CN105659087B - 筛选靶向靶生物实体的候选生物实体的方法 - Google Patents
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- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361834782P | 2013-06-13 | 2013-06-13 | |
| US61/834,782 | 2013-06-13 | ||
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Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9182406B2 (en) | 2008-08-04 | 2015-11-10 | Biodesy, Inc. | Nonlinear optical detection of molecules comprising an unnatural amino acid possessing a hyperpolarizability |
| CA2831136A1 (en) | 2011-03-21 | 2012-09-27 | Biodesy, Llc | Classification of kinase inhibitors using nonlinear optical techniques |
| US9395358B2 (en) | 2012-02-05 | 2016-07-19 | Biodesy, Inc. | Methods for detecting allosteric modulators of protein |
| US20130288271A1 (en) | 2012-04-25 | 2013-10-31 | Biodesy, Llc | Methods for detecting allosteric modulators of protein |
| WO2013115867A1 (en) | 2012-02-05 | 2013-08-08 | Biodesy, Llc | Methods for identifying modulators of ras using nonlinear techniques |
| US9227978B2 (en) | 2013-03-15 | 2016-01-05 | Araxes Pharma Llc | Covalent inhibitors of Kras G12C |
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| EP3161168B1 (en) | 2014-06-30 | 2021-08-04 | Bluelight Therapeutics, Inc. | Systems and methods for high throughput analysis of conformation in biological entities |
| JO3556B1 (ar) | 2014-09-18 | 2020-07-05 | Araxes Pharma Llc | علاجات مدمجة لمعالجة السرطان |
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| WO2016049524A1 (en) | 2014-09-25 | 2016-03-31 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
| EP3237906B8 (en) | 2014-12-23 | 2020-10-28 | Bluelight Therapeutics, Inc. | Attachment of proteins to interfaces for use in nonlinear optical detection |
| CN107615047A (zh) | 2015-04-02 | 2018-01-19 | 比奥德赛公司 | 利用表面选择性非线性光学技术确定蛋白质结构的方法 |
| EA201792214A1 (ru) | 2015-04-10 | 2018-01-31 | Араксис Фарма Ллк | Соединения замещенного хиназолина |
| EP3283462B1 (en) | 2015-04-15 | 2020-12-02 | Araxes Pharma LLC | Fused-tricyclic inhibitors of kras and methods of use thereof |
| US10144724B2 (en) | 2015-07-22 | 2018-12-04 | Araxes Pharma Llc | Substituted quinazoline compounds and methods of use thereof |
| WO2017053567A1 (en) * | 2015-09-22 | 2017-03-30 | Delta Tm Technologies | Designing customized protein-specific buffer systems |
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| JP2018533939A (ja) | 2015-10-19 | 2018-11-22 | アラクセス ファーマ エルエルシー | Rasの阻害剤をスクリーニングするための方法 |
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| WO2018140599A1 (en) | 2017-01-26 | 2018-08-02 | Araxes Pharma Llc | Benzothiophene and benzothiazole compounds and methods of use thereof |
| WO2018195134A1 (en) * | 2017-04-18 | 2018-10-25 | X-Chem, Inc. | Methods for identifying compounds |
| JP2020521740A (ja) | 2017-05-25 | 2020-07-27 | アラクセス ファーマ エルエルシー | 変異体kras、hrasまたはnrasの調節因子としてのキナゾリン誘導体 |
| WO2018218071A1 (en) | 2017-05-25 | 2018-11-29 | Araxes Pharma Llc | Compounds and methods of use thereof for treatment of cancer |
| TW201900633A (zh) | 2017-05-25 | 2019-01-01 | 美商亞瑞克西斯製藥公司 | Kras之共價抑制劑 |
| US10657525B2 (en) | 2017-06-27 | 2020-05-19 | Kasisto, Inc. | Method and apparatus for determining expense category distance between transactions via transaction signatures |
| US12134620B2 (en) | 2018-08-01 | 2024-11-05 | Araxes Pharma Llc | Heterocyclic spiro compounds and methods of use thereof for the treatment of cancer |
| US20230236170A1 (en) * | 2019-10-15 | 2023-07-27 | Jnana Therapeutics Inc. | Reactive affinity probe-interaction discovery platform |
| CN112630444B (zh) * | 2020-12-11 | 2024-05-24 | 深圳碳云智肽药物科技有限公司 | 基于靶点蛋白的多肽筛选方法 |
| CN113963745A (zh) * | 2021-12-07 | 2022-01-21 | 国际竹藤中心 | 一种构建植物发育分子调控网络的方法及其应用 |
| CN114317669A (zh) * | 2022-01-04 | 2022-04-12 | 北京大学 | 一种基于细胞内蛋白激酶c激活状态筛选药物的方法及高通量筛选装置 |
| WO2024129721A1 (en) * | 2022-12-13 | 2024-06-20 | Lafond David | Systems and methods to predict biological receptor signal response |
Family Cites Families (19)
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| CA2414572A1 (en) * | 2000-07-12 | 2002-01-17 | Karo Bio Usa, Inc. | Method of identifying conformation-sensitive binding peptides and uses thereof |
| US20020094528A1 (en) * | 2000-11-29 | 2002-07-18 | Salafsky Joshua S. | Method and apparatus using a surface-selective nonlinear optical technique for detection of probe-target interations |
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| US7384773B1 (en) | 2001-05-10 | 2008-06-10 | Pfizer Inc | Crystal of HIV protease-cleaved human beta secretase and method for crystallization thereof |
| GB0117326D0 (en) * | 2001-07-16 | 2001-09-05 | Univ Aberdeen | Napthoquinone-type inhibitors of protein aggregation |
| US20030148391A1 (en) * | 2002-01-24 | 2003-08-07 | Salafsky Joshua S. | Method using a nonlinear optical technique for detection of interactions involving a conformational change |
| US7358331B2 (en) * | 2003-05-19 | 2008-04-15 | Elan Pharmaceuticals, Inc. | Truncated fragments of alpha-synuclein in Lewy body disease |
| US7342093B2 (en) * | 2004-07-23 | 2008-03-11 | University Of Massachusetts | Compounds that inhibit Hsp90 protein-protein interactions with IAP proteins |
| EP1637885A1 (en) | 2004-09-16 | 2006-03-22 | Vivalis | Method of screening by using conformation sensitive peptides |
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| AU2007277186B2 (en) * | 2006-07-28 | 2014-01-30 | Presympto, Inc. | Peptide probes for diagnostics and therapeutics |
| EP2326728A1 (en) * | 2008-07-24 | 2011-06-01 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Fluorescently or spin-labeled kinases for rapid screening and identification of novel kinase inhibitor scaffolds |
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| CN106290917B (zh) * | 2012-04-25 | 2020-06-05 | 比奥德赛公司 | 用于检测蛋白质的变构调节剂的方法 |
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