CN105724398A - Antifungal composition and application thereof - Google Patents
Antifungal composition and application thereof Download PDFInfo
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- CN105724398A CN105724398A CN201410764050.7A CN201410764050A CN105724398A CN 105724398 A CN105724398 A CN 105724398A CN 201410764050 A CN201410764050 A CN 201410764050A CN 105724398 A CN105724398 A CN 105724398A
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Abstract
The invention belongs to the field of an agricultural fungicide, and in particular to an antifungal composition. The composition comprises two active components of A and B, wherein the weight ratio of the component A and the component B is in a range of 1: 100 to 100:1; the component A is selected from a compound represented by the following formula shown in the description; and the component B is one or several selected from the group consisting of amides fungicides. The antifungal composition is particularly suitable for controlling multiple kinds of plant pathogenic fungi diseases such as plant downy mildew, peronophythoraceae, late blight, phytophthora disease, black shank or damping-off.
Description
Technical field
The invention belongs to disinfectant use in agriculture field, specifically a kind of Fungicidal composition.
Background technology
Patent WO2011116671 " a kind of substituted diphenylamine aminated compounds and preparation and application thereof " reports the compound shown in below formula I multiple fungal disease is had good activity.
Wherein, R1=H, R2=Cl, R3=NO2、R4=R8=Cl, R5=R7=H, R6=NO2Compound A1 (in WO2011116671 compound 43) multiple diseases is had good activity.
The antibacterial of amide-type such as metalaxyl, dimethomorph, flumorph, fluopicolide etc. are the widely used obligate antibacterial of class that Oomycete fungal disease has prominent prevention effect in agricultural production.Because this series bactericidal agent has good interior absorption, and action site is single, and part kind is after such as metalaxyl, M 9834 etc. are reused for a long time, and pathogenic bacteria Drug resistance is extremely serious, and field efficacy is remarkably decreased.
In the practice of antibacterial application, the antibacterial mixing with the different mechanism of action or different model of action is often used by people consciously, improves the protection effect of medicament, and also to reach the purpose of saving of work and time.
Summary of the invention
It is an object of the invention to provide a kind of Fungicidal composition and application thereof, to delay the drug-fast generation of pathogen, extend the service life of medicament.
For achieving the above object, the present invention adopts the technical scheme to be:
A kind of Fungicidal composition, containing two kinds of active components of A, B, the weight ratio between component A and component B two component is 1:100～100:1；
Component A is selected from the compound shown in formula I:
In formula:
R1Selected from hydrogen, C1-C12Alkyl, C3-C12Cycloalkyl, halo C1-C12Alkyl, C1-C12Alkyl-carbonyl, halo C1-C12Alkyl-carbonyl, C1-C12Alkoxy carbonyl, C1-C12Alkyl amino-carbonyl, C1-C12Alkylthio group, halo C1-C12Alkylthio group, C1-C12Alkyl sulphonyl, C1-C12Alkoxy C1-C12Alkyl, C1-C12Alkoxy C1-C12Alkyl-carbonyl, C1-C12Alkoxy carbonyl C1-C12Alkyl, C1-C12Alkyl amino sulfenyl, C2-C12Dialkyl amido sulfenyl or CO-X-CO2R9, wherein X is selected from (CHR9)n、CR9=CR10Or C6H4, n=1-6；
