CN105687900A - 一种治疗强直性脊柱炎的中药组合物及制备 - Google Patents

一种治疗强直性脊柱炎的中药组合物及制备 Download PDF

Info

Publication number
CN105687900A
CN105687900A CN201610117750.6A CN201610117750A CN105687900A CN 105687900 A CN105687900 A CN 105687900A CN 201610117750 A CN201610117750 A CN 201610117750A CN 105687900 A CN105687900 A CN 105687900A
Authority
CN
China
Prior art keywords
parts
herba
chinese medicine
rhizoma
medicine composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201610117750.6A
Other languages
English (en)
Inventor
毕建飞
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201610117750.6A priority Critical patent/CN105687900A/zh
Publication of CN105687900A publication Critical patent/CN105687900A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/237—Notopterygium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A61K35/644—Beeswax; Propolis; Royal jelly; Honey
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282—Artemisia, e.g. wormwood or sagebrush
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A61K36/746—Morinda
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8994—Coix (Job's tears)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Insects & Arthropods (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

本发明涉及一种治疗强直性脊柱炎的中药组合物及制备，其特征是中药的原料药份数如下：羌活6～9份、豨莶草4～6份、槲寄生4～6份、千年健6～8份、凤仙透骨草4～6份、巴戟天2～4份、文冠果6～9份、北刘寄奴4～6份、竹节参6～9份、血竭4～6份、没药6～9份、薏苡仁8～12份、泽兰4～6份、蜂胶6～10份、甘草6～9份。本发明的有益效果是：祛风祛湿、祛瘀止痛、补益肝肾、调节免疫，祛除酸、麻、痛、胀、僵，达到提高生活质量，脊柱康复的目的。副作用少。疗效高。

