pharmaceutical technology, the collocation ingredients of reasonable science, form this
Bright Chinese prescription.Prescription of the present invention is with Folium Artemisiae Argyi and Ramulus Cinnamomi as monarch drug, kidney-replenishing, and bone and muscle strengthening is invigorated blood circulation
Pain relieving；With Medulla Trevesiae palmatae, Bulbus Allii Macrostemonis, Rhizoma Chuanxiong, Herba Asari and Flos Sophorae as ministerial drug, silt of dispelling is promoted blood circulation, activating YANG and eliminating stagnation,
Blood-activating and qi-promoting；With Poria, Scorpio, the Radix Rehmanniae, Ganoderma, Olibanum with baikal skullcap root be used as the adjuvant medicine, activating YANG and eliminating stagnation,
Promoting the circulation of QI to relieve pain；With Radix Glycyrrhizae for making medicine, invigorating the spleen and replenishing QI, coordinating the actions of various ingredients in a prescription；The all medicines of monarch coordinate, association
With promoting, complement each other, be finally reached blood circulation promoting and blood stasis dispelling, strong waist is good for the back of the body, the effect of bone strengthening pain relieving, energy
Effectively prevent and treat nervous system type lumbar vertebra pain.Pharmaceutical composition determined curative effect of the present invention, instant effect, do not recur,
Safe without toxic side effect.
The preparation method of pharmaceutical composition of the present invention is as follows:
S1, respectively weigh Folium Artemisiae Argyi, Ramulus Cinnamomi, Medulla Trevesiae palmatae, Bulbus Allii Macrostemonis, Rhizoma Chuanxiong, Herba Asari, Flos Sophorae, Poria,
Scorpio, the Radix Rehmanniae, Ganoderma, Olibanum, Radix Scutellariae and Radix Glycyrrhizae, standby after pulverizing；
S2, in medical material, add the distilled water of initial 5-10 times of weight of medical material, soak 20-25 hour,
Decoct 2-4 hour, filter and retain filtrate；Add the purified water of initial 4-8 times of weight of medical material, decoct
Boil 1-3 hour, filter and retain filtering residue；Merging filtrate, being concentrated into 60-70 DEG C of relative density is
The concentrated solution of 1.20-1.25 is standby；
S3, the ethanol of concentration 60-70% of 6-8 times of weight of addition, backflow in the filtering residue of step S2
Extracting 2 times, each 2-4 hour, filter and retain filtrate, merging filtrate, decompression is distilled off second
Alcohol, and it is standby to be concentrated into the concentrated solution that 60-70 DEG C of relative density is 1.20-1.25；
S4, the concentrated solution of step S2 and S3 gained is merged, continue to be concentrated into 60-70 DEG C the closeest
Degree is the Chinese medical concrete of 1.30-1.35, standby；
S5, in the Chinese medical concrete of step S4 gained, add adjuvant, utilize modern general Chinese medicine preparation
Technology makes the finished product preparation of clinical needs.
Pharmaceutical composition of the present invention, comes from the achievement in research of China's Chinese medical theory and modern pharmacology, passes through
Pharmacodynamic experiment research, clinical practice treatment use, it was demonstrated that it is treated in terms of preventing and treating nervous system type lumbar vertebra pain
Effect is definite, has no adverse reaction, and has and is good for the back of the body, the effect of bone strengthening pain relieving to blood circulation promoting and blood stasis dispelling, strong waist, can have
Effect prevents and treats nervous system type lumbar vertebra pain.Pharmaceutical composition determined curative effect of the present invention, instant effect, do not recur, peace
Atoxic side effect.
Detailed description of the invention
Further describing the present invention below by way of specific embodiment, the present invention is not limited only to following enforcement
Example.Within the scope of the invention or without departing from present disclosure, spirit and scope, to this
Invention carry out change, combine or replace, will be apparent to the person skilled in the art,
It is included within the scope of the present invention.
Embodiment 1
The embodiment of the present invention 1 pharmaceutical composition is prepared from by the raw material of following parts by weight:
Folium Artemisiae Argyi 16 parts, Ramulus Cinnamomi 16 parts, Medulla Trevesiae palmatae 12 parts, Bulbus Allii Macrostemonis 7 parts, Rhizoma Chuanxiong 9 parts, Herba Asari 8
Part, 4 parts of Flos Sophorae, 8 parts of Poria, Scorpio 4 parts, 4 parts of the Radix Rehmanniae, Ganoderma 5 parts, Olibanum 5 parts,
Radix Scutellariae 4 parts and 6 parts of Radix Glycyrrhizae.
