CN105707885A - Health product with liver repairing function and preparation method - Google Patents
Health product with liver repairing function and preparation method Download PDFInfo
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- CN105707885A CN105707885A CN201610076062.XA CN201610076062A CN105707885A CN 105707885 A CN105707885 A CN 105707885A CN 201610076062 A CN201610076062 A CN 201610076062A CN 105707885 A CN105707885 A CN 105707885A
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention provides a health product with a liver repairing function and a preparation method. The health product comprises the components in parts by weight: 20-30 parts of antradiacomphora, 10-20 parts of propolis, 25-30 parts of semen hoveniae, 30-35 parts of schisandra chinensis, 15-20 parts of root of kudzu vine, 25-30 parts of grape pip, 15-20 parts of dahurian patrinia herb, 20-25 parts of pseudo-ginseng, 15-20 parts of radix codonopsis, 25-30 parts of astragalus membranaceus, 20-25 parts of phosphoesterases complex and 30-35 parts of starch. The preparation method comprises the steps of preparing materials, extracting active ingredients of crude drugs of traditional Chinese medicine, pelletizing, granulating and packaging into a capsule. The health product provided by the invention has the effects of clearing heat and removing toxicity, promoting blood circulation and dissolving stasis, sterilizing and diminishing inflammation and improving human immunity, and thus an injured liver can be effectively repaired. The components are good in synergistic effect; after the health product is used, the injured liver can be effectively repaired; the active ingredients are good in absorption and high in bioavailability.
Description
Technical field
The invention belongs to health product technology field, be a kind of health product with liver repair function and preparation method concretely.
Background technology
Liver is the parenchymatous organ that intraperitoneal is maximum, undertakes the important physiological function of human body, and hepatocyte is poor to the tolerance of anoxia, therefore has Hepatic artery and portal vein to provide the blood supply enriched, and has size bile duct and blood vessel companion's row conveying bile.It is positioned at the deep of upper right abdomen, has the protection of lower thoracic wall and diaphram.In recent years, change along with people life style and diet structure, the sickness rate of the hyperlipemia-fatty liver (non-alcoholic fatty liver disease) caused by the factors such as obesity increases day by day, and likely develops into fat hepatitis, fatty cirrhosis, there is no definite therapeutic scheme at present.
The survival rate of the patient suffering from liver failure or insufficient liver mass after hepar damnification or resection operation is being made great efforts to improve in regenerative medicine field.In little clinical case, when the patient with these situations is treated, separator bar between success and failure is it is apparent that the successful liver after damage recovers generally to bring Health restoration completely therewith, but the recovery of failure causes needing liver transplantation or death.In liver regeneration or reparation, improving of even small increase is all probably abundance from death to the healthy result recovered completely to changing.In the patient suffering from acute hepatic failure, strengthen the ability repaired the situation of expendable liver can be converted to affected liver can the situation of complete recovery of health.Suffer from that Thailand's (acetaminophen) is excessive every year in the U.S., colony that acute viral hepatitis or other infectious cause, metabolism disorder or toxicity stimulate includes 20,000 patients (Hoofnagle et al., 1995).The patient that suffers these diseases painful usually young and there is seldom other medical symptom, if thus affected liver can be induced to recover or regeneration, it is likely that produce to recover completely.The patient population standing operation on liver is likely to experience microhepatia syndrome.When using complete organ, the organ of segmentation or liver donor, this occurs in cancer resection art or after transplanting.In many this situations, this remaining liver mass is not enough to support life.This microhepatia syndrome is shown as transplant dysfunction and may result in death (Tucker and Heaton, 2005).Owing to being difficult to the liver mass after predicting excision, the patient suffering from hepatocarcinoma is frequently not the candidate for liver resection.The patient of hepatocarcinoma is diagnosed as more than 500,000 (500000) (Parkin et al., 2002) in the annual whole world, and almost 80% is confirmed as unresectable (Zhu et al., 2006) when diagnosis.But if carried out excision, these patients are likely to develop into hyperbilirubinemia (i.e. jaundice) and be eventually developed to liver failure.Owing to being very limited amount of for other selection of cancer patient, for more suffering from the patient of otherwise unresectable hepatocarcinoma, the potential treatment for strengthening or increase liver regeneration or reparation will greatly increase the probability of liver resection.
Summary of the invention
In order to damaged liver is effectively repaired, the invention provides a kind of health product with liver repair function, the present invention adopts the method for heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, bactericidal antiphlogistic, raising body immunity, and damaged liver is effectively repaired.
The present invention seeks to be realized by techniques below scheme:
A kind of health product with liver repair function, component and the parts by weight of these health product include: Antrodia camphorata 20～30 parts, propolis 10～20 parts, Semen Hoveniae (Fructus Hoveniae) 25～30 parts, Fructus Schisandrae Chinensis 30～35 parts, Radix Puerariae 15～20 parts, Semen Vitis viniferae 25～30 parts, Herba Patriniae 15～20 parts, 20～25 parts of Radix Notoginseng, Radix Codonopsis 15～20 parts, the Radix Astragali 25～30 parts, phosphoesterases complex 20～25 parts, starch 30～35 parts.
