CN105726841A - Drug for treating chronic bronchitis - Google Patents

Drug for treating chronic bronchitis Download PDF

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Publication number
CN105726841A
CN105726841A CN201610233063.0A CN201610233063A CN105726841A CN 105726841 A CN105726841 A CN 105726841A CN 201610233063 A CN201610233063 A CN 201610233063A CN 105726841 A CN105726841 A CN 105726841A
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parts
herba
chronic bronchitis
chinese
drug
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吴斌
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Ningbo Youmeike New Material Co Ltd
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Ningbo Youmeike New Material Co Ltd
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Abstract

The invention relates to a drug for treating chronic bronchitis.The drug is prepared from, by weight, 10 parts of purple quartz, 9 parts of Chinese holly leaves, 6 parts of a Siberian columbine meadowrue herb, 3 parts of Chinese ephedra, 8 parts of cassia twigs, 6 parts of asarum, 6 parts of pinellia ternate, 9 parts of Chinese parsnip roots, 12 parts of astragalus membranaceus, 5 parts of giant clam and 12 parts of hibiscus syriacus.In the application of the drug, the purple quartz benefits lower origin, warms the kidney and absorbs qi; the Chinese holly leaves nourishes yin and abates fever; the Siberian columbine meadowrue herb clears away heat and toxic materials and diminishes inflammation; the Chinese ephedra and the cassia twigs free lung and relieve asthma; the asarum and the pinellia ternate warm the middle warmer, eliminate rheum, expel cold and calm the adverse-rising energy; the Chinese parsnip roots and the astragalus membranaceus eliminate evil without healthy qi damage, and the astragalus membranaceus and Chinese parsnip roots secure the exterior without evil production; the giant clam calms the nerves and removes toxic materials after entering the kidney; the hibiscus syriacus has a sweet flavor, clears lung, eliminates phlegm, removes toxic materials and relieves pain.The medicinal materials are combined for usage and jointly achieve the effects of warming yang, dredging collaterals, dispelling cold, eliminating phlegm, relieving cough and relieving asthma.A clinical experiment proves that the drug can safely and effectively treat the chronic bronchitis.