R2Selected from halogen, halo C1-C12Alkyl, C1-C12Alkoxyl, halo C1-C12Alkoxyl, C1-C12Alkyl amino, halo C1-C12Alkyl amino, C1-C12Alkylthio group, halo C1-C12Alkylthio group, C1-C12Alkyl sulphonyl, C3-C12Cycloalkyl, C2-C12Dialkyl amido, C3-C12Alkene oxygen base, halo C3-C12Alkene oxygen base, C3-C12Alkynyloxy group, halo C3-C12Alkynyloxy group, C1-C12Alkyl-carbonyl oxygen base, C1-C12Alkyl-carbonyl-amino, C1-C12Alkyl sulphonyl oxygen base, C1-C12Alkoxy C1-C12Alkoxyl, C1-C12Alkoxy carbonyl C1-C12Alkoxyl, unsubstituted or by 1-5 R11Following radicals aryloxy group, virtue amino, arylmethyl oxygen base, arylmethyl amino, heteroaryl oxygen base or the heteroaryl amino replaced, and by R11When the number replaced is more than 1, R11May be the same or different；
R3Selected from hydrogen, halogen, nitro, cyano group, C (=O) NR9R10, C (=S) NR9R10、C1-C12Alkyl amino-carbonyl, C1-C12Alkoxy carbonyl, halo C1-C12Alkyl or C1-C12Alkyl sulphonyl；
R4、R8What may be the same or different is selected from hydrogen, halogen, cyano group, nitro, C (=O) NR9R10、C1-C12Alkyl, halo C1-C12Alkyl, C1-C12Alkoxyl, halo C1-C12Alkoxyl, C2-C12Thiazolinyl, C2-C12Alkynyl, C1-C12Alkyl sulphonyl, C1-C12Alkyl-carbonyl, C1-C12Alkoxy carbonyl, C1-C12Alkoxy C1-C12Alkyl, C1-C12Alkoxy carbonyl C1-C12Alkyl, unsubstituted or by 1-5 R11Aryl, arylmethyl, aryloxy group, virtue amino, aryl carbonyl, arylmethyl carbonyl, aryloxycarbonyl, aromatic yl aminocarbonyl or the heteroaryl oxygen base replaced, and by R11When the number replaced is more than 1, R11May be the same or different；
R5、R7What may be the same or different is selected from hydrogen, halogen, cyano group, nitro, C (=O) NR9R10、C1-C12Alkyl, halo C1-C12Alkyl, C1-C12Alkoxyl, halo C1-C12Alkoxyl, C1-C12Alkyl amino, halo C1-C12Alkyl amino, C1-C12Alkylthio group, halo C1-C12Alkylthio group, C2-C12Thiazolinyl, C2-C12Alkynyl, C1-C12Alkyl sulphonyl, C1-C12Alkyl-carbonyl, C1-C12Alkoxy carbonyl, C1-C12Alkoxy C1-C12Alkyl, C1-C12Alkoxy carbonyl C1-C12Alkyl, C1-C12Alkyl-carbonyl oxygen base, C1-C12Alkoxy-carbonyl oxy, C1-C12Alkyl amino carbonyl oxy, C1-C12Alkyl sulphonyl oxygen base, C1-C12Alkoxy C1-C12Alkoxyl, halo C1-C12Halogenated alkoxy C1-C12Alkoxyl, C1-C12Alkoxy carbonyl C1-C12Alkoxyl, unsubstituted or by 1-5 R11Aryl, arylmethyl, aryloxy group, virtue amino, aryl carbonyl, arylmethyl carbonyl, aryloxycarbonyl, aromatic yl aminocarbonyl or the heteroaryl oxygen base replaced, and by R1When the number replaced is more than 1, R11May be the same or different；
R6Selected from hydrogen, halogen, cyano group, nitro, carboxyl, C (=O) NR9R10、C1-C12Alkyl, halo C1-C12Alkyl, C1-C12Alkoxyl, halo C1-C12Alkoxyl, C2-C12Thiazolinyl, C2-C12Alkynyl, C1-C12Alkyl sulphonyl, C1-C12Alkyl-carbonyl, C1-C12Alkoxy carbonyl, C1-C12Alkoxy C1-C12Alkyl, C1-C12Alkoxy carbonyl C1-C12Alkyl, C1-C12Alkoxy C1-C12Alkoxyl, halo C1-C12Halogenated alkoxy C1-C12Alkoxyl, unsubstituted or by 1-5 R11Aryl, arylmethyl, aryloxy group, virtue amino, aryl carbonyl, arylmethyl carbonyl, aryloxycarbonyl, aromatic yl aminocarbonyl or the heteroaryl oxygen base replaced, and by R11When the number replaced is more than 1, R11May be the same or different；
But, R4、R5、R6、R7、R8It is not simultaneously selected from H；
R9、R10What may be the same or different is selected from hydrogen or C1-C6Alkyl；
R11Selected from halogen, nitro, cyano group, C1-C6Alkyl, halo C1-C6Alkyl, C1-C6Alkoxyl, halo C1-C6Alkoxyl, C1-C6Alkylthio group, C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, C2-C6Thiazolinyl, halo C2-C6Thiazolinyl, C3-C6Alkene oxygen base, halo C3-C6Alkene oxygen base, C2-C6Alkynyl, halo C2-C6Alkynyl, C3-C6Alkynyloxy group, halo C3-C6Alkynyloxy group, halo C1-C6Alkylthio group, halo C1-C6Alkyl-carbonyl, C1-C6Alkyl amino, halo C1-C6Alkyl amino, C2-C8Dialkyl amido, C1-C6Alkyl-carbonyl-amino, halo C1-C6Alkyl-carbonyl-amino, C1-C6Alkyl amino-carbonyl or halo C1-C6Alkyl amino-carbonyl；
Or the salt of compound of Formula I.
