CN105641661A - 一种用于治疗外耳道炎的中药制剂及制备方法 - Google Patents
一种用于治疗外耳道炎的中药制剂及制备方法 Download PDFInfo
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Abstract
本发明公开了一种用于治疗外耳道炎的中药制剂及制备方法,属中药领域;本发明中药制剂有效成分的原料组成为:磨盘根、苘麻、斑鸠菊、球兰、狗牙贝、岩葱、老龙皮、黄菀、驱风通、衰草、胜红蓟、角蒿、武靴藤、蘘荷、虱草花和蜂胶;本发明中药制剂所选药材配伍相宜,具有清热利湿、活血润肌、消肿止痒、止痛止血、排脓消炎的功效,对于因外耳道炎引起的耳廓痛、外耳道疼痛、外耳道狭窄、血性耳漏、耳前淋巴结肿大、易哭、挖耳出血、耳流脓、耳痒、双耳廓缺损等症状的改善及治疗具有显著效果,疗效短,见效快,安全方便,无毒副作用,可广泛应用于外耳道炎的临床治疗。
Description
所属技术领域
本发明涉及中药领域,尤其涉及一种用于治疗外耳道炎的中药制剂及制备方法。
背景技术
外耳道炎可分为两类,一类为局限性外耳道炎,又称外耳道疖;另一类为外耳道皮肤的弥漫性炎症,又称弥漫性外耳道炎。
弥漫性外耳道炎可分为急、慢性两类。急性者轻度表现为轻度耳痛,重者患耳剧痛,咀嚼时加重并可伴耳鸣和听力下降,可流出分泌物。慢性者耳发痒,少量渗出物。外耳道皮肤增厚、皲裂、脱屑,分泌物积存,甚至可造成外耳道狭窄。
急性外耳道炎如治疗不及时或不得当会转为慢性。一旦急性外耳道炎迁延为慢性外耳道炎,则耳部常有不适和痒感,并有少量分泌物,听力稍减退,外耳道皮肤充血或增厚,或覆有痂皮且痂皮上有少量脓液或碎屑、有时揭去痂皮可致出血,外耳鼓膜可浑浊、增厚,标志不清,或因鼓膜上皮受损,其表面有少量肉芽形成。外耳道炎可引起听力下降,产生传导性耳聋及耳鸣,由于外耳道炎分泌无刺激,屏间切迹或耳垂亦可受累。重者耳周淋巴结肿。外耳道炎易反复发作,其常见致病菌为金黄色葡萄球菌链球菌、绿脓杆菌和变形杆菌等。因此,当外耳道有不适(如灼热、疼痛)和痒感,并有少量分泌物时,应及时到医院求治,以免更大疾病的发生。
中药和食物一样是来源于大自然的矿物、植物、动物药,没有毒副作用,中药没有抗药性,可以持续运用直到根治疾病,因此,我们需要研发一种中药来治疗失眠。
发明内容
本发明提供了一种用于治疗外耳道炎的中药制剂及制备方法;本发明中药制剂所选药材配伍相宜,具有清热利湿、活血润肌、消肿止痒、止痛止血、排脓消炎的功效,对于因外耳道炎引起的耳廓痛、外耳道疼痛、外耳道狭窄、血性耳漏、耳前淋巴结肿大、易哭、挖耳出血、耳流脓、耳痒、双耳廓缺损等症状的改善及治疗具有显著效果,疗效短,见效快,安全方便,无毒副作用,可广泛应用于外耳道炎的临床治疗。
为实现上述目的,本发明的技术方案实施如下:
一种用于治疗外耳道炎的中药制剂,制成所述中药制剂有效成分的原料组成及重量份数为:
制成所述中药制剂有效成分的原料组成及重量份数为:
制成所述中药制剂有效成分的原料组成及重量份数为:
制成所述中药制剂有效成分的原料组成及重量份数为:
一种用于治疗外耳道炎的中药制剂的制备方法,包括以下工艺步骤:
(1)将磨盘根、苘麻、斑鸠菊、狗牙贝、岩葱、老龙皮、黄菀、驱风通、蓑草、角蒿、武靴藤和虱草花放入容器中,首先加入10-15倍量蒸馏水浸泡4-5小时后,加热煮沸3-4小时,提取;第二次加8-10倍量蒸馏水加热煮沸2-3小时,提取;第三次加6-8倍量蒸馏水加热煮沸1-2小时,提取;合并提取液,滤过,得滤液备用;
