CN105726156B - Obstructive sleep respiratory disorder disease animal model preparation system - Google Patents
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Abstract
The present invention relates to medic laboratory technology field, more particularly to a kind of obstructive sleep respiratory disorder disease animal model preparation system.The obstructive sleep respiratory disorder disease animal model preparation system, including head-shield and simulation case；The first end of simulation case connects with the inside of the head-shield, and corresponding second end of the simulation case is used to connect source of the gas；The first valve is provided between the simulation case and the source of the gas；The open at one end of the head-shield, and the head-shield is used to be enclosed on purpose animal outside；The opening of the head-shield can be connected with the neck seal of the purpose animal；Stable-pressure device is connected with the simulation case；The stable-pressure device is preset with pressure threshold, for controlling the gas path on-off inside and outside the simulation case.It is an object of the invention to provide a kind of obstructive sleep respiratory disorder disease animal model preparation system, to improve understanding and the treatment to obstructive sleep respiratory disorder disease.
Description
Technical field
The present invention relates to medic laboratory technology field, more particularly to a kind of obstructive sleep respiratory disorder disease animal model
Preparation system.
Background technology
With the development of social and economic condition, medical industry gradually causes the extensive concern of people, and people increasingly pay attention to
The research of sleep associated with disease, substantial amounts of epidemiology statistics show that obstructive sleep respiratory disorder disease is to influence the mankind to sleep
The unfavorable factor of dormancy quality or even health, scholar both domestic and external, which constantly seeks, since the eighties in last century establishes this
The animal model of kind disease, so as to people's understanding, research, treatment obstructive sleep respiratory disorder disease.
In the prior art, intermittent hypoxia animal model is to start the nineties in last century to be progressively employed；It is prepared by such a model
System is to close experimental animal in sealing container, and then interruption gives air or nitrogen on request, is come with this between artificial manufacture
The animal model of breakthrough oxygen.But can completely does not simulate obstructive sleep respiratory disorder disease, the i.e. model to such a model
Two important pathological factors can not be simulated：When respiratory tract obst ruction, second, intake negative-pressure.It cannot be simulated without this two kinds of factors
The pathophysiological process that the mankind are showed when suffering from obstructive sleep respiratory disorder disease, so as to be treatment in the future
True and reliable foundation is provided.
So far suitable animal modeling method is not found, thus is seriously constrained to obstructive sleep respiratory disorder disease
The understanding of disease and treatment.
The content of the invention
It is an object of the invention to provide a kind of obstructive sleep respiratory disorder disease animal model preparation system, to improve
Understanding and treatment to obstructive sleep respiratory disorder disease.
The invention provides a kind of obstructive sleep respiratory disorder disease animal model preparation system, including head-shield and simulation
Case；
The first end of the simulation case connects with the inside of the head-shield, described to simulate the corresponding of case
Second end is used to connect source of the gas；The first valve is provided between the simulation case and the source of the gas；
The open at one end of the head-shield, and the head-shield is used to be enclosed on purpose animal outside；The opening of the head-shield can
It is connected with the neck seal of the purpose animal；
Stable-pressure device is connected with the simulation case；The stable-pressure device is preset with pressure threshold, for controlling
Gas path on-off inside and outside the simulation case.
Further, it is fixedly installed oronasal mask on the head-shield；It is described simulation case by the oronasal mask with
The inside connection of the head-shield；The oronasal mask uses hard material, and the head-shield uses soft material.
Further, the head-shield uses medical grade rubber film or medical plastic film；The oronasal mask uses medical grade rubber
Or medical plastic.
Further, the obstructive sleep respiratory disorder disease animal model preparation system also includes gas pressure control
Device and air-flow opening and closing timer；First valve, air-flow opening and closing timer control with the gas pressure fill respectively
Put electrical connection；
The gas pressure control device is used for the keying for controlling first valve；The air-flow opening and closing timer is used for
Monitor the keying duration of first valve.
