CN105663394A - Chinese date healthcare product having effect of enhancing immunity as well as preparation method and application of healthcare product - Google Patents

Chinese date healthcare product having effect of enhancing immunity as well as preparation method and application of healthcare product Download PDF

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Publication number
CN105663394A
CN105663394A CN201610071012.2A CN201610071012A CN105663394A CN 105663394 A CN105663394 A CN 105663394A CN 201610071012 A CN201610071012 A CN 201610071012A CN 105663394 A CN105663394 A CN 105663394A
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parts
preparation
immunity
date
healthcare products
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CN201610071012.2A
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Chinese (zh)
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孙爱华
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725—Ziziphus, e.g. jujube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/55—Liquid-liquid separation; Phase separation

Abstract

The invention belongs to the field of traditional Chinese medicines and discloses a Chinese date healthcare product having an effect of enhancing immunity. The Chinese date healthcare product is prepared from 20 parts of Chinese dates, 20 parts of sarmentose pepper herbs, 18 parts of Cinnamomum japonicum Sieb., 15 parts of veronicastrum herbs, 16 parts of herbs of goldencup St. John's wort, 20 parts of Eupatorium fortune and 6 parts of liquorice roots. The dosage forms include granules, tablets and capsules. The invention further discloses a preparation method comprising the steps as follows: the materials are decocted with water, concentrated and subjected to alcohol precipitation and spray drying, obtained granules are crushed into dry extract powder, auxiliary materials are added, and the required preparation is prepared. The invention further discloses an application of the healthcare product having the effect of enhancing immunity.