Description

一种治疗强直性脊柱炎的中药组合物及制备
技术领域
本发明涉及一种治疗强直性脊柱炎的中药组合物及制备。
众所周知，强直性脊柱炎(AS)是以骶髂关节和脊柱附着点炎症为主要症状的疾病。与HLA-B27呈强关联。某些微生物(如克雷白杆菌)与易感者自身组织具有共同抗原，可引发异常免疫应答。使四肢大关节，以及椎间盘纤维环及其附近结缔组织纤维化和骨化，以及关节强直为病变特点的慢性炎性疾病。强直性脊柱炎属风湿病范畴，是血清阴性脊柱关节病的一种。该病病因尚不明确，是以脊柱为主要病变部位的慢性病，累及骶髂关节，引起脊柱强直和纤维化，造成不同程度眼、肺、肌肉、骨骼病变，属自身免疫性疾病。对于16～25岁青年，尤其是青年男性。强直性脊柱炎一般起病比较隐匿，早期可无任何临床症状，有些病人在早期可表现出轻度的全身症状，如乏力、消瘦、长期或间断低热、厌食、轻度贫血等。由于病情较轻，病人大多不能早期发现，致使病情延误，失去最佳治疗时机。目前治疗常采用非甾体类抗炎药、甲氨蝶呤、激素治疗，其副作用大，给患者的心身带来不适。
发明内容
本发明中药的有益效果是：祛风祛湿、祛瘀止痛、补益肝肾、调节免疫，祛除酸、麻、痛、胀、僵，达到提高生活质量，脊柱康复的目的。临床上常根据不同症型辨证施治。
本发明所要解决的技术问题是为了克服技术上的不足，提供一种疗效好、疗程短，缓解率高，成本低，无毒副作用的一种治疗强直性脊柱炎的中药组合物及制备。
为了上述目的，一种治疗强直性脊柱炎的中药组合物，其特征是中药的原料药份数如下：羌活6～9份、豨莶草4～6份、槲寄生4～6份、千年健6～8份、凤仙透骨草4～6份、巴戟天2～4份、文冠果6～9份、北刘寄奴4～6份、竹节参6～9份、血竭4～6份、没药6～9份、薏苡仁8～12份、泽兰4～6份、蜂胶6～10份、甘草6～9份。
制备方法：先将巴戟天加水蒸馏收集蒸馏液备用；将薏苡仁煮熟调成糊备用；再将羌活、豨莶草、槲寄生、千年健、凤仙透骨草、北刘寄奴、文冠果、血竭、没药、泽兰、没药、甘草加入7倍65％乙醇溶液多功能提取罐中加热回流1小时，回收乙醇至尽，滤液滤过备用；将上述残渣加竹节参水煎2小时，取滤液加上述蒸馏液、薏苡仁糊搅拌均匀，浓缩至相对密度为1.15-1.25((50℃)膏剂，即得。
本发明中药功效：羌活味辛、苦，性温。归膀胱、肾经。功效：解表散寒，祛风除湿，止痛。用于头痛项强，风湿痹痛，肩背酸痛。豨莶草味辛、苦，性寒。归肝、肾经。功效：祛风湿，利关节，解毒。用于风湿痹痛，筋骨无力，腰膝酸软，四肢麻痹，半身不遂，风疹湿疮。槲寄生味苦，性平。归肝、肾经。功效：祛风湿，补肝肾，强筋骨，安胎元。用于风湿痹痛，腰膝酸软，筋骨无力，崩漏经多，妊娠漏血，胎动不安，头晕目眩。千年健苦、辛，温。归肝、肾经。功效：祛风湿，壮筋骨。用于风寒湿痹，腰膝冷痛，拘挛麻木，筋骨痿软。凤仙透骨草苦、辛，平；有小毒。归肝、肾经。祛风除湿，活血止痛。用于风湿痹痛，跌打伤痛。巴戟天味甘、辛，性微温。归肾、肝经。功效：补肾阳，强筋骨，祛风湿。用于阳痿遗精，宫冷不孕，月经不调，少腹冷痛，风湿痹痛，筋骨痿软。文冠果味甘、微苦，性凉。归肝、肾经。祛风除湿，消肿止痛，收湿敛疮。用于风湿痹痛，关节肿胀，屈伸不利，皮肤湿疮。北刘寄奴味苦，性寒。归脾、胃、肝、胆经。功效：活血祛瘀，通经止痛，凉血，止血，清热利湿。用于跌打损伤，外伤出血，瘀血经闭，月经不调，产后瘀痛，癥瘕积聚，血痢，血淋，湿热黄疸，水肿腹胀。竹节参味甘、微苦，性温。归肝、脾、肺经。功效：散瘀止血，消肿止痛，祛痰止咳，补虚强壮。用于痨嗽咯血，跌扑损伤，咳嗽痰多，病后虚弱。血竭味甘、咸，性平。归心、肝经。功效：活血定痛，化瘀止血，生肌敛疮。用于跌打损伤，心腹瘀痛，外伤出血，疮疡不敛。没药味辛、苦，性平。归心、肝、脾经。功效：散瘀定痛，消肿生肌。用于胸痹心痛，胃脘疼痛，痛经经闭，产后瘀阻，癥瘕腹痛，风湿痹痛，跌打损伤，痈肿疮疡。苏木味甘、咸，性平。归心、肝、脾经。功效：活血祛瘀，消肿止痛。