Further, first valve includes the first malleation valve and the first negative pressure valve；The first malleation valve,
First negative pressure valve electrically connects with the gas pressure control device respectively；
The first malleation valve is used to connect malleation source of the gas, and first negative pressure valve is used to connect negative pressure source of the gas；
The gas pressure control device is used to control the first malleation valve, first negative pressure valve to open respectively
Close；The air-flow opening and closing timer is used to monitor the first malleation valve, the keying duration of first negative pressure valve respectively.
Further, the obstructive sleep respiratory disorder disease animal model preparation system also include the first air inlet pipe and
Second air inlet pipe；The the second end first end with first air inlet pipe, second air inlet respectively of the simulation case
The first end connection of pipe；
Corresponding second end of first air inlet pipe is connected with the first malleation valve, the phase of second air inlet pipe
The second end answered is connected with first negative pressure valve；
First air inlet pipe is identical with the length of second air inlet pipe.
Further, the malleation source of the gas is constant pressure source or becomes potential source；The negative pressure source of the gas is constant pressure source or transformation
Source.
Further, the simulation case includes the first container tube and second container pipe, first container tube
First end connects with the inside of the head-shield, and corresponding second end of first container tube is used to connect the source of the gas；
The first end of the second container pipe connects with the first end of first container tube, the phase of the second container pipe
The second end answered connects with the second end of first container tube；
The stable-pressure device is arranged on the second container pipe；The pressure threshold is malleation value, negative pressure value or big
Atmospheric pressure value.
Further, the simulation case also includes the 3rd container tube；The first end of 3rd container tube and institute
State the first end connection of the first container tube, corresponding second end of the 3rd container tube and the second end of first container tube
Connection；
The stable-pressure device includes positive valve and negative pressure valve；
The positive valve is arranged on the second container pipe；The second valve is installed with the second container pipe, it is described
Second valve is separately positioned on the positive valve both sides；
The negative pressure valve is arranged in the 3rd container tube；The 3rd valve is installed with 3rd container tube, it is described
3rd valve is separately positioned on the negative pressure valve both sides.
Further, the simulation case also includes the 4th container tube；
The first end of 4th container tube connects with first container tube, and corresponding the second of the 4th container tube
End is open；The 4th valve is installed with 4th container tube.
Obstructive sleep respiratory disorder disease animal model preparation system provided by the invention, including head-shield and simulation container
Device, by simulation case on connect stable-pressure device, using ensure simulate case in air pressure as default malleation,
The pressure threshold of negative pressure or atmospheric pressure；By that will be enclosed on outside head-shield on the head of purpose animal, so that animal prepares system in model
It can both keep natural atmosphere to press autonomous respiration in system, can isolate again in breathing with external environment so that the sky of its suction
Pressure, the oxygen content of gas are controllable, can also make to keep subnormal ambient in model preparation system；Make it effectively simulate sleep to exhale
The scenes such as road interruption obstruction, intake negative-pressure are inhaled, are provided in fact to improve the understanding of obstructive sleep respiratory disorder disease and treatment
Test basis.
Brief description of the drawings
, below will be to specific in order to illustrate more clearly of the specific embodiment of the invention or technical scheme of the prior art
The required accompanying drawing used is briefly described in embodiment or description of the prior art, it should be apparent that, in describing below
Accompanying drawing is some embodiments of the present invention, for those of ordinary skill in the art, before creative work is not paid
Put, other accompanying drawings can also be obtained according to these accompanying drawings.
Fig. 1 is the first knot of obstructive sleep respiratory disorder disease animal model preparation system provided in an embodiment of the present invention
Structure schematic diagram；
Fig. 2 is the second knot of obstructive sleep respiratory disorder disease animal model preparation system provided in an embodiment of the present invention
Structure schematic diagram；
Fig. 3 is the 3rd knot of obstructive sleep respiratory disorder disease animal model preparation system provided in an embodiment of the present invention
Structure schematic diagram.