One or more in the antibacterial of amide-type of component B.
The present invention more preferably technical scheme is: in above-mentioned Fungicidal composition, and active component A is R in formula I1=H, R2=Cl, R3=NO2、R4=R8=Cl, R5=R7=H, R6=NO2Compound A1.
The antibacterial of component B amide-type is selected from flumorph (flumorph) B1, dimethomorph (dimethomorph) B2, fluopicolide (fluopicolide) B3, mandipropamid (mandipropamid) B4, zoxamide (zoxamide) B5, iprovalicarb (iprovalicarb) B6, cymoxanil (cymoxanil) B7, metalaxyl (metalaxyl-M) B8 or M 9834 (benalaxyl-M) B9.
The present invention it is preferred that technical scheme be: in described Fungicidal composition, active component A be selected from compound A1；Active component B is selected from flumorph B1, dimethomorph B2, fluopicolide B3, mandipropamid B4 or zoxamide B5；Weight ratio between two kinds of active components of described A, B is 1:50～50:1.
The present invention further preferred technical scheme is: in described Fungicidal composition, active component A is selected from compound A1；Active component B is selected from flumorph B1, dimethomorph B2 or fluopicolide B3；Weight ratio between two kinds of active components of described A, B is 10:1～1:40.
The application of a kind of Fungicidal composition, described Fungicidal composition is for preparing the medicine of preventing and treating plant pathogenic fungi disease.
The described true compositions effective ingredient as medicine that sterilizes, effective content is 0.1～95wt%.
Described Fungicidal composition is configured to dispersible agent, aqueous emulsion, suspending agent, water dispersible granules or wettable powder.
It was unexpectedly observed that active component A uses with active component B combination in the technical scheme that inventor states on the implementation, when different mixed ratio, the prevention effect of compositions significantly improves, and synergistic function is fairly obvious.
Downy mildew in the multiple diseases that Oomycete fungal is caused by Fungicidal composition of the present invention especially vegetable category (Fructus Cucumidis sativi, Fructus Melo, Citrullus vulgaris, Fructus Lycopersici esculenti etc.), fruit tree (Fructus Litchi), climbing plant (Fructus Vitis viniferae, Fructus actinidiae chinensis), cereal crops (Oryza sativa L., Rhizoma Solani tuber osi) and industrial crops (Nicotiana tabacum L., Flos lupuli (Flos Humuli Lupuli)), peronospora tabacina, late blight, epidemic disease, balck shank, damping off etc. have good prevention effect.
Fungicidal composition of the present invention is particularly suitable for preventing and treating following plants disease: cucumber downy mildew, muskmelon downy mildew, downy mildew of garpe, hop downy mildew, peronophythora litchi, tomato late blight, the late blight of potato, capsicum epidemic disease, Citrullus vulgaris epidemic disease, Fructus actinidiae chinensis phytophthora root rot, Fructus Cucumidis sativi damping off, Fructus Solani melongenae damping off, Fructus Capsici damping off, Oryza sativa L. damping off, black shank etc..
Occurrence degree according to corps diseases, the present composition working concentration in proportion of crop planting region is 5～1500mg/L (active constituent content, lower same), it is preferable that 50～1000mg/L.
