CN105687442A - External medicament for treating paronychia and preparation method thereof - Google Patents

External medicament for treating paronychia and preparation method thereof Download PDF

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CN105687442A
CN105687442A CN201610152518.6A CN201610152518A CN105687442A CN 105687442 A CN105687442 A CN 105687442A CN 201610152518 A CN201610152518 A CN 201610152518A CN 105687442 A CN105687442 A CN 105687442A
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extract
parts
cortex phellodendri
herba
topical agent
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卢连伟
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/78—Saururaceae (Lizard's-tail family)
    • A—HUMAN NECESSITIES
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

The invention provides an external medicament for treating paronychia and a preparation method thereof. The external medicament for treating paronychia is mainly prepared from, by weight, 3-8 parts of amur corktree extract, 3-8 parts of herbal centellae extract, 3-8 parts of herbal saururi chinensis extract, 3-7 parts of flos hibisci mutabilis extract, 3-7 parts of uniflower swisscentaury root extract, 3-7 parts of herbal ixeris extract, 2-5 parts of jojoba oil, 1-5 parts of borage oil, 1-1.5 parts of gentamicin sulfate, 1-1.2 parts of betamethasone dipropionate, 0.5-1 part of dexmedetomidine, 2-4 parts of laurinol sulphate, 3-10 parts of borneol, 0.05-0.1 part of emulsion stabilizer, 0.01-0.03 part of preservative and 0.01-0.03 part of antioxidant. Multiple Chinese herbal extracts with the effects of detumescence and apocenosis and western medicine ingredients with the effects of antibiosis and analgesia are under reasonable compatibility and combination, all the medicinal materials complement one another to achieve the effects of blood activating and cooling, detumescence, apocenosis, antisepsis, inflammation removal, sedation and analgesia, and the curative effect on paronychia is accurate. The prepared external medicament is locally delivered, medicine adsorption is good, the effect is taken quickly, and no side effect is generated.

Description

One treats paronychial topical agent and preparation method thereof
Technical field
The invention belongs to medical nursing practical technique field, one treats paronychial topical agent and preparation method thereof specifically。
Background technology
The growing part of fingernail claims onychostroma or nail root, is covered by skin, and the both sides of fingernail connect with skinfold, forms nail groove。The pyogenic infection of paronychia and both sides, nail plate and skinfold joint portion, is one of clinical common finger (toe) portion infectious disease。Pathogenic bacterium are the staphylococcus aureus of skin surface。After various slight wound can be betided。Because toe (refers to) that the first direction of growth is incorrect, cause toe (finger) Jia Pang tissue inflammation, red and swollen, bitterly, the symptom such as suppurate。Inflammation is of long duration, and tissue produces granuloma, makes toe (finger) first sink deeper and deeper, it is not easy to spontaneous recovery。Send out well the big nurse toe of what。Pathogenic bacteria invades from wound, spreads along nail groove。Now subcutaneous tissue hyperemia, edema, leukocyte chemotaxis, the histiocyte degeneration then damaged, necrosis, liquefaction；Form semi-circular abscess。Pus also can spread to the subcutaneous of nail root portion and offside nail groove from nail groove side。
Early stage available hot compress, physical therapy, external application YUSHIZHI RUANGAO or Sanhuang San etc., application sulfonamides or antibiotic。If all invalid with above medicine, select and need to carry out operative treatment。The present invention is contemplated to the deficiency existed for prior art, it is provided that a kind of topical agent evident in efficacy, simply effectively, removes the worry of operative treatment from。
Summary of the invention
Present invention solves the technical problem that being to provide one treats paronychial topical agent and preparation method thereof, this curative effect of medicine is notable, eliminates the worry of operative treatment。
This invention address that above-mentioned technical problem be the technical scheme is that
One treats paronychial topical agent, by weight, mainly consist of the following composition: Cortex Phellodendri extract 3-8 part, Herba Centellae extract 3-8 part, Rhizoma Saururi extract 3-8 part, Flos Hibisci Mutabilis extract 3-7 part, Radix Rhapontici extract 3-7 part, Herba Ixeritis chinensis extract 3-7 part, Jojoba oil 2-5 part, borage oil 1-5 part, gentamycin sulfate 1-1.5 part, betamethasone dipropionate 1-1.2 part, dexmedetomidine 0.5-1 part, lauryl alcohol sulfuric ester 2-4 part, Borneolum Syntheticum 3-10 part, emulsion stabilizer 0.05-0.1 part, preservative 0.01-0.03 part, antioxidant 0.01-0.03 part。