Reference：
1- head-shields；11- oronasal masks；12- is open；
2- simulates case；The container tubes of 21- first；22- second container pipes；
The valves of 221- second；The container tubes of 23- the 3rd；The valves of 231- the 3rd；
The container tubes of 24- the 4th；The valves of 241- the 4th；
3- sources of the gas；31- malleation sources of the gas；32- negative pressure sources of the gas；
The valves of 4- first；41- the first malleation valves；The negative pressure valves of 42- first；
5- stable-pressure devices；51- positive valves；52- negative pressure valves；
The air inlet pipe of 6- first；The air inlet pipe of 7- second；
8- gas pressure control devices；9- air-flows are opened and closed timer.
Embodiment
Technical scheme is clearly and completely described below in conjunction with accompanying drawing, it is clear that described implementation
Example is part of the embodiment of the present invention, rather than whole embodiments.Based on the embodiment in the present invention, ordinary skill
The every other embodiment that personnel are obtained under the premise of creative work is not made, belongs to the scope of protection of the invention.
In the description of the invention, it is necessary to explanation, term " " center ", " on ", " under ", "left", "right", " vertical ",
The orientation or position relationship of the instruction such as " level ", " interior ", " outer " be based on orientation shown in the drawings or position relationship, merely to
Be easy to the description present invention and simplify description, rather than instruction or imply signified device or element must have specific orientation,
With specific azimuth configuration and operation, therefore it is not considered as limiting the invention.In addition, term " first ", " second ",
" the 3rd " is only used for describing purpose, and it is not intended that instruction or hint relative importance.
In the description of the invention, it is necessary to illustrate, unless otherwise clearly defined and limited, term " installation ", " phase
Even ", " connection " should be interpreted broadly, for example, it may be being fixedly connected or being detachably connected, or be integrally connected；Can
To be mechanical connection or electrical connection；Can be joined directly together, can also be indirectly connected by intermediary, Ke Yishi
The connection of two element internals.For the ordinary skill in the art, with concrete condition above-mentioned term can be understood at this
Concrete meaning in invention.
Embodiment
Prepared referring to a kind of obstructive sleep respiratory disorder disease animal model shown in Fig. 1-Fig. 3, is present embodiments provided
System；Fig. 1-Fig. 3 is the first structure for the obstructive sleep respiratory disorder disease animal model preparation system that the present embodiment provides
Schematic diagram is to the 3rd structural representation.
Referring to the obstructive sleep respiratory disorder disease animal model preparation system that shown in Fig. 1-Fig. 3, the present embodiment provides
(hereinafter referred to as model preparation system), including head-shield 1 and simulation case 2.It for example can be pipeline system to simulate case 2
System, the container that can be closed etc..The material of case 2 is simulated such as can be plastics, glass, metal.
The first end of simulation case 2 is connected with the inside of head-shield 1, and corresponding second end of simulation case 2 is used
In connection source of the gas 3；The first valve 4 is provided between simulation case 2 and source of the gas 3；First valve 4 is used to control simulation container
Gas path on-off between device 2 and source of the gas 3.Source of the gas 3 for example can be positive pressure source, negative pressure source or atmospheric pressure.Source of the gas 3 for example can be with
Air, oxygen, nitrogen etc. are provided.Wherein, the pressure value for the source of the gas 3 that positive pressure source provides is more than atmospheric value, what negative pressure source provided
The pressure value of source of the gas 3 is less than atmospheric value.
The open at one end 12 of head-shield 1, and head-shield 1 is used to be enclosed on purpose animal outside；The opening 12 of head-shield 1 can be with purpose
The neck seal connection of animal.Wherein, purpose animal is such as can be small white mouse, rabbit.Preferably, head-shield 1 being capable of overcoat
On the head of animal, it is enclosed on outside the opening 12 of head-shield 1 on the neck of animal, so that head-shield of the head of purpose animal positioned at closing
Inside 1.
