CN105688196A - Chewable tablet for treating iron-deficiency anemia and preparation method thereof - Google Patents
Chewable tablet for treating iron-deficiency anemia and preparation method thereof Download PDFInfo
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- CN105688196A CN105688196A CN201610181006.2A CN201610181006A CN105688196A CN 105688196 A CN105688196 A CN 105688196A CN 201610181006 A CN201610181006 A CN 201610181006A CN 105688196 A CN105688196 A CN 105688196A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/40—Transferrins, e.g. lactoferrins, ovotransferrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/064—Saccharomycetales, e.g. baker's yeast
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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- Life Sciences & Earth Sciences (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention discloses a chewable tablet for treating iron-deficiency anemia and a preparation method thereof. The chewable tablet has the effects of efficiently and safely supplementing iron, enhancing human body immunity and removing helicobacter pylori. The chewable tablet takes bovine lactoferrin and yeast iron as main ingredients, and is prepared from the following ingredients in parts by weight: 1-10 parts of bovine lactoferrin, 1-20 parts of yeast iron, 1-15 parts of saccharose, 1-10 parts of potassium sorbate and 1-5 parts of a lubricating agent by means of dry tabletting or wet granulating and tabletting. The chewable tablet is prepared by organically combining bovine lactoferrin with yeast iron to reduce the production cost of lactoferrin products, and ensures better iron supplement effect by removing helicobacter pylori, so that organic uniformity of iron supplement effect, taste and cost can be realized.
Description
Technical field
The invention belongs to field of pharmaceutical technology, be specifically related to a kind of chewable tablet for the treatment of iron deficiency anemia prepared for raw material with Lac Bovis seu Bubali spy's albumen and yeast iron and preparation method thereof, iron deficiency anemia can be improved, remove helicobacter pylori。
Background technology
Ferrum is the trace element of needed by human, is the metabolic basis maintaining cell, synthesis participating in the duplication of DNA, the transmission of electronics, hemoglobin and various oxidoreductase etc. process。Iron deficiency anemia (IDA) refers to the internal storage iron deficiency that may be utilized in fabricating hemoglobin, hemoglobin synthesizes a kind of minicell, the hypochrosis that reduce and cause, it is modal a kind of anemia, higher with the women (particularly anemia of pregnant woman) of childbearing age and infant morbidity。Iron supplementary main on the market at present is divalent iron salt。Common medicine has ferrous sulfate, Ferrous gluconate, ferrous fumarate and ferrous succinate, and absorbance is relatively low, and the defect of stomach discomfort when many existence are taken。
Lactoferrin is except as a kind of food being of high nutritive value, also have antibacterial, antiviral, anticancer, regulate the several functions such as organism immune response, lactoferrin can with Multiple Classes of Antibiotics and antiviral drugs synergism, reduce drug dose, reduce antibiotic or disease-resistant fungi preparation to human liver, the infringement of renal function, simultaneously, strengthen the internal microorganism sensitivity to medicine, along with lactoferrin effect, function, the continuous expansion constantly illustrating and developing range of application of mechanism, lactoferrin is in treatment, nutritional supplementation, the aspects such as food have broad application prospects, because it has the effect removing helicobacter pylori, the iron deficiency anemia positive especially for helicobacter pylori has better effects, but its shortcoming is with high costs。
Yeast is a big amphimicrobian fungus of class, extensively parasitizes in each kind of plant。Research finds, yeast is a kind of ideal trace vector。At present, preliminary research has been done in the domestic effect to yeast enriched in metals ion, such as the yeast enrichment to gold, uranium, copper, zinc, ferrum, calcium etc.。In the process of culture yeasts add ferrum element, by yeast in growth course to the absorption of ferrum element and conversion, make ferrum protein in yeast body and polysaccharide organic be combined。Trophic structure and animal body that yeast is required in growth course are closely similar, meet animal body best nutritional proportioning。The yeast culture that this trace elements iron organically combines with yeast is exactly yeast iron。Yeast iron has good stability, absorbance is high, anti-interference and in food other composition coordinated good and with low cost。
But, how lactoferrin and yeast iron are organically combined and there is not yet correlational study。
Summary of the invention
In order to overcome the deficiencies in the prior art, make up the defect that existing ferrum supplementing preparation exists, the invention discloses a kind of chewable tablet treating iron deficiency anemia and preparation method thereof, also there is the effect increasing body immunity, removing helicobacter pylori while highly effective and safe iron supplement。