Further, the object of the invention can also be realized by techniques below scheme:
A kind of health product with liver repair function, component and the parts by weight of these health product include: Antrodia camphorata 20 parts, propolis 10 parts, Semen Hoveniae (Fructus Hoveniae) 25 parts, Fructus Schisandrae Chinensis 30 parts, Radix Puerariae 15 parts, Semen Vitis viniferae 25 parts, Herba Patriniae 15 parts, 20 parts of Radix Notoginseng, Radix Codonopsis 15 parts, the Radix Astragali 25 parts, phosphoesterases complex 20 parts, starch 30 parts.
A kind of health product with liver repair function, component and the parts by weight of these health product include: Antrodia camphorata 30 parts, propolis 20 parts, Semen Hoveniae (Fructus Hoveniae) 30 parts, Fructus Schisandrae Chinensis 35 parts, Radix Puerariae 20 parts, Semen Vitis viniferae 30 parts, Herba Patriniae 20 parts, 25 parts of Radix Notoginseng, Radix Codonopsis 20 parts, the Radix Astragali 30 parts, phosphoesterases complex 25 parts, starch 35 parts.
A kind of health product with liver repair function, component and the parts by weight of these health product include: Antrodia camphorata 25 parts, propolis 17 parts, Semen Hoveniae (Fructus Hoveniae) 29 parts, Fructus Schisandrae Chinensis 31 parts, Radix Puerariae 16 parts, Semen Vitis viniferae 28 parts, Herba Patriniae 17 parts, 23 parts of Radix Notoginseng, Radix Codonopsis 19 parts, the Radix Astragali 27 parts, phosphoesterases complex 24 parts, starch 32 parts.
The preparation method that present invention also offers a kind of health product with liver repair function, comprises the following steps:
1) getting the raw materials ready, get the raw materials ready according to described component and parts by weight, Antrodia camphorata pulverized 100 mesh sieves；
2) extraction of raw material of Chinese medicine pharmaceutically active ingredient, the water that parts by weight are raw material of Chinese medicine medicine parts by weight 10 times is added in Chinese medicine extracting tank, open stirring, raw material of Chinese medicine medicine Semen Hoveniae (Fructus Hoveniae), Fructus Schisandrae Chinensis, Radix Puerariae, Semen Vitis viniferae, Herba Patriniae, Radix Notoginseng, Radix Codonopsis, the Radix Astragali are added in Chinese medicine extracting tank, temperature of charge in Chinese medicine extracting tank is warming up to 85～90 DEG C, constant temperature extracts 1h, filters, and filtrate is standby；Adding in Chinese medicine extracting tank by the water that parts by weight are raw material of Chinese medicine medicine parts by weight 10 times, open stirring, added by filtering residue in Chinese medicine extracting tank, the temperature of charge in Chinese medicine extracting tank is warming up to 85～90 DEG C, constant temperature extracts 1h, filters, and filtrate is standby；Merge twice gained filtrate, vacuum be concentrated into former filtrate volume 1/5th the concentrated liquid of tradition Chinese medicine；
3) granulate, by step 2) gained the concentrated liquid of tradition Chinese medicine, Antrodia camphorata, propolis, phosphoesterases complex, starch mix homogeneously, wet granulation, drying equipment used is fluid bed, process conditions are: temperature of charge is 40 DEG C～45 DEG C, inlet temperature is 65 DEG C～70 DEG C, and wind speed is 650rpm～700rpm, and air outlet temperature is 30 DEG C～35 DEG C；
4) granulate, by step 2) gained granule crosses 20～40 mesh sieve granulate；
5) dress capsule, by step 3) gained granule dress capsule, specification is 0.5～1g/ grain.
Further, the preparation method of a kind of health product with liver repair function of the present invention, described step 2) process conditions of vacuum concentration are: pressure is-0.07～-0.08Mpa, temperature is 45～50 DEG C.
In order to damaged liver is effectively repaired, component each in formula, through a large amount of screening tests, is screened by the present invention, the method adopting heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, bactericidal antiphlogistic, raising body immunity, and damaged liver is effectively repaired.
Specifically, selected component:
Antrodia camphorata, fragrant odour, acrid in the mouth, hardship；Containing multiple physiologically active ingredient in Antrodia camphorata, such as polysaccharide, triterpenoid compound, sudismase (SOD) adenosine, protein (containing immune protein), multivitamin, trace element (calcium, phosphorus, paper mulberry), nucleic acid, agglutinin, aminoacid, cholesterol, lignin, blood pressure stabilization material etc..It physiological active functions possessed has antitumor, enhancing immunity, antiviral, antiallergic, resisting hypertension, suppression platelet aggregation, blood pressure lowering, cholesterol reducing, antibacterium, the liver protecting etc..
Propolis, bitter in the mouth, pungent, cold in nature.Removing toxic substances sore, invigorates blood circulation and disappears.Main component has flavone compound and terpene compound etc., and it has the several functions such as antibacterial, antiinflammatory, antipruritic, antioxidation, enhancing immunity, blood sugar lowering, blood fat reducing, antitumor, and human body has medical treatment widely, health-care effect.Propolis is the resin that Apis gathers from the tree position such as bud, bark of long glue source plant, then mixes the secretions with bodies of gland such as Apis lingual gland and wax glands, through a kind of colloid substance of Apis metabolism repeatedly synthesis.Propolis is reddish brown to green brown powder, or resin-like is block, savory.There is waxiness to separate during heating, be dispersed among in water, have surfactant concurrently and make.