What is overcome during animal eupnea is atmospheric pressure, simulates and is connected with stable-pressure device 5 on case 2, dynamic to simulate
Positive/negative-pressure needed for the atmospheric pressure and Studies On Blocking sleep disordered breathing disease of thing eupnea；Stable-pressure device 5 is default
There is pressure threshold, for controlling the gas path on-off inside and outside simulation case 2.Pressure threshold can be malleation value, negative pressure value or
Person's atmospheric value.It can select to prevent air blow back, holding atmospheric pressure from negative pressure replacing by stable-pressure device 5, keep malleation to lead to
Gas.
The preparation system of obstructive sleep respiratory disorder disease animal model described in the present embodiment, including head-shield 1 and simulation
Case 2, by connecting stable-pressure device 5 on simulation case 2, to ensure that it is pre- to simulate the air pressure in case 2
If malleation, the pressure threshold of negative pressure or atmospheric pressure；By will be enclosed on outside head-shield 1 on the head of purpose animal, so that animal exists
Can both keep natural atmosphere to press autonomous respiration in model preparation system, can isolate again in breathing with external environment so that
Pressure, the oxygen content of its air sucked are controllable, can also make to keep subnormal ambient in model preparation system；Make its effective mould
Intended sleep-respiratory road interruption obstruction, the scene such as intake negative-pressure, for improve the understanding of obstructive sleep respiratory disorder disease with
Treatment provides experiment basis.
Alternatively, oronasal mask 11 is fixedly installed on head-shield 1, the hardness of oronasal mask 11 is better than the hardness of head-shield 1；It is preferred that
Ground, oronasal mask 11 use hard material, and head-shield 1 uses soft material；Simulate case 2 and pass through oronasal mask 11 and head-shield 1
Inside connection.Preferably, oronasal mask 11 is corresponding with the mouth and nose of purpose animal.By oronasal mask 11 to avoid purpose animal from exhaling
During suction, head-shield 1 is fitted on mouth and nose and hinders breathing.
Further, head-shield 1 uses medical grade rubber film or medical plastic film；Oronasal mask 11 uses medical grade rubber or doctor
Use plastics.Preferably, the opening 12 of head-shield 1 is flexible, and there is elastic band at the edge of the opening 12 of such as head-shield 1, so that head-shield 1
Opening 12 can be effectively tightly connected with purpose animal.
In the alternative of the present embodiment, obstructive sleep respiratory disorder disease animal model preparation system also includes gas
Pressure control device 8 and air-flow opening and closing timer 9；First valve 4, air-flow opening and closing timer 9 control with gas pressure fill respectively
Put 8 electrical connections.
Gas pressure control device 8 is used for the keying for controlling the first valve 4；Air-flow opening and closing timer 9 is used to monitor first
The keying duration of valve 4.Timer 9 and gas pressure control device 8 are opened and closed by air-flow simulation container filled with improving source of the gas 3
The accuracy of the duration of injection gas in 2 is put, and then is easy to the volume of injection gas, simulation in calculating simulation case 2 to hold
Oxygen content, pressure and other parameters in device device 2.
Further, shown in Figure 2, the first valve 4 includes the first malleation valve 41 and the first negative pressure valve 42；First
Malleation valve 41, the first negative pressure valve 42 electrically connect with gas pressure control device 8 respectively；
First malleation valve 41 is used to connect malleation source of the gas 31, so that pressure threshold is malleation value, that is, passes through stable-pressure device 5
Simulation case 2 is set to remain malleation value；First negative pressure valve 42 is used to connect negative pressure source of the gas 32, so that pressure threshold is negative
Pressure value, i.e., simulation case 2 is set to remain negative pressure value by stable-pressure device 5.