Description

A kind of medicine for treating chronic bronchitis
Technical field
The present invention relates to a kind of Chinese medicine, be specifically related to a kind of medicine for treating chronic bronchitis.
Background technology
Chronic bronchitis is the chronic nonspecific inflammation of trachea-bronchial epithelial cell mucosa and surrounding tissue thereof.Clinically with cough, expectoration or with recurrent exerbation such as asthma for cardinal symptom, annual continue 3 months, continuous more than 2 years.Early symptom is slight, and more than winter attack, spring and summer is alleviated.Late period, symptom can exist throughout the year because of increased inflammation.Its Pathologic Characteristics is bronchus glandular hyperplasia and mucosa secretion increasing.The state of an illness is slow Progressive symmetric erythrokeratodermia progress, and Chang Bingfa obstructive emphysema, pulmonary hypertension often occurs severe patient, even pulmonary heart disease.
Occurring and the invasion and attack repeatedly developing normal and exopathogen of primary disease, lung, spleen, the dirty functional disorder of kidney three are closely related.Acute attack stage, mostly because of insufficiency of lung-QI, weakened defensive QI exopathogen is invaded, so that cough recurrent exerbation；Or because of chronic cough endlessly, recurrent exerbation, or body is empty with age, lung spleen deficiency of kidney-QI, water Tianjin not cloth, stops, check in lung in phlegm retention, causes long-term cough with asthma, or because ingest, the factor such as drink injure in lung, and then form primary disease.Pathological changes is prolonged not to heal, then lung spleen undermines in kidney, therefore the person of being in a bad way is often accompanied by asthma and can not put down sleeping, dynamic then more so failure of the kidney in receiving QI such as grade time.
Clinical manifestation
How slow symptom onset is, and the course of disease is longer, and some patients premorbid has the acute respiratory infection histories such as acute bronchitis, influenza or pneumonia, develops into primary disease due to protracted course of disease.Cardinal symptom is chronic cough, expectoration and breathes hard or with panting.The symptom initial stage is relatively light, and along with course advancement, because of recurrent respiratory tract infection, acute attack is more frequent, and symptom is also more serious, especially with winter for very.
1. cough: the cough of initial stage daystart is heavier, daytime is relatively light, and night in late period is also obvious, often has apasm of coughing to show effect, and accompany expectoration before sleeping.This is that secretions accumulates in caused by bronchial lumen owing to bronchial mucosa is congested, edema.Along with PD, cough is not healed all the year round.
2. expectoration: especially many with daystart expectoration, sputum is generally white mucus or serosity spumescence, occasionally can band blood.During this polyphyly nighttime sleep, coughre flex is blunt, air flue intracavity sputum pile up, daystart get up after because of position variation cause stimulation expectoration therefore.When acute attack is infected with antibacterial, amount of expectoration increases, and sputum then becomes sticky or purulence.
3. breathe hard and pant: how inconspicuous the course of disease initial stage is, when course advancement merge obstructive emphysema time then engender different the breathing hard of light and heavy degree, with after activity more so.Chronic bronchitis merges asthma or the patient of so-called chronic asthmatic bronchitis, especially when acute attack, the symptom panted often occurs, and is often accompanied by wheezing sound.
The diagnosis of this disease relies primarily on lab testing 1. x-ray inspection: early stage is often negative.Along with the progress of pathological changes, bronchial wall thickens, and bronchioles or alveolar spaces have inflammatory cell infiltration, X-ray film can find two lung marking increase, and in strip or netted, lower field is more than upper field.When being developed to emphysema, then the bright degree of lung field increases, and diaphragm declines and smooth, and activity weakens, and intercostal space is broadening.2. pulmonary function test: early stage, acute attack stage may occur in which that closing volume CV increase and maximal voluntary ventilation and 1 second expiration amount lower, and can recover to normally after treatment without substantially changing.If lung function tests during Complicated with Pulmonary edema due to disorder of QI, there is bigger help.3. Sputum culturing: may separate out the pathogenic bacterium such as hemophilus influenza, Diplococcus pneumoniae, alpha streptococcus.4. acute attack stage numeration of leukocyte and neutrophil count can increase.Type of panting blood eosinophils increase.
