CN113827800A - Ultrapure hemodialysis concentrated solution and preparation process thereof - Google Patents
Ultrapure hemodialysis concentrated solution and preparation process thereof Download PDFInfo
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- 238000001631 haemodialysis Methods 0.000 title claims abstract description 48
- 230000000322 hemodialysis Effects 0.000 title claims abstract description 48
- 238000002360 preparation method Methods 0.000 title claims abstract description 33
- 239000007788 liquid Substances 0.000 claims abstract description 44
- 238000003860 storage Methods 0.000 claims abstract description 29
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 27
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 26
- 230000001954 sterilising effect Effects 0.000 claims abstract description 23
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims abstract description 22
- 239000000463 material Substances 0.000 claims abstract description 22
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 claims abstract description 20
- 238000000502 dialysis Methods 0.000 claims abstract description 20
- 238000001914 filtration Methods 0.000 claims abstract description 16
- 239000001569 carbon dioxide Substances 0.000 claims abstract description 11
- 229910002092 carbon dioxide Inorganic materials 0.000 claims abstract description 11
- 239000000243 solution Substances 0.000 claims description 64
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 22
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 18
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 14
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 13
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims description 12
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 12
- 238000001223 reverse osmosis Methods 0.000 claims description 10
- 239000011780 sodium chloride Substances 0.000 claims description 9
- 239000007864 aqueous solution Substances 0.000 claims description 8
- 239000012141 concentrate Substances 0.000 claims description 8
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 7
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 7
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 6
- 229960000583 acetic acid Drugs 0.000 claims description 6
- 239000001110 calcium chloride Substances 0.000 claims description 6
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 6
- 229910001629 magnesium chloride Inorganic materials 0.000 claims description 6
- 239000011259 mixed solution Substances 0.000 claims description 6
- 239000001103 potassium chloride Substances 0.000 claims description 6
- 235000011164 potassium chloride Nutrition 0.000 claims description 6
- 238000001179 sorption measurement Methods 0.000 claims description 6
- 239000012362 glacial acetic acid Substances 0.000 claims description 5
- 239000012528 membrane Substances 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 239000011148 porous material Substances 0.000 claims description 3
- 238000009287 sand filtration Methods 0.000 claims description 2
- 238000001471 micro-filtration Methods 0.000 claims 2
- 241000894006 Bacteria Species 0.000 abstract description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000004576 sand Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 208000012639 Balance disease Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1654—Dialysates therefor
- A61M1/1656—Apparatus for preparing dialysates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/168—Sterilisation or cleaning before or after use
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F9/00—Multistage treatment of water, waste water or sewage
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/001—Processes for the treatment of water whereby the filtration technique is of importance
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/28—Treatment of water, waste water, or sewage by sorption
- C02F1/283—Treatment of water, waste water, or sewage by sorption using coal, charred products, or inorganic mixtures containing them
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/30—Treatment of water, waste water, or sewage by irradiation
- C02F1/32—Treatment of water, waste water, or sewage by irradiation with ultraviolet light
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/44—Treatment of water, waste water, or sewage by dialysis, osmosis or reverse osmosis
- C02F1/441—Treatment of water, waste water, or sewage by dialysis, osmosis or reverse osmosis by reverse osmosis
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F5/00—Softening water; Preventing scale; Adding scale preventatives or scale removers to water, e.g. adding sequestering agents
Abstract
The invention discloses an ultrapure hemodialysis concentrated solution and a preparation process thereof, comprising the following steps: preparing materials such as a liquid preparation tank, a connecting pipe, a filter and the like, firstly carrying out disinfection and sterilization treatment on the materials, then injecting dialysis water into the liquid preparation tank, and simultaneously taking corresponding hemodialysis concentrated A liquid and hemodialysis concentrated B liquid according to a certain proportion; step two: conveying the solution obtained in the step one to a liquid storage tank through a connecting pipe, and simultaneously setting carbon dioxide release at the bottom of the liquid storage tank, and performing the step three: inputting the solution obtained in the step two into the solution by ozone generated by an ozone generator; step four: filtering the solution obtained in the third step by using a precision filter; step five: the filtered solution is transferred to a storage bucket through a connecting pipe, and the storage bucket is pressurized. The ultrapure hemodialysis concentrated solution and the preparation process thereof reduce initial pollution bacteria in the concentrated solution, prolong the storage period, better ensure the quality of products and ensure the use safety of patients.
