CN105687538A

CN105687538A - Drug for treating anterior pituitary hypofunction

Info

Publication number: CN105687538A
Application number: CN201610139956.9A
Authority: CN
Inventors: 庄甲菁
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-03-11
Filing date: 2016-03-11
Publication date: 2016-06-22

Abstract

The invention relates to a drug for treating anterior pituitary hypofunction. The drug is prepared from raw materials in parts by weight as follows: 8 parts of fortune eupatorium herbs, 5 parts of akebia stems, 10 parts of common curculigo rhizomes, 6 parts of Salvia aerea, 15 parts of desertliving cistanche, 8 parts of glossy privet fruits and 9 parts of Chinese silkvine root-bark. The fortune eupatorium herbs have effects of relieving summer-heat, resolving dampness, repelling foulness and harmonizing the center; the akebia stems have effects of clearing heat, promoting diuresis, activating blood circulation and freeing vessels; the common curculigo rhizomes have effects of warming the kidney, tonifying yang and dispelling cold-dampness; the Salvia aerea has effects of tonifying the kidney, strengthening bones, activating blood circulation, regulating menstruation, cooling blood and stopping bleeding; the desertliving cistanche has effects of recuperating kidney yang, benefiting essence and blood and moistening intestinal tracts; the glossy privet fruits have effects of tonifying the liver and the kidney, clearing deficiency-heat and improving eyesight; the Chinese silkvine root-bark has effects of expelling wind-dampness, inducing diuresis, alleviating edema and strengthening the heart. The medicines are combined for use and have effects of nourishing the liver, nourishing and warming the kidney, activating yang, reducing phlegm, inducing resuscitation, tonifying the kidney and regulating thoroughfare vessels. Clinical tests prove that the drug can treat the anterior pituitary hypofunction safely and effectively.

Description

A kind of medicine for treating hypofunction of anterior pituitary

Technical field

The present invention relates to a kind of Chinese medicine, be specifically related to a kind of medicine for treating hypofunction of anterior pituitary。

Background technology

The multiple disease damage of hypofunction of anterior pituitary system hypothalamus or hypophysis, make hypophysis all or the damaged rear hypoendocrinism disease caused of the overwhelming majority, this disease is divided into again constitutional and Secondary cases two class, the former is caused by pituitary cytoclasis, the latter is owing to hypothalamic lesion causes caused by hypophysoprivus stimulation, common with the former clinically。With pallor Mental fatigue, the cold physique soreness of waist, hyposexuality, alopecia, mastatrophy, the disease such as amenorrhea is main clinical characteristics。Primary disease most commonly encountered diseases is because of study in postpartum pituitary ischemic necrosis and pituitary tumor。The former sees the puerpera of massive hemorrhage during childbirth, if the latter falls ill when child, can cause pituitary dwarfism。, can there is hypofunction of anterior pituitary crisis, especially neurological involvement in primary disease severe patient, normal spiritedness is not normal, vomiting, even goes into a coma, gives treatment to too late, can threat to life。

Hypofunction of anterior pituitary belongs to the categories such as the traditional Chinese medical science " asthenia ", " amenorrhea "。

The cause of disease

1. hypophysis and neighbouring oncothlipsis thereof or infiltration

Including tumor or Malignant tumor of bonal metastasis, infiltration etc. on pituitary tumor, saddle side or saddle。

2. hypophysis ischemic necrosis

It is most commonly that postpartum hemorrhage (Sheehan syndrome)。Other also include diabetic angiopathy, atherosclerosis, eclamposia, temporal arteritis etc.。

3. hypophysis operation, wound, radiation injury or pituitary apoplexy

4. various intracranial infections or inflammation cause hypophysis to destroy

Such as viral encephalitis, tuberculous meningitis, purulent meningitis, autoimmune hypophysitis, fungal infection etc.。

5. empty sellaturcica

6. other

Including metabolism disorder (chronic kidney hypofunction may occur in which that GnRH and TSH secretion is low), sarcoidosis, granuloma etc.。

Clinical manifestation

Anterior pituitary hormone hyposecretion

Causing the series of symptoms of respective target adenasthenia, sign, its order of severity is relevant to hormonoprivia degree。It is generally believed that anterior pituitary hormone is not enough often first occurs that GH and GnRH is not enough, it is later that TSH and ACTH lacks appearance。

1. growth hormone secretion is not enough: adult is without substantially performance, and some patients may occur in which that fasting glucose is low, fracture repair slows down, and child GH lacks and growth retardation or stagnation then occurs。

