CN105717090B - A kind of integrated total internal reflection micro-fluidic chip detection all-in-one machine - Google Patents
A kind of integrated total internal reflection micro-fluidic chip detection all-in-one machine Download PDFInfo
- Publication number
- CN105717090B CN105717090B CN201610296065.4A CN201610296065A CN105717090B CN 105717090 B CN105717090 B CN 105717090B CN 201610296065 A CN201610296065 A CN 201610296065A CN 105717090 B CN105717090 B CN 105717090B
- Authority
- CN
- China
- Prior art keywords
- total internal
- internal reflection
- mainframe box
- control cabinet
- machine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000001514 detection method Methods 0.000 title claims abstract description 28
- 238000012545 processing Methods 0.000 claims abstract description 20
- 230000003287 optical effect Effects 0.000 claims abstract description 18
- 230000005284 excitation Effects 0.000 claims abstract description 8
- 239000013307 optical fiber Substances 0.000 claims abstract description 8
- 239000010410 layer Substances 0.000 claims description 16
- 239000011229 interlayer Substances 0.000 claims description 13
- 238000004887 air purification Methods 0.000 claims description 7
- 238000005192 partition Methods 0.000 claims description 7
- 238000004140 cleaning Methods 0.000 claims description 4
- 238000009423 ventilation Methods 0.000 claims description 4
- 239000012774 insulation material Substances 0.000 claims description 3
- 238000005516 engineering process Methods 0.000 abstract description 7
- 238000013461 design Methods 0.000 abstract description 5
- 230000006835 compression Effects 0.000 abstract description 2
- 238000007906 compression Methods 0.000 abstract description 2
- 238000000034 method Methods 0.000 description 3
- 208000002925 dental caries Diseases 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 238000000799 fluorescence microscopy Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 238000000492 total internal reflection fluorescence microscopy Methods 0.000 description 1
- 230000005945 translocation Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6402—Atomic fluorescence; Laser induced fluorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
Landscapes
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Optics & Photonics (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Microscoopes, Condenser (AREA)
Abstract
The invention discloses a kind of integrated total internal reflection micro-fluidic chips to detect all-in-one machine, it is made of mainframe box, control cabinet and processing display three parts, processing display is connected with inverted microscope, the total internal reflection optical receiver circuit in mainframe box, is also connected with sample injector, the cold and hot compression machine circuit in control cabinet.Optical fiber excitation light source and incident light angle calibration scale are also equipped in mainframe box.Compared with the existing technology, total internal reflection incidence angle can rapidly be adjusted to the present invention by having, to the adaptable of detection chip, the advantages of variety classes and the micro-fluidic chip of different designs can be used.Function is integrated higher, realize the temperature of detection zone uniformly with it is constant, humidity it is uniform with it is constant, detection and experiment under condition of different temperatures can be met.
Description
Technical field
The present invention relates to a kind of in-vitro diagnosis all-in-one machines, more specifically belong to the external diagnostic field of Medical Devices
A kind of integrated total internal reflection micro-fluidic chip detection all-in-one machine.
Background technology
TOTAL INTERNAL REFLECTION FLUORESCENCE MICROSCOPY is a kind of emerging in recent years optical image technology, it is generated using total internal reflection
Evanescent field illuminates sample, to causing the fluorogen in the optical layers of hundred nano-scale thickness to be excited, fluorescence imaging
Signal-to-noise ratio is very high.The imaging device of this method is simple, is easily combined with other imaging techniques, Detection Techniques.It has become at present
Spatial resolution even lower 100 nm of realization of work(.And micro-fluidic chip is rapidly developed at present, and today is hindered
The problem of bottleneck of microflow control technique development is still application aspect.Total internal reflection optical detection technique be exactly one meet with it is micro-
The integrated optical detective technology of fluidic chip.But the all-in-one machine at present integrating the two is also more rare, lacks the two technology
Integrated detection equipment.