Gas pressure control device 8 is used for the keying for controlling the first malleation valve 41, the first negative pressure valve 42 respectively；Air-flow
Opening and closing timer 9 is used to monitor the first malleation valve 41, the keying duration of the first negative pressure valve 42 respectively.Pass through gas pressure control
Device 8 and air-flow processed are opened and closed timer 9, can control malleation and negative pressure alt time and stress level in simulation case 2,
So as to empirically require to select different degrees of obstructive sleep respiratory disorder；Anoxic can only be manufactured by solving existing apparatus
Model, it is impossible to the problem of accurate adjustment respiratory pressure and degree of oxygen deficiency, so as to simulate the mankind in obstructive sleep respiratory disorder
Pathophysiological process in property disease.
Preferably, the obstructive sleep respiratory disorder disease animal model preparation system also includes the He of the first air inlet pipe 6
Second air inlet pipe 7；Simulate the second end first end with the first air inlet pipe 6, the first of the second air inlet pipe 7 respectively of case 2
End connection.
Corresponding second end of first air inlet pipe 6 is connected with the first malleation valve 41, and corresponding the second of the second air inlet pipe 7
End is connected with the first negative pressure valve 42.
First air inlet pipe 6 is identical with the length of the second air inlet pipe 7；So that the first malleation valve 41 and the first negative pressure valve 42
It is identical with the distance for simulating case 2, and then improve the accuracy of experiment.Wherein, the first air inlet pipe 6 and the second air inlet pipe 7
Material such as can be plastics, glass, metal.
Preferably, malleation source of the gas 31 is constant pressure source or becomes potential source, if malleation source of the gas 31 is oxygen cylinder, air pump；Negative pressure gas
Source 32 is constant pressure source or becomes potential source, if negative pressure source of the gas 32 is vavuum pump.
Referring to shown in Fig. 2, Fig. 3, in the alternative of the present embodiment, simulation case 2 includes the He of the first container tube 21
Second container pipe 22, the first end of the first container tube 21 connect with the inside of head-shield 1, corresponding second end of the first container tube 21
For connecting source of the gas 3；First valve 4 is arranged between the first container tube 21 and source of the gas 3.
Second container pipe 22 connects with the first container tube 21；Preferably, the first end of second container pipe 22 and the first container
The first end connection of pipe 21, corresponding second end of second container pipe 22 connects with the second end of the first container tube 21；Namely the
Two container tubes 22 are connected in parallel with the first container tube 21.
Stable-pressure device 5 is arranged on second container pipe 22；Pressure threshold is malleation value, negative pressure value or atmospheric value.Surely
Pressure device 5 for example can be positive valve, negative pressure valve, opening so that kept in simulation case 2 malleation value, negative pressure value or
Atmospheric value.By the container tube 21 of second container pipe 22 and first, so that the airflow of simulation case 2 is more smooth,
And then make the pressure in simulation case 2 relatively uniform.
It should be noted that positive valve is positive check valve；When pressure in simulation case 2 is more than pressure threshold,
The valve of positive valve is opened, outwards the gas in release simulation case 2；Pressure in simulation case 2 is less than pressure
During threshold value, the valve of positive valve is closed.
Negative pressure valve is reverse check valve；When pressure in simulation case 2 is less than pressure threshold, the valve of negative pressure valve is beaten
Open, inject gas into simulation case 2；When pressure in simulation case 2 is more than pressure threshold, the valve of negative pressure valve
Close.
Further, simulation case 2 also includes the 3rd container tube 23；The first end of 3rd container tube 23 is held with first
The first end connection of device pipe 21, corresponding second end of the 3rd container tube 23 connects with the second end of the first container tube 21；Namely
3rd container tube 23 is connected in parallel with the first container tube 21.Preferably, the first container tube 21, second container pipe 22, the 3rd container
Pipe 23 is connected in parallel.
Stable-pressure device 5 includes positive valve 51 and negative pressure valve 52.