Description

A kind of date healthcare products improving immunizing power and its preparation method and application
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, it is specifically related to a kind of date healthcare products improving immunizing power and its preparation method and application.
Background technology
Immunizing power is the defense mechanism of human body self, human bioequivalence and any foreign matter (virus, bacterium etc.) eliminating external intrusion, process is old and feeble, damage, death, the ability of mutant cell and virus infected cell in the own cells of sex change and identification and handling body. Immunology Today is thought, immunizing power is human bioequivalence and the physiological response getting rid of " dissident ". What perform this function in human body is immunity system. Up to now, people are finding the traditional Chinese medicine health care product of a kind of raising immunizing power making simple, easy administration.
Summary of the invention
Goal of the invention: in order to solve the problem, it is an object of the invention to provide a kind of date healthcare products improving immunizing power and its preparation method and application.
Technical scheme: it is an object of the invention to by following scheme realize:
Having the date healthcare products improving efficacy of immunity, the activeconstituents contained by it is prepared from by following raw materials in part by weight proportioning: 20 parts, date, vacation 20 parts, 18 parts, osmanthus, India, Veronicastrum Herb 15 parts, Herba Hyperici Patuli 16 parts, Thickleaf Croton Root 20 parts, 6 parts, Radix Glycyrrhizae.
Described have the date healthcare products improving immunizing power, and preparation method's step is: gets above-mentioned medicinal material and merges, boiling twice, merging decocting liquid, concentrating to relative density when 65 DEG C is 1.10-1.20, adds ethanol, stir, make alcohol content by volume percentage calculation reach 65-85%, leave standstill, filter, filtrate decompression concentrates and is 1.20-1.30 to relative density when 65 DEG C and reclaims ethanol, and by concentrated solution spraying dry, gained particle pulverizes into dry extract, add auxiliary material, make required preparation.
Described have the date healthcare products improving efficacy of immunity, and in preparation method, decocting condition is: amount of water is the 8-12 times amount of medicinal material weight for the first time, decocts and boils 1-2h, and second time amount of water is the 6-10 times amount of medicinal material weight, decocts and boils 1-2h.
Described have the date healthcare products improving efficacy of immunity, and in preparation method, spray drying condition is: inlet temperature is 90-110 DEG C, and air outlet temperature is 60-90 DEG C, and temperature of charge is 60-90 DEG C, and atomizing pressure is 0.2-0.5 MPa, and spray velocity is 1-10ml/s.
Described have the application of the date healthcare products improving efficacy of immunity in preparation raising efficacy of immunity healthcare products.
Above-mentioned Chinese medicine is false, and Latin is called Pipersarmentosum, is the plant of piperaceae Piper. It is distributed in the ground such as Yunnan of India, Vietnam, Indonesia, Philippines, Papua New Guinea, Malaysia and China's Mainland, Guizhou, Fujian, Tibet, Guangdong, Guangxi, it is grown on height above sea level 1, the area of 400 meters, normal growth is on the other wetland of sylvan life and village, in Vietnam, there is artificial growth in Laos.Wen Zhong, promoting the circulation of qi, dispels the wind, detumescence. For with stomach cold pain, inflatable stomachache etc. The present invention is used as medicine with leaf.
Osmanthus, India, Latin is called CinnamomumjaponicumSieb., buttercup order canella, aiphyllium, high 10-15 rice, diameter of a cross-section of a tree trunk 1.3 meters above the ground 30-35 centimetre. Warming spleen and stomach for dispelling cold, regulating QI to relieve pain. For stomachache, stomachache, rheumatic arthritis; Wound is controlled in external application. The present invention is used as medicine with leaf.
Veronicastrum Herb, Classification system Veronicastrumstenostachyum (Hemsl.) Yamazaki is stem leaf or the root of the raw Veronicastrum Herb of goatweed armpit or Veronicastrum Herb. Inducing diuresis to remove edema, loose stasis of blood removing toxic substances. For ascites, oedema, dysuria, menoxenia, amenorrhoea, wound; Parotitis is controlled in external application, furunculosis, burn and scald, venomous snake bite.
Herba Hyperici Patuli is Radix Hyperici Monogyni (Herba Hyperici Monogyni) section hypericum Herba Hyperici Patuli HypericumpatulumThunb., with all herbal medicine. Summer adopts browse, and autumn fruit picking is real, and complete stool can be adopted the whole year, using fresh herb or dry. Clearing heat and detoxicating, cooling blood for hemostasis, kills worm, antipruritic. Full grass: upper respiratory tract infection, hepatitis, dysentery, ephritis. Really: metrorrhagia, nosebleed epistaxis. Leaf: skin pruritus is controlled in external application, impetigo. Root: ascarifuge.
Thickleaf Croton Root is Euphorbiaceae crotons platymiscium Thickleaf Croton Root CrotoncrassifoliusGeisel. [C.chinensisBenth.], is used as medicine with root. Autumn and winter uproot, and clean, and section, dries for subsequent use. Treat for stomachache, flatulence, rheumatic arthralgia, wound, pharyngalgia, stenocardia, snakebite. All the other are pharmacopeia kind.
Useful effect: immunizing power is low is exactly positive QI-insufficiency by traditional Chinese medical science saying. Treatment is not only wanted qi-restoratives righting, also answer promoting the circulation of qi dispel the wind promoting blood circulation and removing blood stasis, clearing heat and detoxicating. Therefore false in we, osmanthus, India promoting the circulation of qi is dispeled the wind as monarch's medicine, and Veronicastrum Herb, Herba Hyperici Patuli, Thickleaf Croton Root is promoting blood circulation and removing blood stasis is ministerial drug, and date, Radix Glycyrrhizae are adjuvant, and all medicines are harmonious, and play benefiting QI for activating blood circulation altogether, for improving immunizing power.