For the disposable inspection of the multiple protein factor to cancer and cardiovascular and cerebrovascular disease and a variety of great malignant diseases
Diagnosis is surveyed, a kind of integrated total internal reflection micro-fluidic chip detection all-in-one machine is needed.
Invention content
It is an object of the invention to overcome the deficiencies of the prior art and provide a kind of integrated total internal reflection micro-fluidic chips to examine
Survey all-in-one machine.
The object of the present invention is achieved like this：A kind of integrated total internal reflection micro-fluidic chip detection all-in-one machine, by leading
Cabinet, control cabinet and processing display composition, it is characterised in that：Host babinet is vertical facing forward to have opening, opening peace on one side
Equipped with door, there are one interlayer cavitys for back side wall；Box house is divided into upper layer and lower layer by partition board, and it is micro- that inversion is equipped in lower layer's case
Mirror, placement inverted microscope is to meet a tractor serves several purposes purpose, enough total internal reflections detection and can be examined with inverted microscope
It surveys.Against observation window above inverted microscope camera lens；The upper surface of partition board above observation window is equipped with sample stage；On a sample stage left side
Right both sides correspond to and are equipped with 2 optical fiber excitation light sources, each to install on the tank wall of 2 optical fiber excitation light source behinds
There is 1 incident light angle calibration scale.In this way design can fast tuning incident light angle, quickly carry out total reflection detection.Sample
There are total internal reflection optical receiver in fixed placement detection chip in sample platform, detection chip surface.The back side babinet of chamber on upper layer
Perpendicular rail is installed on wall, is also horizontally installed with traverse rod on perpendicular rail, traverse rod is mutually perpendicular to perpendicular rail right-angled intersection；Total internal reflection light
Receiver is connect by Universal rotary head with transverse arm, and transverse arm is fixed on perpendicular rail or traverse rod.Design disclosure satisfy that total internal reflection in this way
Optical receiver is vertically moved and is fixed on perpendicular rail；Total internal reflection optical receiver can also be met to move left and right on traverse rod
And fixation；Certain angle can also be reversed by Universal rotary head, guarantee quickly to adjust good position, so that total internal reflection is detected suitable
Profit carries out.On the back side box body wall of upper layer chamber, the humidifier for being equipped with disjunctor and humidity sensor and humidity sense are also processed
Device is answered to control fan, to have ensured that living cells detects the constant of required humidity.Processing is equipped with air at the top of mainframe box
Purifier is communicated by air purification ventilation filter hole with internal chamber.Processing is equipped with air purification dress at the top of mainframe box
It sets and is communicated with chamber, ensured the cleannes requirement in monitoring region.It is control cabinet on the right side of host babinet, is connected with host babinet.
Processing display is placed on the table top of control cabinet.Calibrating gas bottle, sample injector, cold and hot compressor are installed inside control cabinet.Processing
Display is connected with inverted microscope, the total internal reflection optical receiver circuit in mainframe box body, also in control cabinet sample injector,
Cold and hot compression machine circuit is connected.Processing display can control these devices.Cold and hot compressor is empty by hot and cold air duct and interlayer
Chamber is connected；Interlayer cavity is connected by filter hole with air cleaning unit.
Further, humidity sensor control fan is communicated with interlayer cavity, ensured the temperature of chamber uniformly with
It is constant, humidity it is uniform with it is constant.
Further, the host babinet is the closed case processed by transparent, thermal insulation material；The opening installation
Door is transparent and closed thermal insulating door thermally insulated door.This ensure that temperature, humidity in case it is uniform with it is constant.
Further, the inverted microscope is inverted fluorescence microscope or inverted phase contrast microscope, is met so different
The detection of sample needs.The control cabinet is independent case body, can be fastened with mainframe box and couple or split, the height of control cabinet is
1/2 or more of host box height.
The present invention has the following advantages compared with the prior art.
1. total internal reflection incidence angle can be adjusted rapidly, to the adaptable of detection chip, variety classes can be used,
With the micro-fluidic chip of different designs.
