CN105663393A - Traditional Chinese medicine composition for treating liver diseases - Google Patents
Traditional Chinese medicine composition for treating liver diseases Download PDFInfo
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- CN105663393A CN105663393A CN201610157003.5A CN201610157003A CN105663393A CN 105663393 A CN105663393 A CN 105663393A CN 201610157003 A CN201610157003 A CN 201610157003A CN 105663393 A CN105663393 A CN 105663393A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/68—Plantaginaceae (Plantain Family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention provides a traditional Chinese medicine composition for treating liver diseases. The traditional Chinese medicine composition is prepared from, by weight, 14-16 parts of herba artemisiae scopariae, 9-11 parts of plantain herb, 4-6 parts of medicated leaven, 4-6 parts of Chinese magnoliavine fruits, 4-6 parts of honeysuckle flowers, 4-6 parts of common scouring rush herb and 4-6 parts of Korean ginseng. The traditional Chinese medicine composition can effectively treat hepatitis B, hepatitis C, cirrhosis, hepatic fibrosis, liver cancer and the like, and is short in treatment cycle, fast in effect taking and free of toxic or side effects.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine composition treating hepatopathy.
Background technology
Hepatopathy refers to and the pathological changes at liver, the multiple disease such as including hepatitis A, hepatitis B, hepatitis C, liver cirrhosis, hepatic fibrosis, alcoholic liver, hepatocarcinoma occurs. Hepatopathy is one of principal disease threatening human health now.
Chronic hepatitis B, be called for short hepatitis B, refer to hepatitis B virus test positive, the course of disease exceed half a year or date of the onset is indefinite and clinic has chronic hepatitis shower. The symptoms such as clinical manifestation is weak, sitophobia, feel sick, abdominal distention, hepatalgia. Hepatomegaly, quality is medium hardness, has light tenderness. State of an illness severe one can with chronic hepatopathy face, spider angioma, liver palm, splenomegaly, liver function can exception or persistent anomaly, be divided into slightly according to clinical manifestation, moderate and severe. Data shows according to investigations, whole nation hepatitis B virus surface antigen carrying rate on average about 7.18%, and hepatitis B preventing and treating has become as one of great public health problem of China.
Hepatitis C, referred to as hepatitis C, it it is a kind of viral hepatitis being infected by hepatitis C virus (HCV) and causing, propagate mainly through blood transfusion, acupuncture, drug abuse etc., add up according to World Health Organization (WHO), the infection rate of whole world HCV is about 3%, estimates that about 1.8 hundred million people have infected HCV, annual new hepatitis C case about 3.5 ten thousand example. Hepatitis C is global prevalence, may result in the necrosis of liver chronic inflammatory disease and fibrosis, and some patients can develop into liver cirrhosis even hepatocarcinoma (HCC). Continuation is increased by mortality rate (death that liver failure and hepatocarcinoma cause) relevant to HCV infection in following 20 years, and the health and lives of patient is very harmful.
The way of current hepatopathy many employings combination of Chinese and Western medicine is treated, but there is following defect: the somewhat expensive of western medicine, and treatment time is long, and side effect is big; Current Chinese medicine preparation prescription is complicated, and therapeutic effect is unstable, weak curative effect etc.
Hepatopathy sickness rate height, course of disease length, easily recur, if malpractice can cause the delay of the course of disease, it is therefore desirable to research and develop the medicine of new treatment hepatopathy, to improve therapeutic effect.
Summary of the invention
It is an object of the invention to for the deficiencies in the prior art, a kind of Chinese medicine composition treating hepatopathy is provided, can the disease such as fast treating hepatitis B, hepatitis C, liver cirrhosis, hepatocarcinoma, recover liver function, there is the features such as therapeutic effect is notable, treatment cycle is short, have no side effect.
The invention provides a kind of Chinese medicine composition treating hepatopathy, be made up of the crude drug of following weight portion:
Herba Artemisiae Scopariae 14-16 part, Herba Plantaginis 9-11 part, Massa Medicata Fermentata 4-6 part, Fructus Schisandrae Chinensis 4-6 part, Flos Lonicerae 4-6 part, Herba Equiseti Hiemalis's 4-6 part, Korean Ginseng 4-6 part.
Preferably, the Chinese medicine composition of described treatment hepatopathy is made up of the crude drug of following weight portion:
Herba Artemisiae Scopariae 15 parts, Herba Plantaginis 10 parts, Massa Medicata Fermentata 5 parts, Fructus Schisandrae Chinensis 5 parts, Flos Lonicerae 5 parts, Herba Equiseti Hiemalis 5 parts, Korean Ginseng 5 parts.