用于跌打损伤，骨折筋伤，瘀滞肿痛，经闭痛经，产后瘀阻，胸腹刺痛，痈疽肿痛。薏苡仁味甘、淡，性凉。归脾、胃、肺经。功效：利水渗湿，健脾止泻，除痹，排脓，解毒散结。用于水肿，脚气，小便不利，脾虚泄泻，湿痹拘挛，肺痈，肠痈，赘疣，癌肿。泽兰味苦、辛，性微温。归肝、脾经。功效：活血调经，祛瘀消痈，利水消肿。用于月经不调，经闭，痛经，产后瘀血腹痛，疮痈肿毒，水肿腹水。蜂胶苦、辛，寒。归脾、胃经。抗菌消炎、调节免疫、抗氧化、加速组织愈合。用于高脂血症和糖尿病的辅助治疗。甘草味甘，性平。归心、肺、脾、胃经。功能主治：补脾益气，清热解毒，祛痰止咳，缓急止痛，调和诸药。以上药物配伍、相得益彰。
本发明遵循中医的处方原则，水煎服用，经多年临床应用验证，有效率95％以上，治愈率85％以上，无毒副作用。
具体实施方式
下面结合实施例对本发明作进一步描述：
实施例1：一种治疗强直性脊柱炎的中药组合物及制法，其特征是中药的原料药份数如下：羌活6～9份、豨莶草4～6份、槲寄生4～6份、千年健6～8份、凤仙透骨草4～6份、巴戟天2～4份、文冠果6～9份、北刘寄奴4～6份、竹节参6～9份、血竭4～6份、没药6～9份、薏苡仁8～12份、泽兰4～6份、蜂胶6～10份、甘草6～9份。制备同上述膏剂，即得。
实施例2：一种治疗强直性脊柱炎的中药组合物，其特征是中药的原料药份数如下：羌活g份、豨莶草6份、槲寄生4份、千年健6份、凤仙透骨草6份、巴戟天2份、文冠果6份、北刘寄奴6份、竹节参9份、血竭4份、没药9份、薏苡仁12份、泽兰4份、蜂胶6份、甘草9份。制备同实施例1即得膏剂，分装每份10g。
临床疗效总结：
一、一般资料：本发明多年来在临床应用广泛，治疗患者52例，其中男41例，女11例，年龄在16-25岁之间，平均21.2岁。病程在1-12天，平均7.8天.疗效频佳。
二、诊断标准：临床表现；(1)腰和(或)脊柱、腹股沟、臀部或下肢酸痛不适，或不对称性外周寡关节炎、尤其是下肢寡关节炎，症状持续≥6周。
(2)夜间痛或晨僵明显。(3)活动后缓解。(4)足跟痛或其他肌腱附着点病。(5)虹膜睫状体炎现在症或既往史。(6)AS家族史或HLA-B27阳性。(7)非甾体抗炎药(NSAIDs)能迅速缓解症状。2.影像学或病理学：(1)双侧X线骶髂关节炎≥III期。(2)双侧CT骶髂关节炎≥II期。(3)CT骶髂关节炎不足II级者，可行MRI检查。如表现软骨破坏、关节旁水肿和(或)广泛脂肪沉积，尤其动态增强检查关节或关节旁增强强度＞20％，且增强斜率＞10％/min者。(4)骶髂关节病理学检查显示炎症者。3.诊断：符合临床标准第1项及其他各项中之3项，以及影像学、病理学标准之任何一项者，可诊断AS。
三、服药方法：成人每日早、晚2次内服，每次10g，10日为1疗程。
四、疗效判断标准
治愈：临床症状完全消失。
好转：临床症状改善。
无效：临床症状无变化或加重。
五、治疗效果：本发明多年来在临床应用，治疗患者52例，治愈42例占80.78％；好转8例占15.38％；未愈2例占3.84％。总有效率为96.16％。
六、典型病例
1、丛XX，男，22岁，2012年8月就诊。主诉腰背部不适，清晨时僵硬，活动症状有改善1个月，加重3天，在当地卫生院经用双氯酚酸钾口服1周效果不佳。影像学检查：X光片有骶髂关节炎征象，即证实为脊柱病。患者要求服本发明中药2疗程，临床症状完全消失，半年后随访未再复发。
2、宋XX，男，16岁，2013年10月就诊，主诉腰背部不适，清晨时僵硬伴下肢痛不适2周，加重1天，在当地卫生院点滴头孢霉素、吃消炎痛片1周效果不佳，影像学检查提示：强直性脊柱炎。患者要求服本发明中药3疗程，临床症状完全消失，至今未复发。
3、李X，男，21岁，2014年6月就诊。患者腰背部不适，清晨时僵硬，活动症状改善，伴全身乏力，给予布洛芬口服病情反复发作，影像学检查提示：强直性脊柱炎。患者要求服本发明中药3疗程，临床症状完全消失，随访未再复发。