It can be detected again with conventional microscopy 2. can be detected with total internal reflection techniques, realize that a tractor serves several purposes, a machine translocation are more
The requirement of the different protein factor of kind.
3. combining the integration with all-in-one machine by two kinds of total internal reflection detection technique, microfluidic chip technology technologies, realize
The temperature of detection zone uniformly with it is constant, humidity it is uniform with it is constant.
Description of the drawings
Fig. 1 is the schematic front view of the present invention.
Fig. 2 is the left view schematic diagram of the present invention.
Wherein：1. mainframe box；2. inverted microscope；3. observation window；4. partition board；5. sample stage；6. incident light angle is calibrated
Scale；7. optical fiber excitation light source；8. humidifier and humidity sensor；9. humidity sensor controls fan；10. anti-in complete
Penetrate optical receiver；11. air cleaning unit；12. perpendicular rail；13. traverse rod；14. detection chip；15. processing display；16. leading
Pipe；17. calibrating gas bottle；18. sample injector；19. control cabinet；20. cold and hot compressor；21. hot and cold air duct；22. interlayer cavity；23.
Filter hole；24. air purification ventilation filter hole；25. transverse arm；26. Universal rotary head.
Specific implementation mode
Referring to Fig. 1-2, a kind of integrated total internal reflection micro-fluidic chip detection all-in-one machine, by mainframe box 1,19 and of control cabinet
Processing display 15 forms, it is characterised in that：Mainframe box 1 is vertical facing forward to have opening, opening to be equipped with door on one side.Back side wall
There are one interlayer cavitys 22.Box house is divided by partition board 4 for upper layer and lower layer, and inverted microscope 2 is equipped in lower layer's case.Placement is fallen
It is to meet a tractor serves several purposes purpose to set microscope, enough total internal reflections detection and can be detected with inverted microscope.It is inverted aobvious
Sample stage 5 is installed against observation window 3, the upper surface of the partition board 4 of 3 top of observation window above 2 camera lens of micro mirror.In sample stage 5 or so
Both sides correspond to and are equipped with 2 optical fiber excitation light sources 7, each to install on the tank wall of 27 behinds of optical fiber excitation light source
There is 1 incident light angle calibration scale 6.Fixed placement detection chip 14 on sample stage 5,14 surface of detection chip have anti-in complete
Penetrate optical receiver 10.Perpendicular rail 12 is installed on the back side box body wall of upper layer chamber, traverse rod is also horizontally installed on perpendicular rail 12
13, traverse rod 13 is mutually perpendicular to 12 right-angled intersection of perpendicular rail.Total internal reflection optical receiver 10 is connected by Universal rotary head 26 and transverse arm 25
It connects, transverse arm 25 is fixed on perpendicular rail 12 or traverse rod 13.Design disclosure satisfy that total internal reflection optical receiver 10 on perpendicular rail 12 in this way
It vertically moves and fixes, additionally it is possible to meet total internal reflection optical receiver 10 and move left and right and fix on traverse rod 13, moreover it is possible to
Certain angle is reversed by Universal rotary head 26, guarantees quickly to adjust good position, makes being smoothed out for total internal reflection detection.
On the back side box body wall of upper layer chamber, the humidifier for being equipped with disjunctor and humidity sensor 8 and humidity sensor control are also processed
Fan 9, to have ensured that living cells detects the constant of required humidity.Air purification dress is installed in 1 top processing of mainframe box
11 are set to communicate with internal chamber by air purification ventilation filter hole 24.Air purification dress is installed in 1 top processing of mainframe box
It sets 11 to communicate with chamber, has ensured the cleannes requirement in monitoring region.1 right side of mainframe box is control cabinet 19, with 1 phase of mainframe box
Even.Processing display 15 is placed on the table top of control cabinet 19；Calibrating gas bottle 17, sample injector 18, cold is installed inside control cabinet 19
Thermocompressor 20.Processing display 15 is connected with 1 inverted microscope 2,10 circuit of total internal reflection optical receiver in mainframe box body,
Also it is connected with sample injector 18,20 circuit of cold and hot compressor in control cabinet 19.Processing display can control these connected dresses
It sets.Cold and hot compressor 20 is connected by hot and cold air duct 21 with interlayer cavity 22；Interlayer cavity 22 is net by filter hole 23 and air
Makeup sets 11 and is connected.