Preparation method:
S1, weigh respectively by Chinese prescription Folium Artemisiae Argyi, Ramulus Cinnamomi, Medulla Trevesiae palmatae, Bulbus Allii Macrostemonis, Rhizoma Chuanxiong, Herba Asari,
Flos Sophorae, Poria, Scorpio, the Radix Rehmanniae, Ganoderma, Olibanum, Radix Scutellariae and Radix Glycyrrhizae, standby after pulverizing；
S2, in medical material, add the distilled water of initial medical material 8 weight, soak 24 hours, decoct 3 little
Time, filter and retain filtrate；Add the purified water of initial 6 times of weight of medical material, decoct 2 hours,
Filter and retain filtering residue；Merging filtrate, is concentrated into the concentrated solution that 65 DEG C of relative densities are 1.20 standby；
S3, in the filtering residue of step S2, add the ethanol of concentration 65% of 7 times of weight, reflux, extract, 2
Secondary, each 3 hours, filter and retain filtrate, merging filtrate, decompression is distilled off ethanol, and dense
It is reduced to the concentrated solution that 65 DEG C of relative densities are 1.25 standby；
S4, the concentrated solution of step S2 and S3 gained is merged, continue to be concentrated into 65 DEG C of relative densities and be
The Chinese medical concrete of 1.30, standby；
S5, in the Chinese medical concrete of step S4 gained, add adjuvant, utilize modern general Chinese medicine preparation
Technology makes ointment.
Embodiment 2
The embodiment of the present invention 2 pharmaceutical composition is prepared from by the raw material of following parts by weight:
Folium Artemisiae Argyi 19 parts, Ramulus Cinnamomi 19 parts, Medulla Trevesiae palmatae 15 parts, Bulbus Allii Macrostemonis 10 parts, Rhizoma Chuanxiong 12 parts, Herba Asari
10 parts, 7 parts of Flos Sophorae, 10 parts of Poria, Scorpio 6 parts, 6 parts of the Radix Rehmanniae, Ganoderma 8 parts, Olibanum 7
Part, Radix Scutellariae 5 parts and 8 parts of Radix Glycyrrhizae.
Preparation method: with embodiment 1.
Embodiment 3
The embodiment of the present invention 3 pharmaceutical composition is prepared from by the raw material of following parts by weight:
Folium Artemisiae Argyi 23 parts, Ramulus Cinnamomi 22 parts, Medulla Trevesiae palmatae 18 parts, Bulbus Allii Macrostemonis 14 parts, Rhizoma Chuanxiong 15 parts, Herba Asari
12 parts, 11 parts of Flos Sophorae, 12 parts of Poria, Scorpio 9 parts, 8 parts of the Radix Rehmanniae, Ganoderma 11 parts, Olibanum
10 parts, Radix Scutellariae 7 parts and 11 parts of Radix Glycyrrhizae.
Preparation method: with embodiment 1.
Embodiment 4
The embodiment of the present invention 4 pharmaceutical composition is prepared from by the raw material of following parts by weight:
Folium Artemisiae Argyi 17 parts, Ramulus Cinnamomi 17 parts, Medulla Trevesiae palmatae 13 parts, Bulbus Allii Macrostemonis 8 parts, Rhizoma Chuanxiong 10 parts, Herba Asari 9
Part, 5 parts of Flos Sophorae, 9 parts of Poria, Scorpio 5 parts, 5 parts of the Radix Rehmanniae, Ganoderma 6 parts, Olibanum 6 parts,
Radix Scutellariae 5 parts and 7 parts of Radix Glycyrrhizae.
Preparation method: with embodiment 1.
Embodiment 5
The embodiment of the present invention 5 pharmaceutical composition is prepared from by the raw material of following parts by weight:
Folium Artemisiae Argyi 22 parts, Ramulus Cinnamomi 21 parts, Medulla Trevesiae palmatae 17 parts, Bulbus Allii Macrostemonis 13 parts, Rhizoma Chuanxiong 14 parts, Herba Asari
11 parts, 10 parts of Flos Sophorae, 11 parts of Poria, Scorpio 8 parts, 7 parts of the Radix Rehmanniae, Ganoderma 10 parts, Olibanum 9
Part, Radix Scutellariae 6 parts and 10 parts of Radix Glycyrrhizae.
Preparation method: with embodiment 1.