Technical scheme also includes said composition as the purposes of antifungal and the using method preventing and treating above-mentioned disease, namely component A and at least one component B prepares in advance according to appropriate proportioning provided by the invention or is using extemporaneous preparation or individually using successively, all present significant protection effect or substantially expansion disease prevent and treat kind.
The present composition can be made into the pharmaceutical preparation containing 0.1～95% (weight) active component, it is preferable that containing the pharmaceutical preparation of 5～80% (weight) active component.
The Fungicidal composition of the present invention can be processed into the aqueous or oily suspensions, the multiple dosage form such as powder, particulate matter that use after directly using or being watered.Above-mentioned various preparation all can be prepared in a known manner.Such as active component is mixed with solvent and/or carrier and prepares, if desired, auxiliary agent and the surfactants such as emulsifying agent, dispersant, wetting agent can be added.These preparations include liquid preparation and solid preparation, such as common formulations of pesticide such as dispersible agent (DC), aqueous emulsion (EW), suspending agent (SC), water dispersible granules (WG), wettable powders (WP).
Suitable solvent or auxiliary agent are mainly water, benzene, dimethylbenzene, toluene, alkylbenzene, aliphatic hydrocarbon, alcohols, esters, ketone, also have vegetable oil and the molten fiber of methyl etc..Meanwhile, the mixture of different liquids is also applicable.
Suitable surfactant is lignin sulfonic acid, LOMAR PWA EINECS 246-676-2, phenolsulfonic acid, the alkali metal salt of dibutyl naphthalenesulfonic acid, alkali salt and ammonium salt, alkylaryl sulfonates, alkyl sulfate, alkylsulfonate, aliphatic alcohol sulfate etc..
Suitable wetting agent is sodium laurylsulfate, sodium lauryl sulphate, dodecyl sodium sulfate, sodium alkyl benzene sulfonate, Negel, sorbitan fatty acid ester polyoxyethylene ether etc..
The example of preparing of certain formulations is listed below, and wherein said active component is the diphenylamine compound A1 in the Fungicidal composition of the present invention with the suitable proportion between acid amide fungicides B, A, two kinds of active components of B as previously mentioned.
Suspending agent (SC)
In the ball mill of stirring, add the 20% compositions active component pulverized, 5% part of naphthalenesulfonic acid-formaldehyde condensate, 0.08% xanthan gum, 0.1% White Carbon black, 4.0% agriculture breast 0201B, 4% ethylene glycol, a little defoamer, finally complements to 100% with water, prepares active component suspending agent in small, broken bits.Dilute with water obtains suspension, for stem and leaf spraying or soil pouring.
Water dispersible granules (WG)
By 50% compositions active component of grinding in small, broken bits, 12% Oleum Ricini ethylene oxide adduct, 2% polyvinylpyrrolidone, alkane 10% base phenol polyethenoxy base ether formaldehyde condensation products sulfate, 2.8% phenolic resin, 23.2% Gypsum Fibrosum mixing, by extruder, spray tower, fluid bed, makes water dispersible or water-soluble granular formulation.Dilute with water obtains dispersion or solution, for stem and leaf spraying or soil pouring.
Wettable powder (WP)
40% compositions active component is ground and added 1.8% sodium laurylsulfate, 10% White Carbon black, 8% sodium lignin sulfonate, 6% pair of (alkyl) naphthalenesulfonate formaldehyde condensation compound, 34.2% precipitated calcium carbonate in rotor-stator grinder, make powder preparation.Dilute with water obtains dispersion or solution, for stem and leaf spraying or soil pouring.
It addition, polytype oil, wetting agent, adjuvant, herbicide, antifungal, other pesticide can add in the present composition.These compositions generally mix with the weight ratio of 1:30～30:1 with the present composition.
Advantage for present invention: the present invention using containing the substituted diphenylamine aminated compounds shown in formula I as active component in the lump by lot of experiments and research, determine the suitable mixed ratio of Fungicidal composition being active component with the antibacterial of the substituted diphenylamine aminated compounds shown in formula I Yu amide-type, obtain Fungicidal composition, play its potentiation, to improve the prevention effect to corps diseases, and reduce compositions using dosage, the more important thing is and the antimicrobial combination with the different mechanism of action is used, the drug-fast generation of pathogen can be delayed, extend the service life of medicament.