Chinese medicine composition according to the present invention can be used for treating hepatopathy, and described hepatopathy includes hepatitis B, hepatitis C, liver cirrhosis, hepatic fibrosis, hepatocarcinoma etc.
A kind of method that present invention also offers Chinese medicine composition preparing described treatment hepatopathy, including:
(1) raw material of Chinese medicine is prepared by weight;
(2) by Korean Ginseng with cold water soak 20-30 hour;
(3) Korean Ginseng soaked and other raw materials being added cold water to decoct, water continues to decoct 15-17 minute after opening, filtering liquid medicine, then adds cold water for the second time and decocts, and water continues to decoct 15-17 minute after opening, filtering liquid medicine;
(4) medicinal liquid after twice filtration is merged, obtain described Chinese medicine composition.
Preferably, the method according to the Chinese medicine composition preparing described treatment hepatopathy of the present invention, including:
(1) press row weight portion and prepare raw material of Chinese medicine;
Herba Artemisiae Scopariae 15 parts, Herba Plantaginis 10 parts, Massa Medicata Fermentata 5 parts, Fructus Schisandrae Chinensis 5 parts, Flos Lonicerae 5 parts, Herba Equiseti Hiemalis 5 parts, Korean Ginseng 5 parts;
(2) by Korean Ginseng cold water soak 24 hours;
(3) Korean Ginseng soaked and other raw materials being added cold water to decoct, water continues to decoct 16 minutes after opening, filtering liquid medicine; Then second time adds cold water decoction, and water continues to decoct 16 minutes after opening, filtering liquid medicine;
(4) medicinal liquid after twice filtration is merged, obtain described Chinese medicine composition.
Wherein, the amount of water of each boiling is 10-15 times of raw material of Chinese medicine weight, it is preferable that 13 times. The water wherein soaking Korean Ginseng is used as decoction water.
In decoction process, control decocting time extremely important. Add cold water to decoct every time, after water is opened, continue to decoct 15-17 minute. If decocting time was less than 15 minutes, it is impossible to fully extract raw material the effective elements of the medicine; If decocting time was more than 17 minutes, drug effect can decline, and affects therapeutic effect. Preferably, after water is opened, continue to decoct 15-16 minute, more preferably 16 minutes.
Present invention also offers a kind of oral formulations being made up of the Chinese medicine composition of above-mentioned treatment hepatopathy, can by above-mentioned Chinese medicine composition and medically receivable adjuvant form. Described oral formulations includes oral liquid, tablet, capsule, pill etc., it is preferable that dosage form is oral liquid.
The Chinese medicine composition of the present invention can be prepared as multiple dosage form. Such as, by pack after the medicinal liquid sterilizing after decoction, oral liquid is made; Or the medicinal liquid after decocting is concentrated, after drying, adds medically receivable adjuvant, then make tablet, capsule, pill etc.
Described medically receivable adjuvant includes starch, dextrin, sodium carboxymethyl cellulose, Polyethylene Glycol, calcium hydrogen phosphate, sodium alginate, potassium sorbate etc.
The Chinese medicine composition of the present invention is with two months for a course for the treatment of, and every day takes night and morning.
Chinese medicine composition according to the present invention can effectively treat the diseases such as hepatitis B, hepatitis C, liver cirrhosis, hepatocarcinoma, recovers liver function, and therapeutic effect is good, has no side effect.
The oral liquid that Chinese medicine composition according to the present invention is made, good stability, bioavailability is high, and treatment cycle is short, instant effect, and cure rate is high.
Detailed description of the invention
Below in conjunction with embodiment, the Chinese medicine composition of the treatment hepatopathy of the present invention is elaborated. It will be obvious to those skilled in the art that following preferred embodiment is merely cited for, and it is not construed as limiting the invention.
One, the preparation of Chinese medicine composition
Embodiment 1
(1) raw material of Chinese medicine of following weight portion is taken
Herba Artemisiae Scopariae 15 grams, Herba Plantaginis 10 grams, Massa Medicata Fermentata 5 grams, Fructus Schisandrae Chinensis 5 grams, Flos Lonicerae 5 grams, Herba Equiseti Hiemalis 5 grams, Korean Ginseng 5 grams;
(2) by Korean Ginseng cold water soak 24 hours;
(3) Korean Ginseng soaked and other raw materials being added the decoction of 650 milliliters of cold water, water continues to decoct 16 minutes after opening, filtering liquid medicine; Then second time adds water 650 milliliters and decocts, and water continues to decoct 16 minutes after opening, filtering liquid medicine;
Wherein, the water soaking Korean Ginseng is used as decoction water;
(4) medicinal liquid after twice filtration is merged, obtain oral liquid.