Description
Technical Field
The invention relates to the technical field of hemodialysis concentrated solution, in particular to ultrapure hemodialysis concentrated solution and a preparation process thereof.
Background
The hemodialysis concentrated solution comprises a concentrated solution A and a concentrated solution B, wherein the concentrated solution A mainly comprises sodium chloride, potassium chloride, calcium chloride, magnesium chloride, acetic acid and purified water, and the concentrated solution B comprises sodium bicarbonate and purified water. The A concentrated solution and the B concentrated solution are matched to form a dialyzate in hemodialysis, and the dialyzate mainly has the functions of correcting electrolyte and acid-base balance disorder of a dialysis patient and removing metabolic wastes in a body.
During hemodialysis, substances are exchanged between the dialysate and the blood through the dialyzer filter membrane, and some low molecular substances can freely pass through the dialyzer filter membrane, enter the dialysate from the blood or enter the blood from the dialysate. Therefore, the quality of the dialyzate directly influences the quality of hemodialysis, so that the life quality of a dialysis patient is influenced, the traditional process for preparing the hemodialysis concentrated solution has short preservation time, and bacteria are easily generated. Therefore, we improve the technology and propose an ultra-pure hemodialysis concentrated solution and a preparation technology.
Disclosure of Invention
In order to solve the technical problems, the invention provides the following technical scheme:
the invention relates to an ultra-pure hemodialysis concentrated solution, which comprises a hemodialysis concentrated solution A and a hemodialysis concentrated solution B, wherein the content of each component of the hemodialysis concentrated solution A is 9.56-16.48g/L of potassium chloride, 17-19.80g/L of magnesium chloride, 55.45-90.55g/L of sodium chloride, 2.56-8.50g/L, pH of calcium chloride and 14.25-26.35g/L of glacial acetic acid aqueous solution.
As a preferred technical scheme of the invention, the hemodialysis concentrated B solution comprises the following components in percentage by weight: 12.80-18.50g/L sodium bicarbonate or 8.25-28.55g/L sodium bicarbonate and 4.35-25.55g/L sodium chloride aqueous solution.
A preparation process of an ultrapure hemodialysis concentrated solution comprises the following steps:
the method comprises the following steps: preparing materials such as a liquid preparation tank, a connecting pipe, a filter and the like, firstly carrying out disinfection and sterilization treatment on the materials, then injecting dialysis water into the liquid preparation tank, simultaneously taking corresponding hemodialysis concentrated solution A and hemodialysis concentrated solution B according to a certain proportion, and putting the materials into the liquid preparation tank;
step two: conveying the solution obtained in the step one to a liquid storage tank through a connecting pipe, and simultaneously setting carbon dioxide release at the bottom of the liquid storage tank to obtain a mixed solution;
step three: inputting the ozone generated by the ozone generator into the solution obtained in the step two, wherein the concentration of the ozone is 0.04-0.07 mg/L;
step four: filtering the solution obtained in the third step by using a precision filter;
step five: the filtered solution is transferred to a storage bucket through a connecting pipe, and the storage bucket is pressurized.
In the first step, the solution in the solution preparation tank is stirred and simultaneously heated to a certain temperature of 35-40 ℃.
As a preferred technical scheme of the invention, the first step sterilization temperature is 100-130 ℃, and the sterilization time is 30-45 min.
As a preferred technical scheme of the invention, the dialysis water obtained in the first step is prepared by a sand filter, softening, activated carbon adsorption and reverse osmosis, the reverse osmosis water generated by filtration in the first step can be used as dialysis water after being irradiated by ultraviolet rays, and the water temperature is controlled to be 30-45 ℃.
As a preferable technical scheme of the invention, the time for introducing the carbon dioxide in the second step is 25-45 min.
In a preferred embodiment of the present invention, the precision filter in the fourth step is a 0.22 μm sterilizing grade filter.
As a preferred technical scheme of the invention, when the precision filter is used in the fourth step, the circulation is repeated three times, and the filtering pore diameter of the sterilizing grade filter adopted in the three times of circulation is 0.22 micron, 0.15 micron and 0.10 micron.