Drug therapy is anti-infectives 1.: the result of antibiotic sensitivity test carries out the selection of anti-infectives according to Sputum bacterial culture, to not can determine that pathogen person can take experiential therapy, and conventional penicillin, Sulfamethoxazole/trimethoprim etc..2. bronchodilator: dust head has anticholinergic agents, such as ipratropium bromide (ipratropium bromide)；Beta receptor excitomotor, such as albuterol；Theophylline class medicine, such as aminophylline.3. expectorant, dust head has ambroxol, carbocisteine.4. Treating Chronic Bronchitis with Traditional Chinese Medicine can use traditional Chinese medical herbal treatment, and effectiveness comparison is desirable.Simultaneously it should be noted that diet and living habit.
Medical material involved in the present invention is all recorded in " China's book on Chinese herbal medicine " as seen.
Summary of the invention
It is desirable to provide a kind of medicine for treating chronic bronchitis, by selecting suitable medical material and proportioning thereof, reach safely and effectively to cure the purpose of chronic bronchitis.
In order to achieve the above object, the present invention is by the following technical solutions:
A kind of medicine for treating chronic bronchitis, it is characterized in that, it is to be prepared from by the raw medicinal material of following weight proportion: Fluoritum 10 parts, Folium Mahoniae 9 parts, Herba thalictri sibirici 6 parts, 3 parts of Herba Ephedrae, Ramulus Cinnamomi 8 parts, Herba Asari 6 parts, the Rhizoma Pinelliae 6 parts, Radix Saposhnikoviae 9 parts, the Radix Astragali 12 parts, Concha Tridacna squamosa 5 parts, towards emperor 12 parts.
Illustrate the method have the benefit that below in conjunction with theories of Chinese materia medica
It has been recognised by the inventors that the basic pathogenesis of chronic bronchitis is mainly reflected as lung, spleen, kidney three deficiency of five ZANG-organs damage, and their mutual relation is unbalance, simultaneously the more sophisticated because of the participation of the factors such as expectorant, fire, the stasis of blood again.Under normal circumstances, lung governing qi, department breathes, and main Xuan Fasu drops, outer conjunction fur, the passage of the lifting that comes in and goes out for mechanism of qi.The spleen has the function to transport and transform nutrients, occupies middle Jiao, for the pivot of rising and falling of QI.Insufficiency of the spleen can not transmitting and distributing the fluids, poly-wet as expectorant, on damp-phlegm, stain is in lung, affects the unobstructed of mechanism of qi and sees cough with asthma, the disease such as cough up phlegm.Kidney governing inspiration, kidney yang virtual loss, gas loses and takes the photograph and receive, decline of the fire from the gate of life, body fluid defeatedization mistake department, and lung qi lifting is obstructed, and gasification function is not normal, aqueous vapor can not Xuanhua, for expectorant for drinking, obstructing airway；Damage of kidney-YIN, vehement in asthenic fire, lung Tianjin of burning, all can make impairment of dispersing and descending function of the lung, abnormal rising of lung-QI and cough with asthma is coughed up phlegm.Treatment should warming YANG dredging collateral, cold expelling eliminates the phlegm, and takes the photograph and receives and the respectful important department dropped regulating lung kidney.
The present invention uses: unit, the kidney warming improving inspiration by invigorating kidney-QI under Fluoritum tonification；Folium Mahoniae nourishing YIN for decreasing fever；The heat-clearing and toxic substances removing antiinflammatory cold in nature of Herba thalictri sibirici bitter in the mouth；Herba Ephedrae, Ramulus Cinnamomi, depressed lung-energy dispersing；Herba Asari, Rhizoma Pinelliae warming middle-JIAO exempt from drink, expelling cold pathogen and lowering adverse QI；Radix Saposhnikoviae joins the Radix Astragali, eliminating evil and just do not hinder, and the Radix Astragali obtains Radix Saposhnikoviae, consolidating superficial resistance and do not stay heresy；Concha Tridacna squamosa enters kidney and calms the nerves removing toxic substances；Towards the flat removing heat from the lung and dissipating phlegm of emperor's sweet in the mouth, the removing toxic substances all medicines of pain relieving share, and play warming YANG dredging collateral altogether, and cold expelling eliminates the phlegm, cough-relieving, the merit relievingd asthma.
Below in conjunction with clinical laboratory data, beneficial effects of the present invention is described:
1, physical data
Inventor collects 228 example thrombophlebitis patients between 2011 03 month-2014 years 03 month altogether.It is randomly divided into: treatment group 132 example, matched group 96 example.In treatment group 132 example patient, male 70 examples, female 62 example；38 ~ 79 years old age, 60.12 years old mean age；In matched group 96 example patient, male 52 examples, female 44 example；40 ~ 78 years old age, 58.36 years old mean age.The data such as two groups of sexes, age, courses of disease there was no significant difference, and has comparability.
Diagnostic criteria