Detailed description of the invention
The synergistic function of harmful fungoid can be described further by the present composition by the following example, but the present invention is only limitted to absolutely not this.Wherein said active component is the compound A1 and amide-type part antibacterial B of one of the diphenylamine compound in the Fungicidal composition of the present invention.
Wherein, compound A1 can obtain according to the record in patent WO2011116671 " a kind of substituted diphenylamine aminated compounds and preparation and application thereof ".Component B is commercially available or prepares according to known methods.
Method of testing and evaluation methodology are as follows:
Active sample to be measured respectively compound A1, flumorph B1, dimethomorph B2, fluopicolide B3, mandipropamid B4, zoxamide B5, metalaxyl B8；It is specially compound A1 and flumorph B1, compound A1 and dimethomorph B2, compound A1 and fluopicolide B3, compound A1 and mandipropamid B4, compound A1 and zoxamide B5, compound A1 and metalaxyl B8.
Concrete mode:
Active ingredient matter sample or composition sample are prepared into, by the method that example enumerates of preparing of above-mentioned preparation, the wettable powder that effective content is 40%；Weigh appropriate formulation samples, after adding water, be configured to desired concn liquid to be measured.
On crops sprayer, above-mentioned liquid to be measured is sprayed on disease host plant, after 24 hours, carry out disease inoculation.According to disease feature, it would be desirable to be placed in climatic chamber after the disease plant inoculating that temperature control moisturizing is cultivated and cultivate, after disease completes to infect, move into hot-house culture.After compareing fully morbidity, measure pathogen and infect Crop leaf area percent, use Abbot formula to calculate, namely obtain observing effect (W):
W=(1-α/β) × 100
In formula:
α: process the fungal infection percent of crop；
β: the fungal infection percent of untreated (blank) crop；
Effect process for " 0 " expression the level that infects and the untreated control crop of crop to infect level identical；Effect processes crop for " 100 " expression and is not infected.
The expection effect (calculating effect) of compositions uses Colby formula (see R.S.Colby, weeds (Weeds), 1967,15,20-22) to determine, and compares with observing effect.
E=X+Y XY/100
In formula:
E: working concentration is the expection effect (the calculating effect in following table) during the compositions of the active component A of a and b and B, represents with the % of untreated control；
X: working concentration is the effect of active component A during a, represents with the % of untreated control；
Y: working concentration is the effect of active component B during b, represents with the % of untreated control.
When observing effect value more than, when calculating effect value, representing that compositions has potentiation；When observing effect value equal to when calculating effect value, expression compositions is adduction；When observing effect value less than when calculating effect value, expression compositions is antagonism.
Implementation of an application example 1 prevents and treats cucumber downy mildew test
Potted plant two leaf phase cucumber seedling liquid to be measured (concentration the is as described below) sprayings that kind is " the close thorn in Xintai City " are processed, after 24 hours, inoculates test plants with the sporangia suspension of cucumber downy mildew.Test plants is placed in the climatic chamber that temperature is 22 ± 2 DEG C and relative humidity is 90 ± 5% and cultivates, after 24 hours, move into greenhouse normal management.After 5 days, measure the degree of infection process on blade.The activity data result of each independent active component and present composition preventing and treating cucumber downy mildew is in Table 1 and table 2.
Result shows, the observation effect value of compositions is all higher than calculating effect value.Illustrate that compositions shows as potentiation in test ratio range.
The activity of the independent active component of table 1
The activity of table 2 present composition
Implementation of an application example 2 prevents and treats downy mildew of garpe test
Potted plant five leaf phase cutting seedling liquid to be measured (concentration the is as described below) sprayings of Fructus Vitis viniferae that kind is " the seedless Cold boiled chicken heart " are processed, after 24 hours, inoculates test plants with the sporangia suspension of downy mildew of garpe.Test plants is placed in the climatic chamber that temperature is 23 ± 2 DEG C and relative humidity is 90 ± 5% and cultivates, after 24 hours, move into greenhouse normal management.After 7 days, measure the degree of infection process on blade.Each independent active component and the present composition prevent and treat the activity data result of downy mildew of garpe in Table 3 and table 4.