2. gonadotrophin secretion is not enough: hyposexuality。Female patient infrequent menstruation or amenorrhea, pubes, armpit hair rareness or disappearance, breast and atrophy of external genitalia；Male patient's beard is rare, and pubes, axillary trichomadesis, sexual impotence, testis diminishes, deliquescing, muscle weakness, aedoeatrophia。Then there is sexual development obstacle in child。

3. thyrotropin hyposecretion: be afraid of cold, hypothermia, poor appetite, abdominal distention, constipation, slow in one's movements, bradykinesia, face edema due to deficiency, xerosis cutis, celostomia, hypotrichosis, milphae, heart rate slow, severe patient may occur in which that solid edema, mind are indifferent, numb and even goes into a coma。Some patients may occur in which hyperlipemia and carotenemia, but obvious not as former hypothyroidism。Child plays patient and shows as growth retardation, retardation of bone age, dysnoesia。

4. thyroliberin hyposecretion: loss of appetite, lose weight, whole body is weak and feeble, resistance is poor, easy infection。The symptom of hypotension, hypoglycemia, low blood sodium often occur, severe patient may occur in which the crisis performance such as Nausea and vomiting, high heat, shock。

5. other: pituitary hormone lack lactotropin lack postpartum agalorrhea often occurs。

By pituitary tumor causer

Except above-mentioned performance occurs, also has the pituitary tumor clinical manifestation to the symptom of surrounding compressing appearance, sign and pituitary tumor itself。Oncothlipsis can cause headache, visual deterioration, defect of visual field, diplopia, blind etc., some patients it may also occur that cerebrospinal rhinorrhea, diabetes insipidus。GH tumor may occur in which a series of performances etc. of acromegaly。

Drug therapy

1. adrenocortical hormone

It is the primary treatment treating full hypofunction of anterior pituitary, prior to the replacement of thyroxin and gonadal hormone。First-selected hydrocortisone (hydrocortisone) or cortisone (cortin) or prednisone (prednisone), taking principle is minimum effective replacement dosage。Severe infections, major operation etc. seriously stress time, quiet of hydrocortisone can be given, it is to avoid occur crisis。

2. thyroxin

Low dose starts progressively dosage extremely minimum effective replacement amount。After supplementary adrenocortical hormone 1～2 week, thyroxine (L-T4) can be supplemented, or used desiccated thyroid tablet, be gradually added to maintenance dose。When dosage is bigger, graded is taken, to coronary heart disease, Patients with Myocardial Ischemia or gerontal patient more it should be noted that start slow dosage from low dose。

3. gonadal hormone

Women at fertile age should set up artificial cycle, recovers secondary sex characteristics and sexual function, it is prevented that osteoporosis。Male uses androgen replacement therapy, to maintain secondary sex characteristics and libido。

4. other treatment

Growth hormone and general symptomatic treatment etc. can be used before osteophiphysis including child。

5. treatment by Chinese herbs

Start with marrow, whole body therapeutic, make disease start to take a turn for the better, human body recovers normal physiological function。

Medical material involved in the present invention is all recorded in " China's book on Chinese herbal medicine " as seen。

Summary of the invention

It is desirable to provide a kind of medicine for treating hypofunction of anterior pituitary, by selecting suitable medical material and proportioning thereof, reach safely and effectively to cure the purpose of hypofunction of anterior pituitary。

In order to achieve the above object, the present invention is by the following technical solutions:

A kind of medicine for treating hypofunction of anterior pituitary, it is characterised in that it is to be prepared from by the raw medicinal material of following weight proportion: Herba Eupatorii 8 parts, Caulis Akebiae 5 parts, Rhizoma Curculiginis 10 parts, RADIX SALVIAE MILTIORRHIZAE 6 parts, Herba Cistanches 15 parts, Fructus Ligustri Lucidi 8 parts, Cortex Periplocae 9 parts。

Illustrate the method have the benefit that below in conjunction with theories of Chinese materia medica

It has been recognised by the inventors that the main cause of disease of hypofunction of anterior pituitary is postpartum hemorrhage, wasting of QI following consumption of blood, caused by kidney mistake is supplemented nutrition。Pathological change is delivery and feed infant fetus, has caused nephrons deficient, postpartum hemorrhage, more makes essence and blood suddenly lose, wasting of QI following consumption of blood, and kidney yang is difficult to supplement nutrition, and the gate of vitality is mutually fiery on the decline, and life can not be broken out, and sees weak, and libido is indifferent, sex character atrophy as。Again because QI and blood is lost greatly, Liver and kidney essence and blood loses and fills, and rushes wantonly two deficient pulses and loses, and causes milk and do not secrete。Amenorrhea and alopecia etc.。The kidney being the origin of congenital constitution, and board is the foundation of acquired constitution, and both grow mutually, interdepends, and mutually balances, and insufficiency of kidney-YANG loses, and spleen sun also loses warm, and the card causing deficiency of spleen-YANG and kidneyYANG eventually is all existing。Therefore kidney invigorating and YANG supporting, benefiting QI and nourishing blood, spleen invigorating the kidney warming are then taked in treatment, qi-restoratives adjusts punching。