1. clinically to cough, to spit for cardinal symptom or with panting, annual morbidity continues 3 months, and continuous 2 years or above (though cough clinically, expectorant, asthma shape continuous 2 years or more than, but annual morbidity continues the patient less than 3 months, if any clear and definite objective determination according to such as x-ray, pulmonary function etc. is also diagnosable.But still lack the diagnostic criteria of these objective determinations at present, need to be studied and defined further from now on).
2. the Other diseases (such as pulmonary tuberculosis, pneumoconiosis, pulmonary abscess, heart disease, cardiac insufficiency, bronchiectasis, bronchial asthma, chronic nasopharynx illness etc.) with cough, wheezing symptoms is got rid of.
The inclusive criteria 1. age was more than 18 years old；2. the diagnostic criteria of chronic bronchitis is met；3. clinical manifestation is that dyspnea, cough, amount of expectoration increase and purulent sputum, peripheral white blood cell more than 10*109/L or neutrophilic granulocyte number more than 75%；4. without severe cardiac, liver, kidney and disease of hematopoietic system, and need not oral or intravenous glucocorticoid person during treating.
Exclusion standard is 1. to trial drug allergy sufferers；2. immunodeficiency person；3. state of an illness weight, and need hospitalization patient.
2, Therapeutic Method
The capsule that the oral present invention specific embodiment 3 for the treatment of group prepares, every day 3 times.Treat 14.
Matched group is administered orally Sulfamethoxazole, 2 pieces/times, 2 times/d；Aminophylline, 0.1g/ time, 3 times/d.Treat 14.
3, criterion of therapeutical effect and therapeutic outcome
3.1 criterions of therapeutical effect
1. recovery from illness: symptom and the not enough slight person of pulmonary wheezing sound, or cough, expectorant, asthma shape take a turn for the better more than 9 one-tenths, X-ray film display recovers normally, and etiological examination shows that Sputum culturing is turned out cloudy；
2. effective: cough, expectorant, asthma shape take a turn for the better 6 one-tenths above or symptoms and pulmonary's wheezing sound is clearly better (+++ →+), and X-ray film show the front improvement of relatively treatment, and etiological examination shows that Sputum culturing is turned out cloudy substantially or pathogenic bacterium disappear substantially；
3. effective: to cough, expectorant, breathe heavily improvement more than 3 one-tenths, or symptom and pulmonary wheezing sound take a turn for the better (+++ → ++, or ++ →+), X-ray film takes a turn for the better before show relatively treatment, and etiological examination shows that Sputum culturing shows positive；
4. invalid: symptom and pulmonary's wheezing sound are without change, or improvement is less than 3 one-tenth persons, and symptom and pulmonary's wheezing sound add severe one, X-ray film inspection and etiological examination have no significant change before relatively treating.
3.2 treatment statistical results are in Table 1.
1 liang of table group comparitive study
Group n Recovery from illness Effective Effectively Invalid Total effective rate (%) Obvious adverse reaction example
Treatment group 132 32 78 10 12 90.91% 0
Matched group 96 18 45 12 21 78.13% 0
Visible, chronic bronchitis can safely and effectively be treated by the medicine that the present invention prepares, and cure rate is high.
Detailed description of the invention
In order to be more fully understood that and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.
Embodiment 1
Weigh: Fluoritum 10 grams, Folium Mahoniae 9 grams, Herba thalictri sibirici 6 grams, 3 grams of Herba Ephedrae, Ramulus Cinnamomi 8 grams, Herba Asari 6 grams, the Rhizoma Pinelliae 6 grams, Radix Saposhnikoviae 9 grams, the Radix Astragali 12 grams, Concha Tridacna squamosa 5 grams, towards emperor 12 grams；Add 8 times amount water, decoct 1.5 hours, filter；Filtering residue adds 6 times amount water, decocts 1 hour, filters；Merging filtrate, is concentrated into 120 grams, must meet the decoct of one day consumption of adult normal.
For treating chronic bronchitis.Oral, daily once.
Embodiment 2
Weigh: Fluoritum 10 grams, Folium Mahoniae 9 grams, Herba thalictri sibirici 6 grams, 3 grams of Herba Ephedrae, Ramulus Cinnamomi 8 grams, Herba Asari 6 grams, the Rhizoma Pinelliae 6 grams, Radix Saposhnikoviae 9 grams, the Radix Astragali 12 grams, Concha Tridacna squamosa 5 grams, towards emperor 12 grams；Add 10 times amount water, decoct 2 hours, filter；Filtering residue adds 8 times amount water, decocts 1.5 hours, filters；Merging filtrate, concentration, dry, packaging, the powder of one day consumption of adult normal must be met.
For treating chronic bronchitis.Oral, every bu is taken for twice sooner or later.
Embodiment 3
Weigh: Fluoritum 10 grams, Folium Mahoniae 9 grams, Herba thalictri sibirici 6 grams, 3 grams of Herba Ephedrae, Ramulus Cinnamomi 8 grams, Herba Asari 6 grams, the Rhizoma Pinelliae 6 grams, Radix Saposhnikoviae 9 grams, the Radix Astragali 12 grams, Concha Tridacna squamosa 5 grams, towards emperor 12 grams；Add 6 times amount water, decoct 3 times, decoct 1 hour every time, merge decoction liquor, concentration, dry, load capsule shells, the capsule of one day consumption of adult normal must be met.
For treating chronic bronchitis.Oral, every bu morning, noon and afternoon take for three times.