(2)取球兰绞汁,滤杂质,留汁液,备用;
(3)将胜红蓟和蘘荷微波烘干,研末,过160目细粉,备用;
(4)取蜂胶浸入体积浓度为90%酒精溶液,静置4小时,取出上层清液,沉淀下来的浸膏备用;
(5)将步骤(1)-步骤(4)制得的滤液、汁液、细粉和浸膏混合,制成片剂,即为本发明所述的用于治疗外耳道炎的中药制剂。
本发明所用中药的药性如下:
磨盘根:味甘、淡,性平;归肾、脾、肺、膀胱经。清热利湿,通窍活血。主肺燥咳嗽,胃痛,腹痛,泄泻,淋证,疝气,跌打损伤,耳鸣耳聋。《陆川本草》载:“利水,去膀胱湿热。治耳鸣,耳聋,消浊,痔疮。”
苘麻:味苦,性平;归脾、胃经。清热利湿,解毒开窍。主痢疾,中耳炎,耳鸣,耳聋,睾丸炎,化脓性扁桃体炎,痈疽肿毒。《上海常用中草药》载:“全草:解毒,祛风。治痢疾,中耳炎,耳鸣,耳聋,关节酸痛。”
斑鸠菊:味甘、涩,性凉。清热解毒,生肌敛疮。主阑尾炎,疮疖,烫火伤。《云南药用植物名录》载:“用于阑尾炎、疮疖。叶:治疗烫火伤。”
球兰:味苦,性寒;小毒;归肺、心、肝经。清热化痰,消肿止痛,通经下乳。主流行性乙型脑炎,肺热咳嗽,痈肿,乳妇奶少,关节疼痛,睾丸炎,中耳炎,乳腺炎,瘰疬,产妇乳汁少,乳络不通。《福建民间草药》载:“祛风湿,清肝热,消痈肿。”
狗牙贝:味甘、微苦,性平。润肺止咳,祛痰,消炎,止血。治咳嗽,哮喘,肺炎,支气管炎,痈肿疮毒,外伤出血。
岩葱:味辛、微苦,性凉;归肾、膀胱经。清热解毒,散瘀止血。主支气管炎,肺炎,肝炎,尿路感染,中耳炎,疮痈,骨折,外伤出血。
老龙皮:味淡,微苦,性平;归脾、肾经。消食健脾,利水消肿,祛风止痒。主消化不良,小儿疳积,腹胀,水肿,皮肤瘙痒,无名肿毒。
黄菀:味苦、辛,性寒。清热解毒。主痢疾,肠炎,肝炎,结膜炎,中耳炎,痈疗毒。
驱风通:味辛、苦,性温。祛除风湿,消肿解毒,止痛止血。主风寒感冒,风湿痹痛,跌打骨折;外伤出血,烧烫伤,毒蛇咬伤。
衰草:味甘、淡,性凉。清热解毒,凉血散瘀。主感冒,小儿肺炎,肺痨咯血,衄血,尿血,经行不畅,热淋,乳腺炎,荨麻疹,外伤出血。
胜红蓟:味辛、微苦,性凉。清热解毒,止血,止痛。主感冒发热,咽喉肿痛,口舌生疮,咯血,衄血,崩漏,脘腹痛疼痛,跌打损伤,外伤出血,痈肿疮毒,湿疹瘙痒。
角蒿:味苦、甘,性温。调经活血,祛风湿,消炎利耳,益脉。用于中耳炎,根用于虚弱,头晕,胸闷,腹胀,咳嗽,月经不调;叶用于咳嗽。《黑龙江常用中草药手册》载:“治干湿皮疹,阴道滴虫病,疥疮,齿龈腐烂及耳疮,烧灰涂擦。月经不调、风湿痹痛、筋骨疼痛,煎汤熏洗。”
武靴藤:味平,性苦;归心、肝、脾经。清热凉血,排脓消肿,止痛生肌。主风湿痹痛,咽喉肿痛,瘰疬,乳痈,疮疖,湿疹,无名肿毒,毒蛇咬伤。《常用中草药彩色图谱》载:“嫩枝叶,止痛,生肌,消肿。治枪弹伤。杀虱。”
蘘荷:味辛,性温;归肺、肝经。活血调经,祛谈止咳,解毒消肿。主月经不调,痛经,跌打损伤,咳嗽气喘,痈疽肿毒,瘰疬。《贵州民间方药集》载:“通经活血,又可镇咳祛痰。外用可拔毒,消疮肿。”
虱草花:味苦,性寒。清热除蒸,凉血解毒。主肺痨咳嗽,骨蒸劳热,痈疽肿毒,丹毒,风疹瘙痒。
蜂胶:味微甘,性平;归肝、脾经。润肤生肌,消炎止痛。主胃溃疡,口腔溃疡,宫颈糜烂,带状疱疹,牛皮屑,银屑病,皮肤裂痛,鸡眼,烧烫伤。江西《中草药学》载:“保护肉芽组织,利于伤口愈合,对皲裂亦有疗效。”
本发明与现有技术相比,具有以下有益效果:
本发明中药制剂所选药材配伍相宜,具有清热利湿、活血润肌、消肿止痒、止痛止血、排脓消炎的功效,对于因外耳道炎引起的耳廓痛、外耳道疼痛、外耳道狭窄、血性耳漏、耳前淋巴结肿大、易哭、挖耳出血、耳流脓、耳痒、双耳廓缺损等症状的改善及治疗具有显著效果,疗效短,见效快,安全方便,无毒副作用,可广泛应用于外耳道炎的临床治疗。
具体实施方式
下面结合具体实施例对本发明做进一步阐述。
实施例1
本发明中药制剂有效成分的原料组成及重量为:
本发明中药制剂制备方法的工艺步骤为:
(1)将磨盘根、苘麻、斑鸠菊、狗牙贝、岩葱、老龙皮、黄菀、驱风通、蓑草、角蒿、武靴藤和虱草花放入容器中,首先加入10-15倍量蒸馏水浸泡4-5小时后,加热煮沸3-4小时,提取;第二次加8-10倍量蒸馏水加热煮沸2-3小时,提取;第三次加6-8倍量蒸馏水加热煮沸1-2小时,提取;合并提取液,滤过,得滤液备用;
(2)取球兰绞汁,滤杂质,留汁液,备用;
(3)将胜红蓟和蘘荷微波烘干,研末,过160目细粉,备用;
(4)取蜂胶浸入体积浓度为90%酒精溶液,静置4小时,取出上层清液,沉淀下来的浸膏备用;
(5)将步骤(1)-步骤(4)制得的滤液、汁液、细粉和浸膏混合,制成片剂,即为本发明所述的用于治疗外耳道炎的中药制剂。
用法用量:口服,每次2片,每日3次,7天为一疗程,轻者3到4个疗程即可痊愈,病情严重者遵医嘱酌增用量。
实施例2
本发明中药制剂有效成分的原料组成及重量为:
本实施例的中药制剂制备方法工艺步骤及用法用量与实施例1相同。
实施例3
本发明中药制剂有效成分的原料组成及重量数为:
本实施例的中药制剂制备方法工艺步骤及用法用量与实施例1相同。
实施例4
本发明中药制剂有效成分的原料组成及重量数为:
本实施例的中药制剂制备方法工艺步骤及用法用量与实施例1相同。
临床资料:
1、病例选择:
作为治疗外耳道炎的中药制剂,选择我院或外院确诊的外耳道炎患者120例临床观察,病人随机分成两组,治疗组60例,其中男性30例,女性30例,年龄18-65岁,平均年龄39岁,病程5个月-10年;对照组60例,其中男性30例,女性30例,年龄20-62岁,平均年龄42岁,病程5个月-8年。两组病例的病程、症状轻重程度基本一致,无显著差异,具有可比性。
2、药物选择:
治疗组患者服用本发明药物,成人每日3次,每次2片,饭后半小时内温开水送服,7天为一疗程,连续服用3到4个疗程即可痊愈,病情严重者遵医嘱酌增用量。
对照组服用阿莫西林,按说明书用,病情严重者遵医嘱酌增用量。
3、疗效判定:
(1)治愈:耳廓痛、外耳道疼痛、外耳道狭窄、血性耳漏、耳前淋巴结肿大、易哭、挖耳出血、耳流脓、耳痒、双耳廓缺损等外耳道炎症状痊愈。
(2)有效:上述症状有所缓解。
(3)无效:病症无变化。
4、结果:
服用本发明药物的治疗组中,治愈48例,有效8例,无效4例,治愈率为80%,总有效率93.3%。
对照组中治愈18例,有效20例,无效22例,治愈率为30%,总有效率63.3%。
以上结果显示,治疗组治愈率和总有效率明显高于对照组。
典型病例举例:
1、代某,女,8岁,学生,河南平顶山人。患者同小伙伴互相嬉闹玩水,突感一股水直冲右耳,当时未在意,只是头朝下拍了拍耳朵。后用棉签掏耳朵,感右耳疼痛,遂来我院就诊,诊断为外耳道炎。给予服用本发明中药制剂,服用3个疗程后,疼痛消失,身体恢复正常,没有复发。
2、张某,女,20岁,学生,内蒙古赤峰人。患者2年前挖耳后感右耳内疼痛,遂来我院就诊,医师会诊诊断为外耳道炎。给予服用本发明中药制剂2个疗程,疼痛好转,继续服用本发明中药制剂2个疗程,疼痛消失,身体恢复正常,痊愈,至今未复发。