Test 1, pharmaceutical composition of the present invention cause sciatica experimental model to In Rat Lumbar intervertebral disk hernia
Test
1, experimental animal and packet: male SD rat 120, body weight 220～250g, experiment before
Animal housing raises 2 weeks, puts into experiment, overnight fasting before experiment, freely drink water after adaptation.Subsequently with
Machine is divided into 12 groups, often group 10.
Being grouped: taking one of which rat is sham operated rats, remaining is respectively organized rat and does the prominent operation of lumbar intervertebral disc,
It is divided into: (embodiment of the present invention 1 prepares for model group, positive controls (capsules for curing waist pain), A group
Ointment high dose group, middle dosage group, low dose group), the B group (ointment that the embodiment of the present invention 1 prepares
Agent high dose group, middle dosage group, low dose group), the C group (ointment that the embodiment of the present invention 1 prepares
High dose group, middle dosage group, low dose group).
2, modeling method:
In Rat Lumbar intervertebral disk hernia cause sciatica experimental model: model group: 10% chloral hydrate fiber crops
After liquor-saturated rat (3.5ml/kg, i.p.), it is 25-30mm with two interiliac line midpoints and hits exactly longitudinal incision, OK
L5 inferior articular process, L6 superior articular process and L5 hemilaminectomy, expose L5 dorsal root ganglion (dorsal
Root ganglion, DRG) and part spinal cord dural sac.At rat-tail nearly root row longitudinal incision, separate aobvious
Reveal 2 intervertebral spaces, cut 2 fibrous ring and take out autologous nucleus pulposus (about 0.4mg), taking-up autologous
Nucleus pulposus is covered in left side L5DRG and neighbouring epidural space.By PE-0503 tube at one end 8mm
Place's knotting, at L5 half canalis spinalis excision, cephalad inserts epidural space about 4mm, with the silk thread of 3-0
Being sewed up by this knot and be fixed on paraspinal muscle, other end subcutaneous tunnel leads between rat two ear, fixing,
Tube sealing.Layer-by-layer suture muscle, fascia.Skin suture after the visual area intramuscular injection of penicillin 30,000 unit.
Sham operated rats: take the autologous nucleus pulposus of afterbody but be not placed on exposure portion, the same model group of remaining operation.
After molding, to often organizing rat in preoperative 1 day and postoperative 1st, 3,5,7,14,21,28 days
Row general behavior observe and 50% mechanicalness remove sufficient threshold value (50%paw withdrawal threshold,
Mensuration 50%PWT).(1), general behavior is observed.Rat is positioned in lucite case,
Observe rat with or without irritated, bait limbs, dyskinesia, with or without situations such as gatism.(2)、
The mensuration of 50%PWT." Up-Down " method reported by Chaplan etc., surveys with von Frey hair
Determine rat 50%PWT, evaluate its machinery quick degree of pain.
Observation index is administered and terminates, and each treated animal is anaesthetized through 10% chloral hydrate 350mg/kg, draws materials.
Result of the test all represents with mean+SD (X ± SD), compares employing SAS statistics soft between group
Part generalized linear model carries out covariance analysis, has the standard of significance using p ＜ 0.05 as difference.
N is rat number.
3, trial drug and dosage regimen:
A group: trial drug is the pharmaceutical composition ointment of the present invention that the embodiment of the present invention 1 prepares,
It is deployed into variable concentrations ointment standby with distilled water.Take 3 groups of rats, be labeled as A group high dose group,
Middle dosage group and low dose group, high, medium and low dosage group rat gives drug regimen of the present invention every day respectively
Thing ointment amount is respectively 900mg/kg, 600mg/kg, 300mg/kg (clinical consumption per day of being respectively grown up
9,6,3 times).Give after modeling to smear 0.2ml/kg at the treatment autologous nucleus pulposus of group rat tails originally
1 time/the 12h of ointment of inventive embodiments 1 preparation, altogether 7d mono-course for the treatment of.
B group: trial drug is the pharmaceutical composition of the present invention that the embodiment of the present invention 2 prepares, to prescription
Case is with A group.
C group: trial drug is the pharmaceutical composition of the present invention that the embodiment of the present invention 3 prepares, to prescription
Case is with A group.
Sham operated rats, model group rats smear the normal saline of same volume.