Claims (4)

1. the medicine being used for treating chronic bronchitis, it is characterized in that, it is to be prepared from by the raw medicinal material of following weight proportion: Fluoritum 10 parts, Folium Mahoniae 9 parts, Herba thalictri sibirici 6 parts, 3 parts of Herba Ephedrae, Ramulus Cinnamomi 8 parts, Herba Asari 6 parts, the Rhizoma Pinelliae 6 parts, Radix Saposhnikoviae 9 parts, the Radix Astragali 12 parts, Concha Tridacna squamosa 5 parts, towards emperor 12 parts.
2. the medicine for treating chronic bronchitis as claimed in claim 1, it is characterized in that, its preparation method is: weigh: Fluoritum 10 parts, Folium Mahoniae 9 parts, Herba thalictri sibirici 6 parts, 3 parts of Herba Ephedrae, Ramulus Cinnamomi 8 parts, Herba Asari 6 parts, the Rhizoma Pinelliae 6 parts, Radix Saposhnikoviae 9 parts, the Radix Astragali 12 parts, Concha Tridacna squamosa 5 parts, towards emperor 12 parts；Add 8 times amount water, decoct 1.5 hours, filter；Filtering residue adds 6 times amount water, decocts 1 hour, filters；Merging filtrate, is concentrated into 120 parts, obtains decoct；Above-mentioned part each means weight portion.
3. the medicine for treating chronic bronchitis as claimed in claim 1, it is characterized in that, its preparation method is: weigh: Fluoritum 10 parts, Folium Mahoniae 9 parts, Herba thalictri sibirici 6 parts, 3 parts of Herba Ephedrae, Ramulus Cinnamomi 8 parts, Herba Asari 6 parts, the Rhizoma Pinelliae 6 parts, Radix Saposhnikoviae 9 parts, the Radix Astragali 12 parts, Concha Tridacna squamosa 5 parts, towards emperor 12 parts；Add 10 times amount water, decoct 2 hours, filter；Filtering residue adds 8 times amount water, decocts 1.5 hours, filters；Merging filtrate, concentration, dry, packaging, obtain powder；Above-mentioned part each means weight portion.
4. the medicine for treating chronic bronchitis as claimed in claim 1, it is characterized in that, its preparation method is: weigh: Fluoritum 10 parts, Folium Mahoniae 9 parts, Herba thalictri sibirici 6 parts, 3 parts of Herba Ephedrae, Ramulus Cinnamomi 8 parts, Herba Asari 6 parts, the Rhizoma Pinelliae 6 parts, Radix Saposhnikoviae 9 parts, the Radix Astragali 12 parts, Concha Tridacna squamosa 5 parts, towards emperor 12 parts；Add 6 times amount water, decoct 3 times, decoct 1 hour every time, merge decoction liquor, concentration, dry, load capsule shells, obtain capsule；Above-mentioned part each means weight portion.
CN201610233063.0A 2016-04-15 2016-04-15 Drug for treating chronic bronchitis Pending CN105726841A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022119352A1 (en) * 2020-12-03 2022-06-09 (주)에스디생명공학 Antitussive and mucoactive composition comprising extract of hibiscus syriacus l. as active ingredient

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1463708A (en) * 2001-12-18 2003-12-31 魏生 Oral liquid for treating common cold and coughing
CN101940773A (en) * 2010-09-10 2011-01-12 重庆市南川区金佛山中药材品种培育研究所 Chinese medicinal herb for treating chronic bronchitis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1463708A (en) * 2001-12-18 2003-12-31 魏生 Oral liquid for treating common cold and coughing
CN101940773A (en) * 2010-09-10 2011-01-12 重庆市南川区金佛山中药材品种培育研究所 Chinese medicinal herb for treating chronic bronchitis

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022119352A1 (en) * 2020-12-03 2022-06-09 (주)에스디생명공학 Antitussive and mucoactive composition comprising extract of hibiscus syriacus l. as active ingredient

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Application publication date: 20160706