CN105687875A - Traditional Chinese medicine composition for preventing and treating delayed emesis caused by chemotherapy - Google Patents

Traditional Chinese medicine composition for preventing and treating delayed emesis caused by chemotherapy Download PDF

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CN105687875A
CN105687875A CN201610181325.3A CN201610181325A CN105687875A CN 105687875 A CN105687875 A CN 105687875A CN 201610181325 A CN201610181325 A CN 201610181325A CN 105687875 A CN105687875 A CN 105687875A
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chinese medicine
medicine composition
delayed emesis
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李红艳
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A—HUMAN NECESSITIES
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02—Algae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches

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Abstract

The invention discloses a traditional Chinese medicine composition for preventing and treating delayed emesis caused by chemotherapy. The composition is prepared from the following medicinal raw materials: caragana rosea, elaeagnus angustifolia, semen podocarpi macrophylli, cassiope selaginoides hook, root of melodinus hemsleyanus, rice polishings, citrus aurantium, memorialis hirta, coprinopsisatramentaria and trumpet shells. The traditional Chinese medicine composition can be used for overcoming the defect of western medicines in treating delayed emesis caused by chemotherapy, is exact in curative effect and convenient to take, does not have side effect, and guarantees smooth performance of chemotherapy.

Description

A kind of chemotherapy of preventing and treating causes the Chinese medicine composition of delayed emesis
Technical field
The present invention relates to Chinese medicine sciemtifec and technical sphere, cause the Chinese medicine composition of delayed emesis particularly to a kind of chemotherapy of preventing and treating。
Background technology
Delayed emesis occurs after chemotherapy starts 24 hours, and in 48～72 hours, substantially, sustainable 5～7 days, degree can be lighter than acute vomiting in performance。Modern medicine is thought, chemotherapy cause vomiting mainly through following three approach: one be chemotherapeutic stimulating gastrointestinal road especially from stomach to ileum pheochromocyte release 5-HT, with-HT3Receptor combines generation neural impulse and is caused vomiting by the incoming vomiting center of neurotransmitter；Two is that anticarcinogen and metabolite thereof stimulate the CTZ (the emetic district of chemoreceptor) being positioned at back zone, ventriculus quartus to cause vomiting；Article 3 approach be sensation, spirit the factor stimulate cerebral cortex path cause vomiting。But, the final common path of vomiting is not also confirmed completely at present, does not still have a kind of medicine can provide in the different chemotherapy stages and protects completely, 5-HT3Receptor blocking agent such as ondansetron, granisetron, holder wash the treatment acute vomiting curative effects such as department's fine jade better, and the effect of delayed emesis is undesirable。After many Chemotherapy in Patients stop, still there is inappetence, nausea and vomiting in a period of time, directly affects patient's body constitution and recovers and the proceeding of chemotherapy。Chinese medicine has the advantage of Mutiple Targets treatment in this respect, and the present inventor sums up clinical experience for many years, develops a kind of chemotherapy of preventing and treating and causes the Chinese medicine composition of delayed emesis。
Summary of the invention
It is an object of the invention to overcome above-mentioned deficiency existing in prior art, namely provide a kind of chemotherapy of preventing and treating to cause the Chinese medicine composition of delayed emesis。
In order to realize foregoing invention purpose, the invention provides techniques below scheme:
A kind of chemotherapy of preventing and treating causes the Chinese medicine composition of delayed emesis, is made up of the crude drug of following mass ratio:
Radix Caraganae Roseae 20-30 part, Fructus Elaeagni Angustifoliae 25-35 part, Semen Podocarpi Macrophylli 10-20 part, Herba Cassiopes selaginoidis 15-25 part, river Fructus Melodini Suaveolentis root 15-25 part, Testa oryzae 10-20 part, Citrus aurantium L. var. amara Engl. 2-4 part, Herba Gonostegiae hirtae 20-30 part, Coprinus atramentarius (Bull.) Fr. (Coprinus sterquilinus Fr.) 3-9 part, Concha rapanae thomasianae 20-30 part。
The pharmacological action of raw material of Chinese medicine medicine of the present invention is as follows:
Radix Caraganae Roseae: sweet, micro-pungent, flat。Spleen invigorating, kidney tonifying, stimulate the menstrual flow, diuresis。Curing mainly deficient consumptive fever, cough with asthma, stranguria with turbid discharge, sexual impotence, metrorrhagia, leucorrhea, breast is few, uterine prolapse。
Fructus Elaeagni Angustifoliae: sour, micro-sweet, cool。Liver-nourishing kidney-boosting, spleen invigorating regulating menstruation。Cure mainly deficiency of the liver dizzy, lumbago due to renal deficiency, insufficiency of the spleen diarrhoea, dyspepsia, leukorrhagia, menoxenia。