Further, described one treats paronychial topical agent, it is characterised in that by weight, also includes following component: Folium Mori extract 2-5 part, extract from pine needles 2-5 part, Cortex Phellodendri extract 2-5 part。
Further, described emulsion stabilizer is diglycollic amide, and skin irritation is little。
Further, described preservative is sorbic acid, it is prevented that medicine is putrid and deteriorated。
Further, described antioxidant is tocopherol, has good antioxidation。
One treats paronychial topical agent, and its preparation method is:
(1) the dry medical material of Cortex Phellodendri is taken, pulverize with pulverizer, cross 40-100 mesh sieve, add the soak with ethanol 20～30h of the 45-50% of 1-1.6 amount, medical material is made fully to expand, medicated powder is loaded rustless steel leakage tank again, 75～85% ethanol seepages with 9～10 times amount, collect effusion, filter with macroporous adsorptive resins, when gained filtrate reduced in volume is to 75 DEG C, relative density is the thick paste of 1.02～1.16, add 1.6 times amount water fully to stir evenly,-5～0 DEG C of deepfreeze 10～15h, discard precipitate, it is the clear paste of 0.82～0.94 that gained filtrate is condensed into relative density when 75 DEG C, it is Cortex Phellodendri extract；
(2) Herba Centellae, Rhizoma Saururi (Herba Saururi), Flos Hibisci Mutabilis, Radix Rhapontici, Herba Ixeritis chinensis, Folium Mori, Folium Pini, Cortex Phellodendri are taken respectively, extract according to the extraction process of above-mentioned Cortex Phellodendri, respectively obtain Herba Centellae extract, Rhizoma Saururi extract, Flos Hibisci Mutabilis extract, Radix Rhapontici extract, Herba Ixeritis chinensis extract, Folium Mori extract, extract from pine needles, Cortex Phellodendri extract。
(3) respectively by described proportioning weigh step (1) prepare Cortex Phellodendri extract and step (2) prepare Herba Centellae extract, Rhizoma Saururi extract, Flos Hibisci Mutabilis extract, Radix Rhapontici extract, Herba Ixeritis chinensis extract, Folium Mori extract, extract from pine needles, Cortex Phellodendri extract；
(4) Jojoba oil, borage oil, gentamycin sulfate, betamethasone dipropionate, dexmedetomidine, lauryl alcohol sulfuric ester, Borneolum Syntheticum, emulsion stabilizer, preservative, antioxidant are weighed by described proportioning respectively；
(5) require to prepare into topical agent according to pharmacy conventional pharmaceutical method and adjuvant by all the components that above-mentioned steps (3) is got ready with step (4)。
Further, the dosage form of described topical agent includes: ointment, gel, emplastrum etc.。
Further, the preparation method of described ointment is:
30～45 parts of Oleum Sesami are heated to 80 DEG C, adds Jojoba oil and borage oil, stir oil phase；Again described Cortex Phellodendri extract, Herba Centellae extract, Rhizoma Saururi extract, Flos Hibisci Mutabilis extract, Radix Rhapontici extract, Herba Ixeritis chinensis extract, Folium Mori extract, extract from pine needles, Cortex Phellodendri extract are merged, purified water is added by the weight ratio of 1:1.5, heating, to 80 DEG C, obtains aqueous phase；By oil, water two-phase mixtures, add gentamycin sulfate, betamethasone dipropionate, dexmedetomidine, lauryl alcohol sulfuric ester, Borneolum Syntheticum, emulsion stabilizer, preservative, antioxidant, finally add 10～20 parts of lanolines, be stirred continuously, until emulsifying completes and condenses,。
Further, the preparation method of described gel is:
50～80 parts of carbomers are added in appropriate amount of purified water, is stirred to dissolve, adds 20～40 parts of glycerol, 0.2～4.5 part of ethyl hydroxybenzoate, be transferred to pH value to 6.5～7.5 (55) DEG C, make gel-type vehicle；Described Cortex Phellodendri extract, Herba Centellae extract, Rhizoma Saururi extract, Flos Hibisci Mutabilis extract, Radix Rhapontici extract, Herba Ixeritis chinensis extract, Folium Mori extract, extract from pine needles, Cortex Phellodendri extract are merged, and mix with above-mentioned gel-type vehicle, add Jojoba oil, borage oil, gentamycin sulfate, betamethasone dipropionate, dexmedetomidine, lauryl alcohol sulfuric ester, Borneolum Syntheticum, emulsion stabilizer, preservative, antioxidant, stir, stand,。
Further, the preparation method of described emplastrum is:
By 20～30 parts of gelatin, 20～30 parts of alginic acid, 20～30 parts of carbomers, 10～20 parts of glycerol mixing, it is sequentially added into described Cortex Phellodendri extract, Herba Centellae extract, Rhizoma Saururi extract, Flos Hibisci Mutabilis extract, Radix Rhapontici extract, Herba Ixeritis chinensis extract, Folium Mori extract, extract from pine needles, Cortex Phellodendri extract, Jojoba oil, borage oil, gentamycin sulfate, betamethasone dipropionate, dexmedetomidine, lauryl alcohol sulfuric ester, Borneolum Syntheticum, emulsion stabilizer, preservative, antioxidant, add 2～3.5 parts of sticky agents, 1.5～5.0 parts of excipient, warming while stirring is to 60～100 DEG C, after stirring, coat on medical adhesive-bonded fabric, section, ?。
