CN105722507A - 组蛋白脱乙酰酶抑制剂与免疫调节药物的组合 - Google Patents
组蛋白脱乙酰酶抑制剂与免疫调节药物的组合 Download PDFInfo
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- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
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- 238000010186 staining Methods 0.000 description 1
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- BSYVTEYKTMYBMK-UHFFFAOYSA-N tetrahydrofurfuryl alcohol Chemical compound OCC1CCCO1 BSYVTEYKTMYBMK-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| Application Number | Priority Date | Filing Date | Title |
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| US201361889640P | 2013-10-11 | 2013-10-11 | |
| US61/889,640 | 2013-10-11 | ||
| US201361911089P | 2013-12-03 | 2013-12-03 | |
| US61/911,089 | 2013-12-03 | ||
| PCT/US2014/059387 WO2015054175A1 (en) | 2013-10-11 | 2014-10-07 | Combinations of histone deactylase inhibitors and immunomodulatory drugs |
Publications (1)
| Publication Number | Publication Date |
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| CN105722507A true CN105722507A (zh) | 2016-06-29 |
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| CN201480062094.3A Pending CN105722507A (zh) | 2013-10-11 | 2014-10-07 | 组蛋白脱乙酰酶抑制剂与免疫调节药物的组合 |
Country Status (17)
| Country | Link |
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| US (2) | US20150105358A1 (pt-PT) |
| EP (1) | EP3054939A4 (pt-PT) |
| JP (4) | JP2016532667A (pt-PT) |
| KR (1) | KR20160060143A (pt-PT) |
| CN (1) | CN105722507A (pt-PT) |
| AU (1) | AU2014332147A1 (pt-PT) |
| CA (1) | CA2926808A1 (pt-PT) |
| CL (1) | CL2016000838A1 (pt-PT) |
| CR (1) | CR20160200A (pt-PT) |
| EA (1) | EA201690753A1 (pt-PT) |
| IL (1) | IL244923A0 (pt-PT) |
| MX (1) | MX2016004604A (pt-PT) |
| NI (1) | NI201600051A (pt-PT) |
| PE (1) | PE20161342A1 (pt-PT) |
| PH (1) | PH12016500649A1 (pt-PT) |
| SG (1) | SG11201602791RA (pt-PT) |
| WO (1) | WO2015054175A1 (pt-PT) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109789138A (zh) * | 2016-10-04 | 2019-05-21 | 株式会社钟根堂 | 用于治疗血液癌症的组蛋白脱乙酰酶抑制剂和蛋白酶体抑制剂或免疫调节药物的药物组合物 |
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| JP5940984B2 (ja) | 2010-01-22 | 2016-06-29 | アセチロン ファーマシューティカルズ インコーポレイテッドＡｃｅｔｙｌｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | タンパク質デアセチラーゼ阻害剤としてのリバースアミド化合物とその使用方法 |
| ES2568260T3 (es) | 2010-11-16 | 2016-04-28 | Acetylon Pharmaceuticals, Inc. | Compuestos de pirimidin hidroxi amida como inhibidores de proteína desacetilasa y métodos de uso de los mismos |
| US9663825B2 (en) | 2012-04-19 | 2017-05-30 | Acetylon Pharmaceuticals, Inc. | Biomarkers to identify patients that will respond to treatment and treating such patients |
| US9145412B2 (en) | 2012-11-02 | 2015-09-29 | Acetylon Pharmaceuticals, Inc. | Selective HDAC1 and HDAC2 inhibitors |
| EP3054952B1 (en) * | 2013-10-08 | 2022-10-26 | Acetylon Pharmaceuticals, Inc. | Combinations of histone deacetylase 6 inhibitors and the her2 inhibitor lapatinib for use in the treatment of breast cancer |
| US9278963B2 (en) * | 2013-10-10 | 2016-03-08 | Acetylon Pharmaceuticals, Inc. | Pyrimidine hydroxy amide compounds as histone deacetylase inhibitors |
| CR20160200A (es) * | 2013-10-11 | 2016-08-29 | Acetylon Pharmaceuticals Inc | Combinaciones de inhibidores de histona desacetilasa y fármacos inmunomoduladores |
| WO2015061684A1 (en) | 2013-10-24 | 2015-04-30 | Mayo Foundation For Medical Education And Research | Treatment of polycystic diseases with an hdac6 inhibitor |