In order to realize foregoing invention purpose, the technical solution used in the present invention is as follows:
A kind of chewable tablet treating iron deficiency anemia, main component includes Bovine Lactoferrin and yeast iron。
Further, in parts by weight, including Bovine Lactoferrin 1 10 parts, yeast iron 1 20 parts, sucrose 1 15 parts, potassium sorbate 1 10 parts, lubricant 15 parts。
Described Bovine Lactoferrin is for purchasing finished product。
Described yeast iron is for purchasing finished product。
Described lubricant is selected from one or more in Pulvis Talci, sodium stearate, magnesium stearate, adipic acid, esters of silicon acis, phosphate ester。
The preparation method of the chewable tablet of above-mentioned treatment iron deficiency anemia, adopts compressing dry granulation or wet granule compression tablet to prepare。
The present invention, by both lactoferrin and yeast iron being organically combined, reduces the production cost of lactoferrin product, ensure that better iron supplement effect by removing helicobacter pylori, it is achieved that the organic unity of iron supplement effect, mouthfeel and cost。Its beneficial effect is mainly manifested in the following aspects: 1, adopting milk protein ferrum and yeast iron as main supplements-iron, absorption rate is high, and does not have the side effect of now common ferrum supplementing preparation, has good efficacy for preventing and treating iron deficiency anemia；2, the Bovine Lactoferrin that the present invention adds there is antibacterial, antiviral, anticancer and regulate the several functions such as organism immune response, lactoferrin can with Multiple Classes of Antibiotics and antiviral drugs synergism, reduce drug dose, reduce antibiotic or the infringement to human body Liver and kidney function of the disease-resistant fungi preparation, strengthen the internal microorganism sensitivity to medicine simultaneously, also have obvious curative effect for removing helicobacter pylori；3, the compositions of the present invention utilizes natural food materials to make, and as a kind of food therapeutic health long-term taking, human body can will not produce harmful effect, and meet the Vehicles Collected from Market trend to pure natural health-care product and medicine, therefore have good market prospect。
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention made further explanation explanation。
Embodiment 1
A kind of chewable tablet treating iron deficiency anemia, is made up of the material of following parts by weight: include Bovine Lactoferrin 2 parts, yeast iron 18 parts, sucrose 5 parts, potassium sorbate 3 parts, lubricant 2 parts, adopting compressing dry granulation or wet granule compression tablet to make chewable tablet, every 2g, for finished product。
Embodiment 2
A kind of chewable tablet treating iron deficiency anemia, is made up of the material of following parts by weight: include Bovine Lactoferrin 4 parts, yeast iron 16 parts, sucrose 4 parts, potassium sorbate 3 parts, lubricant 3 parts, adopting compressing dry granulation or wet granule compression tablet to make chewable tablet, every 2g, for finished product。
Embodiment 3
A kind of chewable tablet treating iron deficiency anemia, is made up of the material of following parts by weight: include Bovine Lactoferrin 6 parts, yeast iron 14 parts, sucrose 4 parts, potassium sorbate 3 parts, lubricant 3 parts, adopting compressing dry granulation or wet granule compression tablet to make chewable tablet, every 2g, for finished product。
Embodiment 4
A kind of chewable tablet treating iron deficiency anemia, is made up of the material of following parts by weight: include Bovine Lactoferrin 8 parts, yeast iron 14 parts, sucrose 4 parts, potassium sorbate 2 parts, lubricant 2 parts, adopting compressing dry granulation or wet granule compression tablet to make chewable tablet, every 2g, for finished product。
Embodiment 5
The chewable tablet for the treatment of iron deficiency anemia of the present invention is for treating the experiment of common Anemic patients。
Select 80 example Anemic patients in old age, it is divided into treatment group (40 example) and matched group (40 example), treatment group adopts the chewable tablet treatment of the embodiment of the present invention 4 preparation, take 2 every day, each taking 6g, matched group adopts the yeast iron preparation with dosage, takes 2 every day, cycle is one month, and drug withdrawal detected blood hemoglobin concentration after 1 month。
Common Anemic patients's Experiment on therapy result is as follows: treatment group and matched group hemoglobin concentration respectively 125g/L and 97g/L, treatment group curative effect is better than matched group, it was demonstrated that this chewable tablet can be effectively improved anemia。
Embodiment 6
The chewable tablet for the treatment of iron deficiency anemia of the present invention is for treating the experiment of helicobacter pylori positive anemia patient。