The invention has the beneficial effects as follows: multi-flavor is had the Chinese herbal medicine extract of detumescence and apocenosis effect and carries out rational compatible combination with the western medicine composition with antibacterial analgesic efficacy by the present invention, make to complement each other between each medicine, reach effect of promoting blood circulation and cooling blood, detumescence and apocenosis, anti-inflammation, sedation-analgesia, to the scorching determined curative effect of nail groove。The present invention utilizes the pharmaceutical technology of advanced person to extract medium-height grass the effective elements of the medicine, and active constituent content is high, further makes topical agent, topical, and drug absorption is good, and instant effect has no side effect。
Detailed description of the invention
Embodiment 1:
One treats paronychial topical agent, by weight, mainly consist of the following composition: Cortex Phellodendri extract 3 parts, Herba Centellae extract 3 parts, Rhizoma Saururi extract 3 parts, Flos Hibisci Mutabilis extract 3 parts, Radix Rhapontici extract 3 parts, Herba Ixeritis chinensis extract 3 parts, Jojoba oil 2 parts, borage oil 1 part, gentamycin sulfate 1 part, betamethasone dipropionate 1 part, dexmedetomidine 0.5 part, lauryl alcohol sulfuric ester 2 parts, Borneolum Syntheticum 3 parts, emulsion stabilizer 0.05 part, preservative 0.01 part, antioxidant 0.01 part。
Wherein, described emulsion stabilizer is diglycollic amide, and skin irritation is little；Described preservative is sorbic acid；Described antioxidant is tocopherol。
The preparation method of the paronychial topical agent of this treatment is:
(1) the dry medical material of Cortex Phellodendri is taken, pulverize with pulverizer, cross 40 mesh sieves, the soak with ethanol 20h of the 45% of 1 amount of addition, medical material is made fully to expand, medicated powder is loaded rustless steel leakage tank again, with 75% ethanol seepage of 9 times amount, collect effusion, filter with macroporous adsorptive resins, when gained filtrate reduced in volume is to 75 DEG C, relative density is the thick paste of 1.02, add 1.6 times amount water fully to stir evenly ,-5 DEG C of deepfreeze 10h, discard precipitate, it is the clear paste of 0.82 that gained filtrate is condensed into relative density when 75 DEG C, is Cortex Phellodendri extract；
(2) take Herba Centellae, Rhizoma Saururi (Herba Saururi), Flos Hibisci Mutabilis, Radix Rhapontici, Herba Ixeritis chinensis respectively, extract according to the extraction process of above-mentioned Cortex Phellodendri, respectively obtain Herba Centellae extract, Rhizoma Saururi extract, Flos Hibisci Mutabilis extract, Radix Rhapontici extract, Herba Ixeritis chinensis extract。
(3) respectively by described proportioning weigh step (1) prepare Cortex Phellodendri extract and step (2) prepare Herba Centellae extract, Rhizoma Saururi extract, Flos Hibisci Mutabilis extract, Radix Rhapontici extract, Herba Ixeritis chinensis extract；
(4) Jojoba oil, borage oil, gentamycin sulfate, betamethasone dipropionate, dexmedetomidine, lauryl alcohol sulfuric ester, Borneolum Syntheticum, emulsion stabilizer, preservative, antioxidant are weighed by described proportioning respectively；
(5) require to prepare into ointment according to pharmacy conventional pharmaceutical method and adjuvant by all the components that above-mentioned steps (3) is got ready with step (4):
30 parts of Oleum Sesami are heated to 80 DEG C, adds Jojoba oil and borage oil, stir oil phase；Described Cortex Phellodendri extract, Herba Centellae extract, Rhizoma Saururi extract, Flos Hibisci Mutabilis extract, Radix Rhapontici extract, Herba Ixeritis chinensis extract being merged, add purified water by the weight ratio of 1:1.5, heating, to 80 DEG C, obtains aqueous phase；By oil, water two-phase mixtures, add gentamycin sulfate, betamethasone dipropionate, dexmedetomidine, lauryl alcohol sulfuric ester, Borneolum Syntheticum, emulsion stabilizer, preservative, antioxidant, finally add 10 parts of lanolines, be stirred continuously, until emulsifying completes and condenses,。
Embodiment 2:
One treats paronychial topical agent, by weight, mainly consist of the following composition: Cortex Phellodendri extract 5.5 parts, Herba Centellae extract 5.5 parts, Rhizoma Saururi extract 5.5 parts, Flos Hibisci Mutabilis extract 5 parts, Radix Rhapontici extract 5 parts, Herba Ixeritis chinensis extract 5 parts, Jojoba oil 3.5 parts, borage oil 3 parts, gentamycin sulfate 1.25 parts, betamethasone dipropionate 1.1 parts, dexmedetomidine 0.75 part, lauryl alcohol sulfuric ester 3 parts, Borneolum Syntheticum 6.5 parts, emulsion stabilizer 0.075 part, preservative 0.02 part, antioxidant 0.02 part。
Wherein, described emulsion stabilizer is diglycollic amide, and skin irritation is little；Described preservative is sorbic acid；Described antioxidant is tocopherol。