As a preferable technical scheme of the invention, the adsorption pressure of the activated carbon is 0.20MPa-0.35MPa, and the particle size of the activated carbon is 20-80 μm.
The invention has the beneficial effects that:
the method comprises the following steps: preparing materials such as a liquid preparation tank, a connecting pipe, a filter and the like, firstly carrying out disinfection and sterilization treatment on the materials, then injecting dialysis water into the liquid preparation tank, simultaneously taking corresponding hemodialysis concentrated solution A and hemodialysis concentrated solution B according to a certain proportion, and putting the materials into the liquid preparation tank; step two: conveying the solution obtained in the step one to a liquid storage tank through a connecting pipe, and simultaneously setting carbon dioxide release at the bottom of the liquid storage tank to obtain a mixed solution; step three: inputting the ozone generated by the ozone generator into the solution obtained in the step two, wherein the concentration of the ozone is 0.04-0.07 mg/L; step four: filtering the solution obtained in the third step by using a precision filter; step five: the filtered solution is conveyed into the storage barrel through the connecting pipe, and the storage barrel is pressurized to obtain the hemodialysis concentrated solution, so that the life quality of a patient undergoing maintenance dialysis is improved, the service life is prolonged, the bacterial infection is reduced, the accumulation of harmful substances in the body is avoided, and the life span of the patient undergoing maintenance dialysis is prolonged.
Drawings
The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the principles of the invention and not to limit the invention. In the drawings:
figure 1 is a method step diagram of an ultrapure hemodialysis concentrate and process of making the same of the present invention.
Detailed Description
The preferred embodiments of the present invention will be described in conjunction with the accompanying drawings, and it will be understood that they are described herein for the purpose of illustration and explanation and not limitation.
Example (b): as shown in figure 1, the ultrapure hemodialysis concentrate comprises a hemodialysis concentrate A liquid and a hemodialysis concentrate B liquid, wherein the content of each component of the hemodialysis concentrate A liquid is 9.56-16.48g/L of potassium chloride, 17-19.80g/L of magnesium chloride, 55.45-90.55g/L of sodium chloride, 2.56-8.50g/L, pH of calcium chloride, 9.6-12.5g/L of a value regulator and 14.25-26.35g/L of a glacial acetic acid aqueous solution.
Wherein, the hemodialysis concentrated solution B comprises the following components in percentage by weight: 12.80-18.50g/L sodium bicarbonate or 8.25-28.55g/L sodium bicarbonate and 4.35-25.55g/L sodium chloride aqueous solution.
A preparation process of an ultrapure hemodialysis concentrated solution comprises the following steps:
the method comprises the following steps: preparing materials such as a liquid preparation tank, a connecting pipe, a filter and the like, firstly carrying out disinfection and sterilization treatment on the materials, then injecting dialysis water into the liquid preparation tank, simultaneously taking corresponding hemodialysis concentrated solution A and hemodialysis concentrated solution B according to a certain proportion, and putting the materials into the liquid preparation tank;
step two: conveying the solution obtained in the step one to a liquid storage tank through a connecting pipe, and simultaneously setting carbon dioxide release at the bottom of the liquid storage tank to obtain a mixed solution;
step three: inputting the ozone generated by the ozone generator into the solution obtained in the step two, wherein the concentration of the ozone is 0.04-0.07 mg/L;
step four: filtering the solution obtained in the third step by using a precision filter;
step five: the filtered solution is transferred to a storage bucket through a connecting pipe, and the storage bucket is pressurized.
In the first step, the solution in the liquid preparation tank is stirred and is subjected to certain heating treatment at the temperature of 35-40 ℃, and the solution is quickly dissolved by heating operation.
Wherein the sterilization temperature in the first step is 100-.
The dialysis water obtained in the first step is obtained through sand filtration, softening, activated carbon adsorption and reverse osmosis, the reverse osmosis water generated through filtration in the first step can be used as dialysis water after being irradiated by ultraviolet rays, and the water temperature is controlled to be 30-45 ℃.
And C, introducing carbon dioxide for 25-45 min, wherein the breeding of bacteria and viruses can be effectively inhibited by introducing the carbon dioxide.
Wherein the precision filter in the fourth step is a 0.22 micron sterilizing grade filter, and the precision filter can be used for carrying out more precise filtering operation.