Semen Hoveniae (Fructus Hoveniae), Japanese raisintree fruit (Semenhoveniae) is the seed of Rhamnaceae (Rhamnaceae) Hovenia (Hovenia) plant trifoliate orange (HoveniadulcisThunb), has relieving restlessness of quenching the thirst, alcoholic intoxication, convenient effect.The methanolic extract of Japanese raisintree fruit can improve glutathione (GSH) oxidative function of acute hepatic injury mice, strengthen the GSH association reaction of glutathione transferring enzyme (GST) catalysis, increase superoxide dismutase, catalase activity, the acute liver caused by antagonism ethanol.It is reported, 75% ethanol extraction of Japanese raisintree fruit has the effect of anti-hepatic fibrosis, and total flavones is its drug effect part.
Fructus Schisandrae Chinensis, Chinese medicine Schisandra chinensis derives from Magnoliaceae (Magnoliaceae), and Fructus Schisandrae Chinensis is famous Chinese medicine, its history in existing more than 2000 year of application, is recorded by China's pharmacopeia always.Fructus Schisandrae Chinensis begins to be loaded in Shennong's Herbal, is classified as top grade.Fructus Schisandrae Chinensis, property tart flavour temperature, return lung, the heart, kidney channel, have astringe the lung, nourishing kidney, antidiarrheal, arresting seminal emission, mind calming, the effect such as calm the nerves, be usually used in the symptoms such as treatment chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous sweating, Tianjin wound is thirsty, deficient pulse of losing heart, interior-heat are quenched one's thirst, palpitation and insomnia.Deoxyschizandrin is one of effective ingredient of Lignans in Schisandra chinensis.Principle active component in Fructus Schisandrae Chinensis is lignanoid, polysaccharide and volatile oil.Infectious hepatitis is had the effect significantly reducing glutamate pyruvate transaminase by Fructus Schisandrae Chinensis powder, and it is very fast to prove effective, and non-evident effect, application type is more.
Radix Puerariae, Radix Puerariae is the dry root of legume pueraria lobata, practises and claims Herba Gelsemii Elegantis.Autumn, season in winter two excavate, and take advantage of fresh-cut and become sheet or fritter, dry.Sweet in the mouth, pungent, cool in nature.There are expelling pathogenic factors from muscles for reducing heat, rash, promoting the production of body fluid to quench thirst, the merit of yang invigorating antidiarrheal.Being usually used in exterior syndrome heating, stiff nape and back, measles without adequate eruption, calentura is thirsty, and the deficiency of YIN is quenched one's thirst, diarrhea of heat type hematodiarrhoea, diarrhea due to hypofunction of the spleen.Containing multiple flavones ingredient, main active is Dai (daidzein), daidzin (daidzin), puerarin (puerarin), puerarin-7-xyloside (puerarin-7-xyloside) etc..Puerarin is the extract of Herba Gelsemii Elegantis, different name puerarin, and molecular formula is C21H20O9, molecular weight is 416.37, is white needle-like crystals in methanol acetic acid.Radix Puerariae total isoflavone has increase coronary artery blood flow and reduces myocardial oxygen consumption.
Semen Vitis viniferae, Semen Vitis viniferae is to separate products therefrom after Pericarpium Vitis viniferae, stem of Fructus Vitis viniferae after drying, and has energy height, price is low, have no side effect.The xerosis cutis that Semen Vitis viniferae energy antioxidation, desalination mottle, endocrine regulation imbalance cause, reduces melanin, skin whitening, functions of removing chloasma；Cell division and tissue regeneration can be stimulated, activate cells of superficial layer, reduce wrinkle, slow down aging；Can suppress and remove interior free yl, playing anticancer antianaphylactic effect；There is the effect of anti-prostate cancer, anti-liver neoplasm, it is also possible to resist neural damage.Semen Vitis viniferae extract has the good reputation of " skin vitamin " and " oral cosmetic product ", it is possible to protection collagen protein, improves skin elasticity and gloss, whitening, moisturizing, speckle dispelling；Reduce wrinkle, keep the soft and moist smooth of skin；Remove acne, healing cicatrix.First antioxidation be exactly grape seed extract OPC elite one of effect.Grape Seed Extract Procyanidin (OPC) is a kind of efficient free radical scavenger.The oxidative function of its free radical resisting is 50 times of vitamin E, ascorbic 20 times.Removing free radical poisonous in human body, protection human cell tissue is exempted from by the oxidative damage of free radical, it is prevented that the disease that the kinds more than 80 such as allergy, cancer, aging are relevant with free radical.Being based on the effect of this Semen Vitis viniferae, people from Europe claims Semen Vitis viniferae to be cosmetics in natural body, and it can recover activity of collagen, makes skin smooth and flexible.Semen Vitis viniferae or natural sunlight overcover, it is possible to stop ultraviolet damage skin.HDL-C and low density cholesterol ratio are to weigh a distinctive marks of human body cardiovascular health.Health association of the U.S. is thought: reduces cholesterol and improves the high density lipoprotein ratio to low density lipoprotein, LDL, being all the method for most important prevention cardiovascular disease.And Semen Vitis viniferae effect is that and can reduce low density cholesterol in blood, improving the level of HDL-C, both take into account simultaneously.In addition, Semen Vitis viniferae extract contains abundant vitamin E, and vitamin E is famous antioxidant, so the effect of Semen Vitis viniferae also includes preventing various disease, makes skin and muscle keep fit state simultaneously.Semen Vitis viniferae effect also has anti-prostate tumor and anti-liver neoplasm etc..
