CN105726566A - Hemodialysis condensate capable of being used online - Google Patents
Hemodialysis condensate capable of being used online Download PDFInfo
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- CN105726566A CN105726566A CN201610178458.5A CN201610178458A CN105726566A CN 105726566 A CN105726566 A CN 105726566A CN 201610178458 A CN201610178458 A CN 201610178458A CN 105726566 A CN105726566 A CN 105726566A
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- dry powder
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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Abstract
The invention relates to a hemodialysis condensate capable of being used online. The hemodialysis condensate consists of an acid concentrated solution, sodium chloride dry powder and sodium hydrogen carbonate dry powder which are sub-packaged, wherein the volume mass ratio of the acid concentrated solution to the sodium chloride dry powder to the sodium hydrogen carbonate dry powder is 1L:1300g:650g; the acid concentrated solution consists of 0-59.64g/L potassium chloride, 36.75-51.46g/L calcium chloride, 20.33-30.50g/L magnesium chloride and 24.02-48.04g/L glacial acetic acid; the sodium chloride dry powder only contains one component namely sodium chloride; and the sodium hydrogen carbonate dry powder also only contains one component namely sodium hydrogen carbonate. The hemodialysis condensate provided by the invention is convenient to carry and use, thereby reducing manual labor of medical staffs; the hemodialysis condensate can be closely connected with a dialysis machine to avoid the trouble of solution preparation by the medical staffs and avoid pollution caused by exposure, an overlong delivery pipeline or irregular preparation, thereby ensuring the accuracy and stability of the total ion concentration of dialysis, and improving the dialysis quality and patient safety; and meanwhile, personalized dialysis is realized.
Description
Technical field
The present invention relates to a kind of hemodialysis concentrate, be specifically related to a kind of can the hemodialysis concentrate of online online use.
Background technology
Uraemic patients is because of renal failure, the urotoxin should discharged cannot be excreted by kidney, so that internal uremic concentration raises, and by hemodialysis just can by sordid in health, guide containing the blood that uremic is high, through hemodialyzer, filtering some uremics, that then these dialysed again, clean blood is sent back to internal.After this process, uremic in the patient reduces, and symptom alleviates naturally.Owing to dialysate volumes is relatively larger, for convenient transport, generally each for dialysis solution component is mixed and made into concentrate, before using after hospital, is diluted to normal dialysis solution again.
Hemodialysis concentrate refers to the concentrate for the process such as hemodialysis, filtration, the metabolic waste in blood when its effect is to take away dialysis, and regulates plasma electrolyte disorder and acid-base balance.When patient carries out hemodialysis, hemodialysis Concentrate flow is in the offside of dialyser semipermeable membrane blood samples of patients, by physical processes such as convection current, disperse, absorption and ultrafiltration, swap with the material in blood samples of patients, improve the composition in blood samples of patients, correct electrolyte imbalance, acid base imbalance, effectively remove interior metabolism product toxin.
At present, conventional hemodialysis concentrate includes hemodialysis concentrated solution and two kinds of forms of dry-powder-type concentrate.Hemodialysis concentrated solution is that one contains the electrolytical liquid of high concentration, and it is added after water-dialyzing is diluted to dialysis solution can be used in the ratio specified, and its solute component is needed to be determined by clinic.Dry-powder-type concentrate is to be mixed by a certain percentage by one or more solid chemical substance, needs to add water-dialyzing in use and is dissolved into concentrated solution, and its solute component and ion concentration are needed to determine by clinic.Hemodialysis concentrated solution is restricted owing to volume is big, it is inconvenient to transport and store in use, and the problems such as each component is uneven, content accuracy is low usually occurs in dry-powder-type concentrate.
Along with developing rapidly of science and technology, at present, the form of A concentrated solution B dry powder taked by the hemodialysis concentrate of many medical institutions.Wherein, B dry powder is independent subpackage, can online online time use, packaging is exquisite, carrying cost is low for it, and reduces the probability of bicarbonate concentrated solution bacteria breed.But, containing substantial amounts of sodium chloride component in traditional A concentrated solution, make A concentrated solution volume more greatly, not portable, and need medical worker to prepare in advance in use, owing to exposing, conveyance conduit is long or nonstandard preparation and easily cause pollution and breed bacteria.Thus, if able to a kind of individually packaging of research and development, can online online time preparation use A concentrated solution, it is made to have the advantages such as packaging is exquisite, easy and simple to handle, composition proportion is excellent concurrently, and can be different to the demand of ion concentration each in dialysis solution according to patient, improving mass of dialysate by adjustment A concentrated solution intermediate ion concentration and realize personalized dialysis, this is for ensureing that patient safety and raising medical personnel's work efficiency are necessary.
Summary of the invention
It is an object of the invention to for the deficiencies in the prior art, it is provided that a kind of can the hemodialysis concentrate of online online use, its carrying cost is low, it is easy to operate to use and safety is high.