Positive valve 51 is arranged on second container pipe 22；The second valve 221, the second valve are installed with second container pipe 22
221 are separately positioned on the both sides of positive valve 51.
Negative pressure valve 52 is arranged in the 3rd container tube 23；The 3rd valve 231, the 3rd valve are installed with 3rd container tube 23
231 are separately positioned on the both sides of negative pressure valve 52.By be installed with second container pipe 22 positive valve 51, in the 3rd container tube 23 it is fixed
There is negative pressure valve 52, so that the positive/negative pressure in simulation case 2 is alternately more convenient.The domestic demand of case 2 is simulated to keep just
During pressure value, the second valve 221 is opened so that positive valve 51 and the pathway patency in simulation case 2, close the 3rd valve 231
So that negative pressure valve 52 disconnects with the path in simulation case 2；When simulating case 2 domestic demand and keeping negative pressure value, the is closed
Two valves 221 are so that positive valve 51 disconnects with the path in simulation case 2, and the 3rd valve 231 of opening is so that negative pressure valve 52
With the pathway patency in simulation case 2.
Further, simulation case 2 also includes the 4th container tube 24.
The first end of 4th container tube 24 connects with the first container tube 21, and corresponding second end of the 4th container tube 24 opens
Mouthful；The 4th valve 241 is installed with 4th container tube 24.So that the holding atmospheric pressure in simulation case 2 is more convenient.Mould
When intending the domestic demand of case 2 holding atmospheric value, the 4th valve 241 is opened so that air and the path in simulation case 2
It is unimpeded, the second valve 221, the 3rd valve 231 are closed so that positive valve 51, negative pressure valve 52 and the path in simulation case 2
Disconnect.
Finally it should be noted that：Various embodiments above is merely illustrative of the technical solution of the present invention, rather than its limitations；To the greatest extent
The present invention is described in detail with reference to foregoing embodiments for pipe, it will be understood by those within the art that：Its according to
The technical scheme described in foregoing embodiments can so be modified, either which part or all technical characteristic are entered
Row equivalent substitution；And these modifications or replacement, the essence of appropriate technical solution is departed from various embodiments of the present invention technology
The scope of scheme.
Claims (9)
1. a kind of obstructive sleep respiratory disorder disease animal model preparation system, it is characterised in that hold including head-shield and simulation
Device device；
The first end of the simulation case connects with the inside of the head-shield, and corresponding the second of the simulation case
Hold for connecting source of the gas；The first valve is provided between the simulation case and the source of the gas；
The open at one end of the head-shield, and the head-shield is used to be enclosed on purpose animal outside；The opening of the head-shield can be with institute
State the neck seal connection of purpose animal；
Stable-pressure device is connected with the simulation case；The stable-pressure device is preset with pressure threshold, described for controlling
Simulate the gas path on-off inside and outside case；
Also include gas pressure control device and air-flow opening and closing timer；First valve, air-flow opening and closing timer point
Do not electrically connected with the gas pressure control device；
The gas pressure control device is used for the keying for controlling first valve；The air-flow opening and closing timer is used to monitor
The keying duration of first valve.
2. obstructive sleep respiratory disorder disease animal model preparation system according to claim 1, it is characterised in that institute
State and oronasal mask is fixedly installed on head-shield；The simulation case is connected by the oronasal mask with the inside of the head-shield；
The oronasal mask uses hard material, and the head-shield uses soft material.
3. obstructive sleep respiratory disorder disease animal model preparation system according to claim 2, it is characterised in that institute
State head-shield and use medical grade rubber film or medical plastic film；The oronasal mask uses medical grade rubber or medical plastic.