Embodiment 2
(1) raw material of Chinese medicine of following weight portion is taken
Herba Artemisiae Scopariae 16 grams, Herba Plantaginis 11 grams, Massa Medicata Fermentata 5 grams, Fructus Schisandrae Chinensis 5 grams, Flos Lonicerae 5 grams, Herba Equiseti Hiemalis 5 grams, Korean Ginseng 5 grams;
(2) by Korean Ginseng cold water soak 24 hours;
(3) Korean Ginseng soaked and other raw materials being added water 680 milliliters and decoct, water continues to decoct 16 minutes after opening, filtering liquid medicine, and then second time adds water 680 milliliters and decocts, and water continues to decoct 16 minutes after opening, filtering liquid medicine;
Wherein, the water soaking Korean Ginseng is used as decoction water;
(4) medicinal liquid after twice filtration is merged, obtain oral liquid.
Embodiment 3
(1) raw material of Chinese medicine of following weight portion is taken
Herba Artemisiae Scopariae 14 grams, Herba Plantaginis 10 grams, Massa Medicata Fermentata 4 grams, Fructus Schisandrae Chinensis 4 grams, Flos Lonicerae 4 grams, Herba Equiseti Hiemalis 5 grams, Korean Ginseng 5 grams;
(2) by Korean Ginseng cold water soak 24 hours;
(3) 600ml that the Korean Ginseng soaked and other raw materials added water decocts, and water continues to decoct 15 minutes after opening, filtering liquid medicine; Then the 600ml that adds water for the second time decocts, and water continues to decoct 15 minutes after opening, filtering liquid medicine;
Wherein, the water soaking Korean Ginseng is used as decoction water;
(4) medicinal liquid after twice filtration is merged, obtain oral liquid.
The oral liquid obtained in embodiment 1-3 can directly be taken, or adds adjuvant medically, for instance potassium sorbate, then uses sack subpackage, 260 milliliters every bag.
The preparation of the present invention is not limited to above-mentioned oral liquid, it is possible to make other dosage forms, for instance, the medicinal liquid after decocting is concentrated, after drying, adds medically receivable adjuvant, then make tablet, capsule, pill etc.
Two, test examples
For further illustrating the effect of the Chinese medicine composition of the present invention, utilize the embodiment 1-3 oral liquid prepared that hepatopath is treated.
Application method
With two months for a course for the treatment of, every day respectively takes oral liquid once sooner or later, each 260 milliliters.
Evaluation criteria
Cure: clinical symptoms is wholly absent.
Effective: clinical symptoms substantially alleviates.
Invalid: clinical symptoms is substantially free of change.
1, the therapeutic effect to hepatitis B patient
Random choose hepatitis B patient 57 example, the age is in 15-60 year.
Take one course for the treatment of of oral liquid of embodiment 1 preparation. To the therapeutic effect of hepatitis B patient in Table 1.
Table 1
| Number of cases | Cure | Effectively | Invalid | Cure rate | Effective percentage |
| 57 | 53 | 4 | 0 | 92.9% | 100% |
2, the therapeutic effect to hepatitis C patient
Random choose hepatitis C patient 23 example, the age is in 18-53 year.
Take one course for the treatment of of oral liquid of embodiment 2 preparation. To the therapeutic effect of hepatitis C patient in Table 2.
Table 2
| Number of cases | Cure | Effectively | Invalid | Cure rate | Effective percentage |
| 23 | 21 | 2 | 0 | 91.3% | 100% |
3, the therapeutic effect to the third cancer patient
Temperature certain, female, 36 years old, people from Ganzhou, have a liver complaint the several years, hospital finds suffers from hepatocarcinoma. Taking the oral liquid of the embodiment of the present invention 3 preparation after 1 year, hospital's check hepatic region is substantially at health status. After continuing to take half a year, recover normal.
It is shown that hepatitis B, hepatitis C and hepatocarcinoma are had significant curative effect by the Chinese medicine composition according to the present invention, treatment cycle is short, cure rate is high, does not find toxic and side effects in clinic.
Claims (8)
1. treat a Chinese medicine composition for hepatopathy, be made up of the crude drug of following weight portion:
Herba Artemisiae Scopariae 14-16 part, Herba Plantaginis 9-11 part, Massa Medicata Fermentata 4-6 part, Fructus Schisandrae Chinensis 4-6 part, Flos Lonicerae 4-6 part, Herba Equiseti Hiemalis's 4-6 part, Korean Ginseng 4-6 part.