Herba Patriniae, cool in nature, acrid in the mouth, hardship；Heat-clearing and toxic substances removing, removing blood stasis and expelling pus；For appendicitis, dysentery, enteritis, hepatitis, eye conjunctivitis, postnatal blood stasis stomachache, carbuncle furuncle.There is hepatitis virus resisting, make hepatocyte inflammatory resolution and bile capillary dredging effect；There is promotion liver cell regeneration, it is prevented that hepatocellular degeneration, improve liver function effect.
Radix Notoginseng, sweet and slightly bitter taste, warm in nature；Enter liver, stomach, large intestine channel；Mainly there are hemostasis, dissipating blood stasis, detumescence, effect of analgesic therapy.To controlling haematemesis, hemoptysis, have blood in stool, metrorrhagia, puerperal blood faints, retention of lochia, fall symptoms such as flutterring blood stasis, traumatic hemorrhage, carbuncle pain and have good effect.Removing stasis to stop bleeding, analgesic therapy of invigorating blood circulation.Radix Notoginseng can be stopped blooding, again can dissipating blood stasis, have hemostasis and do not stay the stasis of blood, blood stasis dispelling and do not hinder feature just, be removing stasis to stop bleeding good medicine.Radix Notoginseng energy blood circulation promoting and blood stasis dispelling and subduing swelling and relieving pain, be the key medicine of analgesic therapy of invigorating blood circulation.Notoginseng extract except can blood circulation promoting and blood stasis dispelling, treat stable damage, additionally it is possible to promote bile secretion, there is the effect of anti-liver injury.
Radix Codonopsis, sweet in the mouth, property are flat, return spleen channel, lung meridian；There is invigorating the spleen and replenishing QI, effect of spleen invigorating lung benefiting.For deficiency of the spleen and lung, breathe hard, cardiopalmus, anorexia and loose stool, dyspnea due to deficiency cough, interior-heat is quenched one's thirst.Can enhancing human body immunity function, strengthen hemopoietic function, heart tonifying, shock, adjustment blood pressure, resist myocardial ischemia, improve hemorheology, acid mucopolysaccharide in Radix Codonopsis has anticoagulant, can reduce blood fat and reduces blood viscosity and plasma viscosity, the impact of cerebral thrombosis, myocardial infarction and ischemic heart desease there is obvious dependency, there is blood pressure lowering, blood fat reducing, antioxidation, defying age, improve the immunity of human body.Old myocardial infarction and cerebral thrombosis recovery phase are made moderate progress, has and purify the blood, prophylaxis of hypertension, the effect of cardiovascular and cerebrovascular disease.
The Radix Astragali, sweet in the mouth, warm in nature, return lung, spleen channel；Being apt to into taste, this product is mainly containing glycoside, polysaccharide, flavone, aminoacid, trace element etc..The renewal of organism metabolism, resisting fatigue, promotion serum and hepatic protein can be promoted；There is obvious diuresis, Jishengshenqiwan urine protein can be eliminated；Anemia animal phenomenon can be improved；Hypoglycemia can be raised, reduce hyperglycemia；Can excited breathe；Can strengthen and regulate body's immunity, interferon system being had facilitation, the premunition of body can be improved；The multiple viral institute such as infected by influenza cytopathogenic effect has slight inhibitory action, and influenza virus infected has protective effect；There is wide antibacterial action；The Radix Astragali, in cell is cultivated, can make cell number showed increased, and Growth of Cells is vigorous, life；Myocardial contraction can be strengthened, protect cardiovascular system, arrhythmia, coronary artery dilator and peripheral blood vessel, reduce blood pressure, platelet adhesion power can be reduced, reduce thrombosis；Also have blood fat reducing, defying age, anti-hypoxia, radioprotective, protect the liver etc. acts on.
Phosphoesterases complex, be from barley malt sprouts extract separate there is bioactive compound enzymic preparation, mainly include phosphodiesterase, phosphate, ribonuclease, deoxyribonuclease, nucleotidase, proteolytic enzyme, arginine esterase and amylase etc. more than ten and plant enzyme, for isabelline fine powder, water content, below 10%, is dissolved better in micro alkaline solution.Auxiliary therapeutical agent for chronic persistent hepatitis, chronic hepatitis, early stage liver cirrhosis etc..