The present invention use: Herba Eupatorii expelling summer-heat and damp, ward off dirty and in；Caulis Akebiae clearing away heat and promoting diuresis, blood circulation and channel invigorating；Rhizoma Curculiginis the kidney warming sun is strengthened, and dispels cold-damp；RADIX SALVIAE MILTIORRHIZAE invigorating the kidney and strengthening the bones, promoting blood flow to regulate menstruation, cooling blood for hemostasis；Herba Cistanches kidney-replenishing, benefiting essence-blood, intestine moistening road；Fructus Ligustri Lucidi liver and kidney tonifying, clearind deficient heat, improving eyesight；Cortex Periplocae wind-damp dispelling, inducing diuresis to remove edema, heart tonifying。All medicines share, reach nourishing the liver and kidney, the kidney warming activates yang, waking up the patient from unconsciousness by dissipating phlegm, kidney tonifying adjust punching effect。

Below in conjunction with clinical laboratory data, beneficial effects of the present invention is described:

1, physical data

Inventor collects 43 example hypofunction of anterior pituitary patients altogether between in August ,-2015 in June, 2012。It is randomly divided into: treatment group 22 example, matched group 21 example。Male 15 examples of wherein treatment group, female 7 example, 25～63 years old age, the course of disease 5 months～5 years；Matched group man 16 examples, female 5 example, between 22～64 years old age, the course of disease 5 months～6 years。The data such as two groups of sexes, age, courses of disease there was no significant difference, and has comparability。

Diagnostic criteria

1. medical history inquiry: the medical history that can inquire relevant with the cause of disease, such as childbirth massive hemorrhage, hypophysis ischemic necrosis, intracranial vessel pathological changes, Hypothalamus-pituitary tumor etc.。

2. there is multiple endocrine target gland hypofunction disease group, each syndrome can exist individually or simultaneously。

Follicle stimulating hormone (FSH), interstitialcellstimulating hormone (ICSH) (LH) and prolactin antagonist (PRL) hyposecretion syndrome: postpartum agalorrhea, mammary gland atrophy, amenorrhea are sterile, for the feature that this disease occurs at first。Hair often comes off。Male accompanies sexual impotence, hyposexuality or disappearance, female sex organs atrophy, and male testical is soft to be reduced。

Thyrotropin (TSH) hyposecretion syndrome: such as the clinical manifestation of hypothyroidism, but general relatively light, and serum TSH level is reduced to its main differential point。

Thyroliberin (ACTH) hyposecretion syndrome: such as primary adrenal cortical hypofunction person, often has weak, anorexia, loses weight, but the colour of skin shoals, and serum ACTH level is normal or is reduced to its differential point。

3. in blood anterior pituitary hormone such as GH, PRL, TSH, ACTH, FSH, LH etc. all in low-level。Its target gland hormone such as testosterone, E2, FT3, FT4, cortisol levels also reduce, and to the stimulation (such as ACTH stimulation test) of corresponding exogenous hypophysis trophic hormone in delayed response。

1. inclusive criteria meets diagnostic criteria；2. age 18～70 years old；3. compliance is good；4. Informed Consent Form is signed voluntarily。

Exclusion standard 1. gestation, women breast-feeding their children；2. suffer from severe cardiac, lung, liver, renal disease patient；3. spiritedness systemic disease, it is impossible to partner treatment person；4. allergic constitution and those who are allergic to this drug。

2, Therapeutic Method

The capsule that the oral present invention specific embodiment 3 for the treatment of group prepares, every day 3 times。Treat 1 month。

Matched group is administered orally hydrocortisone acetate sheet, each 10mg, every day 3 times。Treat 1 month。

3, criterion of therapeutical effect and therapeutic outcome

3.1 criterions of therapeutical effect

1. recovery from illness: clinical symptom disappearance, antisecosis, indices is normal；

2. effective: clinical symptoms takes a turn for the better, indices improves；

3. invalid: clinical symptoms and Testing index are without improvement。

3.2 treatment statistical results are in Table 1。

1 liang of table group comparitive study

Visible, hypofunction of anterior pituitary can safely and effectively be treated by the medicine that the present invention prepares, and cure rate is high。