Result shows, the observation effect value of compositions is all higher than calculating effect value.Illustrate that compositions shows as potentiation in test ratio range.
The activity of the independent active component of table 3
The activity of table 4 present composition
Implementation of an application example 3 prevents and treats tomato late blight test
This test adopts spore germination method, namely presses design concentration, takes high concentration liquid to be measured and mix with sporangia suspension, obtain active sample to be measured--Sporangium mixed liquor, and add in 96 well culture plates, it is subsequently placed in incubator and cultivates (22 DEG C ± 1 DEG C), microscopy after 4 hours.The Sporangium Germination suppression rate of compositions and each independent active component is obtained according to following formula.Compositions interaction analysis adopts foregoing Colby formula.The activity data result of each independent active component and present composition preventing and treating tomato late blight is in Table 5 and table 6.
Result shows, the observation effect value of compositions is all higher than calculating effect value.Illustrate that compositions shows as potentiation in test ratio range.
The activity of the independent active component of table 5
The activity of table 6 present composition
Implementation of an application example 4 prevents and treats capsicum epidemic disease test
This test adopts spore germination method, namely presses design concentration, takes high concentration liquid to be measured and mix with sporangia suspension, obtain active sample to be measured--Sporangium mixed liquor, and add in 96 well culture plates, it is subsequently placed in incubator and cultivates (22 DEG C ± 1 DEG C), microscopy after 4 hours.The Sporangium Germination suppression rate of compositions and each independent active component is obtained according to following formula.Compositions interaction analysis adopts foregoing Colby formula.The activity data result of each independent active component and present composition preventing and treating capsicum epidemic disease is in Table 7 and table 8.
Result shows, the observation effect value of compositions is all higher than calculating effect value.Illustrate that compositions shows as potentiation in test ratio range.
The activity of the independent active component of table 7
The activity of table 8 present composition
Claims (8)
1. a Fungicidal composition, it is characterised in that: compositions is two kinds of active components of A, B；Wherein, the weight ratio between component A and component B two component is 1:100～100:1；
Component A is selected from the compound shown in formula I:
In formula:
R1Selected from hydrogen, C1-C12Alkyl, C3-C12Cycloalkyl, halo C1-C12Alkyl, C1-C12Alkyl-carbonyl, halo C1-C12Alkyl-carbonyl, C1-C12Alkoxy carbonyl, C1-C12Alkyl amino-carbonyl, C1-C12Alkylthio group, halo C1-C12Alkylthio group, C1-C12Alkyl sulphonyl, C1-C12Alkoxy C1-C12Alkyl, C1-C12Alkoxy C1-C12Alkyl-carbonyl, C1-C12Alkoxy carbonyl C1-C12Alkyl, C1-C12Alkyl amino sulfenyl, C2-C12Dialkyl amido sulfenyl or CO-X-CO2R9, wherein X is selected from (CHR9)n、CR9=CR10Or C6H4, n=1-6；
R2Selected from halogen, halo C1-C12Alkyl, C1-C12Alkoxyl, halo C1-C12Alkoxyl, C1-C12Alkyl amino, halo C1-C12Alkyl amino, C1-C12Alkylthio group, halo C1-C12Alkylthio group, C1-C12Alkyl sulphonyl, C3-C12Cycloalkyl, C2-C12Dialkyl amido, C3-C12Alkene oxygen base, halo C3-C12Alkene oxygen base, C3-C12Alkynyloxy group, halo C3-C12Alkynyloxy group, C1-C12Alkyl-carbonyl oxygen base, C1-C12Alkyl-carbonyl-amino, C1-C12Alkyl sulphonyl oxygen base, C1-C12Alkoxy C1-C12Alkoxyl, C1-C12Alkoxy carbonyl C1-C12Alkoxyl, unsubstituted or by 1-5 R11Aryloxy group, virtue amino, arylmethyl oxygen base, arylmethyl amino, heteroaryl oxygen base or the heteroaryl amino replaced, and by R11When the number replaced is more than 1, R11May be the same or different；