Beneficial effects of the present invention
Component each in formula, through a large amount of screening tests, is screened by the health product of the present invention, the method adopting heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, bactericidal antiphlogistic, raising body immunity, and damaged liver is effectively repaired.Selected all components, Antrodia camphorata, propolis, Herba Patriniae, Radix Notoginseng, Radix Codonopsis can heat-clearing and toxic substances removing hepatoprotective dirty, liver is hemopoietic unit, antibacterial, the invasion of virus can reduce the work efficiency of liver, Radix Notoginseng, Radix Codonopsis has nourishing blood function, be can be directly against the enemy soldier, except hemopoietic, detoxication device maximum in liver or health, if attacking virus too much, liver can be unable to stand because workload is too big, this time can take Antrodia camphorata, propolis, Herba Patriniae, because Antrodia camphorata, propolis, Herba Patriniae has heat-clearing and toxic substances removing, effect of removing blood stasis and expelling pus, there is the effect promoting liver cell regeneration.Therefore above five kinds of Chinese medicine collaborative can heat-clearing and toxic substances removing hepatoprotective dirty.Fructus Schisandrae Chinensis, Radix Puerariae, Semen Hoveniae (Fructus Hoveniae), have and move back damp and hot effect, it is possible to regulates liver external environment condition, allows liver work more efficiently, and therefore Fructus Schisandrae Chinensis, Radix Puerariae, Semen Hoveniae (Fructus Hoveniae) can assist Antrodia camphorata, propolis, Herba Patriniae, Radix Notoginseng, Radix Codonopsis to reach the purpose of prevention of liver disease.Radix Notoginseng, Radix Codonopsis, the Radix Astragali, Semen Vitis viniferae, phosphoesterases complex can be healed the wounded and rescue the dying, and promote that hepatocyte recovers, repair injured cell, and Radix Codonopsis, the Radix Astragali also have the effect of QI invigorating.Antrodia camphorata, Radix Codonopsis, the Radix Astragali have the effect strengthening body immunity, it is possible to alleviate burden of liver, reach the purpose of prevention of liver disease.Propolis, Herba Patriniae, Radix Notoginseng have the effect that blood circulation promoting and blood stasis dispelling promotes other component to absorb.Additionally selected component Semen Vitis viniferae, can antioxidation, desalination mottle, activation cells of superficial layer, reduce wrinkle, slow down aging effect；Wherein Semen Vitis viniferae extract contains abundant vitamin E, and vitamin E is famous antioxidant, so the effect of Semen Vitis viniferae also includes preventing various disease, makes skin and muscle keep fit state simultaneously.
A kind of health product with liver repair function of the present invention, the method adopting heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, bactericidal antiphlogistic, raising body immunity, damaged liver is effectively repaired.All component synergism are good, can damaged liver effectively be repaired after using, and each effective ingredient draws is good, and bioavailability is high.Present invention process is simple, and raw material is easy to get, and is suitable for industrialized production.
Detailed description of the invention
According to following embodiment, it is possible to be more fully understood that the present invention.But, as it will be easily appreciated by one skilled in the art that the concrete material proportion described by embodiment, process conditions and result thereof be merely to illustrate the present invention and should without the present invention described in detail in restriction claims.
A kind of health product with liver repair function, component and the parts by weight of these health product include: Antrodia camphorata 20 parts, propolis 10 parts, Semen Hoveniae (Fructus Hoveniae) 25 parts, Fructus Schisandrae Chinensis 30 parts, Radix Puerariae 15 parts, Semen Vitis viniferae 25 parts, Herba Patriniae 15 parts, 20 parts of Radix Notoginseng, Radix Codonopsis 15 parts, the Radix Astragali 25 parts, phosphoesterases complex 20 parts, starch 30 parts.
The preparation method of a kind of health product with liver repair function, comprises the following steps:
1) getting the raw materials ready, get the raw materials ready according to described component and parts by weight, Antrodia camphorata pulverized 100 mesh sieves；
2) extraction of raw material of Chinese medicine pharmaceutically active ingredient, the water that parts by weight are raw material of Chinese medicine medicine parts by weight 10 times is added in Chinese medicine extracting tank, open stirring, raw material of Chinese medicine medicine Semen Hoveniae (Fructus Hoveniae), Fructus Schisandrae Chinensis, Radix Puerariae, Semen Vitis viniferae, Herba Patriniae, Radix Notoginseng, Radix Codonopsis, the Radix Astragali are added in Chinese medicine extracting tank, temperature of charge in Chinese medicine extracting tank is warming up to 85～90 DEG C, constant temperature extracts 1h, filters, and filtrate is standby；Adding in Chinese medicine extracting tank by the water that parts by weight are raw material of Chinese medicine medicine parts by weight 10 times, open stirring, added by filtering residue in Chinese medicine extracting tank, the temperature of charge in Chinese medicine extracting tank is warming up to 85～90 DEG C, constant temperature extracts 1h, filters, and filtrate is standby；Merge twice gained filtrate, vacuum be concentrated into former filtrate volume 1/5th the concentrated liquid of tradition Chinese medicine；The process conditions of vacuum concentration are: pressure is-0.07～-0.08Mpa, temperature is 45～50 DEG C；
3) granulate, by step 2) gained the concentrated liquid of tradition Chinese medicine, Antrodia camphorata, propolis, phosphoesterases complex, starch mix homogeneously, wet granulation, drying equipment used is fluid bed, process conditions are: temperature of charge is 40 DEG C～45 DEG C, inlet temperature is 65 DEG C～70 DEG C, and wind speed is 650rpm～700rpm, and air outlet temperature is 30 DEG C～35 DEG C；
4) granulate, by step 2) gained granule crosses 20 mesh sieve granulate；
5) dress capsule, by step 3) gained granule dress capsule, specification is 0.5g/ grain.
Using method: oral every day 2～3 times, each 2～4.
Detection method:
Total terpene assay method
Employing spectrophotometer method measures, and oleanolic acid is standard substance.
Accurately weigh the oleanolic acid standard substance 10.0mg of dry constant weight in the volumetric flask of 50mL, add methanol and dissolve, be diluted to scale, shake up, be the standard solution of concentration 0.2mg/mL.Take standard solution 0.4mL in 10mL tool plug rub oral examination tube, water bath method, add freshly prepared 5% vanillin of 0.2mL. glacial acetic acid solution and 0.8mL perchloric acid, 60 DEG C of reaction 20min, frozen water cools down, add 10mL glacial acetic acid, shake up, measure absorbance value at 550nm place with TU-1800SPC type ultraviolet-visible spectrophotometer.Calculate its content.