Semen Podocarpi Macrophylli: sweet, tepor。Promoting the circulation of QI to relieve pain, nourish blood。Cure mainly gastralgia, blood deficiency shallow complexion。
Herba Cassiopes selaginoidis: hardship pungent, micro-, flat。Circulation of qi promoting, invigorates blood circulation, and pain relieving is calmed the nerves。Cure mainly stagnation of liver-QI and stomach-QI, coerce rib abdominal distention, rheumatic arthralgia, traumatic injury, insomnia。
River Fructus Melodini Suaveolentis root: enrich blood, heat clearing away。Controlling weakness of the spleen and stomach, dyspepsia, blood deficiency breast is few, aphtha of the mouth and tongue and gingiva pain etc.。
Testa oryzae: sweet, flat, returns stomach, large intestine channel。Appetizing, the therapeutic method to keep the adverse QI flowing downwards, removing food stagnancy。Cure mainly the cancer of the esophagus, regurgitation, beriberi。
Citrus aurantium L. var. amara Engl.: hardship pungent, sweet, micro-, flat。Regulate the flow of vital energy the chest stuffiness relieving, stomach function regulating preventing or arresting vomiting。Cure mainly painful abdominal mass in the heart vexed, abdominal distention, anorexia, nausea and vomiting。
Herba Gonostegiae hirtae: hardship sweet, micro-, cool。Heat-clearing and toxic substances removing, spleen invigorating removing food stagnancy, inducing diuresis and reducing edema, dissipating blood stasis stops blooding。Cure mainly acute mastitis, toxic swelling, dysentery, dyspepsia, abdominal pain due to retention of food, infantile malnutrition, leukorrhagia, edema, dysuria, dysmenorrhea, traumatic injury, hemoptysis, spit blood, traumatic hemorrhage。
Coprinus atramentarius (Bull.) Fr. (Coprinus sterquilinus Fr.): sweet, flat, mild toxicity。Benefit the intestines and stomach, phlegm-eliminiating and qi-regulating, removing toxic substances and promoting subsidence of swelling。Curing mainly inappetence, cough is spat, and children's's epilepsy is sick, stagnation of QI distending pain, and furuncle swells skin infection。
Concha rapanae thomasianae: salty, cold。Spasmolytic, antacid, dissipating phlegm and resolving masses。Cure mainly gastric and duodenal ulcers, neurasthenia, spasm of the limbs, chronic osteomyelitis, tuberculous lymphadenitis。
Chinese medicine is thought, chemotherapy causes delayed emesis, and it is in the nature body void, it is designated as vomiting, and " righting preventing or arresting vomiting " is the fundamentum for the treatment of, and impose according to patient's body constitution, tumor character, chemotherapy damage regulate the flow of vital energy, blood stasis dispelling, reduce phlegm, heat clearing away, sending down the abnormal ascending QI, the method calmed the nerves。The present invention adopts Radix Caraganae Roseae, Fructus Elaeagni Angustifoliae spleen invigorating, kidney tonifying, nourishing the liver；Semen Podocarpi Macrophylli, Herba Cassiopes selaginoidis regulating qi to disperse stagnation, nourishing blood to tranquillize the mind；River Fructus Melodini Suaveolentis root is enriched blood, heat clearing away；Testa oryzae, Citrus aurantium L. var. amara Engl. are regulated the flow of vital energy the chest stuffiness relieving, stomach function regulating preventing or arresting vomiting；Herba Gonostegiae hirtae heat-clearing and toxic substances removing, spleen invigorating removing food stagnancy, dissipating blood stasis dampness removing；Coprinus atramentarius (Bull.) Fr. (Coprinus sterquilinus Fr.) benefit the intestines and stomach, phlegm-eliminiating and qi-regulating；Concha rapanae thomasianae is calm, antacid, dissipating phlegm and resolving masses。All medicines share, treating both the principal and secondary aspects of a disease, therefore receive victory effect。
Preferably, described chemotherapy of preventing and treating causes the Chinese medicine composition of delayed emesis and is made up of the crude drug of following mass ratio:
Radix Caraganae Roseae 25 parts, 30 parts of Fructus Elaeagni Angustifoliae, Semen Podocarpi Macrophylli 15 parts, Herba Cassiopes selaginoidis 20 parts, river Fructus Melodini Suaveolentis root 20 parts, Testa oryzae 15 parts, Citrus aurantium L. var. amara Engl. 3 parts, Herba Gonostegiae hirtae 25 parts, Coprinus atramentarius (Bull.) Fr. (Coprinus sterquilinus Fr.) 6 parts, Concha rapanae thomasianae 25 parts。
Described chemotherapy of preventing and treating causes the Chinese medicine composition of delayed emesis existing Chinese medicine preparation technology can be adopted to prepare into any conventional oral preparations, such as decocting can be adopted to obtain water decoction said components, it is also possible to described chemotherapy of preventing and treating to be caused the Chinese medicine composition of delayed emesis by other existing Chinese medicine preparation technology and prepare into honeyed pill, condensed water honeyed pill, the watered pill, granule, capsule, tablet, powder, unguentum, oral liquid。
Compared with prior art, beneficial effects of the present invention
Chemotherapy of preventing and treating provided by the invention causes the Chinese medicine composition of delayed emesis, compensate for western medicine chemotherapy and causes the deficiency of delayed emesis, curative effect affirmative, and taking convenience, has no side effect, it is ensured that being smoothed out of chemotherapy。