Wherein, when the precision filter is used in the fourth step, the circulation is repeated for three times, and the filtering pore diameter of the sterilization grade filter adopted in the third circulation is 0.22 micron, 0.15 micron and 0.10 micron.
Wherein the adsorption pressure of the activated carbon is 0.20MPa-0.35MPa, and the particle size of the activated carbon is 20-80 μm.
The working principle is as follows:
the first embodiment is as follows: the method comprises the following steps: preparing materials such as a liquid preparation tank, a connecting pipe, a filter and the like, firstly carrying out disinfection and sterilization treatment on the materials, then injecting dialysis water into the liquid preparation tank, simultaneously taking corresponding hemodialysis concentrated A liquid and hemodialysis concentrated B liquid according to a certain proportion, taking 9.56-16.48g/L of potassium chloride, 17-19.80g/L of magnesium chloride, 55.45-90.55g/L of sodium chloride, 2.56-8.50g/L, pH value regulator 9.6-12.5g/L of calcium chloride and 4.35-25.55g/L of glacial acetic acid aqueous solution to form the materials, putting the materials into the liquid preparation tank, wherein the sterilization temperature is 100-130 ℃, the sterilization time is 30-45 min, the dialyzed water passes through a sand filter, and the filter, Softening, adsorbing by activated carbon and reverse osmosis, wherein the reverse osmosis water generated by filtration in the steps can be used as dialysis water after being irradiated by ultraviolet rays; step two: conveying the solution obtained in the step one to a liquid storage tank through a connecting pipe, and simultaneously setting carbon dioxide release at the bottom of the liquid storage tank to obtain a mixed solution; step three: inputting the ozone generated by the ozone generator into the solution obtained in the step two, wherein the concentration of the ozone is 0.04-0.07 mg/L; step four: filtering the solution obtained in the third step by using a precision filter, wherein the precision filter is a 0.22 micron sterilization grade filter; step five: conveying the filtered solution into a storage barrel through a connecting pipe, and pressurizing the storage barrel;
example two: the method comprises the following steps: preparing materials such as a liquid preparation tank, a connecting pipe, a filter and the like, firstly carrying out disinfection and sterilization treatment on the materials, then injecting dialysis water into the liquid preparation tank, simultaneously taking corresponding hemodialysis concentrated A liquid and hemodialysis concentrated B liquid according to a certain proportion, taking 13.56-20.48g/L of potassium chloride, 21-23.80g/L of magnesium chloride, 59.45-94.55g/L of sodium chloride, 6.56-12.50g/L, pH value regulator, 13.6-16.5g/L of calcium chloride and 8.35-29.55g/L of glacial acetic acid aqueous solution to form the materials, putting the materials into the liquid preparation tank, wherein the sterilization temperature is 130-150 ℃, the sterilization time is 40-60 min, the dialysis water passes through a sand filter, and the filter, Softening, adsorbing by activated carbon and reverse osmosis, wherein the reverse osmosis water generated by filtration in the steps can be used as dialysis water after being irradiated by ultraviolet rays; step two: conveying the solution obtained in the step one to a liquid storage tank through a connecting pipe, and simultaneously setting carbon dioxide release at the bottom of the liquid storage tank to obtain a mixed solution; step three: inputting the ozone generated by the ozone generator into the solution obtained in the step two, wherein the concentration of the ozone is 0.04-0.07 mg/L; step four: filtering the solution obtained in the third step by using a precision filter, wherein the precision filter is a 0.22 micron sterilization grade filter; step five: delivering the filtered solution to a storage barrel through a connecting pipe, and pressurizing the storage barrel
Finally, it should be noted that: in the description of the present invention, it should be noted that the terms "vertical", "upper", "lower", "horizontal", and the like indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience of describing the present invention and simplifying the description, but do not indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the present invention.
In the description of the present invention, it should also be noted that, unless otherwise explicitly specified or limited, the terms "disposed," "mounted," "connected," and "connected" are to be construed broadly and may, for example, be fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.
Although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. An ultra-pure hemodialysis concentrated solution comprises a hemodialysis concentrated solution A and a hemodialysis concentrated solution B, and is characterized in that the content of each component of the hemodialysis concentrated solution A is 9.56-16.48g/L of potassium chloride, 17-19.80g/L of magnesium chloride, 55.45-90.55g/L of sodium chloride, 2.56-8.50g/L, pH of calcium chloride, 9.6-12.5g/L of a value regulator and 14.25-26.35g/L of a glacial acetic acid aqueous solution.