Determination of Total Flavonoids method
With rutin for standard solution, under 510nm, measure absorbance with TU-1800SPC type ultraviolet-uisible spectrophotometer, calculate the content of Flavonoids in extracting solution.
Procyanidin assay method
Taking health product dissolved in purified water, concentration is 1g/L, takes 0.5ml, puts in test tube, adds 4% vanillin methanol solution 3.0ml mixing, adds the dense HCl of 1.5ml, thoroughly mix immediately.Develop the color under room temperature about 15min, in 500nm assaying reaction liquid absorption value, does blank with 4% vanillin methanol solution.Notice that lucifuge operates.Below equation is adopted to calculate the amount of proanthocyanidin,
Procyanidin (× 10-3Mg)=A550nm÷ 0.55 × 100 × sample liquid extension rate
Deoxyschizandrin assay method
Adopting high-performance liquid chromatogram determination, mark product deoxyschizandrin (lot number 110764-200609) is purchased from National Institute for Food and Drugs Control, and purity more than 98%, for assay.Chromatographic condition: adopting AkzoNobel-KromasilC18 (250mm × 4.6mm, 5 μm) chromatographic column, mobile phase is acetonitrile (A)-water (B), gradient elution (0～30min, 51%A；30～60min, 51%A → 80%A；60～70min, 80%A → 51%A), flow velocity 1.0mL min-1, detects wavelength 217nm, column temperature 30 DEG C, sample size 10 μ L.According to calculated by peak area content.
Testing result is shown in embodiment 4.
Embodiment 2
A kind of health product with liver repair function, component and the parts by weight of these health product include: Antrodia camphorata 30 parts, propolis 20 parts, Semen Hoveniae (Fructus Hoveniae) 30 parts, Fructus Schisandrae Chinensis 35 parts, Radix Puerariae 20 parts, Semen Vitis viniferae 30 parts, Herba Patriniae 20 parts, 25 parts of Radix Notoginseng, Radix Codonopsis 20 parts, the Radix Astragali 30 parts, phosphoesterases complex 25 parts, starch 35 parts.
The preparation method of a kind of health product with liver repair function, comprises the following steps:
1) getting the raw materials ready, get the raw materials ready according to described component and parts by weight, Antrodia camphorata pulverized 100 mesh sieves；
2) extraction of raw material of Chinese medicine pharmaceutically active ingredient, the water that parts by weight are raw material of Chinese medicine medicine parts by weight 10 times is added in Chinese medicine extracting tank, open stirring, raw material of Chinese medicine medicine Semen Hoveniae (Fructus Hoveniae), Fructus Schisandrae Chinensis, Radix Puerariae, Semen Vitis viniferae, Herba Patriniae, Radix Notoginseng, Radix Codonopsis, the Radix Astragali are added in Chinese medicine extracting tank, temperature of charge in Chinese medicine extracting tank is warming up to 85～90 DEG C, constant temperature extracts 1h, filters, and filtrate is standby；Adding in Chinese medicine extracting tank by the water that parts by weight are raw material of Chinese medicine medicine parts by weight 10 times, open stirring, added by filtering residue in Chinese medicine extracting tank, the temperature of charge in Chinese medicine extracting tank is warming up to 85～90 DEG C, constant temperature extracts 1h, filters, and filtrate is standby；Merge twice gained filtrate, vacuum be concentrated into former filtrate volume 1/5th the concentrated liquid of tradition Chinese medicine；The process conditions of vacuum concentration are: pressure is-0.07～-0.08Mpa, temperature is 45～50 DEG C；
3) granulate, by step 2) gained the concentrated liquid of tradition Chinese medicine, Antrodia camphorata, propolis, phosphoesterases complex, starch mix homogeneously, wet granulation, drying equipment used is fluid bed, process conditions are: temperature of charge is 40 DEG C～45 DEG C, inlet temperature is 65 DEG C～70 DEG C, and wind speed is 650rpm～700rpm, and air outlet temperature is 30 DEG C～35 DEG C；
4) granulate, by step 2) gained granule crosses 30 mesh sieve granulate；
5) dress capsule, by step 3) gained granule dress capsule, specification is 0.8g/ grain.
Using method: oral every day 2～3 times, each 2～4.
The detection method of the present embodiment is with embodiment 1.
Testing result is shown in embodiment 4.
Embodiment 3
A kind of health product with liver repair function, component and the parts by weight of these health product include: Antrodia camphorata 25 parts, propolis 17 parts, Semen Hoveniae (Fructus Hoveniae) 29 parts, Fructus Schisandrae Chinensis 31 parts, Radix Puerariae 16 parts, Semen Vitis viniferae 28 parts, Herba Patriniae 17 parts, 23 parts of Radix Notoginseng, Radix Codonopsis 19 parts, the Radix Astragali 27 parts, phosphoesterases complex 24 parts, starch 32 parts.