Claims (2)

1.一种治疗强直性脊柱炎的中药组合物，其特征是中药的原料药份数如下：羌活6～9份、豨莶草4～6份、槲寄生4～6份、千年健6～8份、凤仙透骨草4～6份、巴戟天2～4份、文冠果6～9份、北刘寄奴4～6份、竹节参6～9份、血竭4～6份、没药6～9份、薏苡仁8～12份、泽兰4～6份、蜂胶6～10份、甘草6～9份。
2.根据权利要求1一种治疗强直性脊柱炎的中药组合物的制备方法，其特征是先将巴戟天加水蒸馏收集蒸馏液备用；将薏苡仁煮熟调成糊备用；再将羌活、豨莶草、槲寄生、千年健、凤仙透骨草、北刘寄奴、文冠果、血竭、没药、泽兰、没药、甘草加入7倍65％乙醇溶液多功能提取罐中加热回流1小时，回收乙醇至尽，滤液滤过备用；将上述残渣加竹节参水煎2小时，取滤液加上述蒸馏液、薏苡仁糊搅拌均匀，浓缩至相对密度为1.15-1.25((50℃)膏剂，即得。
CN201610117750.6A 2016-02-26 2016-02-26 一种治疗强直性脊柱炎的中药组合物及制备 Pending CN105687900A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610117750.6A CN105687900A (zh) 2016-02-26 2016-02-26 一种治疗强直性脊柱炎的中药组合物及制备

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610117750.6A CN105687900A (zh) 2016-02-26 2016-02-26 一种治疗强直性脊柱炎的中药组合物及制备

Publications (1)

Publication Number Publication Date
CN105687900A true CN105687900A (zh) 2016-06-22

Family

ID=56222748

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610117750.6A Pending CN105687900A (zh) 2016-02-26 2016-02-26 一种治疗强直性脊柱炎的中药组合物及制备

Country Status (1)

Country Link
CN (1) CN105687900A (zh)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101085327A (zh) * 2007-06-12 2007-12-12 王敏 一种中药透皮液

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101085327A (zh) * 2007-06-12 2007-12-12 王敏 一种中药透皮液

Similar Documents

Publication Publication Date Title
CN103156972B (zh) 一种治疗骨折、骨裂和跌打损伤的中药组合物
CN104491676A (zh) 平瘿散结汤
CN103735927B (zh) 一种治疗痛风急性期的中药组合物及其制备方法
CN107854683A (zh) 一种治疗湿热痹阻型膝骨关节炎的膏药
CN102670914B (zh) 治疗慢性胃肠炎柴胡中药口服液及制备方法
CN104667035A (zh) 一种治疗痛风的药物
CN104689132A (zh) 一种治疗银屑病的中药组合物
CN104984313B (zh) 一种治疗冻疮的中药药酒
CN113332407A (zh) 一种驱寒排湿活血通络的外用敷剂
CN107998235B (zh) 治疗踝关节扭伤的复方壮药物及其制备方法
CN105311210A (zh) 治疗风湿骨病的药物组合物
CN104324285A (zh) 一种治疗痛风的中药制剂
CN105687900A (zh) 一种治疗强直性脊柱炎的中药组合物及制备
CN104116983A (zh) 一种预防月子病的口服液
CN103933299A (zh) 治疗风湿性关节炎的中药制剂
CN102861195B (zh) 一种治疗风湿疼痛的药物组合物
CN102688401B (zh) 治疗慢性肝炎茅根中药口服液及制备方法
CN102028916B (zh) 用于治疗腰腿痛的鸡骨威灵香汤
CN106728060A (zh) 一种治疗风湿病的外用膏药及其制备方法
CN101884714B (zh) 一种治疗荨麻疹的中药汤剂
CN104083706A (zh) 一种治疗胃炎的蒲公英中药汤剂及其制备方法
CN116196359A (zh) 一种治疗风湿跌打通脉中药酒及其制备方法
CN104688916A (zh) 一种治疗银屑病的中药组合物
CN114652797A (zh) 用于骨折患者养血补气的中药配方及其中药液的制备方法
CN113499372A (zh) 一种中药止痛贴

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20160622

WD01 Invention patent application deemed withdrawn after publication