Positive controls: positive control drug is capsules for curing waist pain (traditional Chinese medicines quasi-word Z10983078, Henan
Fu Rentang pharmaceutical Co. Ltd), positive drug group rat gives 0.8g/kg (for adult's clinical consumption per day every day
8 times), after being deployed into medicinal liquid with distilled water, give gavage after modeling immediately 1 time, after modeling, 8h is again
Secondary gavage 1 time, dosage 0.2g/kg, altogether 7d mono-course for the treatment of.
After being administered 3 days, take often group rat in be administered after the 7th day with urethane (1.5g/kg, i.p.) deeply fiber crops
Liquor-saturated, through 4 DEG C of heparinized salines of aorta quick filling, then irrigate 30 with the paraformaldehyde of 4%
Min, dissects and takes out operation homonymy L5DRG, carries out frozen section (slice thick after fixing, being dehydrated
Degree is 16 μm) and be collected in 24 orifice plates containing 0.01M PBS.Part section uses reduction
The expression of type nicotinamide adenine dinucleotide dehydrogenase (NADPH-d) method detection detection NOS,
Another part SABC SABC method detection COX-2 expresses.A series of DRG of every rat
In section, select NOS dyeing and each 4 of the section of COX-2 dyeing at random, micro-at comparable optical
Take pictures under the conditions of mirror.Photo uses Image-Pro Plus 6.0 image analysis software to process, the row positive
Cell counting.
4, result of the test: as shown in table 1.
The impact that NOS and COX-2 in DRG after rat test modeling is expressed by table 1 medicine
Note: compare with sham operated rats, ^P ＜ 0.05, ^^P ＜ 0.01；Compare with model group,*P ＜ 0.05,**P ＜
0.01；Compare with positive controls,#P ＜ 0.05,##P ＜ 0.01.
As it can be seen from table 1 NOS and the COX-2 positive cell of rats in sham-operated group L5 DRG
Number compares with model group significant difference (P ＜ 0.01), shows that In Rat Lumbar intervertebral disk hernia causes ischium god
Dysmenorrhoea experimental model moulding success.The NOS of test medicine group and positive controls rat L5 DRG and
COX-2 positive cell number compares with model control group all significant difference (P ＜ 0.05), therefore it can be said that
After the treatment of pharmaceutical composition ointment of the present invention and positive control capsules for curing waist pain medicine, all than model
NOS and the COX-2 positive cell number of the L5 DRG of group rat significantly reduces.The prompting of this result is originally
Invention pharmaceutical composition ointment and positive capsules for curing waist pain medicine the most effectively have suppression rat type lumbar vertebra
The effect of pain.The pharmaceutical composition ointment of the present invention that the embodiment of the present invention prepares, in institute's amount of reagent scope
Inside there is the effect trend preferably eliminating nervous system type lumbar vertebra pain.
5, conclusion (of pressure testing):
In Rat Lumbar intervertebral disk hernia causes in sciatica experimental model, and sham operated rats is big with model group
The data analysis of NOS and the COX-2 positive cell number of Mus L5 DRG shows modeling success.Through this
After the treatment of invention pharmaceutical composition ointment and positive control capsules for curing waist pain medicine, all big than model group
NOS and the COX-2 positive cell data of the L5 DRG of Mus reduce.This result points out medicine of the present invention
Compositions ointment and positive control capsules for curing waist pain medicine all can reduce In Rat Lumbar intervertebral disk hernia and cause to sit
NOS and the COX-2 content of osteoneuralgia, i.e. alleviates the hyperpathia of model, alleviates nervous system type waist
Vertebra pain shape.
Test data shows, the experimental administration A group (medicine that i.e. embodiment of the present invention 1 prepares in the present invention
Compositions) basic, normal, high dosage group, pharmaceutical composition B group (the i.e. embodiment of the present invention of the present invention
2 pharmaceutical compositions of the present invention prepared) basic, normal, high dosage group and pharmaceutical composition C group of the present invention
(pharmaceutical composition of the present invention that i.e. embodiment of the present invention 3 prepares) basic, normal, high dosage group experiment effect
Fruit is obvious, the pharmaceutical composition B group the most of the present invention (medicine of the present invention that i.e. embodiment of the present invention 2 prepares
Compositions) high dose group best results, there is preferable therapeutical effect for nervous system type lumbar vertebra pain.
Owing to describing the present invention by above preferred embodiment, at spirit and/or the model of the present invention
In enclosing, any replacement/for the present invention or combination implement the present invention, for those skilled in the art
Will be apparent from for Yuan, and be included among the present invention.