| BR112016012561A2 (pt) | 2013-12-03 | 2017-08-08 | Acetylon Pharmaceuticals Inc | Combinações de inibidores da histona desacetilase e fármacos imunomoduladores |
| US9464073B2 (en) | 2014-02-26 | 2016-10-11 | Acetylon Pharmaceuticals, Inc. | Pyrimidine hydroxy amide compounds as HDAC6 selective inhibitors |
| US9833466B2 (en) | 2014-07-07 | 2017-12-05 | Acetylon Pharmaceuticals, Inc. | Treatment of leukemia with histone deacetylase inhibitors |
| US9937174B2 (en) | 2014-12-05 | 2018-04-10 | University of Modena and Reggio Emilia | Combinations of histone deacetylase inhibitors and bendamustine |
| ES2816641T3 (es) | 2014-12-12 | 2021-04-05 | Regenacy Pharmaceuticals Inc | Derivados de piperidina en calidad de inhibidores de HDAC1/2 |
| AR104935A1 (es) | 2015-06-08 | 2017-08-23 | Acetylon Pharmaceuticals Inc | Formas cristalinas de un inhibidor de histona deacetilasa |
| EP3303304B1 (en) | 2015-06-08 | 2019-11-20 | Acetylon Pharmaceuticals, Inc. | Methods of making protein deacetylase inhibitors |
| WO2017143237A1 (en) * | 2016-02-17 | 2017-08-24 | Acetylon Pharmaceuticals, Inc. | Increasing expression of interferon regulated genes with combinatons of histone deacetylase inhibitors and immunomodulatory drugs |
| US11813261B2 (en) | 2016-04-19 | 2023-11-14 | Acetylon Pharmaceuticals, Inc. | HDAC inhibitors, alone or in combination with BTK inhibitors, for treating chronic lymphocytic leukemia |
| WO2017214565A1 (en) * | 2016-06-09 | 2017-12-14 | Dana-Farber Cancer Institute, Inc., | Methods of use and pharmaceutical combinations of hdac inhibitors with bet inhibitors |
| WO2018031472A1 (en) | 2016-08-08 | 2018-02-15 | Acetylon Pharmaceuticals Inc. | Pharmaceutical combinations of histone deacetylase 6 inhibitors and cd20 inhibitory antibodies and uses thereof |
| WO2018098168A1 (en) * | 2016-11-23 | 2018-05-31 | Acetylon Pharmaceuticals, Inc. | Pharmaceutical combinations comprising a histone deacetylase inhibitor and a programmed death-ligand 1 (pd-l1) inhibitor and methods of use thereof |
| JP7516047B2 (ja) * | 2016-11-23 | 2024-07-16 | アセチロン ファーマシューティカルズ インコーポレイテッド | ヒストン脱アセチル化酵素阻害剤とｃｄ３８阻害剤とを含む医薬組み合わせ物及びその使用方法 |
| CA3215958A1 (en) | 2021-04-23 | 2022-10-27 | Tenaya Therapeutics, Inc. | Hdac6 inhibitors for use in the treatment of dilated cardiomyopathy |
| AU2022270657A1 (en) | 2021-05-04 | 2023-11-16 | Tenaya Therapeutics, Inc. | 2-fluoroalkyl-1,3,4-oxadiazol-5-yl-thiazol, hdac6 inhibitors for use in the treatment of metabolic disease and hfpef |
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| WO2011091213A2 (en) * | 2010-01-22 | 2011-07-28 | Acetylon Pharmaceuticals | Reverse amide compounds as protein deacetylase inhibitors and methods of use thereof |
| WO2012068109A2 (en) * | 2010-11-16 | 2012-05-24 | Acetylon Pharmaceuticals | Pyrimidine hydroxy amide compounds as protein deacetylase inhibitors and methods of use thereof |
| US20130177642A1 (en) * | 2002-05-17 | 2013-07-11 | Celgene Corporation | Methods for treating multiple myeloma with 4-(amino)-2-(2,6-dioxo(3-piperidyl))-isoindoline-1,3-dione |
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| US6281230B1 (en) | 1996-07-24 | 2001-08-28 | Celgene Corporation | Isoindolines, method of use, and pharmaceutical compositions |
| US5635517B1 (en) | 1996-07-24 | 1999-06-29 | Celgene Corp | Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines |
| US7323479B2 (en) * | 2002-05-17 | 2008-01-29 | Celgene Corporation | Methods for treatment and management of brain cancer using 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline |
| CA2627923C (en) | 2005-11-10 | 2016-01-12 | Topotarget Uk Limited | Histone deacetylase (hdac) inhibitors (pxdlol) for the treatment of cancer |
| WO2013013113A2 (en) * | 2011-07-20 | 2013-01-24 | The General Hospital Corporation | Histone deacetylase 6 selective inhibitors for the treatment of bone disease |
| CR20160200A (es) * | 2013-10-11 | 2016-08-29 | Acetylon Pharmaceuticals Inc | Combinaciones de inhibidores de histona desacetilasa y fármacos inmunomoduladores |
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2014
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- 2014-10-07 KR KR1020167011860A patent/KR20160060143A/ko not_active Application Discontinuation
- 2014-10-07 CN CN201480062094.3A patent/CN105722507A/zh active Pending
- 2014-10-07 SG SG11201602791RA patent/SG11201602791RA/en unknown
- 2014-10-07 MX MX2016004604A patent/MX2016004604A/es unknown
- 2014-10-07 JP JP2016521758A patent/JP2016532667A/ja active Pending
- 2014-10-07 AU AU2014332147A patent/AU2014332147A1/en not_active Abandoned
- 2014-10-07 PE PE2016000490A patent/PE20161342A1/es not_active Application Discontinuation
- 2014-10-07 EA EA201690753A patent/EA201690753A1/ru unknown
- 2014-10-07 WO PCT/US2014/059387 patent/WO2015054175A1/en active Application Filing
- 2014-10-07 CA CA2926808A patent/CA2926808A1/en not_active Abandoned
- 2014-10-07 US US14/508,072 patent/US20150105358A1/en not_active Abandoned
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2016
- 2016-04-05 IL IL244923A patent/IL244923A0/en unknown
- 2016-04-08 PH PH12016500649A patent/PH12016500649A1/en unknown
- 2016-04-11 NI NI201600051A patent/NI201600051A/es unknown
- 2016-04-11 CL CL2016000838A patent/CL2016000838A1/es unknown
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2018
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2019
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2021
- 2021-02-12 JP JP2021020680A patent/JP2021073314A/ja active Pending
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2023
- 2023-10-26 JP JP2023184173A patent/JP2024010118A/ja active Pending
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| WO2011091213A2 (en) * | 2010-01-22 | 2011-07-28 | Acetylon Pharmaceuticals | Reverse amide compounds as protein deacetylase inhibitors and methods of use thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109789138A (zh) * | 2016-10-04 | 2019-05-21 | 株式会社钟根堂 | 用于治疗血液癌症的组蛋白脱乙酰酶抑制剂和蛋白酶体抑制剂或免疫调节药物的药物组合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3054939A4 (en) | 2017-12-13 |
| JP7403950B2 (ja) | 2023-12-25 |
| KR20160060143A (ko) | 2016-05-27 |
| WO2015054175A1 (en) | 2015-04-16 |
| CR20160200A (es) | 2016-08-29 |
| PH12016500649A1 (en) | 2016-05-30 |
| EP3054939A1 (en) | 2016-08-17 |
| AU2014332147A1 (en) | 2016-05-05 |
| IL244923A0 (en) | 2016-05-31 |
| JP2016532667A (ja) | 2016-10-20 |
| JP2024010118A (ja) | 2024-01-23 |
| CA2926808A1 (en) | 2015-04-16 |
| US20150105358A1 (en) | 2015-04-16 |
| US20200323849A1 (en) | 2020-10-15 |
| SG11201602791RA (en) | 2016-05-30 |
| EA201690753A1 (ru) | 2016-07-29 |
| CL2016000838A1 (es) | 2016-11-25 |
| JP2021073314A (ja) | 2021-05-13 |
| PE20161342A1 (es) | 2016-12-31 |
| NI201600051A (es) | 2017-07-11 |
| MX2016004604A (es) | 2016-08-01 |
| JP2019052171A (ja) | 2019-04-04 |
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