The preparation method of a kind of health product with liver repair function, comprises the following steps:
1) getting the raw materials ready, get the raw materials ready according to described component and parts by weight, Antrodia camphorata pulverized 100 mesh sieves；
2) extraction of raw material of Chinese medicine pharmaceutically active ingredient, the water that parts by weight are raw material of Chinese medicine medicine parts by weight 10 times is added in Chinese medicine extracting tank, open stirring, raw material of Chinese medicine medicine Semen Hoveniae (Fructus Hoveniae), Fructus Schisandrae Chinensis, Radix Puerariae, Semen Vitis viniferae, Herba Patriniae, Radix Notoginseng, Radix Codonopsis, the Radix Astragali are added in Chinese medicine extracting tank, temperature of charge in Chinese medicine extracting tank is warming up to 85～90 DEG C, constant temperature extracts 1h, filters, and filtrate is standby；Adding in Chinese medicine extracting tank by the water that parts by weight are raw material of Chinese medicine medicine parts by weight 10 times, open stirring, added by filtering residue in Chinese medicine extracting tank, the temperature of charge in Chinese medicine extracting tank is warming up to 85～90 DEG C, constant temperature extracts 1h, filters, and filtrate is standby；Merge twice gained filtrate, vacuum be concentrated into former filtrate volume 1/5th the concentrated liquid of tradition Chinese medicine；The process conditions of vacuum concentration are: pressure is-0.07～-0.08Mpa, temperature is 45～50 DEG C；
3) granulate, by step 2) gained the concentrated liquid of tradition Chinese medicine, Antrodia camphorata, propolis, phosphoesterases complex, starch mix homogeneously, wet granulation, drying equipment used is fluid bed, process conditions are: temperature of charge is 40 DEG C～45 DEG C, inlet temperature is 65 DEG C～70 DEG C, and wind speed is 650rpm～700rpm, and air outlet temperature is 30 DEG C～35 DEG C；
4) granulate, by step 2) gained granule crosses 40 mesh sieve granulate；
5) dress capsule, by step 3) gained granule dress capsule, specification is 1g/ grain.
Using method: oral every day 2～3 times, each 2～4.
The detection method of the present embodiment is with embodiment 1.
Testing result is shown in embodiment 4.
Embodiment 4
Testing result
Conclusion: total terpene is effective ingredient contained by Antrodia camphorata, total flavones is effective ingredient contained by propolis, deoxyschizandrin is effective ingredient contained by Fructus Schisandrae Chinensis, procyanidin is effective ingredient contained by Semen Vitis viniferae, testing result proves that used by the present invention, effective ingredient can thoroughly be extracted by the extracting method of raw material of Chinese medicine pharmaceutically active ingredient, total terpene simultaneously, total flavones, deoxyschizandrin and procyanidin are respectively provided with the function that liver is repaired, therefore the health product of the present invention contain enough total terpenes, total flavones, deoxyschizandrin and procyanidin, so being a kind of health product effectively with liver repair function.
Embodiment 5
To CCl4The repair analysis of induced mice hepatic injury
Mice 20, is randomly divided into 2 groups, and first group is negative control group, and second group is test group, and each group all gives 0.2%CCl4After Oleum sesami 10ml/kg, 8h, first group of not medicine feed, second group of gastric infusion, specification is 10mg/kg, every day 3 times.7th day eye socket takes blood, surveys SGPT, and hepatic tissue makes PATHOMORPHOLOGICAL OBSERVATION OF PULLORUM.
SGPT (U/L) result:
Conclusion:
First group of mouse liver pathological changes problem is substantially free of solution, and second group can make impaired hepatic tissue recover to accelerate, and SGPT value reduces to be accelerated, and hepatic lesions degree reduces.Illustrate that the health product of the present invention have good liver repair function.
Embodiment described above is only that the preferred embodiment of the present invention is described; not the scope of the present invention is defined; under the premise designing spirit without departing from the present invention; various deformation that technical scheme is made by those of ordinary skill in the art and improvement, all should fall in the protection domain that claims of the present invention is determined.
Claims (6)
1. health product with liver repair function, it is characterized in that, component and the parts by weight of these health product include: Antrodia camphorata 20～30 parts, propolis 10～20 parts, Semen Hoveniae (Fructus Hoveniae) 25～30 parts, Fructus Schisandrae Chinensis 30～35 parts, Radix Puerariae 15～20 parts, Semen Vitis viniferae 25～30 parts, Herba Patriniae 15～20 parts, 20～25 parts of Radix Notoginseng, Radix Codonopsis 15～20 parts, the Radix Astragali 25～30 parts, phosphoesterases complex 10～15 parts, starch 20～25 parts.
2. a kind of health product with liver repair function according to claim 1, it is characterized in that, component and the parts by weight of these health product include: Antrodia camphorata 20 parts, propolis 10 parts, Semen Hoveniae (Fructus Hoveniae) 25 parts, Fructus Schisandrae Chinensis 30 parts, Radix Puerariae 15 parts, Semen Vitis viniferae 25 parts, Herba Patriniae 15 parts, 20 parts of Radix Notoginseng, Radix Codonopsis 15 parts, the Radix Astragali 25 parts, phosphoesterases complex 10 parts, starch 20 parts.
3. a kind of health product with liver repair function according to claim 1, it is characterized in that, component and the parts by weight of these health product include: Antrodia camphorata 30 parts, propolis 20 parts, Semen Hoveniae (Fructus Hoveniae) 30 parts, Fructus Schisandrae Chinensis 35 parts, Radix Puerariae 20 parts, Semen Vitis viniferae 30 parts, Herba Patriniae 20 parts, 25 parts of Radix Notoginseng, Radix Codonopsis 20 parts, the Radix Astragali 30 parts, phosphoesterases complex 15 parts, starch 25 parts.