Further, the humidity sensor control fan 9 is communicated with interlayer cavity 22, has ensured that the temperature of chamber is uniform
With it is constant, humidity it is uniform with it is constant.
Further, the mainframe box 1 is the closed case processed by transparent, thermal insulation material；The opening installation
Door is transparent and closed thermal insulating door thermally insulated door.This ensure that temperature, humidity in case it is uniform with it is constant.
Further, the inverted microscope 2 is inverted fluorescence microscope or inverted phase contrast microscope.Meet so not
Detection with sample needs.The control cabinet 19 is independent case body, can be fastened with mainframe box 1 and couple or split, control cabinet 19
Height be 1/2 or more of 1 height of mainframe box.
Claims (4)
1. a kind of integrated total internal reflection micro-fluidic chip detects all-in-one machine, by mainframe box（1）, control cabinet（19）It is shown with processing
Device（15）Composition, it is characterised in that：Mainframe box（1）It is vertical it is facing forward have opening, opening that door is installed on one side, back side wall has one
A interlayer cavity（22）；Box house is by partition board（4）It is divided into upper layer and lower layer, inverted microscope is installed in lower layer's case（2）, it is inverted
Microscope（2）Against observation window above camera lens（3）；Observation window（3）The partition board of top（4）The upper surface of sample stage is installed（5）；
Sample stage（5）The left and right sides corresponds to and is equipped with 2 optical fiber excitation light sources（7）, in 2 optical fiber excitation light sources（7）The back of the body
On tank wall afterwards, 1 incident light angle calibration scale is respectively installed（6）；Sample stage（5）Upper fixed placement detection chip（14）,
Detection chip（14）There is total internal reflection optical receiver in surface（10）；Perpendicular rail is installed on the back side box body wall of upper layer chamber
（12）, in perpendicular rail（12）On be also horizontally installed with traverse rod（13）, traverse rod（13）With perpendicular rail（12）Right-angled intersection is mutually perpendicular to；In complete
Reflect optical receiver（10）Pass through Universal rotary head（26）With transverse arm（25）Connection；Transverse arm（25）It is fixed on perpendicular rail（12）Or traverse rod
（13）On；On the back side box body wall of upper layer chamber, also processing is equipped with the humidifier and humidity sensor of disjunctor（8）And humidity
Inductor controls fan（9）；In mainframe box（1）Top of the box processing air cleaning unit is installed（11）Pass through air purification
Ventilation filter hole（24）It is communicated with internal chamber；Mainframe box（1）Right side is control cabinet（19）, with mainframe box（1）It is connected；Processing is aobvious
Show device（15）It is placed on control cabinet（19）Table top on；Control cabinet（19）Inside is equipped with calibrating gas bottle（17）, sample injector（18）, it is cold
Thermocompressor（20）；Processing display（15）With mainframe box（1）Interior inverted microscope（2）, total internal reflection optical receiver（10）
Circuit is connected, and also and control cabinet（19）Interior sample injector（18）, cold and hot compressor（20）Circuit is connected；Cold and hot compressor（20）It is logical
Cross hot and cold air duct（21）With interlayer cavity（22）It is connected；Interlayer cavity（22）Pass through filter hole（23）With air cleaning unit（11）
It is connected.
2. a kind of integrated total internal reflection micro-fluidic chip according to claim 1 detects all-in-one machine, it is characterised in that：Institute
State humidity sensor control fan（9）With interlayer cavity（22）It communicates.