Claims (7)
1. one kind containing Folium Artemisiae Argyi prevent and treat nervous system type lumbar vertebra pain pharmaceutical composition, it is characterised in that described medicine
Compositions is mainly prepared from by the raw material of following parts by weight:
Folium Artemisiae Argyi 16-23 part, Ramulus Cinnamomi 16-22 part, Medulla Trevesiae palmatae 12-18 part, Bulbus Allii Macrostemonis 7-14 part, Rhizoma Chuanxiong 9-15
Part, Herba Asari 8-12 part, Flos Sophorae 4-11 part, Poria 8-12 part, Scorpio 4-9 part, Radix Rehmanniae 4-8 part, spirit
Sesame 5-11 part, Olibanum 5-10 part, Radix Scutellariae 4-7 part and Radix Glycyrrhizae 6-11 part.
2. contain Folium Artemisiae Argyi as claimed in claim 1 prevents and treats nervous system type lumbar vertebra pain pharmaceutical composition, its feature
Being, described pharmaceutical composition is mainly prepared from by the raw material of following parts by weight:
Folium Artemisiae Argyi 16 parts, Ramulus Cinnamomi 16 parts, Medulla Trevesiae palmatae 12 parts, Bulbus Allii Macrostemonis 7 parts, Rhizoma Chuanxiong 9 parts, Herba Asari 8 parts,
4 parts of Flos Sophorae, 8 parts of Poria, Scorpio 4 parts, 4 parts of the Radix Rehmanniae, Ganoderma 5 parts, Olibanum 5 parts, Radix Scutellariae 4 parts
With 6 parts of Radix Glycyrrhizae.
3. contain Folium Artemisiae Argyi as claimed in claim 1 prevents and treats nervous system type lumbar vertebra pain pharmaceutical composition, its feature
Being, described pharmaceutical composition is mainly prepared from by the raw material of following parts by weight:
Folium Artemisiae Argyi 19 parts, Ramulus Cinnamomi 19 parts, Medulla Trevesiae palmatae 15 parts, Bulbus Allii Macrostemonis 10 parts, Rhizoma Chuanxiong 12 parts, Herba Asari 10
Part, 7 parts of Flos Sophorae, 10 parts of Poria, Scorpio 6 parts, 6 parts of the Radix Rehmanniae, Ganoderma 8 parts, Olibanum 7 parts, Huang
A kind of reed mentioned in ancient books 5 parts and 8 parts of Radix Glycyrrhizae.
4. contain Folium Artemisiae Argyi as claimed in claim 1 prevents and treats nervous system type lumbar vertebra pain pharmaceutical composition, its feature
Being, described pharmaceutical composition is mainly prepared from by the raw material of following parts by weight:
Folium Artemisiae Argyi 23 parts, Ramulus Cinnamomi 22 parts, Medulla Trevesiae palmatae 18 parts, Bulbus Allii Macrostemonis 14 parts, Rhizoma Chuanxiong 15 parts, Herba Asari 12
Part, 11 parts of Flos Sophorae, 12 parts of Poria, Scorpio 9 parts, 8 parts of the Radix Rehmanniae, Ganoderma 11 parts, Olibanum 10 parts,
Radix Scutellariae 7 parts and 11 parts of Radix Glycyrrhizae.
5. as described in claim 1-4 is arbitrary, prevent and treat nervous system type lumbar vertebra pain pharmaceutical composition containing Folium Artemisiae Argyi,
It is characterized in that, described pharmaceutical composition is made into unguentum, gel or spray.
6. as described in claim 1-4 is arbitrary, prevent and treat nervous system type lumbar vertebra pain pharmaceutical composition containing Folium Artemisiae Argyi,
It is characterized in that, the preparation method of described pharmaceutical composition comprises the steps of
S1, weigh Folium Artemisiae Argyi, Ramulus Cinnamomi, Medulla Trevesiae palmatae, Bulbus Allii Macrostemonis, Rhizoma Chuanxiong, Herba Asari, Flos Sophorae, Poria, complete respectively
Scorpion, the Radix Rehmanniae, Ganoderma, Olibanum, Radix Scutellariae and Radix Glycyrrhizae, standby after pulverizing；
S2, in medical material, add the distilled water of initial 5-10 times of weight of medical material, soak 20-25 hour, decoct
2-4 hour, filter and retain filtrate；Add the purified water of initial 4-8 times of weight of medical material, decoct 1-3
Hour, filter and retain filtering residue；Merging filtrate, being concentrated into 60-70 DEG C of relative density is the dense of 1.20-1.25
Contracting liquid is standby；
S3, in the filtering residue of step S2, add the ethanol of concentration 60-70% of 6-8 times of weight, reflux, extract,
2 times, each 2-4 hour, filtering and retain filtrate, merging filtrate, decompression is distilled off ethanol, and dense
It is reduced to the concentrated solution that 60-70 DEG C of relative density is 1.20-1.25 standby；
S4, the concentrated solution of step S2 and S3 gained is merged, continue to be concentrated into 60-70 DEG C of relative density and be
1.30-1.35 Chinese medical concrete, standby；
S5, in the Chinese medical concrete of step S4 gained, add adjuvant, utilize modern general Chinese medicine preparation skill
Art makes the finished product preparation of clinical needs.