R3Selected from hydrogen, halogen, nitro, cyano group, C (=O) NR9R10, C (=S) NR9R10、C1-C12Alkyl amino-carbonyl, C1-C12Alkoxy carbonyl, halo C1-C12Alkyl or C1-C12Alkyl sulphonyl；
R4、R8What may be the same or different is selected from hydrogen, halogen, cyano group, nitro, C (=O) NR9R10、C1-C12Alkyl, halo C1-C12Alkyl, C1-C12Alkoxyl, halo C1-C12Alkoxyl, C2-C12Thiazolinyl, C2-C12Alkynyl, C1-C12Alkyl sulphonyl, C1-C12Alkyl-carbonyl, C1-C12Alkoxy carbonyl, C1-C12Alkoxy C1-C12Alkyl, C1-C12Alkoxy carbonyl C1-C12Alkyl, unsubstituted or by 1-5 R11Aryl, arylmethyl, aryloxy group, virtue amino, aryl carbonyl, arylmethyl carbonyl, aryloxycarbonyl, aromatic yl aminocarbonyl or the heteroaryl oxygen base replaced, and by R11When the number replaced is more than 1, R11May be the same or different；
R5、R7What may be the same or different is selected from hydrogen, halogen, cyano group, nitro, C (=O) NR9R10、C1-C12Alkyl, halo C1-C12Alkyl, C1-C12Alkoxyl, halo C1-C12Alkoxyl, C1-C12Alkyl amino, halo C1-C12Alkyl amino, C1-C12Alkylthio group, halo C1-C12Alkylthio group, C2-C12Thiazolinyl, C2-C12Alkynyl, C1-C12Alkyl sulphonyl, C1-C12Alkyl-carbonyl, C1-C12Alkoxy carbonyl, C1-C12Alkoxy C1-C12Alkyl, C1-C12Alkoxy carbonyl C1-C12Alkyl, C1-C12Alkyl-carbonyl oxygen base, C1-C12Alkoxy-carbonyl oxy, C1-C12Alkyl amino carbonyl oxy, C1-C12Alkyl sulphonyl oxygen base, C1-C12Alkoxy C1-C12Alkoxyl, halo C1-C12Halogenated alkoxy C1-C12Alkoxyl, C1-C12Alkoxy carbonyl C1-C12Alkoxyl, unsubstituted or by 1-5 R11Aryl, arylmethyl, aryloxy group, virtue amino, aryl carbonyl, arylmethyl carbonyl, aryloxycarbonyl, aromatic yl aminocarbonyl or the heteroaryl oxygen base replaced, and by R11When the number replaced is more than 1, R11May be the same or different；
R6Selected from hydrogen, halogen, cyano group, nitro, carboxyl, C (=O) NR9R10、C1-C12Alkyl, halo C1-C12Alkyl, C1-C12Alkoxyl, halo C1-C12Alkoxyl, C2-C12Thiazolinyl, C2-C12Alkynyl, C1-C12Alkyl sulphonyl, C1-C12Alkyl-carbonyl, C1-C12Alkoxy carbonyl, C1-C12Alkoxy C1-C12Alkyl, C1-C12Alkoxy carbonyl C1-C12Alkyl, C1-C12Alkoxy C1-C12Alkoxyl, halo C1-C12Halogenated alkoxy C1-C12Alkoxyl, unsubstituted or by 1-5 R11Aryl, arylmethyl, aryloxy group, virtue amino, aryl carbonyl, arylmethyl carbonyl, aryloxycarbonyl, aromatic yl aminocarbonyl or the heteroaryl oxygen base replaced, and by R11When the number replaced is more than 1, R11May be the same or different；
But, R4、R5、R6、R7、R8It is not simultaneously selected from H；
R9、R10What may be the same or different is selected from hydrogen or C1-C6Alkyl；
R11Selected from halogen, nitro, cyano group, C1-C6Alkyl, halo C1-C6Alkyl, C1-C6Alkoxyl, halo C1-C6Alkoxyl, C1-C6Alkylthio group, C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, C2-C6Thiazolinyl, halo C2-C6Thiazolinyl, C3-C6Alkene oxygen base, halo C3-C6Alkene oxygen base, C2-C6Alkynyl, halo C2-C6Alkynyl, C3-C6Alkynyloxy group, halo C3-C6Alkynyloxy group, halo C1-C6Alkylthio group, halo C1-C6Alkyl-carbonyl, C1-C6Alkyl amino, halo C1-C6Alkyl amino, C2-C8Dialkyl amido, C1-C6Alkyl-carbonyl-amino, halo C1-C6Alkyl-carbonyl-amino, C1-C6Alkyl amino-carbonyl or halo C1-C6Alkyl amino-carbonyl；
Or the salt of compound of Formula I；
One or more in the antibacterial of amide-type of component B.