3. a kind of integrated total internal reflection micro-fluidic chip according to claim 1 detects all-in-one machine, it is characterised in that：Institute
State mainframe box（1）It is the closed case processed by transparent, thermal insulation material；The opening is equipped with door, and door is transparent and close
The thermal insulating door thermally insulated door closed.
4. a kind of integrated total internal reflection micro-fluidic chip according to claim 1 detects all-in-one machine, it is characterised in that：Institute
State inverted microscope（2）It is inverted fluorescence microscope or inverted phase contrast microscope；The control cabinet（19）It is independent case body, energy
Enough and mainframe box（1）It fastens connection or splits, control cabinet（19）Height be mainframe box（1）1/2 or more of height.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610296065.4A CN105717090B (en) | 2016-05-08 | 2016-05-08 | A kind of integrated total internal reflection micro-fluidic chip detection all-in-one machine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610296065.4A CN105717090B (en) | 2016-05-08 | 2016-05-08 | A kind of integrated total internal reflection micro-fluidic chip detection all-in-one machine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105717090A CN105717090A (en) | 2016-06-29 |
| CN105717090B true CN105717090B (en) | 2018-07-31 |
Family
ID=56162019
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610296065.4A Active CN105717090B (en) | 2016-05-08 | 2016-05-08 | A kind of integrated total internal reflection micro-fluidic chip detection all-in-one machine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105717090B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106680258A (en) * | 2017-02-09 | 2017-05-17 | 重庆科技学院 | Total internal reflection detection workbench |
| WO2019153260A1 (en) * | 2018-02-09 | 2019-08-15 | 深圳达闼科技控股有限公司 | Auxiliary raman detection apparatus, raman detection terminal and method |
| CN110568203B (en) * | 2019-09-12 | 2022-05-24 | 重庆科技学院 | Application method of multi-channel fluorescence immunochromatographic microfluidic chip |
| CN111004721A (en) * | 2019-12-24 | 2020-04-14 | 南通大学 | Ultrathin visual temperature control device suitable for microscope online in-situ observation |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012025220A1 (en) * | 2010-08-23 | 2012-03-01 | Euroimmun Medizinische Labordiagnostika Ag | Method and device for focusing substrates in an automated manner in fluorescence microscopy |
| CN102954938A (en) * | 2011-08-29 | 2013-03-06 | 中国科学院电子学研究所 | Absorption luminosity detecting sensor based on micro-fluid control channel full-reflection integration light waveguide |
| CN103235406A (en) * | 2013-04-27 | 2013-08-07 | 中国科学院化学研究所 | Total internal reflection illumination and semi-total internal reflection illumination dual optical path fluorescence microscope system |
| CN103604775A (en) * | 2013-07-04 | 2014-02-26 | 丹阳聚辰光电科技有限公司 | Microbiological detection instrument based on micro-fluidic chip and SPR detection method thereof |
| WO2014109501A1 (en) * | 2013-01-09 | 2014-07-17 | 성균관대학교산학협력단 | Fluorescence detection device using total internal reflector |
| CN104568883A (en) * | 2014-12-31 | 2015-04-29 | 中国科学院深圳先进技术研究院 | Fiber coupling total internal reflection fluorescence microscopic imaging chip |
| CN205593924U (en) * | 2016-05-08 | 2016-09-21 | 重庆科技学院 | It detects all -in -one to integrate total internal reflection micro -fluidic chip |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8329117B2 (en) * | 2009-05-14 | 2012-12-11 | Canon U.S. Life Sciences, Inc. | Microfluidic chip features for optical and thermal isolation |
| US9074980B2 (en) * | 2011-01-20 | 2015-07-07 | Industry-University Corporation Foundation Hanyang University | Method for the toxicity assessments of nano-materials |
-
2016