2. The hemodialysis concentrate of claim 1, wherein the hemodialysis concentrate B comprises the following components in parts by weight: 12.80-18.50g/L sodium bicarbonate or 8.25-28.55g/L sodium bicarbonate and 4.35-25.55g/L sodium chloride aqueous solution.
3. A preparation process of an ultrapure hemodialysis concentrated solution is characterized by comprising the following steps:
the method comprises the following steps: preparing materials such as a liquid preparation tank, a connecting pipe, a filter and the like, firstly carrying out disinfection and sterilization treatment on the materials, then injecting dialysis water into the liquid preparation tank, simultaneously taking corresponding hemodialysis concentrated solution A and hemodialysis concentrated solution B according to a certain proportion, and putting the materials into the liquid preparation tank;
step two: conveying the solution obtained in the step one to a liquid storage tank through a connecting pipe, and simultaneously setting carbon dioxide release at the bottom of the liquid storage tank to obtain a mixed solution;
step three: inputting the ozone generated by the ozone generator into the solution obtained in the step two, wherein the concentration of the ozone is 0.04-0.07 mg/L;
step four: filtering the solution obtained in the third step by using a precision filter;
step five: the filtered solution is transferred to a storage bucket through a connecting pipe, and the storage bucket is pressurized.
4. The process of claim 3, wherein in the first step, the solution in the solution preparation tank is stirred and heated at a temperature of 35-40 ℃.
5. The ultra-pure hemodialysis concentrate and the preparation process thereof as claimed in claim 1, wherein the first sterilization temperature is 100 ℃ and the sterilization time is 30min to 45 min.
6. The process of claim 3, wherein the dialysis water obtained in the first step is subjected to sand filtration, softening, activated carbon adsorption and reverse osmosis, and the reverse osmosis water obtained by filtration in the first step can be used as dialysis water after being irradiated by ultraviolet rays, and the water temperature is controlled to be 30-45 ℃.
7. The process of claim 3, wherein the carbon dioxide is introduced for a period of about 25 to 45 minutes.
8. The process of claim 3, wherein the ultrafilter of step four is a 0.22 micron sterilizing grade filter.
9. The process of claim 3, wherein the microfiltration filter used in step four is repeated three times, and wherein the filtration pore size of the microfiltration membrane used in the three cycles is 0.22 microns, 0.15 microns or 0.10 microns.
10. The process of claim 6, wherein the pressure of the activated carbon adsorption is 0.20MPa to 0.35MPa, and the particle size of the activated carbon is 20 to 80 μm.
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| CN105726566A (en) * | 2016-03-25 | 2016-07-06 | 吉林省富生医疗器械有限公司 | Hemodialysis condensate capable of being used online |
| CN108066356A (en) * | 2018-02-05 | 2018-05-25 | 济泰（上海）生物科技有限公司 | A kind of haemodialysis concentrate |
| CN110917422A (en) * | 2019-12-05 | 2020-03-27 | 长春海伯尔生物技术有限责任公司 | Ultrapure hemodialysis concentrated solution and preparation process thereof |
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- 2021-10-26 CN CN202111244990.XA patent/CN113827800A/en active Pending
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| CN102038978A (en) * | 2009-10-20 | 2011-05-04 | 上海和亭商贸有限公司 | Hemodialysis concentrate |
| CN105641764A (en) * | 2015-12-28 | 2016-06-08 | 天津市标准生物制剂有限公司 | Ultra-pure hemodialysis concentrated solution manufacturing system and manufacturing technology |
| CN105726566A (en) * | 2016-03-25 | 2016-07-06 | 吉林省富生医疗器械有限公司 | Hemodialysis condensate capable of being used online |
| CN108066356A (en) * | 2018-02-05 | 2018-05-25 | 济泰（上海）生物科技有限公司 | A kind of haemodialysis concentrate |
| CN110917422A (en) * | 2019-12-05 | 2020-03-27 | 长春海伯尔生物技术有限责任公司 | Ultrapure hemodialysis concentrated solution and preparation process thereof |
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