It is an object of the invention to be achieved through the following technical solutions:
A kind of can the hemodialysis concentrate of online online use, be made up of the acid concentrated solution of subpackage, sodium chloride dry powder and sodium bicarbonate powder；
The volume mass ratio of described acid concentrated solution, sodium chloride dry powder and sodium bicarbonate powder is: 1L:1300g:650g；
Described acid concentrated solution is made up of the glacial acetic acid of 0～59.64g/L potassium chloride, 36.75～51.46g/L calcium chloride, 20.33～30.50g/L magnesium chloride and 24.02～48.04g/L；
Described sodium chloride dry powder contains only sodium chloride one component；
Described sodium bicarbonate powder contains only sodium bicarbonate one component.
Preferably, described acid concentrated solution is made up of 29.82g/L potassium chloride, 36.75g/L calcium chloride, 20.33g/L magnesium chloride and 36.03g/L glacial acetic acid.
Described acid concentrated solution is made up of 29.82g/L potassium chloride, 44.11g/L calcium chloride, 20.33g/L magnesium chloride and 36.03g/L glacial acetic acid.
Described acid concentrated solution is made up of 29.82g/L potassium chloride, 51.46g/L calcium chloride, 20.33g/L magnesium chloride and 36.03g/L glacial acetic acid.
The present invention can the method for online online preparation dialysis solution of hemodialysis concentrate of online online use, comprise the following steps:
A, acid concentrated solution installation kit is arranged on the dialysis machine being provided with the fixing device of acid concentrated solution installation kit；
B, will be equipped with the dry powder bucket of sodium chloride dry powder and sodium bicarbonate powder and be separately mounted to be provided with on the dialysis machine of the fixing device of dry powder bucket, then dialysis machine inputs water for dialysis in each dry powder bucket of trend, and sodium chloride dry powder and sodium bicarbonate powder are dissolved into saturated solution by water for dialysis respectively；
C, last, the saturated solution of the acid concentrated solution in step a and b step gained is mixed in the ratio of 1:200, obtains required dialysis solution.
In step a, the acid concentrated solution in described installation kit is 0～59.64g/L potassium chloride, 36.75～51.46g/L calcium chloride, 20.33～30.50g/L magnesium chloride and 24.02～48.04g/L glacial acetic acid composition.
In step b, described water for dialysis refers to the pure water through reverse-osmosis treated, its standard needing to meet YY0572-2005 hemodialysis water.
Acid concentrated solution of the present invention, sodium chloride dry powder and sodium bicarbonate powder in dress, owing to every part has specific exquisite packing material in dress, greatly reduce small product size by the particular envelope thing matched with dialysis machine.
The invention have the benefit that
1, due to by the maximum sodium chloride Component seperation of accounting in tradition A concentrated solution out, and it is designed to the packaging of exquisiteness, it is achieved thereby that utilize dialysis machine to dissolve voluntarily online, improves the stability of its dissolution velocity and ion concentration；
2, the volume of acid concentrated solution is only the 1/5 of tradition dialysis A concentrated solution volume, and sodium bicarbonate powder is only the 1/7 of traditional B dry powder volume, greatly reduces floor space when product is deposited, and carry, easy to use, decrease the physical work of medical worker；
3, three ingredients of this product are all directly airtight with dialysis machine being connected, eliminate the trouble of medical worker's dosing voluntarily, and avoid owing to exposing, conveyance conduit is long or nonstandard preparation and the pollution that causes, ensure that the Stability and veracity of overall ion concentration of dialysing, improve dialysis quality and patient safety.
4, according to the ion Demand Design of patient self go out multiple can the hemodialysis concentrate of online online use, it is achieved that personalized dialysis.
Detailed description of the invention
Because the body constitution of every dialysis patient differs, in dialysis procedure, patient is also different to the demand of dialysis solution intermediate ion concentration.For realizing personalized dialysis, the present invention according to the Demand Design of patient self go out several can the hemodialysis concentrate of online online use, being K2.0Ca1.25 type, K2.0Ca1.50 type and K2.0Ca1.75 type hemodialysis concentrate respectively, it is distinctive in that the difference of final calcium ion concentration.Such as, needs of patients Low calcium dialysis, it is possible to option and installment K2.0Ca1.25 type hemodialysis concentrate；Need high calcium to dialyse, then can option and installment K2.0Ca1.75 type hemodialysis concentrate.It addition, the present invention's can in the hemodialysis concentrate of online online use outside deliming ion, other ion concentrations are also can go to select according to patient self, here do not enumerate.