The preparation method of the paronychial topical agent of this treatment is:
(1) the dry medical material of Cortex Phellodendri is taken, pulverize with pulverizer, cross 70 mesh sieves, the soak with ethanol 25h of the 47.5% of 1.3 amounts of addition, medical material is made fully to expand, medicated powder is loaded rustless steel leakage tank again, with 80% ethanol seepage of 9.5 times amount, collect effusion, filter with macroporous adsorptive resins, when gained filtrate reduced in volume is to 75 DEG C, relative density is the thick paste of 1.09, add 1.6 times amount water fully to stir evenly ,-2.5 DEG C of deepfreeze 12.5h, discard precipitate, it is the clear paste of 0.88 that gained filtrate is condensed into relative density when 75 DEG C, is Cortex Phellodendri extract；
(2) take Herba Centellae, Rhizoma Saururi (Herba Saururi), Flos Hibisci Mutabilis, Radix Rhapontici, Herba Ixeritis chinensis respectively, extract according to the extraction process of above-mentioned Cortex Phellodendri, respectively obtain Herba Centellae extract, Rhizoma Saururi extract, Flos Hibisci Mutabilis extract, Radix Rhapontici extract, Herba Ixeritis chinensis extract。
(3) respectively by described proportioning weigh step (1) prepare Cortex Phellodendri extract and step (2) prepare Herba Centellae extract, Rhizoma Saururi extract, Flos Hibisci Mutabilis extract, Radix Rhapontici extract, Herba Ixeritis chinensis extract；
(4) Jojoba oil, borage oil, gentamycin sulfate, betamethasone dipropionate, dexmedetomidine, lauryl alcohol sulfuric ester, Borneolum Syntheticum, emulsion stabilizer, preservative, antioxidant are weighed by described proportioning respectively；
(5) require to prepare into gel according to pharmacy conventional pharmaceutical method and adjuvant by all the components that above-mentioned steps (3) is got ready with step (4):
65 parts of carbomers are added in appropriate amount of purified water, is stirred to dissolve, adds 30 parts of glycerol, 2.35 parts of ethyl hydroxybenzoates, be transferred to pH value to 7.0 (55) DEG C, make gel-type vehicle；Described Cortex Phellodendri extract, Herba Centellae extract, Rhizoma Saururi extract, Flos Hibisci Mutabilis extract, Radix Rhapontici extract, Herba Ixeritis chinensis extract are merged, and mix with above-mentioned gel-type vehicle, add Jojoba oil, borage oil, gentamycin sulfate, betamethasone dipropionate, dexmedetomidine, lauryl alcohol sulfuric ester, Borneolum Syntheticum, emulsion stabilizer, preservative, antioxidant, stir, stand,。
Embodiment 3:
One treats paronychial topical agent, by weight, mainly consist of the following composition: Cortex Phellodendri extract 8 parts, Herba Centellae extract 8 parts, Rhizoma Saururi extract 8 parts, Flos Hibisci Mutabilis extract 7 parts, Radix Rhapontici extract 7 parts, Herba Ixeritis chinensis extract 7 parts, Jojoba oil 5 parts, borage oil 5 parts, gentamycin sulfate 1.5 parts, betamethasone dipropionate 1.2 parts, dexmedetomidine 1 part, lauryl alcohol sulfuric ester 4 parts, Borneolum Syntheticum 10 parts, emulsion stabilizer 0.1 part, preservative 0.03 part, antioxidant 0.03 part。
Wherein, described emulsion stabilizer is diglycollic amide, and skin irritation is little；Described preservative is sorbic acid；Described antioxidant is tocopherol。
The preparation method of the paronychial topical agent of this treatment is:
(1) the dry medical material of Cortex Phellodendri is taken, pulverize with pulverizer, cross 100 mesh sieves, the soak with ethanol 30h of the 50% of 1.6 amounts of addition, medical material is made fully to expand, medicated powder is loaded rustless steel leakage tank again, with 85% ethanol seepage of 10 times amount, collect effusion, filter with macroporous adsorptive resins, when gained filtrate reduced in volume is to 75 DEG C, relative density is the thick paste of 1.16, add 1.6 times amount water fully to stir evenly, 0 DEG C of deepfreeze 15h, discard precipitate, it is the clear paste of 0.94 that gained filtrate is condensed into relative density when 75 DEG C, is Cortex Phellodendri extract；
(2) take Herba Centellae, Rhizoma Saururi (Herba Saururi), Flos Hibisci Mutabilis, Radix Rhapontici, Herba Ixeritis chinensis respectively, extract according to the extraction process of above-mentioned Cortex Phellodendri, respectively obtain Herba Centellae extract, Rhizoma Saururi extract, Flos Hibisci Mutabilis extract, Radix Rhapontici extract, Herba Ixeritis chinensis extract。
(3) respectively by described proportioning weigh step (1) prepare Cortex Phellodendri extract and step (2) prepare Herba Centellae extract, Rhizoma Saururi extract, Flos Hibisci Mutabilis extract, Radix Rhapontici extract, Herba Ixeritis chinensis extract；
(4) Jojoba oil, borage oil, gentamycin sulfate, betamethasone dipropionate, dexmedetomidine, lauryl alcohol sulfuric ester, Borneolum Syntheticum, emulsion stabilizer, preservative, antioxidant are weighed by described proportioning respectively；