- 2016-05-08 CN CN201610296065.4A patent/CN105717090B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012025220A1 (en) * | 2010-08-23 | 2012-03-01 | Euroimmun Medizinische Labordiagnostika Ag | Method and device for focusing substrates in an automated manner in fluorescence microscopy |
| CN102954938A (en) * | 2011-08-29 | 2013-03-06 | 中国科学院电子学研究所 | Absorption luminosity detecting sensor based on micro-fluid control channel full-reflection integration light waveguide |
| WO2014109501A1 (en) * | 2013-01-09 | 2014-07-17 | 성균관대학교산학협력단 | Fluorescence detection device using total internal reflector |
| CN103235406A (en) * | 2013-04-27 | 2013-08-07 | 中国科学院化学研究所 | Total internal reflection illumination and semi-total internal reflection illumination dual optical path fluorescence microscope system |
| CN103604775A (en) * | 2013-07-04 | 2014-02-26 | 丹阳聚辰光电科技有限公司 | Microbiological detection instrument based on micro-fluidic chip and SPR detection method thereof |
| CN104568883A (en) * | 2014-12-31 | 2015-04-29 | 中国科学院深圳先进技术研究院 | Fiber coupling total internal reflection fluorescence microscopic imaging chip |
| CN205593924U (en) * | 2016-05-08 | 2016-09-21 | 重庆科技学院 | It detects all -in -one to integrate total internal reflection micro -fluidic chip |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105717090A (en) | 2016-06-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105717090B (en) | A kind of integrated total internal reflection micro-fluidic chip detection all-in-one machine | |
| CN103080807B (en) | Be used for carrying out self-focusing method and apparatus to nutrient culture media in fluorescence microscopy | |
| US9651508B2 (en) | Thermal contrast assay and reader | |
| CN1696674B (en) | Method for reconstructing chromatography image of image of infrared heat wave detection | |
| CN108593416A (en) | Micro-nano particle detection systems and method | |
| WO2014189624A1 (en) | Digital control of on-chip magnetic particle assay | |
| ITCZ990010A1 (en) | METHODS AND EQUIPMENT FOR MEASURING THE THREE-DIMENSIONAL DISTRIBUTION OF TEMPERATURES INSIDE DIELECTRIC MEDIA. | |
| EP4028942A1 (en) | Systems and methods for artificial intelligence based cell analysis | |
| CN104764713B (en) | Terahertz thermal transient image checking and chromatographic imaging system and method | |
| EP2856115A1 (en) | Apparatus and method for measuring physiologically active substance of biological origin | |
| CN103393404A (en) | Multi-wavelength infrared polarized light real-time image guide system | |
| CN108061727A (en) | A kind of thyroglobulin quantitative testing test paper item and preparation method thereof | |
| TW200923361A (en) | Electronic inspection device and inspection method thereof | |
| TW201520534A (en) | Fluorescence strip, fluorescence excitation device and portable fluorescence analysis system with the same | |
| US9983197B2 (en) | Low-cost portable microfluidic system for cell migration | |
| CN106338498A (en) | Water content distribution detection device and application thereof | |
| CN108007863A (en) | Test device, tests the control method of system and test device | |
| CN205593924U (en) | It detects all -in -one to integrate total internal reflection micro -fluidic chip | |
| CN105891178B (en) | A kind of integrated total internal reflection micro-fluidic chip detection all-in-one machine application method | |
| CN108535482A (en) | A kind of antibody chip kit for tumour early screening and diagnosis | |
| CN210514032U (en) | Synchronous detection device combining immune detection and leukocyte counting | |
| US20070248140A1 (en) | Optical Dilatometer | |
| CN205826513U (en) | A kind of blood sample provides device and platelet aggregation detector thereof | |
| WO2021057792A1 (en) | Particulate matter sensor and vehicle air conditioner assembly | |
| CN105784644B (en) | A kind of constant temperature total internal reflection micro-fluidic chip detection all-in-one machine application method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| OL01 | Intention to license declared | ||
| OL01 | Intention to license declared |