7. as described in claim 1-6 is arbitrary, prevent and treat nervous system type lumbar vertebra pain medicine group containing Folium Artemisiae Argyi for one kind
The preparation method of compound, it is characterised in that the preparation method of described pharmaceutical composition comprises the steps of
S1, weigh Folium Artemisiae Argyi, Ramulus Cinnamomi, Medulla Trevesiae palmatae, Bulbus Allii Macrostemonis, Rhizoma Chuanxiong, Herba Asari, Flos Sophorae, Poria, complete respectively
Scorpion, the Radix Rehmanniae, Ganoderma, Olibanum, Radix Scutellariae and Radix Glycyrrhizae, standby after pulverizing；
S2, in medical material, add the distilled water of initial 5-10 times of weight of medical material, soak 20-25 hour, decoct
2-4 hour, filter and retain filtrate；Add the purified water of initial 4-8 times of weight of medical material, decoct 1-3
Hour, filter and retain filtering residue；Merging filtrate, being concentrated into 60-70 DEG C of relative density is the dense of 1.20-1.25
Contracting liquid is standby；
S3, in the filtering residue of step S2, add the ethanol of concentration 60-70% of 6-8 times of weight, reflux, extract,
2 times, each 2-4 hour, filtering and retain filtrate, merging filtrate, decompression is distilled off ethanol, and dense
It is reduced to the concentrated solution that 60-70 DEG C of relative density is 1.20-1.25 standby；
S4, the concentrated solution of step S2 and S3 gained is merged, continue to be concentrated into 60-70 DEG C of relative density and be
1.30-1.35 Chinese medical concrete, standby；
S5, in the Chinese medical concrete of step S4 gained, add adjuvant, utilize modern general Chinese medicine preparation technology system
Become the finished product preparation that clinic needs.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104873631A (en) * | 2015-04-28 | 2015-09-02 | 即墨爱心医院 | Traditional Chinese medicinal composition for treating bone diseases, preparation method of traditional Chinese medicinal composition and bone disease therapeutic apparatus |
| CN105233152A (en) * | 2015-10-19 | 2016-01-13 | 广东聚智诚科技有限公司 | Traditional Chinese medicinal composition having function of relieving pain and preparation method of traditional Chinese medicinal composition |
| CN105434795A (en) * | 2015-12-08 | 2016-03-30 | 暨南大学 | Traditional Chinese medicine preparation containing folium artemisiae argyi and used for treating hyperostosis through external application |
| CN105456447A (en) * | 2015-12-30 | 2016-04-06 | 广东聚智诚科技有限公司 | Folium artemisiae argyi-containing traditional Chinese medicine composition with function of promoting blood circulation to remove stasis and preparation method thereof |
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2016
- 2016-04-12 CN CN201610231930.7A patent/CN105726899A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104873631A (en) * | 2015-04-28 | 2015-09-02 | 即墨爱心医院 | Traditional Chinese medicinal composition for treating bone diseases, preparation method of traditional Chinese medicinal composition and bone disease therapeutic apparatus |
| CN105233152A (en) * | 2015-10-19 | 2016-01-13 | 广东聚智诚科技有限公司 | Traditional Chinese medicinal composition having function of relieving pain and preparation method of traditional Chinese medicinal composition |
| CN105434795A (en) * | 2015-12-08 | 2016-03-30 | 暨南大学 | Traditional Chinese medicine preparation containing folium artemisiae argyi and used for treating hyperostosis through external application |
| CN105456447A (en) * | 2015-12-30 | 2016-04-06 | 广东聚智诚科技有限公司 | Folium artemisiae argyi-containing traditional Chinese medicine composition with function of promoting blood circulation to remove stasis and preparation method thereof |
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