3、杜某,男,26岁,业务员,吉林白山人。患者出现右耳痛的症状,张口时疼痛加重,在多处医院治疗未见好转。后来我院治疗,经检查确诊为外耳道炎。服用本发明药物1个疗程后,身体状况好转,继续服用本发明中药制剂2个疗程,痊愈,未复发。
4、林某,男,32岁,外企员工,山东枣庄人。患者挖耳时,因用力过度出现出血的症状,未引起重视,后发现耳内有流脓伴疼痛的症状,遂来我院就诊,经检查确诊为耳道炎。给予服用本发明药物3个疗程后,上述症状完全消失,疼痛消失,痊愈,至今未复发。
5、韩某,男,40岁,门卫,江苏扬州人。患者因出现外耳道灼热、疼痛、发热等症状来我院就诊。经检查诊断为外耳道炎。给予服用本发明中药制剂1个疗程,疼痛好转,继续服用本发明中药制剂2个疗程,疼痛消失,身体恢复正常,痊愈,至今未复发。
6、杨某,女,26岁,会计,甘肃兰州人。患者因洗海澡时,被浪将海水打入耳内,造成感染,出现听力下降、耳痒等症状来我院进行检查,确诊为外耳道炎伴。给予服用本发明中药制剂1个疗程,上述症状好转,继续服用本发明中药制剂2个疗程,上述症状消失,身体恢复正常,痊愈,至今未复发。
Claims (5)
1.一种用于治疗外耳道炎的中药制剂,其特征在于:制成所述中药制剂有效成分的原料组成及重量份数为:
磨盘根68-90份苘麻65-85份斑鸠菊60-80份球兰50-74份
狗牙贝40-65份岩葱40-60份老龙皮40-60份黄菀35-55份
驱风通25-50份衰草25-40份胜红蓟25-40份角蒿20-35份
武靴藤18-35份蘘荷10-20份虱草花10-20份蜂胶5-15份。
2.根据权利要求1所述的一种用于治疗外耳道炎的中药制剂,其特征在于:制成所述中药制剂有效成分的原料组成及重量份数为:
磨盘根84份苘麻80份斑鸠菊75份球兰68份
狗牙贝59份岩葱55份老龙皮55份黄菀50份
驱风通44份衰草36份胜红蓟36份角蒿31份
武靴藤31份蘘荷17份虱草花17份蜂胶12份。
3.根据权利要求1所述的一种用于治疗外耳道炎的中药制剂,其特征在于:制成所述中药制剂有效成分的原料组成及重量份数为:
磨盘根79份苘麻75份斑鸠菊70份球兰62份
狗牙贝53份岩葱50份老龙皮50份黄菀45份
驱风通38份衰草32份胜红蓟32份角蒿27份
武靴藤27份蘘荷15份虱草花15份蜂胶10份。
4.根据权利要求1所述的一种用于治疗外耳道炎的中药制剂,其特征在于:制成所述中药制剂有效成分的原料组成及重量份数为:
磨盘根73份苘麻70份斑鸠菊65份球兰56份
狗牙贝47份岩葱45份老龙皮45份黄菀40份
驱风通32份衰草28份胜红蓟28份角蒿23份
武靴藤23份蘘荷12份虱草花12份蜂胶7份。
5.一种如权利要求1-4任一项所述的用于治疗外耳道炎的中药制剂的制备方法,其特征在于:包括以下工艺步骤:
(1)将磨盘根、苘麻、斑鸠菊、狗牙贝、岩葱、老龙皮、黄菀、驱风通、蓑草、角蒿、武靴藤和虱草花放入容器中,首先加入10-15倍量蒸馏水浸泡4-5小时后,加热煮沸3-4小时,提取;第二次加8-10倍量蒸馏水加热煮沸2-3小时,提取;第三次加6-8倍量蒸馏水加热煮沸1-2小时,提取;合并提取液,滤过,得滤液备用;
(2)取球兰绞汁,滤杂质,留汁液,备用;
(3)将胜红蓟和蘘荷微波烘干,研末,过160目细粉,备用;
(4)取蜂胶浸入体积浓度为90%酒精溶液,静置4小时,取出上层清液,沉淀下来的浸膏备用;
(5)将步骤(1)-步骤(4)制得的滤液、汁液、细粉和浸膏混合,制成片剂,即为所述的用于治疗外耳道炎的中药制剂。
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