(5) require to prepare into emplastrum according to pharmacy conventional pharmaceutical method and adjuvant by all the components that above-mentioned steps (3) is got ready with step (4):
By 30 parts of gelatin, 30 parts of alginic acid, 30 parts of carbomers, 20 parts of glycerol mixing, it is sequentially added into described Cortex Phellodendri extract, Herba Centellae extract, Rhizoma Saururi extract, Flos Hibisci Mutabilis extract, Radix Rhapontici extract, Herba Ixeritis chinensis extract, Jojoba oil, borage oil, gentamycin sulfate, betamethasone dipropionate, dexmedetomidine, lauryl alcohol sulfuric ester, Borneolum Syntheticum, emulsion stabilizer, preservative, antioxidant, add 3.5 parts of sticky agents, 5.0 parts of excipient, warming while stirring is to 100 DEG C, after stirring, coat on medical adhesive-bonded fabric, section,。
Embodiment 4:
One treats paronychial topical agent, by weight, mainly consist of the following composition: Cortex Phellodendri extract 3 parts, Herba Centellae extract 3 parts, Rhizoma Saururi extract 3 parts, Flos Hibisci Mutabilis extract 3 parts, Radix Rhapontici extract 3 parts, Herba Ixeritis chinensis extract 3 parts, Jojoba oil 2 parts, borage oil 1 part, gentamycin sulfate 1 part, betamethasone dipropionate 1 part, dexmedetomidine 0.5 part, lauryl alcohol sulfuric ester 2 parts, Borneolum Syntheticum 3 parts, emulsion stabilizer 0.05 part, preservative 0.01 part, antioxidant 0.01 part, Folium Mori extract 2 parts, extract from pine needles 2 parts, Cortex Phellodendri extract 2 parts。
Wherein, described emulsion stabilizer is diglycollic amide, and skin irritation is little；Described preservative is sorbic acid；Described antioxidant is tocopherol。
The preparation method of the paronychial topical agent of this treatment is:
(1) the dry medical material of Cortex Phellodendri is taken, pulverize with pulverizer, cross 40 mesh sieves, the soak with ethanol 20h of the 45% of 1 amount of addition, medical material is made fully to expand, medicated powder is loaded rustless steel leakage tank again, with 75% ethanol seepage of 9 times amount, collect effusion, filter with macroporous adsorptive resins, when gained filtrate reduced in volume is to 75 DEG C, relative density is the thick paste of 1.02, add 1.6 times amount water fully to stir evenly ,-5 DEG C of deepfreeze 10h, discard precipitate, it is the clear paste of 0.82 that gained filtrate is condensed into relative density when 75 DEG C, is Cortex Phellodendri extract；
(2) Herba Centellae, Rhizoma Saururi (Herba Saururi), Flos Hibisci Mutabilis, Radix Rhapontici, Herba Ixeritis chinensis, Folium Mori, Folium Pini, Cortex Phellodendri are taken respectively, extract according to the extraction process of above-mentioned Cortex Phellodendri, respectively obtain Herba Centellae extract, Rhizoma Saururi extract, Flos Hibisci Mutabilis extract, Radix Rhapontici extract, Herba Ixeritis chinensis extract, Folium Mori extract, extract from pine needles, Cortex Phellodendri extract。
(3) respectively by described proportioning weigh step (1) prepare Cortex Phellodendri extract and step (2) prepare Herba Centellae extract, Rhizoma Saururi extract, Flos Hibisci Mutabilis extract, Radix Rhapontici extract, Herba Ixeritis chinensis extract, Folium Mori extract, extract from pine needles, Cortex Phellodendri extract；
(4) Jojoba oil, borage oil, gentamycin sulfate, betamethasone dipropionate, dexmedetomidine, lauryl alcohol sulfuric ester, Borneolum Syntheticum, emulsion stabilizer, preservative, antioxidant are weighed by described proportioning respectively；
(5) require to prepare into ointment according to pharmacy conventional pharmaceutical method and adjuvant by all the components that above-mentioned steps (3) is got ready with step (4):
30 parts of Oleum Sesami are heated to 80 DEG C, adds Jojoba oil and borage oil, stir oil phase；Again described Cortex Phellodendri extract, Herba Centellae extract, Rhizoma Saururi extract, Flos Hibisci Mutabilis extract, Radix Rhapontici extract, Herba Ixeritis chinensis extract, Folium Mori extract, extract from pine needles, Cortex Phellodendri extract are merged, purified water is added by the weight ratio of 1:1.5, heating, to 80 DEG C, obtains aqueous phase；By oil, water two-phase mixtures, add gentamycin sulfate, betamethasone dipropionate, dexmedetomidine, lauryl alcohol sulfuric ester, Borneolum Syntheticum, emulsion stabilizer, preservative, antioxidant, finally add 10 parts of lanolines, be stirred continuously, until emulsifying completes and condenses,。
Embodiment 5:
One treats paronychial topical agent, by weight, mainly consist of the following composition: Cortex Phellodendri extract 5.5 parts, Herba Centellae extract 5.5 parts, Rhizoma Saururi extract 5.5 parts, Flos Hibisci Mutabilis extract 5 parts, Radix Rhapontici extract 5 parts, Herba Ixeritis chinensis extract 5 parts, Jojoba oil 3.5 parts, borage oil 3 parts, gentamycin sulfate 1.25 parts, betamethasone dipropionate 1.1 parts, dexmedetomidine 0.75 part, lauryl alcohol sulfuric ester 3 parts, Borneolum Syntheticum 6.5 parts, emulsion stabilizer 0.075 part, preservative 0.02 part, antioxidant 0.02 part, Folium Mori extract 3.5 parts, extract from pine needles 3.5 parts, Cortex Phellodendri extract 3.5 parts。