Embodiment
Form by the following examples, the foregoing of the present invention is described in further detail again, but this should not being interpreted as, the scope of the above-mentioned theme of the present invention is only limitted to following example, and all technology realized based on foregoing of the present invention all belong to the scope of the present invention.
Embodiment 1: the preparation of granule
Get date 20g, false 20g, osmanthus, India 18g, Veronicastrum Herb 15g, Herba Hyperici Patuli 16g, Thickleaf Croton Root 20g, Radix Glycyrrhizae 6g medicinal material mixes, boiling twice, add water 8 times amount into medicinal material weight for the first time, decoct and boil 1.5h, add water 6 times amount into medicinal material weight for the second time, decoct and boil 1h, merge decocting liquid, filter, filtrate concentrates to relative density 1.10 (65 DEG C), adding ethanol in proper amount makes alcohol content (volume fraction) reach 65%, stir, leave standstill 24 hours, filter, filtrate recycling ethanol the medicinal extract that concentrates to relative density 1.10 (65 DEG C), it is spray-dried that (condition is inlet temperature is 100 DEG C, air outlet temperature is 80 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s. ), to pulverize into dry extract, then add suitable 50g dextrin, with appropriate 80% ethanol wet, softwood processed, cross 14 order sieves and granulate, 70 DEG C of dryings, the 60 whole grains of order, obtain granule.
Embodiment 2: the preparation of tablet
Get date 20g, false 20g, osmanthus, India 18g, Veronicastrum Herb 15g, Herba Hyperici Patuli 16g, Thickleaf Croton Root 20g, Radix Glycyrrhizae 6g medicinal material mixes, boiling twice, 10 times amount into medicinal material weight that add water, decoct and boil 2h, add water 8 times amount into medicinal material weight for the second time, decoct and boil 1h, merge decocting liquid, filter, filtrate concentrates to relative density 1.15 (65 DEG C), adding ethanol in proper amount makes alcohol content (volume fraction) reach 75%, stir, leave standstill 24 hours, filter, filtrate recycling ethanol the medicinal extract that concentrates to relative density 1.25 (65 DEG C), it is spray-dried that (condition is inlet temperature is 120 DEG C, air outlet temperature is 90 DEG C, temperature of charge is 80 DEG C, atomizing pressure is 0.3 MPa, spray velocity is 7.5/s.), to pulverize into dry extract, then add starch 50g, mix, with appropriate 80% ethanol wet, softwood processed, cross 30 order sieves and granulate, in 70～80 DEG C of dryings, sieve whole grain with 60 orders, compressing tablet, bag fat clothing, packing, outer packaging, censorship is qualified, obtains finished product.
Embodiment 3: the preparation of capsule
Get date 20g, false 20g, osmanthus, India 18g, Veronicastrum Herb 15g, Herba Hyperici Patuli 16g, Thickleaf Croton Root 20g, Radix Glycyrrhizae 6g medicinal material mixes, boiling twice, add water 10 times amount into medicinal material weight for the first time, decoct and boil 1.5h, add water 8 times amount into medicinal material weight for the second time, decoct and boil 1.5h, merge decocting liquid, filter, filtrate concentrates to relative density 1.15 (65 DEG C), adding ethanol in proper amount makes alcohol content (volume fraction) reach 75%, stir, leave standstill 24 hours, filter, filtrate recycling ethanol the medicinal extract that concentrates to relative density 1.25 (65 DEG C), it is spray-dried that (condition is inlet temperature is 120 DEG C, air outlet temperature is 90 DEG C, temperature of charge is 90 DEG C, atomizing pressure is 0.4 MPa, spray velocity is 7.5/s. ), pulverize into dry extract, cross No. 6 sieves, refill into No. 1 capsule finished product.
Embodiment 4: the present invention improves the pharmacodynamic study of immunizing power
Experiment purpose: with this product gavage mouse 30d of different concns, compares the present invention and the normal group mouse difference by the splenic lymphocyte proliferation of ConA induction, judges whether the present invention strengthens splenic lymphocyte proliferation.
Laboratory animal: Kunming mouse, male, body weight 18-22g, Shanghai Si Laike laboratory animal company limited provides, production licence: SCXK (Shanghai) 2007-0005.
Experimental agents: prepare by the preparation method of above-mentioned granule embodiment.
Experimental procedure:
Mouse, by body weight layering random packet, often organizes 12. As shown in the table, normal group gavage feeds water; R-12564 group gavage R-12564; The basic, normal, high dosage group of compound gavage 1,2,4g kg respectively-1Sample of the present invention, the continuous gastric infusion 30d of each group. Aseptic getting spleen, conveniently make individual cells suspension, adjustment cell concn is 5 × 105Individual/mL. Being added in 24 orifice plates by splenocyte suspension, every hole 1mL, every animal establishes two multiple holes, and a hole is normally cultivated (adding 50uLPRMI1640 nutrient solution); One hole adds 50uL concanavalin A (ConA) liquid (final concentration is 4.76ug/mL). It is placed in 5%CO2, 37 DEG C of CO2Incubate and case is cultivated 48h. Experiment terminates front 4h, and every hole sucks supernatant liquor 700uL, then adds 700uL not containing the PRMI1640 nutrient solution of foetal calf serum, and every hole adds the MTT liquid of 50uL5mg/mL simultaneously. After cultivation terminates, every hole adds 1mL acid isopropyl alcohol, and the even crystallization to purple of careful piping and druming is all dissolved. Being dispensed in 96 well culture plates before detection, 4 multiple holes are done in every hole, and at 570nm wavelength, place measures its optical density value.
Experimental result: of the present invention group of mouse spleen lymphocyte is significantly higher than normal group mouse by the proliferation rate conversion values after ConA induction, as shown in the table.
Table 1 the present invention on the impact of spleen lymphocyte proliferation (N=12)
Note: compared with normal group★★P < 0.01,★P < 0.05.
Conclusion: the present invention can strengthen spleen lymphocytic hyperplasia, therefore the present invention can improve immunizing power, can be used for preparation and improves efficacy of immunity healthcare products.