A kind of chemotherapy of preventing and treating causes the Chinese medicine composition of delayed emesis, and clinical efficacy is summed up
1 physical data
Tumor Patients after Chemotherapy 90 example, wherein male 48 example, women 42 example；Age 31-68 year, average 51.2 years old；Wherein pulmonary carcinoma 26 example, gastric cancer 18 example, esophageal carcinoma 12 example, mammary cancer 14 example, intestinal cancer 12 example, ovarian cancer 8 example。MethodsThe cases enrolled is randomly divided into treatment group and each 45 examples of matched group, two groups of physical data no significant difference (P > 0.05), there is comparability。
2 Therapeutic Method
30min ondansetron 8mg intravenous injection before matched group chemotherapy, continuously injection 3 days, treatment group is oral Chinese medicine composition water decoction provided by the invention on the basis of matched group:
Radix Caraganae Roseae 25 grams, 30 grams of Fructus Elaeagni Angustifoliae, Semen Podocarpi Macrophylli 15 grams, Herba Cassiopes selaginoidis 20 grams, river Fructus Melodini Suaveolentis root 20 grams, Testa oryzae 15 grams, Citrus aurantium L. var. amara Engl. 3 grams, Herba Gonostegiae hirtae 25 grams, Coprinus atramentarius (Bull.) Fr. (Coprinus sterquilinus Fr.) 6 grams, Concha rapanae thomasianae 25 grams, conventionally Chinese medicine preparation technology makes water decoction, within first 1 day, take in chemotherapy, everyone every day 1 dose, it serve on 7 days。
3 therapeutic outcomes
3.1 criterions of therapeutical effect: reference World Health Organization (WHO) (WHO) standard (Zhou Jichang. practical Internal Medicine-Oncology. Beijing: People's Health Publisher, 2000:22-24.), by how many nausea and vomiting number of times is divided into effective: without nausea and vomiting in 24 hours；Effective: n or V 2-3 time in 24 hours；Invalid: n or V > 4 times in 24 hours。
3.2 results: effective 33 examples for the treatment of group, effective 17 examples, invalid 5 examples, total effective rate 88.9%；Effective 12 examples of matched group, effective 15 examples, invalid 18 examples, total effective rate 60.0%。Two groups of total effective rates are compared, difference statistically significant (P < 0.05)。
4 model cases
Certain, male together, 51 years old, because of gastric cancer undergoing chemotherapy。30min ondansetron 8mg intravenous injection before chemotherapy, continuously injection 3 days, start oral Chinese medicine composition water decoction provided by the invention for first 1 day in chemotherapy simultaneously, every day 1 dose, serve on 7 days。During Chemotherapy in Patients and in 7 days thereafter, the gastrointestinal reactions such as nausea and vomiting do not occur。
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is described in further detail。But this should not being interpreted as, the scope of the above-mentioned theme of the present invention is only limitted to below example, and all technology realized based on present invention belong to the scope of the present invention。
Embodiment 1
A kind of chemotherapy of preventing and treating causes the Chinese medicine composition of delayed emesis, it is by Radix Caraganae Roseae 30 grams, 35 grams of Fructus Elaeagni Angustifoliae, Semen Podocarpi Macrophylli 20 grams, Herba Cassiopes selaginoidis 25 grams, river Fructus Melodini Suaveolentis root 25 grams, Testa oryzae 20 grams, Citrus aurantium L. var. amara Engl. 4 grams, Herba Gonostegiae hirtae 30 grams, Coprinus atramentarius (Bull.) Fr. (Coprinus sterquilinus Fr.) 9 grams, Concha rapanae thomasianae 30 grams, conventionally Chinese medicine preparation technology makes water decoction, within first 1 day, take in chemotherapy, everyone every day 1 dose, it serve on 7 days。
Embodiment 2
A kind of chemotherapy of preventing and treating causes the Chinese medicine composition of delayed emesis, it is by Radix Caraganae Roseae 25 grams, 30 grams of Fructus Elaeagni Angustifoliae, Semen Podocarpi Macrophylli 15 grams, Herba Cassiopes selaginoidis 20 grams, river Fructus Melodini Suaveolentis root 20 grams, Testa oryzae 15 grams, Citrus aurantium L. var. amara Engl. 3 grams, Herba Gonostegiae hirtae 25 grams, Coprinus atramentarius (Bull.) Fr. (Coprinus sterquilinus Fr.) 6 grams, Concha rapanae thomasianae 25 grams, conventionally Chinese medicine preparation technology makes water decoction, within first 1 day, take in chemotherapy, everyone every day 1 dose, it serve on 7 days。
Embodiment 3
A kind of chemotherapy of preventing and treating causes the Chinese medicine composition of delayed emesis, it is by Radix Caraganae Roseae 20 grams, 25 grams of Fructus Elaeagni Angustifoliae, Semen Podocarpi Macrophylli 10 grams, Herba Cassiopes selaginoidis 15 grams, river Fructus Melodini Suaveolentis root 15 grams, Testa oryzae 10 grams, Citrus aurantium L. var. amara Engl. 2 grams, Herba Gonostegiae hirtae 20 grams, Coprinus atramentarius (Bull.) Fr. (Coprinus sterquilinus Fr.) 3 grams, Concha rapanae thomasianae 20 grams, conventionally Chinese medicine preparation technology makes water decoction, within first 1 day, take in chemotherapy, everyone every day 1 dose, it serve on 7 days。