Wherein, described emulsion stabilizer is diglycollic amide, and skin irritation is little；Described preservative is sorbic acid；Described antioxidant is tocopherol。
The preparation method of the paronychial topical agent of this treatment is:
(1) the dry medical material of Cortex Phellodendri is taken, pulverize with pulverizer, cross 70 mesh sieves, the soak with ethanol 25h of the 47.5% of 1.3 amounts of addition, medical material is made fully to expand, medicated powder is loaded rustless steel leakage tank again, with 80% ethanol seepage of 9.5 times amount, collect effusion, filter with macroporous adsorptive resins, when gained filtrate reduced in volume is to 75 DEG C, relative density is the thick paste of 1.09, add 1.6 times amount water fully to stir evenly ,-2.5 DEG C of deepfreeze 12.5h, discard precipitate, it is the clear paste of 0.88 that gained filtrate is condensed into relative density when 75 DEG C, is Cortex Phellodendri extract；
(2) Herba Centellae, Rhizoma Saururi (Herba Saururi), Flos Hibisci Mutabilis, Radix Rhapontici, Herba Ixeritis chinensis, Folium Mori, Folium Pini, Cortex Phellodendri are taken respectively, extract according to the extraction process of above-mentioned Cortex Phellodendri, respectively obtain Herba Centellae extract, Rhizoma Saururi extract, Flos Hibisci Mutabilis extract, Radix Rhapontici extract, Herba Ixeritis chinensis extract, Folium Mori extract, extract from pine needles, Cortex Phellodendri extract。
(3) respectively by described proportioning weigh step (1) prepare Cortex Phellodendri extract and step (2) prepare Herba Centellae extract, Rhizoma Saururi extract, Flos Hibisci Mutabilis extract, Radix Rhapontici extract, Herba Ixeritis chinensis extract, Folium Mori extract, extract from pine needles, Cortex Phellodendri extract；
(4) Jojoba oil, borage oil, gentamycin sulfate, betamethasone dipropionate, dexmedetomidine, lauryl alcohol sulfuric ester, Borneolum Syntheticum, emulsion stabilizer, preservative, antioxidant are weighed by described proportioning respectively；
(5) require to prepare into gel according to pharmacy conventional pharmaceutical method and adjuvant by all the components that above-mentioned steps (3) is got ready with step (4):
65 parts of carbomers are added in appropriate amount of purified water, is stirred to dissolve, adds 30 parts of glycerol, 2.35 parts of ethyl hydroxybenzoates, be transferred to pH value to 7.0 (55) DEG C, make gel-type vehicle；Described Cortex Phellodendri extract, Herba Centellae extract, Rhizoma Saururi extract, Flos Hibisci Mutabilis extract, Radix Rhapontici extract, Herba Ixeritis chinensis extract, Folium Mori extract, extract from pine needles, Cortex Phellodendri extract are merged, and mix with above-mentioned gel-type vehicle, add Jojoba oil, borage oil, gentamycin sulfate, betamethasone dipropionate, dexmedetomidine, lauryl alcohol sulfuric ester, Borneolum Syntheticum, emulsion stabilizer, preservative, antioxidant, stir, stand,。
Embodiment 6:
One treats paronychial topical agent, by weight, mainly consist of the following composition: Cortex Phellodendri extract 8 parts, Herba Centellae extract 8 parts, Rhizoma Saururi extract 8 parts, Flos Hibisci Mutabilis extract 7 parts, Radix Rhapontici extract 7 parts, Herba Ixeritis chinensis extract 7 parts, Jojoba oil 5 parts, borage oil 5 parts, gentamycin sulfate 1.5 parts, betamethasone dipropionate 1.2 parts, dexmedetomidine 1 part, lauryl alcohol sulfuric ester 4 parts, Borneolum Syntheticum 10 parts, emulsion stabilizer 0.1 part, preservative 0.03 part, antioxidant 0.03 part, Folium Mori extract 5 parts, extract from pine needles 5 parts, Cortex Phellodendri extract 5 parts。
Wherein, described emulsion stabilizer is diglycollic amide, and skin irritation is little；Described preservative is sorbic acid；Described antioxidant is tocopherol。
The preparation method of the paronychial topical agent of this treatment is:
(1) the dry medical material of Cortex Phellodendri is taken, pulverize with pulverizer, cross 100 mesh sieves, the soak with ethanol 30h of the 50% of 1.6 amounts of addition, medical material is made fully to expand, medicated powder is loaded rustless steel leakage tank again, with 85% ethanol seepage of 10 times amount, collect effusion, filter with macroporous adsorptive resins, when gained filtrate reduced in volume is to 75 DEG C, relative density is the thick paste of 1.16, add 1.6 times amount water fully to stir evenly, 0 DEG C of deepfreeze 15h, discard precipitate, it is the clear paste of 0.94 that gained filtrate is condensed into relative density when 75 DEG C, is Cortex Phellodendri extract；