2. the Chinese medicine composition for the treatment of hepatopathy according to claim 1, is made up of the crude drug of following weight portion:
Herba Artemisiae Scopariae 15 parts, Herba Plantaginis 10 parts, Massa Medicata Fermentata 5 parts, Fructus Schisandrae Chinensis 5 parts, Flos Lonicerae 5 parts, Herba Equiseti Hiemalis 5 parts, Korean Ginseng 5 parts.
3. the Chinese medicine composition for the treatment of hepatopathy according to claim 1 and 2, wherein, described hepatopathy includes hepatitis B, hepatitis C, liver cirrhosis, hepatic fibrosis, hepatocarcinoma.
4. a preparation method for the Chinese medicine composition of the treatment hepatopathy described in claim 1, including:
(1) raw material of Chinese medicine is prepared by weight;
(2) by Korean Ginseng with cold water soak 20-30 hour;
(3) Korean Ginseng soaked and other raw materials being added cold water to decoct, water continues to decoct 15-17 minute after opening, filtering liquid medicine, then adds cold water for the second time and decocts, and water continues to decoct 15-17 minute after opening, filtering liquid medicine;
(4) medicinal liquid after twice filtration is merged, obtain described Chinese medicine composition.
5. preparation method according to claim 4, including:
(1) press row weight portion and prepare raw material of Chinese medicine;
Herba Artemisiae Scopariae 15 parts, Herba Plantaginis 10 parts, Massa Medicata Fermentata 5 parts, Fructus Schisandrae Chinensis 5 parts, Flos Lonicerae 5 parts, Herba Equiseti Hiemalis 5 parts, Korean Ginseng 5 parts;
(2) by Korean Ginseng cold water soak 24 hours;
(3) Korean Ginseng soaked and other raw materials being added cold water to decoct, water continues to decoct 16 minutes after opening, filtering liquid medicine; Then second time adds cold water decoction, and water continues to decoct 16 minutes after opening, filtering liquid medicine;
(4) medicinal liquid after twice filtration is merged, obtain described Chinese medicine composition.
6. the preparation method according to claim 4 or 5, wherein, the amount of water of each boiling is 10-15 times of raw material of Chinese medicine weight, it is preferable that 13 times.
7. Chinese medicine composition prepared any one of an oral formulations, Chinese medicine composition according to any one of claim 1-3 or claim 4-6 is made.
8. oral formulations according to claim 7, including oral liquid, tablet, capsule, pill, it is preferable that oral liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610157003.5A CN105663393A (en) | 2016-03-18 | 2016-03-18 | Traditional Chinese medicine composition for treating liver diseases |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610157003.5A CN105663393A (en) | 2016-03-18 | 2016-03-18 | Traditional Chinese medicine composition for treating liver diseases |
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| CN201610157003.5A Pending CN105663393A (en) | 2016-03-18 | 2016-03-18 | Traditional Chinese medicine composition for treating liver diseases |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1105581A (en) * | 1994-01-17 | 1995-07-26 | 江洋 | Yinhuang Ganfu powder for curing hepatitis |
| CN101612360A (en) * | 2009-07-17 | 2009-12-30 | 肖嘉惠 | The medicine of treatment hepatitis, liver cirrhosis, hepatocarcinoma |
| CN102120008A (en) * | 2011-02-21 | 2011-07-13 | 蔺洪俊 | Traditional Chinese medicine for treating icteric hepatitis |
| CN104758717A (en) * | 2015-03-17 | 2015-07-08 | 朱克兰 | Traditional Chinese medicine composition for treating chronic hepatitis |
-
2016
- 2016-03-18 CN CN201610157003.5A patent/CN105663393A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1105581A (en) * | 1994-01-17 | 1995-07-26 | 江洋 | Yinhuang Ganfu powder for curing hepatitis |
| CN101612360A (en) * | 2009-07-17 | 2009-12-30 | 肖嘉惠 | The medicine of treatment hepatitis, liver cirrhosis, hepatocarcinoma |
| CN102120008A (en) * | 2011-02-21 | 2011-07-13 | 蔺洪俊 | Traditional Chinese medicine for treating icteric hepatitis |
| CN104758717A (en) * | 2015-03-17 | 2015-07-08 | 朱克兰 | Traditional Chinese medicine composition for treating chronic hepatitis |
Non-Patent Citations (2)
| Title |
|---|
| 郭国华: "《临床中医药辞典》", 30 September 1994, 湖南科学技术出版社 * |
| 陈志东: "《润肺益气 食疗便典》", 31 July 2008, 广东世界图书出版公司 * |
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Application publication date: 20160615 |
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