Claims (3)

1. prevent and treat chemotherapy and cause the Chinese medicine composition of delayed emesis for one kind, it is characterised in that be made up of the crude drug of following mass ratio:
Radix Caraganae Roseae 20-30 part, Fructus Elaeagni Angustifoliae 25-35 part, Semen Podocarpi Macrophylli 10-20 part, Herba Cassiopes selaginoidis 15-25 part, river Fructus Melodini Suaveolentis root 15-25 part, Testa oryzae 10-20 part, Citrus aurantium L. var. amara Engl. 2-4 part, Herba Gonostegiae hirtae 20-30 part, Coprinus atramentarius (Bull.) Fr. (Coprinus sterquilinus Fr.) 3-9 part, Concha rapanae thomasianae 20-30 part。
2. prevent and treat chemotherapy as claimed in claim 1 and cause the Chinese medicine composition of delayed emesis, it is characterised in that be made up of the crude drug of following mass ratio:
Radix Caraganae Roseae 25 parts, 30 parts of Fructus Elaeagni Angustifoliae, Semen Podocarpi Macrophylli 15 parts, Herba Cassiopes selaginoidis 20 parts, river Fructus Melodini Suaveolentis root 20 parts, Testa oryzae 15 parts, Citrus aurantium L. var. amara Engl. 3 parts, Herba Gonostegiae hirtae 25 parts, Coprinus atramentarius (Bull.) Fr. (Coprinus sterquilinus Fr.) 6 parts, Concha rapanae thomasianae 25 parts。
3. prevent and treat the preparation method that chemotherapy causes the Chinese medicine composition of delayed emesis as claimed in claim 1, it is characterised in that the Chinese medicinal components of described mass ratio is prepared into water decoction, honeyed pill, condensed water honeyed pill, the watered pill, granule, capsule, tablet, powder, unguentum, oral liquid。
CN201610181325.3A 2016-03-25 2016-03-25 Traditional Chinese medicine composition for preventing and treating delayed emesis caused by chemotherapy Pending CN105687875A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105250650A (en) * 2015-11-19 2016-01-20 王学叶 Traditional Chinese medicine preparation for treating functional vomiting

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105250650A (en) * 2015-11-19 2016-01-20 王学叶 Traditional Chinese medicine preparation for treating functional vomiting

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
弓晓霞: "大柴胡汤加味治疗化疗致迟发性呕吐", 《湖北中医杂志》 *

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