(2) Herba Centellae, Rhizoma Saururi (Herba Saururi), Flos Hibisci Mutabilis, Radix Rhapontici, Herba Ixeritis chinensis, Folium Mori, Folium Pini, Cortex Phellodendri are taken respectively, extract according to the extraction process of above-mentioned Cortex Phellodendri, respectively obtain Herba Centellae extract, Rhizoma Saururi extract, Flos Hibisci Mutabilis extract, Radix Rhapontici extract, Herba Ixeritis chinensis extract, Folium Mori extract, extract from pine needles, Cortex Phellodendri extract。
(3) respectively by described proportioning weigh step (1) prepare Cortex Phellodendri extract and step (2) prepare Herba Centellae extract, Rhizoma Saururi extract, Flos Hibisci Mutabilis extract, Radix Rhapontici extract, Herba Ixeritis chinensis extract, Folium Mori extract, extract from pine needles, Cortex Phellodendri extract；
(4) Jojoba oil, borage oil, gentamycin sulfate, betamethasone dipropionate, dexmedetomidine, lauryl alcohol sulfuric ester, Borneolum Syntheticum, emulsion stabilizer, preservative, antioxidant are weighed by described proportioning respectively；
(5) require to prepare into emplastrum according to pharmacy conventional pharmaceutical method and adjuvant by all the components that above-mentioned steps (3) is got ready with step (4):
By 30 parts of gelatin, 30 parts of alginic acid, 30 parts of carbomers, 20 parts of glycerol mixing, it is sequentially added into described Cortex Phellodendri extract, Herba Centellae extract, Rhizoma Saururi extract, Flos Hibisci Mutabilis extract, Radix Rhapontici extract, Herba Ixeritis chinensis extract, Folium Mori extract, extract from pine needles, Cortex Phellodendri extract, Jojoba oil, borage oil, gentamycin sulfate, betamethasone dipropionate, dexmedetomidine, lauryl alcohol sulfuric ester, Borneolum Syntheticum, emulsion stabilizer, preservative, antioxidant, add 3.5 parts of sticky agents, 5.0 parts of excipient, warming while stirring is to 100 DEG C, after stirring, coat on medical adhesive-bonded fabric, section, ?。
Below in conjunction with clinical laboratory data, beneficial effects of the present invention is described:
1, physical data:
Inventor collected paronychia patient 360 example altogether to 2013 in January, 2012 between December, be all from Dermatology Outpatient Department, 23～58 years old age, male 80 example, women 70 example。The course of disease 7 days～2 years。
Diagnostic criteria:
I phase: toenail structural integrity, side nail fold is red and swollen, keratinization hypertrophy, and toenail edge likely buries to red and swollen pleat, and without sepage, extruding can have pain in first week；
II phase: toenail has obvious deformation, continuing the pain and the pus discharge that increase the weight of, during beginning, effluent is thin serum sample secretions, and along with increasing the weight of of infecting, secretions becomes purulence frowziness。Having granulation hyperplasia but relatively light, the relatively strong side of nail groove is deep, but separately first week tissue still can appear side nail margin；
III phase: toenail gross distortion, deck level is low, lateral nail fold chronic inflammatory disease and surrounding soft tissue's hypertrophy, forms inflammatory granuloma, and separately tissue can not appear side nail margin first week, can be described as again ingrowing nail paronychia；
IV phase: repeated multiple times first of pulling out, first area significantly reduces, and has pigmentation both sides first week, and chronic ingrowing nail is formed, or chela sample toenail occurs。
Meet above-mentioned diagnostic criteria, the age patient more than 18 years old。
Exclusion standard: trimester of pregnancy, women breast-feeding their children；Merge serious cardiopulmonary hepatorenal disease person。
2, test method: all patients are randomly divided into 4 groups, often organize 90 people, respectively matched group, treatment group 1, treatment group 2, treatment group 3, matched group uses YUSHIZHI RUANGAO to treat, treatment group 1, treatment group 2, treatment group 3 use the medicament that the embodiment of the present invention 1, embodiment 3, embodiment 5 prepare to treat respectively, every day 3 times。Within 1 week, it is a course for the treatment of, 3 courses for the treatment of of treatment altogether。
3, criterion of therapeutical effect
Judge according to " diagnosis of paronychia disease and efficacy assessment standard "。
Effective: after treatment, symptom substantially alleviates, congestion and swelling pain disappears, and function is normal。
Effective: after treatment, symptom alleviates, congestion and swelling pain alleviates, and gently presses toe (finger) first pain, function limitation。
Invalid: symptom is without being clearly better, it is necessary to pull out first。
4, therapeutic outcome part table 1
Table 1
Group Effective/people Effectively/people Invalid/people Total effective rate/%
Matched group 12 54 24 73.3
Treatment group 1 45 42 3 96.7
Treatment group 2 56 32 2 97.8
Treatment group 3 51 37 2 97.8