Embodiment 1
Composition and the proportioning of K2.0Ca1.25 type hemodialysis concentrate are as follows:
A kind of can the hemodialysis concentrate of online online use, be made up of the acid concentrated solution of subpackage, sodium chloride dry powder and sodium bicarbonate powder；
The volume mass ratio of described acid concentrated solution, sodium chloride dry powder and sodium bicarbonate powder is: 1L:1300g:650g；
Described acid concentrated solution is made up of 29.82g/L potassium chloride, 36.75g/L calcium chloride, 20.33g/L magnesium chloride and 36.03g/L glacial acetic acid；
Described sodium chloride dry powder contains only sodium chloride one component；
Described sodium bicarbonate powder also contains only sodium bicarbonate one component.
The method of the online online preparation dialysis solution of K2.0Ca1.25 type hemodialysis concentrate, comprises the following steps:
A, acid concentrated solution installation kit is arranged on the dialysis machine being provided with the fixing device of acid concentrated solution installation kit；
B, will be equipped with the dry powder bucket of 1300g sodium chloride dry powder and 650g sodium bicarbonate powder and be separately mounted to be provided with on the dialysis machine of the fixing device of dry powder bucket, then dialysis machine inputs water for dialysis in each dry powder bucket of trend, and sodium chloride dry powder and sodium bicarbonate powder are dissolved into saturated solution by water for dialysis respectively；
C, last, the saturated solution of the acid concentrated solution in step a and b step gained is mixed in the ratio of 1:200, obtains required dialysis solution.
In step a, the acid concentrated solution in described installation kit is made up of 29.82g/L potassium chloride, 36.75g/L calcium chloride, 20.33g/L magnesium chloride and 36.03g/L glacial acetic acid.
In step b, described water for dialysis refers to the pure water through reverse-osmosis treated, its standard needing to meet YY0572-2005 hemodialysis water.
Embodiment 2
Composition and the proportioning of K2.0Ca1.50 type hemodialysis concentrate are as follows:
A kind of can the hemodialysis concentrate of online online use, be made up of the acid concentrated solution of subpackage, sodium chloride dry powder and sodium bicarbonate powder；
The volume mass ratio of described acid concentrated solution, sodium chloride dry powder and sodium bicarbonate powder is: 1L:1300g:650g；
Described acid concentrated solution is made up of 29.82g/L potassium chloride, 44.11g/L calcium chloride, 20.33g/L magnesium chloride and 36.03g/L glacial acetic acid；
Described sodium chloride dry powder contains only sodium chloride one component；
Described sodium bicarbonate powder also contains only sodium bicarbonate one component.
The method of the online online preparation dialysis solution of K2.0Ca1.50 type hemodialysis concentrate, comprises the following steps:
A, acid concentrated solution installation kit is arranged on the dialysis machine being provided with the fixing device of acid concentrated solution installation kit；
B, will be equipped with the dry powder bucket of 1300g sodium chloride dry powder and 650g sodium bicarbonate powder and be separately mounted to be provided with on the dialysis machine of the fixing device of dry powder bucket, then dialysis machine inputs water for dialysis in each dry powder bucket of trend, and sodium chloride dry powder and sodium bicarbonate powder are dissolved into saturated solution by water for dialysis respectively；
C, last, the saturated solution of the acid concentrated solution in step a and b step gained is mixed in the ratio of 1:200, obtains required dialysis solution.
In step a, the acid concentrated solution in described installation kit is made up of 29.82g/L potassium chloride, 44.11g/L calcium chloride, 20.33g/L magnesium chloride and 36.03g/L glacial acetic acid.
In step b, described water for dialysis refers to the pure water through reverse-osmosis treated, its standard needing to meet YY0572-2005 hemodialysis water.
Embodiment 3
Composition and the proportioning of K2.0Ca1.75 type hemodialysis concentrate are as follows:
A kind of can the hemodialysis concentrate of online online use, be made up of the acid concentrated solution of subpackage, sodium chloride dry powder and sodium bicarbonate powder；
The volume mass ratio of described acid concentrated solution, sodium chloride dry powder and sodium bicarbonate powder is, 1L:1300g:650g；
Described acid concentrated solution is made up of 29.82g/L potassium chloride, 51.46g/L calcium chloride, 20.33g/L magnesium chloride and 36.03g/L glacial acetic acid；
Described sodium chloride dry powder contains only sodium chloride one component；
Described sodium bicarbonate powder also contains only sodium bicarbonate one component.
The method of the online online preparation dialysis solution of K2.0Ca1.75 type hemodialysis concentrate, comprises the following steps:
A, acid concentrated solution installation kit is arranged on the dialysis machine being provided with the fixing device of acid concentrated solution installation kit；
B, will be equipped with the dry powder bucket of 1300g sodium chloride dry powder and 650g sodium bicarbonate powder and be separately mounted to be provided with on the dialysis machine of the fixing device of dry powder bucket, then dialysis machine inputs water for dialysis in each dry powder bucket of trend, and sodium chloride dry powder and sodium bicarbonate powder are dissolved into saturated solution by water for dialysis respectively；
C, last, the saturated solution of the acid concentrated solution in step a and b step gained is mixed in the ratio of 1:200, obtains required dialysis solution.