2. Fungicidal composition according to claim 1, it is characterised in that: active component A is R in formula1=H, R2=Cl, R3=NO2、R4=R8=Cl, R5=R7=H, R6=NO2Compound A1；The antibacterial of active component B amide-type is selected from flumorph B1, dimethomorph B2, fluopicolide B3, mandipropamid B4, zoxamide B5, iprovalicarb B6, cymoxanil B7, metalaxyl B8 or M 9834 B9.
3. Fungicidal composition according to claim 2, it is characterised in that: active component A is selected from compound A1；Active component B is selected from flumorph B1, dimethomorph B2, fluopicolide B3, mandipropamid B4 or zoxamide B5；Weight ratio between two kinds of active components of described A, B is 1:50～50:1.
4. Fungicidal composition according to claim 3, it is characterised in that: active component A is selected from compound A1；Active component B is selected from flumorph B1, dimethomorph B2 or fluopicolide B3；Weight ratio between two kinds of active components of described A, B is 10:1～1:40.
5. the application of the Fungicidal composition described in a claim 1, it is characterised in that: described Fungicidal composition is for preparing the medicine of preventing and treating plant pathogenic fungi disease.
6. the application of Fungicidal composition according to claim 5, it is characterised in that: the described true compositions effective ingredient as medicine that sterilizes, effective content is 0.1～95wt%.
7. the application of Fungicidal composition according to claim 5, it is characterised in that: described Fungicidal composition is configured to dispersible agent, aqueous emulsion, suspending agent, water dispersible granules or wettable powder.
8. the application of Fungicidal composition according to claim 5, it is characterised in that: described Fungicidal composition is for preparing the medicine preventing and treating plant downy mildew, peronospora tabacina, late blight, epidemic disease, balck shank or damping off.
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| CN116349685A (en) * | 2021-12-27 | 2023-06-30 | 沈阳中化农药化工研发有限公司 | Fungicidal composition containing cytoskeletal and kinesin inhibitor bactericides and application thereof |
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| WO2011076726A2 (en) * | 2009-12-23 | 2011-06-30 | Bayer Cropscience Ag | Pesticidal compound mixtures |
| CN102199095A (en) * | 2010-03-22 | 2011-09-28 | 中国中化股份有限公司 | Substituted diphenylamine compounds and preparation and application thereof |
| CN103301096A (en) * | 2012-03-14 | 2013-09-18 | 中国中化股份有限公司 | Application of substituted diphenylamine compound to preparation of antitumor drugs |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2011076726A2 (en) * | 2009-12-23 | 2011-06-30 | Bayer Cropscience Ag | Pesticidal compound mixtures |
| CN102199095A (en) * | 2010-03-22 | 2011-09-28 | 中国中化股份有限公司 | Substituted diphenylamine compounds and preparation and application thereof |
| CN103301096A (en) * | 2012-03-14 | 2013-09-18 | 中国中化股份有限公司 | Application of substituted diphenylamine compound to preparation of antitumor drugs |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116349685A (en) * | 2021-12-27 | 2023-06-30 | 沈阳中化农药化工研发有限公司 | Fungicidal composition containing cytoskeletal and kinesin inhibitor bactericides and application thereof |
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