4. a kind of health product with liver repair function according to claim 1, it is characterized in that, component and the parts by weight of these health product include: Antrodia camphorata 25 parts, propolis 17 parts, Semen Hoveniae (Fructus Hoveniae) 29 parts, Fructus Schisandrae Chinensis 31 parts, Radix Puerariae 16 parts, Semen Vitis viniferae 28 parts, Herba Patriniae 17 parts, 23 parts of Radix Notoginseng, Radix Codonopsis 19 parts, the Radix Astragali 27 parts, phosphoesterases complex 14 parts, starch 22 parts.
5. the preparation method of health product with liver repair function, it is characterised in that comprise the following steps:
1) getting the raw materials ready, component and parts by weight described in any one of Claims 1 to 4 are got the raw materials ready, and Antrodia camphorata pulverized 100 mesh sieves；
2) extraction of raw material of Chinese medicine pharmaceutically active ingredient, the water that parts by weight are raw material of Chinese medicine medicine parts by weight 10 times is added in Chinese medicine extracting tank, open stirring, raw material of Chinese medicine medicine Semen Hoveniae (Fructus Hoveniae), Fructus Schisandrae Chinensis, Radix Puerariae, Semen Vitis viniferae, Herba Patriniae, Radix Notoginseng, Radix Codonopsis, the Radix Astragali are added in Chinese medicine extracting tank, temperature of charge in Chinese medicine extracting tank is warming up to 85～90 DEG C, constant temperature extracts 1h, filters, and filtrate is standby；Adding in Chinese medicine extracting tank by the water that parts by weight are raw material of Chinese medicine medicine parts by weight 10 times, open stirring, added by filtering residue in Chinese medicine extracting tank, the temperature of charge in Chinese medicine extracting tank is warming up to 85～90 DEG C, constant temperature extracts 1h, filters, and filtrate is standby；Merge twice gained filtrate, vacuum be concentrated into former filtrate volume 1/5th the concentrated liquid of tradition Chinese medicine；
3) granulate, by step 2) gained the concentrated liquid of tradition Chinese medicine, Antrodia camphorata, propolis, phosphoesterases complex, starch mix homogeneously, wet granulation, drying equipment used is fluid bed, process conditions are: temperature of charge is 40 DEG C～45 DEG C, inlet temperature is 65 DEG C～70 DEG C, and wind speed is 650rpm～700rpm, and air outlet temperature is 30 DEG C～35 DEG C；
4) granulate, by step 2) gained granule crosses 20～40 mesh sieve granulate；
5) dress capsule, by step 3) gained granule dress capsule, specification is 0.5～1g/ grain.
6. the preparation method of a kind of health product with liver repair function according to claim 5, it is characterised in that described step 2) process conditions of vacuum concentration are: pressure is-0.07～-0.08Mpa, temperature is 45～50 DEG C.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101268833A (en) * | 2008-04-22 | 2008-09-24 | 杏林苑投资管理（北京）有限公司 | Health product having auxiliary protection and oxidation resistance function for chemical liver damnification |
| CN101601826A (en) * | 2008-06-11 | 2009-12-16 | 上海玉森新药开发有限公司 | A kind of Chinese medicine composition for the treatment of hepatitis B and preparation method thereof |
| CN102670763A (en) * | 2012-06-01 | 2012-09-19 | 广州市奥海生物科技有限公司 | Composition with auxiliary protection effect on chemical liver injury and preparation method of composition |
| CN104547013A (en) * | 2014-08-01 | 2015-04-29 | 陕西正晟康源生物医药有限公司 | Oral liquid for treating gastric mucosa and liver injury and preparation method of oral liquid |
| CN104906243A (en) * | 2015-05-25 | 2015-09-16 | 上海焦点生物技术有限公司 | Traditional Chinese medicine compound with liver protection function |
-
2016
- 2016-02-03 CN CN201610076062.XA patent/CN105707885A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101268833A (en) * | 2008-04-22 | 2008-09-24 | 杏林苑投资管理（北京）有限公司 | Health product having auxiliary protection and oxidation resistance function for chemical liver damnification |
| CN101601826A (en) * | 2008-06-11 | 2009-12-16 | 上海玉森新药开发有限公司 | A kind of Chinese medicine composition for the treatment of hepatitis B and preparation method thereof |
| CN102670763A (en) * | 2012-06-01 | 2012-09-19 | 广州市奥海生物科技有限公司 | Composition with auxiliary protection effect on chemical liver injury and preparation method of composition |
| CN104547013A (en) * | 2014-08-01 | 2015-04-29 | 陕西正晟康源生物医药有限公司 | Oral liquid for treating gastric mucosa and liver injury and preparation method of oral liquid |
| CN104906243A (en) * | 2015-05-25 | 2015-09-16 | 上海焦点生物技术有限公司 | Traditional Chinese medicine compound with liver protection function |
Non-Patent Citations (2)
| Title |
|---|
| 吴梧桐: "《酶类药物学》", 31 January 2011, 中药医药科技出版社 * |
| 董明慧等: "具有保肝作用的临床常用中药", 《中医药导报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107927257A (en) * | 2017-12-01 | 2018-04-20 | 贵州健瑞安药业有限公司 | A kind of health protection tea for preventing hepatic sclerosis and liver cancer and preparation method thereof |
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