Select 80 example Helicobacter pylori Anemic patients, it is divided into treatment group (40 example) and matched group (40 example), treatment group adopts the chewable tablet treatment of the embodiment of the present invention 4 preparation, take 2 every day, each taking 6g, matched group adopts the common yeast iron preparation with dosage, takes 2 every day, cycle is one month, and drug withdrawal detected helicobacter pylori eradication situation and blood hemoglobin concentration after 1 month。
Patient treatment experimental result is as follows: treatment group and matched group are to the eradication rate of helicobacter pylori respectively 92.5% and 25%, hemoglobin concentration is 141g/L and 113g/L respectively, treatment group curative effect is better than matched group, prove that this chewable tablet can effectively eradicate the helicobacter pylori of patient, improve Status of Anemia。
Although having been described for the specific embodiment of the present invention above, various change without departing from scope of the claims it is apparent that can make。It is to say, the technical spirit of the foundation present invention is to any simple modification made for any of the above embodiments, equivalent variations and modification, belong in the scope of technical solution of the present invention。
Claims (6)
1. the chewable tablet treating iron deficiency anemia, it is characterised in that main component includes Bovine Lactoferrin and yeast iron。
2. a kind of chewable tablet treating iron deficiency anemia according to claim 1, it is characterised in that in parts by weight, including Bovine Lactoferrin 1 10 parts, yeast iron 1 20 parts, sucrose 1 15 parts, potassium sorbate 1 10 parts, lubricant 15 parts。
3. a kind of chewable tablet treating iron deficiency anemia according to claim 2, it is characterised in that described Bovine Lactoferrin is for purchasing finished product。
4. a kind of chewable tablet treating iron deficiency anemia according to claim 2, it is characterised in that described yeast iron is for purchasing finished product。
5. a kind of chewable tablet treating iron deficiency anemia according to claim 2, it is characterised in that described lubricant is selected from one or more in Pulvis Talci, sodium stearate, magnesium stearate, adipic acid, esters of silicon acis, phosphate ester。
6. the preparation method according to a kind of chewable tablet treating iron deficiency anemia according to any one of claim 1-5, it is characterised in that adopt compressing dry granulation or wet granule compression tablet to prepare。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610181006.2A CN105688196A (en) | 2016-03-28 | 2016-03-28 | Chewable tablet for treating iron-deficiency anemia and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610181006.2A CN105688196A (en) | 2016-03-28 | 2016-03-28 | Chewable tablet for treating iron-deficiency anemia and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105688196A true CN105688196A (en) | 2016-06-22 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610181006.2A Pending CN105688196A (en) | 2016-03-28 | 2016-03-28 | Chewable tablet for treating iron-deficiency anemia and preparation method thereof |
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| CN (1) | CN105688196A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT201700002411A1 (en) * | 2017-01-11 | 2018-07-11 | Bmg Pharma S R L | PHARMACEUTICAL PREPARATION FOR THE TREATMENT OF HYPOFERREMIA AND SIDEROPENIC ANEMIA |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1689643A (en) * | 2004-04-27 | 2005-11-02 | 浙江可立思安制药有限公司 | Lactoferrin chewing tablet and preparation method thereof |
| CN101803695A (en) * | 2010-04-26 | 2010-08-18 | 北京东方红航天食品饮料有限公司 | Calcium and iron supplement product being applicable to children |
-
2016
- 2016-03-28 CN CN201610181006.2A patent/CN105688196A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1689643A (en) * | 2004-04-27 | 2005-11-02 | 浙江可立思安制药有限公司 | Lactoferrin chewing tablet and preparation method thereof |
| CN101803695A (en) * | 2010-04-26 | 2010-08-18 | 北京东方红航天食品饮料有限公司 | Calcium and iron supplement product being applicable to children |
Non-Patent Citations (1)
| Title |
|---|
| 柳启沛等: "高铁食用酵母铁资源生物利用率评价 II.婴幼儿喂养试验", 《营养学报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT201700002411A1 (en) * | 2017-01-11 | 2018-07-11 | Bmg Pharma S R L | PHARMACEUTICAL PREPARATION FOR THE TREATMENT OF HYPOFERREMIA AND SIDEROPENIC ANEMIA |
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| SE01 | Entry into force of request for substantive examination | ||
| CB03 | Change of inventor or designer information |
Inventor after: Wang Jingsu Inventor after: Wang Shengzhou Inventor after: Qian Yuan Inventor before: Wang Jing Inventor before: Wang Shengzhou Inventor before: Qian Yuan |
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| COR | Change of bibliographic data | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160622 |
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| RJ01 | Rejection of invention patent application after publication |