4. obstructive sleep respiratory disorder disease animal model preparation system according to claim 1, it is characterised in that institute
Stating the first valve includes the first malleation valve and the first negative pressure valve；The first malleation valve, first negative pressure valve point
Do not electrically connected with the gas pressure control device；
The first malleation valve is used to connect malleation source of the gas, and first negative pressure valve is used to connect negative pressure source of the gas；
The gas pressure control device is used for the keying for controlling the first malleation valve, first negative pressure valve respectively；
The air-flow opening and closing timer is used to monitor the first malleation valve, the keying duration of first negative pressure valve respectively.
5. obstructive sleep respiratory disorder disease animal model preparation system according to claim 4, it is characterised in that also
Including the first air inlet pipe and the second air inlet pipe；It is described simulation case the second end respectively with first air inlet pipe first
End, the first end connection of second air inlet pipe；
Corresponding second end of first air inlet pipe is connected with the first malleation valve, second air inlet pipe it is corresponding
Second end is connected with first negative pressure valve；
First air inlet pipe is identical with the length of second air inlet pipe.
6. obstructive sleep respiratory disorder disease animal model preparation system according to claim 4, it is characterised in that institute
Malleation source of the gas is stated as constant pressure source or becomes potential source；The negative pressure source of the gas is constant pressure source or becomes potential source.
7. the obstructive sleep respiratory disorder disease animal model preparation system according to claim any one of 1-6, it is special
Sign is that the simulation case includes the first container tube and second container pipe, the first end of first container tube and institute
The inside connection of head-shield is stated, corresponding second end of first container tube is used to connect the source of the gas；
The first end of the second container pipe connects with the first end of first container tube, the second container pipe it is corresponding
Second end connects with the second end of first container tube；
The stable-pressure device is arranged on the second container pipe；The pressure threshold is malleation value, negative pressure value or atmospheric pressure
Value.
8. obstructive sleep respiratory disorder disease animal model preparation system according to claim 7, it is characterised in that institute
Stating simulation case also includes the 3rd container tube；The first end of 3rd container tube and the first end of first container tube
Connection, corresponding second end of the 3rd container tube connects with the second end of first container tube；
The stable-pressure device includes positive valve and negative pressure valve；
The positive valve is arranged on the second container pipe；It is installed with the second valve on the second container pipe, described second
Valve is separately positioned on the positive valve both sides；
The negative pressure valve is arranged in the 3rd container tube；It is installed with the 3rd valve in 3rd container tube, the described 3rd
Valve is separately positioned on the negative pressure valve both sides.
9. obstructive sleep respiratory disorder disease animal model preparation system according to claim 8, it is characterised in that institute
Stating simulation case also includes the 4th container tube；
The first end of 4th container tube connects with first container tube, and corresponding second end of the 4th container tube opens
Mouthful；The 4th valve is installed with 4th container tube.
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| CN201610302477.4A CN105726156B (en) | 2016-05-06 | 2016-05-06 | Obstructive sleep respiratory disorder disease animal model preparation system |
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| CN201610302477.4A CN105726156B (en) | 2016-05-06 | 2016-05-06 | Obstructive sleep respiratory disorder disease animal model preparation system |
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Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201551414U (en) * | 2009-11-16 | 2010-08-18 | 中国人民解放军第三军医大学第一附属医院 | Rat continuous inhalation anesthesia device |
| CN202554160U (en) * | 2012-04-19 | 2012-11-28 | 四川科伦药业股份有限公司 | Self-control type animal experiment hypoxia chamber |
| CN204016480U (en) * | 2014-07-10 | 2014-12-17 | 浙江大学医学院附属邵逸夫医院 | A kind of animal hypoxia experimental box |
| CN104799967B (en) * | 2015-04-29 | 2017-03-15 | 山东大学 | Integral type mammal anoxic experimental simulation device and method |
| CN105662639A (en) * | 2016-01-28 | 2016-06-15 | 兰州大学第一医院 | Fully-automatic oxygen control animal tank |
| CN205659019U (en) * | 2016-05-06 | 2016-10-26 | 于兆衍 | Block nature sleep and breathe obstacle disease animal models preparation system |
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