In step a, the acid concentrated solution in described installation kit is made up of 29.82g/L potassium chloride, 51.46g/L calcium chloride, 20.33g/L magnesium chloride and 36.03g/L glacial acetic acid.
In step b, described water for dialysis refers to the pure water through reverse-osmosis treated, its standard needing to meet YY0572-2005 hemodialysis water.
The present invention is prepared the final ion concentration of hemodialysis concentrate obtained and pH value is as shown in the table:
Three kinds of final ion concentrations of hemodialysis concentrate and pH value are extremely suitable for human body, and safety is high.
Claims (4)
1. one kind can the hemodialysis concentrate of online online use, it is characterised in that: be made up of the acid concentrated solution of subpackage, sodium chloride dry powder and sodium bicarbonate powder；
The volume mass ratio of described acid concentrated solution, sodium chloride dry powder and sodium bicarbonate powder is: 1L:1300g:650g；
Described acid concentrated solution is made up of the glacial acetic acid of 0～59.64g/L potassium chloride, 36.75～51.46g/L calcium chloride, 20.33～30.50g/L magnesium chloride and 24.02～48.04g/L；
Described sodium chloride dry powder contains only sodium chloride one component；
Described sodium bicarbonate powder contains only sodium bicarbonate one component.
2. according to claim 1 a kind of can the hemodialysis concentrate of online online use, it is characterised in that: described acid concentrated solution is made up of 29.82g/L potassium chloride, 36.75g/L calcium chloride, 20.33g/L magnesium chloride and 36.03g/L glacial acetic acid.
3. according to claim 1 a kind of can the hemodialysis concentrate of online online use, it is characterised in that: described acid concentrated solution is made up of 29.82g/L potassium chloride, 44.11g/L calcium chloride, 20.33g/L magnesium chloride and 36.03g/L glacial acetic acid.
4. according to claim 1 a kind of can the hemodialysis concentrate of online online use, it is characterised in that: described acid concentrated solution is made up of 29.82g/L potassium chloride, 51.46g/L calcium chloride, 20.33g/L magnesium chloride and 36.03g/L glacial acetic acid.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610178458.5A CN105726566A (en) | 2016-03-25 | 2016-03-25 | Hemodialysis condensate capable of being used online |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610178458.5A CN105726566A (en) | 2016-03-25 | 2016-03-25 | Hemodialysis condensate capable of being used online |
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| CN105726566A true CN105726566A (en) | 2016-07-06 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109330990A (en) * | 2018-10-30 | 2019-02-15 | 吉林省富生医疗器械有限公司 | A kind of haemodialysis B powder of high-dissolvability and preparation method thereof |
| CN109982684A (en) * | 2016-11-21 | 2019-07-05 | 费森尤斯医疗护理德国有限责任公司 | For manufacturing the method, equipment and the tank that are used for the liquid acidic concentrate of haemodialysis control unit |
| CN113827800A (en) * | 2021-10-26 | 2021-12-24 | 常州华岳微创医疗器械有限公司 | Ultrapure hemodialysis concentrated solution and preparation process thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101933939A (en) * | 2010-09-01 | 2011-01-05 | 刘思波 | Malic acid bicarbonate external hemodialysis agent |
| CN102038978A (en) * | 2009-10-20 | 2011-05-04 | 上海和亭商贸有限公司 | Hemodialysis concentrate |
-
2016
- 2016-03-25 CN CN201610178458.5A patent/CN105726566A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102038978A (en) * | 2009-10-20 | 2011-05-04 | 上海和亭商贸有限公司 | Hemodialysis concentrate |
| CN101933939A (en) * | 2010-09-01 | 2011-01-05 | 刘思波 | Malic acid bicarbonate external hemodialysis agent |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109982684A (en) * | 2016-11-21 | 2019-07-05 | 费森尤斯医疗护理德国有限责任公司 | For manufacturing the method, equipment and the tank that are used for the liquid acidic concentrate of haemodialysis control unit |
| CN109982684B (en) * | 2016-11-21 | 2022-04-08 | 费森尤斯医疗护理德国有限责任公司 | Method, apparatus and tank for producing a liquid acidic concentrate for hemodialysis machines |
| CN109330990A (en) * | 2018-10-30 | 2019-02-15 | 吉林省富生医疗器械有限公司 | A kind of haemodialysis B powder of high-dissolvability and preparation method thereof |
| CN113827800A (en) * | 2021-10-26 | 2021-12-24 | 常州华岳微创医疗器械有限公司 | Ultrapure hemodialysis concentrated solution and preparation process thereof |
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Application publication date: 20160706 |
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