Claims (5)

1. one kind has the date healthcare products improving efficacy of immunity, it is characterized in that, the activeconstituents contained by it is prepared from by following raw materials in part by weight proportioning: 20 parts, date, vacation 20 parts, 18 parts, osmanthus, India, Veronicastrum Herb 15 parts, Herba Hyperici Patuli 16 parts, Thickleaf Croton Root 20 parts, 6 parts, Radix Glycyrrhizae.
2. there are date healthcare products as claimed in claim 1 that improve immunizing power, it is characterized in that, preparation method's step is: gets above-mentioned medicinal material and merges, boiling twice, merge decocting liquid, concentrating to relative density when 65 DEG C is 1.10-1.20, adds ethanol, stirs, make alcohol content by volume percentage calculation reach 65-85%, leaving standstill, filter, filtrate decompression concentrates to relative density when 65 DEG C and is 1.20-1.30 and reclaims ethanol, by concentrated solution spraying dry, gained particle pulverizes into dry extract, adds auxiliary material, makes required preparation.
3. there are date healthcare products as claimed in claim 2 that improve efficacy of immunity, it is characterized in that, in preparation method, decocting condition is: amount of water is the 8-12 times amount of medicinal material weight for the first time, decocts and boils 1-2h, second time amount of water is the 6-10 times amount of medicinal material weight, decocts and boils 1-2h.
4. there are date healthcare products as claimed in claim 2 that improve efficacy of immunity, it is characterized in that, in preparation method, spray drying condition is: inlet temperature is 90-110 DEG C, air outlet temperature is 60-90 DEG C, temperature of charge is 60-90 DEG C, atomizing pressure is 0.2-0.5 MPa, and spray velocity is 1-10ml/s.
5. there are date healthcare products as claimed in claim 1 that improve efficacy of immunity in the application improved in efficacy of immunity healthcare products.
CN201610071012.2A 2016-02-01 2016-02-01 Chinese date healthcare product having effect of enhancing immunity as well as preparation method and application of healthcare product Withdrawn CN105663394A (en)

Priority Applications (1)

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CN201610071012.2A CN105663394A (en) 2016-02-01 2016-02-01 Chinese date healthcare product having effect of enhancing immunity as well as preparation method and application of healthcare product

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101612337A (en) * 2009-07-17 2009-12-30 邵梦扬 The Chinese medicine health care product of enhancing immunity
CN102172383A (en) * 2011-01-12 2011-09-07 涂传荣 Chinese medicinal preparation having functions of enhancing immunity, promoting digestion and improving sleep
CN102465073A (en) * 2010-11-05 2012-05-23 威海紫光科技园有限公司 Fig health care wine and preparation method thereof
CN102578576A (en) * 2012-02-27 2012-07-18 苏州爱斯欧蒂生物科技有限公司 Multi-effect weight-losing health-care product
CN102614280A (en) * 2012-04-23 2012-08-01 卞毓平 Chinese medicinal composition with blood fat reducing effect, and preparation method and application thereof
CN103800661A (en) * 2014-01-10 2014-05-21 北京同仁堂健康药业股份有限公司 Composition for improving immunity and relieving physical fatigue and preparation thereof

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Publication number Priority date Publication date Assignee Title
CN101612337A (en) * 2009-07-17 2009-12-30 邵梦扬 The Chinese medicine health care product of enhancing immunity
CN102465073A (en) * 2010-11-05 2012-05-23 威海紫光科技园有限公司 Fig health care wine and preparation method thereof
CN102172383A (en) * 2011-01-12 2011-09-07 涂传荣 Chinese medicinal preparation having functions of enhancing immunity, promoting digestion and improving sleep
CN102578576A (en) * 2012-02-27 2012-07-18 苏州爱斯欧蒂生物科技有限公司 Multi-effect weight-losing health-care product
CN102614280A (en) * 2012-04-23 2012-08-01 卞毓平 Chinese medicinal composition with blood fat reducing effect, and preparation method and application thereof
CN103800661A (en) * 2014-01-10 2014-05-21 北京同仁堂健康药业股份有限公司 Composition for improving immunity and relieving physical fatigue and preparation thereof

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Application publication date: 20160615