Visible by treating data above, the therapeutic effect of topical agent of the present invention is substantially better than YUSHIZHI RUANGAO, and during treatment, all patients are showed no other obvious adverse reaction。Visible present invention with medicament is used for treating paronychia safely and effectively, has the value of popularization and application。
The foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, for a person skilled in the art, the present invention can have various modifications and variations。All within the spirit and principles in the present invention, any amendment of making, equivalent replacement, improvement etc., should be included within protection scope of the present invention。

Claims (7)

1. treat paronychial topical agent for one kind, it is characterized in that, by weight, mainly consist of the following composition: Cortex Phellodendri extract 3-8 part, Herba Centellae extract 3-8 part, Rhizoma Saururi extract 3-8 part, Flos Hibisci Mutabilis extract 3-7 part, Radix Rhapontici extract 3-7 part, Herba Ixeritis chinensis extract 3-7 part, Jojoba oil 2-5 part, borage oil 1-5 part, gentamycin sulfate 1-1.5 part, betamethasone dipropionate 1-1.2 part, dexmedetomidine 0.5-1 part, lauryl alcohol sulfuric ester 2-4 part, Borneolum Syntheticum 3-10 part, emulsion stabilizer 0.05-0.1 part, preservative 0.01-0.03 part, antioxidant 0.01-0.03 part。
2. one as claimed in claim 1 treats paronychial topical agent, it is characterised in that by weight, also include following component: Folium Mori extract 2-5 part, extract from pine needles 2-5 part, Cortex Phellodendri extract 2-5 part。
3. one as claimed in claim 1 treats paronychial topical agent, it is characterised in that described emulsion stabilizer is diglycollic amide。
4. one as claimed in claim 1 treats paronychial topical agent, it is characterised in that described preservative is sorbic acid。
5. one as claimed in claim 1 treats paronychial topical agent, it is characterised in that described antioxidant is tocopherol。
6. one as claimed in claim 1 treats paronychial topical agent, it is characterised in that preparation method is:
(1) the dry medical material of Cortex Phellodendri is taken, pulverize with pulverizer, cross 40-100 mesh sieve, add the soak with ethanol 20～30h of the 45-50% of 1-1.6 amount, medical material is made fully to expand, medicated powder is loaded rustless steel leakage tank again, 75～85% ethanol seepages with 9～10 times amount, collect effusion, filter with macroporous adsorptive resins, when gained filtrate reduced in volume is to 75 DEG C, relative density is the thick paste of 1.02～1.16, add 1.6 times amount water fully to stir evenly,-5～0 DEG C of deepfreeze 10～15h, discard precipitate, it is the clear paste of 0.82～0.94 that gained filtrate is condensed into relative density when 75 DEG C, it is Cortex Phellodendri extract；
(2) Herba Centellae, Rhizoma Saururi (Herba Saururi), Flos Hibisci Mutabilis, Radix Rhapontici, Herba Ixeritis chinensis, Folium Mori, Folium Pini, Cortex Phellodendri are taken respectively, extract according to the extraction process of above-mentioned Cortex Phellodendri, respectively obtain Herba Centellae extract, Rhizoma Saururi extract, Flos Hibisci Mutabilis extract, Radix Rhapontici extract, Herba Ixeritis chinensis extract, Folium Mori extract, extract from pine needles, Cortex Phellodendri extract。
(3) respectively by described proportioning weigh step (1) prepare Cortex Phellodendri extract and step (2) prepare Herba Centellae extract, Rhizoma Saururi extract, Flos Hibisci Mutabilis extract, Radix Rhapontici extract, Herba Ixeritis chinensis extract, Folium Mori extract, extract from pine needles, Cortex Phellodendri extract；
(4) Jojoba oil, borage oil, gentamycin sulfate, betamethasone dipropionate, dexmedetomidine, lauryl alcohol sulfuric ester, Borneolum Syntheticum, emulsion stabilizer, preservative, antioxidant are weighed by described proportioning respectively；
(5) require to prepare into topical agent according to pharmacy conventional pharmaceutical method and adjuvant by all the components that above-mentioned steps (3) is got ready with step (4)。
7. a kind of preparation method treating paronychial topical agent as claimed in claim 6, it is characterised in that the dosage form of described topical agent includes: ointment, gel, emplastrum etc.。
CN201610152518.6A 2016-03-16 2016-03-16 External medicament for treating paronychia and preparation method thereof Pending CN105687442A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104771475A (en) * 2015-04-09 2015-07-15 苏州市天灵中药饮片有限公司 Traditional Chinese medicine ointment for treating paronychia and preparation method of traditional Chinese medicine ointment

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104771475A (en) * 2015-04-09 2015-07-15 苏州市天灵中药饮片有限公司 Traditional Chinese medicine ointment for treating paronychia and preparation method of traditional Chinese medicine ointment

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Application publication date: 20160622