Detailed description of the invention

In order to be more fully understood that and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment。

Embodiment 1

Weigh: Herba Eupatorii 8 grams, Caulis Akebiae 5 grams, Rhizoma Curculiginis 10 grams, RADIX SALVIAE MILTIORRHIZAE 6 grams, Herba Cistanches 15 grams, Fructus Ligustri Lucidi 8 grams, Cortex Periplocae 9 grams；Add 8 times amount water, decoct 1.5 hours, filter；Filtering residue adds 6 times amount water, decocts 1 hour, filters；Merging filtrate, is concentrated into 120 grams, must meet the decoct of one day consumption of adult normal。

For treating hypofunction of anterior pituitary。Oral, daily once。

Embodiment 2

Weigh: Herba Eupatorii 8 grams, Caulis Akebiae 5 grams, Rhizoma Curculiginis 10 grams, RADIX SALVIAE MILTIORRHIZAE 6 grams, Herba Cistanches 15 grams, Fructus Ligustri Lucidi 8 grams, Cortex Periplocae 9 grams；Add 10 times amount water, decoct 2 hours, filter；Filtering residue adds 8 times amount water, decocts 1.5 hours, filters；Merging filtrate, concentration, dry, packaging, the powder of one day consumption of adult normal must be met。

For treating hypofunction of anterior pituitary。Oral, every bu is taken for twice sooner or later。

Embodiment 3

Weigh: Herba Eupatorii 8 grams, Caulis Akebiae 5 grams, Rhizoma Curculiginis 10 grams, RADIX SALVIAE MILTIORRHIZAE 6 grams, Herba Cistanches 15 grams, Fructus Ligustri Lucidi 8 grams, Cortex Periplocae 9 grams；Add 6 times amount water, decoct 3 times, decoct 1 hour every time, merge decoction liquor, concentration, dry, load capsule shells, the capsule of one day consumption of adult normal must be met。

For treating hypofunction of anterior pituitary。Oral, every bu morning, noon and afternoon take for three times。

Claims

1. the medicine being used for treating hypofunction of anterior pituitary, it is characterised in that it is to be prepared from by the raw medicinal material of following weight proportion: Herba Eupatorii 8 parts, Caulis Akebiae 5 parts, Rhizoma Curculiginis 10 parts, RADIX SALVIAE MILTIORRHIZAE 6 parts, Herba Cistanches 15 parts, Fructus Ligustri Lucidi 8 parts, Cortex Periplocae 9 parts。

2. a kind of medicine for treating hypofunction of anterior pituitary as claimed in claim 1, it is characterised in that its preparation method is: weigh: Herba Eupatorii 8 parts, Caulis Akebiae 5 parts, Rhizoma Curculiginis 10 parts, RADIX SALVIAE MILTIORRHIZAE 6 parts, Herba Cistanches 15 parts, Fructus Ligustri Lucidi 8 parts, Cortex Periplocae 9 parts；Add 8 times amount water, decoct 1.5 hours, filter；Filtering residue adds 6 times amount water, decocts 1 hour, filters；Merging filtrate, is concentrated into 120 parts, obtains decoct；Above-mentioned part each means weight portion。

3. a kind of medicine for treating hypofunction of anterior pituitary as claimed in claim 1, it is characterised in that its preparation method is: weigh: Herba Eupatorii 8 parts, Caulis Akebiae 5 parts, Rhizoma Curculiginis 10 parts, RADIX SALVIAE MILTIORRHIZAE 6 parts, Herba Cistanches 15 parts, Fructus Ligustri Lucidi 8 parts, Cortex Periplocae 9 parts；Add 10 times amount water, decoct 2 hours, filter；Filtering residue adds 8 times amount water, decocts 1.5 hours, filters；Merging filtrate, concentration, dry, packaging, obtain powder；Above-mentioned part each means weight portion。

4. a kind of medicine for treating hypofunction of anterior pituitary as claimed in claim 1, it is characterised in that its preparation method is: weigh: Herba Eupatorii 8 parts, Caulis Akebiae 5 parts, Rhizoma Curculiginis 10 parts, RADIX SALVIAE MILTIORRHIZAE 6 parts, Herba Cistanches 15 parts, Fructus Ligustri Lucidi 8 parts, Cortex Periplocae 9 parts；Add 6 times amount water, decoct 3 times, decoct 1 hour every time, merge decoction liquor, concentration, dry, load capsule shells, obtain capsule；Above-mentioned part each means weight portion。